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41654055 | Chitosan coating functionalized with silver nanoparticles synthesized from avocado leaves and cinnamon oil/β-cyclodextrin: An eco-friendly approach to avocado preservation. | This study evaluated the synergistic efficacy of silver nanoparticles (AgNPs) and cinnamon oil, with criteria based on reducing minimum effective concentrations while maintaining or enhancing antifungal activity compared to individual treatments. The antifungal effects of AgNPs and the cinnamon oil/β-cyclodextrin compl... |
41651428 | Cell entry mechanisms of porcine enteric coronaviruses. | Porcine enteric coronaviruses, including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and porcine deltacoronavirus (PDCoV), cause severe watery diarrhea, vomiting, dehydration, and high mortality in piglets, leading to enormous... |
41651078 | Long-term clinical outcomes of 0.015 % tacrolimus HPβCD eye drops in ocular surface inflammatory disorders. | <h4>Background</h4>Topical tacrolimus offers potent anti-inflammatory effects across a spectrum of ocular surface diseases, but its ophthalmic use has been limited by formulation challenges. This study evaluated 0.015 % tacrolimus/hydroxypropyl-β-cyclodextrin eye drops (TCD) long-term performance.<h4>Methods</h4>In a p... |
41650952 | Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors. | Chimeric antigen receptor (CAR) cell therapy transforms hematologic cancer treatment but remains limited in solid tumors due to stromal barriers and an immunosuppressive tumor microenvironment that restricts immune cell infiltration. To address these barriers, we develop a cell-free therapeutic platform based on CAR-en... |
41645660 | Donor-Acceptor Engineering Enables Kinetic Control of Chirality Transfer in Side Chain Polymers. | Chirality transfer across hierarchical architectures represents a pivotal and underexplored challenge in the design of functional chiral materials. Through molecular engineering integrating chiral α-terminal groups with electronically tunable azobenzene (Azo) side chains, we demonstrate that in kinetically trapped aggr... |
41645662 | Modular Assembly of Dynamic Polymer Networks From Heteroaffinity Cross-Links to Multivalent Proteins. | Dynamic polymer networks (DPN) leverage transient cross-linking to yield macroscopic materials that exhibit self-healing and environmentally responsive behaviors. Despite the broad scope of chemical interactions available for cross-linking, imbuing those transient interactions into biologically compatible materials is ... |
41645634 | High-Performance, Recyclable Thermosets Enabled by Thiosemicarbazone Dynamic Bonds via Synergistic Dynamic Covalent and Supramolecular Networks. | Recyclable thermosets have emerged as promising candidates to mitigate plastic pollution, yet reconciling high performance with efficient recyclability remains challenging. Here, we report a high-performance, readily recyclable thermoset engineered through a synergistic dynamic covalent and supramolecular network. This... |
41645637 | PLA/gelatin/ethyl cellulose nanofiber: performance optimization and strawberry preservation. | <h4>Background</h4>As the demand for eco-friendly food packaging rises, biodegradable electrospun fiber membranes have attracted wide attention. However, existing single-component membranes face limitations such as insufficient mechanical properties, unstable functional release, and weak antioxidant/antibacterial activ... |
41645631 | Advanced Eco-Friendly Applications of Metal-Organic Frameworks: From Pollution Control to Energy and Health Technologies. | Metal-organic frameworks (MOFs), owing to their highly tunable structures, large specific surface areas, rich pore architectures, and diverse functionalities, have emerged as promising candidates for addressing environmental and energy challenges. With continuous advances in green synthesis techniques, eco-friendly app... |
41645535 | Pd-Catalyzed Aqueous Buchwald-Hartwig Amination with Amphiphilic Polymer PEG-PVEG. | An efficient micellar palladium-catalyzed aqueous Buchwald-Hartwig amination has been developed, enabled by the self-assembly of amphiphilic copolymer polyethylene glycol-polyvinylethylene glycol (PEG-PVEG). Using 0.5 mol % BrettPhos-Pd-G3 as a catalyst, the aqueous amination showed broad a substrate scope, including a... |
41645445 | Visualizing Interfacial Charge Trapping in a Heterostructure of a Monolayer Metal-Organic Framework on a van der Waals Substrate. | Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have garnered significant attention for their potential applications in energy devices such as supercapacitors and batteries due to their high electrical conductivity and large surface area. In this study, we synthesize a single-layer 2D c-MOF, Ni<sub>3</s... |
41645265 | Targeted repair of oral mucosal injury: emerging applications of biomaterials-based drug delivery systems. | The oral mucosa, as an important barrier to external exposure, is susceptible to damage caused by various factors, leading to a series of clinical symptoms. Traditional treatment methods have problems such as short drug retention time and unstable local exposure, which make it difficult to meet the treatment needs of o... |
