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41650271 | Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders. | Cyclic peptides exhibit advantages in binding protein targets with high affinity and competency in inhibiting protein-protein interactions. Cyclic peptide phage display with more than a billion variants is an invaluable tool in drug discovery. However, achieving efficient peptide cyclization on phages remains a challen... |
41650237 | Hydration gradients drive lipid self-segregation. | Evaporation from a multicomponent aqueous mixture not only establishes a hydration gradient but may also lead to composition gradients in the other components. Here, we show that such a gradient induces a strong segregation between two phospholipids that differ only in the saturation of their acyl chains. Using high-re... |
41650229 | Intramolecular noncovalent trans ring restricting free rotation of σ single bond enhances photosynthesis of hydrogen peroxide. | Solar energy-driven hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) synthesis from atmospheric oxygen and water represents a sustainable and highly promising avenue for the production of this essential chemical. Covalent organic frameworks (COFs) offer a molecular platform for the direct conversion of solar energy to H<... |
41650115 | Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy. | Cisplatin (CIS) remains a cornerstone of chemotherapy but is limited by resistance and systemic toxicity. Combining DNA-damaging agents with epigenetic modulators such as vorinostat (VOR) offers a promising strategy to enhance efficacy. However, the co-delivery of these drugs is challenging due to their distinct physic... |
41650013 | Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus. | Of the seven serotypes of foot-and-mouth disease virus (FMDV) strains circulating globally, serotype Asia1 has been effectively eradicated in China through systematic vaccination in livestock. The structural characteristics of serotype Asia1 may enhance its immunogenicity compared to other serotypes. Herein, we present... |
41650005 | Robust Functionalized Cotton Fabrics with Zr-Based Tetrahedral Cages for Degrading a Chemical Warfare Agent Simulant. | The resurgence of chemical warfare agents (CWAs) in recent decades underscores the urgent need for efficient and durable personal protective equipment (PPE). Conventional systems employing zeolites or activated carbons provide only passive protection via adsorption and suffer from limited porosity, low catalytic activi... |
41649969 | Synergistic Covalent and Supramolecular Polymer Networks Enabled by Unsymmetrical Topological Nodes. | Achieving efficient synergy between covalent and supramolecular polymers is an effective strategy for developing novel polymeric materials. However, realizing this synergy through rational chemical design to efficiently integrate both types of polymers within a single polymer network remains a significant challenge. He... |
41649900 | CRISPR-Cas13a-Powered Electrochemical Biosensor for Label-Free Detection of Chikungunya Virus RNA Using a Ceria-Modified Screen-Printed Carbon Electrode. | This study aims to develop a label-free electrochemical biosensor for the detection of chikungunya virus (CHIKV) RNA, based on CRISPR-Cas13a integrated with a cerium oxide (ceria)-modified screen-printed carbon electrode (SPCE). The ceria film was deposited through cathodic electrodeposition, forming a uniform, needle-... |
41649836 | A C<sub>1</sub>-Homologative Trifluoromethylation: Light-Driven Decarboxylative Trifluoroethylation of Carboxylic Acids. | The incorporation of fluorinated alkyl groups is a powerful strategy to fine-tune the physicochemical and biological properties of organic molecules. In particular, the trifluoroethyl (-CH<sub>2</sub>CF<sub>3</sub>) substituent offers a valuable C<sub>1</sub>-homologated analogue of trifluoromethylated motifs, yet meth... |
41649809 | Decoding the Post-translational Modification Crosstalk: Functional Implications of Phosphorylation, Acetylation, and Methylation. | Post-translational modifications (PTMs) such as phosphorylation, acetylation, and methylation critically expand proteome function by regulating protein structure and interactions. Hydropathy changes serve as a main driving force; however, a quantitative, mechanistic understanding of how their distinct chemical changes ... |
41649718 | A new <sup>68</sup>Ga-labeled dimeric FAP ligand to advance targeted PET imaging of cancer. | <h4>Background</h4>Fibroblast activation protein (FAP) has emerged as a critical biomarker in the tumor microenvironment of various cancers. Radioligands targeting FAP have shown promise for cancer theranostics. To advance cancer imaging, we synthesized a dimeric radioligand based on a 4-quinolinoyl-glycyl-2-cyanopyrro... |
41649705 | Nanoparticle approaches for hepatitis therapy and clinical translation. | <h4>Background</h4>Hepatitis B and C viruses (HBV and HCV) remain major global health challenges, contributing significantly to liver-related morbidity and mortality worldwide. Although direct-acting antivirals (DAAs) have improved patient outcomes, key limitations persist, including suboptimal hepatic targeting, emerg... |
