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41716278 | Molecular mechanisms involved in <i>Plasmodium</i> gametocytogenesis. | Malaria, a disease caused by protozoa of the genus <i>Plasmodium</i>, remains a major challenge for global public health. The persistence of disease transmission to the mosquito vector depends on the differentiation of asexual blood-stage parasites into gametocytes, a process known as gametocytogenesis. Interrupting th... |
41716273 | Interactions of bile acids and gut microbiota modulate neurological health: a comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals. | Bile acids (BAs), classically regarded as detergents for dietary lipid absorption, have emerged as pivotal signaling molecules with systemic endocrine functions. The discovery of the Farnesoid X Receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) as BAs-activated receptors unveiled their profound influences o... |
41710329 | Highly Ordered T6 Organic Semiconductor Networks on MoS<sub>2</sub> Nanosheets for Optoelectronic Applications. | Van der Waals 2D crystals, with their dangling bond-free surfaces and extremely low roughness levels, are highly appealing substrates for the epitaxial growth of organic semiconductors. The growth has important consequences in the fabrication of organic electronic components such as organic light diodes. Here, using a ... |
41708237 | Understanding sub-cellular mechanochemical correlations of the neonatal extrahepatic bile duct extracellular matrix by atomic force microscope-Infrared spectroscopy. | <h4>Background</h4>The neonatal extrahepatic bile duct (EHBD) is highly susceptible to injury and fibrotic remodeling, yet the sub-cellular mechanochemical basis of this vulnerability remains poorly understood. Atomic force microscopy coupled with infrared spectroscopy (AFM-IR) enables simultaneous mapping of stiffness... |
41704878 | Intelligent packaging films based on anthocyanins: A review of structural properties, biodegradable polymers, application and prospects in food freshness monitoring. | In response to global food safety concerns, this review presents a systematic evaluation of anthocyanin-based packaging films, emphasizing the innovative integration of diverse biopolymer matrices and targeted stabilization strategies. The research gap addressed herein lies in the synergistic mechanisms between anthocy... |
41696153 | Targeting multidrug-resistant <i>Candida</i>: Cu<sub>x</sub>Te nanoflowers synergistically facilitate fungal clearance via cuproptosis death and host immune activation. | <i>Candida</i> species are common infectious pathogens that can cause invasive infections with potentially life-threatening consequences. Current treatments for invasive <i>Candida</i> infections are primarily azoles and echinocandins. However, emerging antifungal drug resistance compromises therapeutic efficacy. Herei... |
41683966 | Metal-Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review. | Cancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. The unique properties of metal-organic frameworks (MOFs), which offer high surface areas, tunable structures, and biodegradable properties, make them promising candidates fo... |
41683957 | SMURF2 in Anticancer Therapy: Dual Role in Carcinogenesis and Theranostics. | Cancer is a heterogeneous disease at the cellular level and analyzing the genetic and molecular profile is essential for targeted therapy. Cancer cells continue to mutate, often resulting in drug resistance. In addition, cancers such as triple-negative breast cancer (TNBC) lack the target proteins used in some of the m... |
41683524 | Genome-Driven Discovery of Anti-MDR Bacterial Heptapeptides from a Cold-Seep-Derived <i>Bacillus</i> Strain. | With the increasing emergence of multidrug-resistant (MDR) bacteria, there is an urgent need to discover new antibiotics. In this study, genome mining coupled with anti-bacterial assay guided the targeted isolation of two new heptapeptides nobilamide Q3 (<b>1</b>) and R3 (<b>2</b>). These compounds were identified as n... |
41683520 | Bacterial Cyclodipeptides Inhibit Invasiveness and Metastasis Progression in the Triple-Negative Breast Cancer MDA-MB-231 Mouse Model. | Triple-negative breast cancer (TNBC) is a highly aggressive subtype linked to a high rate of metastasis and low survival rates worldwide. Bacterial cyclodipeptides (CDPs) demonstrate anticancer properties by targeting multiple signaling pathways. The impact of CDPs on TNBC metastasis was evaluated both in vitro and in ... |
41683523 | Imine-Thiocarbamate Hybrid Pincer Systems: From Mechanochemical Activation to Cytotoxicity Evaluation of the Cyclopalladated Derivatives. | Organometallic and metal-organic compounds are widely used in different fields of chemistry and allied disciplines, including bioinorganic and medicinal chemistry. Of particular interest is the development of novel potential anticancer agents based on palladium(II) complexes of the so-called pincer-type ligands, featur... |
41683521 | Metal-Organic Frameworks for Precision Phototherapy of Breast Cancer. | Breast cancer remains the most common and leading cause of cancer deaths among women worldwide. The efficacy of conventional therapies is often hampered by off-target effects and multidrug resistance. Phototherapy, encompassing photodynamic therapy (PDT) and photothermal therapy (PTT), has gained significant attention ... |
41683141 | Antidepressant Mechanisms of L-Theanine in Tea Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations. | L-theanine is a bioactive non-protein amino acid predominantly derived from tea plants (<i>Camellia sinensis</i>), widely recognized for its potential benefits in mood regulation and psychological health. Despite its promising neuropsychological profile, the specific molecular targets and mechanisms underlying its anti... |
