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41810075 | Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances. | Scar inhibition plays a crucial role in wound healing, particularly in the prevention of excessive scar formation during skin repair. While scar formation is a natural part of the healing process, improper scarring can lead to functional impairment, cosmetic defects, and psychological impacts. Therefore, understanding ... |
41809031 | Non-covalent interface engineering of multi-layer graphene cement composites using graphene oxide. | To address the critical demand for early strength in modern construction, this study proposes a novel MLGs/GO (multi-layer graphene/graphene oxide) nanocomposite system to synergistically enhance the early performance of cement mortar. Experimental results demonstrate that the optimized mixture (1.0% MLGs +0.025% GO) s... |
41796489 | Chemical reaction kinetics regulated dual-signal sensing system for discriminating EV-A71 and CV-A16. | A dual-signal system was developed to detect Enterovirus A71 (EV-A71, T<sub>EV</sub>) and Coxsackievirus A16 (CV-A16, T<sub>CV</sub>), leveraging the regulatory mechanisms of chemical reactions. MOF<sub>Fe</sub> acts as a catalyst, MOF<sub>Cr</sub> as a Fe<sup>2+</sup> reservoir. Specific DNA sequences (P<sub>EV</sub>,... |
41788293 | Nanoconfined Grain Boundaries Increase the Conductivity of Polycrystalline Molecular Crystals. | Soft-solid molecular crystals consist of crystalline grains and fluid grain boundaries (GBs) that enhance the grain binding and transport of Li<sup>+</sup> ions between the grains. The total ionic conductivity consists of ion migration in both the grains and GBs. To unravel these contributions in adiponitrile (Adpn):Li... |
41783823 | Analytical challenges and opportunities in the extraction, separation, and identification of food phospholipids. | Phospholipids (PLs) are minor but functionally important food lipids whose amphiphilic structure and strong interactions with the complex food matrix make their extraction and analysis challenging. This review summarizes a matrix-aware synthesis of current strategies for PLs extraction, purification, separation, and id... |
41783593 | Epigenetic remodeling during early embryonic development. | In mammals, the fusion of sperm and oocyte gives rise to a totipotent zygote, which undergoes a series of cleavage divisions and differentiation events. During this process, the embryo transitions from totipotency to pluripotency, accompanied by extensive epigenetic reprogramming. With continuous innovation of low-inpu... |
41783100 | Relationships between freeze tolerance and plant architecture in winter wheat during tillering stage. | Winter freezing injury is a critical factor limiting wheat(<i>Triticum aestivum</i> L.) productivity in northern China. Since freeze tolerance (FT) correlates with seedling growth traits, this study investigated the relationship between FT and plant architecture (PA) in winter wheat at the tillering stage. We evaluated... |
41782941 | Within-host adaptation mutations associated with persistent colonization of <i>Pseudomonas aeruginosa</i> in a silicosis patient. | <i>Pseudomonas aeruginosa</i> is a notorious opportunistic pathogen that causes life-threatening infections in immunocompromised individuals. In this study, we isolated two mucoid imipenem-resistant <i>P. aeruginosa</i> strains, SCPa14 and SCPa16, from a single silicosis patient. Whole-genome sequencing revealed that t... |
41782929 | Farnesol, the farnesol pathway, and the immune-gut-brain axis. | Experimental models and clinical evidence suggest that the gut and the central nervous system (CNS) interact in a multifactorial, bidirectional manner. A third player, the immune system, has recently been identified in these interactions, with research linking the gut microbiome to inflammatory conditions, including th... |
41782888 | Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma. | <h4>Background</h4>Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults, poses a formidable therapeutic challenge, due to its intrinsic radio- and chemoresistance and its ability to create a hostile, immunosuppressive tumor microenvironment (TME). Drug repurposing has emerged as a promising ... |
41782876 | CircNF1 promotes gastric cancer metastasis by stabilizing HMGA2 mRNA through IGF2BP1 interaction. | <h4>Introduction</h4>Gastric cancer (GC) is the fifth most common malignancy worldwide, with metastasis being the primary cause of mortality. Although circular RNAs (circRNAs) are implicated in GC pathogenesis, their specific roles in metastasis remain unclear. This study was designed to investigate the functional sign... |
41782678 | Glutamate transmission in the prelimbic cortex and nucleus accumbens shell is involved in ethanol reinforcement and drinking in rats. | <h4>Introduction</h4>Research has implicated mesocorticolimbic glutamate transmission in alcohol use. The current study focused on glutamate transmission within two key sub-regions, i.e., prelimbic (PL) cortex and nucleus accumbens (NAc) shell, in mediating ethanol reinforcement and drinking in rats.<h4>Methods</h4>Int... |
41767952 | Antibiotic resistance mediated by site-specific mutations in the multidrug efflux transporter CmeB of zoonotic pathogen <i>Campylobacter</i>. | The resistance‒nodulation‒division (RND) family of multidrug efflux transporters is widely distributed in Gram-negative bacteria. Although their roles in mediating antibiotic resistance have been well known, our understanding of how they are altered to augment bacterial adaptation to antibiotic selection remains at an ... |