41649382 | Three-Dimensional Fluorescence Fingerprint Integrated PCR Enables Accurate Analysis of 9 Pathogens. | Rapid and accurate identification of respiratory tract infections is a critical clinical need, with current diagnostic approaches predominantly relying on culture isolation, immunological testing, and molecular biology techniques. Although PCR-based methods have gained clinical acceptance due to their specificity and s... |
41649332 | Identifying Structural Factors Governing the Photodynamic Activity of Phthalocyanines. | Phthalocyanines (Pcs) are promising photosensitizers (PSs) for photodynamic therapy (PDT). However, the variability in experimental conditions in <i>in vitro</i> experiments among reported derivatives complicates clear comparisons. In this study, we systematically evaluated a diverse set of more than 40 cationic, anion... |
41649287 | Development of nanobody-conjugated LL37 for synergistic therapy against MDR <i>Acinetobacter baumannii</i>. | Multidrug resistance (MDR) of the pathogen <i>Acinetobacter baumannii</i> is a major challenge to global healthcare due to the limited treatment options. The emergence of MDR bacteria necessitates innovative therapeutic approaches, especially given the associated economic burden and the rapid spread of infections. Conv... |
41649267 | c-di-AMP-DasR signaling axis mediates mycobacterial acid resistance. | Pathogenic mycobacteria encounter acidic environments during host invasion, necessitating sophisticated acid resistance mechanisms. Here, we identify the GntR family regulator DasR as a conserved cyclic di-AMP (c-di-AMP) receptor in <i>Mycobacterium tuberculosis</i> that orchestrates acid adaptation through a multilaye... |
41649107 | Electronic Structure Modulation via Composition-Preserving Phase Transformations in Metal-Organic Assemblies on the Surface. | Supramolecular self-assemblies based on metal-organic coordination provide a tunable platform for constructing functional nanostructures on surfaces, with potential applications in catalysis, magnetism, and optoelectronics. Rational design of assemblies requires understanding how their electronic structures can be tune... |
41649085 | Self-Assembly of Unconventional Triphenylene-Based Frustrated Amphiphile in Solution. | Unconventional amphiphilic molecules having a rigid hydrophobic central unit and flexible or semiflexible hydrophilic chains on the rim have proven valuable in several technological applications, for example, host-guest chemistry. The further presence of alternating hydrophobic and hydrophilic tails complicates the def... |
41649057 | Solvent-Regulated CPL Enhancement via Chiral Transfer in Efficient Luminescent Ionic Hydrogen-Bonded Frameworks for Information Encryption. | Circularly polarized luminescence (CPL) materials have garnered significant attention due to their broad application prospects in information-encryption and optical storage. However, chiral small-molecule systems face challenges such as intramolecular chiral-transfer confinement and low energy transfer efficiency, maki... |
41649052 | Structural biology of ferritin nanocages. | Ferritin is a ubiquitous and evolutionarily conserved iron-storage protein that plays a fundamental role in cellular iron homeostasis. By catalyzing the oxidation of ferrous iron and sequestering it as a ferric mineral within a protein nanocage, ferritin prevents toxic accumulation of labile iron and reactive oxygen sp... |
41649048 | Porphyrin-Geländer-Helical Conjugated Banister Type Porphyrin Dyads. | A new "Porphyrin-Geländer" (PoGe) macrocycle rac-PoGe[Zn, Zn] embodying a twisted butadiyne-linked porphyrin dyad as the banister was designed and synthesized according to a previously published successful design principle for Geländer molecules. The C<sub>2</sub>-symmetric properties of rac-PoGe[Zn, Zn] were revealed ... |
41648992 | Chain to Grid Supramolecular Assembly: Organometallic Ag(I) and Ag(I)-Au(I)-NHC Supramolecules with Tunable Optoelectronic Properties. | The multidentate hybrid C, N donor N-heterocyclic carbene ligand is used to synthesize an unprecedented Ag(I)-NHC complex and afford controllable assembly of an organometallic Ag(I)-Au(I)-NHC complex. Both experimental and theoretical studies were performed to characterize the organometallic linear chain Ag(I)-NHC poly... |
41646022 | Chirality Induced in Tetraethyllead through Noncovalent Interactions with a Chiral Tag. | Weakly bound complexes containing lead (Pb) were studied in a supersonic jet using broadband chirped-pulse Fourier transform microwave (CP-FTMW) spectroscopy, complemented with quantum-chemical calculations. These complexes were formed from a vapor mixture of tetraethyllead (TEL) and 2-(trifluoromethyl)oxirane (TFO), d... |
41645910 | Perylenediimide-Enhanced Ultra-Sensitive Turn-on Fluorescence Detection in Interpenetrated MOFs for Nerve Agent Simulants. | The urgent need for sensitive, selective, and rapid detection of nerve agents (NAs), a class of highly toxic organophosphorus compounds, has motivated the development of advanced fluorescent sensing materials. Herein, a series of interpenetrated luminescent metal-organic frameworks (MOFs) with 2,6-naphthalenedicarboxyl... |
41645887 | Sheath-Inspired Durable Semi-Convertible Hydrogel Enabled Controllable Lubrication and Contractibility. | The dynamic lubrication of sheath surrounding the tendon is significant to the motion of limbs. The sheath-inspired hydrogels for soft actuator and transplantable substitutes primarily focus on high toughness and intrinsic lubricating ability, it remains a significant challenge to design the hydrogels with secreting lu... |
