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41683066 | Synergistic Eradication of Drug-Resistant <i>Salmonella enteritidis</i> in Food Matrices Through an Ag-MOF Nanozyme with Multiple Enzyme-like Activities. | In this study, a silver-based metal-organic framework (Ag-MOF) nanozyme was synthesized for the synergistic eradication of drug-resistant <i>Salmonella</i> <i>enteritidis</i> in food matrices. Ag-MOF exhibits multiple enzyme-like activities, namely oxidase (OXD)-, peroxidase (POD)-, and superoxide dismutase (SOD)-like ... |
41683064 | Advancing Bongkrekic Acid Detection: From Conventional Instrumental Analysis to Advanced Biosensing for Cross-Toxin Applications. | Bongkrekic acid (BKA), a highly lethal toxin, has been implicated in frequent poisoning incidents in recent years, posing a serious threat to global food safety and creating an urgent need for rapid and sensitive detection methods. This review provides a systematic analysis of the entire BKA detection technologies, cov... |
41682426 | Conducting Polymers for Electrochemical Sensing: From Materials and Metrology to Intelligent and Sustainable Biointerfaces. | Conducting polymers (CPs) have become cornerstone materials in electrochemical sensors and biosensors due to their mixed ionic-electronic conduction, mechanical softness, and intrinsic biointerface compatibility. This review provides a comprehensive and critical overview of the field, tracing the evolution of CP-based ... |
41682423 | Visual Screening of Genetic Polymorphisms in <i>eae</i> Gene of <i>Escherichia coli</i> O157:H7 with Single-Nucleotide Resolution by ARMS-PCR-Mediated Lateral Flow Strip. | Development of rapid, precise and fieldable detection methods for foodborne pathogens is one of the essential requirements in food safety and public health. In this research, the single-nucleotide polymorphisms (SNPs) in the <i>eae</i> gene of <i>Escherichia coli</i> O157:H7 are well visually identified with the design... |
41682420 | Colorimetric Determination of Peroxides: A New Paper-Based Sensor for Detecting Hexamethylene Triperoxide Diamine (HMTD). | Homemade explosives (HMEs) are of increasing interest to security forces worldwide due to their widespread utilization by terrorists. Their synthesis is relatively straightforward, requiring only a few readily available chemical compounds. Among the most popular HMEs are organic peroxides, specifically triacetone tripe... |
41682084 | Polymeric Membrane-Based Systems in Transdermal Drug Delivery. | Controlled drug delivery systems (CDDSs) are increasingly attracting interest from the scientific community in order to achieve highly precise, customized, and efficient therapeutic treatment of various diseases. The challenge is to develop highly innovative devices and appropriate administration methods in order to re... |
41682082 | Hyperbranched Polymer Dendrimers Embedded in Electrospun Nanofibers for Safe and Sustainable Antibacterial Filtration Materials. | The global crisis concerning multidrug-resistant microorganisms necessitates the development of innovative antimicrobial strategies that avoid conventional antibiotics and overcome the toxicity and environmental persistence associated with traditional metal-based biocides. This work aims to develop safe and sustainable... |
41681941 | PD-L1/<i>CD274</i> and miR-155<i>/MIR155HG</i> Genetic Variants as Prognostic and Risk Biomarkers in Diffuse Large B-Cell Lymphoma. | <b>Background/Objectives</b>: Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous malignancy, for which predicting clinical outcomes remains challenging. Although immune-checkpoint pathways are known to influence tumor biology, the impact of their germline variants on DLBCL susceptibility and progn... |
41677539 | Research Progress of Porous Radiative Cooling Films Based on Phase Separation Method. | In recent years, against the backdrop of increasingly prominent global climate change and environmental issues, high-efficiency cooling technologies and energy-saving materials have become key research focuses. Radiative cooling, which reflects sunlight and emits thermal radiation into outer space, enables passive cool... |
41677540 | Concentrated Colloidal Dispersion of Nickelladithiolene Coordination Nanosheet Realized by an Alkylated Modulator. | Nickelladithiolene nanosheet, Ni<sub>3</sub>BHT, is a two-dimensional material composed of nickel ions and benzenehexathiol (BHT). Ni<sub>3</sub>BHT has attracted considerable attention owing to its electrical conductivity. Although conventional Ni<sub>3</sub>BHT is obtained as a solid film or powder, recent studies ha... |
41674557 | Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics. | The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling highly precise disease diagnosis and targeted therapy. AI-driven methodologies, including machine learning and deep learning, facilitate the rapid analysis of complex bio... |
41657951 | Integrated cryopreservation-thawing-transplantation platform for neural stem cell-based spinal cord injury repair. | Spinal cord injury (SCI) repair lacks clinically validated restorative therapies. Transplantation of exogenous neural stem cells (NSCs) offers significant potential for therapeutic applications; however, challenges remain, including substantial cell loss, uncontrolled differentiation, and limited tissue integration wit... |