41645252 | Beyond CRISPR: next-gen precision engineering of CAR-NK cells for enhanced persistence, trafficking, and tumor eradication. | Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising "off-the-shelf" alternative to CAR-T cells, offering a superior safety profile and inherent multi-antigen targeting capabilities. However, their clinical potential is constrained by the "CRISPR ceiling", a set of practical limitations of DSB-... |
41645230 | Synthesis, structural characterization, DFT calculation, and antitumor activity of a new Co(II) complex based on 2-((2'-Carboxybenzyl)oxy)benzoic acid and 2,2'-bipyridine ligands. | In this work, a new Co(II) complex, abbreviated as [Co(L)(bipy)(H<sub>2</sub>O)<sub>2</sub>]<sub>n</sub> (1) was prepared using cobalt(II) acetate tetrahydrate, 2-((2'-carboxybenzyl)oxy)benzoic acid (H<sub>2</sub>L), and 2,2'-bipyridine (bipy) ligands in a mixture solution of ethanol and water (v: v = 3: 1). The struct... |
41645206 | Mitochondrial protein-enriched artificial nanovesicles: mitochondrial recovery and antioxidation for diabetic wound treatment. | Oxidative stress and mitochondrial dysfunction are major barriers to the healing of diabetic wounds (DW). Eliminating reactive oxygen species (ROS) and restoring mitochondrial function are considered effective strategies to accelerate DW healing. Although extracellular vesicles (EVs) derived from mesenchymal stem cells... |
41645189 | Conductive MXene/adECM hydrogel promotes skeletal muscle regeneration and innervation through Ca<sup>2+</sup> influx modulation and neuromuscular junction formation. | <h4>Background</h4>Volumetric muscle loss (VML) leads to severe skeletal muscle dysfunction. While muscle tissue engineering offers a promising strategy, challenges persist due to insufficient neuromuscular innervation and poor reconstruction of neuromuscular junctions (NMJs). Conductive hydrogels can mimic the electro... |
41645084 | MARVpred: machine learning prediction of inhibitors targeting Marburg virus Gene 4 Small ORF protein. | The Marburg virus (MARV), responsible for severe hemorrhagic fevers with mortality rates as high as 90%, remains a significant public health threat. This study employs machine learning to identify inhibitors targeting the MARV Gene 4 Small ORF protein, crucial for the virus's replication and immune evasion. The Gene 4 ... |
41644999 | Aniracetam restores the excitation-inhibition balance of neurotransmitters in the prefrontal cortex of mice with ADHD. | Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder in childhood and a common chronic condition among school-aged children. However, the pharmacological mechanisms and pathophysiology of ADHD remain incompletely elucidated. Transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazo... |
41644952 | Continuously tunable multistability in DNA replication networks. | Multistable systems, ideally, could stabilize at any desired, switchable state within a continuous spectrum. However, conventional systems, constrained by signal-mediated mutual activation or inhibition, are limited to a finite set of discrete steady states. Here, we propose a rational framework for achieving continuou... |
41644942 | Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcoma. | Osteosarcoma (OS) is the most common primary malignant bone tumor mainly affecting children and young adults. Despite current treatments combining polychemotherapy and surgery, survival rates have remained unchanged for decades, highlighting the need to identify novel therapeutic approaches. NXP800, a newly developed o... |
41644940 | Axially engineered single atoms in enzyme-mimic-binding pocket steering dehalogenation-polymerization pathways toward water pollutant upcycling. | Polymerization-based advanced oxidation processes (P-AOPs) represent a promising strategy for simultaneous pollutant abatement and water resource recovery. However, selective removal of halogenated organic pollutants via P-AOP remains challenging due to uncontrollable oligomerization pathways and radical chain inhibiti... |
41644848 | A pharmacological modality to sequester homomeric proteins. | Molecules that facilitate protein-protein interactions are immensely impactful. However, such compounds typically rely on accessory proteins to function, such as E3 ligases for targeted degradation, which may restrict their scope or lead to resistance. We alleviate the need for accessory proteins with a strategy that e... |
41644759 | Azobenzene-bridged ionizable amphiphilic Janus glycosides for light-controlled, single-component and organ-modulable pDNA delivery. | Stimuli-responsive supramolecular systems enable spatiotemporal control of nucleic acid (NA) delivery. To achieve precise and programmable vectors, we designed azobenzene-bridged ionizable amphiphilic Janus glycosides (IAJGs) as single-component, light-responsive DNA carriers. These glucopyranose-based dimers undergo r... |
41644548 | Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex. | Capsular polysaccharides (CPS) are key virulence determinants, constituting the protective capsule that surrounds bacterial pathogens. Here, we present the complete cryo-EM structure of Gram-negative bacterial CPS secretion machinery formed by the E. coli K12 Wza-Wzc complex. The structure reveals an elongated, continu... |
41644540 | Atomic resolution ensembles of intrinsically disordered proteins with Alphafold. | Intrinsically disordered proteins are ubiquitous in biological systems and play essential roles in a wide range of biological processes and diseases. Despite recent advances in high-resolution structural biology techniques and breakthroughs in deep learning-based protein structure prediction, accurately determining str... |
