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41700543 | Development of a Novel Polyleucine-Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus. | Mixture-based vaccine formulations offer distinct advantages by eliminating the need for chemical conjugation or complex encapsulations, thereby streamlining preparation, enhancing versatility, and reducing cost and production time. In this study, we report the design of a novel polypeptide-based self-assembling adjuva... |
41700536 | Self-assembled Helical Tetramer Stack of Terrylene Bisimide in Solution and Crystalline State. | A terrylene bisimide (TBI) derivative 1 bearing bulky meta-terphenyl imide substituents is shown to self-assemble into helical [1<sub>4</sub>] tetramer stacks in solution. Driven by strong dispersion and electrostatic forces, a direct transition from monomers into defined tetramers is already observed in the micromolar... |
41700421 | The Strand Cycling Amplification Nanosensor Platform: A Bioinformatic-Guided Biosensor for Single-Nucleotide-Specific Detection of <i><i>Pseudomonas aeruginosa</i></i>. | <i><i>Pseudomonas aeruginosa</i></i> is a high-priority antibiotic-resistant pathogen that requires rapid and specific diagnostic methods. We present an electrochemical biosensor platform named SCAN (Strand Cycling Amplification Nanosensor) for the highly accurate and efficient detection of <i><i>P. aeruginosa</i></i>.... |
41700426 | Homochiral Porous Organic Imine Supramolecular Nanotube as a Stationary Phase for Highly Efficient Separation of Isomers and Racemates in Gas Chromatography. | Porous organic imine supramolecular nanotubes (ISNTs), as a subclass of synthetic organic molecular nanotubes with nanotubular structures, permanent and confined cavities, and defined transport channels, have recently attracted considerable interest in diverse applications. In this study, a homochiral porous organic IS... |
41700341 | Reining in Multidrug Resistance Protein 1 via Binding Its Flexible Interdomain Linker with Sequence-Selective Peptide-Binding Nanoparticles. | Overexpressed ATP-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1) encoded by ABCC1, are responsible for multidrug resistance in anticancer treatment due to their abilities to prevent drugs from reaching their lethal intracellular concentrations. Similar overexpression of drug efflux p... |
41700127 | Electrocatalytic C─N Coupling in Aqueous Solutions for High-Value Product Synthesis. | Organic nitrogen-containing compounds, such as urea, amines, amides, and amino acids, play a crucial role in global biogeochemical cycles and industrial systems. Electrocatalytic C─N coupling, enabling reactions under mild conditions (room temperature/pressure) and utilizing a range of feedstocks (CO<sub>2</sub>, CO, N... |
41700102 | Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease. | Ischemic heart disease (IHD) remains the foremost cause of mortality worldwide, characterized by extensive myocardial injury following infarction with limited regenerative capacity of the adult mammalian heart. RNA interference (RNAi) nanotechnology is revolutionizing cardiac therapy by leveraging the sequence-oriented... |
41700031 | High-Entropy Hydroxyl Carbonate With Zn, Co, Ni, Cu, and In as an Efficient Catalyst for Benzyl Alcohol Upgrading. | Electrocatalytic hydrogen production is pivotal for advancing the transition to green energy. However, its widespread application is hindered by the limited efficiency of electrocatalysts and the sluggish kinetics of the anodic oxygen evolution reaction (OER). Developing high-performance, durable, and cost-effective el... |
41699310 | The double-edged sword of ion channel-targeting pesticides: a paradigm shift from health risks to precision intervention. | Amidst the dual challenges of global food security and ecological security, the development of highly effective and low-risk green pesticides has become a critical pathway for promoting sustainable agricultural development. This review systematically summarizes the dual characteristics of novel pesticides targeting ion... |
41698929 | Strategies to control the geometry and symmetry around lanthanide centres for tailored luminescence and magnetism. | The luminescent and magnetic properties of trivalent lanthanides (Ln<sup>3+</sup>) are indispensable for many emerging technologies, but exacting fine control over these properties requires an understanding of how to purposefully engineer the coordination geometry and site symmetry of Ln<sup>3+</sup> centres. Here, we ... |
41698883 | Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry. | Enveloped virus invasion relies on spike glycoprotein-mediated membrane fusion. Cholesterol that serves crucial roles in modulating protein conformations and membrane properties, plays an essential role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry. However, the precise regulatory mecha... |
41649488 | Multivariate MOF-303/MIL-160 balancing the trade-off between capacity and selectivity in CO<sub>2</sub>/CH<sub>4</sub> separation. | Porous adsorbents with high capacity and selectivity are recognized as promising alternatives for energy-efficient gas separation, but the inherent trade-off between the two metrics hinders their industrial application. Herein, we synthesize a multivariate Al-based metal-organic framework (MOF), namely MOF-303/MIL-160,... |
