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41637803 | Constructing a composite interface on in situ grown MOF scaffolds for efficient separation of D,L-amino acids via chiral ligand-exchange capillary electrochromatography. | The inherently low phase ratio and limited surface capacity of open-tubular capillary electrochromatography (OT-CEC) significantly restrict its efficiency in enantioseparation. To overcome this limitation, we developed a rigid-flexible composite interface strategy to construct a high-efficiency chiral ligand-exchange C... |
41635914 | Allosteric ligand-aptamer complexes orchestrate supramolecular or transient catalytic, transcription and fibrinogenesis processes. | Allosteric regulation, the modulation of biological macromolecular function through binding of molecules at distant sites distinct from the active site, is a fundamental principle in biology that governs enzyme activity, signaling, and gene expression. In this work, we present allosteric ligand/aptamer complexes, coupl... |
41635764 | Recent advances in the synthesis of α-dystroglycan <i>O</i>-mannose glycans. | α-Dystroglycan (α-DG) is an important component of the extracellular domain of the dystrophin complex, with extensive and diverse <i>O</i>-mannosylation modifications, which can widely participate in various physiological and pathological processes. In particular, core M1, core M2, and core M3 <i>O</i>-mannose glycans,... |
41635761 | A near-infrared-controlled and logic gate sensing platform for the sensitive and specific detection of dual miRNAs. | Early detection of endometrial cancer remains challenging because of the lack of sensitive and specific diagnostic methods. This study develops a near-infrared (NIR)-activatable sensing platform with an AND logic gate to simultaneously detect miR-21 and miR-155, two promising endometrial cancer biomarkers. The sensing ... |
41635756 | Functionalized poly(glycidylmethacrylate) for selective uranium(vi) adsorption: experimental and theoretical calculation insights. | This study investigates the recovery of uranium(vi) using a novel functionalized polyglycidyl methacrylate (PGMA) adsorbent, PPA-PGMA, modified with polyamine-phosphonic acid. The adsorbent's structure was confirmed by CHNP, BET, SEM, TGA, XRD, XPS, and FTIR analyses. Batch adsorption studies from synthetic solutions r... |
41635086 | In vivo production of an anti-HIV antibody in mice by non-viral gene knockin in primate hematopoietic stem and progenitor cells. | Gene editing strategies that do not rely on viral vectors are being explored for their potential to support durable biologics production. While clinical trials have shown that adeno-associated virus encoding broadly neutralizing antibodies can protect against HIV, these interventions often yield limited, short-lived re... |
41633357 | Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections. | Evolution of SARS-CoV-2 in long-term persistent infections is hypothesized to be a major source of variants of concern (VOCs). However, linking intra-host variants into haplotypes that reflect viral subpopulations is limited by commonly used genomic sequencing techniques. We develop sequencing and analysis methods for ... |
41633237 | A dual-mode sensing strategy for the detection of Malathion based on bimetallic nanozymes coupled with aptamers. | Malathion (MLT) is an organophosphate insecticide with well-defined toxicity to the human body. Both short-term exposure to high doses and long-term exposure to low doses can impair human health. In this study, we developed a novel colorimetric and photothermal method for the detection of MLT using aptamer (Apt)-conjug... |
41630561 | Oxygen-Independent Mineralization of Acetaldehyde by a Cyclodextrin-Anchored WO<sub>3</sub> Photocatalyst under Visible Light. | Photocatalytic degradation of volatile organic compounds (VOCs) using visible light has been widely investigated, but its practical implementation remains constrained by several limiting factors. Here, we prepared carboxymethyl-β-cyclodextrin (CMCD)-anchored WO<sub>3</sub> that enabled visible-light-driven mineralizati... |
41630196 | Potent, Selective, and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability. | Neuronal nitric oxide synthase (nNOS) is a therapeutic target for the treatment of various neurological disorders and for melanoma. As part of our ongoing efforts to develop potent and selective nNOS inhibitors, we modified our previously reported compound <b>3</b> to <b>4</b> by introducing an ether linker, leading to... |
41630127 | Heavy is the Crown: Crown Ether Modulation of Cobalt Porphyrin CO<sub>2</sub> Electroreduction in Zero-Gap Electrolyzers. | Since decades, metalloporphyrins have been studied to catalyze the electrochemical CO<sub>2</sub> reduction (eCO<sub>2</sub>R) with the most recent studies focusing on immobilized complexes aiming for heterogeneous, scalable catalysis. However, reports for the application in industrially relevant zero-gap type electrol... |
41630025 | Genomic epidemiology and aztreonam-avibactam resistance mechanisms of Proteus mirabilis in china: an eight-year retrospective study. | <h4>Background</h4>Proteus mirabilis has emerged as an important multidrug-resistant opportunistic pathogen, with the production of metallo-β-lactamases (MBLs) being a major contributor to its broad-spectrum resistance. Although the aztreonam-avibactam (ATM-AVI) combination represents a key therapeutic option against M... |
