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41721593 | Chemically Stable and Porous Cobalt-Based Prussian Blue Analogue Metal-Organic Framework Serving as a Competent Cathode for Aqueous Zinc-Ion Batteries. | Aqueous zinc ion batteries (AZIBs) are emerging as safe, low-cost, and high-capacity devices for sustainable energy storage. Herein, Cobalt-based Prussian Blue Analogues (PBAs: a subclass of porous metal-organic frameworks-MOFs) have been strategically synthesized with different secondary transition metal ions: mangane... |
41721544 | Redefining Separator Design and Water Activity for High-Energy Zinc Batteries Using Covalent Organic Framework. | Despite zinc metal batteries offering attractions such as natural abundance, safety, and sustainability, their widespread adoption is hindered by a critical, underexplored limitation: intrinsically low device-level energy density. While previous research has prioritized stabilizing zinc anodes to suppress dendrites, pr... |
41994102 | The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation. | Once known only for its deadly effects, venom is now valued for its medicinal potential. The transformation of venomous substances into therapeutic agents, focusing on the synergy between natural toxins and drugs, is a recent topic of interest to the scientific community worldwide. Venom is a concoction of various biom... |
41889757 | Heteroaggregation of Antimicrobial Peptides LL-37 and HNP‑1 Drives Cooperative Neutralization of Cytotoxicity. | Synergistic bactericidal effects between antimicrobial peptides (AMPs) have been widely studied, yet their cooperative roles in reducing host-cell cytotoxicity remain poorly understood. Inspired by the cross-seeding observed in α-synuclein and β-amyloid fibril formation, we report that the cooperative reduction of cyto... |
41889735 | Nitric Oxide Insertion into a Metalloporphyrin-Carbon Bond. | Nitric oxide (NO) insertion into a metalloporphyrin rhodium-carbon bond is observed when crystals of (TPP)-Rh-(C<sub>6</sub>H<sub>4</sub>Cl)-(CH<sub>2</sub>Cl<sub>2</sub>) <sub><i>x</i></sub> (TPP = tetraphenylporphyrinato dianion) are exposed to NO gas over a two week period. The NO-inserted product was identified by ... |
41853695 | Amphiphilic Macromolecular Dendritic Antioxidants with Surfaces Coated in Hybrid Phenolic Units That Provide Anti-Inflammatory Properties. | Excess free radicals cause oxidative stress, which damages cells and triggers inflammation. Inflammation generates more radicals, creating a self-perpetuating cycle that contributes to many human diseases. Antioxidants can neutralize radicals and prevent inflammation. Two unique amphiphilic dendritic antioxidants, Gene... |
41853166 | Elucidating the influence of secondary nitrogen precursors on the performance of Fe-N-C catalysts for proton exchange membrane fuel cells. | Proton exchange membrane fuel cells (PEMFCs) offer high efficiency, rapid refueling, and zero-carbon operation, but their commercialization is constrained by the cost of platinum-based oxygen reduction catalysts. Transition metal-nitrogen-carbon materials, particularly Fe-N-C, are promising platinum-free alternatives, ... |
41852629 | Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors. | The development of selective histone deacetylase inhibitors (HDACi) and thus the identification of suitable chemical probes is still highly complex. Moreover, in the past, the results of oversimplified biochemical HDAC assays have often been overinterpreted. This has led to the extensive use of various supposedly isofo... |
41846088 | Integrative analysis of CUT&Tag-seq and RNA-seq reveals widespread H3K27ac upregulation associated with the activation of muscle-growth-related transcriptional programs in broiler breast muscle. | Broilers have developed pronounced features of metabolizable energy intake and rapid growth during long-term selection, yet whether their epigenetic landscape has undergone systematic alterations remains unclear. In this study, using transcriptome and H3K27ac CUT&Tag data from White-feathered broilers and Wenchang chic... |
41835575 | Regulation of Dormancy-Associated Genes <i>dosR</i> by TetR Family Regulator MRA_0776 in <i>Mycobacterium Tuberculosis</i> H37Ra. | <h4>Background</h4>The Dormancy survival regulator (DosR), Rv3133c, is one of the key transcriptional proteins that regulate the dormancy of <i>Mycobacterium tuberculosis</i> (MTB), participates in various metabolic processes, and is essential for the survival of MTB in the host. MRA_0776 (homologous with Rv0767c and M... |
41835572 | Electrochemical Determination of Nitroguanidine among Other Explosives Using Polymerized 2‑Nitrophenol/Reduced Graphene Oxide-Modified Glassy Carbon Electrode. | In this study, a novel sensor working electrode was fabricated by functionalizing a glassy carbon (GC) electrode surface with electrochemically reduced graphene oxide (ERGO) and poly-2-nitrophenol (P2NP, electrochemically polymerized, used as a hydrogen-bonding substrate) using the proposed square-wave voltammetry (SWV... |
41835547 | In Silico Profiling of Phytochemicals for Modulating Amyloid Beta-Mediated Immune Regulation and Neuroinflammation in Alzheimer's Disease. | The etiology of Alzheimer's disease (AD) has been extensively studied for a long time, primarily associated with multifaceted mechanisms involving aggregation of amyloid beta, tau hyperphosphorylation, neuroinflammation, and immune regulation. Current therapeutics for AD are significantly targets to attenuate the cogni... |