41645845 | Synergistic Ion-Pair/Lewis Acid Catalysis Enables Enantioselective Synthesis of Helically Chiral Oxa[6]Helicenes. | Helicenes are privileged chiral architectures with exceptional optical and electronic properties, underpinning their importance in asymmetric catalysis, optoelectronics, and supramolecular chemistry. Despite significant progress in helicene synthesis, strategies for extending peripheral aromatic rings to access structu... |
41645775 | Xerogel-Derived Bis-Imidazole Semiconductors: Chain-Length-Controlled Gelation and Polycrystalline Blue OLED Emission. | The development of efficient and stable blue-light emissive organic materials that retain long-range structural order remains a key challenge for optoelectronic applications. Soft materials are a wonderful platform for fabricating various optoelectronic materials as they offer a unique opportunity to combine molecular ... |
41645752 | Role and mechanism of tetrahedral DNA nanostructures in the repair of urethral injury in rats. | Urethral injury is a common type of traumatic damage to the urinary system, often leading to urethral stricture, fibrosis and dysfunction, which significantly impair physiological function and quality of life. The present study aimed to investigate the therapeutic efficacy of the novel immune‑regulatory molecule tetrah... |
41645733 | Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review). | Sepsis is a life‑threatening clinical syndrome characterized by a dysregulated host immune response to infection, with its pathogenesis closely linked to the aberrant activation and dysfunction of various immune cells. The kidney is among the most vulnerable organs in sepsis. The development of acute kidney injury (AKI... |
41644827 | Metal-Organic Frameworks: Multifunctional Materials for High-Performance Zn-Halogen Batteries. | Aqueous zinc batteries are gaining attention as promising alternatives to Li-ion systems, owing to the increased need for safe and cost-effective energy storage. Aqueous Zn-halogen batteries are particularly important because of their low cost and the abundance of precursors. However, critical challenges, such as the s... |
41644539 | Machine learning unveils three layers of food complexity. | Food is a more complex system than commonly perceived, comprising tens of thousands of molecules whose compositions and interactions ultimately shape human perception. To conceptualize this multifaceted nature, we frame food complexity across three interconnected layers: the molecular composition that defines its chemi... |
41910152 | Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting. | <h4>Objective</h4>Designing a delivery system to target a drug to brain tumors (BT) is a complex process. Drug delivery to BT <i>presents a plethora of obstacles, such as poor bioavailability, drug targeting and its efficacy</i> due to the complexity of the brain's structure, anatomy, and implications of the blood-brai... |
41907378 | Developments & Potential of Nanotechnology for the Detection and Treatment of Pancreatic Cancer. | Pancreatic cancer is projected to become the second leading cause of cancer death by 2030 with a dismal 5-year survival rate compared to other cancers (12%). Due to the absence of clear early symptoms, diagnosis is often delayed resulting in many patients presenting with advanced disease and limited treatment options. ... |
41890658 | Multifunctional Nanoparticles in Traumatic Brain Injury: From Targeted Imaging and Diagnosis to Innovative Therapeutics. | Traumatic brain injury (TBI) remains a leading cause of morbidity and mortality worldwide, with limited therapeutic progress due to challenges such as impermeability of the blood-brain barrier (BBB) and the multifactorial nature of secondary neurodegeneration. Nanoparticle-based platforms, owing to their tunable physic... |
41884487 | Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition. | The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical me... |
41884479 | Comparison of the Effects of Glycopyrrolate and Atropine on Postoperative Delirium in Older Adult Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Trial. | <h4>Background</h4>Postoperative delirium (POD) is a common complication that hinders recovery in older patients. This study aimed to compare the effects of glycopyrrolate and atropine, used to counteract the peripheral effects of neostigmine, on POD incidence in older patients undergoing laparoscopic colorectal surger... |
41884283 | Boosting Radioimmunotherapy by Functionalized Self-Assembled EGCG Nanoparticles Enhances Antitumor Effect for FLASH-RT. | <h4>Background</h4>With the ability to achieve ideal efficacy while significantly reducing radiation damage to normal tissues, ultra-high dose rate radiotherapy (FLASH-RT) is considered one of the most innovative technologies for cancer treatment in the era of precision medicine. However, compared with conventional rad... |
41868307 | Silk fibroin hydrogel adhesive combined with miR-455 modified framework nucleic acids/ROS-responsive CeO<sub>2</sub> nanozymes for meniscus tears reconstruction. | The meniscus, a critical fibrocartilaginous structure in the knee joint that cushions load and stabilizes movement, suffers from poor self-healing potential following tears. This impaired repair not only fails to restore joint function but often progresses to osteoarthritis, posing significant clinical challenges. Regr... |