41629977 | Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses. | Temporary amelioration of immunosuppression following extrinsic stress-induced immunogenic signal release provides opportunities for immunotherapy improvement. However, therapeutics that fail to translate local stimulatory clues into ongoing systemic antitumor responses would in turn hijack the alleviated immune status... |
41629951 | Logic-gated fluorescent biosensor integrating aptamer recognition and oxidative cleavage-responsive DNA circuit for myeloperoxidase detection. | <h4>Background</h4>Precise discrimination between protein abundance and catalytic activity of proteases remains a critical yet challenging objective in biomedical diagnostics due to overlapping biological functions, intricate regulatory mechanisms, and extensive interference from endogenous biomolecules.<h4>Methods</h4... |
41629930 | ROS-responsive nanoliposomes loaded with anti-oomycetes medium-chain fatty acids for shuttling delivery in plant disease control. | <h4>Background</h4>2E,4E-decadienoic acid (DDA) is an aliphatic compound with potent anti‑oomycete activity against Phytophthora nicotianae (Pn), a plant pathogen responsible for major agricultural losses. Mechanistic studies revealed that DDA targets mitochondria and requires intracellular delivery to exert its activi... |
41629825 | GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses. | <h4>Background</h4>Sepsis, a life-threatening inflammatory syndrome with incompletely understood genetic mechanisms, necessitates identification of pathogenic proteins to advance precision medicine. This study integrated Mendelian randomization (MR) and multi-omics analyses to systematically investigate causal proteins... |
41629787 | Sugammadex and intraocular pressure: systematic review with meta-analysis and trial sequential analysis. | <h4>Background</h4>Elevated intraocular pressure (IOP) during emergence from general anesthesia may precipitate visual complications, particularly in patients with predisposing ocular conditions. Anticholinergics used with neostigmine for neuromuscular blockade reversal can transiently increase IOP, whereas sugammadex ... |
41629739 | Lufenuron Dual-Carrier Nanoformulation: Controlled Release and Systemic Translocation viaβ-Cyclodextrin Octadecanoate and Urea-Formaldehyde Resin. | Through dual encapsulation of the insecticide lufenuron with β-cyclodextrin octadecanoate and urea-formaldehyde resin, a lufenuron@β-cyclodextrin octadecanoate/urea formaldehyde resin (LF@β-CDs/UF) nanoformulation was prepared. This dual-carrier synergy significantly prolonged the release cycle of lufenuron and enhance... |
41629626 | Evolution of intrinsically disordered regions in vertebrate galectins for phase separation. | Intrinsically disordered regions (IDRs) are widespread in proteins, yet their evolutionary paths remain poorly understood. Using galectin, a universal carbohydrate-binding protein, we investigated how IDRs evolved and acquired their biological roles in vertebrates. Through extensive proteome-wide sequence analyses, we ... |
41629604 | The filamentous ultrastructure of the PopZ condensate is required for its cellular function. | Biomolecular condensates have key roles in regulating cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We studied this relationship using the polar organizing protein Z (PopZ). Here, we revealed hierarchical assembly of PopZ into a filamentous condensa... |
41629527 | M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans. | The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The localization determinants of this machinery remain poorly characterized. Here, we report that in human cells, artificia... |
41629525 | Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity. | Anti-major histocompatibility complex class I (MHC-I) mAbs can stimulate immune responses to tumors and infections by blocking suppressive signals delivered via various immune inhibitory receptors. To understand such functions, we determined the structure of a highly cross-reactive anti-human MHC-I mAb, B1.23.2, in com... |
41629496 | Ferritinophagy: molecular mechanisms and its crosstalk with ferroptosis in chronic respiratory diseases. | Ferritinophagy, a selective autophagic process mediated by nuclear receptor coactivator 4 (NCOA4), plays a central role in maintaining cellular iron homeostasis by degrading ferritin and releasing stored iron. Under physiological conditions, this process dynamically regulates iron storage and utilization, thereby preve... |
41629448 | Computational epitope heterogeneity analysis in immunostainings from antibody-dilution series. | Antibodies are widely used in life sciences and medical therapy. Broadly applicable methods to determine epitope heterogeneity in immunostaining systems are missing. Here, we present a simple-to-use approach to characterize and quantify antibody binding properties that constitute the staining directly in the system of ... |
41629350 | van der Waals grain boundaries with inert electrical behaviors in inorganic molecular dielectric film. | Grain boundaries (GBs) in insulating crystal films generally create lattice reconstruction and excess mid-gap states, which may form the transport pathways of charge carriers and lead to serious degradation of insulating properties. Here, we reveal the inert electrical behaviors of GBs in polycrystalline inorganic mole... |