41835546 | Electrospun 3D Nanofiber Scaffolds with Adhesion-Enhanced Interfaces for Cell Culture. | Creating three-dimensional (3D) fibrous scaffolds has long been a challenging task due to difficulties in controlling fiber assembly and maintaining structural stability. Polystyrene (PS), a synthetic polymer with self-assembling properties, enables the formation of porous 3D architectures via electrostatic fiber repul... |
41821967 | Sterically Stabilized Homoleptic Copper and Gold Allyl Complexes. | Well-defined allyl derivatives of the coinage metals remain rare, often owing to their thermal and redox sensitivity. We report the isolation of a potassium bis-(allyl)-cuprate, [KCuA'<sub>2</sub>] (A' = 1,3-(SiMe<sub>3</sub>)<sub>2</sub>C<sub>3</sub>H<sub>3</sub>), prepared with either solution or mechanochemical meth... |
41800408 | Diagnostic value and challenges in the immune regulation of pentraxin 3 in infectious diseases. | Infectious diseases pose a severe threat to human health, and their early and precise diagnosis and intervention remain a major challenge in clinical practice. This review systematically examines the diagnostic value and immunomodulatory role of PTX3 across a spectrum of infectious diseases, including those affecting t... |
41799880 | Ferroptosis in Parkinson's disease: a review of molecular mechanisms and emerging therapeutic strategies. | Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra and the presence of Lewy bodies containing aggregated <i>α</i>-synuclein (α-syn). While these pathological hallmarks are well-established, the mechanisms underlying neurona... |
41799446 | Advancing universal health coverage through non-medical interventions: the evolution and equity of China's National Fitness policy system. | <h4>Background</h4>Physical inactivity is a primary driver of non-communicable diseases (NCDs), posing a significant threat to the fiscal and operational sustainability of Universal Health Coverage (UHC). In China, the National Fitness initiative serves as a critical preventive health framework within the "Healthy Chin... |
41799273 | Advances and applications in medical coating materials: a comprehensive review. | This review synthesizes the current state of knowledge on medical-coating materials. Fundamental theories are examined with respect to material taxonomy, physicochemical properties, biocompatibility profiles, and antimicrobial mechanisms. Clinical applications are reviewed for implants, wound dressings, catheters, and ... |
41798932 | Ocular social jetlag: a driver of immune-metabolic dysfunction in dry eye disease. | Dry eye disease (DED) is increasingly prevalent among young individuals and often exhibits severe symptoms despite minimal structural damage, challenging the traditional structure-inflammation paradigm. We propose the concept of ocular "social jetlag," defined as chronic circadian misalignment imposed by modern lifesty... |
41798758 | A neuregulin-like ligand and EGF receptor underpin <i>Echinococcus multilocularis</i> development. | Alveolar echinococcosis (AE), a neglected zoonotic disease, is caused by the infiltrative growth of the metacestode larval stage of the cestode <i>Echinococcus multilocularis</i> within host organs. We previously showed that metacestode development relies on the mitotic activity of a population of parasite stem cells k... |
41797801 | Integrating network pharmacology, molecular docking and dynamics simulation to decipher the antipyretic mechanisms of Xiaochaihu granules. | <h4>Background</h4>Xiao-Chai-Hu granules (XCHG), a classical traditional Chinese medicine formula derived from the ancient text Erta Treatise on Febrile Diseases, has demonstrated established clinical efficacy in fever management; however, the underlying antipyretic mechanism remains incompletely understood.<h4>Methods... |
41797784 | Contemporary management of treatment-related dermatologic toxicities in gynecologic cancers: a systematic review based on evidence from 2021 to 2025. | <h4>Introduction</h4>Gynecologic cancers are commonly managed with chemotherapy, radiotherapy, and targeted therapies, which are effective but frequently associated with significant skin side effects. These dermatologic toxicities substantially reduce patients' quality of life and treatment adherence, highlighting the ... |
41796500 | Hydrothermal-responsive plasmonic aerogel for dynamic 3D hotspot regulation and ultrasensitive SERS detection of dairy products contaminants. | <h4>Background</h4>Ensuring the safety of dairy products requires rapid, sensitive, and cost-effective detection of chemical contaminants.<h4>Results</h4>We developed a green and versatile plasmonic aerogel SERS substrate via covalent cross-linking of κ-carrageenan and dialdehyde cellulose (DAC), decorated with in situ... |
41782995 | Nanomedicine based on collagenase penetration for tumor immunotherapy induced by low-dose chemotherapy. | Despite extensive research on functional nanomaterials for antitumor applications, their efficacy remains limited by the complex tumor microenvironment (TME). Dense extracellular matrix (ECM) and aberrant vasculature impede nanoparticle penetration into solid tumors, reducing treatment efficacy in deep-seated regions. ... |
41782993 | Revolutionizing protein degradation: Harnessing nanoparticles for PROTAC delivery. | Proteolysis-targeting chimera (PROTAC) represents a paradigm shift in drug discovery, offering a promising therapeutic strategy for cancers, neurodegenerative diseases, and hematological malignancies. Unlike traditional small-molecule inhibitors that require occupancy of an active site, PROTAC operates via an event-dri... |
