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41610344 | Naked-Eye Visual Warning of ppm<sub>v</sub>-Level Fault-Free Humidity Upper Limit. | Monitoring and warning of ppm<sub>v</sub>-level fault-free humidity upper limit (ppm<sub>v</sub>-FFHUL) are crucial for ensuring system reliability in critical fields such as high-tech manufacturing, and aerospace. However, existing ppm<sub>v</sub>-FFHUL warning technologies are scarce, and constrained by "gradual chan... |
41610328 | From Evaporation to Self-Assembly: Deposition Kinetics and Mechanisms of Nanoparticles in Colloidal Droplets. | The self-assembly of nanoparticles (NPs) represents a key strategy for fabricating 2D functional nanostructures. However, achieving precise control over deposition kinetics remains challenging due to the complex multiphase interactions within the Substrate-Droplet-NP system, limiting the self-assembly quality. Here, we... |
41610327 | Sensitive Homogeneous Electrochemical Detection of Organophosphorus Pesticides by UiO-66-NH<sub>2</sub> Embedded with a Ruthenium-tris(2,2'-bipyridyl)(II) Nanozyme. | This study prepared UiO-66-NH<sub>2</sub> MOFs embedded with Ru-tris(2,2'-bipyridyl)(II) hybrids as a nanozyme (designated as Ru/UiO-66-NH<sub>2</sub>) to propose a bioenzyme-free homogeneous electrochemical (HEC) sensing strategy for detecting organophosphorus pesticides (OPs). Experimental investigation coupled with ... |
41610331 | Engineering Interfacial Donor-Acceptor Molecular Cocrystals. | Y6 is a high-performance non-fullerene acceptor widely used in organic solar cells. The assembly behavior of Y6 at interfaces, however, remains mostly unknown and respective in-depth investigations are missing. Here, we use room temperature scanning tunneling microscopy to investigate the self-assembly of Y6 at the sol... |
41610155 | The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid. | Binding of the host protein cyclophilin A (CypA) to the viral capsid exerts multiple effects on HIV-1 infection, including enhancement of reverse transcription, stabilization of the capsid, and promotion of nuclear entry. CypA can also inhibit infection of selected HIV-1 mutants by a poorly understood mechanism. Using ... |
41610126 | Discovery and computational characterization of ZIKV envelope-targeted peptides from a subtractive phage display library. | The Zika virus (ZIKV) poses a significant public health threat, and developing highly specific diagnostic and therapeutic agents that can distinguish it from other flaviviruses remains a critical challenge. To address this, we utilized a phage display library with a strategic subtractive panning approach against the ZI... |
41610079 | A Supramolecular Salicylic Acid-Betaine with Superior Epidermal Benefits and Better Tolerance: In vitro Proof of Concept Studies. | <h4>Introduction</h4>Recent progress in supramolecule research has led to a surge in its application in cosmetic products. However, comprehensive investigation of the potential benefits, especially differentiating biological activities and associating that with physical-chemical properties, remains to be established. T... |
41610054 | A "Jack-of-All-Trades" Phototheranostic System Enabled by Strategic Regulation of Ferroptosis and PANoptosis for Cancer Therapy. | Phototheranostic strategies for cancer remain constrained by the availability of phototheranostic agents. Nonfullerene acceptor (NFA) materials, characterized by their distinctive structure and optical characteristics, emerge as promising candidates for the high-performance phototheranostic agents. In this work, an A-D... |
41609560 | Interlocked Rotaxane Enables TADF with Distinct Excited-State Structural Relaxation. | We present the first demonstration of a rotaxane-based thermally activated delayed fluorescence (TADF) exciplex, its unique excited-state structural relaxation and application in organic light-emitting diodes (OLEDs). The design employs a triazene cage (<b>Trz-cage</b>) as the host electron acceptor, threaded by a carb... |
41609558 | Induction of J Aggregate-like Optical Transitions in Dihydroxyquinone by Coordination with Al(III). | The metal-complex formation of 1,4-dihydroxyanthraquinone (quinizarin, QNZ) and 6,11-dihydroxy-5,12-naphthacenedione (DHN) with Al(III) ions is investigated by stationary and time-resolved emission spectroscopy combined with quantum chemical calculations of optical properties. UV-vis and fluorescence spectra revealed s... |
41609435 | Redox environment modulates aggregation of ataxin-3 in vitro - Implications for drug screening of cysteine-rich proteins. | Spinocerebellar ataxia type 3 is a debilitating neurodegenerative disorder driven by the pathological aggregation of ataxin-3 (Atx3), a deubiquitinating enzyme with a cysteine-rich catalytic domain and an expandable polyglutamine (polyQ) tract. While the role of polyQ expansion in Atx3 aggregation is well documented, t... |
