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41810146 | Oxidative Ring-Opening of Dimethylfuran in Zeolitic Imidazolate Frameworks through Computational Design. | Furans are versatile feedstocks for producing valuable chemicals and fuels, with 2,5-dimethylfuran (DMF) particularly standing out for its potential in oxidative ring-opening reactions, yielding enediones. The zeolitic imidazolate framework ZIF-8 has shown promise as a mediator to achieve high selectivity, although a p... |
41800464 | Rare-earth cerium-coordinated ICG nanoprobe for tumor hypoxia relief and intensified photodynamic therapy. | Photodynamic therapy (PDT) utilizing organic photosensitizers like indocyanine green (ICG) faces several intrinsic limitations. These challenges include a propensity to aggregate, insufficient stability, and low intersystem crossing (ISC) efficiency that yields inadequate reactive oxygen species (ROS). Furthermore, the... |
41800311 | VLP-based indirect ELISA enables reliable sero-diagnosis and epidemiological monitoring of duck circovirus. | <h4>Introduction</h4>Duck circovirus (DuCV) is an emerging immunosuppressive virus that causes growth retardation, feather loss, and increased susceptibility to secondary infections in ducks, leading to significant economic losses in the duck industry. However, existing serological assays for DuCV detection often lack ... |
41800177 | Metformin-loaded J-AuPPS for infected diabetic wound treatment. | <h4>Introduction</h4>Infected diabetic wounds pose a significant clinical challenge owing to the complex wound microenvironment. Various multifunctional synergistic therapeutic nanomaterials have been successfully developed to treat diabetic infected wounds.<h4>Objective</h4>A Janus Au-porphyrin polymersome heterostruc... |
41800035 | Research progress on resistance mechanisms to CAR-T cell therapy in diffuse large B-cell lymphoma. | Chimeric antigen receptor T-cell (CAR-T) therapy represents a revolutionary immunotherapy modality that has fundamentally transformed treatment paradigms for relapsed/refractory (r/r) hematological malignancies. For patients with r/r diffuse large B-cell lymphoma (DLBCL), CD19-targeted CAR-T cell therapy is currently a... |
41800033 | The non-classical immune checkpoint HLA-G: a regulatory master switch governing tolerance, evasion, and translational frontiers. | Human Leukocyte Antigen G (HLA-G), a non-classical MHC Class I molecule, plays a pivotal role in immune regulation, particularly in reproductive immunology. It functions as an immune checkpoint by interacting with inhibitory receptors such as LILRB1 (ILT2/CD85j) and LILRB2 (ILT4/CD85d) on both innate and adaptive immun... |
41799438 | Restoring <i>Ag1</i>, an ancient regeneration gene lost in amniotes, accelerates skin healing in mice. | Tissue and organ regeneration is a remarkable ability observed in many animal species, which has been significantly reduced or lost in several vertebrate lineages, partly due to the evolutionary loss of regeneration-associated genes. For example, many genes involved in limb and skin regeneration in anamniotes (fish and... |
41799383 | Historical texts as a potential resource for plant-based antiviral agents against SARS-CoV-2: the example of the Receptarium of Burkhard III von Hallwyl from 16th-century Switzerland. | <h4>Background</h4>In search for effective prophylactic and possibly curative therapeutics against SARS-CoV-2, an historical-ethnopharmacological approach was used to select plants described in the Receptarium of Burkhard III von Hallwyl (RBH), a recipe text from 16th century Switzerland. Ten plant species were selecte... |
41799274 | Boron-based fire retardancy for natural polymeric materials. | The shift from fossil resources to natural polymers as the building blocks of a global bioeconomy is hampered by the intrinsic flammability of these bio-derived materials. In this paper, the recent advances in boron-based fire retardancy of natural materials are reviewed, highlighting the transition from macro-scale sa... |
41799113 | Progress, Challenges, and Opportunities in Ionic Liquid-Modified Polymer Membranes for CO<sub>2</sub> Separation. | Driven by the critical challenge of mitigating anthropogenic CO<sub>2</sub> emissions, the field of carbon capture and utilization (CCU) has undergone rapid development. Among these, membrane-based CO<sub>2</sub> separation stands out for its energy efficiency and ease of industrial implementation. However, challenges ... |
41799104 | Effect of Storage Conditions on Efficacy of Poly(ethylenimine)-Alumina CO<sub>2</sub> Sorbents. | Solid amine sorbents are one of the primary components of DAC technologies that allow for the removal of ultradilute CO<sub>2</sub> from the atmosphere. A main drawback in the implementation of solid amine sorbents in industrial-scale DAC applications is their instability under certain operational or storage conditions... |
41799099 | Dimethyl Sulfoxide-Coordinated Lead Chloride Complex, Pb<sub>2</sub>Cl<sub>4</sub>·3DMSO. | The lead chloride complex with dimethyl sulfoxide (Pb<sub>2</sub>Cl<sub>4</sub>·3DMSO) (<b>I</b>) was synthesized. The salt crystallizes in the centrosymmetric orthorhombic space group <i>Pnma</i>. The unit cell parameters are <i>a</i> = 13.9845(9) Å, <i>b</i> = 17.4787(11) Å, <i>c</i> = 7.3382(5) Å, <i>Z</i> = 4, and ... |