41769067 | Nutritional, Anti-inflammatory, and <i>in-silico</i> inhibitory Studies of <i>Trametes versicolor</i> (L.) Lloyd and <i>Flammulina velutipes</i> (Curtis) on HER2 breast cancer protein. | This study evaluated the phytochemical, nutritional, anti-inflammatory, and <i>in-silico</i> anticancer properties of <i>T. versicolor</i> and <i>F. velutipes</i>. Phytochemical screening revealed high levels of phenols, saponins, and flavonoids in both species. Nutritional profiling showed <i>F.velutipes</i> had highe... |
41767800 | Zero-trigger ultrafast charge-transfer J-aggregates <i>via</i> Se/π-directed assembly enable synchronous ROS/heat amplification for NIR-II photoimmunotherapy. | Supramolecular J-aggregation of π-conjugated photosensitizers provides a powerful strategy to optimize phototheranostic performance. However, integrating facile assembly with photodynamic and photothermal (PDT/PTT) synergy remains challenging. Herein, we report a charge transfer (CT)-state J-aggregation paradigm using ... |
41762563 | Differentiation of positional isomers of branched-chain fatty acids using ion mobility-mass spectrometry based on host-guest chemistry. | This study presents a rapid, non-derivatization method using ion mobility-mass spectrometry (IM-MS) to differentiate short-chain branched-chain fatty acid (BCFA) positional isomers in food products. The core strategy involves selectively forming host-guest complexes between the target isomers and crown ethers (B12C4 or... |
41757336 | Surface-Engineered Precision Nano-Systems for Targeted Treatment of Huntington's Disease: A Review of Recent Advancements. | Huntington's disease is a progressive neurological disorder marked by motor, cognitive, and psychiatric symptoms. Currently, there are no definitive diagnostic tools or effective treatments to halt or reverse the disease. In recent years, surface-engineered nanosystems have emerged as innovative therapeutic platforms, ... |
41753922 | MXene- and MOF-Based Hydrogels: Emerging Platforms for Electrochemical Biosensing and Health Monitoring. | Smart healthcare is rapidly emerging as a transformative paradigm, enabling simultaneous health monitoring, therapeutic intervention, and early prediction of disease onset. In this context, electrochemical monitoring systems have attracted growing interest due to their cost-effectiveness, ease of operation, miniaturiza... |
41752150 | Structure-Reactivity Relationships in <i>N</i>-Methylpyridinium Aldoxime Isomers: Comparative Experimental and Computational Studies. | The relative position of the oxime group within pharmaceutically relevant pyridinium oximes is a pivotal factor that governs their intrinsic physicochemical properties and their biological reactivity. However, studies providing in-depth, molecular-level insight into these structure-reactivity relationships are still li... |
41752139 | Epigenetic-Genetic Coupling and Understanding the Molecular and Cellular Basis of Lamarckian Inheritance. | This critical and selective review synthesizes the accumulating body of biological evidence supporting a process we term <i>epigenetic-genetic coupling</i> as a mechanistic basis for Lamarckian inheritance of somatically acquired adaptations. We propose that evolutionary processes in mammals and higher vertebrates can ... |
41750964 | Exploring the Impact of Lipid Structure and Composition on the Digestion of Next-Generation Meat and Dairy Analogues. | The world population is increasing exponentially and is expected to reach 9.2 billion people by 2040, intensifying pressures on food systems and raising concerns regarding food security and environmental sustainability. In response, plant-based and microbially sourced meat and dairy analogues have emerged as alternativ... |
41750396 | Modulation of α-Synuclein Oligomer and Aggregate Populations by pH and Metal Ions. | α-Synuclein (α-syn) aggregation underlies synucleinopathies, yet the physicochemical determinants that govern which assembly states form under defined solution conditions remain incompletely resolved. Here, we examine how pH and metal ions reshape α-syn self-assembly. Across acidic and physiological pH conditions, α-sy... |
41747453 | Advanced forensic detection of gunshot residues using luminescent lanthanide metal-organic framework. | The global rise in firearms-related crimes underscores the urgent need for rapid, sensitive, and field-deployable analytical tools to detect gunshot residues (GSR). Unlike earlier studies that utilized Lanthanide Metal-Organic Frameworks (Ln-MOFs) primarily as optical taggants incorporated in non-toxic ammunition, this... |
41747340 | Albumin-hitchhiking self-assembly full-API nanoparticles for imaging-guided photodynamic potentiating tumor immunotherapy. | Disrupting intracellular redox homeostasis may modulate the release of molecular patterns associated with tumor damage, contributing to promoting immunogenic cell death (ICD) for immunotherapy. However, tumors typically exhibit an immunosuppressive microenvironment, which can impede the activation of ICD, thereby enabl... |
41745776 | Discovery of Two Novel Scorpion Venom Peptides Activating TRPML2 to Impair ZIKV Internalization. | The endo-lysosomal channel TRPML2 regulates key processes like membrane trafficking and autophagy, which are hijacked by many RNA viruses during endocytic entry. However, the development of TRPML2-targeted therapeutics has been hindered by a notable lack of high-affinity and selective peptide-based activators. Scorpion... |
