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41634808 | Peripheral nerve repair: innovations and future directions. | <h4>Background</h4>Peripheral nerve injuries (PNIs) remain a major clinical and socioeconomic challenge, frequently resulting in motor weakness, sensory loss, and chronic neuropathic pain that cause long-term disability and restrict daily function. Functional recovery is limited by slow axonal regrowth, Wallerian degen... |
41634505 | Nanoimprint Lithography Enabling High-Performance Organic Optoelectronics: Advances and Perspectives. | Organic optoelectronic devices demonstrate immense potential in flexible displays, wearable electronics, and artificial skin, needing precise light-field and morphology management strategies to further improve their opto-electric performance. Nanoimprint lithography (NIL) has emerged as a high-resolution, high-efficien... |
41633985 | Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING. | Cancer metastasis is the primary cause of cancer-related mortality, yet effective treatments remain limited. There is an urgent need to develop novel therapeutic strategies to combat metastasis. In this study, we demonstrate that the bacterial intracellular signaling molecule cyclic di-GMP (c-di-GMP, or cdG) exerts a p... |
41575312 | Kinetics of barrier crossing events from temperature accelerated sliced sampling simulations. | Temperature-accelerated sliced sampling (TASS) is a well-established enhanced sampling method that facilitates exhaustive exploration of a high-dimensional collective variable (CV) space through directed sampling employing a combination of umbrella restraining biases, metadynamics biases, and temperature acceleration o... |
41568407 | Photoresponsive polymersomes for nanoencapsulation of multiple cargoes as a potential theranostic strategy. | Inspired by the cell's membrane architecture, self-assembling amphiphilic copolymers in polymersomes can form biomimetic, compartmentalized, bilayered, and versatile structures through supramolecular interactions, enabling the simultaneous co-encapsulation of hydrophilic and hydrophobic cargo. This approach protects ca... |
41563318 | Host-guest interaction of NO and NO<sup>+</sup> species with calixerenes: dissecting the impact of conformational and confinement effects. | Calixarenes have emerged as a promising molecular platform for the sensing of nitric oxide (NO), due to their characteristic host-guest interaction capabilities. Understanding the noncovalent interactions present in NO-bound calixarene complexes provides valuable insight for the rational design of selective NO-binding ... |
41556595 | Supramolecular light-switchable triazole-hosts for photoresponsive anion binding. | A series of photoreversible anion binding hosts is developed, combining either an azobenzene or an arylazopyrazole as a central photoswitch unit and tetrakis-triazoles as anion binding motifs. By broad structural variations, including different linker types and positions between the triazoles, the anion binding contras... |
41890660 | A Bubble-Driven Drug Delivery System Enhances Oral Absorption and Antipyretic Efficacy of Poorly Water-Soluble Andrographolide. | <h4>Purpose</h4>While bubble-carrier systems hold great promise for enhancing the oral bioavailability of poorly water-soluble drugs, a deeper understanding of their underlying absorption mechanisms is still required. This study aimed to address this gap by developing a bubble-driven delivery system (BDDS) using the po... |
41884481 | Pharmacological Treatment for Diabetic Macular Edema: A 2025 Update on Durability and Multi-Target Therapies. | Diabetic macular edema (DME) remains a leading cause of vision loss in the working-age population, yet its management is undergoing a fundamental paradigm shift from high-frequency anti-VEGF monotherapy toward more durable and multi-mechanism therapeutic strategies. This narrative review provides an up-to-date overview... |
41798622 | DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk. | Cardiovascular diseases and brain disorders collectively represent a major global health burden. Not only do they frequently occur as comorbidities, but their pathological mechanisms are also intricately linked through a complex network of cardiovascular-brain crosstalk. Cardiovascular diseases (CVDs) and neurological ... |
41767813 | Chirality-induced stereoselective synthesis of chiral sp<sup>2</sup>-carbon-conjugated covalent organic frameworks. | A fully conjugated sp<sup>2</sup>-carbon covalent organic framework (sp<sup>2</sup>C-COF) possessing global conformational chirality holds great promise for advanced electronic devices. However, the inherent irreversibility of many reactions hinders the chirality-induced synthesis of COFs from achiral building blocks. ... |
41767580 | Analysis of <i>MIR155HG</i> gene polymorphisms and ulcerative colitis susceptibility in the Chinese Han Population. | Aberrant expression of miR-155 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), where its dysregulation may contribute to impaired intestinal barrier integrity and sustained inflammation. However, the precise role of miR-155 in the development of ulcerative colitis (UC) remains incompletely ... |
41767251 | Elucidating the mechanism of thiosulfate oxidation by a novel two-component system SulRS in deep-sea <i>Campylobacterota</i>. | Members of the phylum <i>Campylobacterota</i>, which dominate deep-sea hydrothermal vent ecosystems, typically harbor the ability for thiosulfate oxidation through a complete sulfur oxidation (Sox) system encoded by the <i>soxABXY</i> <sub><i>1</i></sub> <i>Z</i> <sub><i>1</i></sub> and <i>soxCDY</i> <sub><i>2</i></sub... |