41831979 | Mapping the influence of solubility and spinnability of alginate in a ternary solvent system. | This study presents a scalable strategy for designing the morphology of polysaccharides for applications in food, biomedical fields, and additive manufacturing. An adjustable ternary supramolecular formulation framework consisting of ethanol, glycerol, and water, designed to steer pure sodium alginate (SA) electrohydro... |
41810070 | Plasma Activate Nitrogen for Efficient Ammonia Synthesis: Plasma Ammonia Synthesis. | Synthetic ammonia is of great significance to the development of industry and agriculture. At present, its manufacturing production is still dominated by century-old Haber-Bosch process, involving in huge amounts of energy consumptions and carbon dioxide emissions. Hence, it is of great significance to develop green an... |
41799044 | Crystal structure and Hirshfeld surface analysis of the coordination compound di-aqua-[5,10,15,20-tetra-kis-(4-chloro-phen-yl)porphyrinato-κ<sup>4</sup> <i>N</i>]magnesium(II). | During the synthesis of the (oxalato)[5,10,15,20-tetra-kis-(4-chlor-ophen-yl)porphyrinato]magnesium(II) ([Mg(TClPP)(ox)]) complex [TClPP = 5,10,15,20-tetra-kis-(4-chloro-phen-yl)porphyrinate and ox = oxalate], the title compound, [Mg(C<sub>44</sub>H<sub>24</sub>ClMgN<sub>4</sub>O<sub>2</sub>)(H<sub>2</sub>O)<sub>2</sub... |
41767267 | Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host. | Prolonged virus-host interaction and suboptimal immunity during persistent SARS-CoV-2 infection of immunocompromised patients enables viral adaptation. We investigated viral evolution and immune escape during a 2.5-year persistent infection in a patient with multiple myeloma and rheumatoid arthritis receiving anti-CD20... |
41755847 | Dynamic Covalent Platform for Chiroptically Tunable Figure-Eight Macrocycles from Preorganized Alkaloidal Scaffolds. | Chiral <i>D</i> <sub>2</sub>-symmetric figure-eight macrocycles with extended π-conjugated systems represent versatile scaffolds for developing advanced chiroptical materials. Here, we present a dynamic covalent platform that transforms a preorganized alkaloidal bispyrrolidinoindoline (BPI) scaffold into a series of ch... |
41755848 | Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis. | The pikromycin polyketide synthase (PKS) catalyzes formation of 12-membered macrolactone 10-deoxymethynolide, and 14-membered macrolactone narbonolide. Herein, we show the efficient diversification of novel 14-membered macrolactones and identification of 6-membered δ-lactones from a series of unnatural pentaketides usi... |
41754948 | Influence of Impregnation Conditions on Tenoxicam Solubility and Loading into γ-Cyclodextrin Metal-Organic Frameworks: A Box-Behnken Design Approach. | <b>Background/Objectives</b>: γ-Cyclodextrin metal-organic frameworks (γ-CD-MOFs) are biocompatible porous crystalline materials that combine the advantages of both γ-cyclodextrins (γ-CDs) and MOFs, making them promising carriers for drug delivery. However, drug loading efficiencies into γ-CD-MOFs achieved by impregnat... |
41743161 | Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex. | Conventional radiotherapy compromises antitumor immunity through collateral damage to immune cells. While boron neutron capture therapy (BNCT) enables tumor-selective <sup>10</sup>B (n, α) <sup>7</sup>Li reactions, clinical agents like boronophenylalanine (BPA) suffer from excessive dosing and exhibit immune-metabolic ... |
41745385 | The Role of Mucins in Esophageal Inflammatory Diseases. | Mucins are high-molecular-weight glycoproteins that form the main structural component of the mucus covering epithelial surfaces in the gastrointestinal, respiratory, and urogenital tracts. They support epithelial integrity by protecting against microbial invasion, dehydration, and mechanical or chemical insults, while... |
41745019 | A Comprehensive Review on Innovative Food Gelling Strategies for Sustainable Production of Meat Analogs and Restructured Meat. | The growing need for ecologically sound and ethical protein sources has contributed to the development of meat analogs (MAs) and restructured meat products (RMPs). Next generation MA and RMP production requires sustainable structuring techniques to imitate the physical, chemical, and sensory characteristics of conventi... |
41744721 | A Simple and Visual Colorimetric Aptasensor Based on AuNPs for the Rapid Detection of Sulfamethazine in Environmental Samples. | Sulfamethazine (SMZ) is widely used in livestock production, and its residues can enter water and soil environments, posing potential risks to human health and ecosystems. This study focuses on environmental samples and constructs an AuNP-based colorimetric aptasensor using the SMZ1S aptamer for the rapid visual detect... |
41738189 | Phosphorothioate Backbone Modification of Oligodeoxynucleotides Induces TLR9-Independent Lung Epithelial Antimicrobial Responses. | Pneumonias remain a leading cause of death worldwide. Seeking novel strategies to protect susceptible patients, we have reported that inhaled delivery of a diacylated lipopeptide and a synthetic CpG oligodeoxynucleotide (ODN) protects animals against a broad range of infectious pneumonias by stimulating antimicrobial r... |