41683132 | Marine Bioactive Substances in Precision Nutrient Delivery to the Gut and Advances in Microbiome Regulation: A Narrative Review. | Marine bioactive substances exhibit structural diversity and function-specific properties, attracting considerable interest in their potential applications in targeted nutritional delivery to the gut and microbiota regulation. These bioactive components, sourced from seaweed, marine crustaceans, and microorganisms, inc... |
41683131 | Rational Design and Virtual Screening of Antimicrobial Terpene-Based Leads from <i>Marrubium vulgare</i> Essential Oil: Structure-Based Optimization for Food Preservation and Safety Applications. | <i>Pseudomonas aeruginosa</i> elastase LasB accelerates refrigerated food spoilage through proteolytic degradation of muscle and milk proteins. While <i>Marrubium vulgare</i> essential oil terpenes exhibit antimicrobial activity, their weak potency and nonspecificity limit direct food preservation applications. This co... |
41682527 | Paper-Based Analytical Devices Coupled with Fluorescence Detection and Smartphone Imaging: Advances and Applications. | Paper-based analytical devices have emerged as a versatile and cost-effective platform for on-site chemical and biological analysis. The integration of fluorescence detection with smartphone imaging has significantly enhanced the analytical performance and portability of these systems, enabling sensitive, rapid, and us... |
41682115 | Contrasting Catalytic Pathways in Lignin Pyrolysis: Deoxygenative Cracking over HZSM-5 Versus Repolymerization-Coking over Activated Carbon. | Catalytic pyrolysis is a crucial technology for lignin valorization, where the catalyst support itself can play a pivotal role in influencing the catalytic process. This study systematically investigates and compares the distinct catalytic effects of two commonly used catalyst supports, HZSM-5 zeolite and activated car... |
41681646 | Exogenous Gibberellic Acid (GA<sub>3</sub>) Enhances Mango Fruit Quality by Regulating Resource-Related Metabolic Pathways. | Efficient resource allocation during fruit expansion and ripening is critical for enhancing mango (<i>Mangifera indica</i> L.) productivity and fruit quality. A study was conducted to quantify the effects of foliar-applied GA<sub>3</sub> at concentrations of 0 (control), 50 (GA50), 100 (GA100) and 200 (GA200) mg L<sup>... |
41681473 | Identification and Functional Analysis of miRNAs in the Cauda Epididymis of Yak and Cattle. | The yak represents a distinct domestic animal species that predominantly inhabits the Qinghai-Tibet Plateau and adjacent areas, possessing considerable value in both scientific and economic contexts. Compared to animals that mainly dwell on plains, such as cattle, the sperm maturation process in yak exhibits a certain ... |
41681298 | High-Pressure High-Temperature Nanodiamond-Modified ZnO Nanocomposites as Promising Photocatalysts: Synthesis and Characterization. | Zinc oxide (ZnO) nanostructures suffer from fast electron-hole recombination, limiting their applicability in photocatalytic environmental remediation, and carbon additives such as detonation nanodiamonds (DNDs) are constrained by their high defect density. To address this, ZnO nanocomposites modified with high-pressur... |
41681291 | Hybrid Interfaces of 2D Materials with Polymers for Emerging Electronics and Energy Devices. | Two-dimensional (2D) materials offer exceptional electrical, optical, and mechanical properties but face challenges in terms of scalability, stability, and integration. Hybridizing 2D materials with polymers provides an effective route to overcome these limitations by enabling tunable interfaces, mechanical compliance,... |
41681287 | MOF Derivatives Confined Within Self-Supporting Bamboo Substrates with Hierarchical Porous Architectures for Long-Term Cycling Stability in Zinc-Air Batteries. | The relatively poor cycle stability of zinc-air batteries (ZABs) hinders their widespread application, while self-supporting electrode materials have shown great potential in enhancing the cycling stability of ZABs. To construct a self-supporting electrode, bamboo was employed as a sustainable precursor, and a two-step... |
41679216 | EuFe-MOF exhibiting excellent peroxidase-like activity and red fluorescence for colorimetric/fluorescence dual-modal sensor to detect xanthine in aquatic products. | Aquatic products are a vital nutrient source in human diet. Xanthine (XA), a key product of purine nucleotide metabolism, is closely linked to the freshness of aquatic products. Herein, we report a bimetallic metal-organic framework (MOF), EuFe-MOF, that exhibits excellent peroxidase (POD)-like activity and red fluores... |
41677657 | Targeting Amyloid Beta Aggregation and Neuroinflammation in Alzheimer's Disease: Advances and Future Directions. | Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly. Among the diverse pathological features of AD, amyloid beta (Aβ) aggregation and neuroinflammation are recognized as central and interlinked mechanisms driving disease progression. This review focu... |
41675421 | The hidden language of gut-derived lipopolysaccharides: fine chemistry, huge immunological consequences. | Lipopolysaccharides (LPSs) from Gram-negative bacteria are traditionally viewed as potent "endotoxins" recognized by the immune system and capable of triggering robust inflammation. However, increasing evidence from gut commensals is dismantling this one-dimensional view. The gastrointestinal tract is indeed the major ... |