41799078 | Amine Tris(phenolate) Ligands as a Versatile Scaffold for Early and Late Transition Metals: Synthesis and Application. | Amine tris-(phenolate) (usually abbreviated as tpa) ligands have drawn much interest as ligands for early transition metals, because they create stable complexes with broad catalytic applications in oxygen transfer reactions, polymerization, and other organic/organometallic fields of chemistry. Over the last 10 years, ... |
41799060 | Beyond MIDAS: An <i>In Silico</i> Study of a Putative Noncanonical C16 Binding Site in αvβ3 Integrin. | Integrins are essential transmembrane receptors that mediate bidirectional signaling between the extracellular matrix (ECM) and the cytoskeleton. Among them, αvβ3 and α5β1 are key regulators of angiogenesis, metastasis, and tumor progression. The laminin-1-derived C16 peptide (KAFDITYVRLKF) interacts with both integrin... |
41798990 | Microbiota management: a perspective for kidney transplant patients. | Chronic kidney disease (CKD) is recognized as one of the most significant public health issues globally, with approximately 40% of patients progressing to end-stage kidney disease (ESKD). Transplantation remains the most indicated option for many patients with ESKD; however, these individuals frequently experience hosp... |
41798938 | Case Report: Interleukin-23 blockade achieves sustained remission in Niemann-Pick type C-associated Crohn's disease refractory to anti-tumor necrosis factor therapy. | <h4>Background</h4>Niemann-Pick type C (NPC) is a lysosomal lipid trafficking disorder that is associated with defective autophagy and impaired bacterial clearance, potentially predisposing patients to Crohn's disease (CD)-like granulomatous enteritis. Tumor necrosis factor-alpha inhibitors are typically the first-line... |
41798753 | Overcoming multidrug resistance: antimicrobial peptides as a next-generation therapeutic strategy. | Amidst the escalating global threat of antibiotic resistance, there is an urgent need for novel antibacterial agents with distinct mechanisms of action to address the impending post-antibiotic era. Antimicrobial peptides (AMPs), membrane-active peptides characterized by rapid bactericidal effects, broad-spectrum activi... |
41797816 | Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics. | Neurological diseases are leading causes of death globally and disability-adjusted life years (DALYs) globally. Because of this, urgency in providing technologies and essential medicines to tackle this issue is currently recognized as key in reversing this trend. Global health strategies have recognized tissue engineer... |
41789180 | Alcohol-Decorated Lignins for Nanoparticle Formation through Reactive Fractionation in Ternary Deep Eutectic Solvent Systems. | This study explores the use of ternary deep eutectic solvent (DES) systems composed of choline chloride (ChCl), oxalic acid (OA), and ethylene glycol (EG) for the efficient fractionation of lignocellulosic biomass and isolation of lignins with diverse structural features and EG incorporation levels. Reactive fractionat... |
41756136 | Competitive LC-MS/MS assay to investigate protein metalation dynamics. | Knowledge gaps in the biospeciation of potential metallodrugs may lead to the generalized assumption of their promiscuous reactivity and inherent toxicity, neglecting their pharmaceutical potential. Herein, we developed a rapid and competitive LC-MS/MS assay to determine metalation dynamics of protein mixtures by metal... |
41754701 | Green Synthesis of Molecularly Imprinted Polymers: Advances Toward Sustainable Materials. | Molecularly imprinted polymers (MIPs) are synthetic materials with highly selective recognition properties and are widely studied for applications in separation, sensing, catalysis, and biomedical analysis. However, conventional MIP synthesis often relies on toxic solvents and reagents, causing environmental and sustai... |
41752493 | Advances in Active Materials of Enzymatic Electrochemical Sensors for Detecting Organophosphorus Pesticides. | Organophosphorus pesticides (OPs) have been widely employed to increase food production and alleviate the increasingly serious food crisis. However, excessive use of these pesticides has seriously affected human health and even caused death due to significant pesticide residues in food. Therefore, enzymatic electrochem... |
41752489 | Host-Guest Chemistry as a Supramolecular Engine for Iontronic Transduction in Nanochannels. | Since the first synthetic macrocyclic receptors were shown to bind ions selectively, supramolecular host-guest chemistry has enabled the translation of molecular recognition events into physical signals. Early coupling of such receptors to ion-sensitive field-effect transistors established a bridge between supramolecul... |
41752131 | Genome-Wide Characterisation of the AP2/ERF Family in <i>Salvia miltiorrhiza</i> Identifies Hormone-Responsive Candidates Associated with Phenolic Acid Accumulation. | APETALA2/ethylene-responsive factor (AP2/ERF) transcription factors integrate phytohormone signalling with developmental programmes and specialised metabolism, yet their family-wide features and potential contributions to phenolic-acid biosynthesis remain to be systematically clarified in <i>Salvia miltiorrhiza</i>. In... |
41752118 | Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review. | Amyotrophic Lateral Sclerosis (ALS) is a severe, progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons, affecting 0.5 to 2.6 per 100,000 people, with a median survival of 2 to 5 years. It is increasingly seen as a multisystem disorder, sharing essential clinicopathological fe... |