41644524 | Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies. | Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges, primarily due to its propensity for developing resistance to therapeutic interventions. While the underlying mechanisms remain elusive, they are closely associated with mitochondrial adaptation in response to treatment. Mitophagy, a sele... |
41644527 | From waste rubber to value polybutadiene modification for circular materials. | Synthetic rubber waste poses a growing environmental challenge due to its cross-linked, non-recyclable nature. This Perspective examines emerging post-polymerization modification strategies for linear polybutadiene and vulcanized rubber, spanning catalytic, metal-free, and catalyst-free approaches, and evaluates their ... |
41644522 | Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes. | The exact biological role of mitochondrial supercomplexes remains debated, particularly their role in guiding redox proteins across membranes during energy conversion. We integrate multiscale modeling and single particle cryo-electron microscopy (cryo-EM) to examine electron transfer in mitochondrial supercomplexes com... |
41644526 | Sequential-chain coupling over hierarchical click-sites enables highly selective urea electrosynthesis. | Electrochemical C - N coupling is an appealing approach for sustainable urea synthesis, while it is technically challenging due to the complex reaction mechanism and the spatiotemporal mismatch between C- and N- intermediates. Here, inspired by click chemistry, we design a hierarchical click-site catalyst (Se-InO<sub>x... |
41644471 | Solid-Phase Molecular Self-Assembly Leading to Scale-Span Molecular Materials. | Scale-span molecular self-assembly is a long-standing challenge in the field of molecular self-assembly, which has been proven to be almost impossible in solution. Yet recent studies show that it may occur in the solid phase driven by interfacial energy, and macroscopic bulk materials with ordered molecular arrangement... |
41643127 | Advancing Porous Carbons: Understanding the Importance of Surface Chemistry for the Energy-Environment Nexus. | This review intends, in a critical way, the comprehensive view of the importance of porous carbons surface chemistry for their applications in an energy-environment nexus. Surface chemistry is presented as a combination of functional heteroatom-containing groups, dopants, and structural defects. First, we briefly addre... |
41643069 | Carbenes Embedded in Cyclic Paraphenylenes: Detection, Ground-State Spin Multiplicity, and Möbius Aromaticity. | Carbenes are divalent carbon species that have attracted significant research interest due to their ability to form two new bonds and their potential applications as ligands in catalysis and in the development of magnetic materials. In this study, we report singlet ground-state diarylcarbenes, embedded within a unique ... |
41643057 | Empowering Carbon Fibers With Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene: A Paradigm Shift Toward Integrated Structure-Function Composites. | This review delineates a transformative strategy in advanced materials: the integration of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene with carbon fibers (CFs) to forge a new class of multifunctional structural composites. This integration strategy signifies a paradigm shift from simple structural components to mult... |
41643020 | Patchy peptide particles for pH-responsive assembly into liquid crystals or lattices. | Programmable control of protein or colloidal nanoparticle self-assembly into targeted nanostructures, while maintaining stability across extreme pH conditions, remains a major challenge. We designed coiled-coil bundlemer peptide nanoparticles that form ordered, hierarchical materials across an unusually broad pH range ... |
41642996 | Gapless pangenome analyses reveal fast <i>Brassica rapa</i> subspeciation. | <i>Brassica rapa</i> (<i>Br</i>) encompasses many morphotypes and subspecies, so it is a good model with which to investigate plant diversification and subspeciation. Here, we resequenced the genomes of 1720 <i>Br</i> accessions and de novo assembled 11 representative telomere-to-telomere gapless genomes for seven elit... |
41642934 | Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities. | The receptor-binding protein of influenza A virus, hemagglutinin (HA), is the most abundant protein on the viral surface. While high densities of HA are thought to improve cellular attachment by increasing avidity for the viral receptor, they may also increase the avidity of neutralizing antibodies. The tradeoff betwee... |
41642921 | Isolation and characterization of broadly-neutralizing anti-HCMV-gB antibodies from human donors using a prefusion-stabilized HCMV gB variant. | Human cytomegalovirus (HCMV) poses a significant risk to immunocompromised individuals and is the leading cause of congenital birth defects worldwide. There is no cure or robust treatment options, although neutralizing antibodies (nAbs) derived from patient sera are being explored as prophylactics with limited success.... |
41642933 | A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation. | Lysophagy plays a key role in maintaining autophagy homeostasis, but the induction and regulation mechanisms of lysophagy are not clear. In this study, we found that Senecavirus A (SVA) dramatically decreased lysosomal-associated membrane protein 1(LAMP1), significantly increased lysosomal permeability, and induced lys... |