41671821 | Drug-reinforced metal-organic framework nanozyme for combined treatment of ischemia/reperfusion acute kidney injury. | It is well established that 7,8-dihydroxyflavone (DHF) exerts protective effects against ischemia-reperfusion injury (IRI)-induced acute kidney injury (AKI). However, its clinical translation has been largely restricted due to rapid metabolism and insufficient bioavailability. To address this challenge, we designed a m... |
41671803 | The adsorption and enantioselective properties of threonine-based Zn-MOF composite supported on agar biomass aerogel. | The adsorption activity and enantioselectivity of a novel chiral metal-organic framework based on zinc and a ligand obtained by condensation of threonine and 4-pyridine carbaldehyde (Zn-MOF), as well as its composite with agar (AG/Zn-MOF-0.4), were estimated by inverse gas chromatography. Specific retention volumes (V<... |
41660152 | Formulation and Delivery Systems of Cocaine and Methamphetamine Scent Mimics. | Narcotic scent mimics, which are chemicals that emit a perceivable scent similar to that of the illicit drug but do not possess the health and addiction risks of the drug, have applications ranging from canine training in law enforcement agencies to antinarcotic public education. However, low-cost and easily accessible... |
41657397 | Discovery of bioactive compounds from medicinal plants: insights into <i>Wrightia tinctoria</i> as a potential antistaphylococcal agent targeting clumping factor A. | <i>Staphylococcus aureus</i>, a major human pathogen, exhibits strong survival abilities both inside and outside host cells. The increasing prevalence of antibiotic-resistant strains presents a major challenge to modern medicine. Bioactive compounds from medicinal plants represent a potential alternative, owing to thei... |
41651417 | Structural basis of DNA aptamer A58 targeting the N-terminal domain of sarbecoviruses nucleocapsid protein. | In the post-pandemic era, the persistent threat of coronaviruses demands broad-spectrum antiviral therapeutic strategies. The SARS-CoV-2 nucleocapsid protein (N protein), an essential factor for genome packaging and immune modulation, poses a promising antiviral target. Here, we determined the crystal structure of the ... |
41651322 | Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo. | The development of biomaterials that mimic native bone remains a major challenge in regenerative medicine. Here, we present a bioinspired platform using high-density collagen hydrogels with tunable mineral content. These engineered microenvironments promote rapid osteogenesis in vitro without osteogenic supplements and... |
41647443 | Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti-<i>Mycobacterium tuberculosis</i> agents. | The updated guidelines from the World Health Organization highlight that treatment options for multidrug-resistant tuberculosis (MDR-TB) remain limited due to the scarcity of effective drugs. As a result, there is an urgent necessity to develop novel or repurposed drugs that demonstrate efficacy against multidrug-resis... |
41647426 | Recent progress in the preparation and environmental applications of functionalized adsorbent hydrogel: a review. | This review highlights recent advancements in the preparation and environmental applications of functionalized adsorbent hydrogels, with a focus on their role in addressing global water pollution and scarcity. Hydrogels, with their unique three-dimensional crosslinked structures and exceptional water retention capabili... |
41647425 | Chemical tailoring of heteroatom (P, S, Si) doping of COF-PEDOT for adsorption of paracetamol: perspective from DFT studies. | The growing occurrence of pharmaceutical contaminants in aquatic systems has intensified the demand for advanced nanostructured materials capable of selective adsorption and removal of such pollutants. Paracetamol, a commonly used analgesic and antipyretic drug, is frequently detected in wastewater and poses severe eco... |
41647417 | Silver citrate engineered NiCo<sub>2</sub>S<sub>4</sub>/MOF-derived oxide@carbon frameworks for high-energy hybrid supercapacitors. | Metal-organic frameworks (MOFs) offer a versatile platform for designing high-performance supercapacitor electrodes, but their poor intrinsic conductivity and structural instability limit practical application. Here, we report an silver-citrate-modified NiCo<sub>2</sub>S<sub>4</sub>@calcined-MOF composite derived from ... |
41647423 | The application of ICG-based photodynamic therapy combined with nanotechnology in tumor treatment. | Despite remarkable progress in tumor therapy, key challenges-including the immunosuppressive "cold" tumor microenvironment and treatment resistance-remain unresolved and severely impede clinical outcomes. Indocyanine Green (ICG)-based Photodynamic Therapy (PDT), a modality that activates the photosensitizer ICG to gene... |
41647416 | Exploring natural colorants from plants to insects: chemistry, functions, and modern uses. | Natural pigments and dyes provide a rich interface between biodiversity and chemistry, offering structurally diverse molecules with distinctive reactivity and bioorganic relevance. These compounds occur in plants, marine organisms, fungi, bacteria, insects, birds, animals, and mineral sources. They encompass major chem... |
