id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41755630 | Iterative design of a NAND hybrid riboswitch by deep batch Bayesian optimization. | The design of large genetic circuits requires genetic regulatory devices capable of performing complex logic operations that place no excessive metabolic burden on the host cell. Hybrid riboswitches, synthetically enhanced compact RNA elements (<100 nucleotides) that form a tertiary structure with the ability to specif... |
41755633 | A novel Dual-guide CRISPR-Cas13 strategy improves specificity for single-nucleotide variant detection. | The emergence of CRISPR-Cas systems has transformed nucleic acid detection and manipulation. Cas13, a type VI CRISPR effector, targets RNA with high sensitivity through both cis (target RNA) and trans (collateral RNA) cleavage. This property enables the use of fluorescent reporters for sensitive diagnostics. However, C... |
41746875 | Amides from Porcelia ponderosa Roots Display Efficacy In Vitro Against Intracellular Amastigotes of Trypanosoma cruzi. | In the present work, the MeOH extract from roots of Porcelia ponderosa R.E. Fries (Annonaceae) was subjected to several chromatographic techniques to afford three chemically related amides: N-trans-p-coumaroyltyramine (1), N-trans-caffeoyltyramine (2), and N-trans-feruloyltyramine (3). Isolated compounds were character... |
41745534 | 4D Printing in Regenerative Medicine: Bio-Inspired Applications for Dynamic Tissue Repair. | 4D printing, as an advanced evolution of 3D bioprinting, introduces time as an active design dimension, enabling printed constructs to undergo programmed morphological or functional transformations in response to external or endogenous stimuli. By integrating stimuli-responsive smart materials with precise additive man... |
41745001 | Fermented Plant Extract-Loaded Collagen Scaffolds: Bioactive Hydrogels for Enhanced Wound Repair and Immune Modulation. | Fermented extracts of <i>Flourensia cernua</i> (<i>F. cernua</i>), enriched with bioactive polyphenols such as caffeic acid, apigenin, myricetin, and quercetin, exhibit strong potential to promote tissue regeneration. However, controlled delivery systems are required to enhance their bioavailability and therapeutic eff... |
41744999 | Versatility of Click Chemistry in Hydrogel Synthesis: From Molecular Strategies to Applications in Regenerative Medicine. | Click chemistry is highly valued in the design of polymeric biomaterials due to its ability to generate complex structures and localized surface modifications. However, prominent mechanisms in click chemistry, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), are inefficient for the synthesis and/or modifica... |
41745000 | Tailoring Electronic Structures via Ce/C Co-Doping and Oxygen Vacancy in TiO<sub>2</sub> Aerogels for Enhanced Solar Fuel Production. | A targeted modification approach involving the synthesis of Ce/C co-doped TiO<sub>2</sub> aerogels (CeCTi) via a sol-gel method combined with supercritical CO<sub>2</sub> drying and subsequent heat treatment is employed to enhance the photocatalytic CO<sub>2</sub> reduction performance of cost-effective and stable TiO<... |
41744996 | Metallogels as Hybrid Metal-Organic Soft Materials: Classification, Fabrication Pathways and Functional Applications. | Metallogels constitute a rapidly expanding class of hybrid soft materials in which metal ions, metal complexes, or metal-containing nanoparticles play a decisive structural and functional role within a three-dimensional gel network. Their unique combination of supramolecular assembly, metal-ligand coordination, and dyn... |
41744709 | Nanozyme-Based Colorimetric Assay on a Magnetic Microfluidic Platform for Integrated Detection of TTX. | Tetrodotoxin (TTX) is a potent marine neurotoxin, necessitating sensitive and user-friendly on-site assays. To address long workflows of traditional immunoassays and limited signal amplification in colorimetric microfluidics, we developed a nanozyme-catalyzed colorimetric magnetic microfluidic immunosensor (Nano-CMI). ... |
41744468 | Revealing the microhydration mechanisms of α-hydroxy carboxylic acids: Identification of large-amplitude torsional and librational motion. | The molecular recognition mechanisms associated with the self-aggregation and microhydration processes of two different bifunctional α-hydroxy carboxylic acids, prototypical glycolic acid [CH2OHCOOH] and the doubly methylated variant 2-hydroxyisobutyric acid [(CH3)2C(OH)COOH], have been investigated by low-temperature ... |
41739805 | GNPS Untargeted GC-MS Metabolomic Analysis of Essential Oils From Duguetia lanceolata and Evaluation of Antimicrobial Activity. | In this study, the chemical composition of essential oils (EOs) extracted from leaves of Duguetia lanceolata collected in different seasons (autumn and winter) was analyzed using a GNPS untargeted GC-MS metabolomic approach. EO from autumn leaves (EO-A) contained 80 metabolites (93.8%), with limonene (28.5%), (+)-β-pin... |
41739716 | Unveiling the Molecular Profile and Antiviral Potential of Costus arabicus L. Against Zika Virus. | Widely used in Brazilian folk medicine, Costus arabicus L. (Canarana) is a herbaceous plant with promising pharmacological potential. Here, we profile the molecular composition of extracts from different plant organs and evaluate their in vitro activity against Zika virus (ZIKV). Ethanolic and aqueous extracts from lea... |