41622676 | Condensates and cell states: A new paradigm for understanding tumor biology. | Traditionally, cells have been classified by their type. Identifying cell types was deemed vital for understanding their biological processes. More recently, cell-type classification has been recognized as insufficient. Cells have many transient states that depend on their spatial environment. Thus, the current cell-st... |
41612889 | Two-dimensional metal-organic framework/graphene oxide composites as proton conductors: chemical grafting <i>vs</i>. physical blending. | A water-stable two-dimensional (2D) zirconium-based metal-organic framework (MOF), ZrBTB (BTB = 1,3,5-tri(4-carboxyphenyl)benzene), serves as a porous platform to integrate with graphene oxide (GO) in order to achieve ultrahigh proton conductivity (<i>σ</i>). Two synthetic methods, chemical grafting and physical blendi... |
41603882 | A dual-mode subphthalocyanine-functionalized calix[4]arene based turn-off-on fluorescent sensor for selective detection of tebuconazole pesticide in food and water samples. | In this study, a novel subphthalocyanine-substituted calix[4]arene (Calix-Sub) fluorophore was designed and synthesized. Its structure was characterized by FT-IR, MALDI-TOF, <sup>1</sup>H-NMR, and elemental analyses. Calixarenes are promising sensors due to their rigid structures, complexation abilities, and selectivit... |
41603757 | A step-by-step structural transformation of the Ru-Ru bonding unit from a paddle-wheel to edge-sharing bi-octahedra configuration. | The structural transformation of the metal-metal bonding dimer induced by external stimuli is of scientific significance in terms of both the synthesis and reactivity of M-M compounds. This study reported the transformation stimulated by Et<sub>3</sub>N from paddle-wheel Ru<sub>2</sub>(CH<sub>3</sub>CO<sub>2</sub>)<sub... |
41582851 | Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery <i>via</i> dynamic thiol-disulfide exchange. | Effective delivery of small interfering RNA (siRNA) to the cytosol continues to pose a significant challenge in RNA interference (RNAi)-driven precision cancer therapy. In this study, we engineered glutathione (GSH)-responsive bola-amphiphilic peptide dendrimers (bola DS-C<sub><i>n</i></sub>-K<sub>4</sub>) for tumor-sp... |
41574663 | Bionic ion skin multimodal system for advanced epidermal electronics. | Bionic ion skin technology embodies a pivotal advancement in epidermal electronics, moving beyond elementary sensing functions to emulate the sophisticated multimodal perception of natural skin. Current research landscapes reveal a conspicuous disconnect: although ionic conduction mechanisms and general hydrogel proper... |
41560676 | Programming self-powered motion <i>via</i> "host-guest" recognition. | Autonomous motion is a defining characteristic of living systems, emerging from the conversion of chemical energy into mechanical work through dynamic noncovalent interactions. Inspired by nature's craftsmanship in designing motion, supramolecular "host-guest" chemistry has emerged as a powerful strategy for creating s... |
41556470 | A cytosine-silver incorporated metal-organic framework for efficient laccase-mimicking reactions. | Nucleobases are essential components of nucleic acids and provide multiple coordination sites, making them useful ligands for metal-based catalysis. Purine-type nucleobases such as adenine and guanine have been widely studied because of their rigid structures and strong metal-binding ability, whereas the pyrimidine-typ... |
41532827 | Recent progress in supramolecular coordination complexes for bacterial diagnosis and treatment. | Bacterial infections are exacerbated by antibiotic resistance and biofilm formation, posing a serious threat to global health. At present, treatment methods that mainly rely on antibiotics are increasingly challenged by antibiotic resistance, and thus innovative solutions are needed. Supramolecular coordination complex... |
41510698 | Unveiling n → π* interactions: convergence of quantum crystallography and computational insights. | We report the identification and characterization of a n → π* interaction between halide anions and a cationic purine nucleobase. Through a combined quantum crystallographic and computational approach, we demonstrate that perpendicular anion⋯(sp<sup>2</sup>)carbon contacts occur consistently at the C2 position of the p... |
41993607 | Demethoxycurcumin exhibits amoebicidal activity against <i>Acanthamoeba triangularis</i> trophozoites and cysts and inhibits encystation. | <i>Acanthamoeba</i> is a ubiquitous free-living protist commonly found in soil and water, with the T4 genotype responsible for most human infections. Treatment remains challenging due to the limited efficacy of current therapeutics and the parasite's ability to form a highly resistant double-walled cyst. In this study,... |
41890264 | Functional hydrogels as submucosal injectable materials in therapeutic endoscopy. | Therapeutic endoscopy, including endoscopic submucosal dissection (ESD), has transformed the management of early gastrointestinal (GI) cancers by enabling the resection of large and complex lesions. However, its widespread adoption remains limited by technical difficulty and the high risk of complications such as bleed... |
41868254 | Underexplored Dimensions of Emerging Indoor Photovoltaics. | Indoor photovoltaics (IPVs) can significantly reduce reliance on disposable batteries in Internet of Things (IoT) devices. Yet, most evaluations use idealized lighting setups and single performance metrics, neglecting the influence of real indoor environments on device performance. This Perspective advances a deploymen... |