41609249 | Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications. | Functionally graded surfaces and materials, featuring spatial variations in terms of composition, structure, and other properties across distance, have emerged as powerful platforms for mimicking native tissue architectures and enabling a wide range of biomedical applications. This review aims to provide a comprehensiv... |
41609019 | Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function. | The rapid and sustained proliferation of cancer cells necessitates increased protein production, which, along with their disrupted metabolism, elevates the likelihood of translation errors. Ribosome-associated quality control (RQC), a recently identified mechanism, mitigates ribosome collisions resulting from frequent ... |
41609015 | Core-Shell Structures of Bioactive Glass Nanoparticles and MIL-100 Framework: Properties and Biomedical Applications. | A novel core-shell hybrid material composed of bioactive glass (BG) nanoparticles and the metal-organic framework (MOF) MIL-100(Fe) (Fe<sub>3</sub>O(H<sub>2</sub>O)<sub>2</sub>OH(BTC)<sub>2</sub>·nH<sub>2</sub>O, BTC: 1,3,5-benzenetricarboxylate) was synthesized using a layer-by-layer strategy. The formation of the MIL... |
41608880 | Asymmetric Self-Assembled Molecule With High Dipole Moment for Efficient Wide-Bandgap Perovskite Solar Cells and Tandems. | Self-assembled monolayers (SAMs) have shown considerable promise as hole-transport layers (HTLs) in wide-bandgap (WBG) perovskite solar cells (PSCs) and tandems. However, conventional SAM materials often face limitations such as substantial energy-level misalignment and inefficient charge transport, which limit device ... |
41560552 | Functional proteomic analysis reveals <i>mglB</i>-mediated meropenem resistance and its reversal by galactose. | Salmonella enteritidis is a globally prevalent zoonotic pathogen with a broad host range and high pathogenicity, ranking among the most common serotypes within the <i>Salmonella genus</i>. The widespread and often indiscriminate use of antibiotics has driven a continual rise in antimicrobial resistance among S. Enterit... |
41527891 | Self-assembling peptides construct supramolecular materials. | Programmable peptide self-assembly enables the precise construction of supramolecular materials, establishing it as a defining frontier in nanomaterials research. This review systematically explores the collective contribution of sequence design, secondary structure regulation (including α-helices, β-sheets, and cyclic... |
41524156 | Harnessing 4f-3d synergy in Ce-Fe heterostructure: a PBA-derived oxygen reservoir for stable high-capacity lithium storage. | We present a high-performance LIB anode featuring a MOF-derived CeO<sub>2</sub>/a-Fe<sub><i>α</i></sub>O<sub><i>β</i></sub> heterostructure. Electronic coupling <i>via</i> 4f-3d orbital hybridization enables a synergistic mechanism that stabilizes oxygen redox, minimizes lattice strain, and accelerates ion transport, a... |
41524094 | Molecular communication system using Zn<sup>2+</sup> selective supramolecular nanochannel to induce photoregulated catalysis. | We developed synthetic ionophores that self-assemble into supramolecular nanochannels for the transport of Zn<sup>2+</sup> across lipid bilayers. The translocated Zn<sup>2+</sup> forms a photoactive PPIX-Zn<sup>2+</sup> complex that generates <sup>1</sup>O<sub>2</sub> to oxidize tryptophan, establishing a Zn<sup>2+</su... |
41521776 | Interphasic separation of <i>cis</i>/<i>trans</i> perylene-based nanographene isomers driven by selective encapsulation in a supramolecular cage. | The present work describes a supramolecular strategy for the molecular recognition and selective separation of extended PAHs and NGs from isomeric mixtures. This approach consists of a biphasic protocol featuring the selective shuttling of a targeted NG isomer from the organic to the aqueous phase, driven by host-guest... |
41508955 | Highly efficient solar to chemical conversion by an anthraquinone and <i>Candida antarctica</i> lipase B-based photocatalytic-enzymatic cascade. | Herein, we construct a spatially coupled photo-enzymatic cascade system within a ZIF-8 framework. The host-guest interaction narrows the bandgap and prolongs the charge carrier lifetime of the photocatalysts, leading to a doubled H<sub>2</sub>O<sub>2</sub> yield <i>via</i> dual reaction pathways. Subsequent enzymatic e... |