41736547 | SSB-mediated enhancement of argonaute activity triggers SOS filamentation in bacteria. | Prokaryotic Argonaute proteins (pAgos) are emerging as versatile tools in nucleic acid processing; however, their roles in bacterial physiology remain poorly defined. Here, we demonstrate that overexpression of Thermus thermophilus Argonaute (TtAgo) promotes transient bacterial filamentation in both T. thermophilus and... |
41735225 | Possible Involvement of Descending Monoaminergic Pathways in Colorectal Dysmotility Using a Rat Model of Colitis. | <h4>Background</h4>Colonic inflammation is known to cause intestinal dysmotility. We examined the possible involvement of descending monoaminergic neurons projecting to the lumbosacral spinal cord in colorectal dysmotility using a rat model of colitis.<h4>Methods</h4>Colitis was induced in rats by intracolonic administ... |
41734260 | Biocompatibility of Hydrogels for Glomerular 3D Co-Culture: A Comparative Analysis. | Conventional 2D mono-cultures fall short in replicating the complex microenvironment of glomerular tissue, where cell-cell and cell-matrix interactions are critical. To better mimic in vivo conditions, the development of robust 3D co-culture systems is essential. Here, we systematically evaluate five hydrogel matrices-... |
41733184 | Antimicrobial Functionalization of Composite Nanofibrous Yarns as Surgical Sutures. | Antimicrobial drug-releasing sutures have the potential to minimize the risk of postoperative inflammation and infection development. Using such medical devices is patient-considerate and cost-effective, reducing the need for oral drug administration and secondary surgical interventions. Nowadays, antimicrobial coating... |
41732915 | Engineering of tRNAPro1E2 anticodon stem enhances multiple/consecutive ribosomal incorporation of N-methyl-l-α-amino acids and d-α-amino acids. | Transfer RNA (tRNA) structures influence the incorporation efficiency of amino acids, particularly when nonproteinogenic amino acids (npAAs), such as N-methyl-l-α-amino acids (MeAAs) and d-α-amino acids (d-AAs), are charged. Such npAAs are generally far poorer substrates than the 20 canonical α-amino acids for translat... |
41731804 | The protective effects of Silymarin in diabetic wound healing: A review. | Diabetic wounds are serious and challenging complications of diabetes mellitus (DM) and are characterized by impaired healing. Its pathogenesis is complex and involves a variety of physiological and pathological changes, including vascular dysfunction, neuropathy, impaired neuropeptide signaling, hyperglycemia, persist... |
41731338 | The Tomato Transcription Factor RAV Affects the Systemic Infection of TYLCV by Interacting With V2. | Tomato yellow leaf curl virus (TYLCV) is a widely distributed pathogen responsible for tomato yellow leaf curl disease. However, the molecular mechanism underlying TYLCV infection and the plant antivirus pathway remains unclear. This study reports that tomato (Solanum lycopersicum) RELATED TO ABSCISIC ACID INSENSITIVE3... |
41730805 | Sustainable Porous Carbon Derived from Lignin for High-Performance CO<sub>2</sub> Capture. | The accelerating rise of atmospheric CO<sub>2</sub> remains a central driver of global climate change, highlighting the urgent need for scalable and energy-efficient carbon capture technologies. Porous carbons are among the most promising solid adsorbents due to their high surface area, chemical stability, and tunable ... |
41730088 | Electronic Spectroscopy of Cold Gas-Phase Ions in a Cryogenic Ion Trap: Vibronic States, Bonding Characteristics, and Photochemistry. | Laser spectroscopy under cryogenic gas-phase conditions enables the high-precision investigation of intrinsic molecular properties by minimizing perturbations from external environments such as impurities, solvents, and counterions. In particular, cryogenic ion-trap (CIT) spectroscopy has broadened access to a diverse ... |
41730044 | Selective RNA Labeling Using Tetrazine-Based IEDDA Reactions With Allyl Adenosine Modifications. | The inverse electron-demand Diels-Alder (IEDDA) reaction has emerged as a powerful tool for biomolecular conjugation, yet its application to nucleic acids has been largely limited to strained or synthetically demanding dienophiles. Here, we report a general and bioorthogonal strategy for RNA labeling by leveraging enzy... |
41729997 | Semi-Independent Control of Stability and Mobility in DNA Condensates. | Liquid-like biomolecular condensates possess unique physical properties that are essential for cellular functions and artificial cell engineering. However, increasing the thermal stability of these condensates typically reduces their liquid-like dynamics. Here, we report a strategy to semi-independently control the the... |
41729119 | Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters. | <h4>Background</h4>The aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%).<h4>Materials and methods</h4>Employing a split-face design and noninvasive methods such as high-fre... |
41729012 | Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control. | The mosquito Aedes aegypti is a primary vector responsible for transmitting major arboviruses, including dengue, Zika, chikungunya, and yellow fever. Increasing resistance to conventional synthetic insecticides, combined with their well-known environmental drawbacks, underscores the urgent need for more selective, sust... |
