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41878124 | Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation. | Bone defect repair, particularly for critically sized defects, remains a formidable clinical challenge owing to the limitations of conventional bone grafts and single-functional scaffolds. Janus membranes, with their asymmetric structure and capacity for multi-functional integration, offer an innovative "all-in-one" so... |
41809032 | Evolutionarily entrenched odorant receptors for (<i>E</i>)-β-farnesene signaling in Aphidinae aphids. | Alarm pheromones are crucial for the survival of social insects, enabling coordinated escape from predators. Their evolution has co-evolved with the development of olfactory recognition systems, suggesting specific molecular mechanisms underlie this adaptive relationship. We analyzed alarm pheromone compositions across... |
41777972 | Ideal Versus Actual Body Weight for Dosage of Sugammadex in Patients With Body Mass Index Less Than 18.5: A Randomized Controlled Trial. | <h4>Introduction</h4>To date, no study has evaluated the appropriate sugammadex dose in underweight patients. Therefore, we aimed to compare time to recovery from deep neuromuscular block after administration of sugammadex based on either actual or ideal body weight in patients with a body mass index (BMI) of less than... |
41743237 | Sphingolipid-neutralizing molecular therapy reduces psychosine cytotoxicity in Krabbe disease. | The deficiency of β-galactosylceramidase causes a lysosomal leukodystrophy, known as Krabbe disease (KD), resulting in elevated psychosine (PSY) levels, which are highly cytotoxic to myelin-forming cells. 2-hydroxypropyl-α-CD (HPaCD), a cyclic-oligosaccharide containing a lipophilic central cavity and hydrophilic outer... |
41746058 | Harnessing Vaccines in the Treatment of Solid Tumors: Advances, Challenges, and Future Directions. | Immunotherapy has become a cornerstone of cancer treatment in both the early and advanced setting in recent years, leading to the achievement of substantial and durable responses with an excellent safety profile across different tumor types. This demonstrates the high potential of engaging the immune system in the trea... |
41744992 | Smart Composite Hydrogels for Monitoring and Managing Chronic Wounds. | The precise management of chronic wounds poses a global medical challenge, owing to their complex and dynamically shifting pathological microenvironment, coupled with their inherent difficulty in healing. Traditional dressings, which lack capabilities for real-time monitoring and active intervention, fall short of meet... |
41743235 | Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses. | Influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are respiratory pathogens that continue to challenge global health due to their efficient transmission and ability to circumvent virus-specific treatments. Targeting host factors that are essential for viral replication may enable the de... |
41736868 | Binary solvent-assisted solvothermal approach for the synthesis of α/γ-MnS for supercapacitor applications. | Manganese sulfide (MnS) has received attention as an outstanding electrode material for supercapacitors, demonstrating high theoretical capacitance, environmental safety, lower production costs, and superior conductivity. Among its phases, α-MnS is the best phase for supercapacitors because of its cubic structure, whic... |
41717503 | Molecular contrast agents for post-infarct cardiac remodelling: a contemporary review. | Myocardial infarction (MI) is a leading cause of mortality, affecting 3.8% of the global population under 60 years of age, and 9.5% over 60 years. Adverse post-MI remodelling is the main contributor to heart failure, conferring a three- to six-fold increase in risk of premature death. Current imaging modalities, such a... |
41717002 | Functional characterization of CASP, a <i>CUX1</i> isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling. | CUT-like homeobox 1 (<i>CUX1</i>) is a transcription factor with dual roles in tumorigenesis. Among its splice variants, the Golgi-localized cut alternative spliced product (CASP) lacks DNA-binding domains, and its functional significance has remained largely unexplored. In this study, we identify CASP as a potential o... |
41716991 | Following the central dogma: Nanopore sequencing from DNA and RNA to proteins. | The first nanopore-based sequencer was launched in 2014, and subsequently, nanopore played an irreplaceable role in disclosing the first complete, gapless sequence of a human genome in 2022 due to its megabase-scale read lengths. However, a striking revelation from DNA sequencing is that over 95% of human DNA does not ... |
41716989 | Bound states in the continuum: From fundamental physics to emerging photonic paradigms. | Bound states in the continuum (BICs) defy the conventional intuition of open photonic systems by supporting perfectly localized eigenmodes within the radiative spectrum. Originally conceived in quantum mechanics and later realized in photonics, BICs have evolved from a theoretical curiosity into a unifying framework fo... |
41716343 | Strontium-luteolin nanoparticles promote M2 macrophage polarization and accelerate acute wound healing via immune microenvironment regulation. | Precise spatiotemporal control of inflammation serves as an effective means to regulate the inflammatory microenvironment and promote wound healing. This study constructed strontium‒luteolin (Sr‒Lut) nanoparticles with a spherical morphology, which demonstrated outstanding radical scavenging capacity through synergisti... |