41504440 | Toward mechanically robust liquid crystal elastomers: multiscale strategies from molecular engineering to hierarchical integration. | Liquid crystal elastomers (LCEs) uniquely couple the orientational order of mesogens with the elasticity of polymer networks, enabling reversible shape transformation under diverse stimuli. However, their practical deployment is limited by intrinsic mechanical weaknesses, including low modulus, poor toughness, and fati... |
41496628 | A reticular chemistry approach to constructing metal-organic frameworks with <i>hmc</i> topology using organic cage building blocks. | A molecular design strategy for constructing metal-organic frameworks (MOFs) from preorganized organic cage building blocks is presented. Two frameworks, MOF-POC-1 and MOF-POC-2, were synthesized and found to crystallize in the cubic <i>Fm</i>3̄<i>m</i> space group, adopting an <i>hmc</i> topology generated by using 6-... |
41493074 | Interfacial and structural transformations in Ni-rich cathodes: a roadmap toward chemical stability. | This review highlights Ni-rich layered oxide cathodes, such as LiNi<sub><i>x</i></sub>Mn<sub><i>γ</i></sub>Co<sub><i>z</i></sub>O<sub>2</sub> (NMC) and LiNi<sub><i>x</i></sub>Co<sub><i>y</i></sub>Al<sub><i>z</i></sub>O<sub>2</sub> (NCA), where <i>x</i> ≥ 0.6, <i>y</i> + <i>z</i> ≤ 0.4, and <i>x</i> + <i>y</i> + <i>z</i... |
41489611 | Research progress on the removal of iodine and fluoride by metal-organic frameworks. | Metal-organic frameworks (MOFs) have emerged as versatile platforms for the efficient removal of iodide and fluoride contaminants (inorganic fluoride (F<sup>-</sup>) and organic perfluorinated anions (PFAS)) from aqueous solutions, addressing critical environmental challenges associated with nuclear waste and groundwat... |
41489095 | Programmable PROTAC delivery for precise and spatiotemporal protein degradation. | Targeted protein degradation (TPD) using proteolysis-targeting chimeras (PROTACs) has emerged as a transformative therapeutic modality for eliminating disease-causing proteins and accessing targets previously considered "undruggable". However, the therapeutic potency of PROTACs remains limited due to their poor cell me... |
41437898 | Circularly polarized luminescent nanoparticles: preparation, performance and applications. | Circularly polarized luminescence (CPL) represents a unique optical phenomenon where emitted light exhibits a specific circular polarization, offering significant advantages in advanced photonic applications. Luminescent nanoparticles capable of CPL have garnered increasing attention due to their potential in enhancing... |
41877832 | Gan-Pi-Tong-Zhi Decoction Ameliorates OVA-Induced Asthma Through MAPK and Nrf2 Signaling Pathways and Regulating Gut Microbiota. | <h4>Purpose</h4>This study aims to investigate the therapeutic mechanism of Gan-Pi-Tong-Zhi Decoction (GPTZ) in asthma.<h4>Methods</h4>The study explored the chemical components of GPTZ by using UPLC-Q-TOF-MS, and utilized the database for target identification, and predicted potential pathways using network pharmacolo... |
41810067 | Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration. | The increasing incidence of infections and impaired tissue healing underscores the urgent need for effective therapeutic strategies for antibacterial treatment and regenerative medicine. Piezoelectric catalytic therapy represents an innovative approach that converts mechanical energy into electrochemical energy, provid... |
41783504 | Supramolecules for Pathogen Inhibition: From Polymers to Self-Assembled Nanosystems. | Vaccines and antivirals have been developed to combat virus infection, but they face the challenges of rapid and unpredictable virus mutations, which have been widely observed during COVID-19. An alternative approach is, therefore, highly needed as an additional tool to prevent virus infection. As the infection of a vi... |
41763836 | FRET/SAXS integration reveals the digestion-absorption trade-off driven by dynamic self-assembly of human milk triacylglycerols. | This study integrates fluorescence resonance energy transfer (FRET) and small-angle X-ray scattering (SAXS) to elucidate, in real time, how triacylglycerol (TAG) self-assembly dynamics in human milk regulate digestion and absorption. Among three major human milk TAGs-1-oleoyl-2-palmitoyl-3-linoleoyl-glycerol (OPL), 1,3... |
41754913 | Pharmaceutical Binary and Ternary Complexes of Gemcitabine with Aluminum Metal-Organic Framework: Mechano-Chemical Encapsulation, Delayed Drug Release, and Toxicity to Pancreatic Cells. | <b>Background:</b> gemcitabine is a cytidine analog and major anticancer drug functioning as an antimetabolite. However, its administration by systemic route is accompanied by "burst" and side effects. To limit this, drugs are encapsulated in matrices; metal-organic frameworks (MOFs) are coordination polymers with stro... |
