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40825049 | Postoperative benefits of sugammadex: A narrative review. | <h4>Purpose</h4>To describe the systemic benefits of sugammadex as a reversal agent for neuromuscular blockade.<h4>Summary</h4>Sugammadex is the preferred reversal agent for neuromuscular blockade as recommended in guidelines from the American Society of Anesthesiology. This recommendation is primarily based on a faste... |
40823712 | Longitudinal associations between changes in bone mechanical strength and fracture risk estimated by μFRAC. | Monitoring bone health for osteoporosis is typically based on measuring areal BMD. However, widely used fracture risk prediction tools are primarily driven by clinical risk factors and show limited sensitivity to underlying bone changes over time. This study evaluated the ability of the new Microarchitecture Fracture R... |
41960516 | Emerging trends in enamel remineralization. | The enamel of our teeth is heavily mineralized and undergoes repeated cycles of demineralization and remineralization. Despite long- term use of fluorides, ACP-CPP and bioactive glass as remineralizing agents, their limited properties prevent complete restoration of the enamel's hierarchical structure, leading to the i... |
41960449 | Clinical evaluation of open flap debridement with or without Emdogain® in treating intrabony defects. | Periodontitis causes intrabony defects and while open flap debridement (OFD) with EMD and GTR shows promise, the comparative effectiveness of EMD in treating these defects remains underexplored. Open flap debridement (OFD) or access flap surgery is used in conjunction with biological factors such as enamel matrix deriv... |
41852595 | Non-doped hot-exciton blue organic light-emitting diodes with efficiency over 20. | Host-guest doping is the mainstream technology for organic light-emitting diodes (OLEDs). Non-doped OLEDs, using a single material for both electron migration and exciton luminescence, promise simplified preparation, but lack efficient emitting-layer materials due to the concentration quenching of excitons (especially ... |
41822585 | Immunoinformatics-driven design of a conserved RNA-dependent RNA polymerase-based multi-epitope vaccine against avian infectious bronchitis virus. | <h4>Background and aim</h4>Avian infectious bronchitis virus (IBV) is a highly contagious coronavirus that causes severe respiratory, renal, and reproductive disease in chickens, resulting in significant economic losses in the poultry industry worldwide. The high mutation and recombination rates of IBV, especially in s... |
41809029 | Recent advancements in biomass-origin carbon structures for next-generation supercapacitors. | The urgent global need for efficient, clean, and sustainable energy storage technologies has underscored the importance of supercapacitors as vital components in future energy systems. Their high power density, excellent cycle life, and rapid charge-discharge capabilities make them particularly attractive for diverse s... |
41798890 | Macrophage Immune-Competent Colon Assembloids for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility. | <h4>Background and aims</h4>Background and Aims: Functional gastrointestinal disorders affect ∼40% of the global population and are frequently characterized by colonic dysmotility. Symptomatic manifestations of colonic dysmotility significantly reduce quality of life in inflammatory bowel disease, diabetes, and Gulf Wa... |
41782786 | Molecular Effect of Tobacco on Genetic, Epigenetic, and Metabolic Pathways During Cancer Progression. | Tobacco consumption remains a leading global health challenge, driving chronic diseases such as cancer, cardiovascular disorders, and metabolic dysfunction through intricate molecular mechanisms. This study investigates the multifaceted effects of tobacco exposure on genetic, epigenetic, and metabolic pathways, focusin... |
41754932 | Camptothecin-Bearing PEGylated Polypropylenimine Dendriplexes for Prostate Cancer Gene Therapy: Impact of Microfluidic Processing on Physicochemical Properties and Transfection. | <b>Background/Objectives:</b> Prostate cancer is the most commonly diagnosed cancer in men and a leading cause of cancer-related mortality, highlighting the need for delivery systems capable of efficiently transporting both chemotherapeutic drugs and therapeutic genes to tumor cells. Generation-3 diaminobutyric polypro... |
41744707 | Acoustic Bubble Sensing Techniques and Bioapplications. | Acoustic bubbles are emerging as powerful microscale sensors that convert local biochemical and biomechanical cues into measurable signals in a remote, label-free, and clinically compatible manner. Originally developed as vascular contrast agents, microbubbles are now engineered so that their resonance frequency, nonli... |
41726626 | <i>In Vitro</i> Antimicrobial Evaluation of Silver Nanoparticles in Lyotropic Liquid Crystals for Cutaneous Wound Treatment. | Complex wounds, burns, and diabetic complications increase patients' susceptibility to bacterial infections, which frequently show resistance to standard treatments. This investigation focused on evaluating the antimicrobial potential of lyotropic liquid crystal (LC) formulations loaded with silver nanoparticles (AgNPs... |
41704397 | Induced-proximity therapeutics for targeted protein and RNA degradation: An organic chemistry Perspective-A review. | Induced-proximity therapeutics have emerged as a transformative paradigm in chemical biology and drug discovery, enabling selective control of cellular processes beyond conventional inhibitors. Between 2020 and 2025, major progress has been achieved across five modalities: proteolysis-targeting chimeras (PROTACs), mole... |