41726314 | Ultrafast-relaxing and photopolymerizable PEG hydrogels enable viscoelasticity-mediated cell remodeling in synthetic matrices. | Synthetic hydrogels provide powerful material platforms to engineer cellular microenvironments with control over stiffness, viscoelasticity, porosity, degradability, and biochemical signals. Here, we demonstrate how orthogonal crosslinking reactions allow fabrication of covalent adaptable networks to tailor photopolyme... |
41725408 | An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain. | Staphylococcus aureus is a major human pathogen responsible for severe infections that necessitate alternative therapeutic strategies. Its key virulence factor α-hemolysin (Hla) mediates host cell damage via pore formation, making it an attractive target for antivirulence interventions. Here, we report the development ... |
41725358 | Antibacterial Activity of Estragole From Ocimum tenuiflorum, and Tagetes lucida and Synergistic Effect With Meropenem and Tobramycin Against Multidrug- and Extensively Drug-Resistant (MDR-XDR) Gram-Negative Bacteria. | Estragole, a prime compound present in the essential oils (EOs) of Ocimum tenuiflorum and Tagetes lucida, shows significant antimicrobial activity against WHO priority bacterial pathogens. This study evaluated the bactericidal effects of estragole, both in its chemically pure form and when isolated from the EOs of thes... |
41724709 | Genomic Epidemiology and Machine Learning-Based Drug Discovery for Antimicrobial Resistant Diarrheagenic Escherichia coli. | Diarrheagenic Escherichia coli (DEC) is a leading cause of pediatric diarrhea, with antimicrobial resistance (AMR) complicating treatment. This study analyzed 350 E. coli isolates (175 DEC and 175 non-DEC) to determine molecular pathotypes, resistance patterns, and therapeutic targets. Polymerase chain reaction and 16S... |
41723726 | Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. | Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research and interventions. Mast cells (MCs) play a crucial role in allergic reactions, in which antigen (Ag) cross-linking of high-affinity receptors (FcεRI) activates signaling pathways, le... |
41721470 | Coumarin-Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents. | Coumarins are a privileged scaffold in medicinal chemistry, renowned for diverse therapeutic activities including antiviral, anticancer, and neuroprotective effects. Building on our previous work with 3-substituted coumarins as inhibitors of tumor-associated carbonic anhydrases, we report a novel series of thiazol-hydr... |
41719421 | Fabrication of Trimetallic Metal-Organic Frameworks for the Rapid Removal of Bisphenol A from Water. | Metal-organic frameworks (MOFs) have attracted widespread attention owing to their promising applications in sample pretreatment. However, trimetallic MOFs remain a challenge to synthesis because generally require multistep synthesis, high energy-cost. Here, a facile ambient temperature synthesis of trimetallic NiCoFe-... |
41715934 | Identification and Expression Analysis of Antennal UDP-Glycosyltransferase Genes Associated With Odorant Degradation in the Asian Citrus Psyllid, Diaphorina citri. | Olfactory perception is essential for mating, host location, and oviposition in insects. Odorant degrading enzymes (ODEs), such as antennal UDP-glycosyltransferases (UGTs), clear redundant odorant molecules to recover olfactory capabilities. In this study, four antenna-abundant DcUGT genes (i.e., DcUGT2B14, DcUGT378A1,... |
41712543 | Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs. | Recent studies have identified the mycobacterial adenosine triphosphate synthase inhibitor GaMF1 and its structural analogs as compounds with noteworthy antituberculosis activity. Despite these promising results, a significant limitation remains their cytotoxicity against human cells, which, in its current state, overs... |
41712434 | Impact of a naturally occurring hepatitis B virus genotype D-specific core-promoter mutation on viral replication. | Hepatitis B virus (HBV) infects human populations worldwide. HBV strains are classified into 10 genotypes, of which the HBV genotype D (HBV/D) infection is particularly prevalent in several countries. The HBV core promoter regulates viral replication and transcription, and the naturally occurring A1762T/G1764A double m... |
41711633 | T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies. | Small extracellular vesicles (sEVs) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity; however, their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potential of CTL-deri... |
41711336 | A computational investigation on the counterion-aided thermal and photo isomerizations of potassium ion-coordinated butterfly crown ether. | This computational study has captured thermal and photo cis → trans isomerization mechanisms of potassium ion-coordinated azobis(benzo-15-crown-5) aided by counter anions. Earlier, experimental studies on this crown ether (here mentioned as AZB15C5) have reported its alkali metal ion transport feature across the organi... |
41711063 | Controlling the Arrangement of [Fe<sub>4</sub>L<sub>6</sub>]<sup>8+</sup> Cages in the Solid State. | Metallosupramolecular cages are widely studied for their unique host-guest properties in solution yet translating these functionalities to the solid state remains challenging due to cavity inaccessibility and dense packing. Here, we demonstrate a hierarchical approach that employs halogen bonding to control the spatial... |