41754766 | Phytochemical Analysis of Lipid Composition and Biological Activities in the Seeds of Evening Primrose from Bulgaria. | <b>Background/Objectives:</b> The present study is aimed at evaluating the chemical profile and biological activity of the widespread species <i>Oenothera biennis</i> L. in Bulgaria, collected from its natural habitat. <b>Methods:</b> The seeds of the species were collected in 2023 and 2024, and the fatty acid and unsa... |
41746052 | EPIclip: A Novel Approach for the Production of Decorated Virus-Like Particles Mediated by High-Affinity Protein Binding Partners. | <h4>Background</h4>Virus-like particles (VLPs) represent key tools for the development of vaccines due to their ability to induce a potent immune response to epitopes presented on their surface. However, the decoration of VLPs with a complete heterologous protein on the surface remains a bottleneck for clinical transla... |
41745917 | Computational Design and Immunoinformatic Analysis of a Broad-Spectrum Edible Multi-Epitope Vaccine Against Salmonella for Poultry. | Salmonellosis remains a persistent threat to global food safety and poultry productivity, compounded by rising antimicrobial resistance. Here, we report the in silico design and immunoinformatic validation of a broad-spectrum, edible multi-epitope vaccine targeting conserved adhesion and biofilm-associated proteins (Fi... |
41745080 | Microbiota Transplantation as a Future Novel Therapeutic Strategy Approach. | Bacterial vaginosis (BV) is a leading cause of genital discomfort among women globally, and it arises from dysbiosis of the vaginal ecosystem characterized by the overgrowth of pathogenic bacteria. Current therapeutic strategies primarily rely on antibiotics and/or probiotics, which demonstrate clinical efficacy but ar... |
41744985 | Coupled Mechanisms of Pore-Throat Structure Regulation and Flow Behavior in Deep-Water Tight Reservoirs Using Nanocomposite Gels. | Understanding how nanocomposite gels regulate pore-throat structures and flow behavior is essential for improving profile control and flow diversion in deep-water tight reservoirs. In this study, a dual-structure-regulated nanocomposite gel (DSRC-NCG) was designed, and its structure-flow coupling behavior during gel in... |
41743790 | Advances in Traditional Chinese Medicine for chronic obstructive pulmonary disease through multi-omics approaches. | Chronic obstructive pulmonary disease (COPD) is a common and complex heterogeneous chronic inflammatory airway disorder characterized by multifactorial pathogenesis and limited therapeutic options. It remains one of the leading causes of morbidity and mortality worldwide, severely impairing patients' quality of life an... |
41717017 | Engineering electron conduits in bacteria for selective biointerfacing and enhanced energy transfer. | Specialized cytochrome protein complexes conduct electrons across cell membranes in electrogenic bacteria, which enables these microbes to be harnessed for applications in electrical generation, biosensing, and microbial electrosynthesis. Here, we engineer the surface-exposed MtrC subunit from the MtrCAB complex of <i>... |
41716250 | Interfacial failure mechanisms and design principles in solid-state sodium batteries. | Solid-state sodium batteries (SSSBs) have attracted increasing attention as a promising alternative for large-scale energy storage owing to their intrinsic safety, material abundance, and potential cost advantages. Significant progress has been made in developing diverse solid-state electrolytes, including polymers, in... |
41704593 | Wheat landraces and microbiome endophytic phytases: In vitro/in silico study for iron bioavailability. | This study proposes an innovative biotechnological strategy to enhance iron bioavailability in wheat by leveraging the untapped potential of phytase-producing endophytic lactic acid bacteria and yeasts isolated from Moroccan wheat landraces. The research was predicated on the hypothesis that the endophytic microbiota o... |
41696271 | Bioluminescent Immunophage Sensors for the Quantification of Insulin. | Diagnosis and then therapeutic management of diabetes require accurate, rapid monitoring of key biomarkers. Currently, only glucose levels guide diabetes management. Reliance on one biomarker can lead to diabetes misdiagnosis and improper treatment. However, adding insulin to the diagnostic portfolio could improve pati... |
