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41789091 | Structural and temporal dynamics of nano-based therapies in ulcerative colitis: history, hotspots, and emerging trends. | <h4>Background</h4>Nanomaterial-based therapies have emerged as a promising approach for ulcerative colitis (UC). To systematically map the field, we performed a bibliometric analysis of research over the past 25 years, aiming to reveal knowledge evolution, core themes, and emerging trends.<h4>Methods</h4>We searched t... |
41789085 | Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and <i>in silico</i> study involving HLA-DRB104:02 and 14:01. | <h4>Introduction</h4>Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease characterized by autoantibodies directed against the desmosomal cadherins desmoglein 3 (DSG3) and desmoglein 1 (DSG1), which are essential for keratinocyte adhesion. While the pathogenic role of these autoantibo... |
41789059 | Framework-mediated binding of foreign and self-glycans by IGHV4-34 antibodies. | Cold agglutinin disease is an autoimmune condition characterised by expression of self-reactive antibodies to I/i carbohydrate blood group antigens (polymers of N-acetyllactosamine or 'LacNAc' units) resulting in anaemia through the agglutination and complement-mediated destruction of red blood cells. This antibody res... |
41788687 | The multi-target protective effects of quercetin in cerebrovascular diseases: a dietary strategy for endothelial repair and neuroprotection. | Cerebrovascular diseases, including ischemic stroke and vascular cognitive impairment, represent a significant global health challenge due to the paucity of effective treatment options. Quercetin, a dietary flavonol, has emerged as a promising multi-target neuroprotective compound. This review elucidates the core mecha... |
41788684 | Exploratory multi-omics analysis of gut microbiota and fecal metabolites in relation to serum S-equol levels in older adults with osteoporosis from a tropical community: a pilot study. | <h4>Background</h4>Osteoporosis (OP) is a multifactorial skeletal disorder influenced by host metabolism, inflammation, and gut microbiota-derived metabolites such as S-equol. However, the interplay between intestinal microbiota, S-equol production, and host metabolic profiles in OP remains incompletely understood.<h4>... |
41788628 | Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases. | Succinylation is a novel post-translational modification involving the attachment of a negatively charged succinyl group to lysine residues, which fundamentally alters the structure and function of substrate proteins. The liver, the metabolic center of the body, is a critical target for succinylation because of its hig... |
41788398 | <i>Staphylococcus epidermidis</i> DnaK alters biofilm formation and proteome in <i>Staphylococcus aureus</i> CIP 107093. | <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>, two Gram-positive bacteria of the human skin microbiota, form biofilms that contribute to dysbiosis and inflammatory skin diseases such as psoriasis and atopic dermatitis. The human calcitonin gene-related peptide (CGRP), involved in skin inflammation,... |
41788333 | Omics-driven research progress on phosphate activation mechanisms and stress adaptability regulation of Phosphate-Solubilizing Microorganisms (PSMs). | Phosphorus (P) is an indispensable macronutrient for crop growth and development, but most phosphorus in soil exists in insoluble forms with extremely low availability. Although the application of traditional chemical phosphorus fertilizers can meet the phosphorus demand of crop growth, the extensive exploitation of ph... |
41788328 | Study of grapevine endophytes' interaction with the host and their potential as biocontrol agents as sustainable alternative to agrochemicals. | In sustainable vineyard management, biocontrol agents (BCAs) offer a promising alternative to chemical pesticides. This study focuses on characterizing endophytes isolated from grapevines in different regions of northern Italy for (i) their effectiveness against <i>Botrytis cinerea</i> through <i>in vitro</i> tests and... |
41777799 | Comparative effects of high-intensity interval training at low and moderate altitudes on 5000-m performance and perceptual responses: A randomized controlled trial. | <h4>Background/objectives</h4>Hypoxia compromises training quality, yet high-intensity interval training (HIIT) performed under hypoxia may elicit greater benefits than does normoxic HIIT. However, its effects on pacing and perceived exertion remain underexplored, particularly in moderate-altitude distance runners. Thi... |
41777582 | Microalgal therapeutic peptides: From biomass to bone tissue engineering. | Bone tissue engineering continues to face challenges in developing biomaterials that are both safe and biologically active, particularly in promoting integration with native tissue. Traditional synthetic materials often lack cellular compatibility, driving research toward natural and biomimetic alternatives. In this co... |
41767816 | Near-infrared-to-deep-blue photon upconversion engineered from PbS quantum dots and perylene derivatives. | Near-infrared (NIR)-to-visible light triplet-triplet annihilation photon upconversion (TTA-UC) holds great promise for solar energy harvesting, photochemistry, and bioimaging. However, achieving a large apparent anti-Stokes shift from the NIR to the blue region remains highly challenging. Here, we present the first TTA... |
