id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
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41632532 | Quadruply Bridging Strategy Intensifies Circularly Polarized Luminescence of Azapyrenophanes. | Multibridged azapyrenophanes were synthesized as organic circularly polarized luminescence (CPL) emitters. The <i>g</i><sub>lum</sub> reached +0.12 and the <i>B</i><sub>CPL</sub> amounted to 2,600 M<sup>-1</sup> cm<sup>-1</sup> at -95 °C. The xylylene-bridging to the binaphthyl-bridged pyrenophane produced a quadruply ... |
41632385 | Activating Progressive Sn<sup>2+</sup> Nucleation by Micellar Structure Electrolyte for Dead-Sn-Free Aqueous Batteries. | The instantaneous nucleation of Sn originating from the uncontrolled diffusion of Sn<sup>2+</sup> ions typically forms large, electrochemically inactive "dead Sn" that severely constraints the plating/stripping reversibility of Sn anode for acidic aqueous batteries. Herein, nanoscale spatial confinement of Sn<sup>2+</s... |
41632297 | FRET-triggered fluorescence switching: a g-CNQDs/Cu-TCPP "turn-on" aptasensor for ultrasensitive GP73 detection. | Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, and early diagnosis is crucial. Golgi protein 73 (GP73) has emerged as a promising serum biomarker for HCC. However, current detection methods often fail to meet routine screening requirements due to limitations in sensitivity and operatio... |
41632211 | Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy. | Cell therapy and oncolytic viruses have emerged as promising cancer treatments but face significant challenges in solid tumors due to immune suppression and gene-related toxicities. Here, we selected a probiotic Lactobacillus rhamnosus (LR) that appears to exert oncolytic activity by inducing massive calcium influx, wh... |
41632088 | CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity. | In vivo generation of chimeric antigen receptor-T (CAR-T) cells offers an innovative approach to CAR-T therapy; however, current in vivo CAR-T technologies rely on synthetic carriers or viral particles, which raise immunogenicity and safety concerns in clinical applications. Extracellular vesicles (EVs) are cell-derive... |
41632083 | New Fluorescent Probes, Their Spectroscopic Properties, and an Iterative Analysis of Their Complexation with Cyclodextrins. | Spectroscopic properties of a series of substituted 7-phenylamino-3-(2-pyridyl)coumarins have been characterized, and their ability to form host-guest inclusion complexes with cyclodextrins has been evaluated by the determination of the corresponding host-guest association constants. It has been found that the pyridylc... |
41632082 | Controlled Optically Active Hierarchical Nanostructures of Side-Chain Sequence-Regulated Graphene Nanoribbons. | Synthetic graphene nanoribbons (GNRs) have drawn significant attention due to their unique optical, electronic, and magnetic properties. Considerable efforts have been exerted in developing versatile synthetic methods to manipulate the architectures and properties of GNRs. However, these synthetic methodologies have st... |
41632044 | Spectral Decomposition of Chemical Semantics for Activity Cliffs-Aware Molecular Property Prediction. | Accurately predicting physicochemical and biological properties of molecules is vital for modern drug discovery, yet existing deep learning models struggle to replicate the multi-level reasoning of chemists. Relying on single molecular graphs, they fail to capture the interplay among global scaffolds, functional groups... |
41632030 | Gut Microbiota-Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol-Induced Cognitive and Social Dysfunction via CB1R-DRD2-RAP1 Signaling Axis. | Chronic alcohol consumption disrupts the gut microbiome, exacerbating alcohol-induced cognitive and social dysfunction (AICSD), which constitutes a primary etiology of early-onset dementia. Urolithin A (UA) has been well-reported as an effective intervention for neurodegenerative diseases. However, the protective effic... |
41631997 | Solution-Processed Organic Photovoltaics: Fabrication Advances and Challenges. | The growing demand for sustainable energy solutions has propelled organic solar cells (OSCs) into the spotlight as a promising alternative to traditional inorganic photovoltaics. Despite their advantages-such as lightweight, flexibility, and semitransparency-OSCs face significant challenges related to efficiency and st... |
41631887 | Cytokine-Engineered Chimeric Antigen Receptor-T Cell Therapy: How to Balance the Efficacy and Toxicity. | Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized the paradigm in hematological malignancies. However, its efficacy in treating solid tumors remains limited because the immunosuppressive tumor microenvironment (ITME) seriously blocks T cell activation, infiltration, and proliferation. Cytokines, d... |
41631850 | Broxyquinoline enhances antibacterial activity of colistin and attenuates LPS-induced inflammation. | Colistin is considered one of the last-resort antibiotics for treating infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and dissemination of mobile colistin resistance gene, <i>mcr</i>, have severely compromised the clinical utility of colistin. Combination therapy has emerg... |
41631834 | Immunostimulatory nucleic acid nanoparticles establish antiviral state to inhibit viral infection and replication. | Establishing a rapid, broad-spectrum antiviral state in human cells offers a promising strategy to combat viral infections, especially when vaccines or pathogen-specific treatments are unavailable. Here, we evaluate immunostimulatory nucleic acid nanoparticles (iNANPs), identified as potent innate immune activators, fo... |