41650856 | Green ultrasonic engineering of hierarchical microphase structures and enhanced properties in chitosan-silk blends across molecular weight ranges. | Ultrasound processing offers a sustainable and non-chemical strategy for controlling molecular organization in soft materials. In this work, we show that ultrasonication can reorganize chitosan-silk blends into ordered microphase architectures similar to classical AB block copolymers without any chemical synthesis prov... |
41635473 | Protective effect of new histone deacetylase 6 inhibitors in a cisplatin-induced peripheral neurotoxicity murine model. | <h4>Introduction</h4>Histone deacetylase 6 (HDAC6) inhibitors have shown effectiveness in preclinical models of chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of various antineoplastic drugs, with no available preventive or therapeutic treatments. This study presents in vivo results for ITF6464... |
41633145 | Aggregation-induced emission coupled with dual quenching factor induced "on-off-on" electrochemiluminescence sensor for sensitive detection of malathion. | The multi-signal conversion "on-off-on" mode has attracted considerable attention due to its high sensitivity. We developed a novel "on-off-on" electrochemiluminescence (ECL) sensor, in which an Ag-MOF with coordination-triggered aggregation-induced emission (AIE) served as the emitter and polydopamine-modified Fe-MOF ... |
41626190 | Traceless linkers used for reversible protein-polymer conjugations. | Proteins and peptides are an important class of biomolecules employed as therapeutics. Polymer conjugation to therapeutic proteins and peptides can improve their stability and circulation time, as well as reduce aggregation compared to the native biomolecule. However, the steric effect of a large polymer has the potent... |
41626186 | Mechanistic insights and catalyst design for the selective hydrogenolysis of cellulose to C<sub>2</sub>-C<sub>3</sub> alcohols. | Catalytic hydrogenolysis of cellulose into low-carbon alcohols offers a promising route toward sustainable chemical manufacture and carbon-neutral energy systems. Recent advances in aqueous-phase catalysis have progressively clarified the reaction network encompassing cellulose depolymerization, glucose isomerization, ... |
41624945 | Synthesis, spectroscopic characterization, and DFT-assisted molecular docking analysis of novel 1,3,4-oxadiazole-1,2,3-triazole hybrids with antimicrobial and cytotoxicity potential. | A novel series of heterocyclic derivatives (10a-i, 11a-d) was successfully synthesized and evaluated through a synergistic combination of density functional theory (DFT), molecular docking, and <i>in vitro</i> biological assays to explore their potential as multifunctional therapeutic agents. Theoretical investigations... |
41624940 | A synergistic dual-mode biosensor for methotrexate detection leveraging FRET and Ag NP-based UV absorption. | A novel dual-mode sensing platform (DMSP) integrating fluorescence and ultraviolet (UV) detection was developed for the sensitive and accurate quantification of methotrexate (MTX). This approach combines a FRET-based fluorescent "turn-on" mechanism, employing FAM as the fluorophore and BHQ as the quencher, with a UV ab... |
41624941 | A new hybrid bismuth chloride semiconductor (C<sub>5</sub>H<sub>7</sub>BrN<sub>3</sub>)<sub>6</sub>(BiCl<sub>5</sub>)<sub>3</sub>: powder XRD, optical properties, and DFT investigation. | In this work, we report the synthesis and characterization of the new hybrid inorganic-organic compound (C<sub>5</sub>H<sub>7</sub>BrN<sub>3</sub>)<sub>6</sub>(BiCl<sub>5</sub>)<sub>3</sub>, which crystallizes in the triclinic space group <i>P̄</i>1. The crystal structure, determined from X-ray powder diffraction, reve... |
41624178 | Biomimetic Nanotechnology Overcoming the Blood-Testis Barrier for Testicular Protection in Chemotherapy. | Cancer patients exposed to chemotherapeutic drugs and whole-body radiation can result in testicular injury and germ cell loss. One of the mechanisms is that these drugs lead to the accumulation of reactive oxygen species (ROS) in the testes, which has been documented to cause testicular damage. Therefore, this highligh... |
41621547 | HER2-dependent paraptosis and ferroptosis induction by cannabidiol in breast cancer cells. | HER2 (human epidermal growth factor receptor 2) is a well-established oncogenic driver and therapeutic target in breast cancer. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, has demonstrated anticancer potential, yet its mechanisms of action in HER2-positive breast cancer remain insufficiently characterized. ... |
41621512 | Recent advances in chitosan-based mixed matrix membranes for efficient wastewater treatment. | Chitosan-based membranes are considered promising materials for wastewater treatment owing to their biodegradability, functional groups, and film-forming properties. However, pristine chitosan membranes often lack sufficient mechanical strength, chemical stability, and selectivity for practical applications. This revie... |
41621495 | 3D printed intrauterine device development containing dual anticancer drugs for the treatment of uterine cancer. | Uterine cancer is a major global health problem and treatment frequently includes invasive surgery that severely compromises fertility. Current systemic chemotherapeutic drugs, such as paclitaxel (PCX) and carboplatin (CBP), lack an established standard protocol and their efficacy is limited. This study focuses on the ... |
41619738 | Chemical inhibition of a bacterial immune system. | The rise of antibiotic resistance motivates a revived interest in phage therapy. However, bacteria possess dozens of anti-phage immune systems that confer resistance to therapeutic phages. Chemical inhibitors of these anti-phage immune systems could be employed as adjuvants to overcome resistance in phage-based therapi... |