41767651 | Improved rehydration characteristic of micellar casein powder by electrostatic spray drying. | Micellar casein (MC), a key protein derived from milk, is extensively utilized in the food sector. Nevertheless, the practical application of MC powder is constrained by its inadequate rehydration performance. This study investigated the effect of electrostatic spray drying (ESD) on the rehydration properties of MC pow... |
41756689 | ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells. | Cervical spondylosis and low back pain caused by intervertebral disc degeneration (IVDD) are among the leading causes of clinical disability. Although excessive reactive oxygen species (ROS) are established drivers of IVDD, the mechanisms linking ROS accumulation to disc cell dysfunction, cell death programs, and disru... |
41756688 | Advances in delivery technologies-powered cancer vaccines. | Over the past decade, cancer vaccines have shown great promise in immunotherapy for solid tumors. However, the efficacy of cancer vaccines is unsatisfactory due to the complexity, heterogeneity, and immune evasion of cancer, as well as the instability of the core components of the vaccines (antigens and adjuvants), the... |
41756358 | 2'-Fucosyllactose and its metabolites propionate/butyrate suppress inflammation through a shared TLR4/p38 MAPK-dependent pathway <i>in vitro</i> and <i>in vivo</i>. | 2'-Fucosyllactose (2'-FL), the most abundant human milk oligosaccharide (HMO), exhibits potent anti-inflammatory properties, yet the underlying mechanisms remain incompletely understood. This study employed an integrated approach combining <i>in vitro</i> fermentation systems, Caco-2 cell assays, <i>in vivo</i> murine ... |
41756152 | Peptide-based artificial cytoskeleton enhances colocalized cascade reactions in cell-like microreactors. | We report the formation of an artificial cytoskeleton within droplet-based protocells, which dramatically increases the efficiency of a cascade reaction. The cytoskeleton is formed <i>via</i> self-assembly of a short peptide phenylalanine-phenylalanine-methionine (FFM) in the confinement of cell-sized water-in-oil drop... |
41756023 | P450 engineering via structure-guided rational design achieves high C21-selectivity and bioconversion in steroid biosynthesis. | C21-hydroxylation is a crucial step in the synthesis of corticosteroids. For instance, C21-hydroxylase catalyzes the conversion of progesterone (PRO) into 11-deoxycorticosterone (DOC, the precursor of cortisol and aldosterone). Through structure-guided rational design combined with focused rational iterative site-direc... |
41756012 | Immunoinformatic-driven design of a multi-epitope vaccine against <i>Helicobacter</i> <i>pylori</i>. | <i>Helicobacter pylori (H. pylori)</i> is present in the gastric mucosa of approximately half of the global population and is classified as a definitive type I carcinogen. Developing a logical and effective vaccine against <i>H. pylori</i> remains a critical need. To enhance immune protection, a multi-epitope vaccine w... |
41753917 | The Evolution of Lithography: From Resolution Scaling to Manufacturing Constraints. | Lithographic patterning continues to evolve under the dual pressure of ever-finer features and manufacturable, cost-effective integration. Beyond headline resolution, industrial adoption is increasingly determined by a small set of coupled metrics: throughput, overlay (registration), defectivity, and cost, as well as b... |
41752106 | Jurkat T-Cell Antigen-Independent Elimination of PMA-Activated Neuroblastoma Cells Is Triggered by CCL2/CCR2, Depends Upon Lipid Raft LFA1/ICAM1 Immune Synapses, Is Mediated by m-TRAIL and Is Augmented by the TrkAIII Oncoprotein. | Advances in multimodal therapy for high-risk neuroblastomas (NBs) have plateaued, prompting therapeutic initiatives to harness the immune system. NBs, however, are immunologically "cold" and a significant challenge to immunotherapy. Here, in a Jurkat lymphocyte cytotoxicity model, we describe an antigen-independent, ce... |
41752074 | Milk-Derived EVs from Different Animal Sources: An Overview on Their Detection, Isolation and Pleiotropic Exerted Effects. | Milk is a primary source of vital nutrients and bioactive components fundamental to the growth and development of both newborn animals and humans. Produced by economically significant livestock species (including cattle, buffaloes, goats, sheep and camels), milk is a complex matrix rich in caseins, vitamins, fats, and ... |
41751482 | Exploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning. | Neohesperidin dihydrochalcone (NHDC) is a synthetic sweetener derived from neohesperidin and can improve pathological changes in sepsis-associated acute lung injury (SALI), but the mechanism by which NHDC inhibits SALI remains unclear. We evaluated the therapeutic effect of NHDC (100 mg/kg) and its potential mechanism ... |
41743638 | Supramolecular protecting groups can impart prosthetic stereoselectivity to catalytic systems employing unmodified achiral heterogenous catalysts. | Use of homogeneous catalysis - typically based on scarce precious metals - remains a dominant approach to afford good yields of enantiopure compounds. Combining typical strengths of heterogenous catalysts (low cost, sustainable, recyclable) with those of precious metal-mediated homogenous catalysis (amenability to desi... |
41740444 | sQTLs and eQTLs for growth in broilers identification and characterization of sQTLs and eQTLs associated with growth traits in yellow-feathered broilers. | In-depth investigation of genetic variants influencing muscle yield in chickens is crucial for maximizing the efficiency of improving production performance in local chicken breeding programs. To identify variants and genes affecting muscle yield in Chinese indigenous chickens, we performed a genome-wide association st... |