41631773 | Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor-Associated Macrophage-Mediated Prostate Cancer Metastasis. | As one of the predominant male malignancies globally, prostate cancer (PCa) transitions to a treatment-refractory phase upon metastasis, for which no curative modalities currently exist. Tumor-associated macrophages (TAMs), a crucial component of the tumor microenvironment (TME), primarily adopt a metastasis-promoting ... |
41631766 | Modification Strategies of Carbon-Based Electrodes From Structural Regulation to Multifunctional Integration. | Carbon-based electrodes have garnered significant attention in the field of energy storage and conversion due to their excellent electrical conductivity, chemical stability, and tunable structural characteristics. This article summarizes the modification strategies of carbon-based electrodes, starting with structural r... |
41631696 | Transforming MOF Modeling with Machine-Learned Potentials: Progress and Perspectives. | Machine-learned potentials (MLPs) have emerged as transformative tools for modeling metal-organic frameworks (MOFs), bridging the accuracy of quantum mechanics with the efficiency required for large-scale molecular simulations. By learning the potential energy surface directly from quantum-mechanical reference data, ML... |
41631692 | Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns. | Mesoporous silica nanoparticles (MSNs) have garnered significant attention across various disciplines, including chemistry, physics, and materials science, owing to their distinctive properties and functionalities. Numerous studies have demonstrated that MSNs possess several advantageous characteristics, such as tunabl... |
41631555 | Theory-Guided Design of Ru-NiFe Cathode Catalysts for Anion Exchange Membrane Water Electrolysis at Large Electrode Scale. | A significant gap persists between advanced catalyst synthesis in laboratories and the industrial requirements for water electrolysis. The key challenge lies in simultaneously achieving electrode scalability, high catalytic activity, and long-term stability. Through theoretical simulation screening, we synthesized a fr... |
41631548 | Function-Oriented Modular Molecular Design of a Chitin-Derived Self-Healable Binder for Promising Zinc Powder Anodes. | Replacing zinc foil with Zn micropowders (ZnMPs) enhances manufacturing compatibility for Zn-metal batteries but imposes challenges like uncontrolled Zn deposition and accelerated structural degradation, typically resulting in a short cycle life of < 50 cycles. Herein, we synthesize a multifunctional bottle-brush polyc... |
41631454 | A Multifunctional β-Defensin-3 Mimetic Peptide Modulates Host-Biofilm Interactions and Reduces Bone Loss in Periodontitis. | <h4>Aim</h4>This study evaluated the potential of a beta-defensin-3 mimetic peptide (BDMP), a synthetic cell-penetrating peptide with antimicrobial and immunomodulatory properties, as an adjunctive therapeutic approach for periodontitis.<h4>Methods</h4>BDMP was formulated in a hydroxyethyl cellulose (HEC) gel and asses... |
41631347 | Epigenetic Metal-Organic Framework Nanoagonist Overcomes Triple Defenses to Enable Effective Chemo-Metalloimmunotherapy in Platinum-Resistant Ovarian Cancer. | Platinum-resistant ovarian cancer (PROC) responds poorly to platinum chemotherapy and evades immune surveillance by suppressing the cGAS-STING pathway, leading to poor outcomes. Herein, we developed an epigenetic metal-organic framework (MOF) nanoagonist (CMZ-Pt-SA@HA) that overcomes cisplatin (CisPt) resistance while ... |
41630044 | A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors. | <h4>Background</h4>ALK gene fusions are key oncogenic drivers in cancers such as non-small cell lung cancer, where they define a molecular subtype responsive to ALK tyrosine kinase inhibitors (TKIs). However, resistance commonly arises due to single nucleotide variants (SNVs) within the ALK tyrosine kinase domain, many... |
41629650 | Epidemiology of hip fractures in Costa Rica and development of country- specific thresholds to estimate fracture risk. | A country-specific FRAX® model for Costa Rica was developed using national hip fracture data from 2015-2019. Hip fracture incidence increased with age, was consistently higher in women, and exceeded rates reported in neighboring Latin American countries. Costa Rica also demonstrated higher 10-year major osteoporotic fr... |
41629559 | Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity. | Mechanical forces are emerging physical cues that regulate biochemical signals of immune cells for antitumor immunity. Owing to the lack of precise tools to impose intracellular forces, little is known about whether and how organelle-level forces trigger mechanotransduction for antitumor immunity. Here, we developed a ... |
41629449 | Multi-responsive, room-temperature self-healing salep-based nanocomposite hydrogels with enhanced mechanical performance as smart biomaterial. | Self-healing hydrogels are advanced materials that can restore their original functionality and properties after mechanical damage, either through intrinsic mechanisms or via external stimuli. However, their widespread application is often limited by challenges such as insufficient mechanical strength, low thermal stab... |
