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41665012 | Scaffolding of the H4K5ac chromatin remodeling complex by lncRNA MAHAC mediates epithelial-mesenchymal transition. | Anchoring of a chromatin remodeler complex by long non-coding RNAs (lncRNAs) is a frequently utilized mechanism for lncRNAs to regulate gene expression. Hypoxia is a microenvironmental condition that plays a crucial role in promoting tumor progression. We previously identified a hypoxia-inducible lncRNA, RP11-390F4.3, ... |
41665008 | Structural basis of Retron-Eco8-mediated antiphage defense. | Retrons represent a novel class of bacterial defense systems that employ reverse transcriptase (RT), noncoding RNA, and effector proteins to counteract phage infections. In this study, we elucidate the molecular mechanism of a retron system, Retron-Eco8. Biochemical experiments reveal that the Retron-Eco8 holocomplex, ... |
41661040 | A template-based automatic fragmentation algorithm for complex and large systems in the generalized energy-based fragmentation framework. | A major bottleneck in low-scaling energy-based fragmentation methods is the need for manual intervention in the fragmentation step, which is time-consuming, inconsistent, and hard to generalize across diverse molecular systems. To address this challenge, we develop a template-based automatic fragmentation algorithm tha... |
41657175 | [Effect of Organic Fertilizers on the Accumulation and Distribution of Polystyrene Nanoplastics in Cotton Plants]. | In order to investigate whether the addition of organic fertilizers could reduce the uptake and accumulation of polystyrene nanoplastics （PS-NPs） in the roots and stalks of cotton plants， a pot experiment was conducted using different amounts of organic fertilizers （0 g·kg<sup>-1</sup> and 10 g·kg<sup>-1</sup>） combine... |
41656765 | MdWRKY75 interacts with MdWOX11 to modulate root growth under salt stress in apple. | The root system is pivotal for plant development, enabling both vegetative growth and tolerance to abiotic stresses like salinity. However, the molecular mechanisms governing root adaptive development in response to salt stress remain poorly understood in apple (Malus domestica Borkh.). In this study, we identified the... |
41656550 | The Effect of Silk Fibroin Additive on the Properties of Tannic Acid-Based Bioadhesives. | Hydrogel adhesives have attracted significant attention for diverse biomedical applications, including tissue engineering, wound dressings, crack propagation prevention, and hemorrhage control. In this study, a tissue adhesive composed of polyethylene glycol, tannic acid, and gelatin, with different concentrations of s... |
41655265 | Preparation and Evaluation of the Synergistic Benefits of a Glycoside-Pyrone-Based Multifunctional System as a Possible Regulator for Melanogenesis. | The skin is constantly exposed to external factors throughout a person's life, ultraviolet (UV) radiation being one of the most harmful. The primary defence against UV-induced damage is skin pigmentation, which is achieved through the synthesis of melanin. However, overproduction of melanin can lead to skin disorders s... |
41655129 | Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts. | Senescent fibroblasts accumulate in the connective tissue of all organs and promote organ aging and aging-related diseases. The underlying mechanisms for the accumulation of senescent fibroblasts are poorly understood. Natural killer (NK) cells of innate immunity play a critical role in the removal of tissue resident s... |
41655072 | Rational Design of Functional Metal-Organic Frameworks as Chromatographic Stationary Phases: From Synthesis to Advanced Applications. | Metal-organic frameworks (MOFs) have emerged as highly promising stationary phases in chromatographic separation technologies due to their exceptional structural tunability, high surface areas, and tailored pore environments. However, the transformation of these intrinsic advantages into practical chromatographic perfo... |
41655070 | Microscale Affinity Chromatography for Biointeraction Analysis: Strategies, Principles and Applications. | The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies. This approach makes use of... |
41653824 | Self-assembled nanostructures of 3ph-imi[FeCl<sub>4</sub>] as a strong ice recrystallization inhibitor. | Ice recrystallization inhibition (IRI) materials are important in both fundamental research and practical applications, but achieving efficient regulation through molecular design remains challenging. Herein, we synthesized a series of imidazole-based ionic liquids with triphenyl groups, 3ph-imi[X], and investigated th... |
41653367 | Olympic Snow Sports: Current Insights and Future Directions for Milano Cortina 2026 and Beyond. | As the Milano Cortina 2026 Winter Olympic Games approach, a comprehensive understanding of performance determinants across Olympic snow sports is increasingly important to further evolve training and performance. However, the scientific literature remains unevenly distributed, with well-established knowledge in cross-c... |
41643180 | Design, Synthesis, Biological Evaluation, and In Silico Analysis of Novel Antifungal Agents Targeting Trichophyton Species. | Terbinafine (Tb) is the primary commercial treatment for superficial nail infections; however, resistance is an emerging public health concern, largely driven by point mutations in the squalene epoxidase (SQLE) gene that reduce the drug's effectiveness. In this work, five novel synthetic compounds were developed and ev... |