41752117 | Lipid Regulation of Mechanosensitive Ion Channels. | Mechanosensitive ion channels (MSCs) are fundamental transducers that convert mechanical forces into electrochemical signals, enabling cells to regulate processes such as Ca<sup>2+</sup> homeostasis, migration, proliferation, and adhesion. Located in both plasma and organellar membranes, MSCs, including Piezos, TRPs, K... |
41750958 | Modulating the Physicochemical Properties and Internal Structure of Maize Starches with Differing Amylose Contents via Non-Covalent Interaction with Tea Polyphenols. | Starch-polyphenol interactions play a critical role in regulating the structural organization and thermal behavior of starch-based systems. In this study, maize starches with different amylose contents were used to systematically investigate how tea polyphenol (TP) complexation influences starch structure and thermal s... |
41747497 | Carbonized MOF-coated carbon fibers for an online in-tube SPME-HPLC-DAD method to determine polycyclic aromatic hydrocarbons in water. | To improve the extraction performance of carbon fibers (CFs) to polycyclic aromatic hydrocarbons (PAHs), the carbonized MOF-coated CFs (CFs@C-MOF) were fabricated for online in-tube solid-phase microextraction (SPME). ZIF-8 was grown on CFs at room temperature and subsequently carbonized at 350°C under nitrogen atmosph... |
41743232 | Nanotechnology-Driven Precision Modulation of Transplant Immunity: From Mechanistic Insights to Clinical Tolerance. | Organ transplantation represents a definitive therapeutic modality for end-stage organ failure, yet it is plagued by formidable challenges encompassing allogeneic immune rejection and the inherent limitations of conventional immunosuppressive regimens. Nonspecific immunosuppression not only precipitates severe adverse ... |
41745511 | Sustainable Membrane Technologies for Enhancing Urban Climate Resilience. | Growing wastewater volumes and intensifying water scarcity are driving the need for affordable, sustainable solutions that enable safe urban water reuse and strengthen climate resilience. Policy frameworks such as SDG6 and EU water reuse requirements highlight that reclaimed water must meet strict environmental and pub... |
41745510 | Membrane Separation for Rare Earth Elements (A Review). | Rare earth elements (REEs) are increasingly critical for advanced technologies like high-tech electronic devices, electric vehicles, catalysts, and supercapacitors. However, separating and purifying the REEs is challenging due to their similar physicochemical properties, such as ionic sizes and oxidation states. Tradit... |
41737918 | Synthesis of tricyclic fused pyrrolidine nitroxides from 2-alkynylpyrrolidine-1-oxyls. | Rotational correlation time is a key parameter for organic radical contrast agents (ORCA) for magnetic resonance imaging (MRI). Design of polycyclic systems with incorporated nitroxide moieties in which rotation of the radical separately from the framework is impossible is one of the ways to improve properties of ORCA.... |
41737044 | Nano-Reagents in Acute Pancreatitis: Diagnostic, Therapeutic, and Theranostic Advances. | This narrative review synthesizes the latest advances in nano-diagnostic and therapeutic reagents for acute pancreatitis (AP), based on peer-reviewed experimental and preclinical studies published in recent years. AP endangers life through self-digestion of pancreatic tissue and a cascading systemic inflammatory reacti... |
41726246 | Imidazole-2-thiohydantoin conjugates for trace water detection in organic solvents and visual colour recognition for real-time monitoring. | Trace water is a detrimental impurity present in organic solvents that negatively impacts various organic reactions, necessitating the development of new sensitive and selective methods for its detection. In this study, we develop two novel donor-acceptor molecules, Im-2TH and Di-OMeIm-2TH, using a Knoevenagel condensa... |
41726241 | Design of Al-decorated C<sub>24</sub>N<sub>24</sub> fullerene for efficient adsorption and removal of methylene blue dye from water. | In this study, density functional theory (DFT) is used to explore aluminum-doped porphyrin-like porous fullerene (Al<sub>6</sub>@C<sub>24</sub>N<sub>24</sub>) as a potential adsorbent for scavenging aquatic carcinogenic methylene blue (MB) dye. The Al<sub>6</sub>@C<sub>24</sub>N<sub>24</sub> system demonstrates thermal... |
41726239 | Mechanistic profiling and optimized production of Altenusin, a fungal carboxy-biphenyl scaffold for tyrosinase inhibition. | Tyrosinase is a binuclear copper oxidase central to melanogenesis and food browning and is a major target for depigmenting and anti-browning agents. Here we evaluate Altenusin, a fungal carboxy-biphenyl polyketide, as a tyrosinase-inhibitor scaffold by combining structure-based screening, enhanced fermentation and mech... |
41726233 | High-affinity nitrogen-doped graphene quantum dots for selective <i>in vivo</i> and <i>ex vivo</i> detection of amyloid-β plaques in an Alzheimer's disease rat model. | Early and precise detection of the amyloid-β (Aβ) aggregates is a critical factor in understanding Alzheimer's disease (AD) pathology. Current fluorescent probes for detecting Aβ plaques suffer from poor photostability, low selectivity, and ineffective blood-brain barrier (BBB) permeability, hindering <i>in vivo</i> im... |
41724131 | Cyclodextrin-siderophore conjugates as a Trojan horse strategy for bacterial targeting. | The rise of antibiotic resistance necessitates the development of innovative strategies to enhance the effectiveness of existing treatments. One promising approach leverages bacterial iron acquisition systems through siderophore-based drug delivery to increase intracellular drug concentrations, a Trojan horse strategy.... |