41745188 | Development of Biological-Window-Active Au Open-Shell Nanoparticles with High-Sensitivity Surface-Enhanced Raman Scattering Imaging Probe Properties. | The development of anisotropic gold nanostructures supporting localized surface plasmon (LSP) resonances in the near-infrared (NIR) biological window is of great interest for diagnostic and therapeutic nanotechnologies. Here, we report gold open-shell nanoparticles (AuOSNs), a symmetry-broken nanoshell architecture exh... |
41745051 | Hydrogel-Based Therapeutic Strategies for Post-Cholecystectomy NAFLD: Targeting Bile Acid Signaling, Gut Microbiota, Inflammation, and Hepatic Fibrosis. | Post-cholecystectomy non-alcoholic fatty liver disease (NAFLD), now encompassed within metabolic dysfunction-associated steatotic liver disease (MASLD), is increasingly linked to persistent disruption of bile acid kinetics and gut-liver axis signaling after gallbladder removal. Continuous bile delivery to the intestine... |
41737001 | Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets. | Polydopamine (PDA) is widely used to functionalize materials and enhance cell attachment. At the same time, the potential of the dopamine precursor tyrosine in its polymerized form (polytyrosine, PTYR) remains underexplored despite its biological activity. In this study, we developed nanostructured PDA and PTYR layers ... |
41734424 | Bioactive fusion: The evolution of metal-organic framework/keratin composites in unveiling the biomedical applications. | Metal-organic frameworks (MOFs), with their high porosity, tunable architectures, and multifunctionality, have become a major area of research in the biomedical sciences. Keratin, a natural biopolymer rich in sulfur-containing amino acids, exhibits mechanical stability, intrinsic bioactivity, and excellent biocompatibi... |
41728078 | Synthesis and characterization of ZrFe<sub>2</sub>O<sub>4</sub> and ZrFe<sub>2</sub>O<sub>4</sub>@UiO-66-NH<sub>2</sub> nanoparticles for efficient immobilization of <i>Humicola insolens</i> lipase: a comparative study of precipitation-crosslinking... | This study focused on immobilizing <i>Humicola insolens</i> lipase onto magnetic nanoparticles of ZrFe<sub>2</sub>O<sub>4</sub> and ZrFe<sub>2</sub>O<sub>4</sub>@UiO-66-NH<sub>2</sub> using precipitation-crosslinking and covalent binding methods. Characterization techniques, including FT-IR, SEM, energy-dispersive X-ra... |
41728039 | Nanoremediation of arsenic from contaminated water by new generation graphene-based nanomaterials: a comprehensive review. | Water contamination by metals and metalloids, particularly arsenic (As), is a serious global issue and a pressing challenge for countries with limited water resources. Since As is derived both from natural sources and human activities, including industrial effluents, agricultural runoff, and domestic sewage water disch... |
41727722 | Flipper dendrimers. | Fluorescent flippers have been introduced as small-molecule probes to image physical forces within cell membranes. Despite their popularity and much effort, significant improvements of performance have not been reported since their first design. Now, almost a decade after their introduction, we disclose flipper dendrim... |
41726245 | Imidazolium <i>versus</i> phenylalaninium hybrid salts: supramolecular control of electronic, nonlinear optical and bioactive properties. | Two new amino-acid-based hybrid salts, l-phenylalaninium chloride (1) and l-histidinium iodide (2), were synthesized and comprehensively characterized to elucidate how cation identity, halide nature, and supramolecular architecture govern their optical, electronic, and biological properties. Single-crystal X-ray diffra... |
41726224 | Multiscale modeling of graphene and carbon nanostructures: advances in atomistic, coarse-grained, and machine learning approaches. | Graphene, its derivatives such as graphene oxide and reduced graphene oxide, and related carbon nanostructures including carbon nanotubes, possess exceptional mechanical, thermal, and electronic properties. These features make them highly attractive for applications ranging from energy storage and filtration to flexibl... |
41725827 | A novel flexible egtazic acid/cerium-based metal organic framework as a potent catalyst for the synthesis of benzochromenoquinolinones and triazolopyrimidines. | The sponge-like structures of metal-organic frameworks (MOFs) are ideal platforms for various applications due to their structural diversity and adjustability, which allow for targeted design and synthesis. In recent years, substantial advances in the field of MOFs have been achieved, especially those containing aromat... |
41724158 | Dual-signal cross-validation via ECL quenching and DPV oxidation on a MIP sensor: ultrasensitive detection of sulfadiazine in complex food matrices with a CD-COF core. | The excessive use of sulfadiazine (SDZ) poses significant health risks due to toxic residues in food and ecosystems. This work introduces a novel molecularly imprinted polymer (MIP) sensor featuring a carbon dot-based covalent organic framework (CD-COF) core as a high-performance electrochemiluminescence (ECL) emitter.... |
41723989 | "Self" signal-suppressed metal-organic framework (MOF) nanodrug for enhanced immunotherapy of melanoma via CD47 blockade. | Melanoma is a highly aggressive form of skin cancer with poor prognosis. CD47, a well-known "don't eat me" signal, plays an important role in tumor immune evasion. In addition to immune checkpoint blockade, the STING-related pathway has emerged as a critical mechanism in activating innate immunity against tumors. Impor... |
41721403 | From biomolecular condensates to functional nanomaterials: LLPS-inspired frameworks for nanoscale hydrogels and adaptive materials. | Liquid-liquid phase separation (LLPS) has emerged as a fundamental mechanism for intracellular organization and dynamic regulation, while nanoscience provides precise tools for designing matter at the nanoscale. LLPS-driven condensates behave as dynamic, nanoscale hydrogel-like networks, offering a unifying physical fr... |