41696149 | An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzheimer's disease therapy. | β-amyloid (Aβ) inhibition significantly attenuates the early-stage Alzheimer's disease (AD) progression, but the improvement in cognitive function remains limited by neuroinflammation. Here, we developed a bioinspired neuroenhancer that concurrently targets both Aβ aggregation and neuroinflammation. Rutin and small int... |
41685211 | Effects of endogenous walnut pellicle polyphenols on the structure and functional properties of walnut meal isolate proteins. | This study aims to investigate how endogenous walnut pellicle polyphenols (WPP) alter the structural and functional properties of walnut protein isolate (WalPI). WPP influence was assessed by adjusting polyphenol content in walnut meal (WM) through treatments that peeled and dephenolized the pellicle. Results showed th... |
41683870 | Chemical Profiling, Ampicillin Interaction Patterns, and Exploratory Molecular Docking of <i>Lauraceae</i> Essential Oils. | This study compares the chemical composition, antimicrobial effects, and antibiotic-potentiating capacity of three <i>Lauraceae</i> essential oils (EO): <i>Cryptocarya agathophylla</i> (CAEO), <i>Litsea cubeba</i> (LCEO), and <i>Laurus nobilis</i> (LNEO). Gas chromatography-mass spectrometry (GC-MS) analysis revealed d... |
41683868 | Morphology-Driven Enhancement of Alkaline OER Performance in Spinel NiCo<sub>2</sub>O<sub>4</sub> Nanosheet Electrodes. | The oxygen evolution reaction (OER) is a critical anodic process in alkaline water electrolysis, and its catalytic performance can be effectively regulated through rational morphology engineering that governs active-site exposure, mass transport, and charge-transfer kinetics. Herein, we report a precursor-controlled sy... |
41683858 | Carbon Dots Meet MRI: Metal Doping for a Smart Contrast Agent Design. | In clinical and preclinical magnetic resonance imaging (MRI), image quality is often limited by intrinsic tissue contrast, so paramagnetic agents are used to amplify relaxation differences and improve lesion detectability. Widely used gadolinium-based contrast agents present recognized drawbacks, stimulating interest i... |
41683479 | Tecovirimat-Related Substance: Characterization, Hirshfeld Analysis, Theoretical Study, In Silico Toxicity Assessment. | Crystal structures of 4-(trifluoromethyl)benzene-1-carbohydrazide (<b>1</b>), 4-(trifluoromethyl)-N'-{[4-(trifluoromethyl)phenyl]carbonyl}benzohydrazide (<b>2</b>) and (1<i>R</i>,2<i>S</i>,6<i>R</i>,7<i>S</i>,8<i>S</i>,10<i>R</i>)-4-({[4-(trifluoromethyl)phenyl]carbonyl}amino)-4-azatetracyclo [5.3.2.0<sup>8,10</sup>.0<... |
41683072 | Chitosan-Based Composite Films Reinforced with Zein-Inulin-Thyme Essential Oil Pickering Emulsion for Enhanced Structural Integrity and Preservation Capacity. | Herein, zein-inulin-stabilized thyme essential oil (TEO) Pickering emulsions were prepared via ultrasonication. The addition of inulin (0.12-0.5%) enhanced emulsion stability and antibacterial activity, with particle sizes ranging from 73.7 to 789.8 nm. Chitosan (CS) composite films were then fabricated using different... |
41682096 | Preparation and Research Progress of Polymer-Based Anion Exchange Chromatography Stationary Phases. | Ion chromatography (IC) serves as a pivotal technique in trace ion analysis, and the separation performance of IC is largely determined by the properties of stationary phases. In contrast to silica-based matrices, polymer-based stationary phases have garnered significant interest owing to their outstanding pH stability... |
41682093 | Ciprofloxacin-Imprinted Polymers: Synthesis, Characterization, and Applications. | Ciprofloxacin, being a widely used antibiotic agent, has sparked growing interest in the field of molecularly imprinted polymers (MIP) for its selective recognition and removal. This review provides a comprehensive analysis of the recent advances in the synthesis and applications of ciprofloxacin-imprinted polymers. Th... |
41682090 | Sensitive Montmorillonite Evaporation Detector Based on Montmorillonite Monolayer Nanosheets. | Two-dimensional (2D) materials open up exciting possibilities for the study of ion transport behavior for green energy. Here, a simple and effective strategy to fabricate high-conductivity nanofluidic channels based on exfoliated montmorillonite (MTM) nanosheets is proposed. The resource-rich and low-cost layered MTM w... |
41681608 | Comparative Effects of Biostimulants and Fruit Enlargement Agents on Fruit Quality in Two Kiwifruit Cultivars. | Biostimulants have been increasingly investigated as eco-friendly alternatives to synthetic fruit enlargement agents in horticulture. In this study, two commercially cultivated kiwifruit cultivars, Zhongmi No. 2 and Jintao, were used as experimental materials. Three biostimulant products with distinct functional compos... |
41681605 | <i>Ent</i>-Clerodane Diterpenoid Inhibitors of Glucose-6-phosphatase from <i>Croton guatemalensis</i> Lotsy. | The Croton genus includes a diverse group of plants with remarkable potential in natural products research, particularly due to their bioactive compounds with hypoglycemic and phytochemical significance. This study examines <i>Croton guatemalensis</i> Lotsy, focusing on its chemical composition and its biological effic... |