41722894 | Allosteric drugs in biomolecular condensates: ways forward. | Biomacromolecular condensates are membraneless compartments that form through the dynamic assembly of function-related macromolecules to perform specific functions, such as signaling and gene expression. They have crucial roles in disease, fueling significant interest in their therapeutic potential. Efforts largely foc... |
41722739 | From ascorbic acid to N-acetylcysteine: self-assembled clarithromycin liquid crystals as a new generation of carrier-free antibiotics. | Antimicrobial resistance demands innovative molecular strategies to enhance antibiotic efficacy while minimizing the use of excipients. Building on the previously reported clarithromycin: ascorbic acid cholesteric liquid crystal, we present a new carrier-free system formed via the self-assembly of clarithromycin and N-... |
41720027 | Fungal enzyme-driven precipitation polymerization: Trapping estrogenic chemicals to block vegetable contamination. | Estrogenic contamination in vegetable foods, along with its associated safety implications, has become a growing global concern. Trametes versicolor laccase, a robust multicopper oxidase, efficiently catalyzed precipitation polymerization, promoting the rhizoremediation of four estrogenic chemicals (ECs) in water-lettu... |
41716008 | Modified Polycyclic Compounds Rescue Mis-splicing in Myotonic Dystrophy Type 1 Disease Models. | Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder with no approved therapeutics targeting the disease mechanism. DM1 is caused by the expression of expanded CUG repeat RNA (CUG<sub>exp</sub>), which sequester the muscleblind-like (MBNL) family of RNA binding proteins leading to dysregulate... |
41715991 | Elucidating the Role of Diacid Anions in Governing Cellulose Dissolution and Microstructure of Regenerated Cellulose Aerogels. | Tailoring solvent structures to regulate the dissolution and supramolecular assembly of cellulose is essential for developing advanced functional biobased materials. Herein, novel protic ionic liquids (PILs) composed of 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU) and various diacid anions were systematically investigate... |
41715897 | Orchestrating life's first community: molecular assembly by human milk oligosaccharides. | The infant gut microbiota, orchestrated by human milk oligosaccharides (HMOs), forms a critical foundation for lifelong health. Despite their recognized importance, the molecular strategies through which HMOs govern microbial competition and niche establishment remain poorly understood. Moving beyond ecological observa... |
41715285 | DNA Supramolecular Hydrogel Alters Exosomal microRNA Atlas and Paracrine Secretory Profile of MSCs to Promote Bone Remodeling and Ameliorate Osteoradionecrosis of the Jaw. | Osteoradionecrosis of the jaw (ORNJ) is a severe complication of head and neck radiotherapy, characterized by a hostile tissue microenvironment that hinders healing. To address the limitations of mesenchymal stem cell (MSC) therapy, such as rapid dispersion and clearance, we developed an injectable, shear-thinning DNA ... |
41715288 | Photosystem II-Inspired Ce-MOF for Selectively Coupling Photocatalytic Nitro-to-Azoxy Conversion with Water Oxidation. | The integration of photocatalytic water oxidation with selective organic transformations remains challenging due to inefficient charge separation and intermediate regulation. Inspired by the spatially separated redox centers of photosystem II (PSII), we developed a cerium(IV)-based metal-organic framework (Ce(IV)-<b>DP... |
41715184 | Bioactive eggshell membrane-integrated nanofiber dressing with mesoporous polydopamine-mediated sustained dexamethasone delivery for enhanced wound regeneration. | Wound healing is often impeded by excessive inflammation and oxidative stress, necessitating multifunctional dressings with therapeutic and regenerative properties. Here, a biodegradable nanofiber dressing (PE@MD) composed of poly(L-lactide-co-ε-caprolactone) (PLCL), water-soluble eggshell membrane (ESM), and dexametha... |
41715154 | Innovative mycosynthesis of chitosan nanoparticles via bionanofactory Penicillium crustosum: optimization, characterization, and application against building-deteriorating fungus, Trichosporon asahii. | Biocorrosion of building materials is a global challenge that threatens both modern buildings and cultural heritage. This degradation is largely driven by interactions between microbes, particularly fungi, and various gaseous effluents containing nitrogenous, sulfurous, and carbonaceous aerosols from anthropogenic acti... |
41715107 | Nanomedicine leverages cuproptosis-mediated cGAS-STING activation to enhance antitumor immunity. | The cGAS-STING pathway is a cornerstone of innate immunity, sensing cytosolic DNA to initiate potent type I interferon and inflammatory responses. Its targeted activation represents a promising strategy to overcome cancer immunosuppression and resistance. However, the clinical translation of conventional STING agonists... |
41715076 | Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration. | Intervertebral disc degeneration (IVDD) is driven by severe oxidative stress, a loss of extracellular matrix (ECM) homeostasis, and ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Therapeutic strategies based on microenvironment engineering that can simultaneously combat oxidative damage ... |