41859600 | Body Under Attack: Disseminated Varicella-Zoster Virus Infection. | Varicella-zoster virus (VZV) infection is typically benign and self-limiting. In adults, it most commonly manifests as a localized cutaneous infection. However, in immunocompromised individuals, VZV can undergo hematogenous dissemination and cause severe visceral involvement, including pulmonary, hepatic, pancreatic, c... |
41836188 | Cell-Laden Supramolecular and Covalent Polymer Hydrogels for High-Shear Delivery: A Design of Experiments Approach. | Effective design of cell-delivery scaffolds is of key importance for regenerative medicine technologies to meet their full potential, especially when considering cell delivery to wounds of complex architecture or directly into the biological environment. Few studies, however, focus on a systematic approach to understan... |
41822171 | Vibrational snapshots of ultrafast C-H bond photoactivation inside a water-soluble nanocage. | Triggering C-H bond photoactivation reactions inside enzyme-like nanocavities will enable development of green methods to carry out selective organic transformations in water. Recently it was shown that host-guest charge transfer (CT) interactions inside water-soluble cationic nanocages can be used to drive ultrafast C... |
41816116 | From Formation to Failure: The Role of Hydrogen Peroxide in Proton Exchange Membrane Technologies. | Hydrogen peroxide is a catalytic byproduct in proton exchange membrane fuel cells (PEMFCs) and proton exchange membrane water electrolyzers (PEMWEs). It may be produced as a side product of the electrochemical processes occurring at the cathode in PEMFCs, or at the anode in PEMWEs, or it may be produced due to gas cros... |
41799146 | Procyanidin Capsules Relieve Inflammation in Hypertriglyceridemic Acute Pancreatitis via Regulating Oxidative Phosphorylation Signaling. | Hypertriglyceridemic acute pancreatitis (HAP) is characterized by mitochondrial oxidative phosphorylation (OXPHOS) impairment and excessive reactive oxygen species (ROS), leading to severe inflammation and organ damage. Existing therapies often lack targeted antioxidant efficacy and long-term stability. In this study, ... |
41799132 | Supramolecular Engineering of Melamine-Barbiturate Assemblies for Polyphenol Encapsulation and Antioxidant Delivery. | Supramolecular assemblies of melamine-barbituric acid (Mel-BA) were engineered for the controlled encapsulation of polyphenols, as exemplified by epicatechin (EC). Quantum chemical (DFT) calculations verified the thermodynamic viability of incorporation, although steric and geometric constraints introduced structural d... |
41799107 | Hybrid Cellulose Acetate Films with Carbon and Cellulose Nanostructures for Enhancing Its Properties: Structural, Mechanical, and Liquid Crystal Properties. | This work deals with providing a perspective for promoting the performance of cellulose acetate (CA) by carbon and cellulose nanostructures (NSs) and sustainable upcycling of their metal-loaded wastes. The assessment of these CA-hybrid films was carried out in contrast to films from esterified NSs (as additives) and es... |
41788290 | Incorporation of Ion Transport Chains into Multivariate MOF for Improved Water Oxidation. | The climate crisis demands clean energy technologies to cut CO<sub>2</sub> emissions from fossil fuels. Hydrogen fuel cells and solar-driven CO<sub>2</sub> reduction are promising, but both rely on efficient water oxidation. Polypyridyl ruthenium complexes are active catalysts for water oxidation; however, they exhibit... |
41778261 | Cholesterol depletion inhibits BDNF-dependent spike timing-dependent plasticity at thalamo-amygdala synapses. | The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a key regulator of synaptic plasticity in hippocampus and cortex of mammalian brains. In the lateral nucleus of the amygdala (LA), BDNF is involved in the control of long-term potentiation (LTP). Here, we show that BDNF is involved in spike-timing... |
41778049 | <i>In silico</i> interaction analysis of selected natural compounds with bacteriophage-encoded hyaluronate lyase from <i>Streptococcus pyogenes</i>. | <h4>Introduction</h4>The rising antibiotic resistance of <i>Streptococcus pyogenes</i> necessitates alternative anti-virulence strategies. Bacteriophage-encoded hyaluronate lyase (HylP2), a key virulence factor that promotes bacterial dissemination by degrading host extracellular matrix components, represents an attrac... |
41778020 | Inflammatory bowel disease through the lens of microbe-host interactions: immunomodulation, metabolic effects, and genetic susceptibility in microbiota dysbiosis. | Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, and inflammatory bowel disease-unclassified, is a complex intestinal disease influenced by microbial factors, genetic and environmental. IBD has become a global disease with an increasing prevalence, endangering human health worldwide. Thr... |
41777735 | Spinal motor neuron degeneration after brachial plexus avulsion: mechanisms and therapeutic targets. | Brachial plexus avulsion injury (BPAI) causes violent detachment of cervical ventral roots and rapid degeneration of spinal motor neurons (SMNs), driven by abrupt energy failure, axonal disconnection, and a rapidly escalating neuroinflammatory microenvironment. Current evidence demonstrates that SMN loss arises from th... |
41777667 | Nucleolus as a cornerstone linking proliferation and metabolism to cellular responses to stress: involvement of transcription factors MYC and p53. | The nucleoli are a dynamic membraneless organelles in the nucleus playing a key role in cellular homeostasis. Transcription of rDNA, processing of rRNA, and assembly of the ribosomal subunits occur in nucleoli. Aside from ribosome biogenesis, the nucleolus is also involved in the regulation of other crucial functions, ... |