41647419 | Novel pyridine-heterocycle hybrids: synthesis <i>via</i> Hantzsch and Biginelli reactions, docking simulations, and anticancer activity. | Cancer is a serious global health issue and remains one of the top causes of death worldwide. To overcome the problems of the existing anticancer drugs in terms of specificity and resistance, a new class of hybrid bis-heterocyclic compounds with a pyridine bridge has been designed and synthesized <i>via</i> the Hantzsc... |
41647405 | Electrospun PAN + CALF-20 fibers: characterization and removal of Pb(ii) and Cu(ii) ions from aqueous solution. | This work presents the first report of integrating the Zn-based metal-organic framework (MOF), CALF-20, into electrospun polyacrylonitrile (PAN) nanofibers for wastewater treatment. CALF-20, previously explored for CO<sub>2</sub> capture, is applied here for the first time in fiber-based composite form manufactured <i>... |
41647407 | Acid-responsive metal organic frameworks with photothermal effects for osteoarthritis multiple therapy. | Early osteoarthritis (OA) with reversible ability appears to lack features other than intense acute inflammation. Herein, we developed a pH-responsive metal organic framework (MOF) system based on phenylboronic acid (PBA) and O-hydroxyl pH-dependent reversible switches. Click chemistry enables a simple and environmenta... |
41647404 | Progress in mechanochemical synthesis of catalysts for the CO<sub>2</sub> processes: a step towards carbon neutrality. | This review examines mechanochemical synthesis as a solvent-free and scalable approach for high-performance CO<sub>2</sub> reduction catalysts. Mechanical energy-driven methods, particularly high-energy ball milling, enable controlled defect formation, enhanced metal-support interactions, and atomic dispersion, thereby... |
41647399 | Structure prediction of porous organic crystals. | In this work, we explore the possibility of applying automated crystal structure prediction to reproduce the experimentally identified metastable porous polymorphs. Using our recently developed High-Throughput Organic Crystal Structure Prediction () framework, we conducted a systematic study on five representative orga... |
41647035 | Post-synthetic gridization enhances spin-flip dynamics, horizontal alignment, and ozone resistance in solution-processable TADF macrocycles. | Nanoemitters play a pivotal role in advancing OLED technologies toward flexible, efficient, and sustainable display platforms. However, current quantum dots and perovskite LEDs suffer from structural instability and environmental sensitivity, limiting their scalability. Here, we introduce a post-synthetic gridization s... |
41647042 | Virus-like particles based on plant viruses and bacteriophages: emerging strategies for the delivery of nucleic acid therapeutics. | Nucleic acids have emerged as a robust modality for the treatment of various diseases that are considered undruggable in the context of small-molecule therapeutics. However, their clinical translation is hindered by the lack of safe and effective delivery across extracellular and intracellular barriers. Mammalian viral... |
41645508 | Integrated multi-omics analyses reveal that p-coumaroyl-CoA 2'-hydroxylases act upstream of stilbene synthases to mediate oxyresveratrol biosynthesis in mulberry (Morus alba L.). | Oxyresveratrol is a bioactive stilbenoid with strong antioxidant, anti-inflammatory, and tyrosinase-inhibitory activities that accumulates in mulberry (Morus alba L.) tissues. Despite its relevance, the biosynthetic origin of oxyresveratrol has remained unclear, with competing hypotheses proposing either hydroxylation ... |
41643443 | Fowl adenovirus infections: A comprehensive review of prevalence, pathogenesis, diagnosis, control, and economic impact. | Fowl adenoviruses (FAdVs), used to be recognized as non-malignant pathogens, have now evolved into notable pathogens threatening global poultry productions. This review synthesizes current knowledge on the escalating challenges posed by FAdVs. There is already a wide variety of genetic types or strains within the virus... |
41643349 | MXene-molecularly imprinted polymer composite for enhanced adsorption and enrichment of puerarin and its metabolites. | A MXene-based molecularly imprinted polymer (MXMIP) composite was developed for the enrichment and detection of puerarin and its metabolites in complex biological samples. As an ideal substrate material, MXene can make the recognition sites within the MIP matrix more easily exposed compared to conventional MIP. Through... |
41643292 | Biomimetic MOF/MIPs carbohydrate microfluidic paper chip: A versatile sialic acid detection platform from point-of-care screening to food rapid analysis. | The development of new technologies for at-home self-testing holds promising potential for chronic disease management and monitoring. Recently, microfluidic paper-based analytical devices (μPADs) have demonstrated versatile capabilities for point-of-care testing (POCT). Sialic acid (SA), closely linked to the modificat... |
41643293 | Identification of molecularly targeted therapy-induced immunopeptidome in diffuse midline glioma (DMG). | <h4>Introduction</h4>Diffuse midline glioma (DMG) with the H3K27M mutation remains one of the most treatment-resistant pediatric brain tumors, in part due to limited antigen presentation and immune visibility. Exploring how glioma biology and therapeutic interventions influence immune recognition offers new opportuniti... |
41640248 | Ascorbic Acid-Assisted Self-Assembly of 4-Aminothiophenol to Enhance Interfacial Adhesion between Copper and Ajinomoto Build-up Film. | High-speed data transmission requires the formation of fine and smooth Cu wiring, which inevitably causes a decline of interfacial bonding strength between Cu and the insulating dielectric layer. In this work, 4-aminothiophenol (4-ATP) is used as a bifunctional promoter for the interfacial adhesion between a Cu foil an... |