41714611 | Vision of Life's Code: Molecular Probe Nanoarchitectonics for Deep RNA/DNA Illumination. | Visualization of RNA and DNA provides a window of opportunity for the early detection of multiple diseases and approaches to manipulate them before any pathological processes occur. However, current imaging systems often fail to meet these demands due to the need for multiple RNA and DNA chemical probes, which increase... |
41714601 | Structural organization of HBV pgRNA genome driven by phase separation in capsid confinement. | Viruses rely on the precise packaging of their genomes within a capsid to execute essential life-cycle events, yet the principles governing genome structural organization in this confined environment remain elusive. Here, we reveal that hepatitis B virus (HBV) pregenomic RNA (pgRNA) exploits liquid-liquid phase separat... |
41714330 | From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2. | Protein language models (PLMs) capture features of protein three-dimensional structure from amino acid sequences alone, without requiring multiple sequence alignments (MSA). The concepts of grammar and semantics from natural language have been suggested to have the potential to capture functional properties of proteins... |
41714322 | Mixed-matrix membranes with molecular recognition windows for selective helium extraction from natural gas. | Mixed-matrix membranes (MMMs) with high chain packing density by incorporating soluble macrocycle compounds represent a promising class of materials for gas separation. However, achieving the ultra-high selectivity (He/CH<sub>4</sub> > 1000) for helium extraction from natural gas with ultra-low helium content remains a... |
41714276 | How Water Exclusion Accelerates Reactions in Enzyme Active Sites and Supramolecular Cavitands. | The mechanism by which enzymes dramatically accelerate reactions remains a scientific grand challenge. Several laboratories recently reported that reactions in low-density interfacial water are orders of magnitude faster than in bulk water <i>in the absence of enzymes</i>. These findings align with previous reports tha... |
41712763 | Open-Architecture Monolayered Metal-Organic Framework for Seamless Enzyme Integration in Photoenzymatic Catalysis. | Metal-organic frameworks (MOFs) have been employed as versatile support platforms for enzyme immobilization and functional moiety integration. However, their intrinsic pore size limitation and synthetic conditions hinder the accommodation of large enzymes and restrict cooperative catalysis between enzymes and embedded ... |
41712723 | Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization. | Pathogenic <i>Bordetella</i> bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of <i>Bordetella</i> carries a C-terminal microtubule-binding domain (FhaB-CT), which is translocated into host cells to prom... |
41712708 | Evolution of error correction through a need for speed. | Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to evolve when selection for fidelity outweighs costs in energy and the speed of replication. We show that when stalling af... |
41712702 | Ultrahigh-Brightness Chiral Lanthanide Organic Framework X-ray Scintillators for Circularly Polarized Luminescence and Advanced Anticounterfeiting. | In this study, the multifunctional chiral lanthanide organic frameworks (Ln-MOFs, <i>RR</i>/<i>SS</i>-Eu-MOFs) with circularly polarized luminescence (CPL), second-order nonlinear optics (NLO), and high-performance X-ray scintillator applications were constructed using chiral ligands and Eu(NO<sub>3</sub>)<sub>3</sub>·... |
41712689 | Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles. | Tumor overexpression of programmed death-ligand one (PD-L1) inhibits immune recognition. Existing monoclonal antibodies are fragile and penetrate tumors poorly, leading to variable outcomes. Antisense oligonucleotides (ASOs) can reduce PD-L1 expression, but require frequent high dosing due to rapid degradation, clearan... |
41712669 | Conformations and sequence determinants in the lipid binding of an adhesive peptide derived from Vibrio cholerae biofilms. | Surface adhesion is critical to the survival of pathogenic bacteria both in natural niches and during infections, often via forming matrix-embedded communities called biofilms. Vibrio cholerae, the causal agent of pandemic cholera, is capable of forming biofilms adhering to both biotic and abiotic surfaces and the biof... |
41712661 | Secondary Structure Bead-Encoded Amphiphilicity Biases Peptide Self-Assembly Prediction in MARTINI Coarse-Grained Simulations. | Sequence-dependent self-assembly of peptides yields ordered supramolecular structures with diverse nanotechnological applications. In the absence of simple design rules linking sequence to supramolecular morphology, coarse-grained molecular dynamics (CG-MD) simulations have become valuable tools for guiding the design ... |
41712660 | High-Performance Semiempirical Excited-State Molecular Dynamics Powered by Graphics Processing Units. | This Letter introduces excited-state molecular dynamics in PYSEQM, a GPU-accelerated semiempirical quantum chemistry engine implemented in PyTorch. The new module enables Born-Oppenheimer molecular dynamics (BOMD) using configuration-interaction singles and random phase approximation for excited states, allowing long t... |