41619517 | Influence of anaerobic digestate and wood ash on phenanthrene bioaccessibility and mineralisation in soil. | The environmental persistence and ecotoxicity of polycyclic aromatic hydrocarbons (PAHs) have stimulated considerable interest in understanding their bioaccessibility and biodegradation in soils. Factors such as contact time, organic amendments, and microbial inoculation can influence these processes. This study examin... |
41619447 | Comparability of Interstitial and Capillary Blood Glucose Values: A Cross-Sectional Study of Samples from Patients with Multiple Organ Failure. | <h4>Purpose</h4>Several studies have evaluated the use of interstitial flash glucose (IFG) monitors in critically ill patients. IFG offers potential advantages over capillary blood glucose (CBG) measurements. This study examined the agreement between IFG and CBG values in patients with multiple organ failure (MOF) who ... |
41619354 | Innate immune priming by n-dodecyl-β-D-maltoside in murine models of bacterial and viral infection. | <h4>Background</h4>The COVID-19 pandemic underscored how hospital-acquired co-infections with antimicrobial resistance (AMR) bacteria and respiratory viruses can drive high mortality in critically ill patients. Despite antimicrobial stewardship and vaccines, effective prophylactic solutions remain lacking, highlighting... |
41618552 | Rhodium-Catalyzed Enantioselective Synthesis of Planar-Chiral Macrocycles via De Novo Isoquinoline Formation. | De novo formation of the aromatic ring is an attractive strategy for atroposelective synthesis, but its application to planar-chiral macrocycles remains challenging. Herein, we report a rhodium-catalyzed enantioselective synthesis of planar-chiral macrocycles via de novo isoquinoline construction. This method is charac... |
41618544 | Molecular Design of Highly Efficient Heavy-Atom-Free Near-Infrared Cyanine Photosensitizers for Fluorescence Image-Guided Photodynamic Therapy of Solid Tumors. | Recent advancements in photodynamic therapy (PDT) have highlighted its potential as a non-invasive cancer treatment. However, to fully realize the clinical potential of PDT, the development of innovative photosensitizers is essential. In this study, efficient heavy-atom-free PSs (IR820-1-3) activated by 808 nm light ir... |
41618536 | Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle. | The pyridine contracted to form the pyrrole ring. This transformation belongs to a unique class of reactions with the fundamental characteristic of the cleavage of the aromatic structure. By investigating the unusual coordination chemistry of N-confused pyriporphyrin with silver and gold ions, we observed this process ... |
41618534 | Supramolecularly Engineered Flexible Zinc-Iodine Batteries for Wearable Electronics. | Flexible aqueous zinc-iodine batteries (AZIBs) have emerged as promising candidates for the power source in wearable electronics, owing to their intrinsic safety and cost-effectiveness. However, electrochemical and mechanical interface instability between zinc anodes and electrolytes under deformation prevent the relia... |
41618467 | Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders. | Neurodegenerative disorders involve the gradual breakdown of neurons, leading to problems with thinking, movement, and mental health. More evidence is emerging about the important roles of non-coding RNAs (ncRNAs). CircRNAs are a type of ncRNA formed through back-splicing and are widely present in the mammalian brain. ... |
41618417 | Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis. | <h4>Background</h4>Inducible nitric oxide synthase (iNOS) is a key driver of aberrant angiogenesis in inflammatory conditions and cancer, making it an attractive therapeutic target. Nevertheless, its function can be affected by the complex immune responses and tumor microenvironment (TME). Hence, combinatorial treatmen... |
41618412 | Mendelian randomization study: investigating the causal impact of Covid-19 on adverse pregnancy outcomes. | <h4>Background</h4>Due to limitations in observational studies, the link between COVID-19 and adverse pregnancy outcomes (APOs) remains inconclusive. This study uses two-sample Mendelian randomization (MR) analyses to assess COVID-19's causal effects on APO traits.<h4>Methods</h4>We applied inverse variance weighting (... |
41618421 | Novel and sustainable microfabricated Cu ion selective sensor doped with ionophore and supported with docking study for determination of vonoprazan fumarate in tablet dosage form. | In the field of drug analysis, there is a growing emphasis on developing techniques that are environmentally friendly, cost-effective, and efficient. To align with the principles of green analytical chemistry and to support the advancement of portable and handheld devices, an innovative microfabricated ion selective el... |
41618406 | Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration. | Solid tumors pose a spatial "delivery-at-depth" bottleneck: therapeutics that reach tumors often remain sequestered near vessels and fail to distribute uniformly into tumor cores. This limitation arises from heterogeneous perfusion, elevated interstitial fluid pressure, and dense extracellular matrix, which together re... |