41756359 | Characteristic of different thermal treatment-induced dough protein oxidation and its impact on human gut microbiota. | The thermal processing methods of flour products are diverse. This study aims to explore the effects of these methods (e.g., steaming, high-pressure, frying, baking, air frying, and microwave) on wheat dough protein oxidation and these oxidized proteins on human gut microbiota composition. We found that the different m... |
41754988 | Cyclodextrin Polymer Complexation Improves the Tolerability of Parenteral Oestradiol. | <b>Background</b>: Menopause is characterised by a decline in oestrogen levels, leading to physical and psychological symptoms that significantly affect quality of life. Current parenteral oestradiol ester therapies, while effective, are often associated with side effects due to their oil-based formulations, including ... |
41750932 | Biodegradable Films Targeting <i>Staphylococcus aureus</i>: Structure-Function Synergies and Interfacial Mechanisms. | <i>Staphylococcus aureus</i>, particularly its multidrug-resistant strains, poses a critical biological hazard throughout the global food supply chain, underscoring the need to transition from inert petroleum-based packaging to active, biodegradable alternatives. This review presents a comprehensive analysis of the str... |
41750636 | Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline. | The release of reactive oxygen species accompanying oxidative stress is one of the most significant damaging mechanisms during brain ischemia. Some aspects of the neuroprotective activity of the thyronamine T0AM synthetic analogue, 4-[4-(2-aminoethoxy)benzyl]aniline (ABA), were studied and discussed in two independent ... |
41743634 | Thermoresponsive artificial light-harvesting system with temperature-gated cascade energy transfer and photocatalysis. | Natural photosynthesis elegantly coordinates energy transfer, energy conversion, and environmental responsiveness within complex supramolecular frameworks. Replicating this multifunctionality in artificial systems remains a formidable challenge. In this work, we report a biomimetic light-harvesting system (LHS) constru... |
41746107 | Vaccination with an African Swine Fever Virus Multiepitope Protein Chitosan Nanoparticle-Based Subunit Vaccine Elicits Robust Immune Responses In Vivo. | <h4>Background/objectives</h4>African swine fever virus (ASFV), the causative agent of African swine fever (ASF), is a highly contagious virus affecting both domestic and feral pig populations with mortality rates approaching 100% within one week of infection. Currently, there are limited treatments or vaccines availab... |
41744799 | Comprehensive Review of Antiphospholipid Syndrome: Over Four Decades of Advances and Challenges. | Antiphospholipid syndrome (APS), first described in 1983, is a systemic autoimmune disorder characterized by recurrent arterial and venous thrombosis, pregnancy complications, and persistent antiphospholipid antibodies (aPL). Over four decades, significant advancements have been made in understanding APS pathogenesis, ... |
41744742 | Metal-Free Electrochemical Dopamine Sensing Using a g-C<sub>3</sub>N<sub>4</sub>/Polymethyl Thymol Blue Nanohybrid. | We report a highly sensitive and interference-free electrochemical sensor for dopamine (DA) detection in the presence of uric acid (UA) and ascorbic acid (AA), based on an in situ deposited graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) and polymethyl thymol blue (PMTB) nanohybrid modified screen-printed carbo... |
41737920 | Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis. | Terpenoids exhibit remarkable structural diversity, including highly complex ring-expanded or contracted carbocyclic skeletons. This review aims to explore intriguing examples of such ring-size alterations in all aspects of terpenoid synthesis. The current state-of-the-art regarding proposed biosynthetic pathways for t... |
41737638 | Spatiotemporally engineered microneedle for microenvironment remodeling propels mucosal regeneration after tracheal mucosal injury. | Remodeling the mucosal microenvironment is a pivotal step in severe tracheal mucosal injury (TMI), which may initiate a cascade of pathological events such as infection, inflammation, oxidative stress, and microvascular disruption. Current therapeutic strategies for TMI primarily focus on anti-infective or anti-inflamm... |
41737635 | Energetic metabolism-regulatory glycopeptide hydrogel accelerates pressure ulcer wound repair. | Pressure ulcers are a serious health-threatening condition, with wounds that are difficult to heal due to metabolic disorders, insufficient energy supply, and impaired tissue regeneration. Although current clinical treatments for chronic wounds show some reparative effects, ideal healing outcomes remain unattainable. I... |
41737637 | A continuous adhesion-enhanced osteogenic pathway in artificial scaffold drives cellular infiltration and condensed mineralization for rapid bone regeneration. | Enhancing the cellular infiltration and mineralization capacity of bone scaffolds can effectively address the challenges of bone nonunion and the prolonged osteogenic repair cycle, particularly in the treatment of critical-sized bone defects. Conventional bone scaffolds, whether composed of inorganic materials or fabri... |