41629349 | The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects. | Gut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by inducing ubiquitin-proteasome system (UPS)-mediated degradation of the ... |
41629353 | Inhalable herbal nanotherapeutics targeting lung carcinoma. | Targeted cancer therapy promises high local drug exposure, superior efficacy and minimal hazards. Myricetin (MYR) flavonoid exhibits distinct apoptotic and antiproliferative effects on lung carcinoma. However, limited solubility and bioavailability restricted its biomedical application. Attempt for dual targeting relie... |
41629347 | Coacervate droplets as pH-regionalized protocells. | The mechanisms governing pH regulation in membrane-less organelles (MLOs) are essentially different from those relying on membrane proteins, yet it remains poorly understood due to the difficulty in directly controlling the conditions across the MLOs interface. Here, we develop a coacervate-based, in vitro model to inv... |
41629320 | An insect-scale artificial visual-olfactory bionic compound eye. | Compound eyes feature unique optical structures and high-efficiency image processing. The opto-olfactory nervous system of Drosophila has the characteristics of lightweight and low power consumption. Significant efforts have been dedicated to the design and manufacturing of artificial compound eye system. However, it i... |
41629319 | Protein nano-bioactives against microgravity-induced endothelial dysfunction. | Prolonged space missions expose astronauts to microgravity and cosmic radiation, leading to persistent vascular dysfunction driven by oxidative stress, cardiac deconditioning, and reduced physical activity. Current therapies are limited by adverse effects such as hypertension, hyperkalemia, and poor bioavailability, wi... |
41629306 | Delivery of peptide coacervates to form stable interaction hubs in cells. | Cells contain membrane-bound and membraneless organelles that operate as spatially distinct biochemical niches. However, these reaction centers lose fidelity due to aging or diseases. A grand challenge for biomedicine is restoring or augmenting cellular functionalities. An excited strategy is the delivery of protein-ba... |
41629308 | Electrochemical and photocatalytic generation of cis-olefin-bridged carbodication for umpolung [4+1] cycloaddition. | Carbodications, bearing two positive charges on carbon atoms, are emerging as powerful superelectrophiles in organic synthesis. Traditionally formed through single-electron oxidation of overcrowded electron-rich alkenes or acid-mediated dehydration of diols, these species show high reactivity toward carbon-based nucleo... |
41629213 | Boosting Electrocatalytic Ammonia Synthesis via Main-Group Metal Doping and Ionic Liquid Encapsulation in Copper Metal-Organic Frameworks. | The electrochemical nitrogen reduction reaction (EN<sub>2</sub>RR) provides a sustainable method for synthesizing ammonia at room temperature, but it is hindered by the low ammonia faradic efficiency (FE) and production yield. Herein, we report an effective EN<sub>2</sub>RR electrocatalyst: the ionic liquid-encapsulate... |
41629155 | Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease. | The papain-like protease (PL<sup>Pro</sup>) plays a key role in SARS-CoV-2 replication and represents a promising target for the development of new antiviral therapies. Previous efforts to develop fragment-derived inhibitors of PL<sup>Pro</sup> led to the identification of a novel class of spiro[chromane-2,4'-piperidin... |
41628594 | A Self-Catenated Metal-Organic Framework with Asymmetric Linkers and Its Adsorption of Furaltadone Antibiotic. | As a broad-spectrum antimicrobial agent, furaltadone is widely used in various sterilization fields. They are easily excreted into wastewater, resulting in bioaccumulation and posing risks to the local environment. In this work, a new metal-organic framework (MOF) with a previously unreported self-catenated net feature... |
41628566 | Atomistic Insights into Anomeric and Stereochemical Effects on Glucose Transport by GLUTs. | Although β-glucose is more abundant than α-glucose in aqueous solution, GLUT3 preferentially binds α-glucose due to favorable interactions and conformational complementarity within the protein binding site. This study explores the anomeric preferences of glucose transporters GLUT1 and GLUT3 for α- and β-glucose using c... |
41628488 | Self-Assembly of Linear Three-Ring Aromatic Thiols on Au(111). | We report on the self-assembly of linear three-ring aromatic thiols on Au(111)/mica substrates. Our study examines terphenylthiol (TPT) derivatives with distinct terminal groups -F (FTPT), -CF<sub>3</sub> (CF<sub>3</sub>TPT) and -NO<sub>2</sub> (NTPT) as well as a pyridinebiphenyl (PyBPT) compound. Using complementary ... |
41628316 | A Coordination Polymer Containing Pentagonal Bipyramidal Cd<sup>2+</sup> and Mixed-Organic Ligands: Exploration as a Differential-Luminescence-Responsive Probe and Catalyst for the Knoevenagel Condensation Reaction. | A new Cd-based coordination polymer (CP), [Cd<sub>2</sub>(L)<sub>2</sub>(PDA)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]·10H<sub>2</sub>O (where PDA = 1,4-phenylenediacetate and L = 2,4,5-tri-4-pyridyl-1H-imidazole), <b>1</b>, was successfully synthesized by utilizing the layer diffusion method. Comprehensive characteriz... |