41710741 | Influence of Lipid Composition on Nonspecific Interactions of Serotonin with Model Membranes. | Serotonin is a monoamine neurotransmitter, which plays an important role in the development and functioning of the central nervous system. Recent biophysical studies reveal that nonspecific interactions between serotonin and lipid membranes significantly alter lipid bilayer properties, impacting synaptic function and p... |
41698742 | A near-infrared ratiometric fluorescent probe for visual sensing of H<sub>2</sub>S and monitoring its fluctuation in plant roots under drought and flooding stresses. | <h4>Background</h4>Hydrogen sulfide (H<sub>2</sub>S) is a key endogenous gasotransmitter involved in plant physiological regulation and stress responses. Monitoring its dynamic changes in plants is essential for understanding related signaling mechanisms. However, due to its chemical instability and the complexity of p... |
41696359 | Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens. | The rapid escalation of antimicrobial resistance (AMR) has rendered many conventional antibiotics ineffective, emphasizing the need for alternative therapeutic approaches. Probiotics have emerged as promising biotherapeutic agents capable of inhibiting multidrug-resistant (MDR) pathogens through diverse mechanisms, inc... |
41696361 | Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety. | <h4>Background</h4>Ulcerative colitis (UC) is subtype of inflammatory bowel disease that is frequently comorbid with anxiety disorders. However, effective dual-targeting therapies are still lacking. Hyperoside (HYP), a natural flavonoid, exhibits anti-inflammatory and neuroprotective properties, yet its potential thera... |
41696358 | AMPylation: key roles in biological regulation across prokaryotes and eukaryotes. | AMPylation, as a crucial post-translational modification, is widely present in both prokaryotes and eukaryotes, playing a key role in regulating biological functions. The regulation of biological functions by AMPylation is a complex and diverse process. In prokaryotes, AMPylation plays a role in processes such as self-... |
41696333 | Advanced Electrospun Nanofibers for Photocatalytic Degradation: Sustainable Solutions for Wastewater Remediation. | The growing contamination of water resources from industrial effluents, agricultural runoff, medical sources, and domestic sources demands an advanced, sustainable solution in wastewater remediation. Photocatalysis is a widely used technique for treating wastewater by degrading complex pollutants into simpler compounds... |
41696338 | Unveiling Supramolecular Structures Formed by Menthol and Xanthan Gum in Oleic Acid-Based Microemulsions. | Microemulsions (MEs) are delivery systems that can enhance the rate of drug dissolution due to their supramolecular structure. However, adding drugs, such as menthol, and thickness agents, like xanthan gum (XG), can significantly modify these nanoscaled architectures. This study aimed to understand the mechanistic basi... |
41696326 | Orientational Order in the Liquid-Crystal Surface Induced by the Evaporation of Water Droplets. | The evaporation of a droplet induces a variety of ordered patterns near the contact line between the droplet and a substrate. This pattern formation involves both the behavior of colloidal suspensions and interactions between a droplet and a substrate. Although studies on the effect of the behavior of colloidal suspens... |
41696314 | Optimization of Chemical Flooding Injection System and Enhanced Oil Recovery after Water Flooding in Block J16, Liaohe Oilfield. | To address the pronounced heterogeneity and preferential water channeling through high-permeability zones in the medium- to high-permeability reservoirs of Block J16, Liaohe Oilfieldfactors that constrain recovery and limit the effectiveness of water floodingthis study systematically investigates chemical-flooding st... |
41696294 | Structural Properties of Coniferyl Alcohol-Based Low Transition Temperature Mixtures. | This study examines the structural organization of low transition temperature mixtures (LTTMs) based on coniferyl alcohol, a primary monolignol, at the macroscopic and microscopic levels. The work presents the first investigation into the use of lignin-derived monomers as constituents of LTTMs. The LTTMs prepared with ... |
41696310 | Bacterial Cellulose/Poly(vinyl alcohol)/Chitosan Films: Tuning Mechanical and Functional Properties for Sustainable Food Packaging. | This work reports a novel, green, and scalable wet mixing approach to prepare bacterial cellulose (BC)/poly-(vinyl alcohol) (PVA)/chitosan (CH) composite films with precise control over barrier, mechanical, and antimicrobial properties, suitable for active food packaging. The resulting composites exhibit tunable water ... |
41696290 | Transition-Metal-Free One-Pot Synthesis of (Hetero)chalcones with Cysteine Protease Inhibitory Activity. | We report a new and efficient one-pot methodology for the synthesis of (hetero)-chalcones via direct C-H functionalization. The protocol employs directed organolithiation of aromatic and heteroaromatic substrates, followed by in situ formylation using inexpensive DMF, which not only serves as the formylating agent but ... |