41755819 | Screening Electrocatalysts at the Level of Kinetic Barriers under Realistic Potential and Solvation. | Kinetic barriers under realistic solvation and potential conditions, known as critical in electrochemistry in recent years, have not been widely applied in the screening of electrocatalysts, mainly due to the high computational cost. Here, we demonstrate the establishment of quantitative relations between thermodynamic... |
41752572 | Oligosaccharides Reduce the Survival of <i>Apis cerana</i> and Disrupt the Gut Symbiont <i>Gilliamella</i>. | Honeybees are vital pollinators that contribute substantially to global ecosystem stability and agricultural productivity. <i>Camellia reticulata</i>, a cross-pollinated crop species, depends on honeybees for successful reproduction. <i>Apis cerana</i> shows reluctance to pollinate <i>C. reticulata</i>, yet the molecul... |
41745656 | Intra-Rater Reliability and Construct Validity of Hand-Held Dynamometry to Evaluate the Hip Adductor Squeeze Test in Elite Youth Football Players. | Hip and groin injuries are common in elite football, and reduced isometric adductor strength has been identified as a key risk factor. Therefore, reliable and valid field-based methods for assessing hip adduction strength are essential for effective monitoring and injury prevention. This study aimed to evaluate the int... |
41744713 | Nucleic Acid-Based Field-Effect Transistor Biosensors. | The demand for rapid and highly sensitive sensing technologies is increasing across diverse fields, including precise disease diagnosis, early-stage screening, and real-time environmental monitoring. Field-effect transistor (FET)-based sensing platforms have shown tremendous potential for detecting target molecules at ... |
41737838 | Bimetallic Nanozymes/Polypyrrole/Methylene Blue Platform for Photothermal and Catalytic Biofilm Disruption and Angiogenesis Enhancement in Diabetic Wound Healing. | Diabetic wounds pose a significant challenge due to impaired tissue regeneration, prolonged inflammation, poor oxygen supply, and microbial infections. Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections delay healing by prolonging inflammation and increasing antimicrobial resistance. To develop an eff... |
41737217 | Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting. | Group A <i>Streptococcus</i> (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interve... |
41737058 | Assessing the Stability of Metal-Organic Frameworks with Local Vibrational Mode Theory. | The stability of metal-organic frameworks (MOFs) is crucial for their industrial applications, with metal-linker coordination bonds often being the weakest structural points. Here, we assessed the strength of these bonds in representative MOF series (UiO-66, MOF-5, and ZIFs) using local vibrational mode theory, which c... |
41732554 | Non-targeted screening of per- and polyfluoroalkyl substances: Advanced methods, challenges, and environmental health. | Per- and polyfluoroalkyl substances (PFAS), a class of synthetic fluorine-containing organic compounds, pose a serious threat to the ecological environment and human health due to their persistence, bioaccumulation, and extensive toxicity. Non-targeted screening (NTS) is a key method for identifying and determining unk... |
41726736 | The <i>Nitro-Chloro</i> Substitution on Two Quinolinone-Chalcones: From Molecular Modeling to Antioxidant Potential. | The increasing demand for renewable energy has driven the search for sustainable biodiesel additives whose molecular structures exhibit antioxidant potential. This study reports the synthesis and solid-state X-ray diffraction studies of two quinolinone-chalcone derivatives, C<sub>28</sub>H<sub>19</sub>N<sub>3</sub>O<su... |
41726731 | Molecular Dynamics and Quantum Chemical Insights into the Molecular Basis of Differential Toxicity of the Mycotoxin Deoxynivalenol (DON) and Its Microbial Derivatives DOM‑1 and 3-<i>epi</i>-DON. | Deoxynivalenol (DON) is a trichothecene mycotoxin from <i>Fusarium</i> species that contaminates cereal grains, posing health risks. DON binds to site A of the 60S ribosomal subunit in eukaryotes, triggering a ribotoxic stress response. Despite structural similarity, its metabolites, deepoxy-deoxynivalenol (DOM-1) and ... |
41726715 | Clove Oil-Loaded Zein Nanoparticles: Eugenol Release and Repellent Activity against <i>Sitophilus zeamais</i>. | Pest and pathogen infestations represent major challenges in agriculture, compromising crop production and grain storage, with significant economic and social impacts on food security. Nanotechnology has emerged as a promising tool for pest management through the development of nanoparticles carrying bioactive compound... |
41726675 | Transition Metal Complex Based On Phenoliccarboxylic Ligand: Spectroscopic Inspection, DFT/TDDFT Computations, Cytotoxicity and Molecular Docking Investigation. | The study was designed to explore the synthesis, characterization, and biological evaluation of a novel Mn-(II)-3-[(3-carboxy-2-hydroxyphenyl)-methyl]-2-hydroxybenzoic complex, [Mn-(CHB-2H)·4H<sub>2</sub>O)]·2H<sub>2</sub>O, in comparison to its corresponding ligand (CHB). The manganese-(II) complex (Mn-(II)-CHB) was s... |