41696266 | Au-PtNPs@Mn<sub>3</sub>O<sub>4</sub> Nanozymes Enhance the Antitumor Effect of Photodynamic Therapy and Radiotherapy in Cervical Cancer by Modulating Tumor Hypoxia. | Photodynamic therapy (PDT) and radiotherapy (RT) are clinical treatment strategies for solid tumors. However, the uncontrolled proliferation of cancer cells leading to a hypoxic tumor microenvironment significantly reduces the efficacy. This study aimed to construct Au-PtNPs@Mn<sub>3</sub>O<sub>4</sub> composite nanozy... |
41696234 | Estimating the Hydrogen Bond Strength by Machine Learning Approaches. | The capabilities of machine learning approaches were investigated to predict the hydrogen bond energy based on partial charges, bond orders, bond distances, and element types. Support vector regression in combination with gradient boosting resulted in a mean absolute percentage error of 3%, which is a significant impro... |
41696229 | A Mini-Review on the Structure-Property Relationships of Octahedral Mn<sup>2+</sup> Chlorido Organic-Inorganic Hybrid Complexes: A Platform for Tunable Luminescence and Multifunctionality. | Pb-free organic-inorganic hybrid compounds are emerging as a versatile class of light-emitting materials, due to their optoelectronic, magneto-optic, field-sensing properties, low toxicity, and natural abundance. Particularly, ionic Mn<sup>2+</sup> chlorido organic-inorganic hybrid compounds display high photoluminesce... |
41685362 | Nanomaterial-based total analysis systems for isolation and detection of exosomal biomarkers in cancer diagnosis. | Exosomes are nanoscale extracellular vesicles secreted by both cancerous and healthy cells that carry a diverse array of biomolecules, including nucleic acids and proteins, reflecting the physiological and pathological states of their cells of origin. This makes them highly promising biomarkers for liquid biopsy-based ... |
41685304 | Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages. | <h4>Background</h4>Excessive inflammation mediated by macrophages impedes wound healing following surgical drainage of perianal abscess, a common yet challenging condition in colorectal surgery. <i>Cayratia japonica</i> ointment (CJO) has shown clinical efficacy, but its active immunomodulatory constituents and mechani... |
41685191 | Recent advances in mitochondria-targeted porphyrin-based metal-organic frameworks for enhanced cancer therapy. | Porphyrin-based metal-organic frameworks (MOFs) offer exceptional advantages for cancer therapy, including high photosensitizer loading, tunable nanostructures, and suppression of porphyrin self-quenching. By functionalizing with mitochondria targeting ligands, these platforms deliver reactive oxygen species (ROS) prec... |
41685066 | Sn-Decorated Cu/Cu<sub>2</sub>O Electrodes Enable Selective CO<sub>2</sub> Reduction to Formic Acid under Realistic Flue Gas Streams. | The electrochemical reduction of CO<sub>2</sub> is typically investigated under pure CO<sub>2</sub> feeds, but practical deployment must address more complex and dilute sources such as flue gases. Here, we studied Cu/Cu<sub>2</sub>O electrodes decorated with tin (Sn) synthesized using a scalable electrodeposition metho... |
41684778 | pH-responsive self-assembly of quercetin-loaded zein-sodium caseinate-fucoidan hybrid nanoparticles: nanostructure, stability and <i>in vitro</i> digestive behavior. | <h4>Introduction</h4>Quercetin (Que), a physiologically versatile flavonoid, faces application limitations in food and pharmaceuticals due to poor aqueous solubility and stability.<h4>Method</h4>To address this, we developed quercetin-loaded zein-sodium caseinate-fucoidan (Que-ZE-SC-FD) ternary nanoparticles using a gr... |
41684678 | Genomic-based biosurveillance for avian influenza: whole genome sequencing from wild mallards sampled during autumn migration in 2022-2023 reveals a high co-infection rate on migration stopover site in Georgia. | The Caucasus region, including Georgia, is an important intersection for migratory waterbirds, offering potential for avian influenza virus (AIV) transmission between populations from different geographic areas. In 2022 and 2023, wild ducks were sampled during autumn migration events in Georgia to study the genetic rel... |
41684598 | A radiotherapeutic paradox: ellagic acid sensitizes tumors while attenuating radiation-induced myocardial injury. | <h4>Background</h4>Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer lacking effective targeted therapies. Radiotherapy remains a mainstay for locoregional control, but its efficacy is limited by intrinsic tumor radioresistance and the risk of radiation-induced myocardial injury (RIMI... |
41684516 | Preparation, immunological and pharmacological effects of flavonoids in Scutellariae radix: a review. | In traditional Chinese medicine theory, Scutellaria baicalensis Georgi [Lamiaceae; Scutellariae radix] (SR) is bitter and cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It clears heat and dries dampness, purges fire and detoxifies, stops bleeding, and stabilizes... |