41642874 | The prognostic value of thromboelastography MA/R ratio in predicting mortality in acute respiratory failure patients. | Thromboelastography (TEG) MA/R ratio reflects coagulation status and thrombus strength. This study evaluated its prognostic value in acute respiratory failure (ARF). A retrospective analysis of 371 ARF patients admitted to the ICU, stratified by MA/R quartiles. Outcomes included 28-day mortality, deep vein thrombosis (... |
41642880 | Photodetachment Thresholds of Deprotonated Chlorophyll Pigments and Structural Characterization of Their Deprotomers. | Chlorophyll pigments and derivatives were studied under isolated conditions and at low temperatures in their anionic deprotonated form. Neutral and deprotonated chlorophyll pigments are isoelectronic, which likens their electronic properties, as is confirmed by electronic structure calculations. The study of these anio... |
41642819 | High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification. | Diversity-Generating Retroelements (DGRs) are specialized genetic systems typically harnessed in nature to evolve new molecular recognition. This mechanism, known as mutagenic retrohoming, relies on an error-prone reverse transcriptase (bRT) that introduces errors at template adenines, followed by the incorporation of ... |
41642647 | Shedding Light on the Capabilities of Heteroditopic Mechanically Interlocked Molecules in Ion-Pair Sensing. | Heterotopic mechanically interlocked molecules contain different binding sites within their structure, allowing them to recognize specific ion pairs (cations and anions) with a high affinity. The employment of heteroditopic receptors offers advantages over monotopic analogues, in general, being composed of both cation ... |
41642685 | Turn-On Terbium(III) Photoluminescence Enables Sensing of Methyl Salicylate by a Biomimetic Airborne Messenger Mechanism. | A low cost, portable optical sensing platform enables rapid and sensitive detection of methyl salicylate (<b>MeSal</b>) in unprocessed samples. The sensing assay is based on a strong photoluminogenic response when <b>MeSal</b> forms a complex with a terbium cation (Tb<sup>3+</sup>) in aqueous buffer. The assay employs ... |
41642594 | General-Purpose Models for the Chemical Sciences: LLMs and Beyond. | Data-driven techniques have a large potential to transform and accelerate the chemical sciences. However, chemical sciences also pose the unique challenge of very diverse, small, fuzzy data sets that are difficult to leverage in conventional machine learning approaches. A new class of models, which can be summarized un... |
41642587 | Anode-Free Batteries: Pioneering Energy Storage Revolution. | Anode-free batteries (AFBs) represent a transformative approach in energy storage technologies, eliminating the anode to achieve remarkable improvements in energy density, safety, and manufacturing simplicity. This review provides a comprehensive analysis of the fundamental phenomena governing the operation of AFBs dur... |
41642452 | Mechanistic insights into PVC microplastic adsorption on montmorillonite: A first-principles approach toward pollution control. | Plastic pollution has emerged as a pervasive environmental threat, with polyvinyl chloride (PVC) being a persistent polymer that can degrade into smaller fragments. These particles contaminate aquatic environments, accumulate in biota, and pose serious ecological and health risks. This study used computational methods ... |
41642342 | Supramolecular solvents based on deep eutectic solvents and hexafluorobutanol for the extraction of aristolochic acids from natural plants. | In this study, a new liquid phase microextraction method was developed by combining micelle-mediated extraction of aristolochic acids (AAs) in traditional Chinese medicines with polyfluorinated alcohol solutions, and subsequent preconcentration via deep eutectic solvent (DES)-induced supramolecular solvent (SUPRAS) for... |
41642334 | Optical Tweezers in Emulsion Research: Principles, Advances, and Prospects. | Optical tweezers (OTs) have emerged as a powerful tool for probing emulsion dynamics with single-droplet precision, enabling quantitative analysis of interfacial interactions. Recent OT studies have systematically elucidated the critical factors governing emulsion stability, including ionic strength, pH, surfactant arc... |
41642241 | Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions. | Oral insulin delivery represents a transformative approach to diabetes management, offering improved patient compliance and physiological insulin delivery patterns compared to subcutaneous injection. However, multiple gastrointestinal barriers, including enzymatic degradation, mucus entrapment, epithelial impermeabilit... |
41642253 | Structures of Photosynthetic Supramolecular Complexes. | Photosynthesis, the biological process of converting light energy into chemical energy, involves light harvesting, charge separation and electron transport, proton translocation, ATP synthesis, and carbon fixation, among other processes. Adjacent photosynthetic complexes may assemble into supramolecular complexes to co... |