41777629 | Dual-pathway detoxification by <i>Dendrobium nobile</i> Lindl. Polysaccharide: concurrent suppression of bound heterocyclic amine release and heterocyclic amine-elicited cytotoxicity during gastrointestinal digestion. | This study investigated <i>Dendrobium nobile</i> Lindl. polysaccharides (DNP) for their effects on bound heterocyclic amine (HAs) release in beef patties, myofibrillar protein (MP) and sarcoplasmic protein (SP) models. Furthermore, the potential of DNP to mitigate free HA-induced cytotoxicity was evaluated. In vitro di... |
41777367 | The Effect of Nanoparticle Shape, Orientation, and Heterogeneity on the Optical Birefringence of Polymer Nanocomposites. | Embedding plasmonic nanoparticles (NPs) into polymer nanocomposites (PNCs) is a facile method for integrating them into functional devices, whose properties are tunable through varying NP size, shape, and loading. Using anisotropic NPs adds an additional degree of tunability to their orientation order in the PNC, as pr... |
41769379 | Charge/stiffness-tunable nano-microsphere overcomes intestinal mucosal barrier for rheumatoid arthritis treatment. | Intestinal drug delivery is a crucial route for rheumatoid arthritis (RA) therapy. However, its effectiveness is often hampered by the viscosity gradient of the mucus layer and the selective degradation and efflux functions of the epithelial barrier. To address these challenges, we developed a nano-microsphere system f... |
41769378 | Multifunctional implantable hydrogels: Smart platforms at the forefront of biomedical innovation. | Hydrogels are transformative three-dimensional polymeric networks that replicate the extracellular matrix owing to their high-water content, biocompatibility, and tunable physicochemical properties. Evolving beyond conventional applications in wound dressings, contact lenses, and basic drug depots, hydrogel systems hav... |
41751479 | Comparative Analysis of Methodological Aspects of the Study of Extracellular Vesicles and Extracellular Mitochondria: From Isolation to Internalization. | Mitochondrial transfer in mammals has been proven to occur both under physiological conditions and during pathological conditions. It has been shown that neighboring cells can exchange mitochondria via nanotunnel tubes. However, there is evidence that free mitochondria, as well as whole mitochondria and individual mito... |
41751477 | Scissor-CIBERSORTx Deconvolution Reveals Functional Heterogeneity of CTAL/aTAL Cells and Associated Biomarkers in Renal Fibrosis. | Renal fibrosis (RF) represents a major pathological outcome of chronic kidney disease, currently accompanied by extremely limited therapeutic strategies. To decipher key cellular and molecular drivers, we integrated single-cell and bulk transcriptomic profiles for comprehensive analysis. Based on the RF-related single-... |
41744741 | Optical Biosensors for Blood Coagulation Monitoring: Advantages, Limitations, and Translational Potential. | Dynamic monitoring of hemostatic equilibrium is indispensable for clinical safety in high-risk scenarios, while current clinical methods are limited by sample volume, detection speed, and physiological relevance. These shortcomings underscore the demand for novel sensing platforms. Optical biosensors, leveraging label-... |
41744594 | Nacre and Nacre-Inspired Materials: Historical Background, Definition, Fabrication Techniques and Gaps. | From Palaeolithic ornaments to modern biomimetics, the use of nacre and shells has evolved. Initially utilised for jewellery and tools, they now inspire the development of advanced materials. This paper reviews the current knowledge on nacre's composition, focusing on the highly regulated biomineralisation process wher... |
41743835 | Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration. | Osteochondral tissue comprises two structurally and functionally distinct regions: An avascular, low-cellularity cartilage layer with poor self-healing capacity, and a vascularized, mineralized subchondral bone. This pronounced heterogeneity complicates the repair of defects that span both regions. Conventional clinica... |
41737040 | Nanotechnology-Assisted Molecular Profiling: Emerging Advances in Circulating Tumor DNA Detection. | Tumor-derived circulating cell-free DNA (ctDNA) has emerged as a pivotal biomarker for non-invasive cancer diagnosis, treatment monitoring, and prognostic evaluation. However, its inherently low abundance, high fragmentation, and rapid degradation impose stringent requirements on assay sensitivity, specificity, and ana... |
41737038 | GelMA-Based Nanocomposites for Bone Defect Regeneration: Design, Performance, and Clinical Translation Potential. | This narrative review summarizes recent advances in gelatin methacryloyl (GelMA)-based nanocomposites for bone defect regeneration, addressing the persistent clinical need for effective and customizable bone repair strategies. As an extracellular matrix (ECM)-mimicking hydrogel, GelMA offers favourable biocompatibility... |
41730821 | Proteoliposomes containing ATPase as microreactors to mimic microbial metabolism for bioenergy synthesis. | Learning and imitating the inherent metabolic pathways of organisms in nature has emerged as a crucial approach to achieve artificial biomimetic synthesis of Adenosine triphosphate (ATP). We have constructed a biomimetic microreactor inspired by the ethanol metabolism pathway in microorganisms. The alcohol dehydrogenas... |