41640216 | Supramolecular-Based Ion Separation Membranes for Direct Separation of Concentrated Mixed-Salt Solutions. | Efficient ion separation from concentrated brines is critical for sustainable water resource utilization, zero-liquid discharge, and strategic ion recovery, yet it remains a formidable challenge for conventional ion-selective membranes (ISMs). Existing ISMs rely on weak ion-pore interactions, limiting their applicabili... |
41640133 | Poly(<i>o</i>-phenylenediamine) as an Organic Filler for Enhancing the Mechanical and Antibacterial Performance of Chitosan Films. | Understanding structure-property relationships is essential for designing multifunctional biopolymer composites that integrate mechanical robustness, barrier performance, and antimicrobial activity in sustainable materials. Chitosan (CS) exhibits excessive hydrophilicity, limited mechanical strength, and poor moisture ... |
41640111 | Dual agonism and selective T-cell depletion activity of a PD-1-directed antibody for treating autoimmune diseases. | Precise inhibition of autoreactivity without concomitant induction of general immunosuppression is an overarching goal that remains elusive for the treatment of autoimmune diseases. PD-1 is preferentially expressed on activated T cells that drive autoimmunity. These PD-1<sup>+</sup> T cells could serve as a target for ... |
41640022 | Ultrathin Metal-Organic Framework as an Allosteric Regulator for Albumin-Responsive Therapy of Diabetic Infections. | Customizing sense-and-respond programs that link natural actuations with user-defined cues has emerged as a promising strategy for modulating life processes. Herein, a metal-organic framework (MOF)-based synthetic receptor system is presented for realizing customized biological functions using write-in signaling gates.... |
41639996 | Electrocatalytic Nitrate Reduction to Hydroxylamine: Breaking the Activity-Selectivity Trade-Off by Designer Bifunctional Metal-Organic Frameworks. | Electrocatalytic nitrate reduction reaction (NitRR) offers a promising route for hydroxylamine (NH<sub>2</sub>OH) synthesis under ambient conditions. However, the inherent activity-selectivity trade-off limits the overall performance. To overcome this challenge, a bimetallic NiMg-MOF-74 electrocatalyst is designed for ... |
41639938 | Bimetallic MOFs With Enzyme-Mimetic Active Sites for Nerve Agent Detoxification: Synergistic Insights Into Impeccable Performance From Experiment and Theory. | Nerve agents pose severe risks to human health, underscoring the need for efficient decontamination strategies. This study explores metal-organic frameworks (MOFs) as catalytic platforms owing to their structural tunability, redox-active metal centers, and abundance of Lewis acidic sites. Single- and bimetallic UiO-ser... |
41639736 | Isolation, identification, and whole genome sequencing analysis of influenza A virus clinical isolates from Shanghai, China, during 2022-2023. | Influenza A virus remains a persistent threat, continuously evolving and contributing to seasonal epidemics and potential pandemics. In this study, we analyzed clinical samples collected from pediatric patients in Shanghai between 2022 and 2023, following the SARS-CoV-2 pandemic, to assess the genetic diversity of circ... |
41639692 | De novo protein design: a transformative frontier in clinical protein applications. | <h4>Background</h4>Protein biologics are indispensable in disease prevention, diagnosis, and therapy, yet their development remains largely constrained by reliance on native protein scaffolds, resulting in long development timelines, limited structural and functional tunability, challenges in manufacturing consistency,... |
41639585 | Template-in-template assembly nanostructured microspheres for high performance chromatography. | Concurrent precision architecture of morphology and nanostructure in mesoporous microspheres is pivotal for high performance separations. Herein, we develop a template-in-template assembly nanostructuring (TiTAN) strategy to precisely synthesize monodisperse microspheres with ordered mesoporous nanostructure. Microflui... |
41639457 | Single-molecule dynamics of the TRiC chaperonin system in vivo. | The essential chaperonin T-complex protein ring complex (TRiC) (also known as chaperonin containing TCP-1 (CCT)) mediates protein folding in cooperation with the co-chaperone prefoldin (PFD)<sup>1-5</sup>. In vitro experiments have shown that the cylindrical TRiC complex facilitates folding through ATP-regulated client... |
41639456 | Bacterial immune activation via supramolecular assembly with phage triggers. | Bacteria use diverse mechanisms to protect themselves against phages<sup>1-6</sup>. Many antiphage systems form large oligomeric complexes, but how oligomerization is regulated during phage infection remains mostly unknown<sup>7-12</sup>. Here we demonstrate that the bacterial immunity protein ring-activated zinc-finge... |
41639161 | Zn-based metal organic frameworks encapsuated cauliflower leaves-derived biochar composite for photocatalytic removal of victoria blue and crystal violet. | The rising concerns regarding the discharge of waste effluents and their side effects in our environment has ignited the minds of different researchers for finding feasible, economic and practical ways to mitigate the ongoing alarming issue. Several harmful organic dyes, pharmaceuticals and nitro-aromatic compounds etc... |