41696241 | Polymer/Titania Composites for the Remediation of Water from Pharmaceuticals: A Review. | Clean water is a limited resource that is essential to human existence. Pharmaceuticals have been developed to improve the health and safety of living beings. Still, their widespread application and consumption, along with their increased industrial production and subsequent improper disposal, have resulted in unpreced... |
41696240 | Reversing the Photovoltage of a Photoacid in Aqueous Glycerol and Ethylene Glycol Solutions. | Pyranine is a photoacid, which upon illumination in water, deprotonates. It has been well studied and can therefore be used as a model system for developing sensors and energy-harvesting devices based on photoacids. Under normal circumstances, the release of protons results in an open-circuit voltage of a fixed polarit... |
41696224 | Flexible Continuous Sweat Glucose Electrochemical Sensor Based on Ni/Co-MOF@PPSF. | Flexible electrochemical sensors based on noninvasive materials can continuously monitor blood glucose levels in sweat, making them ideal for personal diabetes management intelligent devices. It is necessary to construct sweat glucose electrochemical sensors that have the ability to both adjust to human skin and reliab... |
41696156 | Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment. | Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and sustained skin inflammation. Cuproptosis, a novel regulated cell death pathway, inhibits proliferation by promoting cellular demise, offering a promising therapeutic strategy for psoriasis. Herein, we first identif... |
41695989 | Beneficial effects of berberine in the treatment of diabetes and its complications. | Coptis chinensis (Huanglian), a key component in numerous classical Chinese herbal formulas, is traditionally applied for treating metabolic diseases based on its activity including clear heat, dry dampness, purge fire, and detoxify. Berberine (BBR), one key active component from Coptis chinensis, was contained in nume... |
41695962 | A series of quaternary ammonium salt antibacterial agents synthesized and prepared for constructing and screening antibacterial coatings with biosafety on polypropylene. | Diseases caused by bacteria have become the world's largest threat, and the treatment of bacterial infections urgently needs to be addressed. However, the abuse of antibiotics leads to superbugs, making bacterial infections more difficult to resolve. Therefore, there is an urgent need to develop new antibacterial agent... |
41695949 | Synergistic bactericidal activity of a ginsenoside-copper nano-agent against gram-positive and gram-negative biofilm bacteria. | <h4>Background</h4>Biofilm-associated infections pose a formidable challenge due to their high tolerance to conventional antibiotics. While copper-based therapies offer a promising avenue, their clinical utility is severely limited by non-specific cytotoxicity and rapid deactivation. To address this, we engineered an i... |
41694349 | Immune cell dynamics and mechanisms of epithelial injury in celiac disease. | Despite continuous exposure to dietary and microbial antigens, the intestinal mucosa maintains a delicate balance between immune activation and tolerance. This equilibrium depends on the integrity and regulatory functions of the intestinal epithelium and associated immune cells. In the case of celiac disease (CD), glut... |
41683797 | Mining the Hidden Pharmacopeia: Fungal Endophytes, Natural Products, and the Rise of AI-Driven Drug Discovery. | Emerging from millions of years of evolutionary optimization, Natural products (NPs) remain unique, unparalleled sources of bioactive scaffolds. Unlike synthetic molecules engineered around single therapeutic targets, NPs often exhibit multi-target, system-level bioactivity, aligned with the principles of network pharm... |
41683779 | Recent Advancements in Bioactive Natural Products and Nanoparticle-Mediated Drug Delivery in Cancer Therapy. | Cancer remains a leading cause of death worldwide, necessitating new treatment strategies. Bioactive natural products are a promising source of anticancer drugs because of their complex structures and ability to target multiple pathways, such as inducing apoptosis and inhibiting angiogenesis. However, issues like poor ... |
41683773 | Bridging Molecular and Bulk Nonlinearities: Kerr Effect Phenomena in Transparent Ceramic Systems. | Transparent ceramics offer a uniquely accessible platform for examining Kerr-type optical phenomena through the lens of molecular structure and local electronic interactions. This review highlights both the magneto-optical (MOKE) and electro-optic (EOKE) forms of the Kerr effect and relates them to the accompanying Far... |
41683760 | Sub-Internal Limiting Membrane Hemorrhage: Molecular Microenvironment and Review of Treatment Modalities. | Sub-internal limiting membrane (sub-ILM) hemorrhage is a distinct preretinal bleeding entity in which blood accumulates between the ILM and the retinal nerve fiber layer (RNFL), forming a sharply confined compartment. The ILM's low permeability and lack of immune cell access create a stagnant microenvironment in which ... |
41683758 | VOCs Profiling and Quality Assessment of Milk Employing Odorant-Binding Proteins-Based Fluorescence Biosensor. | The quality of cow's milk is critical for human nutrition; thus, it is important to develop rapid, sensitive, and cost-effective methods to monitor milk quality. Volatile Organic Compounds (VOCs) from milk are odorant molecules that can be used as key indicators of milk quality, since their presence is influenced by im... |