41650776 | Structural elucidation and quantitative analysis of cinnamic acid derivatives using TIMS-MS, cyclodextrin adducts, and computational chemistry. | This study developed a rapid TIMS-MS method combined with computational chemistry to differentiate and quantify three groups of cinnamic acid derivative (CAD) isomers: 2/4- hydroxycinnamic acid (2/4-HCA), α/β-methylcinnamic acid (α/β-MCA), and o/m/p- Methoxycinnamic acid (o/m/p-MCA). Separation leveraged distinct non-c... |
41643631 | Modulation of the photodynamic activity of a cinnamoyl-coumarin-RGD peptide conjugate via cucurbit[8]uril supramolecular assembly. | Peptide-based photosensitizers (PSs) have emerged as a powerful strategy to overcome the limitations of conventional PSs in photodynamic therapy (PDT), including poor water solubility, low selectivity, and limited phototoxic efficiency. In this study, we synthesized and characterized a novel cinnamoyl-coumarin-RGD pept... |
41643625 | Light-driven host-guest supramolecular transport engineering an antibacterial trap switch. | Inspired by nature's sophisticated use of light energy, we report a bioinspired antibacterial trap switch operating without exogenous competitors. This work engineers a light-gated supramolecular system where host-guest conformational reorganization between cucurbit[8]uril (CB[8]) and dicationic symmetric azobenzene de... |
41641804 | Cocrystals of cyanuric acid with di(pyridin-4-yl)sulfane and 1,2-di(pyridin-4-yl)disulfane obtained from 4-mercaptopyridine under controlled illumination conditions. | Mercaptopyridines, heteroaromatic compounds containing thiol groups, are widely studied for their applications in coordination chemistry, supramolecular design and materials science due to their selective binding properties and photoresponsiveness. In this work, we investigated the crystallization of 4-mercaptopyridine... |
41638007 | Unveiling the chemical composition of a microbiota-derived extracellular polymeric substance and its antivirulence potential against Staphylococcus aureus from bovine mastitis. | Bovine mastitis caused by Staphylococcus aureus represents a major economic and health challenge in the dairy industry due to the pathogen's virulence factors and biofilm-forming ability, which confer resistance to conventional antibiotics. Sustainable alternatives are therefore urgently needed in the context of rising... |
41628879 | In situ self-assembly synthesis of ZIF-8-poly(acrylamide-co-vinylimidazole)/sodium alginate composite hydrogel for Cu<sup>2+</sup> removal. | Heavy metal ion pollution in wastewater, particularly Cu<sup>2+</sup> contamination, threatens ecology and human health, demanding efficient adsorption materials in environmental remediation. However, conventional adsorbents suffer from insufficient capacity, poor mechanical stability, weak selectivity, and low reusabi... |
41628746 | Dextran-engineered smart nanosystems for intelligent tumor drug targeting. | Cancer therapy increasingly relies on nanoscale delivery systems that exploit interfacial and colloidal phenomena to enhance drug bioavailability, stability, and selectivity. Dextran-based nanocarriers have attracted considerable attention as multifunctional drug delivery platforms due to their inherent hydrophilicity,... |
41624691 | Synthesis, Topological, and Biological Studies of a Novel One-Dimensional Hg(II) Coordination Polymer With Antibacterial and Anticancer Potentials. | A novel one-dimensional mercury coordination polymer (CP), identified as [(μ<sub>2</sub>-Cl)(Ina)Hg(μ<sub>3</sub>-Cl)Hg(μ<sub>2</sub>-Cl)<sub>2</sub>(Ina)]<sub>n</sub> (<b>1</b>) (where Ina represents isonicotinic acid or 4-pyridinecarboxylic acid), was synthesized via the interaction of isonicotinic acid with mercury(... |
41623554 | Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE-Mediated IFN Pathway and NF-κB Signal. | Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot-and-mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myrista... |
41621288 | Rapid urine screening and staging of chronic kidney disease via NAD(P)H-activated dual-salt fluorescent probe. | Chronic kidney disease (CKD) requires fast, noninvasive tools for early detection and staging that go beyond conventional serum creatinine/eGFR measurements. NAD(P)H, a key coenzyme in cellular metabolism, energy transfer, and redox signaling, is closely associated with the normal kidney function. Monitoring intracellu... |
41620603 | Synthesis, X-ray, molecular electronic property investigation, and molecular docking analysis of two imino Schiff bases. | In this study, we report the first synthesis and comprehensive characterization of two positional isomers of iodo-substituted imino Schiff bases, Im1 was synthesized using 2-iodoaniline, whereas Im2 was obtained from 4-iodoaniline. Compound Im1 represents a new derivative, while Im2 is fully characterized crystallograp... |
41620522 | Comparative entropy analysis of 2D transition metal tetrahydroxyquinones via machine learning approaches. | This paper focuses on the study of the framework of transition metal tetrahydroxyquinone (TM-THQ) which is a chemical belonging to the metal-organic framework (MOF) family. These materials are becoming relevant due to their stability and high surface area that makes them prospective in terms of carbon-dioxide conversio... |
41620500 | Carbon nanoparticles and diatomaceous earth hybrids: A synergistic approach for methylene blue uptake. | This study reports the methylene blue (MB) uptake capacity and absorption kinetics of adsorbents obtained by the hybridisation of natural diatomaceous earth with hydrophilic carbon nanoparticles at two different loadings (2 and 5 wt.%). The materials were characterized and tested as adsorbents of MB in acidic and basic... |