41712624 | Large Library Docking for Polypharmacology. | Polypharmacological molecules are attractive for complex illnesses. Here, we explored large library docking for joint activity against target pairs. Retrospectively, as libraries grew, so too did the number of likely dual-activity molecules. In prospective docking of a 900-million molecule library against three target ... |
41712309 | Ferroelectricity through Reversible Anion-Relay Polarization Switching in a Two-Dimensional Metal-Organic Framework. | Ferroelectric materials are central to next-generation electronics and energy technologies because of their ability to couple electrical, mechanical, and thermal signals. Metal-organic frameworks (MOFs) provide a versatile platform for such functionalities owing to their structural tunability; however, despite notable ... |
41712065 | Bridging cancer therapies: the role of magnetic nanoparticles in combination cancer therapy. | Despite the efforts of the medical and research community for effective treatments, cancer is one of the leading causes of death worldwide. Cancer cells' enduring resistance is a significant cause of treatment failure. One of the most effective approaches proposed to overcome this resistance is a combination therapy. T... |
41711853 | Detection of alkaline phosphatase activity based on ATP hydrolysis and CRISPR/Cas12a. | Alkaline phosphatase (ALP) activity serves as a crucial biomarker for livestock disease diagnosis, nutritional management, and the evaluation of milk pasteurization efficacy, holding significant implications for food safety and food science. In this study, we developed a novel method for detecting ALP activity in food ... |
41711684 | Exploring Size-Controlled Exciton Evolution Using DNA Libraries. | To investigate multichromophore phenomena, progress traditionally relies on model covalent dimers for spectroscopic interrogation. Integrating molecular semiconductors into nucleic acid libraries can enable rapid screening of multichromophore phenomena. Here, we report DNA-directed assembly of up to five π-conjugated c... |
41711641 | Supramolecular Polymers Controlled by Glycan Geometry. | Despite the crucial roles of glycan structures in glycosylated macromolecules such as proteoglycans in the extracellular matrix, their regulatory mechanism is still poorly understood, due to the complex structures and dynamic interactions of polysaccharides. Here, supramolecular polymers were employed as simplified mim... |
41711589 | Metal Organic Framework Derived Porous BiFeO<sub>3</sub>/PVDF Composites for Synergistic Piezo-Photocatalytic Degradation of Rhodamine B. | Photocatalysis and piezocatalysis rely on light energy and mechanical energy (via the piezoelectric effect) as driving forces, respectively. Both have been successfully applied to pollutant degradation and wastewater treatment as advanced oxidation processes. However, in this study, BiFeO<sub>3</sub> nanoparticles deri... |
41711440 | Within-host evolution drives the emergence of ceftazidime-avibactam resistance mediated by IncN plasmid-encoded <i>bla</i><sub>NDM-1</sub> and <i>bla</i><sub>KPC-33</sub> in ST11-KL64 hypervirulent <i>Klebsiella pneumoniae</i>. | Ceftazidime-avibactam (CZA) is considered one of the most effective antimicrobial agents for treating infections caused by <i>Klebsiella pneumoniae</i> carbapenemase-producing <i>Klebsiella pneumoniae</i>. However, rising CZA resistance poses a critical clinical challenge, primarily driven by <i>bla</i><sub>KPC</sub> m... |
41711417 | Rational Design and Interfacial Engineering of an MOF-on-MOF-Derived Fe<sub>3</sub>O<sub>4</sub>@NiCo<sub>2</sub>S<sub>4</sub> Hollow Spindle-Shaped S-Scheme Heterojunction for Excellent CO<sub>2</sub> Photoreduction. | The development of S-scheme heterojunctions offers a powerful approach for efficient photocatalytic CO<sub>2</sub> reduction, leveraging enhanced charge separation and strong redox capabilities. However, efficient interfacial charge transfer continues to pose significant challenges. In this work, we designed unique Fe<... |
41711299 | Receptor-Free Cellular Internalization of DNA Micelles Driven by Membrane Interaction. | Cellular uptake of nanoparticles is essential for significant therapeutic effects at the target site in drug-delivery applications. Various endocytosis pathways have been reported; however, the internalization of nanoparticles depends on their physical and chemical properties. We previously developed nucleic acid-based... |
41709870 | Label-Free MicroRNA Diagnostics: From CRISPR Nucleases to Nanomaterial-Enhanced Transducers. | Label-free detection of microRNAs (miRNAs) has emerged as a pivotal approach in molecular diagnostics, integrating the programmability of CRISPR systems with the high sensitivity of nanomaterial-based transduction. miRNAs are short, noncoding RNAs that play central roles in gene regulation and disease pathogenesis, ser... |
41709858 | Multi-Level Confinement Single-Molecule Charge Transfer Activated PRET for Near-Infrared Targeted Cell Imaging. | This work reports an interesting phosphorescent resonance energy transfer (PRET) system with a large Stokes shift (320 nm) and near-infrared (NIR) delayed fluorescence emission for high-performance bioimaging, where a tailored charge transfer supramolecular assembly was constructed from dibenzyl-bridged pyridinium deri... |