41737136 | CAR-T Cell Therapy in Glioblastoma: Overcoming Immunological Barriers and Advancing Clinical Translation. | Chimeric antigen receptor (CAR) T-cell therapy has delivered unprecedented clinical benefit in hematological malignancies, yet its successful translation to solid tumors remains a major unmet clinical challenge. Glioblastoma (GBM), the most aggressive primary brain tumor, exemplifies the barriers confronting cellular i... |
41737047 | Engineered Exosomes: Advances in Therapeutic Applications for Otolaryngology-Head and Neck Diseases. | Given the intricate anatomy of otolaryngology-head and neck (OHNS) regions and the inherent limitations of conventional therapies, many OHNS diseases have suboptimal clinical outcomes. As natural intercellular mediators, exosomes have demonstrated unique application potential in OHNS treatment in recent years, thanks t... |
41737035 | Recent Progress in Selenium Nanomedicines for Ocular Diseases. | Vision impairment represents a significant and growing global socioeconomic burden. In the elderly population, cataracts, age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are the predominant causes of visual loss. Conventional ophthalmic drug therapies are limited by low bioavailability a... |
41737037 | Multiple Application Strategies of Carbon Dots in Cancer Treatment: Mechanisms, Progress and Challenges. | Cancer therapy has long been constrained by challenges such as high recurrence rates, high metastasis rates, and damage to normal tissues, and conventional therapeutic approaches struggle to achieve a precise balance between efficacy and safety. The innovation of nanotechnology has brought breakthroughs to this field. ... |
41737042 | Engineering Kidney-Targeted Drug Delivery Systems: Principles, Materials, and Emerging Strategies. | Kidney-targeted drug delivery is pivotal for treating renal diseases while minimizing systemic toxicity. To navigate the organ's complex physiological barriers, advanced nanomedicines employ integrated strategies. Our comprehensive narrative review provides a structured analysis of these strategies through a dual lens:... |
41737034 | Recent Advances in Nanozymes Toward Diabetic Foot Ulcers. | Diabetic foot ulcers (DFUs) are one of the most serious and intractable complications of diabetes, caused by oxidative stress due to hyperglycemia, chronic inflammation, and repeated infections. Conventional treatments such as insulin therapy do not improve the pathological wound microenvironment, resulting in slow hea... |
41734543 | A single CDs/Fe-MOF luminescent probe with dual-emission for the simultaneous detection of nitrite and copper (II) ions. | Nitrite (NO<sub>2</sub><sup>-</sup>) and copper (Cu<sup>2+</sup>) ions are widespread environmental pollutants that threaten both ecosystem integrity and human health, yet their simultaneous on-site detection remains challenging. To address this, we developed a dual-emissive luminescent probe by integrating 652 nm-emit... |
41724153 | Unlocking the potential of hop extracts through microencapsulation: Role of wall materials and drying technologies. | This study explores the effect of freeze-(FD) and spray-(SD) drying with maltodextrin, Arabic gum, and β-cyclodextrins (βCD), in producing microencapsulated hop extracts (MHEs) to use as food additives/ingredients with functional, techno-functional and stability properties. MHEs were characterized (HPLC-DAD analysis) f... |
41722205 | Ag aerogel/ZIF-8 nanocomposite as a sensitive and reproducible SERS platform for gaseous molecule detection. | Noble metals and metal-organic frameworks (MOFs) composite serve as prospective substrate for surface-enhanced Raman scattering (SERS) technology. Herein, an Ag aerogel/ZIF-8 nanocomposite was synthesized and exploited as an ultrasensitive SERS substrate. The as-designed Ag aerogel/ZIF-8 nanocomposite exhibited superio... |
41720059 | Theoretical insights into the application of petal Graphyne monolayer as a promising sensor for propylene oxide. | Detecting Propylene Oxide (PO) efficiently remains a key challenge in gas sensing technology. To address this, advanced computational analyses were performed to assess the sensing behavior of Petal-Graphyne (PLG). The adsorption energy, estimated at 31.54 kcal/mol, signifies a balanced interaction-strong enough to ensu... |
41720025 | Deep NO oxidation to nitrate with eliminated toxic NO<sub>2</sub> by-production via a microwave-constructed Fe-O-C photo-Fenton platform. | The deep oxidation of nitric oxide (NO) into nitrate (NO<sub>3</sub><sup>-</sup>) is crucial for air pollution control but remains challenging due to insufficient and unsynchronized reactive oxygen species (ROS) generation in conventional photocatalysts. Herein, we develop a microwave-assisted interfacial engineering s... |
41719930 | Bioelectricity generation and remission glyphosate stress for wheat by microbial fuel cell with a high-performance hollow Fe/Fe<sub>5</sub>C<sub>2</sub>-SNC@PNC cathode derived from mother-child "MOF on MOF". | Glyphosate residues pose significant ecological risks and microbial fuel cell (MFC) can degrade pesticides and generate bioelectricity but hindered by sluggish bioelectrons transfer in cathode. In this study, a mother-child "MOF-on-MOF" precursor (MOF: metal-organic framework) is designed via giving birth to ZnFe Pruss... |
41717429 | Integrated phytochemical, network pharmacology, and computational analysis to elucidate the anti-neurodegenerative mechanisms of <i>Parquetina nigrescens</i> and <i>Ficus capensis</i>. | <i>Ficus capensis</i> (FC) and <i>Parquetina nigrescens</i> (PN) are traditional African medicinal plants with reported neuropharmacological properties, yet their active compounds and mechanisms remain poorly characterized. This study employed an integrative experimental and computational strategy to compare their phyt... |