41732391 | Engineered catechol-based composite materials for diabetic wound healing. | Diabetic wound healing impairment represents a major global clinical challenge and conventional therapies often target a single aspect, failing to coordinately regulate this complex pathological network. In recent years, naturally derived catechol/polyphenolic compounds (e.g., tannic acid, dopamine, epigallocatechin ga... |
41732174 | Phylogenetic analysis reveals diversity in glycan biosynthesis in "<i>Candidatus</i> Accumulibacter". | Although biofilms are widespread in nature, the ecological roles and compositional diversity of the extracellular polymeric substances (EPS) forming these structures remain poorly understood. Here, we apply a bottom-up genomic approach by investigating the biosynthetic potential for glycan precursors in the genus "<i>C... |
41728615 | Comparison of the efficacy of platelet-rich plasma versus corticosteroid in the treatment of adhesive capsulitis: a systematic review and meta-analysis based on randomized controlled trials. | <h4>Background</h4>Adhesive capsulitis (AC) often impairs patients' quality of life due to shoulder pain and restricted joint mobility. Intra-articular shoulder injection is a profound conservative treatment modality. Existing randomized controlled trials (RCTs) have reported conflicting results regarding the efficacy ... |
41727667 | The role of antibody-drug conjugates in the treatment of lung cancer. | Over the las0t decades, lung cancer treatment has improved immensely, mainly due to the incorporation of new targeted treatments and immunotherapy. A relatively new and potentially highly effective class of drugs, antibody-drug conjugates (ADCs), has been introduced to the clinical setting and is currently under intens... |
41727502 | Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8<sup>+</sup>T cell infiltration mediated by Rela/NF-kB-Cxcl9 axis. | <h4>Background</h4>Emotional distress (ED) is closely associated with the progression of triple-negative breast cancer (TNBC). Xiaoyao San (XYS), a classical Chinese herbal prescription traditionally used for mood regulation, has demonstrated potential therapeutic efficacy in emotion-related breast cancer. However, the... |
41727505 | Targeting pyroptosis in periodontitis: mechanisms and therapeutic strategies. | Periodontitis is a common chronic inflammatory disease of the oral cavity. It is characterized by progressive destruction of the periodontal supporting tissues and alveolar bone loss, and it remains a leading cause of tooth loss in adults. In recent years, pyroptosis, a pro-inflammatory form of programmed cell death, h... |
41727479 | Dengue-SARS-CoV-2 interactions: immune crosstalk, variant emergence, and clinical outcomes. | This review aims to provide an overview of dengue-COVID-19 co-infection, emphasizing recently described immunological, genomic, and eco-epidemiological interactions that may influence clinical outcomes and viral evolution. It brings together molecular evidence, immunological perspectives, and epidemiological insights t... |
41727434 | Recombinant ROP8 antigen: diagnostics, immunogenicity, and therapeutic targeting in toxoplasmosis. | <h4>Introduction</h4><i>Toxoplasma gondii</i> invasion relies on the battery of specialized proteins, such as ROP8, which plays a key role in formation of parasitophorous vacuoles within host cells. The aim of the work was to evaluate diagnostic, immunoprophylactic and therapeutic potential of recombinant ROP8 (rROP8) ... |
41727429 | Immunoglobulin G N-glycosylation remodeling in viral infections: immunomodulatory roles and potential biomarker implications. | The glycosylation of Immunoglobulin G (IgG), a complex post-translational modification, is essential for the structure and function of IgG. The varying affinities of different IgG N-glycans for Fcγ receptors can influence inflammatory responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), complement... |
41727314 | Development of gold nanoparticles stabilized by PLGA and PVA for application in photothermal therapy. | <h4>Introduction</h4>In today's world, cancer remains a major public health problem. Consequently, there has been a focused investigation of alternative therapeutic approaches to address this ongoing health concern. In this study, PLGA-gold nanomaterials were produced through various processes to determine whether thes... |
41727276 | Prophylactic self-assembled nucleic acid hydrogel targeting retinal ganglion cell cuproptosis and microglial neuroinflammation for retinal ischemia-reperfusion injury. | Retinal ischemia-reperfusion (RIR) injury constitutes a common pathological pathway in glaucoma, diabetic retinopathy, and other neurodegenerative diseases, frequently leading to irreversible neuronal loss. This study identifies concurrent FDX1-dependent retinal ganglion cell (RGC) cuproptosis and MyD88-mediated microg... |
41726638 | DFT Investigation of PFOS Interaction with 4H-SiC: A Feasibility Study for Environmental Sensing Applications. | Perfluorooctanesulfonic acid (PFOS) is a persistent and toxic compound frequently detected in contaminated soil and groundwater. In this study, we employ density functional theory (DFT) to evaluate the potential of 4H-SiC, a low-cost, environmentally safe, and stable semiconductor, as a candidate sensing material for P... |
41726619 | By Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies. | Furosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient... |