41603149 | Enhancing solubility and therapeutic potential of rosuvastatin via β-cyclodextrin inclusion complex-loaded chitosan nanoparticles. | Rosuvastatin is a BCS class II drug effective in the management of atherosclerosis. To enhance solubility and efficacy, Rosuvastatin-β-Cyclodextrin complex-loaded chitosan nanoparticles (R-CD-CNs) were developed. β-cyclodextrin was crosslinked with Citric acid to impart stability to the inclusion complex. Rosuvastatin ... |
41556990 | Functionalization of benzothiadiazole in magnesium-based metal-organic framework for C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> separation. | The separation of acetylene (C<sub>2</sub>H<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) is quite challenging due to their similar physical properties. Metal-organic frameworks (MOFs) have emerged as promising porous adsorbents for C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> separation, and the discovery of new frame... |
41527903 | A face-regulated tetrahedral cage for selective and efficient encapsulation of perylene dimers. | A face-capped tetrahedral metal-organic cage has been assembled from methoxy-functionalised <i>C</i><sub>3</sub>-symmetric triamines and aldehydes in the presence of Zn<sup>2+</sup> ions. This cage exhibits selective and efficient encapsulation of perylene dimers. This host-guest complex can further facilitate reactive... |
41527838 | Metal-organic frameworks for natural medicines delivery: stimuli-responsive strategies and synergistic cancer therapy applications. | Metal-organic frameworks (MOFs), as unique nanomaterials, have attracted considerable attention in the biomedical field-particularly in drug delivery systems-owing to their porous architectures and modifiable surface properties. Composed of metal ions and organic ligands, MOFs offer exceptional versatility. With the in... |
41527733 | Covalently linked rotaxane encapsulation of a benzil core for consistent organic room-temperature phosphorescence across diverse solvents. | We achieved room-temperature phosphorescence (RTP) of benzil, an aromatic diketone, in diverse solvents, as well as in amorphous solid states, by encapsulating the core with covalently linked cyclodextrins and introducing bulky capping moieties to effectively suppress intramolecular motions. |
41524151 | Supramolecular self-assembled peptide scaffolds for fluorescence enhancement and delayed emission. | Luminescent organic materials are increasingly important for applications ranging from bioimaging and sensing to optoelectronics and phototherapy. Their performance depends on controlling excited-state dynamics, yet organic luminophores face intrinsic limitations such as weak spin-orbit coupling, aggregation-induced qu... |
41510603 | Affordable, cleanroom-free millifluidic production of targeted lipid nanocarriers <i>via</i> additive manufacturing. | Lipid nanocarriers utilise the self-assembly of amphiphilic molecules to generate particle formulations capable of drug encapsulation and dynamic interactions with user-defined cell types, enabling applications within targeted therapeutic delivery. This offers increased bioavailability, stability, and reduced off-targe... |
41506784 | Transcriptomic landscape of transposable elements reveals <i>LTR7</i>-<i>PLAAT4</i> as a potential oncogene and therapeutic target in pancreatic adenocarcinoma. | Eukaryotic genomes contain numerous transposable elements (TEs), whose dysregulation threatens genome stability and may contribute to cancer. Pancreatic adenocarcinoma (PAAD) is among the deadliest cancers, marked by abundant stroma that obscures tumor-specific molecular signals, complicating bulk-tissue analyses. Here... |
41431363 | Tuning SF<sub>6</sub> affinity <i>via</i> tailoring pore environments in metal-organic frameworks. | Herein, an investigation into the impact of subtle binding site changes on SF<sub>6</sub> affinity is presented by systematically altering the pore environment of MOF-808 <i>via</i> post-synthetic modification with aryl and benzylic fluoride groups. All functionalized derivatives outperform the parent material, with ar... |
41883347 | Ultrasound-activated UiO-66 enables ROS-mediated antibacterial therapy and accelerates diabetic wound healing. | The development of noninvasive and dual-functional therapeutic strategies is of critical importance for the treatment of infected diabetic wounds, which require both effective bacterial eradication and enhanced tissue regeneration. Conventional approaches are frequently constrained by single-function modalities or adve... |
41878128 | Recent Advances in Mitochondria-Targeted Nano-Drug Delivery Systems for Cancer Therapy. | Cancer remains a major disease that poses a serious threat to human health. Conventional treatments such as radiotherapy, chemotherapy, and surgery are limited by systemic toxicity and tumor recurrence, which hinder the achievement of highly efficient and specific therapy. The development of nanodrug delivery systems h... |
41815868 | DOX-conjugated unimolecular micelles from benzaldehyde-functionalized star copolymer via metal-free ATRP for pH-responsive drug delivery. | The development of polymer prodrugs with well-defined architectures capable of forming stable nanomicelles is important for achieving precise and efficient drug delivery. Compared with conventional linear systems, star-shaped copolymer prodrugs offer enhanced micellar stability owing to their covalently tethered archit... |