41642127 | Supramolecular Templating of 3D Metal Halide Perovskites into Noncentrosymmetric Hybrids with High Nonlinear Optical Responses. | Lead-based halide perovskites have demonstrated remarkable success in applications such as photovoltaics, photodetectors, and LEDs, owing to their defect tolerance and exceptional optical and electrical properties. However, the major issue of lead toxicity has drawn considerable attention, requiring an appropriate solu... |
41642130 | Observation of Photophysical Processes of a Heptacene Derivative: Monomeric Behavior in Homogeneous Solution and Singlet Fission in Thin Film. | A soluble heptacene derivative, 5,9,14,18-tetrakis(triisopropylsilylethynyl)-heptacene (<b>TIPS-Hep</b>), was synthesized in situ from an α-diketone precursor via the Strating-Zwanenburg reaction, and its photophysical properties were comprehensively characterized in both solution and thin-film states. In deoxygenated ... |
41642009 | New hypothesis: a gut-lipid-kidney axis in constipated CKD patients-insights from multi-omics triangulation. | Patients with chronic kidney disease (CKD) frequently experience constipation, often linked to gut microbiota disruptions. We hypothesized that constipation is not merely a comorbidity but a driver of adverse outcomes through a specific host-microbial metabolic axis. Employing a multi-cohort design for evidence triangu... |
41641970 | The Osteoporotic Fractures in Men Study (MrOS): a 25-year landmark study of skeletal health in older men. | The Osteoporotic Fractures in Men study (MrOS) is amongst the largest and longest running prospective cohort studies of older men. MrOS determined how fracture risk was related to bone mass, bone geometry, lifestyle, anthropometric and neuromuscular measures, comorbidity, biomarkers, and fall propensity. The cohort con... |
41641936 | STAR Therapy: Spatiotemporal Antitumor Regimen via a Size-Gated DNA Hydrogel Drug Delivery System. | Current cancer therapies for solid tumors are significantly hampered by the dense tumor extracellular matrix (ECM), which restricts antitumor drug penetration and accumulation. Hence, there is a critical need for controllable drug delivery systems capable of spatiotemporally controlling the sequential action of ECM-mod... |
41641874 | Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non-Canonical Amino Acids. | Natural spider silk fibers are recognized for their outstanding mechanical properties. The production of underlying recombinant spider silk proteins in scalable quantities unlocks their potential for technical and biomedical applications. The recombinant spider silk technology further enables the introduction of new fu... |
41641873 | Efficient Prediction of Multicomponent Adsorption Isotherms and Enthalpies of Adsorption in MOFs Using Classical Density Functional Theory. | We demonstrate that classical density functional theory (DFT) based on the PC-SAFT equation of state is a fast, accurate, and predictive model to predict multicomponent adsorption in porous materials, which is an essential step toward the design of next-generation adsorbents for relevant applications. Using GPU acceler... |
41641870 | Beyond Excimer: Engineering Pyrene Stacking With Mechanical Bonds for Tunable Emissions. | Aiming to deepen the fundamental understanding of how hierarchical molecular packing governs the overall photophysical properties in multi-chromophore systems, engineering pyrene stacking with mechanical bonds has been successfully realized, leading to the construction of a novel family of pyrene-functionalized [1]rota... |
41641828 | Natural Compound-Driven Nano-Self-Assembly for Multimechanistic Transdermal Antiobesity Therapy. | Obesity is a complex metabolic disorder characterized by excessive fat accumulation and chronic, low-grade inflammation, contributing to a range of associated diseases. Conventional treatments are often limited by poor targeting, low efficacy, and undesirable side effects. Natural compounds with anti-inflammatory and m... |
41641799 | Edge-Enriched Metal-Organic Framework Integrated with a Gate-Sensitive Field-Effect Transistor for Highly Sensitive and Ultrafast Detection of Breath Acetone. | Non-invasive monitoring of exhaled acetone-a recognized biomarker of diabetes-has offered a promising and convenient diagnostic approach for diabetes. However, conventional optical and metal oxide semiconductor sensors suffer from bulky instrumentation, high power consumption, and poor portability. Metal-organic framew... |
41640363 | Supramolecular Ion-Channel Engineering of Spin-Charge Coexistence in a [Ni(dmit)<sub>2</sub>] Conductor Hosting Mixed-Valence Mn Cations. | The interplay between electrical conduction and magnetism offers a powerful means to elucidate emergent mechanisms and control properties; however, realizing this in Ni(dmit)<sub>2</sub> crystals has been challenging due to undesirable reactions among their components. Mn<sub>1.83</sub>([18]crown-6)<sub>3</sub>[Ni(dmit... |
41640357 | Constant-pH Molecular Dynamics of Cationic Peptide Dendrimers Binding to siRNA. | Transfection, the process of delivering genetic material into eukaryotic cells, is crucial in biotechnology and the development of treatments. Naked nucleic acids face challenges such as enzymatic degradation, poor pharmacokinetics, and immunogenicity, which can be mitigated by delivery systems such as liposomes, catio... |