41728079 | Carbazole-benzocarbazole fragments having derivative as very efficient host material for TADF based OLEDs. | Organic light-emitting diodes (OLEDs) are widely adopted in modern display and lighting technologies; however, while significant progress has been achieved in the development of thermally activated delayed fluorescence (TADF) emitters, comparatively limited attention has been paid to the rational design of compatible h... |
41726370 | <i>In Silico</i> Design and Analysis of a Novel Ranibizumab-derived Peptide against the Vascular Endothelial Growth Factor. | <h4>Purpose</h4>Blocking the interaction between vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR2) is recognized as an effective strategy for treating neovascular age-related macular degeneration (nAMD). The present research aimed at designing and modelling an anti-VEG... |
41725887 | Nanoparticles Targeting the Tumor Microenvironment for the Treatment of Osteosarcoma: Recent Progress and Perspectives. | Osteosarcoma (OS) is the most common primary malignant bone tumor, with two incidence peaks: one in adolescence and the other in older individuals. Despite significant research, patient prognosis has not substantially improved in recent decades because of a limited understanding of its pathogenesis and a lack of innova... |
41723995 | A facile surface enhanced Raman scattering-colorimetric dual-mode sensor based on epitope molecularly imprinted polymer for diverse assay of carcinoembryonic antigen. | Carcinoembryonic antigen (CEA) is a key serum biomarker in colon cancer early screening. Herein, we established a surface enhanced Raman scattering (SERS)-colorimetric dual-mode sensor for CEA assay by employing Au nanostar@Ag@Pt (AuNS@Ag@Pt) nanonzyme as the signaling element. Epitope molecularly imprinted polymer bas... |
41722454 | Aptamer-functionalized mesoporous metal-organic framework with ultrahigh adsorption capacity for selective isolation of lactoferrin. | Mesoporous Zr-based MOF material MPAUiO was prepared by nanoemulsion-guided assembly technology using polyether compound as soft template, then modified with lactoferrin aptamer (LFA) via Schiff-base reaction to give aptamer-functionalized mesoporous composite LFA@MPAUiO. The multiple hydrogen-bonding interactions betw... |
41719964 | Rapid detection of Bacillus subtilis in complex fermentation environment by robust and efficient dual-ligand metal-organic framework and aptamer. | Bacillus subtilis is one of the dominant bacteria in high-temperature Daqu of jiang-flavor baijiu. The heat-resistant enzymes and pyrazine compounds produced by Bacillus subtilis are crucial to the formation of jiang flavor. This study introduced a highly sensitive and specific biosensor for the detection of B. subtili... |
41719931 | Multi-target and highly selective halogenated disinfection byproducts detection based on micelle-based clusteroluminescence. | Halogenated byproducts from the disinfection of domestic wastewater and drinking water are highly toxic in water environment. The multi-target and selective detection of halogenated byproducts is still a challenge due to their inherent similarity in molecular structures. Herein, we propose a multifunctional sensing pla... |
41713344 | Self-assembled 8-shogaol/curcumin nanoparticles via hydrogen bonding: enhanced stability and sustained release in vitro. | This study synthesized curcumin/polyvinyl pyrrolidone (PVP)/8-shogaol nanoparticles (PCS-NPs) loaded with 8-shogaol using hydrogen bonding self-assembly. Firstly, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), <sup>1</sup>H NMR spectrometer and other techniques were used to char... |
41712986 | A water-stable La-MOF as a dual-target sensor for selective and rapid detection of guanosine and arginine in biological and food system. | Lanthanide-based metal-organic frameworks (MOFs) have emerged as promising sensing platforms, attracting significant research interest due to their potential for high-performance detection, with applications in biological and food systems. In this work, a novel and robust MOF (La-CIP) was fabricated through the coordin... |
41710086 | The Diverse Roles of the Histone-Like Nucleoid Structuring (H-NS) Protein in <i>Vibrio parahaemolyticus</i>. | The histone-like nucleoid structuring (H-NS) protein is a global transcriptional regulator critical for bacterial genome organization and gene expression. In <i>Vibrio parahaemolyticus</i>, H-NS represses virulence factors such as thermostable direct hemolysin (TDH), type III secretion systems (T3SS1/T3SS2), and type V... |
41708000 | Sialylation in the nervous system: Functions and mechanisms. | Glycoprotein sialylation represents a critical posttranslational modification with diverse biological roles in animals. This review explores its multifaceted functions in the nervous system, with particular emphasis on neurophysiology, homeostasis, and associated neurological disorders. The sialylation pathway modulate... |
41708001 | The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties. | Human parathyroid hormone (PTH), which regulates the calcium and phosphate levels in blood, forms functional amyloid fibrils, which are believed to be the storage form during secretion from parathyroid glands. We investigated by various biophysical approaches the role of the intrinsically disordered C-terminal section ... |