41683453 | Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs. | Histone lysine acetylation is a widespread posttranslational modification, essential for vital functions in eukaryotic organisms. Histone lysine acetyltransferases (KATs) employ acetyl-coenzyme A as a universal acetyl donor for acetylation of lysine residues in histone and non-histone proteins. Despite the biomedicinal... |
41683451 | Structural Basis and Inhibitor Development of SARS-CoV-2 Papain-like Protease. | Papain-like protease (PLpro), a crucial functional domain of the SARS-CoV-2 non-structural protein 3 (nsp3), plays a dual role in both hydrolyzing viral polyprotein precursors and modulating host immune responses. These critical functions position PLpro as a key target in the ongoing development of antiviral therapies ... |
41683444 | Neuroinflammation as a Central Mechanism in Alzheimer's Disease: Therapeutic Insights from Schiff Base Derivatives. | Despite decades of intensive research, an effective cure for Alzheimer's disease (AD) remains elusive. Although AD is classically linked to amyloid-beta (Aβ) aggregation, growing evidence highlights neuroinflammation as a major driver of disease progression. Neuroinflammation forms a self-amplifying cycle involving var... |
41683052 | A Konjac Glucomannan-Based Antibacterial Packaging Film with Humidity-Triggered Release of Cinnamaldehyde. | To meet the challenge of microbial contamination of food, smart packaging materials with active controlled-release functions have become a research hotspot. In this study, a humidity-responsive antimicrobial composite film was constructed by introducing cinnamaldehyde@β-cyclodextrin inclusion complexes (CIN@β-CD ICs) i... |
41682076 | Characterization of Electron Beam-Induced Polymerization of Isodecyl Methacrylate, Benzyl Methacrylate, and Their Equimolar Mixture Based on Monomer Properties. | The study examined the polymerization of methacrylic acid derivatives with bulky substituents (isodecyl-, benzyl-), as well as the synthesis of their copolymer through radiation initiation followed by thermal treatment. It has been discovered that the polymerization rate in equimolar monomer mixtures substantially surp... |
41681573 | Chemical and Ultrastructural Changes in the Cuticle Observed in <i>RabA2b</i> Overexpressing Plants. | The plant cuticle is a hydrophobic layer covering the cell wall that protects cells from pathogen invasion and water loss. In this study, we analyzed the cuticles of transgenic <i>Arabidopsis thaliana</i> plants overexpressing the vesicular trafficking small GTPase <i>RabA2b</i>. The <i>RabA2b</i>-overexpressing plants... |
41681227 | Selective Gold Recovery from Waste Electronics: A Speciation-Based Recycling Approach. | Waste electrical and electronic equipment (WEEE) is a rapidly growing waste stream rich in precious metals, with gold in particular being concentrated in printed circuit boards and other high-value components. Historically, industrial recycling has relied on pyrometallurgy and non-selective hydrometallurgical leaching.... |
41675418 | Mechanism-guided design of specific-activated photosensitizers for precision photodynamic therapy. | The clinical application of conventional photodynamic therapy (PDT) is often limited by the nonspecific phototoxicity of "always-on" photosensitizers. Activatable photosensitizers (aPSs) have emerged as a promising solution to this challenge. These smart agents are designed to remain inactive under normal physiological... |
41674691 | Anthocyanins from Rosaceae fruits: diversity, bioactivity, and potential as natural colorants. | Anthocyanins are water-soluble flavonoid pigments responsible for red, purple, and blue hues in plant tissues. Rosaceae fruits-including blackberries, raspberries, strawberries, cherries, and apples-are rich sources of anthocyanins with notable antioxidant potential. This review highlights the diversity, extraction tec... |
41660120 | A paradigm shift from penetration: Material-based solutions for multidimensional spatiotemporal, hypoxic, and optical challenges in cutaneous photodynamic therapy. | Despite considerable advancements in pharmaceutical strategies (e.g., nanocarriers, physical enhancement) to overcome the skin barrier for topical photodynamic therapy (PDT), clinical translation remains impeded by unresolved challenges. While previous reviews have predominantly focused on enhancing photosensitizer per... |
41658863 | Antibacterial activity of peptide derivatives of dermaseptins against multidrug-resistant <i>Klebsiella pneumoniae</i> and Staphylococcus epidermis. | The emergence of infections caused by multi-drug resistant bacteria (MDR) to antibiotic treatments poses a significant challenge in the healthcare field. Indeed, the resistance of MDR such as: <i>Klebsiella pneumonia</i> and <i>Staphyloccus epidermidis</i> to antibiotics has become an increasingly concerning issue, esp... |
41657946 | Body-responsive shape-memory polymers for biomedical applications. | Shape memory polymers (SMPs) have emerged as versatile and adaptive materials in healthcare, offering transformative solutions for tissue repair and biomedical device interfaces. Their ability to undergo controlled shape changes in response to external stimuli has driven significant interest in developing smart implant... |