41641846 | A comparative pharmacokinetic evaluation of two aqueous progesterone 25 mg injections in healthy postmenopausal women under fasting conditions: An open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover bioequivalence study. | The growing demand for assisted reproductive technology (ART) has increased the need for effective luteal phase support. Progesterone, essential for maintaining early pregnancy, is a critical component of ART. This open-label, balanced, randomized, two-treatment, crossover, single-dose study compared the bioequivalence... |
41641775 | A Coumarin Compound Derived From Zanthoxylum avicennae Reduces the Pathogenicity of Fusarium verticillioides by Directly Binding to and Inhibiting Glycoside Hydrolase 3 Activity. | The cell wall serves as a critical barrier in plant defence against pathogen infection, whereas various Fusarium fungi secrete cell wall-degrading enzymes (CWDEs) to facilitate hyphal infection. In this study, luvangetin, a coumarin compound isolated and identified from the root of Zanthoxylum avicennae, was found to a... |
41641527 | [Design of ZIF-L-based boronate affinity molecularly imprinted material and its application in the detection of ribavirin in environmental water]. | Ribavirin （RBV） is a broad-spectrum antiviral drug. It is widely used to treat various viral infections. However， its entry into water bodies can cause serious harm to both the ecological environment and human health. Thus， there is an urgent need for a simple and efficient method to detect RBV for detection purposes. ... |
41641526 | [Tripeptide polymer-based cell-imprinted hydrogels for high-efficiency circulating tumor cell capture]. | Circulating tumor cells （CTC） have emerged as crucial mediators in the metastatic cascade， offering invaluable insights as real-time liquid biomarkers for cancer progression， prognosis， and treatment response. Their exceptionally low concentration in peripheral blood， which typically ranges from a handful to a few doze... |
41641521 | [Design and synthesis of molecularly imprinted polymers and their applications in medical diagnosis and biocatalysis]. | Molecularly imprinted technology （MIT） represents an advanced synthetic strategy that emulates biological recognition mechanisms， such as antigen-antibody or enzyme-substrate interactions， by creating three-dimensional cavity-like structures through the directional assembly of functional monomers around a template mole... |
41641523 | [Research progress on the application of molecularly imprinted nanozymes in the field of biosensing]. | Enzymes， as biological catalysts， have garnered significant interest due to their exceptional efficiency and specificity. However， the fragility of natural enzymes under varying temperature and pH conditions significantly restricts their broader utilization. In the past few years， noteworthy advancements have been achi... |
41641525 | [Preparation of superhydrophilic imprinted resin-graphene aerogel composite and its precise recognition of tumor biomarker in urine]. | In recent years， molecularly imprinted polymers have shown considerable promise in analytical detection and early diagnosis of diseases due to their high selectivity and specificity. Nevertheless， the practical implementation of these methods is still restricted by several intrinsic limitations associated with traditio... |
41641524 | [Application of molecularly imprinted polymers-based sensors for determination of acute coronary syndrome biomarkers]. | Cardiovascular diseases （CVDs） are among the leading cause of global morbidity and mortality. Due to their high prevalence and often asymptomatic progression， there is a pressing need for diagnostic tools that enable the early， accurate， and accessible detection of them. Acute coronary syndrome （ACS）， as a common and s... |
41641522 | [Applications of molecularly imprinted solid-phase microextraction coupled with chromatography/mass spectrometry for determination of drug residues]. | Drugs play an indispensable role in the fields of medicine， agriculture， and animal husbandry. However， their long-term and improper use may lead to drug residues in food， the environment and organisms， posing a potentially serious threat to human health and the ecological environment. For instance， antibiotic residues... |
41641520 | [Molecularly imprinted polymers： novel green preparation methods and cutting-edge applications review]. | Molecular imprinting technology is an emerging technique that achieves specific recognition of imprinted molecules by simulating the interactions between antibody and antigen or between enzyme and substrate. The core of this technology lies in the preparation of molecularly imprinted polymers （MIPs）. However， tradition... |
41638080 | Dual kinetics-enhanced crystalline BiOF hollow nanorods toward high-capacity and high-rate aqueous alkaline batteries. | Lack of double-high (high energy density and power density) anode materials is the key bottleneck for the application of Aqueous alkaline batteries (AABs). Although the emergence of Bismuth-based materials provides an opportunity to solve this issue, due to their high theoretical capacity via a three-electron redox rea... |