41618393 | Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition. | Endothelial cells (ECs) of endothelial-to-mesenchymal transition (EndMT) are drivers of cardiac fibrosis. BRD4 has recently been identified as an epigenetic regulator of EndMT. Proteolysis-targeting chimera (PROTAC) technology has revolutionized targeted protein degradation, offering unprecedented opportunities for BRD... |
41618355 | A newly developed covalent organic framework decorated with chromium for efficient methanol fuel cell. | Covalent Organic Frameworks (COFs) have emerged as a promising class of crystalline porous materials with potential applications in various fields, including catalysis, gas storage, and energy conversion. A novel COF was prepared from the reaction of terephthalaldehyde and tris(2-aminoethyl)amine and characterized usin... |
41618287 | Plant-derived exosomes: an emerging delivery platform for cancer therapy. | Cancer continues to be the second leading cause of death globally. Although medical technologies have advanced significantly, cancer treatment still faces major challenges, such as drug resistance and dynamic alterations in tumor microenvironment (TME). Plant-derived exosomes (PDEs) are promising to serve as next-gener... |
41617822 | Surface functionalization strategies for polydiacetylene-based colorimetric sensors. | Polydiacetylene (PDA)-based colorimetric sensors offer a promising platform for rapid and visual detection, through a chromatic transition from blue to red. However, their broader applications are hindered by challenges in sensitivity, selectivity, and stability. This review comprehensively overviews functionalization ... |
41617767 | Insights into the seismogenesis and tectonic implications of an isolated intraplate earthquake (M4.0) on February 17, 2025, in Delhi. | On February 17, 2025, a magnitude 4.0 earthquake occurred near Jheel Park in South Delhi, approximately 6 km from the epicenter of the November 25, 2007, M4.6 event, one of the most significant regional earthquakes in recent decades. The tremor was widely felt across Delhi and adjoining regions, accompanied by a distin... |
41617717 | Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation. | Stem cell differentiation dynamically remodels and stiffens the extracellular matrix (ECM), generating stage-specific biomechanical cues that guide tissue development. However, conventional biomaterials, designed to mimic mature ECM stiffness, neglect its spatiotemporal heterogeneity due to their static, non-evolvable ... |
41617699 | TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience. | OSCA/TMEM63 mechanosensitive ion channels play critical physiological roles in plants and animals. These channels bear structural homology to the dual functional TMEM16 family, and OSCA1.2 was recently shown to form a lipid-lined ion conduction pathway in the open state. This raised the question of whether members of t... |
41617705 | Dynamic stretching beyond electron transfer in a homointerpenetrated metal‒organic framework for enhanced Fenton-like reactions. | While extensive efforts have been devoted to enhancing electron transfer efficiency through metal valence cycling in heterogeneous Fenton-like reactions, the potential catalytic improvement induced by dynamic structural stretching remain unexplored. Here, we introduce a homointerpenetrated Fe-based metal‒organic framew... |
41617680 | A radiolabeled dendrimer non-invasively identifies and tracks innate immune cell activation in a mouse model of experimental autoimmune encephalomyelitis. | Multiple sclerosis (MS) is a chronic neurodegenerative disease driven by infiltration of activated innate immune cells into the central nervous system (CNS). Current imaging approaches for diagnosing and monitoring disease progression rely on structural lesions and cannot directly assess innate immune activity. Here, w... |
41617674 | Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis. | Cells actively sense and transduce microenvironmental mechanical inputs into chemical signals via cytoskeletal rearrangements. During these mechanosensation and mechanotransduction processes, the role of the actin cytoskeleton is well-understood, whereas the role of the tubulin cytoskeleton remains largely elusive. Her... |
41617210 | Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues. | Molecular glues, compounds that bind cooperatively at protein-protein interfaces (PPIs), are revolutionizing chemical biology and drug discovery, allowing the modulation of traditional "undruggable" targets. Here, we focus on a native regulatory PPI between the scaffolding protein 14-3-3 and C-RAF, a key component of t... |
41617188 | ArtiDock: Accurate Machine Learning Approach to Protein-Ligand Docking Optimized for High-Throughput Virtual Screening. | Classical protein-ligand docking has been a cornerstone technique in computational drug discovery for decades but has reached an accuracy and performance plateau. Recently introduced Machine Learning (ML)-based docking methods offer a promising paradigm shift, but their practical adoption is hampered by accuracy-to-spe... |
41617143 | Zoledronic acid/cisplatin-loaded cucurbit[7]uril-modified upconversion nanoformulations drive tumor-associated macrophage polarization and potentiate the efficacy of cancer immunotherapy. | Tumor-associated macrophages (TAMs) play a pivotal role in establishing a tumor immunosuppressive microenvironment (TIME) by inducing a phenotypic shift in macrophage from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. This polarization facilitates tumor growth, progression, metastasis, immune evasion, ... |