41709778 | Intermingled Coordination Environments Enable Defect-Engineered Metal-Polyphenol/G-Quadruplex Hydrogel for Enhanced N<sub>2</sub>-to-NH<sub>3</sub> Photoconversion. | Manipulating the coordination environment through hetero-ligand incorporation induces controlled defects at catalytically active sites, offering a powerful route to regulate electronic structure and reactivity. Here, we present a supramolecular approach to defect engineering within a soft hydrogel matrix by confining a... |
41709737 | Flexibility Induced by Four Heptagons: A Negatively Curved Polycyclic Aromatic Hydrocarbon Cut-Out of Schwarzite P216. | A key feature of the, so far only theoretically described, family of sp<sup>2</sup> carbon allotropes called <i>schwarzites</i> is the negatively curved topology, which is introduced by the incorporation of heptagonal (or octagonal) rings in a graphene-type lattice. We have constructed a cut-out of this material with a... |
41709304 | Microbiota-derived propionate suppresses Salmonella virulence gene expression via LuxS quorum sensing. | <h4>Background</h4>Despite mounting evidence that commensal microbes enhance host defenses, whether and how they directly suppress pathogen virulence remains elusive. Here, we investigate metabolites from the gut microbiota of infection‑resistant Tibetan chickens for their ability to reduce Salmonella virulence gene ex... |
41709219 | Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery. | Spherical nucleic acids (SNAs) represent a class of nanomaterials typically composed of a nanoparticle (NP) core functionalized with a dense shell of oligonucleotides. This architecture confers several advantageous properties, including enhanced cellular uptake, high nuclease stability, low immunogenicity, and minimal ... |
41709202 | Artificial intelligence-driven nano-enhanced stem cell therapy for neurodegenerative diseases: from rational design to clinical translation. | Neurodegenerative diseases (NDs) are progressive and incurable central nervous system disorders characterized by the accumulation of pathological proteins and the loss of neurons. Although stem cell transplantation offers a new treatment option, its clinical application is severely hindered due to imprecise delivery, l... |
41708606 | Discovery of tunable and soluble organic emitters for solid-state lasers with a self-driving laboratory. | We have recently demonstrated the ability of using self-driving laboratories for AI-driven searches of organic emitters for solid-state lasing devices. Our past workflow featured solubility challenges for such large molecular moieties. In this next-generation study, we return to the drawing board to explore a family of... |
41649008 | Boosting room-temperature phosphorescence <i>via</i> polarity-induced through-space conjugation in a host-guest doping system. | We propose a strategy in which polar guest molecules induce through-space conjugation to enhance the room-temperature phosphorescence performance of a host matrix in a host-guest doping system. By incorporating polar coumarin derivatives into aromatic carboxylic acid, strong intermolecular interactions were established... |
41642054 | A MOF with high specific surface area for rapid separation and determination of β-adrenergic receptor blockers in pork by open-tubular capillary electrochromatography. | In this work, a novel Ti-based MOF (NH<sub>2</sub>-MIL-125) bonded open-tubular (OT) column was firstly prepared <i>via</i> a one-step bonded growth method for capillary electrochromatography (CEC). The stationary phase was characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, X-ray di... |
41641949 | Lewis acidity driven fluorochromism in a lanthanide MOF for highly selective Zr(IV) detection. | A fluorochromic Eu-based MOF is developed for highly selective Zr(IV) detection. Leveraging the strong Lewis acidity of Zr(IV), competitive coordination to carboxylate sites induces framework dissociation, disrupts ligand-to-metal energy transfer, and produces a distinct red-to-blue luminescence shift, enabling sensiti... |
41601184 | A mesoporous two-dimensional cobalt-phosphonocarboxylate metal organic framework (Co-MOF) as an efficient and recyclable catalyst for solvent-free multicomponent reactions. | A novel two-dimensional cobalt(II)-based metal-organic framework (Co-MOF) was synthesized using combined solvothermal and sonochemical methods. The structure of the compound, [Co(HL)(bipy)(H<sub>2</sub>O)]<sub><i>n</i></sub> (H<sub>3</sub>L = <i>m</i>-(phosphonomethyl)benzoic acid), was determined by single-crystal X-r... |
41563250 | pH-Responsive peptide nanopores are stabilized by lipid and water-mediated hydrogen bonding networks. | Membrane-spanning nanopores that allow controlled passage of macromolecular cargo across cell membranes can empower many biomedical applications. Such nanopores are formed, in a pH-responsive manner, by the synthetically evolved "pHD peptide" family. pHD peptides fold into amphipathic α-helices, but have many charged a... |
41563045 | Self-assembled chromopeptide nanostructures for photothermal therapy of tumors. | Drawing inspiration from the elegant molecular machinery and unique light-handling functions of natural chromoproteins, this review focuses on the rational design of self-assembling chromopeptides as a versatile platform to address the enduring challenges of photothermal therapy (PTT) for tumors. These programmable con... |
41294381 | Reducing rotatable bonds in one substrate accelerates a bimolecular Diels-Alder reaction in a bis-calix[4]pyrrole cage. | We report the quantitative self-assembly of an endohedrally functionalized octa-imine cage from two calix[4]pyrrole scaffolds <i>via</i> dynamic covalent chemistry. The cavity combines size and shape complementarity with enzyme-like directional guest binding. Acting as a molecular flask, the cage stereoselectively prom... |