41726674 | Integrated Experimental and Computational Insights into the Systematic Synthesis of Cyclodextrin-based MOF. | Edible cyclodextrin-based metal organic frameworks (CD-MOFs) represent a sustainable platform for green synthesis. Yet, their reproducible synthesis remains a challenge for the MOF community. In this work, we explored the reproducibility of CD-MOF synthesis and resulting structural variations through five independent s... |
41726653 | Aggregation of Graphene Flakes Under Electric Field: A Molecular Simulation Study. | Graphene flakes, as two-dimensional materials, can self-assemble under certain conditions and have wide-ranging applications in industries from electronics to biomedicine due to their exceptional mechanical, thermal, and electrical properties. Recent studies indicate that single graphene flakes can be aligned by an ext... |
41726640 | Monolithic Columns for the Isolation of Lectin: Principles, Advances and Prospects. | Cryogels are materials formed from the polymerization of monomers under freezing conditions and are mainly used as monolithic chromatography columns. Depending on the functionalization technique, they can be used for ion exchange chromatography, immobilized metal ion affinity chromatography (IMAC), hydrophobic interact... |
41717369 | Decoding the medicinal aromatic characteristic of <i>Zhuyeqing</i> and gaining new insight into sotolon. | <i>Zhuyeqing</i> is made from <i>Fenjiu</i> base liquor infused with extracts from 12 Chinese herbs. Its medicinal aroma is a unique feature of <i>Zhuyeqing.</i> However, this particular characteristic has not yet been thoroughly studied. Utilizing a normal phase liquid chromatography-sensomics-integrated strategy, we ... |
41716345 | One-step green assembly of natural polyphenol-based nobiletin nanoparticles for ulcerative colitis therapy. | Function-inspired design of natural building blocks enables engineering nanostructured particles for tailored applications. Here, a facile coordination-driven assembly of natural polyphenols was proposed for incorporating hydrophobic citrus-derived nobiletin (NOB) into the nanoparticles (NPs) via a one-pot method in aq... |
41716336 | pH-responsive printable conductive hydrogels loaded with ApoVs promote diabetic wound repair through oxidative stress scavenging and macrophage reprogramming. | Compared with normal wounds, chronic diabetic wounds involve a more complex pathological microenvironment. Cellular dysfunction, microcirculatory disorders, and high levels of oxidative stress often lead to the progression of diabetic wounds to chronic, refractory ulcers. The management of chronic diabetic wound healin... |
41716335 | A biomimetic magnetic MOF-based nanoplatform for H<sub>2</sub>S-mediated thermal re-sensitization and immune reprogramming in multimodal hyperthermia therapy. | Magnetic hyperthermia therapy (MHT) has emerged as a promising anti-cancer strategy due to its precise spatial controllability and immune-activating effects. However, tumor cells can rapidly develop thermotolerance through the upregulation of heat shock proteins (HSPs), activation of the NF-κB signaling pathway, and re... |
41710885 | Macrophage polarisation under immune regulation as a therapeutic target for tendon-bone healing: multifactorial regulation and mechanistic insights. | Recovery from a variety of surgical treatments, including arthroscopic rotator cuff repair and anterior cruciate ligament restoration, depends heavily on tendon-bone healing. There is mounting evidence that the polarisation of macrophages, namely M2 polarisation, is a crucial regulating factor in the repair of tendon-b... |
41710875 | Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice. | <h4>Objective</h4>To evaluate the synergistic immunological protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice.<h4>Methods</h4>Red blood cell-derived exosomes were loaded with 27 CD8<sup>+</sup> T-cell epitope peptides and 19 CD4<sup>+</sup> T-cell ep... |
41710403 | Fracture and mortality outcomes by osteoporosis treatment route in patients with type 2 diabetes and obesity: a propensity-matched registry study. | <h4>Purpose</h4>To evaluate the real-world effectiveness of antiresorptive osteoporosis pharmacologic treatments on fracture incidence and survival in patients with type 2 diabetes mellitus (T2DM), with subgroup analysis by treatment route.<h4>Methods</h4>We conducted a retrospective cohort study using a national regis... |
41704383 | Structure-Activity Studies on the Antitubercular Natural Product Evybactin. | The escalating threat of antibacterial resistance is a pressing global issue that highlights the urgent need for innovative antibiotics. In this regard, the recent discovery of evybactina nonribosomal depsipeptide antibiotic that selectively and effectively inhibits the growth of <i>M. tuberculosis</i>is notable give... |
41696594 | Innovative chemical design and regulation strategies for overcoming lead toxicity in perovskite-based optoelectronics: a new perspective. | The rapid rise of metal halide perovskites has revolutionized optoelectronic technologies, yet the intrinsic lead (Pb) toxicity remains a fundamental challenge threatening environmental safety and sustainable commercialization. This perspective summarizes recent advances over the past two to three years (2023-2025) in ... |