41637919 | Repurposing sulfonamide drugs as anticancer ligands and understanding its properties through density functional theory. | Drug repurposing represents a promising approach towards drug discovery that has the potential to improve patient outcomes and address unmet medical needs. This study attempted to repurpose existing sulfonamide drugs in search of novel anticancer drugs because of their effectiveness in treating bacterial infections. A ... |
41637118 | In Silico Study of the π-π Stacking Interactions in Borazine-Borazine, Boroxine-Boroxine, Borazine-Boroxine Complexes and Their Substituted Derivatives. | The study investigates the stacking interactions between borazine-borazine, boroxine-boroxine, and borazine-boroxine complexes and their substituted derivatives, obtained by replacing all the hydrogen atoms with the electron-withdrawing -F and the electron-donating -CH<sub>3</sub> groups. The strength of these interact... |
41637116 | Efficient Detection of Esomeprazole Magnesium Using Self-Assembled Supramolecular of Chiral Dicyanovinylene End-Capped H<sub>8</sub>-BINOL With AIE Properties. | Various benzene and heterocyclic structures could be connected to both 3,3'-positions of H<sub>8</sub>-BINOL by Suzuki coupling reactions. The dihedral Angle of H<sub>8</sub>-BINOL was reduced by the electron-withdrawing groups on the benzene ring, and the dihedral angle was smaller with stronger electron-absorbing abi... |
41636451 | Association and phase transitions in simple models for biological and soft matter condensates. | We investigate a set of design principles that link specific features of interparticle interactions to predictable structural and dynamic outcomes in two-dimensional self-assembly, a framework relevant to soft matter and biological condensates. Using extensive molecular dynamics simulations of single- and two-component... |
41636280 | Ion-Tolerant, Injectable, and Biocompatible Pyrene-Amino Acid Supramolecular Hydrogels for Antimicrobial Applications in Saline Media. | Herein, we report an ion-tolerant supramolecular hydrogel formed from a pyrene-conjugated amino acid in an electrolytic (saline) aqueous medium with a minimum gelator concentration of 1.8 mM. The hydrogel exhibits thermoreversible and thixotropic behavior, undergoing reversible gel-sol transitions in response to therma... |
41635965 | Capillary Electrophoretic Chiral Separation of Antihistamines: Enantiomers Recognition Mechanism by Isothermal Titration Calorimetry and Simulation Studies. | The chiral separation of chlorpheniramine, brompheniramine, and dimetindene antihistamines was achieved by capillary electrophoresis using β-CD, DM-β-CD, and TM-β-CD in 50 mM phosphate buffer (pH 3.0), with an applied voltage of 20 kV, a temperature of 20°C, and UV detection at 220 nm. The migration times of the enanti... |
41635072 | Molecular Docking-Assisted Fluorescence Enhancement of Roflumilast Through Micellization: Whiteness and Greenness Evaluation With Pharmaceutical and Milk Applications. | This study introduces the first eco-friendly micellar method for the determination of roflumilast (ROL) in its pure form, pharmaceutical dosage form, and milk. A micellar solution of beta-cyclodextrin (ꞵCD) containing ROL showed high native fluorescence emission at 388 nm following excitation at 253 nm. Molecular docki... |
41635004 | Lignin Nanoparticles Containing Cobalt-Cyanine Complexes: Potential Multifunctional Platforms for Photoacoustic Imaging and Photothermal Treatment of Bacterial Biofilms in Chronic Wounds. | Chronic wounds (CWs) are characterized by persistent inflammation and bacterial biofilms, which hinder healing and contribute to antibiotic resistance. Therefore, innovative treatments with both anti-inflammatory and antibiofilm properties are urgently needed. Here, cobalt phthalocyanine (CoPc), a photo-excitable dye, ... |
41634982 | Sex-dependent role of 20-HETE synthesis in outcome from ischemic stroke in rats. | The lipid mediator 20-HETE is produced by ω-hydroxylation of arachidonic acid mediated by cytochrome P450 (CYP) enzymes including CYP4A, which has four distinct isoforms in rodents. Several laboratories demonstrated that 20-HETE synthesis inhibition reduces infarct volume following middle cerebral artery occlusion (MCA... |
41634977 | Development and Application of a Cumate-Inducible Promoter, P<sub>gc</sub>, in Komagataella pastoris. | Komagataella pastoris is extensively used as a microbial cell factory for the production of recombinant proteins and high-value compounds. However, tightly controlled promoter systems responsive to safe and economical inducers are required for precise metabolic and pathway engineering in this yeast species. Cumate-indu... |
41631821 | The future of Forkhead box O transcription factors. | The Forkhead box O (FOXO) class of transcription factors is evolutionary conserved both structurally and at least in part also functionally. FOXO activation results in transcriptional programs that provide cellular resilience toward exogenous and endogenous challenges, especially challenges that provoke cellular oxidat... |
41631809 | Microscopic structure of aqueous alkylamine mixtures: A computer simulation study. | We examine the microscopic origin of the pronounced x-ray scattering pre-peaks observed in water-rich aqueous alkylamine mixtures. While neat amines display weak pre-peaks compared to alcohols, and aqueous alcohols generally exhibit none, aqueous amines display a striking and unexpected signal. Molecular dynamics simul... |