41721316 | Endothelial microparticles in high glucose environment: molecular pathways of GDM-associated placental dysfunction and coenzyme Q10-based targeted therapy. | Gestational diabetes mellitus (GDM) is frequently linked to placental overgrowth and hypertrophy, while maternal hyperglycaemic environment consistently induces systemic vascular endothelial cell injury. Damaged endothelial cells stimulate the release of endothelial microparticles (EMPs), but their impact on placental ... |
41721076 | A self-healing hydrogel based on modified chitosan and sodium alginate oxide reinforced with hydrophilic nanomaterials for wound dressing applications. | N-carboxyethyl chitosan (CECS) and sodium alginate oxide (SAO) are two biomaterials extensively used in tissue engineering, particularly in wound dressing (WD) applications. Nonetheless, these materials exhibit certain limitations such as inadequate physicomechanical properties, limited antibacterial activity in non-ac... |
41720819 | Variants in MTNAP1 underlie a neurodegenerative disorder by impairing mitochondrial stability. | Mutations in genes encoding mitochondrial proteins are increasingly recognized as a major cause of neurodegenerative disorders, owing to the role of mitochondria in neuronal energy metabolism and signaling. Here, we investigate MTNAP1 (mitochondrial nucleoid-associated protein 1) as a novel gene associated with an auto... |
41720818 | A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses. | The recurrent emergence of ACE2‑using sarbecovirus underscores the need for a broadly protective vaccine. Here, we mapped the antigenic landscape of sarbecovirus receptor-binding domains (RBDs) and identified three distinct clusters. We then engineered a single "three‑in‑one" immunogen, 3Rs-NC, incorporating representa... |
41720791 | Genomic and phenotypic insights into quorum sensing-mediated spoilage of Morganella psychrotolerans isolated from tuna. | Microbial metabolism plays a significant role in seafood spoilage, with quorum sensing (QS) systems potentially influencing bacterial spoilage abilities. In this study, we conducted genome sequencing of Morganella psychrotolerans GWT 901, which was isolated from spoiled yellowfin tuna. Genes related to QS and spoilage,... |
41720782 | Precision engineering chiral interfaces for efficient spin injection in metal halide heterostructures. | Precise control of interfaces is crucial for spin generation, transport, and detection in opto-spintronics. However, the interface engineering for efficient spin injection remains a significant challenge. Here, we synthesized a helical structure of PbI<sub>2</sub> (R-PbI<sub>2</sub>) via an interfacial chirality-induce... |
41720772 | In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism. | The post-genome packaging mechanisms that govern the assembly of an infectious virion are poorly understood in bacteriophages and other viruses. Here, our near-atomic resolution cryo-EM structural analyses uncovered an assembly- and conformation-driven genome positioning mechanism in the tailed bacteriophage T4. We sho... |
41720747 | Rational Design of a "Turn-on" Supramolecular Fluorescent Probe for Gossypol Sensing Based on the Restriction of Intramolecular Bending Mechanism. | The development of ″turn-on″ supramolecular fluorescent probes for detecting biologically important molecules lacking reactive sites, with a clear mechanistic understanding, remains challenging. To address this challenge, this study establishes and validates a rational design strategy based on the restriction of intram... |
41720474 | TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding. | Double-stranded RNA (dsRNA) has become an essential tool to understand biological processes with promising therapeutic implications. However, its usage is often limited due to poor cellular uptake and instability in biological settings. Peptidic dsRNA binders, inspired by natural RNA-binding proteins, have emerged as p... |
41719529 | Effect of counteranions on the crystal structures of Zn<sup>II</sup> coordination polymers with 1,3-bis(1H-imidazol-1-yl)benzene. | Two new coordination compounds, catena-poly[[[diaquazinc(II)]-bis[μ-1,3-bis(1H-imidazol-1-yl)benzene]] bis(tetrafluoroborate)], {[Zn(C<sub>12</sub>H<sub>10</sub>N<sub>4</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](BF<sub>4</sub>)<sub>2</sub>}<sub>n</sub>, 1, and catena-poly[[[diaquazinc(II)]-bis[μ-1,3-bis(1H-imidazo... |
41719436 | A Nanofluidic Biosensing Spiking Synapse Enabled by Enzyme-Incorporated Metal-Organic Framework under Nanoconfinement. | Nanofluidic neuromimetic devices represent a promising technique for realizing the brain-inspired functions, yet one immediate problem that needs to be addressed to further its capability is the incorporation of biochemical specificity. Here, we report a nanofluidic biosensing spiking synapse based on the nanoconfineme... |
41719430 | TIP-20, a novel feline McDonough sarcoma-like tyrosine kinase 3 inhibitor with potent antileukemia activity. | PurposesMutations in the feline McDonough sarcoma-like tyrosine kinase 3 (FLT3) gene represent one of the most common genetic alterations in acute myeloid leukemia and are associated with an increased risk of relapse and poor prognosis. FLT3 inhibitors have significantly improved clinical outcomes in acute myeloid leuk... |