41690169 | Optimization of ultrasound-assisted extraction of Sargassum polycystum for antitumor activity: Multi-objective optimization and mechanistic insights. | This study utilizes ultrasound-assisted enzymatic extraction technology to optimize the extraction of antitumor bioactive compounds from Sargassum polycystum and evaluates their antitumor effects and mechanisms in non-small cell lung cancer. Multi-objective optimization was performed by combining response surface metho... |
41684655 | Identifying phase transitions in zeolitic imidazolate frameworks: microscopic insight from molecular simulations. | Metal-organic frameworks (MOFs) feature a rich structural diversity, including crystalline, amorphous, and liquid phases of varying topologies. Their structural characterization is often performed either at the local scale (through pair distribution functions, bond angle distributions, <i>etc.</i>) or, for crystalline ... |
41683928 | Effects of Stocking Density on Growth Performance, Physiological Responses, and Transcriptomic Profile of <i>Penaeus monodon</i>. | Stocking density plays an important role in <i>P. monodon</i> aquaculture. However, its underlying molecular mechanisms remain unknown. In this work, after a 40-day culture period, we studied the effects of different stocking densities (G1: 50, G2: 100, G3: 150 ind/m<sup>3</sup>) on <i>P. monodon</i>, assessing their g... |
41683516 | Natural Alkaloids as Antiviral Agents Against RNA Viruses: A Comprehensive and Mechanistic Review. | RNA viruses pose a persistent global threat due to their high mutation rates, zoonotic potential, and rapid adaptability. Emergence events have risen steadily, as demonstrated by major outbreaks caused by Influenza A, Ebola, Zika, and Chikungunya viruses, followed by the coronavirus epidemics of Severe Acute Respirator... |
41683509 | Chemical and Enantioselective Analysis of the Leaf Essential Oil from <i>Varronia crenata</i> Ruiz & Pav. Growing in Ecuador. | Essential oils from species of the genus <i>Varronia</i> (Boraginaceae) are recognized for their chemical diversity and biological potential; however, phytochemical information on <i>Varronia crenata</i> Ruiz & Pav. remains scarce, despite its wide distribution in the Andean region. The aim of this study was to provide... |
41683504 | Quercetin Released Biomedical Hybrid Hydrogels Fabricated by Silk Fibroin and Sodium Alginate with Incorporation of Ag@rGO Nanosheets. | The drug-encapsulated hybrid hydrogels possessed several expected properties, including porous microstructure, conductivity, adhesive strength, antioxidant activity, antibacterial properties, and cytocompatibility, and have great potential in biomedical applications, such as skin wound hydrogel dressings and bio-adhesi... |
41683342 | Xanthohumol: Mechanistic Actions and Emerging Evidence as a Multi-Target Natural Nutraceutical. | <h4>Background</h4>Xanthohumol (XN), a prenylated chalcone flavonoid derived from hops (<i>Humulus lupulus</i>), is increasingly recognized as a highly pleiotropic natural compound.<h4>Objective</h4>We aimed to structure XN's mechanistic hierarchy with emerging translational relevance across disease areas.<h4>Methods</... |
41683129 | <i>Wolffia globosa</i> as an Emerging Plant-Based Protein Source for Functional and Nutraceuticals. | <i>Wolffia globosa</i> (<i>W. globosa</i>), an edible aquatic plant of the Lemnaceae family, has gained increasing attention as a potential alternative protein and functional food ingredient due to its rapid biomass production, favorable amino acid profile, and micronutrient content. This review critically evaluates th... |
41683126 | Phytosterol Oleate Ester Replacing Cholesterol to Enhance Lutein Liposome Stability: A Mechanistic Study. | Hydrophobic bioactive compounds such as lutein exhibit poor water solubility and are prone to degradation. Liposomal delivery systems can enhance the solubility and physicochemical stability of lutein (LUT). Liposomes are primarily composed of phospholipids and cholesterol. Since phytosterol ester can reduce cholestero... |
41683120 | Optimization of Bioactive Lipid Synthesis by Enzymatic Acidolysis Using EPA + DHA Concentrate from Rainbow Trout and Tocopherols from Maqui Seed Oil. | A novel optimized bioactive lipid (OBL) rich in long-chain polyunsaturated omega-3 fatty acids (n-3 LCPUFA) was synthesized through enzymatic acidolysis using concentrated belly oil from rainbow trout (<i>Oncorhynchus mykiss</i>) (CB) and tocopherols obtained from cold-pressed maqui seed oil (<i>Aristotelia chilensis</... |
41681970 | Boron Neutron Capture Therapy: A Technology-Driven Renaissance. | Boron neutron capture therapy (BNCT) is experiencing a global resurgence driven by advances in boron pharmacology, accelerator-based neutron sources, and molecular imaging-guided theranostics. BNCT produces high linear energy transfer particles with micrometer-range energy deposition, enabling cell-selective irradiatio... |
41681452 | Development of a Mucosal Immune-Enhancing Oral Vaccine Candidate Against Porcine Epidemic Diarrhea Virus Using <i>Lactobacillus paracasei</i>. | Porcine epidemic diarrhea virus (PEDV) is a highly infectious virus that leads to severe diarrhea and high death rates in neonatal piglets. Because PEDV primarily infects the intestinal mucosa, the induction of effective mucosal immunity through oral vaccination represents a promising strategy for disease prevention. I... |
41681450 | Development and Transformation of Veterinary Experimental In Vitro Models: From 2D Culture to 3D Organoids. | In vitro models for animal experiments serve as a crucial bridge connecting basic research and clinical translation, and their developmental history profoundly reflects the paradigm shifts in life science research. This article's narrative reviews the evolutionary path from traditional two-dimensional (2D) cell culture... |