41725956 | Application of nanoparticles in antibody drug delivery. | Due to their special molecular weight and pharmacokinetic/pharmacodynamic (PK/PD) characteristics, antibody drugs have difficulty crossing the body barrier and entering complex microenvironments to provide effective treatment for encephalopathy, cancer, and severe infectious diseases. With the development and applicati... |
41725959 | Synergistic photothermal therapy of esophageal cancer using Pt@MOF@PSs nanozymes. | Globally, esophageal cancer (EC) is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer-related death. However, its treatment remains challenging due to significant obstacles. Photothermal therapy (PTT), a minimally invasive technique, has emerged as a promising method for tumor ablation. H... |
41718270 | Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives. | The central mechanistic hypothesis underlying multifactorial hearing loss posits that genetic susceptibility and environmental exposures act synergistically to disrupt cochlear homeostasis through redox imbalance, mitochondrial dysfunction, and pro-inflammatory mechanisms. This gene-environment paradigm has significant... |
41718120 | Breaking Barriers: Advancements in CNS Drug Delivery for Glioblastoma. | Glioblastoma is known as the most aggressive primary brain tumor in adults, and it is still largely not curable, with a median survival of approximately 15 months when standard multimodal therapy is applied. The standard treatment nowadays is maximal safe surgical resection, associated with radiotherapy and temozolomid... |
41717357 | <i>KIR AA</i> individuals possess strong inhibitory <i>KIR</i> alleles alongside HLA ligands that are protective against leukemia in the Chinese population. | <h4>Introduction</h4>The killer-cell immunoglobulin-like receptor (<i>KIR</i>) gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism. To date, 2,286 distinct <i>KIR</i> alleles have been released in the IPD-KIR Database. However, little is known about th... |
41716337 | <i>In situ</i> self-assembling rebamipide-based eye drops to promote secretion of mucin for treatment of dry eye. | Rebamipide is effective for dry eye management, but its insolubility limits formulation development. An optimal design is crucial for patient comfort and maximizing bioavailability. Here we covalently conjugate rebamipide with a peptide motif (FFFYpEH) to generate a peptide-drug conjugate that dramatically improves sol... |
41716340 | The enhanced photothermal therapy against gastric cancer by mitochondria/STAT3-targeted nanoplatform with OXPHOS blocking. | Near-infrared (NIR) photothermal therapy (PTT) has provided an innovative modality for the ablation of gastric cancer (GC) with minimized damage to normal tissues. However, the upregulation of heat shock proteins (HSPs) and the abnormal vascularization at the tumor site, as well as the low specificity with the diffusio... |
41716334 | Nanomedicine-based lactate metabolism and lactylation regulation for exploring new therapeutic strategies in cancer. | Lactate, a key metabolite of glycolysis in tumor cells, plays a dual role in cancer progression. On one hand, it contributes to the formation of an acidic tumor microenvironment that fosters tumorigenesis and malignancy. On the other, it promotes tumor progression through protein lactylation, a recently identified post... |
41708241 | Classification of DNA secondary structures by combining multiple spectral techniques with machine learning. | <h4>Background</h4>The identification of structural features is an essential prerequisite for the determination of DNA secondary structures and investigating structural formation mechanisms. Circular dichroism (CD) spectroscopy, fluorescence (FL) spectroscopy, and thermal difference spectra (TDS) have already been used... |
41705137 | Brain-targeted delivery of siRNA via non-viral delivery systems, the therapeutic strategy for Alzheimer's disease-Unveiling challenges and prospects. | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral issues, posing significant public health challenges. Small interfering RNAs (siRNAs) offer the potential to selectively silence AD-related pathogenic genes. This review first outlines the diverse pathogenic mechanisms and... |
41704592 | Integrated transcriptomic and metabolomic profiling deciphers breed-, age-, and rearing system-dependent regulation of muscle development and meat quality in chickens. | Chicken is an important source of protein worldwide, and its quality is influenced by breed, age, and rearing methods. However, how these factors interact at the metabolic level is not fully understood. This study examined Yandang partridge chickens, a native Chinese breed, and commercial Arbor Acres (AA) broilers unde... |
41696601 | Inverse design of frustrated Lewis pairs for direct catalytic CO<sub>2</sub> hydrogenation: refining and expanding design rules. | Frustrated Lewis pairs (FLPs), composed of reactive combinations of Lewis acids (LAs) and bases (LBs) offer a metal-free platform for catalyzing a wide range of chemical transformations. Designing the optimal FLP active site for a particular chemical reaction is a challenging task due to the lack of rigorous principles... |