41719410 | CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter. | Many bacteria harbor an ATP-binding cassette (ABC) transporter named EgtU specific for the human dietary antioxidant and 2-thioimidazole-containing low-molecular weight thiol ergothioneine (ET). How the solute binding domain, EgtUC, discriminates among ET and other similar molecules is unknown. Here, we use a "chimeric... |
41719401 | Precise modulation of MOF pore structures via functional group dimensions and spatial configuration for membrane separation. | Traditional petroleum distillation faces high energy demands, necessitating innovative alternatives like membrane separation. This study presents a breakthrough in dual-range and precise pore size modulation of metal-organic frameworks (MOFs) through a ligand functionalization strategy. By tailoring steric configuratio... |
41719402 | Engineering controlled-release steroid therapeutics: fabrication and molecular design of self-assembled microparticles. | Steroids, specifically bile salts and corticosteroids, treat bile synthesis disorders, liver dysfunction, and inflammation. However, these water-soluble steroid drugs are rapidly cleared from the desired sites of action in the body, necessitating multiple doses. Therefore, the development of particle-based steroid medi... |
41719393 | Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy. | Urinary small extracellular vesicles (sEVs), which can reflect systemic conditions, hold great promise for noninvasive cancer diagnostics, yet the mechanism by which tumor-derived sEVs reach urine remains unclear. Here, we demonstrate that the glomerulus actively transcytoses circulating tumor-derived sEVs into urine. ... |
41719391 | 12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46<sup>+</sup> ILC3 development. | How intestinal immunity develops during early life remains a key question in understanding defense against infections. Group 3 innate lymphoid cells (ILC3s) are critical for this defense, and their developmental progression and subset balance are essential for effective immune function. Here, we show that the nuclear r... |
41719388 | Evolving synchronization of the Gulf Stream and Kuroshio-Oyashio Extension in a changing climate. | Decadal synchronization between the Gulf Stream and Kuroshio currents has recently been reported. Given the large-scale coupled variability of western boundary currents and extensions (WBCEs), further investigation into its seasonality, predictability, and potential future changes is needed. Observations and high-resol... |
41719344 | Identification of two terpenoids from Withania coagulans with predicted multitarget binding affinity: An in vitro and in silico study. | Withania coagulans (Dunal) Stocks, a medicinal plant of the Solanaceae family, has long been recognized in traditional medicine for its antidiabetic, antimicrobial, and antioxidant activities. In the present study, gas chromatography-mass spectrometry (GC-MS) analysis of the aqueous stem extract of W. coagulans reveale... |
41719342 | Remdesivir-bisPropionate, a better derivative of remdesivir against SARS-CoV-2: Comparison of in vitro and in vivo PK/PD Study as well as its therapeutic potential. | FDA approved remdesivir, which was though very effective against SARS-corona virus in cell culture system but in human its efficacy was below 10%, as reported. The main reasons are due to the poor stability of remdesivir in presence plasma. In order to increase the protective strength of remdesivir we took couple of ap... |
41719286 | Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications. | CMV/HIV coinfection markedly exacerbates disease progression, elevates treatment failure risk, and worsens patient outcomes, yet the underlying molecular mechanisms remain incompletely understood-creating an urgent need for targeted host-focused research. This study identifies asparagine synthetase (ASNS) as a pivotal ... |
41719001 | Binding interactions of Trametes villosa and Trametes lactinea laccases with 4-nonylphenol and its intermediates: molecular docking and molecular dynamics approaches. | Emerging pollutants such as 4-nonylphenol (4-NP) act as endocrine disruptors and have been associated with reproductive toxicity in humans and wildlife, as well as with physiological disturbances in aquatic, terrestrial, and plant organisms. Laccases are oxidoreductases with notable biotechnological relevance and the a... |
41718907 | M1 macrophage membrane-engineered PLGA nanoparticles reprogram M2 tumor-associated macrophages to enhance anti-tumor immunity in breast cancer. | Nanoparticles (NPs) are used as a suitable delivery system in cancer immunotherapy. Coating NPs with cell membranes can improve their therapeutic efficacy. Tumor-associated macrophages (TAMs) with a dominant phenotype of M2 and anti-inflammatory properties are found within the tumor microenvironment and contribute to t... |
41718797 | Emergence of satellite DNAs suggests centromeric repositioning as a driver of karyotypic variation of the freshwater darter characines (Apareiodon affinis). | Repetitive DNA sequences actively contribute to karyotype diversification by accumulating mutations, exhibiting susceptibility to DNA double-strand breaks that promote chromosomal rearrangements, and reshuffling within centromeric heterochromatin, among other processes. Parodontidae shows a conserved diploid number of ... |
41718758 | Aloe emodin disrupts Candida albicans mitochondrial iron homeostasis against its hyphal development and oral candidiasis. | Candida albicans, a critical pathogen listed on the WHO fungal priority pathogens list, is a major cause of candidiasis and candidemia, particularly in immunocompromised populations. The lack of novel antifungal drugs and the increasing prevalence of drug resistance underscore the urgent need for new therapeutic strate... |