41745184 | Research Progress on Nanopolymer Composites in Civil Engineering. | Civil engineering infrastructure suffers material degradation, shortened service life and high maintenance costs under harsh environments and natural aging, threatening public safety. Nanopolymer composites, featuring designable microstructures and excellent macroscopic properties, provide a revolutionary solution to i... |
41744596 | Virus Biomimetic-Delivery Systems for the Production of Vaccines. | The persistent emergence of infectious diseases has underscored the critical demand for next-generation vaccine technologies that are safe, effective, and scalable. This review explores virus biomimetic delivery systems, focusing on virus-like particles (VLPs) and virosomes as promising platforms for vaccine and therap... |
41738060 | Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and Therapeutic Frontiers. | Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation, critically contributes to cerebral ischemia/reperfusion (I/R) injury. In ischemic stroke, neuronal ferroptosis arises from iron overload and antioxidant system failure. Excessive Fe<sup>2</sup>⁺ fuels hydroxyl radical production via the Fen... |
41730825 | Metal-organic frameworks and their derivatives for CO<sub>2</sub> electrocatalysis: From methods and designs to products. | Curtailing atmospheric CO<sub>2</sub> from industrial processes and automobiles remains a pressing issue to be addressed in alleviating the existential threats of climate change. To this end, the electrochemical CO<sub>2</sub> reduction reaction (eCO<sub>2</sub>RR) route, which utilizes metal-based catalysts to convert... |
41730253 | Insight into the oxidation mechanism of low-salt Sichuan-style sausages treated with inclusion complexes of tea-polyphenol/β-cyclodextrin/NaCl and electron beam irradiation using machine learning algorithms. | Low-salt sausages are gaining popularity due to health risks from high salt intake. In this study, the effects of electron beam irradiation (EBI) at various doses (0, 3, 6 kGy) combined with inclusion complexes (ICs) of tea-polyphenol/β-cyclodextrin/NaCl on the quality of low-salt Sichuan-style sausages during ambient ... |
41720401 | Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2<sup>V617F</sup> mice. | The Jak2<sup>V617F</sup> (Jak2<sup>VF</sup>) mutation is an important cause of both clonal hematopoiesis of indeterminate potential (CHIP) and myeloproliferative neoplasms (MPNs). Mouse models of Jak2<sup>VF</sup> CHIP and MPN show accelerated atherosclerosis progression, driven by macrophage inflammasome activation. W... |
41720373 | Eco-engineered sodium alginate-bentonite-Fe-ATA aerogels with tunable crosslinking for high-efficiency cationic dye adsorption. | Sodium alginate (SA)-based aerogels and MOF materials have been well documented for dye removal, yet both materials face fundamental limitations that hinder their use in real waters. SA exhibits a single type of adsorption site in its unmodified form, whereas MOFs suffer structural damage upon long-term exposure to aqu... |
41720346 | Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus. | Swine enteric coronaviruses (SECoVs) cause severe watery diarrhea and high mortality in piglets, resulting in significant economic losses to the global pig industry. However, frequent mutations in SECoVs significantly compromise vaccine-induced immunity and limit cross-protection against emerging variants. Therefore, t... |
41720020 | Machine learning-integrated metal-organic frameworks/multi-walled carbon nanotubes sensor array for real-time detection of fungal VOCs. | Biological hazards posed by indoor fungi present significant challenges due to their hidden growth and the limitations of conventional detection methods. As an alternative, microbial volatile organic compounds (MVOCs) offer a non-invasive proxy for early-stage fungal contamination. This study presents a multi-modal gas... |
41719668 | Template derivatization-mediated synthesis of highly ordered paper-based imprinted chip for enhanced sulfadiazine analysis. | Molecularly imprinted polymers (MIPs) have gained significant traction in food contaminant analysis owing to their tailorable binding sites and functionalities. Nevertheless, the analysis performance of MIPs fabricated via conventional imprinting methods has been hindered by heterogeneous binding cavities. Herein, we f... |
41717257 | Aluminium MOF as a selective sensor for atrazine with docking and computational insight. | An aluminium-based metal-organic framework (Al-MOF), constructed using 2,6-naphthalenedicarboxylic acid (2,6-NDC) as a linker, was synthesized for the selective electrochemical detection of atrazine (ATZ) in water. This study explores the molecular interactions between the Al-MOF and ATZ, supported by docking simulatio... |
41717260 | Carbon nanodots as theranostics agents in cancer: advances in design, targeting, and real-time monitoring. | Carbon nanodots (CNDs) have emerged as a promising class of carbon-based nanomaterials for cancer theranostics, uniquely integrating diagnosis and therapy on a single platform. Their ultrasmall size, high aqueous dispersibility, tunable photoluminescence extending into the near-infrared (NIR) window, and compatibility ... |