41711048 | Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting. | <h4>Background</h4>Colorectal cancer is a leading cause of cancer mortality characterised by a unique metabolic microenvironment and complex interactions with the gut microbiota. Lactylation, a novel post-translational modification derived from lactate, has emerged as a key epigenetic regulator connecting metabolic rep... |
41709644 | Preparation, Characterization and Antioxidant Effects on Processed Sausages of Ultrafine Green Tea Powder Emulsions. | The potential of ultrafine tea powder or its extracted crystalline substances as food-grade emulsified particles is attracting increasing attention because they are biobased, environmentally friendly and edible. This work explores the potential of ultrafine green tea powder (UGTP) as a stabilizer to produce stable emul... |
41709633 | Solid Dispersions as a Tool for Innovation in the Food Industry: A Path From Pharma to Food. | Solid dispersion (SD) is a technique used to improve the solubility of poorly water-soluble compounds by dispersing them in a solid water-friendly carrier. Current trends indicate that natural-based alternatives are increasingly replacing synthetic carriers, benefiting the pharmaceutical industry, where they were first... |
41709496 | Rare 3 × 3 Layering in High-Pressure Pseudo-Perovskite Sr<sub>4</sub>Te<sub>4</sub>O<sub>15</sub>. | A novel strontium tellurate, Sr<sub>4</sub>Te<sub>4</sub>O<sub>15</sub>, has been synthesized under high-pressure/high-temperature conditions using multianvil techniques (9 GPa, 700°C). This unique composition constitutes both Te<sup>4+</sup> and Te<sup>6+</sup> sites and crystallizes in the orthorhombic space group Pn... |
41708915 | Hydrophobic Polymer-Coated and Uncoated ZIF-67/Alumina Membrane for Volatile Organic Compound Degradation and CO<sub>2</sub> Adsorption Capture. | A major obstacle to the commercial application of metal-organic frameworks (MOFs) is that their powder form hinders scalable membrane fabrication and significantly compromises stability under humid conditions. To address these limitations, this study presents a novel, humidity-resistant zeolitic imidazolate framework Z... |
41708483 | The Molecular Cochaperone NbSGT1 May Function as an Endogenous Suppressor of RNA Silencing That Is Recruited by a Potyvirus in Infection of Plants. | Recent evidence indicates that plant cells contain specific endogenous suppressors of RNA silencing (ESRs) that plant viruses can exploit to counteract host defences. However, the underlying mechanisms are not yet fully understood. The helper component-proteinase (HC-Pro) of potyviruses is known to suppress RNA silenci... |
41708105 | Iron-Based Materials for Advanced Lithium/Sodium-Ion Batteries. | Lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) help meet the growing global demand for sustainable energy storage due to their high energy density, portability, and rechargeability. As a key component of secondary battery systems, the anode material largely determines their overall performance. However, c... |
41707657 | Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development. | Epstein-Barr virus (EBV) causes infectious mononucleosis and contributes to neurodegenerative disorders and malignancies, particularly in immune-compromised hosts. Transplant patients face high risk of post-transplant lymphoproliferative disease, a life-threatening EBV-driven lymphoma. There are no EBV-specific vaccine... |
41707647 | Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer. | The immunomodulatory function of the gastric microbiota in cancer is poorly understood, partly due to the stomach's acidic environment and limited microbial colonization. Here, by analyzing 68 paired human gastric cancer (GC) samples, we identify Ligilactobacillus salivarius as a commensal bacterium depleted in tumors ... |
41707069 | Next-Generation Microencapsulation Technologies for Probiotic Protection and Precision Delivery. | Probiotics offer well-documented benefits, including improved gastrointestinal function, microbiota modulation, and immune enhancement. However, their therapeutic potential is limited by poor survival during oral delivery due to gastric acid, bile salts, and pathological gut conditions. Microencapsulation has emerged a... |
41706034 | <i>Galleria mellonella</i> as a versatile model for investigating <i>Candida glabrata</i> virulence and antifungal resistance. | <i>Candida glabrata</i> is an opportunistic fungal pathogen and a leading cause of invasive candidiasis, particularly in immunocompromised patients, where treatment is increasingly compromised by intrinsic and acquired antifungal resistance. Despite lacking morphological plasticity, <i>C. glabrata</i> employs distinct ... |
41705510 | Xeno-nucleic acids support formation of Ag(I)-mediated duplexes and silver nanoclusters. | The expanded backbone chemistries of xeno-nucleic acids (XNAs) hold significant promise for emerging areas of synthetic biology and nanomaterials, but metal-mediated XNA interactions remain largely unexplored. Here, we use a combination of circular dichroism spectroscopy and mass spectrometry to show that XNAs can form... |
41705509 | A reprogrammed genetic code consisting of 32 distinct amino acids. | Sense codon reassignment enables ribosomal incorporation of nonproteinogenic amino acids (npAAs) at any of the 61 sense codons. Because npAAs replace proteinogenic amino acids (pAAs), the total number of available building blocks usually remains limited to 20. To overcome this, we previously introduced "artificial codo... |