41657947 | A multifunctional injectable MPDA@MTIC-Co hydrogel platform for synergistic chemotherapy-photothermal therapy of postoperative glioblastoma. | Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, with inevitable postoperative recurrence due to incomplete resection and limited chemotherapy efficacy. Temozolomide (TMZ), the first-line therapy, is hindered by rapid degradation of its active metabolite 3-methyl-(triazene-1-yl)-imida... |
41657945 | Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application. | Tissue regeneration is orchestrated by both intracellular signaling programs and extracellular matrix remodeling. Glycosaminoglycans (GAGs) are essential sugar chains ubiquitously expressed throughout the body. Their spatiotemporal turnover is an important part of normal organ biology and essential to tissue repair fol... |
41650589 | A self-assembled protein nanocage as a universal influenza vaccine induces enhanced broadly cross-reactive immunity. | Proteins are an effective platform for vaccine design by enabling multivalent antigen presentation and stabilizing antigen structures to enhance immunogenicity. This study investigates the molecular design and ability to position antigens on self-assembled protein nanocages (SAPNs) as a universal influenza vaccine, inc... |
41643425 | Integrating efficient signal amplification and magnetic separation into a homogeneous electrochemical strategy: Achieving ultra-low background simultaneous detection of aflatoxin B1 and ochratoxin A. | Coexisting aflatoxin B1 (AFB1) and ochratoxin A (OTA) can produce synergetic toxic effects, particularly carcinogenicity, highlighting the importance of their simultaneous detection. Although homogeneous strategies can avoid cross-interference on the electrode surface during multi-target detection, the complexity of th... |
41638186 | Hydrogel molecularly imprinted polymer-based electrochemical sensor on gold-modified screen-printed carbon electrodes for stable and selective HbA1c detection. | Glycated hemoglobin (HbA1c) is a key biomarker for long-term glycemic control and diabetes diagnosis. Common methods such as chromatography and immunoassays are accurate but require costly instrumentation, limiting their use in point-of-care settings. Electrochemical sensors offer a portable and sensitive alternative. ... |
41633060 | Entropy-driven design of non-metallic heteroatoms codoped hollow carbon nanocages for superior oxygen electrocatalysis. | The design of functional materials with increasing entropy has become a hot field in recent years. Motivated by the traditional concept of high entropy (HE), the anionic doping with multiple heteroelements towards increasing entropy has been considered to be a new clue to design highly efficient catalysts. In present w... |
41607219 | Renovating Neural Networks With Viral-Mediated Gene Transfer From A Tissue Contacting Matrix Mimic. | Neurodegenerative diseases such as Huntington's Disease (HD) have a significant impact on healthcare accessibility and costs. A fatal genetic condition, characterized by the progressive loss of striatal neurons, HD is hindered by the lack of endogenous repair in the adult brain. Recent efforts toward protecting neural ... |
41607203 | Charge Directed Selective Co-Assembly of Ionic Complementary Peptide Binary Mixtures. | Multicomponent peptide nanostructures offer a powerful platform for designing functional materials, yet controlling their co-assembly remains a key challenge. Here, we harness electrostatic molecular recognition to drive the selective co-assembly of five amphiphilic ionic peptide binary mixtures (M<sub>1</sub>-M<sub>5<... |
41605925 | AACRNL evolved from virulence factor to epigenetic parasite driving genome expansion in free-living eukaryotes. | Crinkler effectors are iconic toxins deployed by pathogens to suppress host immunity, a function long thought exclusive to pathogenic species. Here, we uncover a striking evolutionary twist: an ADP-ribosyltransferase-associated Crinkler-like protein that has repurposed its toxin-derived activity to function as an epige... |
41607267 | Hydrogen and Halogen Bond Interactions with 2,6-Dimethoxypyridine. | Raman spectroscopy and computational chemistry are used to explore the effects of noncovalent interactions with the nitrogen-containing building block 2,6-dimethoxypyridine (DMOP). Previously, we have shown that hydrogen and halogen bonding with simple nitrogen containing heterocycles lead to partial charge transfer an... |
41606647 | Singlet oxygen-precharged injectable hydrogel triggers ferroptosis and lactate metabolism reprogramming for enhanced colorectal cancer immunotherapy. | Photodynamic therapy (PDT) holds significant potential for tumor treatment, yet its immunotherapeutic efficacy is severely constrained by the immunosuppressive tumor microenvironment (TME) marked by lactate accumulation, hypoxia, and glutathione (GSH) overexpression. To overcome these limitations, we engineered an inje... |
41608831 | Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly. | Hydrogels often have poor mechanical properties due to their high water content and low polymer concentration, which limits their utility in applications that require them to withstand applied forces. Inspired by natural biopolymers such as collagen and actin, which form highly extended fibrillar networks that stiffen ... |