41631805 | Photoelectron spectroscopy and structural characterization of [EDTA · M(II)]2- · nH2O (M = Ni, Cu, Zn; n = 0-2) complexes. | We investigated microhydrated transition metal-ethylenediaminetetraacetic acid (EDTA) dianion complexes [EDTA · M(II)]2- · nH2O (M = Ni, Cu, and Zn; n = 1, 2) using cryogenic photoelectron spectroscopy in conjunction with theoretical calculations. The measured spectra of [EDTA · Ni/Zn(II)]2- · nH2O closely resemble tho... |
41631790 | Assembly and Functional Coordination of Two Families of Metabolic Organelles in Salmonella. | Bacterial microcompartments (BMCs) are protein-based organelles that spatially organise metabolic pathways in prokaryotes, playing critical roles in enhancing metabolic processes and microbe fitness. Notably, many bacterial species possess multiple types of BMCs. While recent studies have advanced our knowledge about t... |
41629752 | Pharmacophore-Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases. | Neprilysin (NEP), a zinc-dependent metalloprotease involved in the degradation of bioactive peptides, represents a validated target for heart failure therapeutics. In this study, a pharmacophore-based virtual screening approach combined with biochemical and biophysical assays, alongside molecular dynamics (MD) simulati... |
41629224 | Modulating Copper Dispersion and Active Cu<sup>0</sup>/Cu<sup>+</sup> Sites in Cu/CeO<sub>2</sub> Catalysts Through Controlled Calcination Atmosphere for Efficient 5-Hydroxymethylfurfural Hydrogenation. | 2,5-Bis(hydroxymethyl)furan (BHMF) is a promising intermediate for the synthesis of pharmaceuticals and crown ethers, whereas achieving a high reaction rate in the hydrogenation of 5-hydroxymethylfurfural (5-HMF) to form BHMF remains challenge. In this work, a series of Cu/CeO<sub>2</sub>-x catalysts (x denotes H, Air,... |
41628557 | Electrochemical degradation of microcystin-LR in high-pH and high-DOC waters using a novel Au/Ni-MOF anode. | Microcystin-LR (MC-LR), a potent cyanotoxin produced during harmful algal blooms, poses serious threats to drinking and recreational waters, particularly under alkaline and organic-rich conditions where many treatment processes fail. This study demonstrates electrochemical degradation of MC-LR using a gold-decorated ni... |
41627133 | The Hydration Blueprint of Polylactic Acid: Computational Decoding of Noncovalent Interactions for Predictive Biodegradation. | The biodegradation of polylactic acid (PLA) is essentially controlled by its interaction with water although little is known about the molecular-level mechanisms that trigger hydrolysis. This limitation hinders the rational design of polymers with desired degradation kinetics. In this work, we unveil the hydration-indu... |
41622897 | Regulating Both In-Plane and Out-Of-Plane Supramolecular Interactions in COFs for Simultaneously Enhanced Crystallinity and Stability. | The demand for high-performance applications of covalent organic frameworks (COFs) under harsh conditions drives the need for reaching both outstanding crystallinity and high stability, while these two properties necessitate contradictory structural features and are thus challenging to achieve simultaneously. We herein... |
41622886 | A Metallosupramolecular Receptor for Squaraine Dyes Enabling Ultrafast Dark Resonance Energy Transfer. | A metal-organic cage was obtained by combining acridone-based dipyridyl ligands with Pd<sup>2+</sup> ions. The cage acts as a potent receptor for squaraine dyes, with a pronounced preference for guests with 2,6-dihydroxyphenyl substituents. This selectivity profile differs from that of previously reported receptors for... |
41622725 | Biocatalytic Synthesis of Diamondoid Diols by the Brown-Rot Fungus Wolfiporia cocos. | The CH-oxidative activity of Wolfiporia cocos cultures of different ages was studied utilizing diamondoid derivatives as conformationally rigid models. Adamantane-1-ol and 1-bromoadamantane, traditional precursors for the synthesis of polysubstituted adamantanes, gave qualitatively similar reaction mixtures in which ad... |
41622711 | Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects. | Bacterial infection remains a primary cause of delayed wound healing. It is one of the leading causes of post-surgical hospital readmission and is a major burden on global health systems. In light of the growing threat of antibiotic resistance, improving efficacy of traditional antimicrobials, such as the broad‑spectru... |
41622687 | Aptamer-Functionalized CuNPs for Label-Free and Highly-Sensitive Detection of Interleukin-6 Using a Light-Addressable Potentiometric Sensor. | Interleukin-6 (IL-6) is a crucial biomarker for monitoring inflammatory responses and chronic diseases, including cancer. In this work, we present a novel label-free aptasensor that combines copper nanoparticles (CuNPs) with a light-addressable potentiometric sensor (LAPS) platform, enabling the highly-sensitive detect... |
41622668 | Are Fewer Damage Control Laparotomies Associated with a Decrease in the Rate and Severity of Surgical Site Infections? | <h4>Background</h4>Damage control laparotomy (DCL) rates have declined and remained low. Given DCL's association with surgical site infections (SSIs), we hypothesize that SSI rates and severity, as per Clavien-Dindo (CD) classification, have decreased concurrently.<h4>Patients and methods</h4>A retrospective study was ... |