41681281 | A Comprehensive Review on Sustainable Triboelectric Energy Harvesting Using Biowaste-Derived Materials. | The growing demand for sustainable and distributed energy solutions has driven increasing interest in triboelectric nanogenerators (TENGs) as platforms for energy harvesting and self-powered sensing. Biowaste-based triboelectric nanogenerators (BW-TENGs) represent an attractive strategy by coupling renewable energy gen... |
41681272 | Radiation-Induced Synthesis of Asymmetric Porous PVDF-g-PIL Membranes via β-Cyclodextrin Leaching for Vanadium Redox Flow Battery. | This study aims to address the limitations of dense polyvinylidene fluoride (PVDF) membranes grafted with vinyl ethyl imidazole tetrafluoroborate, which exhibit low hydrophilicity and ionic conductivity in vanadium redox flow batteries (VRFBs). To improve these properties, water-soluble β-cyclodextrin was introduced as... |
41674558 | Programmable next-generation supramolecular self-assembled materials as drug delivery systems. | Supramolecular self-assembly, driven by noncovalent interactions, serves as a fundamental principle for constructing complex functional systems (biological membranes, proteins, and DNA). Inspired by these natural paradigms, biomimetic self-assembly strategies have promoted the development of drug delivery systems (DDSs... |
41671842 | A novel traditional Chinese medicine compound alleviates broiler ascites syndrome by modulating the IL-6/STAT3/FOXO3a signaling pathway. | Broiler ascites syndrome (BAS), a non-infectious group disease caused by relative hypoxia in broilers, is one of the three most serious nutritional metabolic diseases that jeopardize the chicken industry. At present, traditional Chinese medicine (TCM) is widely used to treat BAS, however, its mechanism of action remain... |
41653791 | Cauliflower-like Sn-ZnO/ZIF-67 for highly sensitive and selective NH<sub>3</sub> detection, and monitoring freshness of soy products. | Accurate detection of ammonia (NH<sub>3</sub>) is a key indicator for evaluating the deterioration of high-protein foods and is of great significance for food safety. In this study, we modified Sn-ZnO using a Co-based metal-organic framework (MOF) material (ZIF-67) to prepare cauliflower-shaped Sn-ZnO/ZIF-67 (SZZ67) fo... |
41650915 | Modulating the cytotoxic activity of Titanocene complexes through aliphatic chain modification to optimize albumin affinity. | Titanocene complexes are promising antineoplastic agents limited by poor aqueous stability. This study introduces a series of cytotoxic prodrugs designed to overcome inherent drawbacks of titanocene and its derivatives. We demonstrate that by attaching long aliphatic chains and a tridentate dipic-type ligand, we can im... |
41650822 | NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model. | <h4>Background</h4>Nuclear factor erythroid 2-related factor 2 (NRF2) regulates antioxidant defenses and protects against neurodegeneration, including Alzheimer's disease (AD). Its age-related decline disrupts redox balance and increases neuronal vulnerability, but the early hippocampal effects remain unclear. Here, we... |
41650766 | Maize starch and β-cyclodextrin nanocarriers for encapsulation of Centella asiatica polyphenols: synthesis, physicochemical properties, and pH-responsive delivery. | This study reports a novel dual-polysaccharide nanocarrier system based on maize starch (MS) and β-cyclodextrin (β-CD) for the pH-responsive oral delivery of Centella asiatica leaf polyphenols (CALE). Thus, this work reported a synergistic MS/β-CD composite nanoparticle system that integrates starch gel-network entrapm... |
41648057 | Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology. | Traditional Chinese medicine (TCM), consisting of a complete TCM diagnosis and treatment system, is a valuable treasure in the long river of Chinese clinical history. However, the subjective diagnosis, ambiguous mechanisms, and complex formulas make it slightly lag behind the development of modern medicine. With the em... |
41644049 | Distinct Proteomic and Glycosylation Signatures Differentiate A549 Tumor and BEAS-2B Nontumor Cell Line-Derived Small Extracellular Vesicles. | Extracellular vesicles (EVs) are central to intercellular communication and have gained attention as rich sources of molecular information in cancer research, but their molecular composition remains incompletely characterized. Protein glycosylation is a frequent post-translational modification; however, most EV studies... |
41643966 | Folate-conjugated chitosan/Zn-MOF for targeted 5-fluorouracil delivery in hepatocellular carcinoma. | Cancer treatment struggles with toxicity, driving the development of targeted drug delivery systems like MOFs for better efficacy and reduced side effects in hepatocellular carcinoma HCC. This study was to evaluate the anticancer efficacy and biocompatibility of formulations, Zn-MOF, Zn-MOF/5FU, and FA-Cs/Zn-MOF/5FU ag... |
41643838 | Embracing diversity: Post-translational modifications, the chaperone code, and the emergence of new chaperone entities. | Dr Len Neckers played a pioneering role in establishing that HSP90 is regulated by post-translational modifications (PTMs), fundamentally reshaping how molecular chaperones are understood. This insight laid the foundation for what has become known as the "chaperone code," the concept that coordinated PTM patterns act a... |