41607244 | Regulated Zinc-Based Organic Frameworks by Linker Functionalization for Multifunctional Photocatalysis and Photoelectrocatalysis. | Reactive oxygen species (ROS) play a critical role in driving photocatalytic reactions. The predominant type of ROS generated determines the efficiency and feasibility of diverse photocatalytic transformations. However, limited research has focused on the targeted generation of ROS tailored for diverse catalytic transf... |
41607235 | Heterointerfacial and Architectural Engineering in MOF-Templated Corn-Like FePS<sub>3</sub>-ZnPS<sub>3</sub>-C@NC Anode for Durable Sodium Storage. | 2D layered transition metal thiophosphites (MPS<sub>3</sub>) are promising high-capacity anodes for sodium-ion batteries (SIBs) but are plagued by poor conductivity and severe volume changes. To address these challenges, we report a corn-like multi-MPS<sub>3</sub> heterostructure engineered via a sophisticated MOF-on-M... |
41624944 | Fire-resistant polymer composites based on mineral fillers. | This review examines the role of mineral fillers in improving the fire resistance property of polymer composites during combustion. The mechanism of action of mineral filler particles and the nature of changes in the fire resistance of composites depending on the ratio of components in the mixture are considered. The s... |
41624931 | Enhanced controlled drug delivery of berberine-loaded gelatin nanoparticles: characterization and <i>in vitro</i> assessment. | Berberine (BBR), a natural isoquinoline alkaloid, has long been recognized for its potent antimicrobial properties. However, BBR's therapeutic potential remains limited due to its poor bioavailability, low solubility, and short biological half-life. Nanoencapsulation of BBR within a suitable carrier system represents a... |
41624930 | Synthesis of the dumbbell AuNRs@BCP nanoparticles <i>via</i> UV light-initiated RAFT polymerization-induced self-assembly. | Herein, we report a novel method to synthesize the dumbbell AuNRs@BCP nanoparticles <i>via</i> UV light-initiated RAFT polymerization-induced self-assembly <i>in situ</i>. This strategy provides a promising alternative for synthesizing asymmetric inorganic/polymeric hybrid nanoparticles with tunable morphologies. Shape... |
41624251 | Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine. | Hydrogels, with excellent hydrophilicity and high-water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine. On account of the natural mimicry of extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, and tunable functionality, t... |
41624177 | Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management. | Tendinopathy is a musculoskeletal disorder characterized by severe pain that may persist for weeks or months, often resulting in disability. Existing treatments primarily consist of conservative interventions, including rest, nonsteroidal anti-inflammatory medications, localized corticosteroid injections, ultrasound, b... |
41624179 | Bentonite-Based Functional Nanoclay Enhances Bacteriophage Therapy against Enteric Infections via Toxin Adsorption and Microbiome Recovery. | Diarrheal infections caused by antibiotic-resistant <i>Escherichia coli</i> pose a serious threat to human and animal health, driving the need for innovative therapeutic strategies. This study introduces a dual-action strategy that integrates bacteriophage EC.W2-6 with bentonite to enhance bacterial clearance and macro... |
41608807 | Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution. | Despite the theoretical advantages of phosphorus single-wavelength anomalous diffraction (P-SAD) for nucleic acid phasing, its application remains limited due to high atomic displacement parameters and an unfavourable ratio of unique reflections to anomalous scatterers. In this study, we report the crystal structure of... |
41621308 | Design and characterization of β-cyclodextrin-encapsulated walnut peptide-calcium-zinc chelates: physical characteristics, bitterness masking, stability, and sustained release. | To overcome the application bottlenecks of low solubility, strong bitterness, and poor stability of walnut peptide‑calcium‑zinc chelates, this study developed a green microencapsulation method based on β-cyclodextrin(β-CD). By optimizing the mass ratio of the chelate to β-CD, the encapsulation efficiencies of calcium a... |
41620168 | The regulation characterization of novel transcription regulator JTY_2262 in Mycobacterium bovis BCG. | Mycobacterium tuberculosis (Mtb) can survive for a long time in vivo and evade host immune attacks, primarily through transcriptional regulation mediated by transcription regulators. JTY_2262 (homologous with Rv2250c) belongs to the Tetracycline Repressor (TetR) family of regulators, and its function is currently uncle... |
41619912 | Rapid detection of NDM-producing carbapenem-resistant Escherichia coli using MALDI-TOF MS combined with machine learning techniques. | <h4>Background</h4>Carbapenem-resistant Escherichia coli (CREC) producing New Delhi metallo-beta-lactamase (NDM) poses a substantial threat to global public health. Prompt detection of CREC is essential for effective patient management and to curb the spread of resistance.<h4>Objective</h4>This study aims to establish ... |
41616826 | Phosphatidylserine transporters ORP5 and ORP8 control cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. | Phosphatidylserine (PS), the most abundant negatively charged phospholipid in mammalian cells, is made in the endoplasmic reticulum (ER) but concentrated in the plasma membrane (PM). Similarly, cellular cholesterol is synthesized in the ER, yet enriched in the PM. Recently, PS has been shown to govern the transport of ... |