41622665 | Liver-on-a-Chip (LoC) Models: Case Studies of Academic Platforms and Commercial Products. | Pharmaceutical companies place significant importance on the liver due to its crucial role in numerous biochemical processes, specifically in drug metabolism. This focus has led to significant progress in liver-on-a-chip (LoC) technology, which has proven useful not only in drug development but also in more advanced ap... |
41622654 | Antiaromaticity Relief-Mediated Intramolecular Charge Transfer Enables Efficient and Stable Radical Emission in Polar Solvents. | Triphenylmethyl (trityl) radicals have shown potential for use in organic optoelectronic and spintronic applications. However, due to the poor luminescence of alternant symmetry hydrocarbons, the design of practical trityl structures has been limited to donor-radical intramolecular charge-transfer systems to break the ... |
41622634 | From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology. | Molecular glues represent a new paradigm in drug discovery, stabilizing novel protein-protein interactions between two proteins to elicit targeted cellular outcomes. Historically discovered through serendipity, molecular glue identification is becoming increasingly systematic. In this perspective, we discuss the curren... |
41622561 | Recent Advancements in Metal-Organic Framework-Based Photocatalysts for Environmental Remediation. | The rapid progression of industrialization has generated substantial environmental deterioration, posing significant threats to public health. Developing efficient and cost-effective strategies to combat environmental pollution is of paramount importance. Metal-organic frameworks (MOFs) have recently emerged as a versa... |
41622557 | Dynamic Color-Tunable Dual Room Temperature Phosphorescence via Activation of Both Host and Guest Triplet States. | The design of dual organic room-temperature phosphorescence (RTP) from both the host and guest remains a significant challenge, as most organic doping systems generally enable either the guest or the host to serve as a single static phosphorescent emitter. Here we report a host-guest dual RTP system featuring dynamical... |
41622522 | Mg-Based Metal-Organic Framework-Modified MXene Nanozymes as a Comprehensive Therapeutic for Rotator Cuff Tear with Osteoporosis. | Rotator cuff tears (RCT) are one of the most common causes of shoulder joint pain and mobility disorders affecting the health of middle-aged and elderly patients. Although the arthroscopic repair can effectively suture the torn rotator cuff, the retear rate is still high, especially for patients with osteoporosis. Exce... |
41622397 | IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273. | <h4>Introduction</h4>Detailed characterization of the antibody profile induced by SARS-CoV-2 mRNA vaccines has shown that repeat dosing boosts all immunoglobulin G (IgG) subclasses, with a notable emergence of antigen-specific IgG4 antibodies. While the IgG4 subclass is traditionally associated with limited Fc-effector... |
41622236 | Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy. | Characterizing the tumor immune microenvironment (TIME) to explore potential therapeutic targets is fundamental to advancing precision tumor immunotherapy. However, the immunosuppressive nature of "cold" tumors, notably prostate cancer, poses a significant barrier to immunotherapy, demanding new approaches to simultane... |
41622222 | HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy. | Limited intensity and duration of high-intensity focused ultrasound (HIFU)-induced immune response largely hinder postoperative immunotherapy due to low immunogenicity and immunosuppression of tumor microenvironment (TME). In this study, effect-specific metal-organic frameworks (MOFs) were designed based on the severe ... |
41622179 | Research progress of nanoparticles in the diagnosis and treatment of renal ischemia-reperfusion injury. | Renal ischemia-reperfusion injury (RIRI) is a prevalent and damaging pathological process in clinical practice, significantly impairing renal recovery and long-term prognosis. The pathogenesis of IRI involves multiple factors, including oxidative stress, inflammatory activation, cell death pathways, and microcirculator... |
41621851 | Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T. | <h4>Purpose</h4>The aim was to estimate T1 relaxivity of gadobutrol and gadoteric acid in cerebrospinal fluid (CSF) at 3T, to support research on CSF-flow and the glymphatic system in humans utilizing T1 mapping after intrathecal injection.<h4>Methods</h4>Using a phantom, relaxivity was estimated for gadobutrol and gad... |
41621043 | The Metal-Organic Framework NH<sub>2</sub>-MIL-101(Fe) Modulates Arsenate Bioaccumulation, Biotransformation, Trophic Transfer, and Mitochondrial Genotoxicity in <i>Daphnia magna</i>-Zebrafish Food Chain. | Metal-organic frameworks (MOFs) are promising adsorbents for arsenate (As(V)) remediation; however, their ecological risks during co-occurrence with As(V) in aquatic ecosystems remain poorly understood. This study investigated the effects of NH<sub>2</sub>-MIL-101(Fe) on As(V) bioaccumulation, trophic transfer, biotran... |
41621019 | Enzymatic preparation of epigallocatechin gallate diglucoside and bioactivity assessment. | Epigallocatechin gallate (EGCG), the predominant catechin in green tea, has limited application due to its poor water solubility and instability. To address these issues, this study utilized recombinant sucrose phosphorylase to catalyze the glucosylation of EGCG, successfully synthesizing (-)-epigallocatechin gallate 4... |