41643771 | Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer's disease. | Tauopathy, including Alzheimer's disease, is the most prevalent neurodegenerative disorder, yet current therapies fail to halt disease progression, partly because of limited understanding of early tau pathological structures. Cryo-EM has clarified distinct Tau structures tied to disease phenotypes but only in their mat... |
41641238 | Multiphysics-guided design of ZIF-67/MWCNT-modified electrodes for highly selective electrochemical detection of sunset yellow in complex food matrices. | The development of reliable sensing platforms for synthetic food additives remains a critical challenge due to severe matrix interferences that limit selectivity and analytical accuracy. In this work, a multiphysics-guided framework is employed to design a ZIF-67/MWCNT-modified glassy carbon electrode (GCE) for the hig... |
41640714 | Ultrasound-Activated Nanoplatform Counteracts Triple-Negative Breast Cancer via Remodeling Intratumoral Microbiota-Metabolism and Inducing Ferroptosis. | Triple-negative breast cancer (TNBC) remains therapeutically challenging owing to the paucity of broadly effective molecular targets. Piezoelectric nanomaterials that generate localized electric fields and reactive oxygen species under ultrasound (US) stimulation have emerged as a promising strategy for TNBC therapy. H... |
41637802 | Highly sensitive electrochemical sensor based on hydrazine-functionalized metal-organic framework for simultaneous determination of Pb<sup>2+</sup> and Cd<sup>2+</sup> in food and environmental samples. | Heavy metals, such as Pb<sup>2+</sup> and Cd<sup>2+</sup>, pose significant risks to human health and ecosystems due to their toxicity and bioaccumulation. This study presents a novel electrochemical sensor utilizing a hydrazine-functionalized metal-organic framework (MOF-Hydrazine) modified glassy carbon electrode for... |
41636723 | Thrombocytosis is desirable in polytrauma: Natural history and clinical outcomes. | <h4>Background</h4>Thrombocytosis in major trauma patients has been reported with equivocal clinical relevance. We aimed to describe the incidence and natural history of thrombocytosis in intensive care unit (ICU)-admitted polytrauma patients at risk of multiple-organ failure (MOF).<h4>Methods</h4>A 19-year retrospecti... |
41635109 | Tuning Circular Dichroism and Circularly Polarised Luminescence in Single Crystals of a Perylene Diimide Macrocycle. | Chiral materials that manipulate circularly polarised light have burgeoning applications across optoelectronics, sensing and information encoding, yet the functionality of organic molecular materials is often limited by their relatively low dissymmetry factors (g<sub>abs/lum</sub> < 10<sup>-</sup> <sup>2</sup>), includ... |
41635101 | Ultrasound Responsive Mn/Se-Nanozyme as PANoptosis Initiators for Bladder Cancer Immunotherapy. | Bladder cancer is a major global health challenge with high recurrence and mortality. Despite advances in surgery and chemotherapy, immune checkpoint inhibitors (ICIs) have limited effectiveness due to poor immune infiltration and inadequate responses. To address these issues, we developed an ultrasound-responsive Mn/S... |
41635091 | A Dual-Layer MOF Microneedle Patch for Self-Sensitized Mild Photothermal Therapy and Autophagy Regulation. | The integration of autophagy regulation with photothermal therapy (PTT) presents a promising therapeutic strategy for addressing triple-negative breast cancer (TNBC), a condition where current treatment modalities are hindered by limited tissue penetration and therapeutic resistance. In this study, we have developed a ... |
41635069 | Ultra-Low-Cost Hydrophobic Organic Coating for Highly Reversible Zinc Anodes. | Electrolyte additive engineering offers a promising pathway for achieving dendrite-free aqueous zinc-ion batteries (ZIBs) while facing challenges related to hydrophilic characteristics and/or high loading requirements. Herein, we developed a cost-effective and scalable facile immersion treatment to deposit a hydrophobi... |
41635045 | A Monkey-Saddle-Shaped Nanographene Embedding a Dicyclohepta[cd,fg]-as-Indacene Core and Two Additional Heptagons, and Its Paddle-Wheel Co-Assembly With Fullerenes. | We present a novel nanographene 1 that embeds a dicyclohepta[cd,fg]-as-indacene (DCH-as-I) motif and two additional heptagons. This defective π-skeleton was efficiently synthesized from the oligophenylene precursors via the Scholl reaction, affording four heptagons in one shot. The integration of DCH-as-I and heptagons... |
41635025 | A Double-Shell Hollow Hf-MOF-Driven Electrochemiluminescence Strategy for the Detection of miRNA-7. | Metal-organic frameworks (MOFs) have emerged as a promising class of luminescence emitters due to their highly tunable structures and intrinsic luminescent characteristics. In this study, a double-shell hollow Hf-MOF (DSH Hf-MOF) was prepared via a dual-template assembly. The DSH Hf-MOF with highly accessible mesoporou... |
41634937 | Controllable Silicone Rubber Curing via Controlled Release of Homogeneous Pt from a Metal-Organic Framework-Based Capsule. | Platinum-based hydrosilylation catalysts are primarily applied in the curing of silicone rubber. However, the commercial Karstedt catalysts used in industrial applications seriously suffer from rapid oxidation in air, uncontrolled activity at room temperature, rigorous storage conditions yet short pot-life, poor therma... |