41639119 | Polygonatum cyrtonema Hua fructan ameliorates ulcerative colitis via gut microbiota modulation and follistatin targeting. | Ulcerative colitis (UC) is a chronic inflammatory bowel disease with persistent colonic inflammation and inadequate therapeutic options. The medicinal and edible plant Polygonatum cyrtonema Hua from Jiuhua Mountain contains polysaccharides with potent anti-inflammatory activities. In this study, a low-molecular-weight ... |
41639093 | Deep learning drives autonomous molecular reactions with single-bond selectivity in tetra-brominated porphyrins on Au(111). | The pursuit of autonomous chemical transformations with single-bond precision represents a central challenge in molecular nanoscience. While scanning tunneling microscopy (STM) enables site-specific reactions by directly engaging individual atoms and bonds, conventional approaches rely on expert intervention and lack r... |
41639084 | Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota. | Major Depressive Disorder (MDD) affects around 20% of people globally and is often comorbid with anxiety. This study investigates prucalopride, a serotonin type 4 receptor (5-HT<sub>4</sub>R) agonist approved for constipation, as a fast-acting anxiolytic/antidepressant using a mouse model of stress, based on corticoste... |
41639067 | Electricity-free hydrogen production from the air. | The ever-growing demand for electricity and clean water restricts widespread application of hydrogen production via water electrolysis or photocatalytic water splitting. Here, we present a self-sufficient electricity-free air-to-hydrogen system that integrates radiative cooling-enhanced water adsorption with synergisti... |
41639048 | Advances and challenges in non-canonical nucleic acids data storage. | Canonical nucleic acids (DNA and RNA) naturally store genetic information with high density and programmability, making them promising candidates for molecular data storage. However, their susceptibility to degradation under harsh conditions, such as extreme pH, nuclease activity, and chemical attack, limits practical ... |
41638995 | Synergistic Multiscale Design of Metal-Organic Framework Membrane via Biomineralization-Inspired Templating for High-Efficiency Azeotrope Separation. | Membrane-based pervaporation offers an energy-efficient route for azeotrope separation, yet fabricating membranes that combine structural integrity with precise molecular sieving remains challenging. This work introduces a biomineralization-inspired strategy to synergistically engineer metal-organic framework MIL-100 m... |
41638915 | Transition State Theory for Dissociation of Dynamic Bonding Networks. | Cell adhesion, molecular recognition, biomolecular folding and unfolding, dynamic cross-linking in soft materials, and many other phenomena involve formation or dissociation of multiple chemical bonds. Here, we study the overall time scale required to break or form <i>N</i> bonds. Strictly speaking, this time scale dep... |
41638892 | Advances in Organic Semiconductors for Solar-Driven Hydrogen Generation from Water. | Organic semiconductors offer a uniquely versatile and cost-effective platform for solar-driven hydrogen generation from water by leveraging scalable and earth-abundant material design. Their high degree of tunability in molecular, optical, and electronic structures has enabled drastic improvements in solar absorptivity... |
41638638 | Biogenesis of Au Nanoparticles from Plant-Derived Metabolites - <i>In Vitro</i> and <i>In Vivo</i> Studies. | Biomimetic gold nanoparticles (Au NPs) were synthesized via a sustainable approach without any additional toxic chemical reagents and fully characterized. It was proven that only whole aqueous extracts of <i>Rosa damascene</i> (RD) and <i>Rosa rugosa</i> (RR) are powerful enough to reduce, graft, and stabilize metallic... |
41637728 | Protein Electrostatics Tune the Singlet-Triplet Energy Gap in Natural and Engineered Phototropin Light-Oxygen-Voltage (LOV) Domains. | Photoactive flavoproteins such as Light-Oxygen-Voltage (LOV) domains serve as scaffolds for tuning the photophysics of their bound flavin cofactor through sequence mutations. This variable tuning effect has led to the development of a series of engineered LOV-based proteins that optimize fluorescence, intersystem cross... |
41637558 | Tri-Layer Solid-State Nanopore Arrays with Crosstalk Suppression for High-Throughput, Femtomolar-Level Biosensing. | Solid-state nanopore arrays are emerging as powerful tools for label-free, ultrasensitive biosensing, yet their implementation has been constrained by inter-pore crosstalk and limited fabrication uniformity. A multilayer Al<sub>2</sub>O<sub>3</sub>/Au/Si<sub>3</sub>N<sub>4</sub> nanopore architecture, produced via heli... |
41637532 | Transient Salt-Bridge-Based Supramolecular Polymers: Experiments and Theory. | The smooth decarboxylation under basic conditions of activated carboxylic acids (ACAs) is exploited to achieve a transient supramolecular polymer based on hydrogen bonds reinforced by electrostatic interactions. In particular, it is proved that when the aliphatic α,ω-diamine <b>3</b>, namely, 1,8-diamino-3,6-dioxaoctan... |
41637533 | Fe/N-Doped Carbon with Nearly Ordered Mesopores and Tunable Particle Sizes as Model Catalysts for Quantitative Evaluation of Electrocatalytic Active Sites. | Synthesizing MOF-derived carbons with not only tunable and uniform particle sizes but also ordered tubular mesoporous structures remains challenging. Moreover, the lack of precise morphological control makes it hard to clarify the relationships between structure and catalytic activity, limiting the rational design of M... |