41810060 | Advances in Double-Stranded DNA Targeting Technologies. | Double-stranded DNA (dsDNA) serves as a fundamental repository of genetic information and plays a pivotal role in the diagnosis and therapeutic management of diseases. However, the inherent stability of the DNA double helix under physiological conditions presents a challenge in accessing internal bases. To address this... |
41799301 | Polyoxometalates in environmental remediation and energy storage. | Over recent decades, while environmental awareness and pollution control efforts have yielded localized improvements, ongoing industrial growth, rapid global population expansion, and escalating energy demands continue to drive significant global environmental pollution challenges. Polyoxometalates, a remarkable class ... |
41794537 | Fabrication and characterization of ethyl cellulose/Zein-based multifunctional composite film integrated with cinnamaldehyde-loaded Mg-gallic acid-MOF for pork preservation. | With the escalating environmental impact of petroleum-based plastics, natural polysaccharide-protein composite films have demonstrated significant potential as eco-friendly materials for food packaging. However, research on integrating bioactive metal-organic frameworks (MOFs) with Zein-based matrices to develop multif... |
41755839 | Harnessing AI for Antimicrobial Peptide Innovation against Multidrug Resistance. | Antimicrobial resistance (AMR) poses a critical global health threat, demanding innovative strategies for drug discovery. Antimicrobial peptides (AMPs) represent promising alternatives, yet traditional experimental identification is limited by cost and scalability. Advances in artificial intelligence (AI), particularly... |
41751433 | Botanical Adjuvants in Oncology: A Review on Natural Compounds in Synergy with Conventional Therapies as Next-Generation Enhancers of Breast Cancer Treatment. | Breast cancer remains a major global health challenge despite advances in chemotherapy, endocrine therapy, targeted therapy, and radiotherapy, which are frequently constrained by therapeutic resistance, cumulative toxicity, and high costs. Accumulating preclinical and translational evidence demonstrates that plant-deri... |
41750449 | Mucoadhesive Buccal Patches Containing Resveratrol and/or Erythromycin-Loaded Lipid Microparticles as a Potential Targeted Strategy for the Prevention and Management of MRONJ in Patients Undergoing Oral Surgery. | <h4>Background/objectives</h4>Oral surgical procedures in patients at risk of/diagnosed with MRONJ require systemic antibiotic therapy, which can fail to achieve an adequate local drug concentration. This research aims to design mucoadhesive buccal patches (containing erythromycin or the erythromycin-resveratrol combin... |
41745535 | A Systematic Review on Artificial Liver for Implantation. | Chronic liver disease remains a leading cause of global mortality, yet organ shortages and transplant complications limit the efficacy of orthotopic liver transplantation. While extracorporeal support systems serve as temporary bridges, they fail to restore long-term patient autonomy or replicate complex biosynthetic f... |
41745498 | A Crown Ether-Based Covalent Organic Polymer Composite Membrane and Its Application in Molecular Separation. | Organic dyes are critical components in industries ranging from textiles, plastics, and paper to food, cosmetics, and pharmaceuticals. However, their widespread use leads to significant environmental pollution. Consequently, developing efficient methods to treat dye wastewater is urgently needed. In this work, a high-p... |
41745010 | Design and Application of Stimuli-Responsive Hydrogels for 4D Printing: A Review of Adaptive Materials in Engineering. | Stimuli-responsive hydrogels are an emerging class of smart materials with immense potential across biomedical engineering, soft robotics, environmental systems, and advanced manufacturing. In this review, we present an in-depth exploration of their material design, classification, fabrication strategies, and real-worl... |
41745005 | A De Novo Sacrificial-MOF Strategy for Fabricating Cellulose Nanofibers/ZIF-8/PANI Gel Composite Membranes for High-Performance Flexible Supercapacitors. | Cellulose nanofibers/metal-organic framework (CNFs/MOF) composites hold promise for energy storage thanks to high porosity, large specific surface area, and inherent flexibility, but their poor conductivity limits applications to environmental remediation and gas adsorption. Herein, flexible CNFs served as substrates f... |
41744711 | Wearable Sensors for Health Monitoring. | The growing global population and the rapid increase in older adults are driving healthcare costs upward. In response, the healthcare system is shifting toward models that enable continuous monitoring of individuals without requiring hospital admission. Advances in sensing technologies, embedded systems, wireless commu... |
41744710 | Recent Advances in Electrochemical Biosensors for the Detection of Milk Adulterants. | The precise and reliable detection of milk adulterants has garnered increased scientific interest owing to the rising incidence of food fraud. Recent years have witnessed substantial advancements in optical and electrochemical biosensors for the quick, sensitive, and on-site determination of adulterants. This review th... |
41744712 | A Comprehensive Review of Biochemical Insights and Advanced Packaging Technologies for Shelf-Life Enhancement of Temperate Fruits. | Temperate fruits, mostly comprising pome, stone fruits, and berries with immense nutritional benefits and a storehouse of various therapeutic phytochemicals, are prone to several physiological disorders immediately after harvest. The etiology, symptom progression, and decay incidence are influenced by pre-harvest and p... |