41640332 | Supramolecular Assemblies of Self-Immolative Janus Dendrimers With Rapid Photodegradation Response. | Advanced supramolecular assemblies with predefined lifetimes and rapid responses to stimuli are in high demand for applications such as biomedical delivery systems. However, such assemblies are rarely able to respond rapidly and completely to stimuli, with predictable changes in morphology. Here, we introduce monodispe... |
41640325 | Constructing Denser Hydrogen-Bonding Networks in Polyoxometalate-Based Coordination Polymers for Enhancing Proton Conduction. | It is urgent and significant to design and fabricate long-range ordered crystalline proton-conductive materials and study their proton conduction mechanisms. Two new polyoxometalate-based coordination polymers, named CUST-963 and CUST-964, have been constructed by combining Keggin-type H<sub>4</sub>SiW<sub>12</sub>O<su... |
41640307 | Versatile Chitosan-Based Hydrogel Dressings for Multi-Scenario Wound Management. | Despite the great self-regeneration ability of skin, severe defects require the intervention of functional dressings for effective healing. Hydrogels are ideal candidates for wound administration because of their high hydration, structural porosity, and extracellular matrix mimicking properties. Chitosan (CS) is the co... |
41640298 | Monooxygenase Activity of Indoleamine 2,3-Dioxygenase. | Indoleamine 2,3-dioxygenase (IDO) is a heme-dependent enzyme that catalyzes the first, rate-limiting step of the kynurenine pathway─the oxidation of l-tryptophan to <i>N</i>-formylkynurenine (NFK). IDO-catalyzed depletion of tryptophan levels and accumulation of kynurenine pathway metabolites is an important control me... |
41639476 | Mechanistic insights into the noncovalent inhibition of SARS-CoV-2 PLpro: a multiscale computational study. | The papain-like protease of SARS-CoV-2 (PLpro2) is integral to viral polyprotein cleavage and the modulation of host immune responses, positioning it as a critical target for antiviral drug development. Here, we elucidate the molecular mechanisms governing the noncovalent inhibition of PLpro2 through a comprehensive co... |
41639425 | Mechanotransduction through T cell receptors: consensus, controversies and future outlooks. | Immune cells rely on surface immunoreceptors to sense their environment. While the downstream signaling pathways of many immunoreceptors are well characterized, the initial molecular events that trigger signaling upon ligand engagement remain incompletely understood. Here, in this Review, we outline our current underst... |
41639426 | TFEB, FOXO3 and TLR4 in resveratrol-induced autophagy in a mucopolysaccharidosis IIIB mouse model. | Mucopolysaccharidosis (MPS) type IIIB is the progressive degeneration of the central nervous system. Resveratrol is proposed as a potential therapeutic molecule as a drug reducing inflammation and for improving behavior of MPS mice. Here we investigated autophagy in correlation with immune response in an MPS IIIB mouse... |
41639062 | Oncolytic viruses: advanced strategies in cancer therapy. | Oncolytic viruses (OVs) represent a promising strategy in cancer immunotherapy, as they selectively infect and lyse tumor cells while simultaneously triggering robust antitumor immune responses. By inducing immunogenic cell death, OVs enhance tumor antigen presentation and initiate a systemic immune response, effective... |
41572849 | Machine-learning-guided design of MOF-based electrocatalysts for sustainable ammonia production. | Metal-organic frameworks (MOFs) are highly versatile materials known for their exceptional properties, including high specific surface area, tunable pore structures, and multifunctionality, making them invaluable in fields of electrochemical ammonia synthesis. Over the past decade, MOF-based systems have evolved from i... |
41543355 | Lattice-matched MOF-on-MOF heterostructure for robust photocatalytic nitrogen fixation. | Herein, a structurally matched MOF-on-MOF heterostructure (MIL-68(In)@Co-HHTP) was constructed. Benefiting from the lattice-aligned interface, the heterostructure enables efficient charge transfer, delivering a superior photocatalytic nitrogen fixation performance with the NH<sub>3</sub> yield rate of 76.10 µmol g<sup>... |
41543340 | Solvent-dependent self-assemblies with multi-inverted circularly polarized luminescence based on 9,10-distyrylanthracene. | Ordered self-assembly of the amphiphilic aggregation-induced emission molecule DSA-Chol yielded assemblies with outstanding chiral luminescent properties. Modulation of the poor solvent ratio led to significant amplification and multiple inversions of the CPL signals of the assemblies. |
41537477 | From intrinsic structures to supramolecular organization: exploring the diversity and origins of chirality in metal clusters. | Nanoscale chirality has emerged as a dynamic and expanding field of research, with particular emphasis on systems that exhibit optical activity in both the ground and excited states, enabling promising prospects in areas such as enantioselective catalysis, circularly polarized photonics, advanced bioimaging, anti-count... |
41536207 | Theoretical investigation of dioxygen activation and hydrocarbon oxidation catalysed by bioinspired metal-organic frameworks. | Dioxygen activation by a bioinspired FeZn<sub>4</sub>(prv)<sub>4</sub>(btdd)<sub>3</sub> MOF to form high-spin (<i>S</i> = 2) iron(IV)-oxo active species was revealed to proceed <i>via</i> two-state reactivity. The iron(IV)-oxo species containing the Lewis acid Zn<sup>2+</sup> cation hydroxylates cyclohexane with an en... |