41620547 | Advances in photoacoustic imaging reconstruction and quantitative analysis for biomedical applications. | Photoacoustic imaging (PAI), a modality that combines the high contrast of optical imaging with the deep penetration of ultrasound, is rapidly transitioning from preclinical research to clinical practice. However, its widespread clinical adoption faces challenges such as the inherent trade-off between penetration depth... |
41619307 | Biosynthesis of Silver Nanoparticles Using Black Pepper (Piper nigrum) Seed Extract and Evaluation of Their Cytotoxicity. | The green synthesis of silver nanoparticles (AgNPs) offers an environmentally friendly alternative to conventional methods by replacing toxic chemical reagents with natural sources. These methods utilize microorganisms, such as bacteria and fungi, or natural plant extracts rich in secondary metabolites that act as redu... |
41618970 | Anthracene-Bridged Cyclo[3]Dipyrrin Exhibiting Induced Chirality and Its Conformationally Asymmetric Tris-BODIPY Derivative. | This work explores the synthesis of Cyclo[3]mer 1a obtained by the acid-catalyzed condensation reaction of 1,5-di(1H-pyrrol-2-yl)anthracene with pentafluorobenzaldehyde in the presence of trifluoroacetic acid. Because of the larger cavity size and multiple sites for coordination, cyclo[3]mer underwent smooth BF2 comple... |
41618834 | One-Reactor Upcycling of Waste Polyesters into Functional MOFs for Passive Radiative Cooling. | Polyethylene terephthalate (PET), despite its extensive use, presents serious environmental concerns due to inefficient recycling and inevitable downcycling. In this work, a sustainable one-reactor upcycling strategy is developed to directly convert waste PET into functional metal-organic frameworks (MOFs). Using a bio... |
41618614 | Exploiting Paraphaeosphaeria minitans and Its Antifungal Metabolites as Bio-Fungicides for Eco-Friendly Management of Head Rot Disease in Cabbage. | Cabbage head rot, caused by Sclerotinia sclerotiorum, threatens crop yield and quality. Among the 21 mycoparasitic fungi isolated from sclerotia, dormant structure and primary sources of inoculum for the pathogen, the strongest antagonism (78.51% mycelial growth inhibition) was observed in Paraphaeosphaeria minitans st... |
41605875 | TRPM8 Regulates Mitochondrial Ca<sup>2+</sup>-Dynamics, Temperature and Endoplasmic Reticulum-Mitochondrial Contact Points in T Cell. | TRPM8 is a cold temperature-sensitive and non-selective Ca<sup>2+</sup>-channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub-cellular compartments. Pharmacological modulati... |
41614380 | From Ink to Mockup: An Integrated Study of Historical Gall Ink Formulations and Their Impact on Paper. | Iron gall inks (IGIs) played a central role as a writing medium in Western countries, leaving behind a vast legacy and significant conservation challenges. This study presents a twofold methodological approach to investigate the physicochemical behaviour of IGI-based formulations found in historical Portuguese sources.... |
41614214 | FAST - filamentous actin segmentation tool for quantifying cytoskeletal organization. | Studying how actin filaments are assembled into different subcellular structures can provide insights into both physiological processes and the mechanisms of disease. However, quantifying the size, abundance and organization of different classes of actin structure from optical microscopy data remains a challenge. To ad... |
41609942 | Rapid, Scalable, and Cost-Effective Manufacturing of Uniform Non-Enveloped, Tag-Free Virus-Like Particles. | Virus-like particles (VLPs) are widely recognized as safe and versatile nanostructures with broad applications in vaccine development, gene delivery, and nanotechnology, but their production typically requires time-consuming procedures, incurs high costs, and yields products of limited purity. This article outlines a r... |
41608764 | Bispecific Antibodies Versus Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Comparative Narrative Review of Efficacy, Safety, and Accessibility. | <h4>Introduction</h4>Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, and despite advances in frontline therapies such as rituximab, cyclophosphamide, doxorubicin hydrochloride (hydroxydaunorubicin), vincristine sulfate (Oncovin), and prednisone, approximately 30%-40% of patient... |
41603290 | Optimized ACE2-Fc fusion proteins with picomolar neutralization activity against highly evolved SARS-CoV-2 variants. | The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised the efficacy of many authorized monoclonal antibody products. This highlights the need for alternative strategies, especially for vulnerable populations such as immunocompromised individuals. Here, we optimized angiotens... |
41601354 | deltaHED predicts survival and immune evasion in PD-1 blockade therapy: A multi-cohort study across three cancer types. | The prognostic relevance of HLA class I (HLA-I)-mediated immunity in cancer immunotherapy remains unclear. We introduce deltaHED, a novel metric that quantifies evolutionary divergence between germline and tumour-acquired HLA-I alleles, integrating both inherited and somatic immunogenetic variation. Using whole-exome s... |