41687284 | Lymph nodes-targeted nano-prodrug for precise B cell immunoregulation to prevent collagen-induced arthritis. | Rheumatoid arthritis (RA) is a systemic autoimmune disease marked by progressive joint destruction and deformities, which are irreversible once they develop. If the disease can be prevented in the preclinical stage, it may significantly reduce the rate of RA incidence and disability. However, insufficient attention has... |
41684011 | Nrf2-Activating Natural Compounds in Neurodegenerative Diseases: Targeting Oxidative Stress and Protein Aggregation. | Neurodegenerative diseases (NDs) are among the leading causes of disability and mortality worldwide and are characterized by multifactorial pathogenesis involving interconnected mechanisms, such as oxidative stress, protein misfolding and aggregation, neuroinflammation, and mitochondrial dysfunction. Dysregulation of t... |
41683995 | A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones from <i>Nepeta cataria</i> Leaves. | The reliance on synthetic repellents such as N,N-diethyl-meta-toluamide (DEET) has raised health and environmental concerns, prompting the search for safer, plant-based alternatives. Catnip (<i>Nepeta cataria</i> L.), a rich source of iridoid monoterpenes, particularly nepetalactones, known for strong insect-repellent ... |
41683997 | Photophysical Processes of Porphyrin and Corrin Complexes with Nickel and Palladium. | Nickel(II) and palladium(II) ions are capable of forming complexes with macrocyclic terapyrrole structures such as the porphyrin or corrin ring. Many different derivatives of these complexes are synthesized and studied because these compounds have potential numerous applications, including catalysis, various light-driv... |
41683986 | Recent Advances in Lanthanide Complexes in Biological Systems: Coordination Principles and Interactions with Biomolecules. | Lanthanide ions and their complexes have emerged as versatile tools in biology and medicine owing to their unique photophysical, magnetic, and coordination properties. Their applications span bioimaging, sensing, therapy and diagnostics, underpinned by their strong preference for oxygen-donor ligands, kinetic stability... |
41683983 | Peptide Nucleic Acids (PNAs) in Antimicrobial Therapy: A Next Generation Strategy. | The global rise in antimicrobial resistance (AMR) demands innovative strategies beyond traditional antibiotics. Peptide Nucleic Acids (PNAs), synthetic DNA analogues with peptide-like backbones, act as thermically, chemically, and enzymatically stable sequence-specific agents capable of silencing essential bacterial ge... |
41683536 | Enhancing Tumor Photodynamic Therapy via Molecular Engineering and Functional Modification of Photosensitizers. | Photosensitizers are susceptible to interference from the biological internal environment, which largely restricts the clinical application of photodynamic therapy. For instance, most existing photosensitizers tend to aggregate in the biological environment, resulting in a decrease in reactive oxygen species yield; the... |
41683531 | A UHPLC-Orbitrap-MS Metabolomics Strategy Reveals Glycerophospholipid Metabolic Remodeling Is Associated with the Anti-Arthritic Effect of Glycyrrhiza Protein-Paeoniflorin Nanoparticles via PI3K/AKT/NLRP3 Axis. | Rheumatoid arthritis involves chronic synovitis and immune-metabolic dysregulation, highlighting a need for multi-target therapies that jointly modulate metabolism and inflammation. We developed glycyrrhiza protein-paeoniflorin self-assembled nanoparticles (GP-PF NPs) and investigated their anti-arthritic mechanism in ... |
41683540 | Effect of <i>n</i>-Octadecylphosphonic Acid Coating on Zeolite 5A for Adsorptive Separation of Carbon Dioxide and Propylene. | Understanding the competitive adsorption mechanism is crucial for the rational design of CO<sub>2</sub> adsorbents. In this work, the surface of zeolite 5A was modified with varying concentrations of <i>n</i>-octadecylphosphonic acid (ODPA) to enhance the adsorptive separation of CO<sub>2</sub> over C<sub>3</sub>H<sub>... |
41683158 | Balancing Functionality and Safety in Food Packaging Coatings. | Functional coatings for food packaging offer innovative approaches to extend shelf life, preserve quality and introduce active properties such as antimicrobial or antioxidant effects. These coatings include natural bio-based films (e.g., polysaccharide or protein-based) and synthetic polymers enhanced with additives or... |
41683151 | Exploration of Natural Protein-Polysaccharide-Polyphenol Ternary Complexes from Grape Pomace for Clean-Label Pickering Emulsions Through pH Adjustment. | Grape pomace represents a major organic solid waste generated by the wine industry, but its application has been largely unexplored. On the other hand, so far, stable and sustainable raw materials for producing stable, edible Pickering emulsifiers suitable for the food industry have been lacking. To solve these problem... |
41682120 | Structural and Functional Modifications of Hazelnut Proteins Induced by Atmospheric Cold Plasma. | This study evaluated the effects of atmospheric cold plasma (ACP) treatment duration on the physicochemical and functional properties of hazelnut protein. Proteins were extracted from defatted hazelnut flour and subjected to ACP for 0, 2, 4, 6, and 8 min. The results demonstrated that ACP treatment significantly modifi... |
41681492 | Collagen-Based 3D Scaffolds from Sea Urchin Food Waste for Skeletal Muscle Tissue Engineering. | Preclinical investigations involving in vivo animal studies, are considered a crucial and mandatory step in pharmacological industry regulations. In recent years, as the ethical concerns associated with animal experimentation are becoming more relevant, substantial research efforts have been directed towards the develo... |