41717248 | Theoretical insights into the stability and nature of nonconventional C-H⋯Y (Y[double bond, length as m-dash]N, P, As, Sb) hydrogen bonds in haloform-pnictogen trihydride complexes. | In this study, we investigate the stability and intrinsic nature of nonconventional C-H⋯Y hydrogen bonds (Y[double bond, length as m-dash]N, P, As, Sb), with special attention given to the largely unexplored C-H⋯P interaction and the first theoretical observation of C-H⋯As/Sb interactions in complexes formed between ha... |
41717246 | A review of self-healing mechanisms for the application of conductive electronic products. | The rapid growth of electronic devices has raised concerns about durability and e-waste. Self-healing materials offer a promising solution by extending device lifespan and reducing maintenance needs. This review examines the use of self-healing materials in conductive electronic systems, focusing on intrinsic and extri... |
41717242 | The influence of the substituent type and position on the topology of 2-D heterometallic sodium-palladium(ii) coordination networks with substituted nicotinate ligands. | Two 2-D heterometallic sodium-palladium(ii) coordination networks with 2-methylnicotinate (2-methylpyridine-3-carboxylate, 2-Menic) and 6-fluoronicotinate (6-fluoropyridine-3-carboxylate, 6-Fnic) ligands, {[Na<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>(µ-H<sub>2</sub>O)<sub>4</sub>PdCl<sub>2</sub>(µ-2-Menic-N:O')<sub>2</s... |
41717243 | Nanozymes based on functionalized iridium oxide-modified gold nanoparticles for combination therapy. | Combination therapy has become the trend in cancer treatments. Iridium oxide-based nanoparticles have shown potential for application in tumour therapy due to their excellent photophysical-chemical and hydrogen peroxide-like enzymatic activities. However, during the practical application of functionalized iridium oxide... |
41716249 | Machine learning guided discovery of water stable metal-organic frameworks for photocatalytic hydrogen production. | With remarkably tunable porosity and modular chemistry, metal-organic frameworks (MOFs) present a versatile platform for photocatalytic hydrogen (H<sub>2</sub>) production. However, identifying high-performing and water stable MOFs from the vast design space is challenging. In this study, we develop a hierarchical scre... |
41716245 | Convenient large-area construction of flexible multicolor polymer-based room temperature phosphorescence materials with second-scale phosphorescence lifetimes. | The preparation of multicolor organic room temperature phosphorescence (RTP) materials with flexibility and second-scale phosphorescence lifetime is highly attractive yet remains extremely challenging. Here, we synthesize a series of carbazole-functionalized polyacrylamide copolymers P(AM-<i>co</i>-VBC) by free radical... |
41713232 | Sodium valproate induces chromatin remodeling in U-251MG glioblastoma cells. | The development and progression of glioblastoma, the most aggressive malignant intracranial tumor with a poor prognosis, are influenced by mutations, oncogene overexpression, and epigenetic factors, particularly those relating to DNA methylation status and histone post-translational modifications. Valproic acid (VPA), ... |
41709662 | Calix[5]arene Functionalized Gold Nanoparticles for the Selective Detection of Polyammonium Species in Water. | The development of sensors capable of selectively detecting polyamines in aqueous environments is crucial for early and noninvasive disease diagnostics. These aliphatic cations participate in fundamental cellular processes, and their dysregulation has been linked to several cancers and neurodegenerative disorders. Alth... |
41709540 | Unusually Strong Cooperative Noncovalent Binding of Elemental Mercury by Protonated Melamine: A Density Functional and Coupled-Cluster Study. | The noncovalent capture of elemental mercury (Hg<sup>0</sup>) is challenging due to its closed-shell electronic structure and weak affinity for most molecular hosts. Using density functional theory supported by wave function benchmarks, we examine the interaction of Hg<sup>0</sup> with protonated melamine in the gas ph... |
41709537 | Supramolecular Wood-Based Human-Computer Interaction Interface for Text Recognition. | Text recognition is a cornerstone of human-computer interaction (HCI), yet conventional isotropic sensing interfaces are intrinsically constrained in resolving the complex directional features of handwriting, particularly the intricate stroke orientations of Chinese characters. Here, leveraging the intrinsic anisotropi... |
41709407 | Mechanistic Insight into the Origin of Stereoselectivity in NHC-Catalyzed [3 + 3] Annulation of Enal with Enamine. | In this study, the reaction mechanism and the origin of stereoselectivity in the NHC-catalyzed [3 + 3] annulation between an enal and an enamine are thoroughly investigated using density functional theory (DFT) calculations. The acylazolium intermediate plays a pivotal role in the subsequent transformation. Notably, bo... |
41709368 | Regulating Peptide Self-Assemblies by Halogen Bonding and Other Halogen Effects. | This work demonstrates the modulation of peptide self-assembly by halogen bonding (XB) and other halogen effects in synergy with the orthogonal hydrogen bonding of the peptide backbone. Three pentapeptides (featuring a common self-assembling FFK (phenylalanine-phenylalanine-lysine) motif were synthesized. Two peptides ... |
41709366 | A Supramolecular Strategy to Modulate the Photoluminescence of Metallofullerenes via Motion-Induced Phosphorescence Attenuation. | Yttrium-based metallofullerenes have attracted much attention due to their typical photoluminescence properties with thermally activated delayed fluorescence (TADF) and phosphorescence, which have the potential for photofunctional materials. In this work, a supramolecular strategy to modulate the TADF and phosphorescen... |