41713789 | An Evolutionary Distinct Nipah Virus N-Glycosylation Site Provides Stability for Receptor Engagement. | Nipah virus is a deadly paramyxovirus with 40 to 75% mortality and >750 cases since 1998. Currently there are no clinically approved vaccines or therapeutics to treat infection. Nipah is an enveloped virus with two surface glycoproteins, the trimeric fusion glycoprotein (F), and the tetrameric attachment glycoprotein (... |
41713733 | Enhanced lateral flow immunoassay for point-of-care monitoring of sulfamethazine residues based on antibody labeled with Au/Ir@Cu/Zn-MOF signal amplification. | <h4>Introduction</h4>Sulfamethazine (SM2) antibiotic residues in food pose a significant risk to human health, including pathogenic bacterial resistance, allergic reactions, and carcinogenicity. Current lateral flow immunoassay (LFIA) typically employing colloidal gold (AuNP) as a signal reporter exhibits unsatisfactor... |
41713735 | An antibacterial microneedle with chemodynamic therapy triggered by microwave thermal effect for diabetic infected wound healing. | <h4>Introduction</h4>Microwave-assisted therapy possesses a good prospect of clinical application in bacterial infections treatment owing to the excellent tissue penetration. However, the weak energy of microwave limits the catalytic performance of sensitizers to generate enough reactive oxygen species to kill bacteria... |
41713337 | Enhancing antioxidant activity and bioaccessibility of lycopene and quercetin via synergistic co-delivery in gellan gum-stabilized oil-in-water emulsion. | Gellan gum (GG)-stabilized emulsion system was developed for the synergistic co-delivery of quercetin (QU) and lycopene (LYC). GG-QU complex prepared through Ca<sup>2+</sup> chelation was used as the aqueous phase to form an oil-in-water emulsion for encapsulating LYC. Fourier transform infrared spectroscopy and Nuclea... |
41713346 | Rationally constructed nanoprobe based on the molecular docking strategy for rapid hypochlorous acid detection in foods and biosystems. | Hypochlorous acid (HClO) is not only often used as an effective preservative in the food industry, but also is an important reactive oxygen species in organisms. Herein, a series of Near-infrared (NIR) small-molecule HClO fluorescent probes based on dicyanoisophorone fluorophore were constructed by reasonable design, a... |
41713121 | High-frequency sonochemical conversion of hydrophobic polyphenols into functional nanoparticles for bioengineering. | Polyphenols are natural compounds with diverse biological activities; however, their practical applications are often limited by poor solubility and chemical instability. In this study, a high-frequency ultrasound-assisted approach is developed for the preparation of polyphenol nanoparticles (NPs), producing well-dispe... |
41710869 | Re-evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares. | The present opinion deals with the re-evaluation of sucralose (E 955) as food additive and with the safety of a proposed extension of use in food category (FC) 7.2 'Fine bakery wares'. Based on the available data, no safety concerns arose for genotoxicity of sucralose (E 955) and its impurities and degradation products... |
41710870 | A novel molecularly engineered deep eutectic surfactant from a Gemini ionic liquid and methylurea for EOR utilization: a joint experimental and computational study. | It is well established that surfactant-assisted enhanced oil recovery (EOR) offers significant advantages for improving oil production efficiency. In this study, a surface-active deep eutectic surfactant (DESU) was synthesized from a Gemini surface active ionic liquid (GSAIL) and methylurea in a molar ratio of 3 : 2, a... |
41710871 | Introduction to carbon nanoarchitectonics for advanced applications in energy, environment and bio. | This editorial summarizes the history and outlines the importance of carbon nanoarchitectonics together with recent examples of energy, the environment, and bio-related applications. |
41710777 | Selecting Hydrogel Films Composed of Carboxymethyl Cellulose and Microcrystalline Cellulose From OPEFB With Citric Acid as a Green Crosslinker for Fruit Wrapping. | Cellulose-based hydrogel films are promising alternatives to plastic for wrapping. Hydrogel films based on carboxymethyl cellulose (CMC) and microcrystalline cellulose (MCC) must exhibit high mechanical strength and be capable of absorbing moisture. Crosslinking increases the absorption capacity and mechanical strength... |
41710494 | Pulmonary drug delivery of quercetin through scalable PEGylated mixed micelles of Gelucire® and Tetronic®. | Many potent anticancer agents suffer from poor water solubility, limiting their industrial translation into effective formulations. Although single micellar systems have been explored to address this issue, they often exhibit low stability and encapsulation efficiency. To overcome these limitations, this study develope... |
41710491 | From structure to function: a one-dimensional palladium(ii) hybrid for real-sample hydroquinone detection. | A novel one-dimensional (1D) organic-inorganic hybrid compound, (C<sub>4</sub>H<sub>7</sub>N<sub>2</sub>)[PdCl<sub>3</sub>(H<sub>2</sub>O)], was synthesized through the reaction of palladium(ii) chloride with 2-methylimidazole in an aqueous acidic medium. The structure was elucidated through single-crystal X-ray diffra... |