40844415 | From Polymerization-Enabled Folding and Assembly to Chemical Evolution: Key Processes for Emergence of Functional Polymers in the Origin of Life. | Chemical and geological processes on prebiotic Earth are believed to have resulted in the emergence of life through the increasing organization and functionality of organic molecules. This primer provides an overview of some key abiotic chemical and physical processes that could have contributed to life's building bloc... |
41988367 | Development of Cathepsin B‑Activatable Cell-Penetrating Peptides for Tumor Targeting. | Extracellular cathepsin B is a driver of tumor progression and metastasis, and its potential as a diagnostic and prognostic marker is increasingly recognized. To harness its activity for triggering the uptake of activatable cell-penetrating peptides (ACPPs) <i>in vivo</i>, kinetically suitable and stable endopeptidase ... |
41909641 | Analysing heat transport in crystalline polymers in real and reciprocal space. | Heat transport can be modelled with a variety of approaches in real space (using molecular dynamics) or in reciprocal space (using the Boltzmann transport equation). Employing two conceptually different approaches of each type, we study heat transport in crystalline polyethylene and polythiophene. We find that consiste... |
41853650 | Visualizing Dynamic Processes in Energy Materials by Interferometric Scattering Microscopy. | Interferometric scattering microscopy (iSCAT) is emerging as a powerful label-free optical method to directly visualize nanoscale dynamics in real time. While it catalyzed major progress in single-molecule studies in life sciences, its broader potential in chemistry and materials science is only beginning to unfold. Th... |
41846078 | Multi-omics analysis revealed that oxidative phosphorylation contributed to the heterosis for feed efficiency in laying chickens. | Improving feed efficiency has been the top priority in animal husbandry. Host genetics and gut microbiota synergistically regulate feed efficiency in laying chicken. However, the role of gut microbiota in heterosis for feed efficiency was rarely investigated. Herein, we used multi-omics data to elucidate the regulatory... |
41834828 | Dual-Pathway Strategy for Click-Type Functionalization and Programmable Polymer Deconstruction. | Developing polymeric materials that combine precise, modular functionalization with programmed backbone degradability remains an outstanding challenge in macromolecular engineering. Herein, we present a molecular design strategy that integrates orthogonal postpolymerization modification with selective, stimulus-respons... |
41810066 | Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy. | Neuroinflammation plays a critical role in cerebral ischemic injury, making it an important therapeutic target for stroke treatment. Ganoderic acids (GAs), the primary bioactive compounds isolated from <i>Ganoderma lucidum</i>, exhibit well-demonstrated anti-inflammatory properties. This study aimed to investigate the ... |
41809371 | Antigen-binding affinity is a key determinant of the durable antitumor activity of CD5 CAR-T cells. | T cell fratricide in T cell antigen-targeted chimeric antigen receptor (CAR)-T cell therapies remains a critical barrier to achieving optimal antitumor efficacy. To address this challenge, we explored modulation of antigen-binding affinity as a simple yet effective strategy to mitigate fratricide. To this end, we aimed... |
41799203 | OSBPL3-driven sterol metabolic reprogramming promotes oncogenic signaling and therapeutic resistance in pancreatic cancer. | <h4>Background</h4>As a member of the oxysterol-binding protein-like (OSBP) family, which is primarily involved in lipid transport and metabolic regulation, Oxysterol-binding protein-like protein 3 (OSBPL3), has garnered increasing attention due to its abnormal expression and functional roles in various cancers. Howeve... |
41799118 | Poly(2-oxazoline)-Based Lipid Nanocapsules Containing Free Hydroxyl Group as Promising Alternative to Conventional PEG-Lipid Nanocapsules. | Lipid nanocapsules (LNCs) are attractive nanocarriers owing to their high colloidal stability and cytocompatibility. However, their current formulation relies on the poly-(ethylene glycol) (PEG)-based surfactant Kolliphor HS 15, whose clinical use is increasingly compromised by the emergence of anti-PEG antibodies lead... |
41799097 | High-Quantum-Yield [Eu(Phen)<sub>2</sub>(NO<sub>3</sub>)<sub>3</sub>] Phosphor Exhibiting Zero Thermal Quenching under Real Operating Conditions (30-150 °C). | In this study, we present the first investigation of the temperature-dependent luminescence properties of the [Eu-(Phen)<sub>2</sub>(NO<sub>3</sub>)<sub>3</sub>] complex across the 30-150 °C range. The coordination environment, thermal stability, and structural analysis of the complex were studied by Fourier-transform ... |
41799085 | Sustainable Nanocellulose Extraction from <i>Salacca zalacca</i> Peel Using Chlorine-Free and Low-Acid Treatments. | Conversion of agro-waste to value-added products is one of the important principles of a green circular economy. A novel sustainable technique has been reported by using chlorine-free extraction of cellulose nanofibers (CNFs) from the peels of <i>Salacca zalacca</i>, a common fruit found in Asia. The fruit peels were e... |
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