41616220 | Ambient Pressure Fabrication of Cu<sub><i>x</i></sub>Zn<sub>1-<i>x</i></sub>(BDC)<sub>2</sub>DABCO Thin Films Through Spin-Coating and Their Temperature-Dependent Structural Development. | Metal-organic frameworks (MOFs) have garnered widespread attention due to their inherent tunability and consequent applications for a variety of technologies. Spin-coating is a fast and cost-effective method for new materials discovery, which yields less chemical waste than traditional solvothermal, dip-coating, or oth... |
41616122 | Targeting the GPX4-FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis-Associated Lung Injury. | Sepsis-associated lung injury (SALI) remains a critical clinical challenge, partly driven by ferroptosis-induced endothelial dysfunction. The pathological interaction between FUN14 domain-containing protein 1 (FUNDC1) and glutathione peroxidase 4 (GPX4) promotes ferroptosis and disrupts mitophagic flux. Magnesium litho... |
41616107 | NuSAP Safeguards Centriole Integrity to Mediate CEP57-CEP152 Torus Recruitment for Proper Engagement. | Precise centrosome regulation is crucial for faithful cell division, yet how microtubule-associated proteins (MAPs) contribute to centrosome integrity remains poorly understood. Here, we uncover a novel localization of NuSAP-a RanGTP-regulated MAP-on centrioles using super-resolution microscopy. NuSAP depletion disrupt... |
41616103 | Clickable Microgel Inks Enable Spatioselective, Multi-Stimuli Programmable Assembly of Materials. | Life-like materials that can dynamically morph their shape/texture, inspired by living organisms such as cephalopods are sought after for soft robotics and camouflage applications. Achieving such functions demands multimaterials with spatially programmed responses, yet their creation remains challenging. The existing a... |
41616095 | Ultrasoft Yet Tough Multifunctional Organohydrogels Enabled by Molecular Chain Lubrication Strategy for Self-Powered Wearable Electronics. | Flexible triboelectric nanogenerators (TENGs) underscore the promise of skin‑inspired hydrogels as intelligent materials for wearable electronics. However, overcoming the intrinsic trade‑off between stiffness and toughness while integrating multifunctionality into the hydrogels remains a great challenge. Here, we propo... |
41616090 | A Covalent 3D CNT@rGO Nano-Hybrid for High-Efficiency Conductivity in Lithium-Ion Batteries. | The limitations of conventional conductive agents in lithium-ion batteries, such as carbon black and graphite flakes, have driven the search for high-performance alternatives. Carbon nanotubes (CNTs) and graphene offer exceptional conductivity and lower dosage requirements, but face challenges related to high costs and... |
41616043 | Mesostructure-Dependent Capacitive Performance in Two-Dimensional Conductive Metal-Organic Framework Films: Effects of Crystallite Orientation and Aggregation Morphology. | Performance of two-dimensional conductive metal-organic frameworks (MOFs) in supercapacitor applications relies not only on their intrinsic structural properties but also on their mesostructures related to the size, shape, orientation, and aggregation morphology of crystallites assembled on a current collector. Neverth... |
41616037 | Selective Deuteration of Neopentyl Glycol and Its Effect on the Plastic Crystal Transformation. | Transitions between rotationally ordered and disordered states in globular small molecules are associated with large entropy changes and thus hold promise as solid-state barocaloric refrigerants. However, the relationships between elements of the molecular structure and the corresponding thermodynamic properties of the... |
41615966 | In vitro assessment of antibacterial and biocompatibility properties of a poly-ε-lysine and hyaluronic acid contact-killing coating to prevent prosthetic joint infection. | Prosthetic joint infection (PJI) is a major adverse outcome following total hip and knee arthroplasties. With the rise of antimicrobial resistance, there is a risk of therapeutic insufficiency in treating PJI. This study determined the potential of a poly-ε-lysine and hyaluronic acid (PEL-10/HA144-1) contact-killing co... |
41615889 | Monitoring the Switching from Base-on to Base-off Forms of Vitamin B<sub>12</sub> by Natural and Magnetic Circular Dichroism Spectroscopies. | This work demonstrates that an approach which makes use of magnetic circular dichroism (MCD) together with electronic circular dichroism (ECD) brings one to a rapid, sensitive, nondestructive, and inexpensive determination of the electronic structure of diamagnetic, chiral, and flexible molecular systems. The subject o... |
41615852 | It is Separation, Not Contact: Electrification at Water-Hydrophobe Interfaces during Wetting-Dewetting Cycles. | When water contacts hydrophobic materials─such as air, hydrocarbons, or fluorocarbons-the interface acquires charge, yet how dynamic wetting-dewetting governs this electrification remains largely unexplored. Here, using controlled pipetting experiments with hydrophobic capillaries, we show that electrification at water... |
41615768 | Discovery of Diverse Esterified <i>seco</i>-Polycyclic Polyprenylated Acylphloroglucinols from Two Species of <i>Hypericum</i> Linn. and Their Lipid-Lowering Effect. | Hyperesternoids A-K (<b>1-11</b>, respectively), 11 unique esterified <i>seco</i>-PPAPs (<i>seco</i>-polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic (<b>1-3</b>), 5/7/6 tricyclic (<b>4-6</b>), and 5/6/6 tricyclic (<b>7-11</b>), were isolated from two plants of the <i>Hy... |