41710490 | Microwave-assisted N,S doped carbon quantum dots as fluorescent nanoprobes for vibegron determination: face-centered design optimization, validation, and green chemistry assessment. | A novel, sensitive, and environmentally sustainable spectrofluorimetric method was developed for vibegron quantification in pharmaceutical formulations and biological matrices using nitrogen and sulfur co-doped carbon quantum dots (N,S CQDs) as fluorescent nanoprobes. The N,S-CQDs were synthesized <i>via</i> rapid micr... |
41710488 | Influence of nickel doping on the moisture adsorption properties of magnesium aluminate spinel: thermodynamic and kinetic analysis. | Magnesium aluminate spinel (MAS) has been widely investigated due to its exceptional properties, which include a high melting point, thermal stability, chemical inertness, abundant vacant sites, substantial porosity, and strong mechanical resilience. The hygroscopic nature of MAS continues to be a major drawback that l... |
41710206 | Protein-encapsulated fluorogenic probes for the selective detection of endogenous O-GlcNAcase (OGA). | Ever-increasing evidence confirms the role of O-GlcNAcase (OGA) in mediating cell growth and development as well as pathology and underscores the importance of developing sensitive and selective chemical tools for the study of OGA biology. Here, based on our previously developed protein-encapsulation strategy, we desig... |
41710200 | Glutathione-activatable synthetic channel for hopping-mediated anion transport. | Controlled transport of ions across the cellular membrane is an essential process. While nature employs stimuli-gated transmembrane proteins to facilitate the appropriate transport of essential ions or molecules across cellular membranes, the endeavor to create a stimuli-controlled synthetic analogue presents considera... |
41709880 | Harnessing Bacterial Lipid Coatings on Gold Nanoparticles for Enhanced Cell Adhesion Applications. | Antimicrobial resistance (AMR) is a global health challenge responsible for millions of deaths annually. Hence, there is an urgent need for improved strategies to combat AMR. Nanoparticle (NP)-based drug delivery has shown promise for enhancing the efficacy of conventional antibiotic treatments. Moreover, lipid functio... |
41708406 | 18-Crown-6 ether increases molecular weight of poly(3-hydroxybutyrate) synthesized in Escherichia coli. | Molecular weight of polyhydroxyalkanoate (PHA) is a critical factor governing their physical properties, particularly mechanical strength. It is empirically known that molecular weight of PHA varies depending on factors such as the microbial host and the type of PHA synthase (PhaC). However, methods for controlling the... |
41707414 | Beyond sieving: A review on active ion recognition via interfacial nanoarchitecture for selective lithium recovery. | To address the impending lithium supply crisis, membrane-based extraction from salt-lake brines has emerged as a pivotal area of research in the field of critical metals. Traditional polymeric membranes demonstrate limited Li<sup>+</sup>/Mg<sup>2+</sup> selectivity and suffer from rapid degradation in highly saline, al... |
41703994 | Anion- and Conjugated Building Block-Driven Construction of Handcuffs and Cages, Featuring <i>In Situ</i> Topological Transformation from Handcuff to Double-Z Cage. | A flexible tetradentate ligand, <b>L</b>,1,2,4,5-tetrakis((pyridin-4-ylthio)methyl)benzene, was designed to precisely construct topologically distinct handcuff-shaped molecules <b>1</b>,<b>2</b> and Double-Z cage <b>1</b> through coordination-driven self-assembly with building blocks (<b>B1</b>-<b>B3</b>). In particula... |
41703944 | Engineering MOF-Assembled Nanochannels for Enantioselective Detection and Separation of Chiral Drugs. | Developing highly efficient and robust membrane systems for the selective identification and screening of chiral drugs is an exceptionally challenging task. Herein, we report that functional metal-organic framework (MOF)-packed nanochannels can serve as an excellent chiral recognition platform for enantioselective dete... |
41703909 | (N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters. | Following previous observations that <i>N</i><sup>6</sup>-elongated (N)-methanocarba adenosine derivatives modulate efflux pump activity associated with multidrug resistance (MDR) in tumors, we synthesized and characterized 34 nucleoside analogues. Effects on ATPase activity of both ABCG2 and P-glycoprotein identified ... |
41703783 | Beyond Hydrogen Bonding: π···π Stacking Directed Self-Assembly of Carboxylic Acid Clusters in the Gas Phase. | Carboxylic acids critically influence atmospheric chemistry by modulating acidity, new particle formation, and aerosol growth. The hydrogen-bonding capability of the -COOH group drives the assembly of structurally diverse gas-phase clusters with atmospheric species. Despite their importance, experimental data on larger... |
41703764 | Benefits of Categorizing Noncovalent Bonds Based on Hydrogen, Halogen, Chalcogen, and Pnictogen Bonds. | Recent IUPAC recommendations define the halogen bond, the chalcogen bond, and the pnictogen bond as the interactions between nucleophilic sites and electrophilic elements of groups 17, 16, and 15 of the periodic table. In a recent paper Robin Taylor states that, the use of these three terms should be "deprecated" and h... |