41620430 | Brexanolone infusion produces sustained anti-inflammatory and neurotrophic effects in patients with postpartum depression that predict symptom improvement. | Postpartum depression (PPD) is linked to neuroimmune dysregulation. Brexanolone, an intravenous formulation of the neurosteroid allopregnanolone and the first FDA-approved treatment for PPD, produces rapid and sustained antidepressant effects. However, its long-term mechanisms of action remain unclear. This study evalu... |
41620414 | Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals. | Hierarchical immobilization of multicomponent biomacromolecules has been demonstrated to be a favorable protocol for constructing advanced biopharmaceuticals, but still with formidable challenges. Herein, we innovate a multicomponent synergistic immobilization approach combining an in-situ method with a structural-tran... |
41620407 | Ultralow CNT-reinforced phase-change fibers for scalable wearable thermoregulation. | Phase-change materials (PCMs) demonstrate transformative potential for wearable thermal management systems; however, their practical implementation faces challenges due to trade-offs among energy storage density, mechanical robustness, and phase-change stability. Here, we present a nanotechnology-directed strategy that... |
41620411 | Tomato antiviral ubiquitin-proteasome system recognizes viral 59 kDa protein to confer tomato chlorosis virus resistance. | Viral diseases critically impact crop yields, necessitating insights into plant-pathogen recognition and resistance. In tomato (Solanum lycopersicum), tomato chlorosis virus (ToCV) employs 59 kDa protein (p59) to facilitate movement and degrade the host Catalase1 (SlCAT1), disrupting redox homeostasis. Importantly, tom... |
41620403 | Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial. | HIV persistence in reservoirs despite antiretroviral therapy (ART) is a barrier to a permanent cure. We present the affinity-enhanced TCR bispecific IMC-M113V as a potential therapeutic for targeted HIV reservoir elimination. Preclinical studies demonstrate that IMC-M113V redirects T cells towards cells expressing the ... |
41619262 | Gram-Scale Synthesis of Hafnium-Rich Carbon Dots for Preclinical Computed Tomography Imaging Across Various Systems. | Hafnium (Hf) has emerged as a promising element for next-generation computed tomography (CT) contrast agents owing to its high X-ray attenuation coefficient and favorable biocompatibility. However, scalable synthesis of Hf-based imaging probes with sufficiently high metal content for large-animal preclinical studies re... |
41619261 | A Glucose-Responsive Intelligent Antibacterial and Oxygen-Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity. | The chronic and refractory infected wounds of diabetes are primarily attributed to the persistent bacterial infection and the inhibition of wound healing caused by hypoxia. Hydrogel with intelligent drug delivery systems hold significant potential in the treatment of diabetic wounds. Herein, we have developed an glucos... |
41605259 | Non-coding small RNAs buffer protein interactions to prevent oncogenic aggregation: structural dampening of aberrant PPIs by RNA. | Non-coding RNAs (ncRNAs) modulate protein-protein interactions (PPIs) by shaping the structural context in which binding occurs, rather than acting as direct inhibitors or enhancers. Using an integrative framework combining catRAPID RNA-protein interaction prediction and AlphaFold3-based structural modelling, we analys... |
41619178 | Hydrogels Incorporating Donor-Acceptor Stenhouse Adducts as a Platform for Photoinduced, On-Off Switchable Release of Small Molecule Cargos. | Modulating biomaterial properties using light holds great promise for biomedical applications, such as drug delivery, as it is non-invasive and offers both spatial and temporal control. Visible light is particularly salient for stimulation of cell-interfacing materials, as it is cyto-compatible; however, this limits th... |
41618933 | Two-Dimensional Metal-Organic Framework for Supercapacitors: Thickness-Dependent Charge Storage Mechanisms. | Additive-free active materials are desirable for energy storage devices as they reduce processing complexity and eliminate variability from binders or conductive additives. We report the synthesis of a highly stable, two-dimensional copper-based metal-organic framework (CuMOF) film with a tunable thickness. The excepti... |
41618918 | Engineering Adaptive Hydrogen Bond Networks in Metal-Organic Frameworks for Bioinspired H<sub>2</sub>O<sub>2</sub> Catalysis Enhancement. | Dynamic hydrogen bond networks are integral to enzymatic catalysis, enabling efficient substrate polarization, intermediate stabilization, and rapid active-site turnover. However, translating such adaptive features into synthetic systems at the nanoscale presents a significant challenge. Here, we report a rationally de... |
41618913 | Rules for Dibenzocyclooctadiene Conformational Dynamics. | The conformational dynamics of flexible compounds can meaningfully influence their NMR spectra and biological activities, yet these effects are easily overlooked. The dibenzocyclooctadiene lignans provide a clear example of this. Although >350 naturally occurring dibenzocyclooctadienes have been published, discrete spe... |