41637521 | Nanocollision promotes locomotion of dendritic cells for tumor therapy. | Mechanical stimuli originating from extracellular matrix have been proved to affect antitumor immunity by regulating dendritic cell (DC) locomotion. However, the immunological consequences of ultrasmall bioparticle-induced nanocollision remain largely an unexplored realm despite its ubiquitous and incessant occurrence ... |
41637513 | OsRNS4-mediated cross-kingdom RNA interference is inhibited by <i>Ustilaginoidea virens</i> effector SCRE2 to promote infection in rice. | The <i>Ustilaginoidea virens</i> effector SCRE2 has been previously identified to be an essential virulence factor. To elucidate molecular mechanisms underlying SCRE2 virulence function, we identify that SCRE2 interacts with <i>Oryza sativa</i> S-like ribonuclease family member OsRNS4. As a catalytically inactive RNase... |
41637511 | Discovery and preclinical evaluation of monoclonal antibodies and bispecific engagers targeting the NKG2A inhibitory receptor. | NK and T cells are key effectors that eliminate cancer cells, but upregulation of the inhibitory receptor NKG2A on these cells attenuates antitumor immune responses. To counteract NKG2A inhibitory signaling, we identified two specific fully human monoclonal anti-NKG2A antibodies that block HLA-E ligand binding. These a... |
41637502 | Interface-engineered plasmonic covalent organic framework nanofilms on TiO<sub>2</sub> nanotubes for universal mass spectrometry imaging. | Covalent organic frameworks (COFs) hold promise for surface-assisted laser desorption/ionization mass spectrometry imaging (MSI), yet their integration with plasmonic nanostructured platforms remains unexplored. Here, we report a liquid-liquid interfacial self-assembly strategy to construct plasmonic gold nanoparticle-... |
41637450 | A nuclear CobW/WW-domain factor represses the CO<sub>2</sub>-concentrating mechanism in the green alga <i>Chlamydomonas reinhardtii</i>. | Microalgae induce a CO<sub>2</sub>-concentrating mechanism (CCM) to maintain photosynthesis when CO<sub>2</sub> is limited. Because this system consumes a substantial portion of photosynthetically generated ATP, its suppression when CO<sub>2</sub> levels rise is critical for energy balance, yet the underlying mechanism... |
41637404 | Transcriptomic analysis reveals the impact of concurrent, resistance, and endurance training on skeletal muscle. | The shared and divergent molecular mechanisms underlying skeletal muscle adaptation to different exercise modalities are not fully understood. This study aimed to compare the physiological and transcriptomic responses to 12 weeks of concurrent (CET), resistance (RES), or endurance (END) training in healthy males. While... |
41637230 | A Paddle-Wheel Binuclear Copper(II)-Based MOF for Cyclization of Propargylic Amines with Flue Gas CO<sub>2</sub> at Ambient Conditions. | Metal-organic frameworks (MOFs) exhibit attractive catalytic performance, particularly for carbon dioxide (CO<sub>2</sub>) fixation. We here developed a new MOF {Cu<sub>2</sub>(Bibt)(Apta)<sub>2</sub>}<sub>n</sub>, namely CuBA, under the solvothermal process {Bibt = (4,7-bis(1<i>H</i>-imidazol-1-yl)benzo-[2,1,3]thiadia... |
41637227 | More is Different: Theoretical Investigation on the Origin of Ligand Loading-Dependent Switching Regioselectivity in Ir-Catalyzed C-H Borylation. | The ligand loading-dependent <i>ortho</i>/<i>meta</i> switching regioselectivity in an Ir-catalyzed C-H borylation of an aromatic ester has been experimentally achieved recently, while the origin of switching regioselectivity still remains unclear. In this work, we performed density functional theory (DFT) calculations... |
41637182 | Ultrafast and Selective Adsorption of <sup>99</sup>TcO<sub>4</sub><sup>-</sup>/ReO<sub>4</sub><sup>-</sup> from Water by Nonporous Cationic Metal-Organic Framework. | Rationally designing adsorbents for the effective and selective removal of <sup>99</sup>TcO<sub>4</sub><sup>-</sup> from a water environment is extremely desired but remains a challenge. In this study, we successfully constructed a nonporous cationic metal-organic framework (MOF-1) with a three-dimensional architecture... |
41637138 | Hopfield Networks as Models of Emergent Function in Biology. | Hopfield models, originally developed to study memory retrieval in neural networks, have become versatile tools for modeling diverse biological systems in which function emerges from collective dynamics. In this review, we provide a pedagogical introduction to both classic and modern Hopfield networks from a biophysica... |
41637126 | Tuning Photocatalytic Activity in Porphyrin-Based Metal-Organic Frameworks by Controlling Charge Recombination Pathways. | Porphyrin-based metal-organic frameworks (MOFs) are promising photocatalysts, but their efficiency is often limited by rapid charge recombination. Herein, we enhance photocatalytic performance by incorporating an electron acceptor, phenyl-C<sub>61</sub>-butyric acid (PCBA), into the porphyrinic framework PCN-222 and it... |
41636618 | Silk-Nano-Fibroin Aerogels: A Bio-Derived, Amine-Rich Platform for Rapid and Reversible CO<sub>2</sub> Capture. | Despite growing interest in biobased materials, rapid, low-temperature CO<sub>2</sub> capture using amine-rich natural sorbents has received limited attention. Various porous solid sorbents have drawn significant research interest as promising carbon capture materials. However, high synthesis cost, limited CO<sub>2</su... |