41737839 | Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors. | The emergence of effective immunotherapies has drastically revolutionized clinical management of many cancer types. Among them, chimeric antigen receptor (CAR)-T cell therapy (CTT), as a groundbreaking approach, has been considered as a "living drug," displaying unprecedented clinical outcomes with hematological malign... |
41732506 | Anthocyanins from fruit and vegetable waste: biosynthesis, extraction, and gut health benefits. | Anthocyanins (ANCs), naturally abundant in fruit and vegetable waste, represent a promising class of sustainable functional ingredients with notable gut-related health benefits. This review uniquely focuses on waste-derived anthocyanins and their microbiome-modulating effects, including enhancement of intestinal barrie... |
41732272 | Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer. | Cancer cell metabolic re-programming provides the additional energy and anabolic precursors necessary to sustain unregulated proliferation. This is partially mediated by the Warburg effect, which generates ATP while oxidizing glucose to a subset of these anabolites. Concurrently, mitochondrial mass and ATP generation v... |
41726735 | Exploring the Impact of Electric Field and OLi<sub>3</sub> Decoration on Inorganic Graphenylene SiC for Reversible Hydrogen Storage: A First-Principles Investigation. | The hydrogen storage capacity of superalkali OLi<sub>3</sub>-decorated inorganic graphenylene SiC (IGP-SiC) has been explored using first-principles calculations employing the GGA-PBE functional. Notably, OLi<sub>3</sub> is found to be strongly bonded to the IGP-SiC monolayer with a binding energy of -3.89 eV. Thus, a ... |
41726623 | Integrating Metal-Organic Frameworks with Antimicrobial Peptides: Advances and Challenges in Antibacterial Therapeutics. | The widespread presence of pathogenic microorganisms poses significant threats to human health. While antibiotics remain a powerful tool in combating bacterial infections, their overuse has accelerated the emergence of antibiotic-resistant strains, leading to a global health crisis. Antimicrobial peptides (AMPs), a cla... |
41726598 | Cellulose Nanofibrils from Black Wattle (<i>Acacia mearnsii</i> De Wild.) Residues Produced by High-Intensity Ultrasonication: Production and Characterization. | This study investigates the production of cellulose nanofibrils (CNF) from black wattle bark residues using high-intensity ultrasound (HIUS) as an environmentally friendly mechanical process. The residues were subjected to alkaline delignification and bleaching to obtain cellulose microfibers (CMF), which were subseque... |
41726161 | Decoding the impact of nsSNP variants on BCL6 function through integrated computational analysis. | BCL6 plays significant roles in various cellular processes and malignancies such as diffuse large B-cell lymphoma. BCL6 performs its functions through binding of its BTB domain to different corepressors. Thus, analyzing the possible structural consequences of nsSNPs on the function of this domain would be imperative. T... |
41716952 | Rutin outperforms gallic acid in mitigating carbon tetrachloride-induced nephrotoxicity: Integrated in silico (docking, MD simulations, DFT) and in vivo mechanistic validation. | <h4>Background</h4>Carbon tetrachloride (CCl₄) induces nephrotoxicity via oxidative stress and inflammation.<h4>Aim</h4>This novel comparative study evaluated the nephroprotective efficacy of rutin and gallic acid (GA) against CCl₄-induced kidney damage by elucidating their antioxidant and anti-inflammatory mechanisms.... |
41708240 | ·ATP-enhanced PB@MIL-100(Fe) nanozyme enables dual-mode ratiometric colorimetric and smartphone-based hydrogel detection of nitrite in food samples. | <h4>Background</h4>Nitrite residues pose significant threats to food safety, as excessive consumption of this may cause serious health risks to human. Conventional techniques such as Griess reagent and chromatographic methods can successfully quantify nitrite levels, but these approaches often suffer from complex sampl... |
41705242 | Neuroinflammatory regulatory role of microglia in optic nerve injury: from pathological mechanisms to therapeutic targets. | Optic nerve injury, encompassing conditions such as glaucoma, optic neuritis, and traumatic optic neuropathy, is a major cause of irreversible vision loss. Traditional broad-spectrum anti-inflammatory treatments have shown limited efficacy, highlighting the need for precision-based therapeutic approaches grounded in th... |
41704850 | The anti-biofilm compound 4-ethoxybenzoic acid inhibits <i>Staphylococcus aureus</i> virulence factor production via a putative 4EB-binding pocket in key virulence-associated proteins. | There is a need for dual action anti-virulence and anti-biofilm agents that target the opportunistic pathogen <i>Staphylococcus aureus</i>. Previous research determined that 0.8 mg/mL 4-ethoxybenzoic acid (4EB) reduced <i>S. aureus</i> ATCC 6538 biofilm formation by 88% relative to untreated controls with moderate inhi... |
41704643 | Computational identification of natural inhibitors targeting GroEL in <i>Leptospira interrogans</i>: an integrative virtual screening and molecular dynamics approach. | <h4>Introduction</h4>Leptospirosis is a zoonotic disease caused by <i>Leptospira interrogans</i> and represents a major public health and veterinary concern. The persistence of the pathogen is closely associated with biofilm formation, yet targeted therapeutics are currently unavailable. The GroEL chaperonin, a conserv... |