41616732 | Picomolar chloramphenicol detection by orchestrating multi-level signal systems of metal-organic frameworks-catalytic hairpin assembly-gold nanoprobes. | Chloramphenicol (CAP), a broad-spectrum antibiotic, faces stringent regulatory restrictions in clinical and food safety applications due to its severe toxicity. In practical scenarios, achieving highly sensitive and rapid detection of ultralow-level CAP presents a significant challenge in sensor system design. Here, we... |
41612694 | Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. | Oligonucleotide therapeutics are a new class of drugs that enable robust and sustained modulation of gene expression. However, achieving efficient delivery of small interfering RNAs (siRNAs) to tumors is a challenge for therapy. Here, we demonstrate that fully chemically modified siRNAs conjugated with an albumin-bindi... |
41612638 | Shape-Memory-Assisted Self-Healing and Real-Time Acidic Environment Detection in Multifunctional Electrospun Fibers. | Smart fiber systems that integrate self-healing and environmental responsiveness are emerging as promising candidates for wearable electronics, protective clothing, and adaptive textiles. Here, we report a multifunctional electrospun fiber platform combining shape-memory-assisted self-healing with acid-triggered chromi... |
41612636 | A Crystalline In(II) Hydride. | Low oxidation state hydride species of heavier main-group elements are notoriously elusive due to their intrinsic instability and rapid decomposition, generating hydrogen. Nevertheless, they offer significant potential for small-molecule activation and catalysis. Herein, we report the synthesis and characterization of ... |
41612612 | Controlling Aggregation-Induced Emission by Sterics in Nitrogen-Boron-Nitrogen (NBN)-Doped Tetraphenylethylene-Like Molecular Propellers. | The phenomenon of aggregation-induced emission (AIE) serves as a promising tool to harness and boost emission properties in luminescent materials. Here, we report nitrogen-boron-nitrogen (NBN)-substituted molecular propellers with different degrees of steric hindrance. Photoluminescence measurements demonstrated that e... |
41612598 | A Skin-Effect and Ion-Pumping Inspired 3D Solar Evaporator With High Salt Resistance for Sustainable Desalination. | Solar-driven interfacial evaporation holds promise for addressing freshwater scarcity, yet its long-term performance is compromised by salt fouling. Herein, we present a 3D dispersed interfacial evaporator that synergistically integrates the "skin effect" and "ion-pumping effect" to enhance vapor generation and salt re... |
41612488 | Identification of the biomarkers associated with lipid metabolism and endoplasmic reticulum stress in pediatric sepsis through bioinformatics analysis and quantitative reverse transcriptase PCR (qRT-PCR) assay. | <h4>Background</h4>Sepsis constitutes a critical clinical condition characterized by organ failure and systemic inflammation, especially affecting children. Lipid metabolism and endoplasmic reticulum stress are involved in various diseases, yet their roles in pediatric sepsis remain unclear. This study sought to discov... |
41612406 | Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation. | Phase separation is an important process in biology associated with formation of membraneless organelles but possibly related to the emergence of solid inclusions. TDP-43 is a largely studied paradigmatic case, as it forms neuronal cytoplasmic inclusions in neurodegenerative diseases and is an essential component of ma... |
41612320 | Functional design of anastomotic staples in gastrointestinal surgery: mechanistic insights and clinical translation. | Titanium alloy anastomotic staples are widely used in gastrointestinal surgery due to their ability to reduce operative time and standardize anastomotic construction. The developmental focus of these devices has evolved from ensuring basic mechanical reliability toward improving biocompatibility and, more recently, tow... |
41612267 | Nanoparticles based on photothermal effects in the treatment of hepatocellular carcinoma (HCC): a meta-analysis and systematic review. | <h4>Background</h4>Hepatocellular carcinoma (HCC) is a highly lethal form of cancer with a global mortality rate that is unparalleled among malignant tumours. The photothermal effect exhibited by nanoparticles offers a novel approach for the treatment of HCC. To perform a systematic review and meta-analysis on the ther... |
41611918 | Exceptionally selective voltage-sensor trapping of Na<sub>V</sub>1.5 channels by Mg-protoporphyrin impairs cancer cell migration. | The human voltage-gated sodium channel hNa<sub>V</sub>1.5 is essential for cardiac excitability. Though underrecognized, Na<sub>V</sub>1.5 is also expressed in multiple cancers, promoting cell migration and malignancy. hNa<sub>V</sub>1.5 is a therapeutic target but limited pharmacological isoform specificity presents a... |
41611892 | Efficacy and safety of a novel ab interno supraciliary HA-Mg biodegradable glaucoma drainage plate implantation in rabbit eyes. | The uveoscleral outflow pathway is one of the important pathways for aqueous humor outflow. Implanting ab interno glaucoma drainage devices through this pathway does not require conjunctival filtering bleb formation, thereby avoiding bleb-related complications. However, permanent drainage devices can easily cause damag... |