41634730 | Human ES cell-derived MSC spheroids encapsulated in polydopamine nanoparticle-modified GelMA hydrogel enhance diabetic wound healing. | Mesenchymal stromal cell (MSC)-based strategies hold promises for treating diabetic foot ulcers. However, the hostile microenvironment of the lesions characterized by hypoxia, oxidative stress, and chronic inflammation impairs the survival and efficacy of transplanted MSCs. Here, we developed a composite bio-dressing b... |
41634728 | Lung cancer vaccines to enhance immune checkpoint inhibitor therapy: evidence and future perspectives. | Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of lung cancer over the past decade, markedly improving antitumor responses, overall survival, and quality of life. However, durable clinical benefit is achieved in only a subset of patients, and resistance to ICIs remains a major clinical cha... |
41634382 | CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion. | Blebs are membrane protrusions formed when localized regions of the plasma membrane detach from the actin cortex, enabling outward expansion driven by intracellular pressure. These structures play critical roles in cell migration and proliferation. While cortical actin contraction has been proposed as the primary drive... |
41634380 | SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways. | Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) is a critical cytosolic DNA sensor, whose activity can be regulated by acetylation. Here, we show that nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent lysine deacetylase SIRT4 interacts with cGAS and positively regulates innate immune responses trig... |
41634149 | Cu²⁺ as a dynamic director for Ce-incorporated (CoFeNiCuCe)₉S₈ nanoballs for multifunctional electrocatalysis. | High-entropy metal sulfides (HEMSs) have emerged as a new class of electrocatalysts, but their synthesis often faces challenges due to their inherent complexity arising from multi-metal interactions, especially with elements having large differences in atomic/ionic sizes, such as the redox-active rare-earth elements. H... |
41634111 | Chitosan-poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)-AuNPs composite for acetone detection using plasmonic image sensor. | Since acetone has more medical and industrial applications, its detection plays a significant role in indirectly measuring some quantities and controlling human safety in medical and industrial areas. In this research, a surface plasmon resonance image sensor was developed based on chitosan, poly(3,4-ethylenedioxythiop... |
41634046 | Can ferric-oxyl excited states explain elongated iron-oxygen bonds in heme peroxidase catalytic intermediates? | The use of X-ray structures to determine and interpret the ferryl iron-oxygen bond order in molecular oxygen-activating heme enzymes has, in the past, been controversial. This has mainly stemmed from the susceptibility of ferryl species to X-ray-induced electronic state changes. In this work we establishe using time-re... |
41634030 | The ppGpp-HpaR1-gum regulatory pathway modulates exopolysaccharides production in Xanthomonas campestris pv. campestris. | Exopolysaccharides (EPS) are critical components of the biofilm matrix, and ppGpp has been demonstrated to positively influence biofilm formation. Here, we elucidate the underlying mechanism by which ppGpp regulates EPS production by facilitating HpaR1 to modulate the expression of the gum cluster in the phytopathogen ... |
41634028 | Hierarchical assembly of a Ti<sub>24</sub> metal-organic polyhedron via kinetic trapping of intermediates. | The synthesis of high-nuclearity titanium metal-organic polyhedra (Ti-MOPs) has remained a formidable challenge due to the high oxophilicity and hydrolysis susceptibility of Ti<sup>4+</sup> ions. Herein, we report a Ti<sub>24</sub> MOP with a truncated octahedron (tro) topology, which represents the highest nuclearity ... |
41634025 | Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps. | The involvement of intestinal microbiota in the process of neutrophil-mediated colorectal cancer liver metastasis (CRCLM) is not yet fully understood. Here, we show that Escherichia coli (E. coli) is prevalent in CRC tissues with LM using 2bRAD-M-Seq and is linked to the release of neutrophil extracellular traps (NETs)... |
41634015 | Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. | Small interfering RNAs (siRNAs) offer significant therapeutic potential; however, extrahepatic applications, particularly to the skin, remain a challenge. Limited work has explored siRNA therapies for the skin, the largest organ in the human body, where dermatological conditions affect over one-third of the population ... |
41634007 | Molecular mechanism of phosphate import by the bacterial PstSCAB transporter. | Inorganic phosphate (Pi) is essential for all living organisms. PstSCAB, a bacterial high-affinity ABC transporter, imports Pi under limiting conditions via five subunits: PstA and PstC forming the transmembrane domain (TMD), periplasmic PstS that switches between free and TMD-docked forms for Pi capture and delivery, ... |
41634002 | Nonporous hydrophobic organic crystals for carbon dioxide capture via chain-melting phase transition. | An efficient carbon capture and release system necessitates rapid CO<sub>2</sub> transport to and from active sites, a property typically associated with permanently porous materials featuring large surface areas. Here, we present hydrophobic organic crystals of alkylated monoethanolamine that, despite their nonporous ... |