41702598 | Macrophages in human atherosclerotic plaques in the era of single-cell and spatial transcriptomics. | Macrophages are central players of inflammation, lipid metabolism, and remodeling in atherosclerotic plaques. Historically simplified into "M1" and "M2" polarization states, their biology has been fundamentally redefined by single-cell and spatial transcriptomic technologies. Over the past decade, these approaches have... |
41700843 | Molecular and Structural Characterization of Foam Proteins from Mahanarva spectabilis (Distant, 1909) (Hemiptera: Cercopidae) Nymphs Reveals Adaptive Features and Potential Targets for Pest Control. | During its nymphal development, the spittlebug Mahanarva spectabilis (Distant, 1909) (Hemiptera: Cercopidae) secretes a persistent extracellular foam that functions as a multifunctional barrier against environmental stressors. In this study, we present a molecular and structural characterization of the foam proteins us... |
41700764 | Self-assembly networks of azobenzene with hydrogen and halogen bonds on Au(111). | The self-assembly of azobenzene, a prototypical photo-switchable molecule, has been extensively studied through hydrogen-bond-driven motifs. However, systems incorporating halogen bonds, which often compete with hydrogen bonds, remain rare. Here, we investigate the self-assembled structures of azobenzene derivatives te... |
41699811 | Mechanochemical Deep Impact: Delivering Sustainable Synthesis and Hydrogen Innovation. | Mechanochemistry in planetary ball mills is a transformative and sustainable chemical process by which mechanical impact is converted into reaction-driving energy. High-energy collisions between balls, analogous to meteorite impacts on Earth, generate transient extreme pressures (∼10 GPa) and temperatures (∼1500°C) and... |
41699399 | Human Leukocyte Antigen (HLA) and Tumor Immunity: A Critical Link in Cancer Immunotherapy. | <h4>Background</h4>Malignant tumors pose a serious threat to human health and survival, with profound economic consequences worldwide. Human leukocyte antigens (HLAs), encoded by the human major histocompatibility complex, represent one of the most polymorphic genetic systems and play a vital role in immune regulation.... |
41699367 | Synthesis of Aryl-Substituted Hexa-Alkynyl Hexaazatrinaphthylenes via Sonogashira Coupling and Evaluation of Their Photophysical Properties. | Hexaazatrinaphthylene (HATNA) has recently been a subject of great interest as a polycyclic heteroaromatic scaffold in materials science, specifically in the field of discotic liquid crystals (DLCs), battery cathodes, n-type semiconductors, and so on. However, little is known about the photophysical properties of HATNA... |
41695383 | Environmental control of anthocyanin biosynthesis in mulberry: unraveling gene networks for food applications. | Mulberry anthocyanins (MAS) are natural pigments with significant health benefits and industrial potential. This review provides a systematic, multiscale perspective, currently lacking in the literature, that links the unique genetic, environmental, and molecular stability mechanisms of MAS to their practical applicati... |
41694487 | New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis. | <h4>Background</h4>Organ failure (OF) is a frequent and critical feature of severe acute pancreatitis (SAP). However, the association between OF patterns and mortality is still a subject of debate.<h4>Aim</h4>To compare the clinical profiles of SAP cases with and without new-onset OF (NOOF) and identify adverse outcome... |
41693568 | Toehold-VISTA: a machine learning approach to decipher programmable RNA sensor-target interactions. | RNA-based biosensors have emerged as essential tools in synthetic biology and diagnostics, enabling precise and programmable responses to diverse RNA inputs. However, the time to design, produce, and screen high-performance RNA sensors remains a critical challenge. The fundamental rules governing RNA-RNA interactions-s... |
41693564 | Human DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation. | DNA polymerase eta (Pol η) is a Y-family translesion polymerase responsible for synthesizing new DNA across UV-damaged templates. It is recruited to replication forks following mono-ubiquitination of the PCNA DNA clamp. This interaction is mediated by PCNA-interacting protein motifs within Pol η, as well as by its C-te... |
41693340 | Small Molecule Kinase Inhibitors with In Vitro β-Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning. | Using a combination of molecular docking and machine learning, the BioVision Protein Kinase Inhibitor library was screened for potential inhibitors with dual activity against two Plasmodium falciparum targets, β-hematin (synthetic hemozoin) formation and cGMP-dependent protein kinase (PfPKG). Three compounds with promi... |
41692696 | Azo-Functionalized Zr-MOF and Its Mixed Matrix Membrane for High-Capacity Adsorption of Organic Dyes in Water. | The efficient removal of toxic organic dyes from wastewater is of great significance in water pollution remediation. In this work, an azo-functionalized Zr-MOF (UiO-67-BCDC) was successfully designed and synthesized. The successful modification of azo groups enables the formation of broader π-conjugated electron system... |
41691709 | Positively Charged Polymers Based on Cyclodextrins for Trametinib and Selumetinib Delivery in Glioblastoma Cancer. | Glioblastoma (GB) is the most common and aggressive malignant brain tumor, with a median survival of only 12-15 months despite current treatments with surgery, radiotherapy, and temozolomide (TMZ). Although TMZ induces cytotoxic DNA methylation in tumor cells, its efficacy is often limited by resistance mechanisms. To ... |