41618886 | Dynamic Proton Extraction from Supramolecular Functionalized Metal-Organic Framework/Ti<sub>3</sub>C<sub>2</sub> MXene Hybrids for Efficient Solar Ammonia Synthesis. | In N<sub>2</sub> photoreduction, photogenerated holes and electrons are involved in H<sub>2</sub>O photolysis for proton supply and the weakening of the N≡N triple bond for N<sub>2</sub> activation, respectively. Rationally regulating the structure-activity relationship of these catalytic sites for available generation... |
41618884 | An Adaptive Trimodal Bioanalysis System via Heterogeneous Interface Engineering and Enzyme-Powered Molecular Machines. | This study reports a trimodal biosensing platform centered on an adaptive signal-fusion strategy for the ultrasensitive detection of pathogens, developed through the strategic integration of heterogeneous interface engineering and enzyme-powered molecular machines. The platform is built on a Ni-MOF-on-Co-MOF heterostru... |
41618833 | Dynamic Chain Exchange of Amphiphilic Alternating/Random Copolymer Micelles Promoted by Structural Uniformity and Flexibility. | Amphiphilic alternating and random copolymers bearing hydrophilic and hydrophobic side chains intramolecularly fold or intermolecularly assemble into size-controlled unimer or multichain micelles in water. The random copolymer micelles are known to dynamically induce the exchange of the polymer chains, whereas effects ... |
41618816 | Additives for Aluminum-Air Batteries: A Review. | The growing demand for efficient energy storage systems directs substantial research attention toward aluminum-air batteries, primarily due to their low cost and the abundant availability of aluminum. Among the various strategies aimed at enhancing their performance, the incorporation of electrolyte additives emerges a... |
41618818 | High-Rate and Selective Conversion of Low-Concentration Carbon Dioxide to Carbon Monoxide Using a Carbon Nanotube-Supported Molecular Electrocatalyst. | Electrocatalytic CO<sub>2</sub> reduction reaction (e-CO<sub>2</sub>RR), powered by renewable electricity, is a compelling strategy to valorize CO<sub>2</sub> into valuable chemicals and fuels. Herein, we report on MWCNT|CuPc-CoPc-modified gas-diffusion electrodes (GDEs) featuring molecular-level dispersion of cobalt p... |
41618796 | f-Block Element-Based MOF Thin Films: A Platform for Luminescence, Sensing, and Energy Applications. | f-Block element-based metal-organic framework (f-MOF) thin films, incorporating lanthanides and actinides, have emerged as a promising class of materials due to their unique properties and potential in sensing, luminescence, and energy-related applications. While MOF powders have been widely explored, many advanced app... |
41618788 | A Chemically Robust 3D Interpenetrated MOF Toward One-Step Methane Purification Along with Six Other Multipurpose Gas Separations. | The development of multipurpose adsorbents for highly efficient separation of various gas mixtures is of great importance; this task becomes highly challenging when the guest constituents have almost similar physicochemical properties. Although many adsorbents have been developed so far targeting flue and biogas separa... |
41618376 | Advanced imaging strategies in cardiac organoids: bridging the gap between structural complexity and functional analysis. | Cardiac organoids have emerged as pivotal models for cardiovascular disease research and drug development due to their ability to recapitulate the in vivo cardiac microenvironment, structure, and function. Imaging technologies are core tools for deciphering their three-dimensional (3D) complexity. This review outlines ... |
41617927 | A bibliometric analysis of global landscape and emerging frontiers of nanogels from 2000 to 2024. | Nanogels are hydrogels embedded with nanoparticles. They have been increasingly applied in drug delivery, biomedical engineering and environmental remediation. At present, no bibliometric study has provided a comprehensive analysis of nanogels. This study aims to summarize the current development and future trends of n... |
41983061 | Circulating extracellular vesicle DNA (EV-DNA) and cell-free DNA in ovarian cancer: pathological relevance and diagnostic applications. | Ovarian cancer is one of the leading causes of gynecologic cancer-related mortality in women. However, a significant proportion of ovarian cancer cases are only detected at an advanced stage (III or IV) and are complicated to treat because of metastasis to the peritoneum. This challenge is compounded by vague symptoms ... |
41909244 | Polymorphism in Self-Assembly of Short Peptoid Sequences. | Due to various applications enabled by diverse morphologies of self-assembled sequence-defined polymers, controlling the self-assembly of synthetic peptidomimetics into designed morphologies has emerged as a promising route for the development of bioinspired functional materials. Herein, we report morphological control... |
41884285 | Recent Advances in Glimepiride Solubility Improvement: A Focus on Formulation Technologies - A Narrative Review. | Glimepiride, a second-generation sulfonylurea used in the management of type 2 diabetes mellitus, is classified as a Biopharmaceutics Classification System (BCS) Class II drug. Its severely limited aqueous solubility (<0.004 mg/mL at pH <7) leads to erratic and insufficient oral bioavailability, preventing consistent a... |
41878133 | Research Progress on Nano-Drug Delivery Systems for Photothermal Cancer Therapy. | Cancer remains one of the most formidable challenges in modern medicine. To mitigate the systemic toxicity associated with conventional therapies such as radiotherapy and chemotherapy, photothermal therapy (PTT) has emerged as a highly promising adjuvant modality. The efficacy of PTT hinges on photothermal agents (PTAs... |