41704535 | VNAR: shark single-domain antibodies for the new era of medical biotechnology. | Shark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to traditional antibodies, making them valuable tools for next-gener... |
41685368 | Triple-emulsion microfluidic Core-Shell hydrogel microcapsules for oral pentoxifylline Delivery: Ameliorating colitis and rebalancing gut microbiome. | <b>Inflammatory bowel disease (IBD) encompasses chronic or relapsing inflammation within different regions of the gastrointestinal tract. Pentoxifylline (PTX)</b>, a methylxanthine derivative primarily used to improve blood flow in peripheral vascular diseases, has demonstrated anti-inflammatory and immunomodulatory pr... |
41684651 | 3D self-assembly of cyclic peptides into multilayered nanosheets. | The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows... |
41683908 | Nodule-Microbiome Dynamics: Deciphering the Complexities of Nodule Symbiosis and the Root Microbiome. | Microbiomes play a pivotal role in sustaining plant function and broader ecosystem processes. Leguminous plants host vast populations of intracellular bacteria within specialized root organs known as nodules. The intricate mutualism between legumes and rhizobia ensures a stable supply of biologically fixed nitrogen (N)... |
41683902 | Functional Characterization of <i>Eccyp307a1</i> in Early Ovary Development of <i>Exopalaemon carinicauda</i>. | According to a previous study, in insects, <i>cyp307A1</i> plays a central role in ecdysteroid synthesis, which is a member of the cytochrome P450 family. However, the function of <i>cyp307A1</i> in crustaceans remains unclear. In this study, we explored the function of <i>Eccyp307a1</i> in <i>Exopalaemon carinicauda</... |
41683500 | Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology. | DNA and RNA, by focusing on their unique molecular properties, have transcended their role as carriers of genetic information in life and pioneered new application fields such as molecular robotics and molecular computing. However, as these technologies advance, the limitations inherent in natural nucleic acids and the... |
41683494 | Antimicrobial Peptide Nanoassemblies: Design, Response Mechanisms, and Biomedical Applications. | The overuse of antibiotics has accelerated the evolution and mutation of drug-resistant bacteria, creating an urgent need for novel antimicrobial drugs and feed additives. Antimicrobial peptides, with their unique membrane-disrupting mechanism that resists the development of resistance, hold promise as antibiotic alter... |
41683491 | DNA Nanostructure-Assembled Metallic Nanoparticles for Biosensing Applications. | DNA nanotechnology offers an unprecedented level of structural programmability for organizing metallic nanoparticles into precisely defined architectures, providing a powerful platform for plasmonic biosensing. In particular, gold and silver nanoparticles assembled on DNA nanostructures enable nanometer-scale control o... |
41683490 | The Preparation and CO<sub>2</sub>-Resistant Performance of a Smart Responsive Polymer Gel for CO<sub>2</sub> Flooding Channel Blocking. | CO<sub>2</sub> flooding is an effective technique for enhancing oil recovery in low-permeability reservoirs. However, it is often hindered by severe CO<sub>2</sub> channeling. This challenge is particularly pronounced in near-wellbore regions with large pressure differentials and in fractured reservoirs, where high CO<... |
41683487 | Targeting Triple-Negative Breast Cancer: A Special Focus on Phototherapy and Nanomaterials. | Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking estrogen, progesterone, and HER2 receptors. This characteristic limits the effectiveness of hormonal and targeted therapies, and despite advances in chemotherapy (ChT), radiotherapy (RT), surgery, targeted therapy (TT) and immunother... |
41683482 | Functional Properties of Chitosan Conjugated with Oleic Acid and Caffeic Acid and Its Application in Oil-in-Water Emulsions. | The objective of this study was to develop multifunctional chitosan (CT) derivatives by conjugating oleic acid (OLA) and caffeic acid (CAF) to improve water solubility at neutral pH, enhance interfacial activity, and provide antioxidant protection in oil-in-water emulsions. Two CAF-incorporation strategies-1-(3-dimethy... |
41683107 | Eco-Friendly Sample Preparation Trends for Exogenous Toxic Organic Compounds in Food: A Sustainable Perspective for LC-MS Analysis. | Exogenous toxic compounds in foods, arising from agricultural practices, environmental contamination, industrial processing, and packaging migration, remain a major global concern for food safety. These contaminants include mycotoxins, veterinary drug residues, antibiotics, pesticides, per- and polyfluoroalkyl substanc... |
41682474 | Recent Advances in Metal-Organic Frameworks for Gas Sensors: Design Strategies and Sensing Applications. | Gas sensors are essential in areas such as environmental monitoring, industrial safety, and healthcare, where the accurate detection of hazardous and volatile gases is crucial for ensuring safety and well-being. Metal-organic frameworks (MOFs), which are crystalline porous materials composed of metal nodes and organic ... |