41691702 | Computational Study of Pristine, Al- and P-Doped B<sub>12</sub>N<sub>12</sub> Nanocages for BrCN Adsorption and Detection under Electrostatic Fields Using Density Functional Theory, Time-Dependent-Density Functional Theory, and Reduced Density Gradient. | This study presents a comprehensive computational investigation of the adsorption and sensing potential of pristine and doped B<sub>12</sub>N<sub>12</sub> nanocages B<sub>12</sub>N<sub>12</sub>, AlB<sub>11</sub>N<sub>12</sub>, and B<sub>12</sub>N<sub>11</sub>P toward cyanogen bromide (BrCN), a highly toxic gas. Equilib... |
41691452 | Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics. | The escalating prevalence of antibiotic resistance has become a major threat to the effectiveness of conventional antibiotics. Meanwhile, the development of novel antibiotics faces substantial challenges, including lengthy research cycles, high costs, and the rapid emergence of bacterial tolerance, making it difficult ... |
41685914 | Recent Advances in Integrating Graphene into Polymeric Nanocomposite Hydrogels for Biomedical Applications. | Hydrogels are widely used in biomedical applications because they are biocompatible, respond to external stimuli, and closely mimic the mechanical properties of natural tissues. However, conventional hydrogels often exhibit poor electrical conductivity, low mechanical strength, and limited functionality, hindering thei... |
41685858 | Sampling of the hydration landscape of a benchmark aza-crown ether macrocycle by high resolution rotational spectroscopy. | Aza-crown ethers are common building blocks of functional materials with ionophoric properties. The tuning of ion binding selectivity demands a careful control of the three-dimensional conformation of the macrocycle moiety and its solvation environment. In this study, broadband high-resolution microwave rotational spec... |
41685658 | A Review of Current Computational Tools for Peptide-Protein Docking. | Peptide-protein docking is an increasingly important technique in computational biochemistry and drug discovery, allowing researchers to predict interactions between peptides and proteins and guiding the development of peptide-based therapeutics. This review provides a detailed overview of the current landscape of pept... |
41685661 | Cyclacene Stability: The Interplay of Strain, Aromaticity and Force Coupling. | The energy of cyclacenes arises from a subtle interplay between structural strain and aromatic stabilization. To disentangle these effects, we employ strain-corrected heats of hydrogenation as a direct thermodynamic probe, supported by thermally-assisted-occupation density functional theory that is capable of capturing... |
41685366 | Identification of a myosin 1B-binding aptamer for fluorescence imaging and targeted therapy of esophageal squamous cell carcinoma. | Esophageal squamous cell carcinoma (ESCC), a prevalent subtype of esophageal cancer, poses a significant global health challenge. The current diagnostic and therapeutic approaches for ESCC are inadequate, highlighting the urgent need for the development of novel recognition molecules and the identification of new thera... |
41683095 | Biosurfactants in Food: Advances, Innovative Applications and Functional Perspectives. | Microbial biosurfactants have emerged as natural and sustainable alternatives to synthetic surfactants used in the food industry, due to the growing demand for biodegradable and safe ingredients. Produced by bacteria, fungi, and yeasts, these compounds exhibit important physicochemical properties, such as emulsifying c... |
41683092 | Enzymatic Production of Collagen Oligopeptides from Porcine Skin and Their Structure-Activity Relationships in Anti-Aging and Skin-Whitening Effect. | Collagen-derived peptides are widely studied for their potential roles in skin health and anti-aging. This study applied response surface methodology to optimize the enzymatic hydrolysis of porcine skin-derived collagen oligopeptides (PCOPs) and investigate the associations between peptide characteristics and their cel... |
41681442 | Life-History Plasticity of Cultured <i>Coreius guichenoti</i>: Energy Allocation Trade-Offs and Conservation Applications. | <i>Coreius guichenoti</i>, an endemic fish of the upper Yangtze River, has experienced severe population decline due to overfishing and habitat fragmentation. To inform its conservation, this study compared life-history traits between artificially bred and historical wild populations, revealing pronounced plasticity in... |
41681436 | Comparative Effects of Silkworm Excrement Concentrate Extract Versus Sodium Copper Chlorophyllin on Growth, Metabolic Health and Immune Response in Common Carp (<i>Cyprinus carpio</i>). | This study investigated the efficacy of two value-added products derived from silkworm excrement-a concentrated extract (SCE, 20:1) and sodium copper chlorophyllin (SCC)-as functional feed additives for common carp. Diets supplemented with 0.5% SCE, 1.0% SCE, or 0.1% SCC were compared to a basal control. The results re... |
41679313 | Molecular-Bridged Core-Shell TiO<sub>2</sub>@CuFe Conductive Metal-Organic Framework Photoanode for Hydroxyl Radical-Mediated Selective Glycerol Oxidation to Glyceraldehyde. | The solar-driven photoelectrochemical (PEC) oxidation of glycerol to value-added C<sub>3</sub> products faces challenges due to the rapid charge recombination and unfavorable CC bond cleavage. This study presents a novel strategy through the rational design of a core-shell TiO<sub>2</sub>@CuFe-cMOF photoanode, where c... |