41628325 | Proximity-driven acceleration of challenging solid-phase peptide couplings. | Many important solid-phase synthesis reactions proceed slowly and inefficiently, for example, the coupling of an activated ester to a sterically hindered, bead-displayed amine, a critical step in the synthesis of many peptides. Forcing conditions are often required to achieve acceptable yields. We show here that such r... |
41628279 | Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580. | Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the "block and lock" HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV transcriptional regulation. We previously identified ZL0580, a first-in-class BRD4-s... |
41628229 | Grik2b and Grik2c kainate receptors regulate oviposition in Bactrocera dorsalis. | Oviposition holds crucial significance for insect reproduction. Nevertheless, the research on the neural conduction mechanism of oviposition is still rather limited in most agricultural pests. Here, we demonstrate that the conserved Kainate receptors (KARs) expressed in the glutamatergic neurons (GNs) and the oviposito... |
41628183 | In-silico identification of anti-cholera phytochemicals from Indian medicinal plants. | Cholera is a severe diarrheal disease caused by ingestion of food or water contaminated with pathogenic Vibrio cholerae. Treatment for cholera includes rehydration therapy and antibiotics to avert death and reduce bacterial burden to prevent rapid transmission of the disease. In addition, in Indian subcontinent, there ... |
41628161 | Optimization, characterization and biological activity of siderophore produced by marine Streptomyces coelicolor. | Two Streptomyces spp. were isolated from open ocean waters of the Gulf of Mannar. Of the two isolates, one was identified as Streptomyces coelicolor through conventional and molecular approaches, and it was found to produce a siderophore. Characterization revealed the siderophore to be of trihydroxamate type with hexad... |
41628135 | Making cigarette taxes more effective in Mozambique: A simulation analysis using the Tobacco Excise Tax Simulation Model (TETSiM). | Cigarette price tax shares in Mozambique are among the lowest in Southern Africa. The excise tax share of the price of the most-sold brand is 14.7%, and the total tax share is 28.5%. The average excise tax share for the Southern African Development Community is 36.7% and the average total tax share is 51.6%. We used th... |
41627936 | Diels-Alder/Retro-Diels-Alder Reactions as Fold Altering Chemical Stimuli to Control the Self-Assembly of Aromatic Oligoamides. | Self-assembly of aromatic oligoamides into multihelical structures is a powerful strategy for developing complex and functional molecular architectures. As the hybridization process is directed by the folded state of the oligomers, inducing changes in the folding can be used to control the self-assembly. As one approac... |
41627832 | Research on tissue-resident macrophages in the field of cancer research: a bibliometric analysis from 2004 to 2025. | In the tumor microenvironment, tissue-resident macrophages (TRMs) promote malignant tumor progression, yet their tissue-specific heterogeneity and complex functions bring research challenges. This study analyzes the research status and trends of TRMs in oncology. Via VOSviewer, CiteSpace, R software and WoSCC, a visual... |
41627705 | Quantum charge transport in DNA and RNA systems coupled to nanoribbon electrodes. | The current-voltage behavior of three DNA nanowire models, which consist of a fishbone structure and two separate double-chain setups, alongside an RNA model illustrated by a half-ladder configuration, is examined using zigzag carbon nanotubes and associated metallic armchair graphene nanoribbon electrodes. This study ... |
41627680 | Nanomedicine in maternal viral infections: advancing prenatal therapies for fetal protection. | Viral infections during pregnancy can lead to several adverse outcomes, including miscarriage, stillbirth, intrauterine growth restriction, and neonatal complications, which may manifest congenital malformations and organ dysfunction. Infants who exhibit symptoms following maternal infection tend to have poorer health ... |
41627646 | Electrospinning of nanofibers and the functional potential of starch: a comprehensive review. | Electrospinning has emerged as a powerful nanofabrication technique for producing continuous polymer nanofibers with diameters ranging from sub-micrometers to nanometers. This technique is important in several discipline areas which are able to make high-surface-area materials with tunable properties that will allow ap... |
41627590 | Glutathione responsive nanomedicine leverages tumor redox imbalance for targeted cancer theranostics. | The glutathione (GSH) redox system plays a central role in maintaining cellular homeostasis, but its dysregulation in cancer contributes to tumor progression, therapy resistance, and metabolic adaptation. Elevated intracellular GSH levels represent both a barrier to conventional therapies and an opportunity to design r... |
41627522 | Tailoring of metal organic framework with electrospun polyacrylonitrile for on-chip electromembrane extraction and determination of anticancer drugs in biological samples. | An on-chip electromembrane extraction integrated with solid-phase microextraction (EME-SPME) was developed for the determination and monitoring of anticancer drugs, including imatinib, irinotecan, and mitomycin C, in various biological fluids. The extraction device incorporated an electrospun polyacrylonitrile (PAN)/MO... |