41709294 | Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing. | Current clinical management of fractures relies largely on surgical intervention and systemic pharmacotherapy, both of which are frequently associated with side effects and largely neglect early microenvironmental abnormalities. Precise elimination of senescent cells at the early stage may offer a more efficient means ... |
41708873 | Critical shifts of fluids in shale nanopores under confinement effects using a modified Redlich Kwong equation of state. | Shale oil or gas, as emerging focal points in current exploration and development activities, have garnered extensive attention from the global energy industry regarding their commercial exploitation. The widespread distribution of nano-scale pores and micro-scale fractures in shale reservoirs results in markedly heter... |
41708867 | Accurate predictions of disordered protein ensembles with STARLING. | Intrinsically disordered proteins and regions (collectively IDRs) are found across all kingdoms of life and have critical roles in virtually every eukaryotic cellular process<sup>1</sup>. IDRs exist in a broad ensemble of structurally distinct conformations. This structural plasticity facilitates diverse molecular reco... |
41708858 | Integrase anchors viral RNA to the HIV-1 capsid interior. | HIV-1 integrase (IN) promotes encapsulation of viral genomic RNA into mature viral cores, and this function is a target for ongoing antiretroviral drug development efforts<sup>1-3</sup>. Here we determined the cryogenic electron microscopy (cryo-EM) structure of a primate lentiviral IN in a complex with RNA, revealing ... |
41708730 | Validation and fine mapping of qVmunBr6.2 locus reveal a gene encoding hevamine-A, a defense protein with chitinase activity, is associated with bruchid (Callosobruchus maculatus) resistance in black gram (Vigna mungo). | Callosobruchus maculatus (cowpea weevil) is an insect pest that causes significant yield loss in cultivated black gram (Vigna mungo var. mungo) during storage. A previous study showed that seed resistance to C. maculatus in wild black gram (V. mungo var. silvestris) accession 'TC2210' is controlled by two linked QTLs, ... |
41708642 | High-spin transition metal atoms drive acidic oxygen evolution reactions. | Synthesizing transition metal catalysts to replace precious metal ones such as IrO<sub>2</sub> and RuO<sub>2,</sub> achieving efficient acidic oxygen evolution reaction while balancing intrinsic activity, stability, and cost-effectiveness always been a dream pursued by scientists and industrialists, but still remains a... |
41708632 | Poly(vinyl alcohol) induced chirality inversion and amplification of circularly polarized room-temperature phosphorescence in homopolypeptide aggregates. | Organic circularly polarized room-temperature phosphorescence (CPRTP) materials represent an emerging research frontier with broad application prospects. However, achieving efficient and controllable CPRTP remains challenging due to inefficient chirality transfer and the limited ability to regulate chiral environments.... |
41708627 | Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging. | Aging is a major risk factor for diabetic kidney disease (DKD), with both conditions exhibiting similar renal pathology. We identify the energy-sensing molecule Retinoic acid-related orphan receptor γ (RORγ) as significantly downregulated in diabetic and aged kidneys. Tubule-specific RORγ deficiency exacerbates kidney ... |
41708603 | cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis. | Self-DNA triggers cGAS-STING-mediated type I interferon (IFN-I) to induce both protective and pathogenic immune responses; however, how self-DNA activates the cytosolic cGAS-STING pathway remains unclear. Here we show that the cGAS/STING/IFN-I axis is activated by self-DNA via a process termed 'nucleocytosis', in which... |
41708601 | High Open-Circuit Voltage-Fill factor product in perovskite solar cells enabled by ferroelectric heterojunction modulation. | Overcoming the inherent limitations of perovskite-perovskite heterojunctions in simultaneously boosting built-in potential and suppressing non-radiative recombination remains a critical challenge in perovskite solar cells. Here, we introduce a ferroelectric-based heterojunction architecture that addresses this dual cha... |
41708600 | Structural defects in amyloid-β fibrils drive secondary nucleation. | Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer's and Parkinson's diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nuclea... |
41708507 | Fascinating single-cell red algae: models for evolution and adaptation. | The unicellular red algae, Cyanidiophyceae, that diverged early during Archaeplastida (algal and plant) evolution, occupy a variety of extreme habitats that are inhospitable for most other eukaryotes. With the use of modern genomics and genetics methods, Cyanidiophyceae show a remarkable taxonomic diversity, share hapl... |
41708497 | Intercropping legumes in the tea agroecosystem modulates tea quality and suppresses insect pest populations. | <h4>Background</h4>Tea is a crucial industrial beverage and cash crop that has been facing the dire effects of monoculture cropping (MCC), the accretion of pesticide residues and pest resurgence aggravated by climate change, and the disproportionate use of chemical inputs. Legumes are the most prominent cover crops tha... |