41878127 | Strategies, Challenges and Application Prospects for Exosome Engineering Modifications in Tumor Targeted Therapeutics. | Nanodrugs have significantly revolutionized tumor therapy. Nevertheless, conventional nanodrug delivery systems suffer from a critical limitation: only ~0.7% of administered nanoparticles effectively accumulate in solid tumors, severely restricting clinical therapeutic efficacy. In recent years, exosomes-natural extrac... |
41877902 | From Antibiotic Resistance to Bacterial Vaccines: A New Approach to Controlling Resistant Bacterial Infections. | Antimicrobial resistance (AMR) is one of the major threats to global health, with a complex and diverse underlying mechanism. Vaccines reduce the dependence on antimicrobial agents by preventing and treating bacterial and viral infections, as well as secondary infections caused by both, thereby lowering the risk of AMR... |
41877764 | Safety and Efficacy of Therapeutic Plasma Exchange in Pediatric Non-Neurological Diseases. | <h4>Introduction</h4>Therapeutic plasma exchange (TPE) is a recognized treatment in pediatric immune-mediated and toxicological disorders, though evidence remains limited. This study assesses the safety and efficacy of TPE in children with non-neurological diseases treated at a tertiary hospital over 27 years. We focus... |
41858945 | Self-Cleaning Mechano-Bactericidal Surfaces by Metal-Organic Framework Embedded Polycaprolactone Composites. | Mechano-bactericidal (MB) surfaces mitigate the formation of bacterial biofilm through physical interactions without the use of antibiotics. One challenge of MB surfaces is that unremoved dead bacteria and other debris on MB surfaces could impede contact between bacteria and surface nanostructures, thus reducing their ... |
41809851 | Designing a Vaccine for the Monkeypox Virus Using Immunoinformatics and Structural Tools. | <h4>Background</h4>Monkeypox virus (MPXV) causes mpox, and vaccination is the most effective method of prevention. This project utilized immunoinformatics tools to design a multiepitope subunit vaccine against Mpox.<h4>Materials and methods</h4>Seven MPXV antigens (B18R, B21R, D2L, E8L, N3R, I1L, and N2R) were selected... |
41800258 | Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer. | Triple-negative breast cancer (TNBC) and epithelial ovarian cancer (EOC) pose notable threats to the health of women. Given the poor prognosis associated with TNBC and EOC, new therapeutic agents must be explored urgently. Here, we identified triptonide (TN), a natural compound derived from the traditional Chinese herb... |
41797966 | Cationic nanoparticles-enabled mouthwash combats precancerous oral mucosal inflammation. | During the development of oral squamous cell carcinoma (OSCC), multiple danger signals can initiate chronic oral mucosal inflammation, which then gives rise to precancerous and cancerous lesions. Modulation of immune homeostasis is essential to intercept inflammation-driven OSCC. In this study, we aimed to identify key... |
41755853 | Temperature‑, Concentration‑, and Solvent-Dependent <i>M</i>/<i>P</i> Helicity Switching of Double-Helical Monometallofoldamers with Inversion of Circularly Polarized Luminescence. | Fluorescent double-helical monometallofoldamers [Ag-(<b>1</b>)<sub>2</sub>]-[PF<sub>6</sub>] were constructed by the mononuclear complexation of two bipyridine strands <b>1</b> featuring two L-shaped dibenzopyrrolo-[1,2-<i>a</i>]-[1,8]-naphthyridine units at both ends with a Ag-(I) cation. These monometallofoldamers ex... |
41745236 | Novel Metabolites of <i>Xylaria thienhirunae</i> SWUF17-44.1 with Biological Activities and Molecular Docking Analysis. | The extract of <i>Xylaria thienhirunae</i> SWUF17-44.1 displayed broad-spectrum antimicrobial activity, with higher potency against Gram-positive bacteria than Gram-negative strains. Minimum inhibitory concentration (MIC) values were as low as 0.63 µg/µL for <i>Staphylococcus aureus</i> and 1.25 µg/µL for <i>Bacillus s... |
41744703 | Electrochemical Sensors as a Tool for Taste Perception in Pharmaceutical Products: Advances and Perspectives. | Taste masking in pharmaceutical products is a complex and subjective process that requires reliable evaluation methods. This review focuses on the electronic tongue (e-tongue), an emerging sensor-based technology designed to mimic human taste perception without the need for human panels. E-tongue systems provide object... |
41726649 | High-Load Borage Oil Nanoemulsion Development via Polyol-Free D‑Phase Emulsification. | This study presents the development of borage oil nanoemulsions using the D-phase emulsification (DPE) method, notably excluding alkyl polyols. Utilizing polysorbate 80 as the surfactant, the method achieves high oil concentrations (up to 50% w/w) with minimal surfactant use, obviating the need for hydrophilic-lipophil... |
41716341 | Injectable Zn<sup>2+</sup>-Driven carrier-free hydrogel <i>via</i> self-assembly of natural small molecules for liver fibrosis therapy through concurrent autophagy activation and ferroptosis inhibition. | Activation of autophagy represents a critical pathway for eliminating activated hepatic stellate cells (HSCs). However, excessive autophagy induction may trigger ferroptosis, thereby aggravating liver damage. This study proposes synergistic regulation of HSC autophagy and ferroptosis as a novel strategy against liver f... |