41611823 | Indirect ubiquitination independent of endogenous ubiquitination machinery for targeted protein degradation. | Heterobifunctional small degrader molecules that hijack endogenous E3 ubiquitin ligases have attracted attention for the rapid and irreversible knock-down of target proteins via ubiquitination. However, the formation of appropriately oriented E3 ligase-target complexes is required for efficient ubiquitination of the ta... |
41611807 | SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion. | The SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines. Complement system dysregulation in COVID-19 patients led us to h... |
41611810 | Steric confinement-induced emission probe for monitoring protein conformations in live cells. | Protein conformational changes drive signal transduction to regulate cellular activities, yet monitoring of these changes in living cells remains challenging. Here, we introduce BIOSCE (BIOprobe based on Steric Confinement-induced Emission), a technique that enables tracking of individual protein conformations in livin... |
41611739 | Structural elucidation, biological significance and computational approach of Copper(ii), Nickel(ii) and Cobalt(ii) with bidentate schiff base of N-(Napthalene-1-ylmethylene)isonicotinohydrazide. | The increasing prevalence of antibiotic-resistant bacteria and oxidative stress-related diseases underscores the need for novel therapeutic agents with potential dual functionality. In this research, a schiff base ligand, N-(Napthalene-1-ylmethylene)isonicotinohydrazide, was synthesized and complexed with Copper(II), N... |
41611719 | Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring. | Piezoelectric materials provide a unique platform for bioelectronic interfaces, enabling dynamic sensing and electroactive therapies through bidirectional transduction between biomechanical and bioelectrical signals. However, the development of bioresorbable piezoelectric materials that combine high functional performa... |
41611701 | ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis. | Targeting the protein quality control system in Mycobacterium tuberculosis represents a promising and underexplored opportunity for antibiotic development. The ClpC1:ClpP1P2 protease is an essential component of the system that mediates both regulatory and stress-related protein degradation. Several non-ribosomal pepti... |
41611699 | A lattice oxygen-free design for efficient and stable photothermal methane dry reforming. | Photothermal dry reforming of methane, a promising approach to producing syngas, typically uses oxide materials and is mediated by lattice oxygen. However, it is limited by the balance of the oxygen-releasing/replenishing loop. Here, we present a methane activation pathway free of lattice oxygen on a N-Ni/NiCo@C cataly... |
41611694 | Multidimensional helical dichroism from a chiral molecular nanoassembly. | Detecting the chirality of molecules is of great importance in optics, biomedicine, and materials science. In chiroptical spectroscopy, it's crucial to achieve strong chiroptical signals with a minimal number of chiral molecules. The molecular chiroptical signals, however, are typically weak for chiral molecular sensin... |
41611670 | Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs. | Non-compressible hemorrhage remains the chief cause of battlefield mortality and civilian trauma death. Here, we propose a hemostatic strategy based on ultrafast self-gelling self-expanding powder of polyacrylic acid (PAA), polyethyleneimine (PEI) and foaming agent, which achieves non-compressible hemorrhage hemostasis... |
41611522 | Biological Activity and Structural Biology of Current KAT6A Inhibitor Chemotypes. | All lysine acetyltransferases (KATs) modulate biological outcomes through the acetylation of lysine side-chain amino groups facilitated by acetyl coenzyme A (AcCoA). KAT6A belongs to the class of MYST domain histone acetyltransferases (HATs), which had been regarded as undruggable. The first on-target KAT6A inhibitors ... |
41611307 | Parameter-Free Determination of Au Nanorod Dimensions Using Depolarized DLS and Genetic Optimization. | Gold nanorods (AuNRs) have received considerable attention for their distinctive optical properties and well-defined, low-polydispersity dimensions. These characteristics position them as promising candidates for diverse applications in imaging, sensing, and treating diseases. However, accurate characterization of AuNR... |
41611216 | Silica-Based Porous Adsorbents for Efficient 17α-Ethinylestradiol Removal: Role of Organic Functionalization and Water Matrices. | Three silica-based porous adsorbents, MCM-41 (pure silica), vinyl-MCM-41 (hybrid silica), and Ph-PMO (periodic mesoporous phenylene-silica), were tested to evaluate the effect of organic functionalities on removing the hormone disruptor 17α-ethinylestradiol (EE2) from water. Different adsorbent dosages were tested in u... |
41610373 | Gel Electrolyte Self-Healing via Dynamic Reversible Bonds for Stable Lithium Plating/Stripping in Lithium Metal Batteries. | Solid polymer electrolytes in lithium metal batteries (LMBs) are susceptible to mechanical damage from lithium dendrite puncture and deformation. Although integrating self-healing functionality helps to alleviate this issue, it typically compromises either mechanical strength or ionic conductivity. To overcome this tra... |
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