41627496 | Advancing nitrogen diagnostics in plants through bioimpedance spectroscopy: current evidence and future perspectives-a review. | Nitrogen (N) is an essential macronutrient that plays a central role in photosynthesis, metabolism, and crop productivity. Accurate and non-destructive evaluation of plant N status is essential for improving N use efficiency and sustainable fertilization. Bioimpedance spectroscopy (BIS) has emerged as a promising tool ... |
41627455 | Possible detrimental effects of postponed intubation during interhospital transfer of severely brain injured patients: retrospective analysis of the Traumaregister DGU<sup>®</sup>. | <h4>Purpose</h4>Prehospitally, the paradigm of obliged intubation in traumatic brain injured (TBI) patients with a reduced Glasgow Coma Scale (GCS) < 9 has been debated. Many patients with severe TBI need interhospital transfer to definitive care, so we sought to elucidate possible disadvantages for patients with a red... |
41627435 | Virulence arsenal of Acinetobacter baumannii: mechanisms driving persistence and resistance. | Acinetobacter baumannii is a Gram-negative opportunistic pathogen and a major cause of healthcare-associated infections, including ventilator-associated pneumonia, bacteraemia, meningitis, and urinary tract infections. Its persistence in hospital environments is due to its ability to survive desiccation, resist disinfe... |
41627426 | Natural variation in VrERF088 modulates drought tolerance during mungbean germination. | Drought stress is a major global challenge in crop production. The occurrence of drought during seed germination directly affects crop establishment and final yield. In this work, we performed whole-genome resequencing of 414 mungbean (Vigna radiata (L.) R. Wilczek) germplasms and identified 4,875,142 high-quality sing... |
41627285 | A Stable, Molecularly Imprinted Porous Hydrogel Membrane via Chemical Cross-Linking for Glyphosate Detection. | The stability of molecularly imprinted membranes (MIMs) is a critical factor influencing their reusability and detection performance. To overcome stability limitations, a robust porous imprinted hydrogel membrane (porous PVA/HS-β-CD/Ag/MIPs) was developed by grafting recognition sites onto a porous framework. The membr... |
41627250 | Sugar-Responsive Enzyme-Polyphenol 'Tooth Nanoarmor' for Long-Lasting Caries Prevention via Glucose Depletion and Biofilm Suppression. | High sugar intake in modern dietary patterns heightens the risk of dental caries, yet current preventives neither address dietary sugars nor effectively inhibit cariogenic biofilms. Herein, we introduce a fully biomass-derived enzyme-polyphenol 'tooth nanoarmor' that self-assembles from glucose oxidase (GOx) and ellagi... |
41627240 | Mastering Fluorescence through a Rare-Earth Ion Functional Switch in Isostructural Bimetallic MOFs. | The fluorescence properties of metal-organic frameworks (MOFs) are traditionally influenced by organic ligands, making the role of metal nodes, especially rare-earth centers in isostructural MOFs variants, a relatively understudied area. Herein, this study reports two isostructural bimetallic MOFs with identical organi... |
41627238 | How PNIPAM Microgel Architecture Controls Pickering Foam Formation. | The generation of foams using particle-like objects has gained momentum in the past years as such Pickering foams are relevant in many industrial applications. In this context, we investigate the foamability of microgels, which are soft polymeric particles which architecture can be finely tailored during synthesis. Her... |
41627058 | An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy. | Despite the availability of prophylactic vaccines, human papillomavirus (HPV) infection remains the leading viral cause of cancer worldwide. The HPV E7 oncoprotein is a key factor in cancer progression by degrading host tumor suppressor proteins, thus offering a promising target for antiviral therapy. In this study, we... |
41626813 | Ginsenoside Rb1 Targets the HRD1-STING Axis to Mitigate Cholesterol-Induced VSMC Senescence. | <h4>Background</h4>Vascular smooth muscle cells (VSMCs) are crucial components of the arterial wall, playing a vital role in maintaining vascular integrity and function. Previous studies have identified HRD1 as a potential target for alleviating senescence in VSMCs. Ginsenoside Rb1 has been shown to counteract endothel... |
41626683 | Highly Efficient and Selective Capture of Pb(II) through Lignin-Decorated Metal Organic Frameworks. | Metal-organic frameworks (MOFs) and their composites have demonstrated efficient and selective capture of heavy metal ions from aqueous solutions. In this study, a novel AL@Fe-BTC (lignin in situ growth of iron-based metal-organic framework Fe-BTC) was prepared by a one-pot method to grow Fe-BTC (metal-organic framewor... |
41626681 | Facile Synthesis of pH-Adaptive Ascorbate Peroxidase-like Nanozyme for One-Step Enzyme-Nanozyme Cascade Biosensing. | Nanozymes feature structural stability, functional diversity, and tunable activity, demonstrating promise in enzyme-nanozyme cascade systems for small molecule detection. However, the cascade performance is typically hindered by pH incompatibility and the cumbersome preparation of nanozymes. Herein, copper-doped zeolit... |