41707789 | The host-guest inclusion complex of Anle 138b with Methyl-β-cyclodextrin: In vitro characterization and possible formulation development for anti-Parkinson application. | Anle 138b has been studied as anti-Parkinson disease (PD) drug, whose mechanism consists of the inhibition of α-synuclein (α-syn) aggregation. Its aqueous solubility was found less than 1 μM at 25 °C and, hence, no liquid formulation has been investigated for the pharmaceutical market. In the present study, we consider... |
41707771 | Bone-targeting β-cyclodextrin phosphate has anti-resorptive activity and thereby prevents osteoporosis. | Osteoporosis is a common bone disease that weakens and fragilizes the bones. A wide variety of osteoporosis medicines are available; however, the long-term use of such medicines is not recommended because of major adverse effects. Therefore, the development of effective and safe therapeutic drugs is urgently required. ... |
41707262 | Modulation of protein self-assembly via hydrolysis and metal ion coordination: Effects on EGCG encapsulation and controlled release. | To enhance the stability of EGCG-encapsulated protein carriers under processing and preservation, a zinc-mediated self-assembly strategy was developed. Limited protein hydrolysis combined with cyclodextrin pre-encapsulation was employed to regulate the encapsulation and release of EGCG. Cyclodextrin pre-encapsulation e... |
41705152 | Photodynamic Strategies for Prevention of Titanium Osteoimplant Infections. | The growing demand for orthopedic implants, driven by an aging global population and the rising occurrence of bone abnormalities and defects, relies heavily on biocompatible titanium (Ti) and its alloys. However, their inherent biological inertness often results in poor osseointegration and increased vulnerability to b... |
41704461 | Effective removal of antibiotics from aqueous solutions by a robust activated carbon: experimental and theoretical study. | The continuous discharge of antibiotics into water bodies is a potential threat to the ecosystem. We prepared a coal-based activated carbon and characterized it <i>via</i> BET, SEM, FTIR spectroscopy, XRD, TEM, TGA and Raman spectroscopy. Its surface area was 3470 m<sup>2</sup> g<sup>-1</sup>, and its pore size and vol... |
41704456 | A new multifunctional one-dimensional bromo-bismuthate(iii): synthesis, structural features, characterization, and optical properties of (C<sub>10</sub>H<sub>13</sub>N<sub>4</sub>)[BiBr<sub>4</sub>]·2H<sub>2</sub>O. | A new one-dimensional bromobismuthate(iii) organic-inorganic hybrid (C<sub>10</sub>H<sub>13</sub>N<sub>4</sub>)[BiBr<sub>4</sub>]·2H<sub>2</sub>O, was successfully synthesized and comprehensively investigated to elucidate its structural, thermal, and optoelectronic characteristics. Single-crystal X-ray diffraction esta... |
41699912 | Kinetically Trapped Ligand Binding in DNA Tandem Repeats. | Tandem DNA repeats are ubiquitous in the human genome. They often exist in microsatellite and minisatellite domains, serving as targets for transcription factors and small molecules in gene regulation. Investigation of ligand binding to tandem DNA repeats is rather challenging using traditional methods, such as NMR spe... |
41699819 | Liposome-Encapsulated Carfilzomib as a Radiosensitizer in Solid Tumors. | Chemoradiotherapy is a common treatment option for many cancers. Carfilzomib (CFZ) is an effective chemotherapeutic drug with a multitude of cellular effects. However, CFZ has yet to be studied in the context of chemoradiotherapy. To study the application of CFZ in chemoradiotherapy, we synthesized CFZ-loaded liposomes... |
41699684 | The metabolite α-ketoglutarate induces AIM2-dependent PANoptosis through demethylase TET2. | While α-ketoglutarate (α-KG) has traditionally been viewed as an anti-inflammatory metabolite, we uncover its paradoxical role in driving pathological inflammation during sepsis. This study reveals that α-KG, a tricarboxylic acid cycle (TCA) intermediate elevated in septic patients, drives inflammatory macrophage death... |
41699661 | NAT10 and ac4C modification in cancer immunity and metabolism: emerging mechanisms and therapeutic potential. | <h4>Background</h4>Tumor immunity and metabolism are interconnected through the tumor microenvironment (TME), with RNA modifications playing pivotal epigenetic regulatory roles. N4- acetylcytidine (ac4C) is the first acetylated modification identified on eukaryotic RNAs, and N- acetyltransferase 10 (NAT10) is the key e... |
41699655 | Polyphenolic nanodot-integrated spindle nanoplatform heals oral mucositis via microbiota restoration and glycolysis inhibition. | Oral mucositis (OM) is a debilitating complication occuring in most patients receiving chemotherapy. Through correlation analysis of oral microbiota sequencing data with host metabolomics data, we confirmed that disruption of the oral microbiota (dysbiosis) could lead to changes in metabolic activity in mucosal tissues... |
41699649 | Natural based Fe<sub>3</sub>O<sub>4</sub>@β-CD-MoO<sub>3</sub> as an oxidizing catalyst. | Pomegranate peels are a rich source of polyphenolic compounds, particularly ellagitannins and gallotannins, which were utilized as natural substrates for the synthesis of a novel catalyst. A magnetic oxidizing material was developed by covalently anchoring β-CD/MoO<sub>3</sub> onto a magnetic support derived from pomeg... |
41699645 | Nanomaterials as electrochemical regulators of bacterial biofilms through the modulation of extracellular electron transport and ion channels. | Bacterial biofilms employ complex electrochemical communication networks, primarily mediated through extracellular electron transfer (EET) and ion channel-dependent signaling, to coordinate metabolic activities and collective behaviors. Recent advances in nanotechnology have unveiled the potential of nanomaterials as n... |