41708145 | Antigen-IL-2 CAR-enhancer drives CAR-T fate and stemness, enhancing antitumor efficacy across models independent of IL-2Rα. | <h4>Background</h4>Limited durability of clinical responses remains a major challenge in chimeric antigen receptor (CAR)-T therapy. CAR-enhancers (CAR-Es), which fuse tumor antigens to interleukin (IL)-2 muteins, provide a targeted strategy to enhance CAR-T persistence and function. It remained unclear whether CAR-Es a... |
41708062 | Secondary Coordination Sphere Effects in Macrocycle-Embedded Mononuclear Ru(bda) Water Oxidation Catalysts. | Integration of Ru(bda) [bda = (2,2'-bipyridine)-6,6'-dicarboxylate] water oxidation catalysts together with dibenzofuran, dibenzothiophene, or carbazole heterocycles within macrocycles <b>1</b>-<b>3</b> affords structures with different conformational preferences. The latter are dictated by noncovalent interactions of ... |
41707080 | DNA-Templated Silver Nanoclusters Demonstrate Potent Antimicrobial Activity Against the Clinically Relevant Pathogens, <i>Neisseria meningitidis</i> and <i>Streptococcus pneumoniae</i>. | Antimicrobial resistance is growing among the causative agents of bacterial meningitis, <i>Neisseria meningitidis</i> and <i>Streptococcus pneumoniae,</i> which trigger detrimental neuroinflammatory responses within the central nervous system. Here, we evaluated the antimicrobial potential of DNA-templated and stabiliz... |
41707060 | Artificial Spherical Chromatophore Mimicking LH2 and LH1-RC for Highly Efficient Photocatalytic Hydrogen Production with Turnover Number >667,000. | The supramolecular architecture of light-harvesting complex 2 (LH2) and light-harvesting complex 1-reaction center (LH1-RC) complexes underpins the near-unity quantum efficiency of photosynthesis in purple bacteria. Constructing artificial photosynthetic systems that structurally and functionally mimic these natural as... |
41707026 | Disclosing the True Critical Point of Fluids Confined in Nanopores. | Two methods for determining the pore critical point (PCP), i.e., the critical point of confined fluid, are currently available in the literature. The better-known method is based on the analysis of data obtained from adsorption isotherms, while the newer method analyzes the heat of capillary condensation data obtained ... |
41706894 | Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion. | Cancer cells migrate through regions of tissue confinement during metastasis, causing nuclear envelope (NE) rupture, which generates heritable DNA damage and disease aggression. We sought to determine if NE rupture was intrinsic to malignant transformation and seek a mechanistic cause. We found that metastatic cells fr... |
41706884 | Cryo-EM structure of locked spike glycoprotein from bat SARS-like coronavirus WIV1, molecular dynamics and biophysics across host range. | As made evident by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2 pandemics, the possibility of a SARS-like coronavirus (SL-CoV) emerging again in humankind after zoonotic spillover represents a significant global health threat. Given the role of spike (S) glycoprotein in mediating SL-CoV c... |
41706845 | Metal-organic framework/graphene nanoribbon/polyimide mixed-matrix membranes for high-temperature H<sub>2</sub>/N<sub>2</sub> separation. | We report the application of mixed-matrix membranes for high-temperature hydrogen separation. To enhance hydrogen selectivity, graphene nanoribbons (GNRs) were incorporated into ZIF-8 fillers, forming a physically confined structure conducive to hydrogen transport. The metal-organic framework (MOF)/GNR filler embedded ... |
41706838 | Morphology-adaptive Au-Ag nanowire elastronics for integrated FlexoSERS and bioelectrical sensing. | We introduce a morphology-adaptive Au-Ag nanowire elastronic platform that conforms to diverse geometries while enabling multimodal optical-electrical sensing. Using a facile yet versatile template-guided growth strategy, vertically aligned Au-Ag nanowire arrays are directly fabricated on 1D nano/microneedles, 2D elast... |
41706815 | Enhanced Light-Responsive Proton Conduction in MOF-808 via Cooperative Azobenzene and Ionic Liquid Functionalization. | Light-responsive proton conductors represent an attractive research direction owing to their potential in intelligent devices and responsive sensing applications. Herein, we present a cooperative functionalization strategy to construct an MOF-based light-regulated proton-conducting material, MOF-808-AZOA-IL, by integra... |
41706708 | Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium-chrysin target in breast carcinoma. | Cancer metabolic remodeling impacts the entire network of metabolic pathways, and strategies that target various points within this system could contribute to successfully abrogating cancer cell survival. Fatty acids (FAs) are essential to cancer cells because they support membrane biosynthesis during proliferation and... |
41706560 | <i>In Situ</i> Single-Crystal X-ray Diffraction Determinations of Cooperative Ammonia Capture in a Metal-Organic Framework. | Porous metal-organic frameworks (MOFs) are promising sorbents for ammonia (NH<sub>3</sub>) storage and capture; however, precisely defining the roles of active sites and establishing atomic-level insight into NH<sub>3</sub> binding domains remain challenging. Here, we report a robust zinc-allopurinol-imidazole framewor... |