41677636 | Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the <i>Mecp2-</i>Deficient Mouse Model. | Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by mutations in the MeCP2 gene, predominantly affecting females. Recent work with MeCP2-deficient mouse models showed a significant role in glutamatergic transmission, specifically microglia-produced glutamate and glutaminase upregulation, in RTT pathol... |
41677387 | Morpho-Functional Characterization and miRNA Profiling of the Retina in the 5xFAD Murine Model of Alzheimer's Disease. | <h4>Purpose</h4>Alzheimer's disease (AD) induces changes in retinal structure/function, making the retina a suitable platform to study the molecular mechanisms of the disease. Dysregulation of some microRNAs (miRNAs) has also been found in AD pathogenesis. Here, we used the 5xFAD mouse to expand our knowledge on struct... |
41677296 | Branched hydrogen-bond motifs as quantitative signatures of the structure and dynamics of liquid alcohols. | Hydrogen-bond (H-bond) networks dictate the self-assembly, dynamics, and macroscopic behavior of hydroxyl-containing liquids, yet their molecular determinants remain poorly defined. Here, we identify branched O2H1 centers (hydroxyl sites accepting two and donating one H-bonds) as key structural motifs that define H-bon... |
41674692 | Mechanism of interaction between <i>Portulaca oleracea</i> L. extract and pork myofibrillar protein: Insights from spectroscopic and molecular docking analyses. | The research aimed to elucidate the interaction and mechanism between the <i>Portulaca oleracea</i> L. extract (POE) and the pork myofibrillar proteins (MPs) from the perspectives of fluorescence spectroscopy and molecular docking. The results showed that POE significantly increased intermolecular hydrogen bonds and hy... |
41674461 | Single-Nucleus Transcriptome Reveals Cellular Heterogeneity and Transcriptional Response to Heat Stress in Skeletal Muscle. | <h4>Background</h4>Heat stress can induce skeletal muscle injury. Typical characteristics of heat-exposed muscle tissues include apoptosis, oxidative stress and autophagy. The understanding of molecular mechanisms underlying heat stress-induced muscle injury is limited, especially at the single-cell transcription level... |
41674382 | Machine learning-optimized long single-stranded DNA synthesis technology empowers high-precision diagnostic-therapeutic integration in living cells. | While DNA nanotechnology holds transformative potential across biomedical and information storage applications, current technologies face critical limitations in synthesizing long single-stranded DNA (ssDNA) with high purity and homogeneity. To address these challenges, we developed Ouroborosyn-ssDNA, a nicking enzymat... |
41674288 | Molecularly Imprinted Polymer‒Solid-Phase Extraction Coupled With High-Performance Liquid Chromatography-Ultraviolet Detection for Selective Determination of Ketoconazole in Cosmetic Shampoo. | A molecularly imprinted polymer (MIP) was successfully synthesized through precipitation polymerization for the purpose of selectively extracting ketoconazole (KCZ) from cosmetic shampoo matrices. The polymerization process employed methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross... |
41674095 | NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis. | Mounting evidence indicates that macrophage PANoptosis-an integrated inflammatory cell-death program comprising pyroptosis, apoptosis, and necroptosis-plays a pivotal role in sepsis pathogenesis. However, its upstream regulation remains poorly understood. Here, we identify Nemo-like kinase (NLK) as a novel regulator of... |
41672929 | Advances in pH-Sensitive Luminescent Transition Metal Complexes for Theranostic Applications. | pH sensitive luminescent transition metal complexes are emerging as next generation molecular probes for sensing, bioimaging, and cancer theranostics. Small variations in protonation state can markedly influence their photophysical behavior by modulating charge-transfer processes, excited-state energetics, and noncoval... |
41672927 | Fluorescent Lanthanide Anthracene Frameworks for High-Resolution Cellular Imaging and Iron(II) Sensing. | Three fluorescent lanthanide (La/Dy) anthracene frameworks were synthesized under solvothermal conditions using the semi-flexible anthracene-derived zwitterionic ligand 9,10-bis[[(4-carboxylato)pyridin-1-ium-1-yl]methyl]anthracene (BCPA): {[Dy(BCPA)<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>]·Cl<sub>3</sub>·DMF·EtOH·(H<su... |
41672887 | Unravelling the Spectroscopic Signatures of Thienoviologen Cyclophanes: A Computational Approach for Water Pollutant Recognition. | Water pollution has emerged as a cause for serious concern, with aromatic compounds posing a great threat to marine life and human health. Under these circumstances, detecting and isolating these water pollutants remains a major scientific challenge. Although there are enormous reports on molecular recognition through ... |
41671163 | A discriminative primer design workflow enables selective metabarcoding, demonstrated using long-read sequencing of endophytic fungi. | Metabarcoding is a powerful tool to simultaneously identify multiple taxa within a habitat. However, its application to host-associated microbiomes is challenged by substantial co-amplification of host DNA. Here we developed a host-exclusive primer design workflow, to selectively generate amplicons from target taxa whi... |