41623273 | Barriers to the application of Health Technology Assessment (HTA) results: the case of COVID-19 vaccine deployment in Ghana. | <h4>Objectives</h4>Health Technology Assessment (HTA) guides healthcare decision-making, while Implementation Research (IR) addresses challenges in operationalizing these decisions. The SAVING (Sustainable Access and Delivery of New Vaccines in Ghana) Consortium aims to enhance health intervention delivery in Ghana, fo... |
41623238 | Spectral Super-Resolution Colloidal SERS Spectroscopy for Multiplexed Detection of Protein Biomarkers. | Surface-enhanced Raman spectroscopy (SERS) possesses molecular specificity and single-molecule sensitivity. Yet, intensity-based SERS assays are vulnerable to nontarget analyte-induced intensity fluctuations, while frequency-shift-based SERS assays are constrained by the instrument's spectral resolution, limiting the t... |
41623249 | Characterization of the Sweet Taste Properties of Cyclodextrins and Their Derivatives and Their Underlying Molecular Mechanisms. | Cyclodextrins (CDs) are cyclic oligosaccharides with versatile functions and applications. However, knowledge about their taste properties and underlying molecular mechanisms is still quite limited. In this research, the sweet tastes of α-, β-, and γ-CDs were re-evaluated by a sensory test, and their efficacy to activa... |
41623197 | Ice-Templated Zwitterionic Sponge Hydrogels for Stable and Efficient Solar Desalination in High-Salinity Brines. | Solar-driven steam generation (SSG) offers a sustainable pathway for desalination, yet achieving temperature-regulated control over macroporous structures in salt-tolerant hydrogels remains a critical challenge. Here, we report a carbon black-coated PDMAPS sponge hydrogel (PDMAPS-CB-SH) fabricated via an ice-templated ... |
41623147 | Milling-Induced Defect Engineering of Zr-Based Metal-Organic Frameworks and Its Catalytic Applications. | Defect engineering of metal-organic frameworks (MOFs) has been shown to impact many properties of these porous structures, including affecting the accessible pore volume as well as introducing additional active sites to modify the catalytic activity of the frameworks. However, this defect engineering has previously pri... |
41622648 | Isoxazole-Stabilized Clathrate Hydrate for Hydrogen Storage. | Safe and efficient hydrogen (H<sub>2</sub>) storage remains a key challenge for a carbon-neutral energy future. Clathrate hydrates, ice-like lattices of hydrogen-bonded water, provide a sustainable platform for solid-state H<sub>2</sub> storage under moderate conditions; however, the molecular interactions governing th... |
41622389 | The emerging role of calsequestrin 2: from calcium sensor and modulator to arrhythmia driver. | Calsequestrin 2 (CASQ2) has emerged as a central sensor and modulator of calcium (Ca<sup>2+</sup>) dynamics in sarcoplasmic reticulum (SR), influencing both health and disease. This review explores the molecular architecture and multifunctional roles of CASQ2, beginning with its domain organization and Ca<sup>2+</sup>-... |
41622294 | Acoustic shape-morphing micromachines. | Shape-morphing mechanisms help organisms adapt to their environment and have inspired applications in advanced systems. Designing microrobots that are both miniaturized and capable of fast shape changes is challenging, as performance can be weakened at small scales. Ultrasound offers advantages such as fast response, r... |
41622249 | Facile Preparation of imidazole-functionalized nanofibers for Cobalt removal from spent lithium-ion batteries. | The escalating volume of spent lithium-ion batteries (LIBs) presents a critical challenge for environmental protection and resource sustainability, driving the need for efficient cobalt(II) recovery. To overcome the limitations of conventional adsorbents, such as complex synthesis and poor selectivity, this study devel... |
41405283 | Smartphone-assisted PEI@Eu-MOF lateral flow immunosensor for dual-modal POC detection of carbendazim. | Sensitive detection of carbendazim (CBZ), a widely monitored bactericidal pesticide globally, is critical to reduce risks to human health. In this study, Eu ions were embedded into a rigid metal-organic framework (MOF), to prepare Eu-MOF as a fluorescence signal source, which was subsequently post-modified with polyeth... |
40928308 | The Natural Product Osthole, Known for Its Insecticidal and Antimicrobial Properties, Potentially Binds to Amidase, Offering a Novel Approach for Controlling Tomato Gray Mold for the First Time. | Osthole exhibits strong inhibitory activity against phytopathogenic fungi; however, its antifungal mechanism remains unclear. This study assessed osthole's inhibitory effects on several phytopathogenic fungi, revealing a half-maximal effective concentration of 73.03 μg/ml against the hyphal growth of <i>Botrytis cinere... |
41909621 | A song of heads and tails: myosin II conformational regulation and filament dynamics shape force generation in non-muscle cells. | Non-muscle cells generate force without forming sarcomeres, building instead highly dynamic, contractile filaments that assemble, remodel, and disassemble in response to mechanical and biochemical signals. This review focuses on the conformational regulation and filament dynamics of myosin II paralogs as they define di... |
41847188 | Frontiers in bacterial outer membrane vesicles: From basic characteristics to cancer therapy. | Bacterial outer membrane vesicles (OMVs) are spherical nanostructures that originate from Gram-negative bacteria. They are gaining attention as powerful tools in cancer diagnostics and therapy due to their unique biological properties. These vesicles, which range from 50 to 250 nm in size, carry molecular components fr... |