41527895 | Esterification synthesis of iron oxide nanoparticle tracers for magnetic particle imaging (MPI). | The potential for producing iron oxide magnetic particle imaging (MPI) tracers using an alternative synthesis method based on esterification of iron oleate with oleyl alcohol was evaluated. The defined reaction mechanism allows monitoring of reaction progress with Fourier Transform Infrared (FTIR) spectroscopy. The inf... |
41527786 | Hydrogen bond driven supramolecular assemblies during hybrid mesoporous silica films structuration. | Understanding the molecular architecture of hybrid mesoporous materials remains a challenge due to the complexity of weak molecular interactions that govern the formation of the hybrid interface and the distribution of organic moieties. In this study, we employed infrared spectroscopy to systematically investigate the ... |
41524534 | Two-dimensional conducting polymers: synthetic strategies and emerging applications in sensor technologies. | Two-dimensional conducting polymers (2DCPs) are characterized by suppressed chain entanglement and interchain disorder, enabling continuous in-plane charge transport, enhanced specific surface area, and retained mechanical compliance. This review provides a structured overview of interfacial synthesis, space-confined g... |
41493402 | Gas transformations within metal-organic cages. | The efficient transformation of gaseous molecules into value-added products remains a central challenge in sustainable chemistry, limited by the low reactivity of some gases and the complexity of achieving product selectivity. Metal-organic cages (MOCs), with their tunable cavities and dynamic host-guest interactions, ... |
41143977 | Tuneable emission from disordered to ordered aggregates in substituted 9,10-dihydroanthracene polymers. | The fluorescence behaviour of polymers featuring 9,10-dihydroanthracene and oligothiophenyl units was explored under solvent-induced aggregation. Time-resolved spectroscopy using a streak camera and spectral deconvolution revealed multiple aggregate species with distinct characteristics accounting for the unusual emiss... |
42004267 | Chiral Au@Ag Core-Shell Nanoparticles for Enantioselective SERS Detection of Bio-Relevant Chiral Molecules. | Chiral Au@Ag core-shell nanoparticles were synthesized by asymmetric Ag deposition on premade chiral Au nanorods and employed for enantioselective surface-enhanced Raman scattering (SERS) of bio-relevant chiral molecules. Electron tomography revealed nanoscale asymmetry arising during Ag shell growth, while circular di... |
41907377 | Multimodal Imaging By Polydopamine Nanoparticles for Effective Pre- and Intra-Operative Lymph-Node Screening in Gastric Cancer Using Mice Model. | <h4>Introduction</h4>Systematic lymphadenectomy is crucial in gastric cancer surgery for improving patient prognosis. However, current clinical lymph node (LN) mapping relies on fragmentary single-modal imaging agents, which suffer from low accuracy in N-staging and lack integration between preoperative and intraoperat... |
41869441 | A Comprehensive Review of Nanotechnological Innovations in Cancer: from Molecular Pathways to Clinical Applications. | This review offers an inclusive overview of current cancer treatment options. It examines emerging trends in molecular mechanisms, therapeutic challenges, and nanotechnological innovations that may significantly improve patient outcomes. Cancer is a complex disease characterized by unregulated cellular proliferation, i... |
41831980 | Cyclodextrin-enhanced edible coatings for extending shelf life of perishable foods: A comprehensive review with emphasis on fruits and vegetables. | Global food loss-approximately one-third of all production-demands innovative preservation technologies. Cyclodextrin (CD)-enhanced edible coatings offer a promising sustainable solution combining biodegradability, food-grade safety, and multifunctional preservation capabilities. This review systematically examines CD ... |
41800257 | Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress. | Radiation-induced intestinal injury (RIII) represents a major, clinically recalcitrant complication of radiotherapy, with current protective options remaining extremely limited. In this study, we identify tyrosol, a gut-derived phenolic metabolite enriched in the feces of irradiated mice, as a potent radioprotective ag... |
41769086 | Enhanced antibacterial activity of antimicrobial peptide-antibiotic combinations against multidrug-resistant bacteria. | The rapid emergence of multidrug-resistant (MDR) bacteria has severely compromised the efficacy of conventional antibiotics and intensified the global antimicrobial resistance crisis. Antimicrobial peptides (AMPs) have attracted considerable interest as adjunctive agents due to their membrane-active mechanisms and immu... |
41743230 | Tumor radiosensitization with gold nanoparticles: evolving strategies to improve tumoral gold uptake and catalyze future clinical translation. | Radiation therapy is integral to the treatment regimens of over 50% of cancer patients. However, it is not biologically targeted to just the tumor, leading to adverse effects in peritumoral normal tissue. Selective uptake of gold nanoparticles (AuNPs) by tumors realizes tumor-specific radiosensitization via increased s... |