41615744 | The role of fluctuations in the nucleation process. | The emergence upon cooling of an ordered solid phase from a disordered liquid is a remarkable example of self-assembly, which has also major practical relevance. Here, we use a recently developed committor-based enhanced sampling method to explore the crystallization transition in a Lennard-Jones fluid, using variation... |
41615746 | All-visible-light-responsive porous aromatic frameworks manipulate CO<sub>2</sub> uptake by reversible bulk isomerization of azobenzene pendants. | Embedding light-responsive small molecules in a porous solid is a promising strategy to achieve dynamic control over material properties. Powering these systems with low-energy photons is essential for their future applications, since visible light, compared to UV light, is less damaging and offers more selective isome... |
41615745 | Fe metal-organic framework-derived heterojunction for metabolic diagnosis of thymic epithelial tumor. | Thymic epithelial tumors (TETs), rare yet clinically significant malignancies, face diagnostic challenges due to their occult presentation and lack of noninvasive risk-stratification tools, leading to systemic overtreatment and poor prognoses for high-risk subtypes. To address this unmet need, we developed a Fe<sub>3</... |
41615415 | MOF-Driven Direct Oxidative Electrocatalysis of Urea. | Achieving high efficiency, stability, and mechanistic clarity in urea electro-oxidation is vital for advancing sustainable energy and environmental remediation. Here, we present a rationally engineered class of TiO<sub>2</sub>-supported Ni-Cu bimetallic metal-organic frameworks (MOFs) exhibiting catalytic activity with... |
41615417 | A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells. | The language with which the neurons of the cerebellum encode information appears distinct from the rest of the brain. For example, although in the cerebral cortex and the superior colliculus neurons display a retinotopic map that indicates the location of the visual event with respect to the fovea, and in the brainstem... |
41615270 | HHV-8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions. | The incidence of HHV-8/KSHV-associated diseases (KADs) among solid organ transplant (SOT) recipients has shown a relative increase, likely reflecting the growing population of long-term SOT survivors and heightened recognition and reporting due to greater clinician awareness. The real impact of HHV-8/KSHV in the SOT se... |
41615274 | BODIPY-Doped Nanocarrier Engineering (BONE) Improves Bone Marrow mRNA Delivery by NIR-II Bioimaging Guided Screening. | Efficient delivery of mRNA to the bone marrow is crucial for maintaining immune homeostasis and understanding the pathogenesis of numerous disorders. However, achieving effective delivery remains challenging due to the low blood perfusion of bone tissue and the restrictive blood-bone marrow barrier. Conventional strate... |
41615248 | Thermo-Chemically Modified Silk Scaffolds Reveal Niche-Driven Regulation of Hematopoiesis and Fibrosis. | Recreating the human bone marrow microenvironment in vitro remains a critical challenge in advancing our understanding of hematopoiesis and its disruption in disease. Here, we present a fully tunable bone marrow model based on silk fibroin scaffolds engineered through thermo-chemical processing to replicate the mechani... |
41615238 | Stable Coacervate Microdroplets as Robust Microreactors for Enhanced Enzymatic Catalysis. | Membraneless organelles formed through liquid-liquid phase separation (LLPS) regulate cellular functions by creating dynamic compartments that enhance rates of biochemical reactions. Inspired by these natural systems, coacervate microdroplets serve as biomimetic platforms to study LLPS mechanisms and develop functional... |
41615206 | Computational and experimental identification of potential neutralizing peptides derived from human ACE2 against SARS-CoV-2 infection. | The human angiotensin-converting enzyme 2 (hACE2) is the primary receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some human alleles of ACE2 exhibit an improved affinity for the SARS-CoV-2 Spike protein. However, the impact of ACE2 polymorphisms on SARS-CoV-2 infection remains unc... |
41615159 | Ligand binding drives proteolysis of the SmcR master transcription factor and controls quorum sensing-state transitions in <i>Vibrio</i> species. | In <i>Vibrio</i> species, quorum sensing signaling culminates in the production of the master transcription factor SmcR that regulates group behavior genes in a density-dependent manner. Previously, we identified a small-molecule thiophenesulfonamide inhibitor called PTSP [3-phenyl-1-(thiophen-2-ylsulfonyl)-1<i>H</i>-p... |
41615147 | Pentameric M2e influenza vaccine candidate generates strong immunity with limited survival benefit. | We previously demonstrated that native-like oligomers of Influenza A H1N1 M2e, expressed in Expi293F cells, elicit robust immune responses. Building on this foundation, we engineered a recombinant antigen comprising five tandem repeats of the M2e epitope (M2e-5x) fused to the tGCN4 domain, which promotes oligomerizatio... |
41615146 | <i>In vitro</i> activity of gallium-protoporphyrin IX against <i>Leishmania major</i> and <i>Leishmania infantum</i>. | <i>Leishmania</i> spp., the causative agents of leishmaniasis, pose significant global health threats, with visceral leishmaniasis being the most severe and fatal form. The increasing drug resistance in the treatment of leishmaniasis emphasizes the urgent need for novel therapeutic approaches. One promising strategy in... |