41841492 | Structural and functional insights into the adenosine deaminase of the type III-B CRISPR-Cas system. | Type III CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins) systems confer antiviral immunity via cyclic oligoadenylate (cOA) signaling. Here, we elucidate a cooperative bacterial defense strategy involving two cOA-activated CRISPR-associated Rossmann fold (CARF)-conta... |
41837896 | Crown Ether Rotaxane-Induced Construction of COF Membranes With Recognition Channels for High-Efficiency Ion Sieving. | Biological ion channels can achieve high ion discrimination through the synergy between pore structure and microenvironment. However, constructing biomimetic ion-sieving membranes with precise recognition capabilities for target ions remains challenging. Herein, we propose a rotaxane-induced stacking method for constru... |
41815905 | Multifunctional lanthanide-based iron oxide luminescent-magnetic nanoparticles: synthesis, properties and biomedical applications. | Multifunctional nanocomposites that integrate lanthanide photophysics with iron oxide magnetism represent a rapidly expanding class of materials for precision bioimaging and theranostics. Lanthanide-based iron oxide nanoparticles (Ln-IONPs) uniquely combine the narrow f-f emissions, long-lived excited states, and UC/DC... |
41814818 | [Angelica sinensis polysaccharide-chitosan nanosystem synergizes with radiotherapy to enhance anti-tumor immunity and suppress tumor growth]. | To enhance the immunomodulatory effect of Angelica sinensis polysaccharide(ASP) on the tumor microenvironment, this study prepared ASP-chitosan nanoparticles(ASP-NPs) using a molecular self-assembly technique. The preparation process was optimized through single-factor investigation. The results from dynamic light scat... |
41809350 | Individual chemotherapy for patients colorectal cancer based on patient-derived tumor-like cell clusters. | <h4>Background</h4>Colorectal cancer (CRC) is among the most common malignant tumors. Chemotherapy remains central to CRC management, yet many patients still fail to derive optimal benefit. Patient-derived tumor-like cell clusters (PTCs), a preclinical three-dimensional tumor model containing primary epithelial cells, ... |
41805126 | Mitotic BLM functions are required to maintain genomic stability. | The BLM helicase is a critical genome maintenance protein involved in diverse cellular processes including DNA replication, repair, transcription, and chromosome segregation. During mitosis, it cooperates with the PICH helicase and topoisomerases to resolve ultrafine DNA bridges (UFBs)-nonchromatinized DNA structures t... |
41800924 | A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation. | Protein-based pharmaceuticals, such as engineered antibodies, form a major drug class of steadily increasing market share. However, these biologic medicines are costly to manufacture, are subject to strict supply chain and storage constraints, and often require invasive administration routes. Engineered microbes that s... |
41797815 | Recent advances and challenges in advanced oxidation processes for degradation of nano- and microplastics in water: a critical review. | This review consolidates recent advances in advanced oxidation processes (AOPs) for nanoplastic and microplastic (NMP) degradation, focusing on four major approaches: ozonation, photocatalysis, Fenton-based systems, and electrochemical oxidation. It critically examines how NMP characteristics, operational conditions, m... |
41789741 | Emergency cesarean section in pregnant women with severe pulmonary hypertension: the potential role of extracorporeal life support. | <h4>Background</h4>The aim of this study was to present our institutional experience with periprocedural management of emergency cesarean section (CS) operations and maternal and fetal cardiac complications in pregnant women with pulmonary hypertension (PH).<h4>Methods</h4>Thirteen patients who were diagnosed with PH d... |
41784268 | The molecular mechanisms of the ShosTA system in mediating anti-phage defense. | The ShosTA system, a two-component toxin-antitoxin (TA) system consisting of the ShosT and ShosA proteins, has recently been shown to mediate anti-phage defense. However, the molecular mechanisms underlying this system's role in anti-phage defense remain elusive. Here, we first confirmed that ShosT functions as the tox... |
41777852 | CPB@PLH NPs accelerate wound healing by antibacterial and anti-inflammatory effects. | Diabetic wounds are a severe complication of diabetes, with their non-healing nature closely associated with infection, oxidative stress, and the inflammatory microenvironment. To address the limited therapeutic efficacy of conventional antibiotics, which often lead to drug resistance and offer functionality, this stud... |
41777837 | Hybrid polythiophene-metal composites as promising sensing materials for chemical warfare agents and chlorofluorocarbons. | The effective detection of toxic industrial chemicals and chemical warfare agents (CWAs) demands sensing materials that combine high sensitivity with low production cost. Conducting polymers such as polythiophene (PTh) offer structural flexibility, yet their intrinsic electronic properties often limit sensing performan... |