41745946 | Research Progress on Pathogenesis and Prevention of Avian Leukosis Virus J Subgroup (ALV-J). | As a major retrovirus threatening global poultry farming, Avian Leukosis Virus Subgroup J (ALV-J) has expanded its host range since discovery, extending from conventional broilers to layer chickens and native breeds. Its diverse oncogenic manifestations, including myeloid leukemia, hemangiomas, and tumors of immune and... |
41745660 | Molecular and Physiological Adaptations to Seasonal Training in Elite U18 Ice Hockey Players. | Monitoring adolescent team-sport athletes may benefit from combining performance and molecular markers, but empirical evidence supporting this approach in youth team sports remains limited.<h4>Objective</h4>Our study investigated molecular and physiological adaptations to seasonal training in elite U18 ice hockey playe... |
41744720 | Electrochemical/Colorimetric Dual-Mode Aptasensor Based on CuZr-MOF and Fe<sub>3</sub>O<sub>4</sub>@ZIF-8 for Detection of Malathion in Vegetables. | In on-site rapid detection, the electrochemical method boasts high sensitivity and rapid response capabilities, while the colorimetric method can provide intuitive visual readings suitable for on-site screening. Therefore, this study developed an innovative dual-mode electrochemical/colorimetric aptasensor for the accu... |
41744717 | Highly Sensitive Electrochemiluminescence Analysis of miRNA-107 Using AIE-Active Polymer Dots as Emitters. | The ultrasensitive detection of microRNA-17 (miRNA-107) is required for clinical diagnosis. In this work, an aggregation-induced electrochemiluminescence (AIECL) sensor was developed for the quantification of miRNA-107, in which AIECL-active polymer dots (Pdots) were characterized by transmission electron microscopy, u... |
41728087 | Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction. | Biomolecular condensates have emerged as fundamental organizers of cellular biochemistry. Increasing evidence indicates that cellular condensates exhibit a broad spectrum of material properties-including viscoelastic, soft glass-like, gel-like, and quasi-solid regimes-that are intimately coupled to indicated diverse de... |
41727270 | Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis. | Correcting the disordered metabolism and achieving dynamic, comprehensive management of chronic diabetic wounds remains a significant challenge. This study presents a double-network dynamic hydrogel exhibiting long-term anti-inflammatory, antioxidant properties, and tunable mechanical strength. The hydrogel is primaril... |
41726729 | Physicochemical Characterization and <i>In Vitro</i> Anti-Inflammatory Assessment of Novel Sodium Alginate Sponges Loading <i>Andiroba</i> Oil (<i>Carapa guianensis</i> Aubl.) for Skin Dressings. | This study describes the structural characterization of a novel formulation based on sodium alginate sponges loading the Amazonian <i>andiroba</i> oil (<i>Carapa guianensis</i> Aubl.) as a strategy for developing topical anti-inflammatory dressings. The characterization by X-ray diffraction revealed the amorphous profi... |
41726711 | Synthesis and Fabrication of MXene/MWCNT Nanocomposites for Electronic Detection of Sulfamethoxazole. | The significant demand for accurate and accessible sensors has led to significant advances in nanotechnology. This is especially relevant to the use of advanced nanomaterials; in this study, a hybrid composite of MWCNTs and MXene was produced. The MXene/MWCNT composite was made by sonication procedures and subsequently... |
41726665 | Photophysical and Photochemical Properties of a Curcumins Family: A Combined Computational and Experimental Investigation. | In the present study, photophysical and photochemical properties of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its seven derivatives, encompassing esterified curcumins and their bisdemethoxy conjugates have been studied computationally and experimentally to explore their suitability as ... |
41716383 | Aryl hydrocarbon receptor: a potential target for natural products in the treatment of inflammatory bowel disease. | Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease driven by genetic, immune, and environmental factors, and its incidence continues to increase worldwide. The existing therapies often face the limitations of insufficient response, obvious side effects, and high medical burden, so it is urgen... |
41716344 | 3D coaxial bioprinting of RADA16-I self-assembling peptide hydrogel. | Peptides that self-assemble into hydrogels provide a dynamic microenvironment for various cell types. Combining top-down extrusion 3D bioprinting with bottom-up self-assembly of peptide hydrogels offers an innovative approach to biofabrication. However, modest mechanical properties of peptide hydrogels pose challenges ... |
41716342 | Biomaterial-assisted gene therapy for bone repair. | Bone defects are a prevalent and serious condition that can give rise to pain, deformity, infection, and even serious consequences. However, conventional treatment modalities, whether conservative or surgical, are often limited by suboptimal outcomes, insufficient resources, or potential risks. Biomaterial-assisted gen... |
41716313 | PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition. | <h4>Introduction</h4>Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, characterized by dense desmoplastic stroma, metabolic reprogramming, and poor therapeutic response. Stromal desmoplasia limits drug penetration, while glycolytic adaptation supports tumor progression. Effective strategi... |
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