41699600 | Biomineralized OMV-based nanocomposite orchestrates cascade-amplified antitumor immunity via eliciting dual pyroptosis and blocking autophagy. | Apoptosis resistance, the severely immunosuppressive tumor microenvironment (TME), and the self-adaptive survival mechanisms of tumor cells significantly impair the efficacy of tumor therapies, driving us to seek more effective antitumor therapeutics that can induce devastative tumor death modalities. Herein, we presen... |
41699396 | 14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering. | In cancer cells, Ras protein mutations activate a signaling cascade that phosphorylates kinases, transcription, and translation factors, driving cancer cell proliferation. One such factor, FOXO3a, promotes apoptosis-related gene transcription. However, in many cancer cells, FOXO3a is phosphorylated and is bound to 14-3... |
41699197 | STAT1 signaling controls cholesterol metabolism in epithelial cells and RSV-induced syncytia formation. | Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections, leading to significant morbidity, hospitalizations, and mortality among high-risk populations. Despite the recent advent of vaccines and monoclonal antibodies, options to treat RSV infections are limited. Detailed understanding at the... |
41699076 | Reverse vaccinology-based design of a universal multiepitope vaccine against chikungunya virus: Phylogenetic and immunoinformatics approaches. | Chikungunya virus (CHIKV) infection is a re-emerging arboviral disease in tropical and subtropical regions. In addition to acute febrile syndrome, CHIKV infection may lead to chronic articular manifestations that significantly affect a long-term quality of life. This study aimed to design a universal vaccine candidate ... |
41699017 | Diversity of specialized metabolites in Phaeoacremonium species revealed by untargeted metabolomics and bioactivity assays. | Fungi belonging to the genus Phaeoacremonium are recognized as cross-kingdom pathogens, that affect both agricultural crops and human health. Here, we report the first comprehensive large-scale chemotaxonomic study based on untargeted MS-based metabolomics of 28 isolates representing 24 Phaeoacremonium species. The che... |
41698998 | The antibacterial effectiveness of fourth-generation poly-amidoamine dendrimers-loaded with amoxicillin in combating methicillin-resistant Staphylococcus aureus. | In the community and in healthcare, methicillin-resistant Staphylococcus aureus (MRSA) is a major concern. Numerous infections with significant rates of morbidity and mortality are caused by MRSA strains worldwide. The widespread synthesis of virulence components is what makes MRSA so successful. The increasing resista... |
41698972 | An engineered M13 phage-rGO electrochemical biosensor for rapid detection of viral protein in complex matrices. | The demand for rapid and scalable biosensing technologies has motivated the development of antibody-free platforms capable of operating in complex sample environments. Here, we report an electrochemical biosensor based on engineered M13 bacteriophages displaying a SARS-CoV-2 spike S1-binding peptide immobilized on a re... |
41698963 | A novel approach to silver nanoparticle biosynthesis using ursolic acid from Catharanthus roseus for therapeutic effects. | The present study attentive on the bio synthesis of silver nanoparticles (AgNPs) using ursolic acid (UA-AgNPs) isolated from Catharanthus roseus and investigated their antibacterial, antibiofilm, antioxidant, anti-inflammatory, and anticancer activities. The biosynthesized UA-AgNPs were characterized using techniques l... |
41698953 | Molecular electronic chirality in copper phthalocyanine induced via twisted π-π stacking on bilayer graphene. | Electronic chirality within single molecules constitutes an intriguing phenomenon in quantum chemistry, whose inducing mechanism however remains underexplored. Here, we report a distinct formation mechanism for electronic chirality in CuPc molecules adsorbed on bilayer graphene on highly oriented pyrolytic graphite, as... |
41698924 | Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus. | Arginine, lysine, and ornithine are critical to several fundamental aspects of organismal physiology, including protein structure and function, the urea cycle, and intracellular signaling. These cationic amino acids are imported by several membrane transporters, most notably the Cationic Amino acid Transporters (CATs) ... |
41698922 | Supercoiled DNA recognition and cleavage control in topoisomerase VI. | Type II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 further serve to initiate meiotic recombination i... |
41698919 | Decoupling phase separation and fibrillization preserves activity of biomolecular condensates. | The age-dependent transition of metastable, liquid-like protein condensates to amyloid fibrils is an emergent phenomenon in numerous neurodegeneration-linked protein systems. A key question is whether the thermodynamic driving forces underlying phase separation and maturation to amyloid fibrils are distinct and separab... |
41698915 | T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2<sup>+</sup> solid and hematologic cancers. | Although chimeric antigen receptor (CAR)-T cells are promising effector cells to treat hematologic tumors, developing effective CAR-T cells for solid tumors remains challenging. Dickkopf-1 (DKK1) protein is widely expressed by human hematologic and solid tumors. Using the sequence of murine or humanized monoclonal anti... |