41697878 | Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices. | Microneedle-based technology has revolutionized the field of skin and transdermal delivery research and is considered nowadays as the most straightforward approach to administering drugs through the skin. Microneedle Array Patches (MAPs) success is mainly due to their ability to nullify the skin barrier function that o... |
41696523 | Synthesis, characterization and surface properties of an organosilicon surfactant. | In order to explore alternative substances for traditional fluorocarbon surfactants while maintaining high surface activity, this study successfully designed and synthesized an organosilicon surfactant (SiCH) containing a hydroxyl quaternary ammonium salt. Its molecular structure was confirmed by Fourier transform infr... |
41696327 | ZnCo<sub>2</sub>O<sub>4</sub>‑Based Nanoparticle Sensor for 1‑Pentanol Detection. | When microbial volatile organic compounds (MVOCs) interact with humans, they can be harmful to health, causing irritation and discomfort. Additionally, they act as biomarkers for diseases. Despite the significance of this topic, there are still few detection tests available. This work explores the sensitive detection o... |
41696183 | Analysis of salt resistance conferred by salt overly sensitive 3 protein from mulberry (<i>Morus notabilis</i>). | <h4>Introduction</h4>Soil salinization severely threatens crop productivity and agricultural sustainability. Mulberry (<i>Morus notabilis</i>) is an economically important woody crop, but the molecular mechanisms of its salt tolerance remain unclear. The conserved Salt Overly Sensitive 3 (<i>SOS3</i>) gene regulates io... |
41695486 | Sono-piezoelectric cues regulate neuroinflammatory reflex-arc-mediated α7nAChR-P2RX7 axis to dampen osteoarthritis-correlated pain with osteoarthritis attenuation. | <b>Background:</b> Osteoarthritis (OA) characterized by progressive cartilage degeneration and chronic pain is hindered by the vicious inflammation-pain cycle. Nonsteroidal anti-inflammatory drugs (NSAIDs) can only alleviate clinical symptoms. Although electrical stimulation of the vagus nerve has achieved some results... |
41695472 | Therapeutic Promise of Mitophagy in Cancer: Advancing from Small-Molecule Regulation to Nanotechnology-Enhanced Targeting Therapy. | Mitophagy, a selective autophagic pathway that clears damaged or dysfunctional mitochondria, has emerged as a promising therapeutic approach. Mitophagy maintains a delicate balance between cell survival and death, while mounting evidence suggests that it predominantly promotes tumor cell survival under stress, particul... |
41695292 | Mesoporous silica nanoparticles--based functional platforms for breast cancer therapy: technological advancements. | Mesoporous silica nanoparticles (MSNs) offer remarkable opportunities for the loading and delivery of drugs and other small molecules due to their large specific surface area, tunable mesoporous pore size, ease of modification, and excellent biocompatibility. The active silica hydroxyl groups (Si-OH) on the surface pro... |
41694604 | Waterborne Random Copolymers as Polymeric Surfactants for Emulsion Polymerization. | Waterborne acrylic polymer dispersions are typically produced via emulsion polymerization by using low molar mass surfactants. While these surfactants ensure dispersion stability, they negatively affect coating properties, such as water resistance, adhesion, haze formation, and barrier performance. A promising alternat... |
41694397 | Neoepitopes at the crossroads of immunometabolism: metabolic remodeling of antigen presentation in type 1 diabetes. | Type 1 diabetes (T1D) is an autoimmune disorder driven by progressive destruction of pancreatic β-cells under conditions of metabolic and oxidative stress. This article examines the intersection of immunometabolism and antigen presentation as a central mechanism in T1D pathogenesis. In β-cells, endoplasmic reticulum (E... |
41694339 | Broad and robust T cell immunity compensates the population immune barrier against antibody-escaping Omicron variants. | <h4>Background</h4>Continuous SARS-CoV-2 Omicron emergence poses challenges to immune protection from the previous infection/vaccination in the population. While neutralizing antibodies serve as a key immune protection indicator, their cross-protective effect against novel variants remains limited. However, T cell immu... |
41694133 | Optimization of mannanase expression in <i>Aspergillus niger</i> for enhanced production of mannan oligosaccharides. | Mannan oligosaccharides (MOS) are high-value prebiotics widely applied in the food, feed, and pharmaceutical industries. Mannanase, as the key rate-limiting enzyme in the biosynthesis of MOS, directly determines MOS yield and production cost based on its expression level. However, current industrial enzyme sources comm... |
41693863 | From virtual screening to animal models: chlorhexidine and indinavir as promising anti-Zika drug candidates. | <h4>Introduction</h4>Zika virus (ZIKV) infection is associated with severe neurological complications, but no clinically approved antiviral therapies exist, leaving management reliant on symptomatic support. The essential NS2B/NS3 protease represents a promising drug target for ZIKV.<h4>Methods</h4>We performed structu... |