41679004 | Anthelmintic effects of Artemisia herba-alba and Artemisia judaica extracts on Ascaridia galli in poultry. | Assessment of antiparasitic efficacy of Artemisia herba-alba and Artemisia judaica using in vitro, in silico, and animal-based models against Ascaridia galli was conducted. Ethanolic extracts from each Artemisia species were separately prepared in 0.5% DMSO. For the in vitro analysis, a total of 180 adult Ascaridia gal... |
41677664 | Form Meets Function: Fiber Architecture Directs Proliferation and Differentiation in Gingival Keratinocytes. | Precise control of keratinocyte proliferation and differentiation is critical for oral epithelial regeneration, yet the mechanobiological cues guiding these processes remain incompletely defined. Here, we systematically evaluated how electrospun polycaprolactone (PCL) scaffolds with defined fiber orientations (aligned ... |
41677661 | mRNA Vaccines in Melanoma Immunotherapy-A Narrative Review. | Melanoma is one of the most aggressive forms of cancer and the leading cause of death related to skin disease. Recent years have seen a significant increase in the number of cases of this type of cancer, underscoring the need to develop effective therapeutic strategies to control it. One of the most promising research ... |
41675994 | On-Column Dual-Gradient Refolding for Efficient Recovery of Insoluble Affinity-Tagged Recombinant Proteins. | This article presents an efficient protocol for refolding recombinant proteins that are prone to aggregation and form inclusion bodies during expression in <i>Escherichia coli.</i> As a model system, the homolog of CRISPR-associated effector protein CasV-M was investigated. The key element of the developed approach is ... |
41671788 | Advanced processes for engineering food protein amyloid fibrils: Molecular mechanisms, processing parameters, and structure-function relationships. | Amyloid fibrils derived from food proteins (PAFs) represent highly ordered supramolecular assemblies with distinctive β-sheet-rich architectures, exceptional mechanical robustness, and remarkable environmental stability. These nano-structured materials have emerged as promising bio-derived platforms for engineering sus... |
41660633 | Biodegradable, Thermally Stable, and Programmable Cellulosic Bioplastics Enabled by Supramolecular Stimulated Mediation. | Bioplastics derived from renewable food crops or agricultural feedstocks are alternatives to petrochemical materials, but it is challenging to balance their mechanical properties, thermal stability, and shapeability. Here, we report a thermally stimulated supramolecular bioplastic that employs polyethylene glycol to op... |
41660304 | Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets. | Bone metastasis (BoMet) is a common complication in various cancers. Approximately 20-30% of patients with cancer develop BoMet, which is most frequently associated with solid tumors, such as breast, prostate, and lung cancers. BoMet can lead to skeletal-related events such as fractures, bone pain, and hypercalcemia, n... |
41660305 | Progress in RNA-Targeted Therapeutics for Human Diseases. | RNA-targeted therapy is reshaping molecular medicine by shifting the traditional "protein-centric" view toward an "RNA-regulatory network" paradigm. Beyond carrying genetic information, RNA plays essential roles in posttranscriptional regulation, signaling pathways, and epigenetic modulation. Advances in high-throughpu... |
41658413 | Multimodal characterization of a pyrazolo[3,4-<i>b</i>]pyridine aldehyde: quantum chemical insights, NLO activity and VEGFR-2 docking/molecular dynamics. | The aldehyde-functionalized pyrazolo[3,4-<i>b</i>]pyridine derivative CJ129 was examined in the solid state for the first time using single-crystal X-ray diffraction. The analysis showed that the molecule adopts a monoclinic <i>P</i>2<sub>1</sub>/<i>c</i> arrangement, in which the packing is supported by π-π stacking i... |
41658408 | Hydrogel-based drug delivery systems for enhanced tumor therapy. | Cancer remains a major global health challenge, with current treatment modalities like surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy often hampered by limitations such as systemic toxicity, drug resistance, and an immuno-suppressive tumor microenvironment (TME). Hydrogel technology emerges as... |
41657532 | Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health. | The gut microbiota is essential for colonic health, and its imbalance (dysbiosis) is linked to conditions like inflammatory bowel disease and metabolic disorders. Whey proteins (WPs), including β-lactoglobulin, α-lactalbumin, glycomacropeptide, and lactoferrin, possess antimicrobial, immunomodulatory, and prebiotic-lik... |
41654127 | HPV18E6 and CDK5 virus-host interaction is a prospective therapeutic target for HPV-positive cervical cancer. | The E6 oncoprotein encoded by the cancer-causing human papillomavirus (HPV) is vital for maintaining the ability of the virus to promote cell proliferation and cancer progression. This study identified that cyclin-dependent kinase 5 (CDK5) is a previously unidentified host target of E6 encoded by cancer-causing HPV gen... |
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