41698907 | A universal strategy towards self-healing materials via dynamic interfacial liquid metal coordination. | Self-healing polymer materials, capable of autonomously repairing physical damage, have been broadly applied in modern technologies. In various self-healing systems, metal-ligand coordination bonds have been extensively utilized for their advantages of rich metal-ligand species and functionalities. However, common meta... |
41698895 | Mass spectrometry reveals the evolutionary conservation of phycobiliprotein complexes. | Cyanobacteria are a highly taxonomically and ecologically diverse group of oxygenic phototrophs that have colonized many different environments on our planet. Despite their differences, almost all cyanobacteria rely on highly efficient light-harvesting protein complexes, termed phycobilisomes, for effective photosynthe... |
41698894 | "On-water" photosensitization enables redox neutral acylation and alkylation of quinones. | Water-oil interfaces exhibit a high cohesive energy density and form a supramolecular hydrogen-bonding network that supports organic reactions in various ways. Here, we introduce the redox-neutral photo-Friedel-Crafts acylation and alkylation of quinones at the aqueous-organic interface. Spectroscopic evidence and comp... |
41698874 | Ru Nanoparticles Ligated by an N-Heterocyclic Carbene Derived from Uracil Nucleoside as Selective Antimicrobial Agents. | Metal nanoparticles (MNPs) effectively combat pathogens due to their nonspecific toxicity, reducing the chance of bacterial resistance. Natural-based stabilizing ligands enhance the stability and targeting of MNPs while minimizing toxicity to human cells. In this context, ura-NHC-stabilized Ru NPs (<b>Ru@ura-NHC</b>) h... |
41698352 | Precise Optical Modulation of Charge Transport in 2D Organic Molecular Crystals through Tailor-Designed Photoswitchable Guest-Host Architectures. | Two-dimensional organic molecular crystals (2DOMCs) have emerged as promising candidates for next-generation ultrathin electronics. However, precisely and reversibly modulating their charge-transport characteristics remains a significant challenge. Herein, we report a molecular engineering strategy to create light-prog... |
41698062 | Attenuated Bacteria-Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies. | Bacteria-based cancer therapy is a promising cancer treatment strategy that utilizes genetically engineered attenuated bacteria to specifically target tumor tissues, directly kill cancer cells, or activate the host's immune response. Engineering modifications of attenuated bacteria can achieve more effective anti-tumor... |
41698054 | Polymer-in-Cage Strategy for Pore Tuning of High-Aspect Ratio ZIF Nanoplate: Toward Sub-Micrometer-Thick Large Area CO<sub>2</sub> Separation Membranes. | Mixed-matrix membranes (MMMs) offer a promising route for CO<sub>2</sub> separation, yet their potential is often limited by poor polymer-filler interfaces and challenges in integrating high-aspect-ratio fillers into scalable, defect-free thin-film composite (TFC) membranes. Here, we introduce a "polymer-in-cage" strat... |
41698050 | Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation. | Cyclopeptide alkaloids are an expanding class of plant peptide natural products defined by a macrocyclic ether cross-link via a tyrosine-derived phenol. Classical cyclopeptide alkaloids are characterized by strained 13- to 15-membered cyclophanes and terminal modifications such as <i>N</i>-methylation and C-terminal st... |
41698045 | Selective Mineral Recovery from Seawater by Ion-Exchangeable Metal-Organic Framework Glasses. | The transition to clean energy and sustainable technologies necessitates securing strategic materials, yet traditional land-based mining is increasingly unsustainable. Seawater holds immense potential as a mineral source, but its intricate ionic composition limits current extraction techniques. Here, we report a family... |
41697901 | Cholesterol inhibits capsaicin activation of the TRPV1 channel. | TRPV1 is a polymodal ion channel activated by vanilloids, noxious heat, and pro-inflammatory signals. A recent cryo-EM structure of human TRPV1 bound to SAF312, a potent, selective, noncompetitive antagonist, revealed a cholesterol molecule occupying the vanilloid-binding pocket, a site well established as the activati... |
41697876 | Rational Design of High-Quality ZIF-8 Membranes: Machine Learning-Guided Optimization of ALD ZnO Conversion. | Converting atomic layer deposited (ALD) ZnO thin films into high-quality zeolitic imidazolate framework-8 (ZIF-8) membranes poses significant challenges in identifying optimal synthesis conditions. This study employs a comprehensive machine learning approach to predict conversion outcomes based on 68 experimental condi... |
41697869 | Tea (<i>Camellia sinensis</i>) Extract-Mediated Green Synthesis of Co<sub>3</sub>O<sub>4</sub> and Co<sub>3</sub>O<sub>4</sub>@Graphene Nanocomposites for Multifunctional Applications in Pollutant Degradation, Sensing, and Energy Storage. | A novel solution-mixing method was proposed to synthesize Co<sub>3</sub>O<sub>4</sub>/graphene nanocomposites (Co<sub>3</sub>O<sub>4</sub>@Gr) using a green tea leaf (<i>Camellia sinensis</i>) extract as the reducing agent. XRD analysis shows that the as-prepared Co<sub>3</sub>O<sub>4</sub>@Gr exhibits a cubic spinel c... |
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