41615060 | Electrochemical Sensor Based on Acetylene Black-Modified Two-Dimensional Metal-Organic Framework [Cd<sub>2</sub>(BPDC)<sub>2</sub>(1,4-bis)<sub>2</sub>]<i><sub>n</sub></i>/AB for Efficient Detection of NO<sub>2</sub><sup/>. | Excessive nitrite poses potential threats to human health, making the convenient and accurate detection of nitrite anions (NO<sub>2</sub><sup>-</sup>) critically important for practical applications. Two-dimensional (2D) metal-organic frameworks (MOFs) have attracted attention in the design and application of electroch... |
41614717 | Photoresponsive and Reusable Chiral Metal-Organic Framework Hybrid Nanochannel Membrane for Drug Enantioseparation. | Chiral metal-organic framework (CMOF)-based porous membrane materials have attracted great interest in the enantioseparation community. Despite remarkable progress, it remains a challenge to obtain functional membranes with a tunable enantioselectivity. Herein, we report on a photoresponsive and enantioselective nanopo... |
41614668 | A Functionality-Graded Cathode Electrolyte Interphase Enables Ultra-Long Cycling Stability in Aqueous Zn-Mn Batteries. | The rational design of cathode electrolyte interphases (CEI) is pivotal for enhancing reaction kinetics and stability in zinc-manganese batteries, yet their design principle and formation mechanisms remain unclear. In this work, we introduce an electrolyte additive-driven in situ strategy using trace KH<sub>2</sub>PO<s... |
41614641 | Intelligent Thermo-Self-Limited Magnetothermia with Heat-Triggered TERT Silencing for Precision Synergetic Cancer Therapy. | The combination of hyperthermal therapy and gene therapy (GT) has emerged as a promising strategy for cancer treatment. However, the overheating damage and complex temperature control procedure in hyperthermal therapy, along with the limited precision of GT, greatly compromise the therapeutic effectiveness. In this stu... |
41614634 | Spatial Control Over Tether-Tunable Coordination on Palladium for Divergent Synthesis of Bicyclo[n.1.0]alkanes via Oxidative Cyclopropanation of Enynes. | Bicyclo[n.1.0]alkanes are highly valuable scaffolds in drug discovery and synthetic chemistry. However, their efficient and stereocontrolled construction remains a desirable yet challenging task. Herein, we report a palladium-catalyzed oxidative cyclopropanation of 1,n-enynes using cyclic malonyl peroxides as modular, ... |
41614566 | Adsorption-Induced Surface Magnetism. | We report the emergence of adsorption-induced magnetism from heterohelicene molecules on a nonmagnetic Cu(100) surface. Spin-polarized low-energy electron microscopy measurements reveal spin-dependent electron reflectivity for enantiopure 7,12,17-trioxa[11]helicene (TO[11]H) monolayers, indicating the formation of a sp... |
41614449 | In Situ Ptychographic X-ray Computed Tomography of Fully Hydrated Polyamide Membranes. | Understanding the morphology of membranes under operational conditions is essential for advancing membrane material development for water purification and industrial applications. Traditional characterization methods, such as scanning and transmission electron microscopy, require vacuum environments and sample modifica... |
41614391 | Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation. | Atherosclerosis (AS), a chronic vascular pathology characterized by endothelial dysfunction, arises from the interplay of lipid dysregulation, oxidative stress, and inflammatory activation. Reactive oxygen species (ROS) overproduction triggers Nod‑like receptor protein 3 (NLRP3) inflammasome signaling, exacerbating inf... |
41614401 | Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review). | Circulating tumor cells (CTCs) are shed from the primary tumor into the peripheral bloodstream, where they play crucial roles in tumor metastasis and recurrence. As a cornerstone of liquid biopsy, CTCs hold significant potential for early tumor diagnosis, therapeutic response monitoring, and prognosis. However, the rar... |
41614403 | Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review). | Mitochondria are central to cellular metabolic reprogramming, and their energy metabolism pathways are indispensable for T‑cell activation, proliferation and differentiation. Mitochondrial metabolic reprogramming enhances T‑cell activity and antitumor function. Mitochondrial dynamics, including fusion, fission and tran... |
41614399 | In-Situ Exploration of Phytic Acid-Mediated Supramolecular Self-Assembly and Gelation. | Molecular gels emerge as a promising type of material owing to their high tunability for versatile applications. However, there are still gaps in our mechanistic understanding of the molecular assembly and its consequent physicochemical properties. Additionally, most of the methods for hydrogel characterization require... |
41614275 | Peiminine-Induced Selective Autophagy of AIM2 Inflammasomes Rescues Cerebral Ischemic Injury. | <h4>Background</h4>Inflammasome hyperactivation drives neuroinflammation following cerebral ischemia, yet pharmacological strategies inducing their selective clearance remain largely unexplored. Selective autophagy holds particular promise as a therapeutic strategy by eliminating detrimental substrates while avoiding t... |
41614240 | Introducing Small Rings into Farnesyl Pyrophosphates Paves the Way for the Enzymatic Generation of Unnatural Sesquiterpene Scaffolds. | New sesquiterpene skeletons are accessible when the geminal dimethyl group in farnesyl pyrophosphate (FPP) is exchanged by small strained rings, specifically cyclopropane, cyclobutane, and oxetane. When these new FPP derivatives are exposed to sesquiterpene synthases, the additional chemical reactivity installed in the... |