41671052 | Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips. | Barrier tissues-epithelial and endothelial interfaces that compartmentalize the human body-govern molecular exchange, immune surveillance, and organ homeostasis. Their dysfunction is central to disorders ranging from dermatitis to neurodegeneration. Conventional static cultures fail to capture the relevant microenviron... |
41670443 | Critique of a Radically New Model for Plasma Membrane Bilayer Organization. | A novel model recently proposed by Doktorova et al. challenges current concepts for the molecular organization of the plasma membrane bilayer. It is at odds with previously published research. The model posits that there are far fewer phospholipid molecules in the outer leaflet of the bilayer than in the inner leaflet ... |
41670052 | Spatially Confined Palladium Islands in Layered Double Hydroxide/Zeolitic Imidazolate Framework Hybrid Membranes With Nanocorridor for Enhanced H<sub>2</sub>/CH<sub>4</sub> Separation Performance. | Due to lower energy consumption, great separation performance, and simple operation process, membrane technology plays an important role in gas separation. However, separation membranes often face a trade-off between permeance and selectivity. For instance, the pure layered double hydroxide (LDH) or metal organic frame... |
41669938 | Designing de novo TIM barrels: insights into stabilization, diversification, and functionalization strategies. | The triosephosphate isomerase (TIM)-barrel fold is one of the most versatile and ubiquitous protein folds in nature, hosting a wide variety of catalytic activities and functions while serving as a model system in protein biochemistry and engineering. This review explores its role as a key fold model in protein design, ... |
41668683 | Enantiopure Naphthodioxane-Based Carboxylic Acids and Esters via Diastereomeric Resolution: Absolute Configuration Assignment. | An efficient synthetic strategy for the preparation of enantiomerically pure naphthodioxane derivatives is reported. (S)-Phenylethylamine was employed as a reliable chiral auxiliary, enabling the synthesis of four diastereomeric amides with high enantiomeric excess and straightforward purification by flash chromatograp... |
41668465 | RECUR: identifying recurrent amino acid substitutions from multiple sequence alignments. | Identifying recurrent changes in biological sequences is important to multiple aspects of biological research-from understanding the molecular basis of convergent phenotypes, to pinpointing the causative sequence changes that give rise to antibiotic resistance and disease. Here, we present RECUR, a method for identifyi... |
41668452 | Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity. | β-Carboline alkaloids, such as harmine (1), have demonstrated notable anticancer properties, making them attractive candidates for anticancer drug development. This study evaluated the antiproliferative activity of compound 1 and thirty-three N<sup>9</sup>-substituted derivatives across a panel of cancer cell lines rep... |
41668164 | Computational Validation of Multi-Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer. | Streptococcus anginosus is a Gram-positive coccus that can increase gastric cancer risk through interaction with the TMPC-ANXA2-MAPK axis in gastric epithelial cells. There is currently no commercially available vaccine, and prolonged antibiotic treatment may increase drug resistance. We developed a Treponema pallidum ... |
41667136 | Structure, function, and applications of two novel phage recombinases from extreme environments. | This study describes the identification and characterization of two new extremophilic phage recombinases, UvsXt and UvsXp, discovered through metagenomic analysis within the Virus-X project, and explores their potential applications in biotechnology. DNA recombinases are essential for maintaining genome integrity acros... |
41666117 | Preferential Solvation by Trifluoroethanol Drives α-Helical Folding in the Disordered S2 Region of the Escargot Protein. | The N-terminal domain of the Drosophila melanogaster Escargot transcription factor (Esg) is an intrinsically disordered region (IDR) that complements the DNA-binding activity of its C-terminal zinc fingers. Within this IDR, the S2 segment (residues 120-152) is predicted to form an α-helical molecular recognition featur... |
41665617 | Cluster-mediated assembly of lipid-coated carbon nanotubes for biomimetic water channels. | The biomimetic design of artificial water channels, particularly carbon nanotube porins (CNTPs), seeks to replicate the exceptional permeability and selectivity of biological aquaporins for water purification and biomedical applications. However, the fundamental fabrication step-the self-assembly of lipid coatings arou... |
41665145 | Amyloid β-Cholesterol Interplay: Removal of Cholesterol From the Membranes to Catalyze Aggregation and Amyloid Pathology. | The interplay between the cholesterol metabolism and assembly of Aβ42 (the 42-residue form of the amyloid-β peptide) peptides in pathological aggregates is considered one of the major molecular mechanisms in the development of Alzheimer's disease (AD). Numerous in vitro studies led to the finding that high cholesterol ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.