41636594 | Leg Power and Velocity Predict the Risk of Major Osteoporotic Fractures (MOF): the Osteoporotic Fractures in Men (MrOS) Study. | Lower extremity muscle function has been associated with risk of falls and fractures; however, most studies have examined strength (force), but not power (force*velocity). A jump test on a force plate measures weight-bearing power and allows the dissection of peak power into its components, force and velocity. We inves... |
41636552 | A Comprehensive Review on Filled Carbon Nanotubes: Synthesis, Properties and Applications. | Carbon nanotubes (CNTs) have emerged as one of the most exciting families of carbon nanomaterials. Their hollow tubular architecture, with a nanometric inner cavity, not only defines their distinct physical and chemical behavior but also enables the encapsulation of a wide range of materials, including inorganic and or... |
41636513 | The structure of <i>Streptococcus gordonii</i> surface protein SspB in complex with TEV peptide provides clues to oral streptococcal adherence to salivary agglutinin. | <i>Streptococcus gordonii</i> is a commensal bacterium in the oral cavity and has many surface adhesins that have been well characterized. SspA/B belongs to the Antigen I/II-like family of proteins, which are well known for their multifunctional adherence capabilities. Most AgI/II-like proteins adhere to salivary agglu... |
41636454 | Porphyrinic Metal-Organic Frameworks with Longitudinal Pt Deposition Referenced as Opto/Catalytic Adjuvants for Dual-Path Glycoprotein Assay. | In this work, porphyrinic metal-organic frameworks (MOFs) with longitudinal Pt deposition were developed for the inspired establishment of opto/catalytic adjuvants referenced for a dual-path glycoprotein assay. In the compositional cooperation, porphyrinic MOFs were synthesized through Zr oxoclusters and polytopic porp... |
41636358 | Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications. | Nucleic acids are essential biological macromolecules bearing genetic information and playing important roles in post-transcriptional regulation. Given their high programmability based on Watson-Crick-Franklin base-pairing interactions, synthetic DNA and RNA oligonucleotides have become versatile building blocks for pr... |
41636339 | Single-Fiber Design for Higher Performance Artificial Muscles. | Artificial muscles are essential components in the advancement of next-generation soft robotics, biomedical devices, and adaptive wearables. While conventional fiber-based actuators often rely on multi-material assemblies and complex interfacial engineering, their performance is limited by structural heterogeneity and ... |
41636298 | Rational Design of Rigid Chiral Ir(III)-Eu(III) Dyads: Intense Circularly Polarized Luminescence via Visible-Light Sensitization. | The utility of lanthanide-based circularly polarized luminescence (CPL) probes in biological systems is frequently limited by kinetic lability and excitation-related toxicity. To overcome these barriers, we have engineered rigid chiral Ir(III)-Eu(III) dyads (<b>Ir-Eu-R</b> and <b>Ir-Eu-S</b>) using a stereoselective ″c... |
41636148 | Breaking the ORR Trade-Off via Mg-Steered Fe-N<sub>4</sub> Pyridinic Conversion. | Single-atom Fe sites coordinated by pyrrolic nitrogen (Fe-N<sub>pyrr</sub>-C) are highly active for the oxygen reduction reaction (ORR) but suffer from rapid demetalization-induced deactivation. Here, we overcome this limitation via a Mg-assisted sacrificial templating strategy that precisely reconstructs Fe-N<sub>4</s... |
41636105 | Bechgaard Salt-Like Polymers and Their Applications in Organic Electronics. | Over the last two decades, there has been substantial development in the manufacturing of nano- and micro- tubes and wires as building blocks for electronic devices, such as field-effect transistors, to complement the conventional semiconductor transistors in electronic circuits. Previous attempts to improve device per... |
41636044 | Molecular Recognition-Based Detection: Antibody Dipsticks for Cyclic Organochlorine Chemicals. | Cyclic organochlorine chemicals (COCs), including dieldrin, endrin, endosulfan, aldrin, heptachlor, chlordane, and toxaphene, persist globally as carcinogenic and neurotoxic persistent organic pollutants, posing bioaccumulation risks. In this study, we designed two haptens based on the common hexachlorocyclopentadiene ... |
41636042 | Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection. | <h4>Background</h4>Cardiovascular disease remains the leading cause of death worldwide, with coronary artery disease being the primary contributor. Our recent studies suggest that activation of LepRs (leptin receptors) in the brain can improve cardiac function after myocardial infarction. However, the mechanism by whic... |
41636020 | NH<sub>2</sub>-BDC-Pillared Ho-MOFs with/without Viologen Encapsulation: Fluorescence Sensing, Multistimulus Response, and PVDF Composite Film. | Viologen-encapsulated metal-organic frameworks (MOFs) have attracted significant interest owing to their responsiveness to multiple external stimuli, which enhances their potential applications in sensing and environmental monitoring. Here, we synthesized the novel viologen-encapsulated Ho-MOF material (pbpy)·[Ho<sub>2... |
41635977 | Nb<sub>2</sub>C-Reinforced Hydrogel Microneedle as Dual ROS-Scavenging Platform to Promote Diabetic Wound Healing. | Excessive and continuous production of reactive oxygen species (ROS) is a significant factor contributing to severe inflammation, bacterial infections, and poor angiogenesis, and it can also delay the healing of diabetic wounds. However, traditional clinical treatment methods are unable to effectively eliminate ROS. He... |
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