41706164 | A regulatory circuit operated by KDELR1 and KDELR3 fine-tunes the composition of the early secretory pathway. | KDEL receptors (KDELRs) prevent the secretion of soluble chaperones and enzymes meant to reside in the endoplasmic reticulum. While a single KDELR exists in yeast (ERD2), three variants are present in mammals, displaying high sequence similarity. All three can prevent the secretion of KDEL-bearing clients. However, the... |
41706037 | Rational Construction of a Cu-Cu<sub>2</sub>O-CuHCF Heterojunction Interface for High-Performance Potassium-Ion Sensing. | The deployment of potassium ion (K<sup>+</sup>) sensors in demanding environments, such as marine resource utilization, energy storage systems, and industrial processes, is severely limited by the thermal instability of state-of-the-art sensing materials. Traditional ionophores like valinomycin and crown ethers irrever... |
41705957 | Achiral Guest-Modulated Circularly Polarized Luminescence of Chiral Macrocycles by Host-Guest Encapsulation. | Developing concise strategies to modulate circularly polarized luminescence (CPL) remains a significant challenge. In this study, we present a host-guest complexation approach to fine-tune the CPL properties of chiral macrocycles. The luminescence of the chiral macrocyclic hosts <i>R</i>/<i>S</i>-BINOL[2] can be modula... |
41705942 | Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex. | Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of model systems, including embryos of mammals, flies, frogs, and echinoderms, as well as a variety of cultured cells. While the cortical F-actin network is closely linke... |
41705852 | Differential targeting of human pyroptotic caspase-5 and caspase-4 by <i>Shigella</i> OspC2 and OspC3. | Pyroptosis is an inflammatory cell death pathway that is a key defense mechanism of intestinal epithelial cells. To successfully establish an infection, intracytosolic gram-negative pathogens must block this host response. Indeed, a <i>Shigella</i> effector OspC3, injected into cells by its type III secretion system, s... |
41705838 | Glycosylated NS3/NS3A protein of bluetongue virus facilitates efficient viral egress via lipid raft anchoring. | Bluetongue virus (BTV) is an economically important arbovirus of ruminants worldwide. The nonstructural glycoprotein NS3/NS3A contains a uniquely conserved N-linked glycosylation site at Asn<sub>150</sub>; yet, the functional consequences of this modification have remained unclear. Here, we characterize the Asn<sub>150... |
41705708 | Safe Stockpiling of the MTX-1 Primary Explosive in Alkali or Alkaline Earth Metal Complexes and Coordination Polymers. | The safe stockpiling of high-energy combustible and explosive materials is important for environmental and human population protection, particularly in mining and military areas. <b>MTX-1</b> (2-(tetrazol-5-yl-diazenyl)guanidine) is used in percussion primer compositions that react rapidly with the hydroxides of alkali... |
41705548 | Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer. | Pancreatic ductal adenocarcinoma (PDAC) features a dense desmoplastic stroma dominated by type I collagen, which forms a physical barrier that limits vascular perfusion and drug penetration, resulting in poor therapeutic outcomes. Here, we report gemcitabine-loaded collagenase-conjugated liposomes (GLCLs) that enzymati... |
41705482 | Synergistic Cyclodextrin-LiTFSI Coating on LLZTO toward High Ionic Conductivity PVA-Based Composite Electrolytes. | Poly(vinyl alcohol) (PVA)-ionic liquid-Li<sub>6.75</sub>La<sub>3</sub>Zr<sub>1.75</sub>Ta<sub>0.25</sub>O<sub>12</sub> (LLZTO) composite electrolyte (PIL) has drawn extensive research attention for lithium-ion batteries due to its high ionic conductivity. However, LLZTO tends to aggregate in PVA solution, which signifi... |
41705472 | Supramolecular net-suppressor drives tumor vascular-immune microenvironment remodeling with spatiotemporal synchronization for renal cancer therapy. | Advanced or metastatic renal cell carcinoma (RCC) responds poorly to current combination therapies, as anti-angiogenic agents and immune checkpoint inhibitors fail to act in a spatiotemporally synchronized manner. Consequently, their synergistic potential cannot be fully realized within the transient vascular normaliza... |
41705437 | 'Small' Technology, Big Power: Micropore Engineering for High-Performance Flow Battery Membranes. | Achieving carbon neutrality demands large-scale deployment of renewable energy, which in turn requires efficient, durable, and low-cost electrochemical energy storage systems. Redox flow batteries (RFBs) have emerged as a leading technology for grid-scale storage owing to their decoupled power and energy, long cycle li... |
41705293 | Ultra-Efficient Bamboo Microfiber Adsorbents for Formaldehyde Purification: Fabricated via In-Situ Growth of Dual Metal-Organic Frameworks. | An innovative strategy of heterointerface-driven formaldehyde capture was developed by dual metal organic framework (MOF) nanoarchitectures in-situ grown on bamboo microfibers (BMFs). The hierarchical BMF/MOF adsorbents were fabricated using steam-exploded BMFs as cores, followed by the sequential growth of indium-base... |
41704191 | Heptazine Based Photo-Programmable Azobenzene-Amino Acid Nanotubes for Augmented Drug Delivery and Chemo-Photodynamic Therapy in Glioma. | Heptazine or tri-s-triazine, is one of the oldest known nitrogen-containing heterocycles that kindled a new arena in biomedical research in the recent past due to their rich fascinating properties. Here, we report design and development of self-assembled nano biomaterials consisting of heptazine-derived π-conjugated az... |