41612972 | <i><b>Muribaculum intestinale</b></i> <b>negatively impacts glioma growth in mice through the toll-like receptor 2</b>. | Glioblastoma (GBM) is the most common and malignant brain tumor in adult humans. Recent studies have demonstrated a link between the composition of the gut microbiota and glioma progression. Here, we describe that the growth of glioma in mice is inversely correlated with the relative abundance of the anaerobic bacteriu... |
41612956 | Adhesive Photoinitiator Constructs Polymer Jackets on Enzymes: Direct, Release-Free Cytosolic Delivery. | Enzyme therapeutics require both catalytic activity and efficient cytosolic delivery-yet protective encapsulation typically compromises enzymatic function, while achieving cellular uptake without lysosomal degradation remains challenging. We address this with a rationally designed supramolecular adhesive photoinitiator... |
41612934 | Size-Controllable Curcumin-Based Metal-Organic Framework-Integrated Multifunctional Hydrogel for Wound Healing Through Antibacterial and Antioxidant Properties. | Bacterial infection and oxidative stress at wound sites can significantly impede the wound healing process. Curcumin, a versatile and abundant natural product, exhibits broad-spectrum antibacterial and antioxidant properties and is under investigation as a promising wound healing agent. However, its inherent limitation... |
41612007 | Comparative analysis of the nasal effects of two alar cinch suture techniques in LeFort I osteotomy. A retrospective longitudinal study. | <h4>Aim</h4>The purpose of this study was to compare postoperative nasal morphological changes between two intraoral alar cinch suture techniques in patients undergoing Le Fort I osteotomy.<h4>Methods</h4>A retrospective longitudinal study was conducted with patients undergoing Le Fort I osteotomy, and two types of ala... |
41611870 | Inorganic High-Performance Fiber-Based Materials for Electromagnetic Interference Shielding: Fundamentals, Fabrications, and Emerging Applications. | Confronted with increasingly severe challenges of electromagnetic interference (EMI) and electromagnetic radiation pollution in industrial, military, and aerospace applications, the development of novel materials that combine high shielding efficiency with excellent comprehensive performance has become a research hotsp... |
41611721 | Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly. | Binding of the surrogate light chain (SLC) to the heavy chain (HC) of the pre-B cell receptor (preBCR) is an important quality control checkpoint during B cell development as roughly 50% of the rearranged HCs are defective. Unlike the regular light chain (LC), the SLC is a hetero-dimer of VpreB and λ5, both containing ... |
41611720 | Inverse palladocenes. | Metallocene research has influenced the development of organometallic chemistry, and the metal-nonmetal inverted half-sandwich structure (inverse metallocene) was very recently discovered. However, additional instances are required to propose the concept inverse metallocene and it remains uncertain whether metal five-m... |
41611660 | Employing epigenetic protein degradation techniques to block CCL5-mediated photodynamic therapy via a programmed delivery platform. | Despite the significant potential of photodynamic therapy (PDT) in cancer treatment, further refinement is needed to address challenges such as poor tumor-specific accumulation of photosensitizers and the development of therapeutic resistance, which may be regulated by epigenetics. Here, a novel tumor microenvironment-... |
41983051 | Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axis. | <b>Aim:</b> Reactivating the human immunodeficiency virus type 1 (HIV-1) reservoir is one of the key avenues toward a functional cure for acquired immunodeficiency syndrome (AIDS). However, clinically effective and safe latency-reversing agents remain lacking. Exosomes play an important role in regulating latent HIV-1.... |
41907765 | Spontaneous switching in a protein signalling array reveals near-critical cooperativity. | Cooperative interactions within large protein assemblies are crucial for cellular information processing. However, direct observations of cooperative transitions have been limited to compact molecular assemblies. Here, we report <i>in vivo</i> FRET measurements of spontaneous discrete-level transitions in the activity ... |
41884272 | Evaluation of Chitosan-Pimelate Buccal Film Loaded with Duloxetine-Modified Sage Lipid Carriers Nanoformulation for Effective Antidepressant Activity in a Rat Model. | <h4>Introduction</h4>Chitosan-pimelate (CS-Pim) mucoadhesive buccal films were developed to improve the therapeutic efficacy of duloxetine (DLX) using sage oil-based lipid carriers (DLX-SLCs). This buccal nanoplatform addresses DLX's limited oral bioavailability and extensive first-pass metabolism by providing a non-in... |
41878129 | Nanoscale Approaches to Oro-Dental Tissue Engineering: A Review of Strategies, Composites, and Translational Challenges. | Oral health is vital to human well-being. As a result, various conditions in the oral cavity, including exposure to dentin and edentulous states, lead to diverse oral issues and tissue loss. Although conventional treatments are available, they often have limitations in drug delivery and tissue regeneration. For example... |
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