41682102 | Sustainable Thin-Film Composite Mixed-Matrix Membranes Based on Cellulose Acetate, Bimetallic ZIF-8-67, and Ionic Liquid for Enhanced Propene/Propane Separation. | Efficiently separating propene and propane is paramount for the chemical industry but notoriously difficult due to their minimal size and volatility differences. Here, an efficient strategy to overcome this separation challenge was demonstrated through the design of bimetallic zeolitic imidazolate framework (ZIF)-based... |
41681448 | Comparative Mitogenomics of <i>Channa pyrophthalmus</i> Unveils Orogeny-Driven Speciation and Lineage-Specific Adaptive Evolution in Snakeheads. | Snakeheads of the genus <i>Channa</i> display remarkable diversity in body size and ecology, yet evolutionary relationships within several species complexes remain unresolved. <i>Channa pyrophthalmus</i>, a recently described dwarf species endemic to Myanmar, represents a key lineage for investigating allopatric divers... |
41681271 | Porous Si-Based Materials for Lithium-Ion Battery Anodes: Structural Design and In Situ/Operando Characterization. | Silicon is a well-known anode material for lithium-ion batteries that has attracted a lot of interests because of its high theoretical specific capacity (4200 mAh g<sup>-1</sup>). However, its severe volume expansion during cycling leads to structural degradation and rapid capacity fading. The design of porous silicon ... |
41681264 | Synthesis of New Volatile Derivatives of Biogenic Amines, Carbamates for Analytical Applications. | In this study, a comprehensive derivatization strategy for biogenic amines based on the formation of volatile carbamate derivatives using 2,2,2-trifluoroethyl chloroformate (TFECF) was successfully developed and evaluated. A series of biogenic amine derivatives was obtained in excellent yields (94-99%) and structurally... |
41677546 | Metal-Organic Framework-Based Fluorinated Carbon for Li Primary Battery. | Li/fluorinated carbon (CF<sub>x</sub>) batteries have attracted considerable attention in the field of energy storage owing to their excellent energy density and long storage life. However, the development of CF<sub>x</sub> cathodes is restricted by their poor conductivity at high degrees of fluorination. Herein, ZIF-8... |
41676076 | Polystyrene-bound thioxanthone - a heterogeneous photocatalyst for alcohol oxidation <i>via</i> singlet oxygen production. | We have synthesized a photocatalyst in which thioxanthone is covalently attached on a polystyrene (<b>TX@PS</b>) polymer and investigated its activity in the photocatalytic oxidation of alcohols to aldehydes. Upon LED irradiation (405 nm), benzyl alcohol is converted to benzaldehyde at a yield of 73% and hydroxymethylf... |
41675424 | Beyond 800 nm: recent progress in high-performance near-infrared thermally activated delayed fluorescence based OLEDs. | Near-infrared (NIR) thermally activated delayed fluorescence (TADF) materials with emission peaks beyond 800 nm have attracted considerable attention owing to their potential applications in bioimaging, optical communication, and night-vision technologies. However, their development remains limited by the energy gap la... |
41675231 | Reconstructing the hydrogenobyrinic acid synthetic toolkit by combining cell-free systems and metabolic engineering. | Hydrogenobyrinic acid (HBA) is a pivotal intermediate in the aerobic biosynthesis of cobalamin (vitamin B12), representing a stable, metal-free corrin precursor and a useful substrate for both biological and chemical derivatization. Despite its significance, efficient HBA production remains limited by the complexity of... |
41657655 | Pd-catalyzed stereoretentive synthesis of reversed <i>C</i>-acyl glycosides: access to rare l-sugars and higher-carbon sugars. | Reversed <i>C</i>-acyl glycosides represent a versatile class of nonclassical glycosides with potential in complex carbohydrate synthesis, including l-sugars, higher-carbon sugars, and medicinal chemistry. Conventional strategies for l- and higher-carbon sugars are limited by multi-step protection-deprotection sequence... |
41657651 | Positioning versatile inorganic cathode materials in the aqueous zinc-ion battery landscape. | Rechargeable aqueous zinc-ion batteries (AZIBs) have attracted great attention due to their inherent advantages such as high safety, low cost, and environmental friendliness, making them one of the most promising alternatives to traditional lithium-ion batteries. The rational design and continuous optimization of versa... |
41655527 | Dual heterojunction engineering in SiC/Ni-MOF derivative hybrids for boosting photocatalytic CO<sub>2</sub> reduction with H<sub>2</sub>O. | Heterojunction construction has been widely regarded as a pivotal strategy for enhancing photocatalytic CO<sub>2</sub> conversion of Ni-MOF and employing the post-synthetic modification (PSM) strategy can further improve the electron transport efficiency and increase the reaction active sites of MOF-based materials. He... |
41653776 | Discovery of novel structural imidazolylvinylquinolones exerting excellent broad-spectrum antibacterial efficacy with multitargeting potential. | A unique type of imidazolylvinylquinolones (IVQs) as novel structural scaffold were developed which afforded excellent broad-spectrum antibacterial efficacy with multitargeting potential. Most of the prepared IVQs gave high antibacterial activity and broad antibacterial spectrum, and especially ethyl IVQ 14a, in which ... |