41704185 | Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia. | The therapeutic landscape of acute myeloid leukaemia (AML) has evolved beyond the classic '7 + 3'/DA regimen, through the approval and incorporation of targeted treatments in both front-line and relapsed/refractory settings. Indeed, the use of selective BCL-2 antagonists (e.g. venetoclax) and FLT3 inhibitors (e.g. mido... |
41703632 | Synthesis and Li<sup>+</sup> conduction study of solid ionic liquids derived from Zwitterion modified metal-organic framework (MOF). | Construction of fast ion-conduction channels is of great significance for the performance breakthrough of Li<sup>+</sup> solid state electrolytes (LiSSE). It not only can significantly improve target ion transfer, but also enhance the Li<sup>+</sup> migration number. This study reports a new type of solid electrolyte o... |
41661193 | Design and self-assembly of an unconventional peptide-based dicephalic surfactant with an inverted architecture. | Surfactants with novel molecular architectures are increasingly being explored to achieve enhanced surface activity, stability, and biocompatibility. Among them, peptide-based surfactants have emerged as versatile alternatives to conventional systems due to their structural tunability and eco-friendly nature. In this s... |
41641690 | Tuning gas transport and separation in ZIF-8 membranes <i>via</i> point defects: insights from non-equilibrium molecular dynamics. | Understanding how intrinsic defects influence gas transport in metal-organic framework (MOF) membranes is crucial for the rational design of high-performance separation materials. In this study, non-equilibrium molecular dynamics (NEMD) simulations were employed to systematically investigate the permeation of four gase... |
41635171 | Tunable solvent-induced gelation of dipeptide-based gelators: exploring the role of solvent and acid concentration. | The tunability of the solvent-induced gelation mechanism using <i>tert</i>-butyl (<i>t</i>Bu) containing solvents and two <i>t</i>Bu-protected dipeptide precursor gelators (Boc-Phe-Phe-O<i>t</i>Bu - 1 and Boc-Leu-Phe-O<i>t</i>Bu - 2) is reported. Gelation behaviour, network morphology, material stability, and gelators'... |
41630596 | Electronic structure and excited-state analysis of covalently bridged diphenylhexatriene dimers: a route to design intramolecular singlet fission. | In the field of inter-molecular singlet fission (x-SF) materials, 1,6-diphenyl-1,3,5-hexatriene (DPH) molecule has already been proven to be a promising candidate both in experiment and theory. Moreover, the design of isomeric intra-molecular singlet fission (iSF) with DPH dimers reported in a recent study by Millingto... |
41627213 | Unveiling the influence of 3d transition metal (Sc-Zn) doping on quantum capacitance and surface charge storage in bare nano cages (Al<sub>12</sub>N<sub>12</sub>, Al<sub>12</sub>P<sub>12</sub>, B<sub>12</sub>N<sub>12</sub>, and B<sub>12</s... | Density functional theory is used to investigate the quantum capacitance (<i>C</i><sub>Q</sub>) and surface charge storage (<i>Q</i>) of bare (Al<sub>12</sub>N<sub>12</sub> (AN), Al<sub>12</sub>Pl<sub>12</sub> (AP), B<sub>12</sub>N<sub>12</sub> (BN), and B<sub>12</sub>P<sub>12</sub> (BP)) and 3d transition metal (TM) (... |
41610316 | Electrochemical synthesis of 2-substituted quinazolinones from primary benzylic C(sp<sup>3</sup>)-H bonds and 2-aminobenzamides. | An electrochemically promoted primary benzylic C(sp<sup>3</sup>)-H directed dehydrogenative cascade cyclization for the synthesis of quinazolinones was developed under undivided electrolytic conditions. In this protocol, neither external chemical oxidants nor transition-metal catalysts were needed, and a broad range of... |
41417029 | From lyotropic to thermotropic behavior: solvent-free liquid crystalline phases in polymer-surfactant-conjugated rod-shaped colloidal viruses. | Filamentous bacteriophages <i>fd</i> are viral particles, highly monodisperse in size, that have been widely used as a model colloidal system for studying the self-assembly of rod-shaped particles as well as a versatile template in nanoscience. In aqueous suspensions, <i>fd</i> viruses exhibit lyotropic behavior, formi... |
41859642 | Selenium nanoparticles: Eco-friendly synthesis, biological activities and biomedical applications - A comprehensive review. | The green synthesis of nanoparticles has emerged as a promising, eco-friendly, and cost-effective alternative to conventional chemical and physical methods, offering significant biomedical potential due to their biocompatibility, stability, and multifunctionality. This review provides a comprehensive overview of recent... |
41841127 | RNAi-mediated silencing of <i>Vitellogenin receptor</i> and <i>Ryanodine receptor</i>, key genes, by using carbon nanotubes for management of whitefly (<i>Bemisia tabaci</i>). | The whitefly <i>Bemisia tabaci</i> poses a significant threat to agriculture by transmitting various plant viruses, being globally invasive and polyphagous in nature. For the management of this pest, various cultural and chemical methods are employed, but challenges such as insecticide resistance and environmental impa... |
41832020 | Magnetically oriented chitin/C-Fe-MOF composite hydrogel with high toughness and conductivity for advanced soft electronics. | Hydrogels have gained increasing attention as flexible and conductive materials for soft electronics manufacturing. However, integrating skin-like multifunctionality into a gel that can be used under various conditions remains a significant challenge. Herein, we proposed a novel "one-stone-two-birds" strategy by utiliz... |
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