41601343 | Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic-cell clearance to therapeutic targeting. | <h4>Background</h4>Efferocytosis is a critical physiological process in which phagocytes clear apoptotic cells to maintain tissue homeostasis. However, within the tumour microenvironment (TME), this process is systematically hijacked by tumour cells, transforming it into a key pathological mechanism that drives immunos... |
41578973 | Cardiomyopathy-associated and basic residue mutations in myopalladin alter actin binding, bundling, and structural stability. | Myopalladin (MYPN) is a striated muscle-specific protein essential for sarcomere integrity and actin filament organization. The Ig3 domain of MYPN mediates direct binding and bundling of filamentous actin (F-actin), and several cardiomyopathy (CM)-associated mutations cluster within this domain. To elucidate the molecu... |
41578971 | Guiding AlphaFold predictions with experimental knowledge to inform dynamics and interactions with VAIRO. | Structural predictions have reached unprecedented accuracy. They leverage sequence-specific data to capture all potential interactions a sequence has evolved to fulfill. AlphaFold derives information from three sources: learned parameters capturing intrinsic amino acid secondary structure and environment propensity; mo... |
41569631 | Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein. | Gallid alphaherpesvirus 1 (GaAHV-1), also referred to as infectious laryngotracheitis virus (ILTV), primarily targets the upper respiratory tract of chickens. This infection leads to significant economic setbacks worldwide in the poultry sector, driven by reductions in egg output, weight gain, and increased mortality r... |
41566926 | Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiota Dysbiosis and Short-Chain Fatty Acid Profiling. | On the basis of gut microbiota and short-chain fatty acids (SCFAs), this study aims to identify diagnostic biomarkers for damp-heat diarrhea and cold-damp diarrhea. Rat models of damp-heat diarrhea and cold-damp diarrhea were established. Changes in body weight, body temperature, food intake, water consumption, and the... |
41559010 | Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors. | G protein-coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody-based therapies. This review offers an overview of the therapeutic GPCR-antibody target landscape and ex... |
41556522 | Structural and dynamic similarities of nanofibrils and microparticles of engineered spider silk proteins probed by solid-state NMR spectroscopy. | Spider silks are proteinaceous fiber materials inspiring material design in various technical and biomedical fields due to their exceptional toughness, which exceeds that of most natural and artificial fibers. Solid-state nuclear magnetic resonance (NMR) spectroscopy has been used herein to obtain insights into the str... |
41556494 | Modulation of succinyl-CoA:3-ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness. | Trypanosomatids are protozoan parasites that remain a global health challenge due to the limited efficacy, safety, and durability of current treatments. Acetate: succinate CoA transferase (ASCT), together with succinyl-CoA synthase (SCS), forms the ASCT/SCS cycle that fuels ATP production and generates acetate, a centr... |
41556436 | Heat shock protein 10 as a chaperone modulating α-synuclein amyloid fibril formation. | HSP10 is a well-known human co-chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins. Using a variety of biophysical and... |
41555529 | Emergence of the novel PA-D27G mutation conferring reduced baloxavir susceptibility in influenza A viruses circulating in China, 2018-2025. | Seasonal influenza A viruses evolve rapidly, yet the emergence and molecular basis of resistance to the polymerase acidic (PA) inhibitor baloxavir marboxil (BXM), which is widely used in China, remain elusive. To address this, 3938 PA gene sequences were collected from influenza patients across mainland China between 2... |
41555497 | Uniform design-embedded predictions of (tetra-)peptide physicochemical properties. | <h4>Motivation</h4>Short peptides hold significant promise in drug discovery and materials science due to their biocompatibility, multifunctionality, ease of synthesis, etc. However, accurately predicting their physicochemical properties, a prerequisite for application development, remains a grand challenge due to the ... |
41540656 | Synchrotron Radiation Circular Dichroism of a Water-Soluble Cryptophane. | We report the study of the two enantiomers of the water-soluble cryptophane 1 by Synchrotron Radiation Circular Dichroism (SRCD) in DMSO, LiOH/H<sub>2</sub>O, NaOH/H<sub>2</sub>O, KOH/H<sub>2</sub>O, and CsOH/H<sub>2</sub>O solutions. Interestingly, SRCD gives access to new Cotton bands that could not be detected with ... |
41498377 | Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling. | Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life-threatening cardiac complications by adolescence. Current treatments fail to prevent poor prognoses, a... |
41498337 | De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3. | Receptor interacting protein kinase 3 (RIPK3) is a central regulator of necroptosis and a key mediator of inflammatory signalling. Its function is orchestrated through RIP homotypic interaction motif (RHIM)-dependent interactions with other RHIM-containing adapter proteins, forming amyloid-structured necrosomes that tr... |