41703762 | Macromolecular Condensates as Tunable Scaffolds for Bio-Inspired Silica Hybrids. | Silica-based materials are of immense functionality as their production is versatile and can accommodate a wide range of properties. Nevertheless, no synthetic system can reproduce the ability of organisms to precipitate dense silica under ambient conditions and from dilute soluble precursors, leaving a substantial gap... |
41703738 | Supramolecular Assembly of a Heavy-Atom-Free Highly Efficient Self-Deliverable Photosensitizer for Activable Photodynamic Therapy. | This article introduces a heavy-atom-free, acceptor-donor-acceptor conjugated organic photosensitizer (ADA-S), exhibiting an exceptional singlet oxygen (<sup>1</sup>O<sub>2</sub>) quantum yield (Φ∆) ∼1. The ADA-S structure integrates two thionated naphthalene-monoamide acceptors with a central thiophene donor moiety. T... |
41703728 | Label-Free Fluorescence-Based Enzyme Assays Using Supramolecular Host-Guest Approaches. | Monitoring enzymatic reactions is crucial in enzymology, drug metabolism, and bioengineering. Supramolecular tandem enzyme assays (STA), based on indicator displacement assays, leverage the differential binding affinities of supramolecular hosts for enzymatic substrates and products. STA enables label-free, real-time, ... |
41703712 | Sequence-Modulated Active Tripeptide Condensates for Tandem Catalysis. | Biomolecular condensates formed via liquid-liquid phase separation function as dynamic organelles that are vital to regulating cellular activities. Peptide-based coacervates have emerged as appealing candidates to resemble key properties of biomolecular condensates. However, their application as adaptive organelles has... |
41703661 | Visible light active Bi<sub>2</sub>S<sub>3</sub>/ZIF-8 MOF composite for concurrent doxycycline degradation and antibacterial action. | In order to address ecological and significant health concerns, this study investigates a unique water treatment solution using photocatalysis and antibacterial applications. A ZIF-8 based nanocomposite is synthesized via solvothermal formation by incorporating Bi<sub>2</sub>S<sub>3</sub> into ZIF-8, followed by photod... |
41703644 | Divergent prognostic roles and risk determinants of myocardial injury in SFTS and HFRS. | <h4>Background</h4>This study explored the role of myocardial injury in the prognostic assessment of severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) patients, and analyzed its risk factors.<h4>Methods</h4>A retrospective study included 188 SFTS and 101 HFRS patients (... |
41703368 | Comparative study of thiolated and alkenylated functionalized β-CDs as highly mucopenetrating and mucoadhesive drug delivery systems. | Within this study, thiolated and alkenylated β-cyclodextrins were developed as novel mucoadhesive excipients capable of interacting with mucosal surfaces and prolonging the residence time of incorporated drugs at absorption sites, thereby potentially enhancing their bioavailability. For this purpose, cysteine-, cysteam... |
41703341 | Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor. | The outer membrane of Gram-negative bacteria is an asymmetric bilayer in which lipopolysaccharide (LPS), the principal component of the outer leaflet, promotes tight packing and ordering of the membrane components that are essential for the barrier and load-bearing functions of this membrane. Lipopolysaccharide mobilit... |
41703287 | Immunogenicity assessment and epitope mapping of the ASFV proteome by profiling serum antibodies with ASFV antigen phage libraries. | The continued spread and regular outbreaks of African swine fever (ASF) have severely threatened the pig-related industries, causing economic losses. African swine fever virus (ASFV) encoded more than 150 different proteins, but the biological characteristics of the majority of these proteins remain unknown. In this st... |
41703233 | Chrysanthemum classification via color space fusion transformer. | Chrysanthemum is a traditional Chinese medicinal herb that contains significant medicinal and economic value. However, the medicinal and economic value of chrysanthemum differs depending on its regions and types. Therefore, it is valuable to classify chrysanthemum accurately. Traditional classification methods are cost... |
41703070 | Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope. | Granulomatosis with polyangiitis is a life-threatening systemic vasculitis, characterised by anti-neutrophil cytoplasmic autoantibodies (ANCA) most commonly against proteinase 3 (PR3), a protease expressed intracellularly and on the surface of neutrophils. Most cell surface PR3 is bound to the receptor CD177; however, ... |
41703071 | Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast. | Gim3 is an evolutionarily conserved component of the prefoldin chaperone complex, involved in protein folding. We previously found that GIM3 genetically interacts with many de novo mutations in Saccharomyces cerevisiae. Removing GIM3 from mutagenized S. cerevisiae cells significantly affected the fitness effect of muta... |
41702958 | QLSA-MOEAD integration for precision task scheduling in heterogeneous computing environments. | Heterogeneous computing infrastructures integrating CPUs, GPUs, and FPGAs present critical challenges in efficient task scheduling due to hardware diversity, complex task dependencies, and conflicting optimization objectives. This work formulates workflow scheduling as a multi-objective optimization problem that minimi... |