41693770 | New pyrimidine derivatives as potential agents against hepatocellular carcinoma: design, synthesis, and <i>in vitro</i> and <i>in vivo</i> biological evaluations. | <h4>Background</h4>Sorafenib is a tyrosine kinase inhibitor (TKI) used to treat hepatocellular carcinoma (HCC), but this drug causes clinically significant toxicities in approximately 50% of patients. Given the high frequency and severity of these side effects, it is necessary to develop new, safer drugs to treat this ... |
41693771 | Development of an LC-MS/MS method for amantadine detection in human plasma using ZIF-8 as adsorbent and pharmacokinetic investigation. | In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative determination of amantadine in human plasma, with the incorporation of an internal standard to improve analytical accuracy. Plasma samples collected from volunteers were processed using ace... |
41685363 | Feasibility of combining JAK1 gene editing via CRISPR-CasRx with EGCG-lactoferrin nanoparticle therapy in a microneedle-based platform for atopic dermatitis. | Atopic dermatitis (AD) is an inflammatory skin disease characterized by a complex pathogenesis. Current clinical treatments exhibit several limitations, including low efficacy and considerable side effects, prompting a growing interest in novel therapeutic strategies. In this study, we developed a microneedle-assisted ... |
41685361 | Bridging traditional Chinese medicine theory with advanced MOFs delivery for synergistic drug-resistant infected-chronic wound therapy. | Chronic wounds infected with multidrug-resistant bacteria pose a significant challenge to global health, as traditional monotherapies often fail to eradicate pathogens and restore the damaged wound microenvironment. Engineering innovative nanocomposites that integrate synergistic therapeutics and controlled release is ... |
41683848 | From Multidimensional Management to Mechanistic Insight: A Review of Interventions for Hyperuricemia. | As a major metabolic abnormality following hyperglycemia, hypertension, and hyperlipidemia, hyperuricemia has emerged as a significant global public health issue. The pathological mechanisms of hyperuricemia are complex; it not only directly triggers gout but is also closely associated with various chronic diseases, su... |
41683833 | Investigations of Diclofenac Sorption on Intact and Modified <i>Chlorella vulgaris</i> Biomass with pH-Switchable Desorption. | The growing interest in sustainable and structurally diverse sorbent materials has intensified the search for effective biosorbents that can complement or replace conventional adsorbents. This work presents the potential use of <i>Chlorella vulgaris</i> dried biomass and its modifications (ultrasound-treated, lipid-ext... |
41683832 | Molecular Dynamics Insights into <i>Cassia tora</i>-Derived Phytochemicals as Dual Insecticidal and Antifungal Agents Against Tomato <i>Tuta absoluta</i> and <i>Alternaria solani</i>. | The pressing need for sustainable, plant-based alternatives is highlighted by the growing resistance of agricultural pests to synthetic pesticides. This study examined the pesticidal potential of phytocompounds from <i>C. tora</i> discovered by GC-MS analysis against important tomato insect (<i>T. absoluta</i>) and fun... |
41683824 | Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations. | Plant polyphenols, particularly flavonoids, are prominent bioactives in preventive/complementary therapeutic strategies. This article analyzes how some polyphenols can mitigate oxidative stress and inflammation. These processes are involved in cardiovascular disease, cancer, neurodegeneration, and metabolic disorders. ... |
41683809 | Emerging Nanomedicine Strategies for Chronic Disease Management Based on Chitosan. | Chronic diseases such as cancer, cardiovascular disorders, neurodegenerative conditions, chronic respiratory diseases, autoimmune disorders, chronic kidney disease, persistent infectious diseases, diabetes, and ocular inflammation remain leading causes of morbidity and mortality worldwide. Their complex pathophysiologi... |
41683464 | Synthesis and Radioprotective Activity of Benzyl Sulfoxide/Sulfone Coumarins Derived from Ex-RAD. | In order to identify promising radioprotector candidates, a series of benzyl sulfoxide/sulfone coumarin derivatives were designed and synthesized based on the reported activity of Ex-Rad. Most of the target compounds demonstrated significant radioprotective effects at concentrations of 40 μmol/L and 20 μmol/L in HUVECs... |
41683461 | Methodologies for Assessing Chemical Toxicity to Aquatic Microorganisms: A Comparative Review. | Aquatic ecological issues have garnered significant attention in recent years, driving the demand for convenient, effective, and systematic assessment methods in environmental risk evaluation. This review provides a comprehensive introduction to methodologies for assessing the toxicity of chemicals toward aquatic micro... |
41683459 | Synthesis and Applications of Novel Low-Dimensional Nanomaterials in Catalysis. | Low-dimensional nanomaterials have attracted substantial interest as promising candidates for heterogeneous catalysis thanks to their high density of exposed active sites and abundant unsaturated coordination atoms [...]. |
41683068 | Molecularly Imprinted Deoxynivalenol Surface Plasmon Resonance Sensor Based on Sulfur-Doped Boron Graphitic Carbon Nitride. | Deoxynivalenol (DEOX), a dangerous mycotoxin, causes serious health problems for humans and animals. Hence, the on-site monitoring of DEOX has begun to be important in the health and food sectors in recent years. In the present study, a molecularly imprinted surface plasmon resonance (SPR) sensor based on sulfur-doped ... |
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