41457060 | Nanomedicine Strategies Against Biofilm-Associated Infections: Advances, Challenges, and Translational Barriers. | Antimicrobial resistance continues to rise globally, with biofilm-associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses. Biofilms, structured microbial communities embedded in a protective extracellular matrix, underlie many chronic and recurr... |
41412558 | On-Resin Pictet-Spengler Cyclization for 1,2,3,4-Tetrahydro-β-carboline-3-carboxylate (Tcc) Peptide Synthesis With Acid-Labile Functional Tolerance. | The constrained tryptophan (Trp) analog 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (Tcc) is used to restrict peptide conformation in structure-activity relationship studies. Although Pictet-Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid-la... |
41408721 | Spine age derived from DXA vertebral fracture assessment images predicts incident fractures and mortality: the Manitoba Bone Mineral Density Registry. | Biological age may better predict health outcomes than chronological age by capturing individual heterogeneity in aging. We investigated whether accelerated spine aging, estimated from DXA vertebral fracture assessment (VFA) using deep learning, predicts fracture and mortality independently of age, vertebral fracture (... |
41407320 | Multi-layered gene regulation by long non-coding RNAs: from chromatin to genome architecture. | Long non-coding RNAs (lncRNAs) are now recognized as pivotal regulators that enable the fine-tuned control of gene expression. While the functional diversity of lncRNAs challenges comprehensive understanding of their mechanisms, recent advances have revealed how these molecules coordinate epigenomic control, ranging fr... |
41396694 | Potent Therapeutic Efficacy of 9-Bromo-Noscapine Against Breast Cancer Cells Via Enhanced Bioavailability of the Noscapine-Cyclodextrin Inclusion Complex. | The poor bioavailability and low therapeutic indices of conventional cancer therapeutics hinder their efficacy despite their promising anticancer potential. This study presents an improved solubility and enhanced drug delivery system against breast cancer by complexing Bromo-Noscapine (9-Br-Nos) with Methyl-β-cyclodext... |
41324594 | FLT3-directed BiTE molecules vs CAR T cells in AML: costimulatory signals mitigate T-cell exhaustion. | <h4>Abstract</h4>T-cell-based immunotherapies have revolutionized treatment paradigms in B-cell malignancies, yet their translation to acute myeloid leukemia (AML) has been hindered by a scarcity of tumor-restricted antigens and the risk of on-target off-leukemia toxicity. FLT3 has emerged as a promising therapeutic ta... |
41129140 | Dual Inhibitors of KRASG12D and HSP90 Are Effective against KRASG12D Inhibitor Resistance. | KRAS G12D is a common oncogenic driver mutation in diverse cancers, including non-small cell lung cancer, colorectal cancer, and pancreatic cancer. KRASG12D inhibitors have recently progressed into clinical trials but will likely face innate or acquired drug resistance similar to that which has been observed for KRASG1... |
41053975 | Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth. | Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA polymerase I, against pancreatic cancer by uncovering a novel molecular mechanism inv... |
40981426 | The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer. | The combination of 5-fluorouracil and irinotecan (FOLFIRI) remains a standard-of-care treatment for metastatic colorectal cancer (mCRC) yet benefits only about half of patients. Using patient-derived xenografts, we investigated the biological underpinnings of this heterogeneous response. FOLFIRI-resistant models showed... |
40972654 | Identification of causal agent of gray blight disease in Camellia sinensis and screening of resistance cultivars. | Tea gray blight disease represents a major fungal threat to tea plants, leading to substantial reductions in yield and declines in quality. It is prevalent in tea plantations globally. Given the considerable genetic diversity of pathogen populations across various tea-growing regions, understanding the population struc... |
40910397 | Clinical Utility of Salivary Steroid Profiling for the Differential Diagnosis of Adrenal Diseases. | <h4>Context</h4>Although salivary steroid sampling offers several advantages, the diagnostic potential of salivary steroid metabolites remains largely unexplored.<h4>Objective</h4>This work aimed to evaluate the diagnostic utility of salivary steroid profiling in patients with adrenal diseases.<h4>Methods</h4>This pros... |
40827670 | Fracture risk scores using output from an opportunistic screen of low bone density from conventional X-ray. | Fracture risk is commonly assessed by FRAX, a tool that estimates 10-yr risk for major osteoporotic fracture (MOF) and hip fracture. FRAX scores are often refined by including FN BMD measured by DXA as an input. Rho, a novel AI-powered software, estimates FN BMD T-Scores from conventional X-rays, even when FN is not in... |
40827677 | Increase in serum DKK1 levels attenuates the anabolic response to romosozumab in postmenopausal osteoporosis. | Romosozumab is a monoclonal antibody against sclerostin that initially exhibits potent anabolic effects in treating osteoporosis. However, its efficacy diminishes after 6 mo, with bone formation markers declining despite continued therapy. We hypothesized that increased levels of Dickkopf-1 (Dkk1), a Wnt pathway inhibi... |
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