41702702 | Design and Synthesis of Chiral Macrocycles Consisting of Azobenzene Units That Undergo Asymmetric Photochemical and Thermal Isomerization. | It is well known that azobenzene undergoes reversible isomerization between (<i>E</i>)- and (<i>Z</i>)-forms upon irradiation with ultraviolet (UV) and visible light. This phenomenon has been extensively explored for its potential utility in photoresponsive systems and molecular machines. However, there are only a few ... |
41702590 | Anisosmotic Modulation of Mutant Huntingtin Aggregation vis-a-vis HSP70 Induction─Implications for Aging, Hypo-Hydration, and Neurodegeneration. | Suboptimal cell hydration is a significant risk factor for age-related deterioration and disease vulnerability. Herein, we use a Huntington disease cell model to evaluate osmolarity-dependent modulation of (1) aggregation of polyQ-expanded mutant Huntingtin-EGFP reporter protein as a readout for structurally dynamic di... |
41701904 | Cholesterol Mediates Gp41 Linear Aggregation and Enhanced Membrane Curvature during HIV-1 Infection. | The envelope glycoprotein gp41 of HIV-1 plays a critical role in mediating viral entry through membrane fusion. Although the viral membrane is highly enriched in cholesterol, which is essential for infectivity, the molecular mechanisms by which cholesterol regulates gp41 behavior and membrane remodeling remain poorly u... |
41701869 | A Smartphone Sensing Platform Based on Multilanthanide Metal-Organic Framework Sensors for Portable Visual Quantitative Detection of Antibiotic Residues. | Both enrofloxacin and tetracycline hydrochloride are widely used antibiotics, and the harm caused by their abuse affects the ecological balance and human health. In this study, La-MOFs based on polycarboxylate ligands were prepared and three functionalized multilanthanide metal-organic framework sensors were obtained b... |
41701840 | Ion transport through reconfigurable nanoparticle-surfactant stabilized droplet interface bilayers. | Despite their adaptability and mechanical stability, Pickering emulsions based on the interfacial assembly of colloidal particles have not found use in iontronics, since the dense interfacial packing of micron-sized particles precludes functional connectivity between two droplets. Here, we introduce a chemically reconf... |
41701783 | The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response. | Porcine astrovirus (PAstV) is globally prevalent in swine and is associated with diarrhea and encephalitis in piglets, posing a threat to porcine health. However, its pathogenic mechanisms remain poorly understood. This study used the PAstV1-GX1 strain to infect PK-15 cells, revealing that the virus induces significant... |
41701720 | Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain. | Rift Valley fever virus (RVFV) poses a continued threat to human health and animal husbandry. Two neutralizing and protective human monoclonal antibodies (mAbs), RVFV-268 and RVFV-379, exhibit similar affinities and epitope footprints on the Gn glycoprotein component of the RVFV Gn-Gc capsomeric lattice. Here, we defin... |
41701645 | Thermodynamic Data Remain a Hot Tip for Decoding Binding Affinity and Water Impact on Protein-Ligand Complex Formation to Assist Lead Optimization. | Optimization of screening hits from lead-finding campaigns into promising lead candidates can be supported by factorizing thermodynamic binding profiles into enthalpic and entropic contributions. Given that data are recorded for large multicomponent systems, typically affected by substantial enthalpy/entropy compensati... |
41701504 | Commutative Algebra Modeling in Materials Science - A Case Study on Metal-Organic Frameworks (MOFs). | Metal-organic frameworks (MOFs) are a class of important crystalline and highly porous materials whose hierarchical geometry and chemistry hinder interpretable predictions in materials properties. Commutative algebra is a branch of abstract algebra that has been rarely applied in data and material sciences. We introduc... |
41701425 | Adhesion Reinforcement of Electrode-Electrolyte Interface in Flexible Electrochemical Energy Storage Devices. | Wearable and deformable electronics are becoming increasingly essential components of modern healthcare and daily life. To power such devices, flexible electrochemical energy storage (FEES) plays a critical role. The practical performance of FEES is dominated by charge and mass transfer at the electrode-electrolyte int... |
41701294 | Probing Electrode-Electrolyte Synergy and Bottleneck Breakthrough of Zinc-Ion Capacitors from Two Key Configurations. | In response to the demanding requirements of next-generation energy storage systems for high-energy density, high-power density, and ultra-long-cycle life, the academic community has continued to focus on coupled devices that combine battery-level energy and capacitor-level power characteristics. Zinc-ion capacitors (Z... |
41701185 | Macrocyclic Covalent Encapsulation of a Multi-Resonant Emitter: Understanding and Controlling Interactions in Highly Efficient Deep-Blue OLEDs. | Multi-resonant thermally activated delayed fluorescence (MR-TADF) emitters have emerged as popular candidates for the development of blue organic light-emitting diodes (OLEDs), offering narrowband emission, high photoluminescence quantum yields (PLQYs), and the ability to upconvert dark triplet states to bright singlet... |
41701144 | Ethanol-Assisted Alkanethiol Self-Assembled Monolayer Disruption by Mobile Siloxane Oligomers for Precise Galvanic Replacement Positioning. | Siloxane oligomers with low molecular weights often exist in elastomeric polymers, e.g., polydimethylsiloxane, and can be troublesome chemical species when utilizing polymers due to their hard-to-control behavior and unpredictable mobility. For instance, the presence of these species can contaminate surfaces and affect... |