41777816 | Composite A<sub>2</sub>M<sub>6</sub>O<sub>13</sub> anodes (A = Li, Na; M = Ti, Zr) for Li-Na dual cation batteries: a theoretical investigation. | The development of advanced anode materials is critical for improving the efficiency and durability of alkali-ion batteries. In this study, large-scale molecular dynamics simulations are employed to investigate the transport properties of A<sub>2</sub>M<sub>6</sub>O<sub>13</sub> (A = Li, Na; M = Ti, Zr) compounds in mo... |
41777821 | Rational design of click-assembled chiral dendrimers: anticancer activity and molecular dynamics study. | This study details the rational design, synthesis, and biological evaluation of a range of chiral dendritic compounds created using modular copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. We developed first-generation dendrimers (6-9) with systematically different degrees of chirality, comprisin... |
41777829 | Structural characterization and thermodynamic behavior of melittin-derived peptide interactions with gram-positive bacterial cell membranes using molecular dynamics simulation. | This study examined the interaction of different concentrations of a melittin-derived antibacterial peptide with Gram-positive bacterial membranes using molecular dynamics simulations. To achieve a more biologically representative model, the bacterial membrane composition was constructed using nine distinct phospholipi... |
41777838 | Porphyrin-based zinc metal-organic framework loaded with gallic acid as a novel nanoplatform exhibiting H<sub>2</sub>O<sub>2</sub>-activated reactive oxygen species generation and cytotoxicity in breast cancer cells. | A zinc-based metal-organic framework (MOF) engineered from tetrakis(4-carboxyphenyl) porphyrin (TCPP) as an organic linker and functionalized with gallic acid (GA) as an active therapeutic agent demonstrates remarkable potential for cancer treatment. The resulting Zn-TCPP@GA hybrid framework exhibits a high specific su... |
41777819 | Water-dispersible perovskite nanocrystals: synthesis strategies, ion sensing applications, and future prospects. | Perovskite nanocrystals (PeNCs) exhibit excellent optoelectronic properties including high quantum yield and tunable bandgap, making them promising for fluorescent sensing. However, their water sensitivity limits aqueous-phase applications. This review provides a critical analysis of strategies for preparing water-disp... |
41777817 | Bio-carbon quantum dot modified TiO<sub>2</sub> nanocrystals for photocatalytic degradation of PLA and PET microplastics. | Microplastic pollution is widespread, infiltrating water bodies and soil, entering the food chain, and thereby posing threats to ecosystems and human health. In this study, anatase titanium dioxide (TiO<sub>2</sub>) was prepared <i>via</i> a hydrothermal method and subsequently modified with bio-based carbon quantum do... |
41773021 | HPF1 regulates the formation of FUS-dependent compartments by PARP1 and PARP2 activation on damaged DNA. | FUS participates in the formation of biomolecular condensates associated with PARP1-dependent synthesis of poly(ADP-ribose) (PAR). HPF1 regulates auto- and hetero-PARylation activities of PARP1 and PARP2 and may influence the formation of FUS compartments during PARP1 or PARP2 auto-PARylation. In this study, we used at... |
41768452 | Design, Scalable Synthesis, and Characterization of Poly(Oligourethane Methacrylate)s Bottlebrushes with Discrete, Sequence-Defined, and Stereocontrolled Side-Chains. | Sequence and stereocontrol govern the sophisticated functionalities of biopolymers, such as proteins and nucleic acids. Unfortunately, although conventional polymerization methods are easy to perform, they often yield polymers with broad structural distributions, which limits the precise control over their physical pro... |
41761973 | Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury. | <h4>Background</h4>Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants. Neonatal hyperoxia induces a BPD-like phenotype and lung cell senescence in rodents. In our 3-day hyperoxia model, senescent cells were predominantly lung macrophages, with their abundance peaking at postnatal day 7 (pnd... |
41761969 | Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease. | Therapeutic strategies for ocular diseases are undergoing a transformative shift from symptom management to regenerative and disease-modifying approaches. This review highlights the development of neurotrophin receptor agonists-including recombinant nerve growth factor (NGF) (cenegermin), peptidomimetics (e.g., REC-055... |
41757826 | Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival Organoids. | <h4>Purpose</h4>We aimed to investigate the pathogenic role of sphingomyelin (SM) in dry eye disease (DED) and evaluate Ly93, an SM synthase inhibitor, as a potential therapy for DED-associated inflammation.<h4>Methods</h4>Tear samples from DED patients and healthy participants were analyzed for SM concentrations using... |
41755842 | Sticker-Spacer Molecular Design Controls Coacervate Formation and Internal Microenvironments in Low-Molecular-Weight Compounds. | Coacervates formed via liquid-liquid phase separation have been established as potential protocells in life studies. Unlike widely studied macromolecules, coacervates from low-molecular-weight (<i>M</i> <sub>w</sub>) compounds have recently gained importance because they provide simple but valuable in vitro models for ... |
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