41718751 | A CQDs-doped europium-DPA framework for fluorescence and colorimetric dual-mode sensing of amoxicillin and ciprofloxacin. | Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats ... |
41718691 | Multi-Metallic Organic Framework-Based Composites as Electrocatalysts. | Metal-organic frameworks (MOFs) demonstrate that they can be effective materials as electrocatalysts due to their high specific surface area and high metal content. However, aggregation and poor electrical conductivity can sometimes still affect MOF electrocatalytic activity. Consequently, electrocatalytic activity was... |
41718690 | Progress and Perspectives in Poly(meth) Acrylate/Acrylamide Derived Biosensing Technologies. | Poly(meth)acrylate and vinyl-based polymers have emerged as highly versatile functional materials for next-generation sensing technologies. Their tunable architectures, chemical stability, and ability to incorporate stimuli-responsive, fluorescent, or bioactive moieties enable precise detection in biomedical, environme... |
41718688 | Macrophage Phenotype-Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles. | The phenotype of source cells used for membrane coating fundamentally influences the biointerfacing behavior of cell membrane-coated nanoparticles. Meanwhile, the formation of a protein corona (PC) in biological fluids plays a pivotal role in dictating the in vivo fate of nanoparticles. Yet, how macrophage phenotypes i... |
41718677 | Direct Write, Read, and Erase of a Vertical Heterostructure of Graphene-Monolayer Electrolyte-h-BN Using Electric Force Microscopy. | Electric double layer (EDL) gating effectively modulates charge density in two dimensional (2D) crystals; however, the electrolyte is typically deposited on top of the 2D crystal, controlling charge most strongly in the 2D material it contacts directly. Here, a monolayer-thick electrolyte is positioned between two, 2D ... |
41718670 | Asymmetric Acidic-Alkaline Fuel Cell: Self-Powered Hydrogen Production and Advanced Oxidation of Sulfion and Hydrazine. | Current technologies of water electrolysis for hydrogen production and purification of industrial wastes are effective for mitigating environmental pollution. However, they are energy-intensive and cause indirect/direct CO<sub>2</sub> emissions. Here, we report the asymmetric acid-alkaline hydrazine-water fuel cell (Hz... |
41718658 | Construction of Octadentate Carboxylate-Based Metal-Organic Framework for Effective Acetylene Purification. | The development of high-performance acetylene (C<sub>2</sub>H<sub>2</sub>) adsorbents remains challenging, primarily due to the mutual repulsion between their adsorption capacity and selectivity. To address this challenge, we propose introducing multiple host-guest interaction sites into an octadentate carboxylate-base... |
41718560 | Substrate-Driven Coenzyme Activating Oxidase-Like Activity of Copper-Based Nanozymes for Robust Profiling of Sulfonamides. | Nanozymes offer significant advantages, including high stability, straightforward synthesis, and low cost, positioning them as viable alternatives to natural enzymes. However, the limited variety and specificity of nanozymes have been a persistent challenge. In this study, we developed a copper metal-organic framework ... |
41718544 | Amplifying Circularly Polarized Light Emission and Detection via Nonerosive Hetero-Ligand Complexation Doping in Cu(I)/Ag(I)-Cluster Microcrystal Scintillators. | Nonerosive lattice doping of chiral self-assembly is advantageous for applications in polarized optoelectronics, as it evades the packing of molecular rearrangements that preserve the optical activity of microcrystals. However, present chiral microcrystals of phosphine-involved clusters often suffer from low quantum yi... |
41718490 | A lipid nanoparticle-based mRNA vaccine elicits immunity against porcine circovirus type 2 in mice. | Porcine circovirus type 2 (PCV2), the primary etiological agent of porcine circovirus-associated diseases (PCVADs), continues to cause substantial economic losses worldwide. Although commercially available vaccines have been widely deployed, they often fail to induce sufficient cellular immunity, which necessitates the... |
41718477 | Multimodal Nanoscale Mapping of Local Structure and CO<sub>2</sub> Adsorption in Metal-Organic Frameworks. | Diamine functionalization of the metal-organic framework Mg<sub>2</sub>(dobpdc) (dobpdc<sup>4-</sup> = 4,4'-dioxidobiphenyl-3,3'-dicarboxylate) significantly enhances its selectivity for CO<sub>2</sub> capture from flue gases and air. The structure and CO<sub>2</sub> capacity of such materials are typically assessed us... |
41718458 | Rapid Discrimination of Single-Virus Entry Pathways via a Bioorthogonal Activatable Fluorescent Probe. | Viral transmembrane entry is a critical yet heterogeneous process that governs infectivity and pathogenesis. However, directly distinguishing virus attachment from internalization and resolving distinct entry mechanisms in real time at the single-virus level remains challenging. Here, we introduce a Bioorthogonal Click... |
41718454 | Emerging Trends in Phytochemical Nanomedicines for Lung Inflammation and Fibrosis Management. | Lung inflammation, injury, and fibrosis are interconnected facets of respiratory health. Damage to the inherent lung architecture and tissue scarring resulting from excessive extracellular matrix deposition are the most important characteristics of lung injury and fibrosis. Although the current treatment strategy like ... |