41701102 | Constructing <i>Z</i>-Scheme Ni-MOF-74/CoAl-Layered Double Hydroxide Heterojunctions for Enhanced Photocatalytic CO<sub>2</sub> Reduction. | Constructing <i>Z</i>-scheme heterojunctions is crucial for improving the charge localization on the surface of photocatalysts and enhancing photocatalytic reduction performance. Herein, this research proposes a heterostructure construction strategy that utilizes a Nickel-based metal organic framework with MOF-74 topol... |
41700979 | Selective Gas-Phase Ethylene Dimerization to 1-Butene in a Scalable Metal-Organic Framework. | High-purity 1-butene is a crucial feedstock for the plastics industry and is currently produced by homogeneously catalyzed ethylene dimerization. Processes of this scale can benefit from heterogeneous catalysis, especially if reactants are delivered in the gas phase, to allow product recovery in flow. However, catalyst... |
41700904 | AGPAT1 is a novel Chikungunya virus receptor on human cells. | Chikungunya virus (CHIKV) is a medically important alphavirus whose host receptor is not fully understood. We identified AGPAT1 from the human Huh7 cell plasma membrane binding with CHIKV particles <i>in vitro</i>. The CHIKV binding with AGPAT1 was demonstrated on Huh7 cell plasma membrane by confocal microscopy. The A... |
41700902 | Construction of Peptide Amphiphile-Coated Coacervates with Selective Permeability. | The combination of membranes with coacervates has been regarded as an effective approach to stabilize coacervates and modify their surface properties. Here, we achieved the construction of a functional coacervate system by localizing nanovesicles assembled by elastin-like peptide-block-collagen-like peptides (ELP-CLPs)... |
41700891 | Gradual Modification of Ferritin 4-Fold Pore Promotes Cage Instability, Fe<sup>2+</sup> Exit, and Iron-Induced Protein Precipitation. | Ferritins are symmetrical, hollow nanocaged iron storage proteins, which sequester and concentrate iron as a hydrated ferric oxyhydroxide (ferrihydrite) biomineral. Spontaneous self-assembly of 24 subunits in eukaryotic ferritins leads to the formation of symmetrical pores, i.e., eight hydrophilic 3-fold pores and six ... |
41700837 | Anion-Guided Controlled Molecular Growth of Multi-Component Giant Mo Wheel Family for Enhanced Oxidation Catalysis. | Understanding the self-assembly of multicomponent giant polyoxometalates and their subsequent controlled molecular growth is crucial for addressing the challenges of building multicomponent structural motifs and elucidating structure-property relationships in complex cluster chemistry, yet it presents a significant cha... |
41700799 | Performance of U.S.- FRAX TM by Race and Ethnicity for Short-term Hip and Major Osteoporotic Fracture Prediction in U.S. Women with Rheumatoid Arthritis. | Women with rheumatoid arthritis (RA) face elevated fracture risk, yet performance of the U.S.-FRAX™ across racial and ethnic groups in RA remains understudied. In this retrospective cohort study, we examined 14,533 women aged ≥65 years with RA from the U.S. national Rheumatology Informatics System for Effectiveness reg... |
41700640 | Tailoring Coordination and Pore Structure of MOF-Derived Co Single-Atom Catalysts Anchored on Graphene for Rechargeable Zinc-Air Batteries. | Achieving high-performance single-atom catalysts (SACs) for rechargeable Zn-air batteries (ZABs) requires simultaneous optimization of pore structure and coordination environment. However, MOF-derived SACs typically feature micropore-dominated carbon frameworks and planar coordination symmetry, restricting oxygen diffu... |
41700630 | High-Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting. | Mitochondrial targeting is a powerful strategy for cancer precision therapy. This study presents a subcellular DNA barcoding system for high-throughput in vivo screening of mitochondrial-targeting gold nanoparticles (NPs). After validating the robustness of the barcode system with six PEG/TPP‑modified NPs in vitro, the... |
41700626 | Sequential Optimization of Multivariate Metal-Organic Framework Based Biocatalysis. | Efficient biocascades require integrated optimization of both biocatalysts and reaction conditions. In the present study, we employ a Latin hypercube sampling-coupled Bayesian optimization (LHS-BO) workflow to sequentially optimizes multivariate Zr-based E-MOF (E-MOF = enzyme@metal-organic framework biocomposite) desig... |
41700606 | Size-Transformable Supramolecular Nanoprodrugs Enable Redox Imbalance Amplification and Cholesterol Modulation to Boost Multidimensional Tumor Immunotherapy. | Low immunogenicity and highly immunosuppressive tumor microenvironment (TME) present major challenges in immunotherapy, as they restrict T lymphocyte infiltration and activation. Although ferroptosis induction has emerged as a promising approach for enhancing tumor immunogenicity and promoting T cell recruitment, its e... |
41700552 | In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy. | The synthesis of non-natural polymers inside living systems has become an effective approach for controlling cellular functions and behaviors. However, in situ synthesis of crystalline polymers, such as covalent organic frameworks (COFs), inside cells using dynamic covalent chemistry faces challenges in aqueous environ... |
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