41633993 | Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry. | Bacterial cellulose possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical and healthcare applications. To address this limitation, we develop a metabolic glycoengineering-click chemistry strategy that enables in situ incorporation of azide groups into bacteria... |
41633992 | LAP2α drives breast tumorigenesis by mitigating replication stress. | Replication protein A (RPA) plays a vital role in replication stress response, with RPA-coated single-stranded DNA (ssDNA) acting as a critical platform for the coordination of the genome surveillance machinery. In previous studies, we reported that the lamin-associated protein LAP2α interacts physically with RPA, aidi... |
41633949 | Flexible-Structured Cyanine-Cyanine Conjugate Affords Highly Efficient Photothermal Therapy via Enhanced Tumor Accumulation and Heating Performance. | Simultaneous optimization of tumor accumulation and photothermal conversion efficiency (PCE) remains a major challenge in photothermal agent (PTA) development. Here, benzene-thiol/-dithio/-trithiol was introduced at the meso-position of heptamethine cyanine (Cy7) via sulfhydryl substitution. The obtained derivatives, d... |
41633929 | Influence of Sugar Headgroup on the Self-Assembly of Bioinspired Anionic Glycolipids. | In this study, we investigated the micellization of bioinspired anionic glycolipids with distinct headgroups (xylose, rhamnose, and galactose) using surface tension, small-angle X-ray scattering (SAXS), and isothermal titration calorimetry (ITC) measurements across a range of temperatures. Surface and interfacial analy... |
41633776 | RetNeXt: A Pretrained Model for Transfer Learning Across the MOF Adsorption Space. | Because of their ultrahigh porosity and tunable chemistry, metal-organic frameworks (MOFs) have emerged as leading candidates for gas adsorption applications. Nevertheless, their combinatorial nature induces a vast chemical space, challenging traditional exploration methods. In recent years, machine learning (ML) predi... |
41632934 | Light Metal Pyrazolates Grafted onto Periodic Mesoporous Silica for Carbon Dioxide Capture and Transformation. | Recent advances have shown that light metal pyrazolate complexes not only achieve high CO<sub>2</sub> uptake but are also able to convert epoxides and CO<sub>2</sub> to cyclic carbonates catalytically. Surface organometallic chemistry (SOMC) combines reactive metal complexes with the durability and robustness of a supp... |
41632881 | Efficient Implementation of the Spin-Free Renormalized Internally-Contracted Multireference Coupled Cluster Theory. | In this paper, an efficient implementation of the renormalized internally contracted multireference coupled cluster with singles and doubles (RIC-MRCCSD) into the ORCA quantum chemistry program suite is reported. To this end, Evangelista's Wick&d equation generator was combined with ORCA's native AGE code generator in ... |
41632877 | Salt-Free Glycine Electrosynthesis via Carbon-Nitrogen Coupling Boosted by the Lattice Strain in Atomically Thin <i>p</i>-Block Bismuthene. | Electrochemical carbon-nitrogen (C-N) coupling using simple inorganic feedstocks offers a sustainable route to valuable organonitrogen compounds such as amino acids. Herein, we present an atomically thin and acid-resistant <i>p</i>-block bismuthene (Bi-ene) derived via the reconstruction of a Bi-based metal-organic fra... |
41632871 | MALDI Matrix: Origins, Innovations, and Frontiers. | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and its imaging variant (MALDI-MSI) are pivotal analytical tools for biological sample analysis, allowing detection and visualization of diverse biomolecules. At the heart of MALDI-MS/MSI performance lies the crucial yet often empirically determin... |
41632817 | The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence. | Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus that can cause zoonotic disease in humans with lethal severe viral pneumonia. Dromedary camels are the source of zoonotic infection. As of November 2025, MERS-CoV has resulted in a total of 2630 reported cases, 37% of these being fatal. ... |
41632816 | ITGB1 Regulates Triple-Negative Breast Cancer Development by Modulating the Tumor Microenvironment. | Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer-immune crosstalk in the TME is imperative for developing efficacious immunotherapy. Through a series of in vivo CRISPR sc... |
41632801 | Research on the evolution of physical teachers and physical teaching policy: A perspective from China. | This study aims to comprehensively and profoundly explore the history of changes in China's physical teachers and physical teaching policies. Focusing on policies related to physical teachers and teaching published between 1950 and 2023, we employed text mining and topic-matching techniques to construct an algorithmic ... |
41632540 | Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models. | Mycobacterium tuberculosis remains a global health crisis, ranking among the deadliest infectious diseases worldwide. In response to the WHO's call for therapeutic vaccines to complement antibiotic regimens and reduce tuberculosis (TB) treatment duration, we developed an intranasal DNA vaccine fusing the M. tuberculosi... |
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