41717988 | Electrospinning Construction of a Porous Co/CoP/N-Doped Carbon Fiber Composite as a Bifunctional Electrocatalyst for Water Electrolysis. | Herein, a bifunctional composite electrocatalyst consisting of cobalt, cobalt phosphide, and nitrogen-doped carbon nanofibers (Co/CoP/N-CNFs) was fabricated for alkaline water splitting, enabling efficient hydrogen and oxygen evolution reactions. The material was prepared via electrospinning of polyacrylonitrile fibers... |
41717981 | High-Pressure Fabrication of Atomically Precise Chiral Silver Nanoclusters with High Luminescence Efficiency. | High-pressure reversibility is a predominant challenge restricting the practical application of hydrostatic pressure in high-pressure synthesis. Herein, we have successfully preserved the high-pressure metastable phase of an atomically precise chiral silver nanocluster {[<b>Ag</b><sub><b>8</b></sub>H(<i>D</i>/<i>L</i>-... |
41717971 | A Glutamine-Metabolism-Intervening Nanoplatform Activates Lipophagy to Potentiate Ferroptosis and Immune Activation in Breast Cancer. | Aberrant glutamine (Gln) metabolism in tumor cells contributes to ferroptosis resistance and immunosuppression, challenging ferroptotic therapy. Our preliminary bioinformatic data uncovered that elevated expression of SLC1A5, a critical Gln transporter, confers poor prognosis in breast cancer, underscoring its potentia... |
41717926 | Pharmacological and Genetic Targeting of Inflammatory Chemokine Receptors CCR1, CCR2, and CCR5 in Atherosclerosis: A Systematic Review and Meta-Analysis of Preclinical Studies. | <h4>Background</h4>Inflammatory chemokine receptors encompassing CCR1, CCR2, CCR3, and CCR5 orchestrate the recruitment of leukocytes during inflammation. In atherosclerosis, there is ongoing controversy surrounding the precise role each inflammatory chemokine receptor plays in the disease process. We thus performed a ... |
41717893 | From Covalent to Supramolecular: Re-Thinking Lysosome-Targeting Chimeras Through Modular and Tunable Proximity Control. | Proximity-based molecular strategies have reshaped chemical biology, yet their architectures remain dominated by covalent linkers that impose fixed stoichiometry and static control. Such rigidity limits adaptability, particularly in lysosome-targeting systems that operate within highly dynamic trafficking environments.... |
41716033 | Self-Assembly of a Therapeutic Peptide Surfactant: A Small-Angle X-ray Scattering Study. | Amphiphilic compounds are important in many fields including pharmaceutical processes and development. Synthetic surfactants are often toxic to biological systems and frequently display poor biodegradability. Biosurfactants, such as lipopeptides and bile salts, on the other hand, can offer superior properties with rega... |
41716020 | Beyond the membrane: Internalization and compartmentalization of insulin‑like growth factor 1 receptor signaling in cancer pathogenesis and treatment (Review). | The insulin‑like growth factor 1 receptor (IGF‑1R) plays a central role in tumor initiation, progression and response to treatment. IGF‑1R internalization and compartmentalization have profound effects on tumor biology, extending beyond classical signaling associated with receptors at the cell membrane. Following inter... |
41971692 | Recent Advances on Starch-Based Biomaterials: A Review. | Starch's versatility inspires biomaterials for biomedical uses, customized through modifications, blending, or substituents. Diligent efforts have been dedicated to the development of starch-based biomaterials, leveraging the material's inherent biocompatibility and biodegradability, while aligning with environmentally... |
41873322 | The Eye Cannot See What the Brain Does Not Know: A Report of Two Cases of Morton's Neuroma. | It is rare for patients to present to the plastic surgery department with foot pain. If this occurs, there is a high probability that these are patients who would have visited numerous hospitals without finding a solution to their complaints and have not recovered despite receiving various treatments. In such cases, Mo... |
41869160 | Association Between Oral Function and Underweight in Dental Outpatients Under Regular Maintenance: A Cross-Sectional Study. | Objective This study aimed to evaluate the prevalence of oral hypofunction among dental maintenance outpatients aged over 50 years who had completed dental treatment at least three months before and to explore the relationship among oral hypofunction, age, and underweight. Background Recently, the relationship between ... |
41852888 | Polymeric anti-platelet carriers for the precision-targeting of age-related cardiovascular and cerebrovascular diseases. | The global aging population has increased the burden of cardiovascular and cerebrovascular diseases, which remain leading causes of morbidity and mortality worldwide. In their pathogenesis, platelets not only promote thrombus formation but also exert proinflammatory effects that cause extensive inflammatory responses, ... |
41813337 | A reducing substances response ratio fluorescence system based on MnO<sub>2</sub>/MOF for the determination and distinction of organophosphorus pesticides and reducing biological molecules. | The residues of organophosphorus pesticides (OPs) in the environment and crops, resulting from irrational use will cause irreversible damage to the human nervous system by hindering acetylcholinesterase (AChE) activities. This study developed a novel proportional fluorescence sensing system based on UiO-66-NH<sub>2</su... |
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