41650719 | Clonal hematopoiesis and age-associated degenerative disorders. | Clonal hematopoiesis (CH) is increasingly recognized not only as a predisposing factor for overt hematologic malignancies but also as a contributor to cardiovascular, metabolic, and other age-associated degenerative and inflammatory disorders. These associations likely arise from complex heterotypic interactions betwee... |
41650636 | Stage-specific transcriptional atlas of goose satellite cells uncovers molecular dynamics driving embryonic skeletal muscle development. | Muscle development in goose embryos is a complex and highly coordinated process involving dynamic morphological and transcriptional changes. Skeletal muscle satellite cells (SMSCs) play essential roles in postnatal muscle growth, regeneration, and meat quality, yet the molecular mechanisms regulating SMSC behavior duri... |
41650591 | A superoxide anion-responsive supramolecular polymer from peptide-H<sub>2</sub>S donor conjugates for preventing liver ischemia-reperfusion injury. | Liver transplantation is the ultimate therapeutic intervention for patients with end-stage liver diseases. However, hepatic ischemia-reperfusion injury (HIRI) could occur and influence the success of transplantation and postoperative patient survival rates. Although there are several treatments available alleviating th... |
41650556 | Ultra-sensitive Fiber-OECT biosensor enabled by ZIF-67/f-MWCNT for noninvasive urea monitoring. | Urea is a key biomarker for diagnosing various kidney and liver disorders, which can be assessed through sensing platforms. However, existing urea sensors have performance issues in real samples. Herein, a novel fiber-organic electrochemical transistor (F-OECT) sensing platform was constructed by sequentially depositin... |
41643523 | The application of MOF-based drug delivery systems in tumor immunotherapy. | Tumor immunotherapy demonstrates considerable promise in activating the body's immune system. Nonetheless, the tumor microenvironment presents a significant challenge to the efficacy of this therapy. Metal-organic framework compounds (MOFs) possess substantial potential for clinical application in tumor immunotherapy, ... |
41641009 | Glucocorticoid-dependence and independence of the circadian liver transcriptome. | The liver, a key metabolic organ, shows clear day-night variation in gene and protein expression, and in metabolic pathway activity. Liver cells possess molecular circadian clocks, but systemic factors are critical contributors to the circadian rhythmicity of liver gene expression. Glucocorticoid action is reported to ... |
41641007 | Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug-Resistant Strains of <i>Pseudomonas aeruginosa</i>. | <h4>Introduction</h4><i>Pseudomonas aeruginosa</i> is a leading cause of severe nosocomial infections worldwide. This opportunistic pathogen is associated with increased morbidity and mortality rates due to its high levels of antibiotic resistance. The identification of novel therapeutic targets is therefore a pressing... |
41640993 | A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights. | Traditional Chinese medicine (TCM) has garnered considerable attention due to its multifaceted therapeutic potential, characterized by a broad spectrum of pharmacological activities, multiple biological targets, and a generally favorable safety profile. Atractylone, a bioactive sesquiterpenoid, has been noted to exhibi... |
41640674 | Engineering scalable vascularized kidney organoids for in vivo glomerular filtration with human endothelial integration. | Kidney organoids derived from human pluripotent stem cells have emerged as promising models for studying kidney disease and therapeutic development. However, the lack of a scalable production system has limited their industrial applications in regenerative medicine. Here, we have developed a cost-effective mass-product... |
41640456 | Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application. | Cancer is a complex disease characterized by systemic dysfunction, necessitating a balance between therapeutic efficacy and safety. Immunotherapy is a core treatment approach for activating the antitumor immune response in the human body. The development of intelligent hydrogels has provided an innovative platform for ... |
41638431 | Cosolute effects reveal the nature of weak forces governing GLP-1 oligomer stability. | Glucagon-like peptide-1 (GLP-1) is an incretin hormone widely used to manage diabetes and obesity through its ability to regulate glucose homeostasis. Clinically relevant GLP-1 sequences form oligomeric states. Uncontrolled oligomer formation can drive fibril formation, posing challenges, such as difficulty in controll... |
41638330 | Dual MOFs-Derived CdS/In<sub>2</sub>S<sub>3</sub> heterojunction photocatalyst for fast and efficient reduction of Cr(VI). | Traditional methods for treating Cr(VI)-containing wastewater often encounter issues such as high energy consumption, susceptibility to secondary pollution and limited treatment efficiency. In contrast, photocatalytic technology harnesses solar energy to efficiently reduce Cr(VI) to less toxic Cr(III) under mild condit... |
41638275 | Structure-guided rational design of ferritin nanocages unlocks thermoresponsive channels for accelerated drug encapsulation. | Human ferritin heavy chain (HFn) nanocages are attractive biological macromolecular carriers for glioblastoma therapy owing to their intrinsic biocompatibility, well-defined cage-like architecture, and transferrin receptor 1 (TfR1)-mediated blood-brain barrier penetration. HFn nanocages possess intersubunit channels th... |
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