41683750 | Interactions Between Nutraceuticals and α-Synuclein Conformational States: Molecular Mechanisms and Neuroprotective Implications in Parkinson's Disease. | Synucleinopathies, including Parkinson's disease (PD), are neurodegenerative disorders characterized by aberrant aggregation of α-synuclein (α-syn), a presynaptic protein with an intrinsic disorder nature. The transition of soluble monomers into oligomeric and fibrillar species represents a key molecular event driving ... |
41683737 | Neighboring Alkali Cations as an Efficient Strategy for N<sub>2</sub> Activation: A DFT Analysis. | Nitrogen gas is one of the most abundant resources on Earth, serving as a fundamental component in both biological and industrial processes. Nevertheless, this simple molecule can only be activated by a limited group of microorganisms in nature. Significant efforts have been devoted to replicating this biological activ... |
41683739 | The Inclusion of Dietary and Medicinal Mushrooms into Translational Oncology: Pros and Cons at the Molecular Level. | Mushrooms are valued for their nutritional qualities and have been used in traditional medicine since the Neolithic era. They exhibit various bioactivities, including antioxidant, hypocholesterolemic, immunomodulatory, and anticancer effects. The anticancer effects arise via direct action on tumor cells and indirect mo... |
41683724 | Pluronic<sup>®</sup> F127 Polymeric Micelles as Nanocarriers for Pentamidine: Improving Safety and Biological Efficacy Against <i>Leishmania major</i>. | Cutaneous leishmaniasis (CL) is a neglected tropical disease for which current chemotherapeutic options are limited by systemic toxicity (such as hepato-nephrotoxicity, arrhythmia, nausea, vomiting) and difficult administration regimens. Pentamidine (PTM), although effective, exhibits severe dose-limiting adverse effec... |
41683434 | Microalgae Applications in the Agricultural and Food Sector: Towards a Sustainable Future. | The global population faces increasing demands for sustainable initiatives due to industrialized agriculture. To meet the demand for protein-rich foods, innovative practices must be implemented. Conventional agricultural systems face significant challenges, including soil degradation, biodiversity loss, nutrient deplet... |
41683435 | A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders. | Molecular glue degraders (MGDs) constitute a class of innovative therapeutic agents within the field of targeted protein degradation (TPD). In contrast to proteolysis-targeting chimeras (PROTACs), MGDs induce protein degradation by stabilizing the interaction between an E3 ubiquitin ligase and a target protein. They ty... |
41683430 | Nanopesticides by Design: A Review of Delivery Platforms, Environmental Fate, and Standards for Safe and Sustainable Crop Protection. | Nanopesticides are pesticide formulations in which intentionally designed nanoscale carriers shape how an active ingredient (AIng) is deposited, transformed, and released. These systems can improve retention and efficacy, but carrier complexity introduces challenges: nanomaterials can transform in real soil-water matri... |
41683429 | Valorisation of Barley Straw for Sustainable Nanocellulose Production via Subcritical Alkaline Hydrolysis and HDES-Assisted Processing. | This study investigates a sustainable and efficient approach to valorising barley straw by producing nanocellulose via an integrated subcritical alkaline hydrolysis and HDES-assisted processing pathway. Subcritical alkaline pretreatment under best processing conditions (150 bar, 200 °C, 125 min) enabled effective bioma... |
41683431 | Optimizing Lactoferrin Isolation for Functional and Structural Integrity: A Molecular Insight. | Lactoferrin (Lf) occurs predominantly within milk, coexisting with measurable levels across different glandular products and body fluids. Lf exhibits variation in relative molecular mass, influenced by its biological source and glycosylation profile; nevertheless, it is a close to 80 kDa glycoprotein. Provided that its... |
41682058 | Construction of a P/N/Zn Synergist for Enhancing the Fire Safety and Char Formation of PA6/Aluminum Diethylphosphinate Composites. | Polyamide 6 is an important engineering thermoplastic; however, its practical use is often constrained by its high flammability. Although aluminum diethylphosphinate is widely employed as a flame retardant for polyamide 6, its relatively slow char-forming kinetics hinders the attainment of the stringent 750 °C glow-wir... |
41682054 | Synthesis and Characterization of Cellulose and IPN (Cellulose/PVA) Hydrogels and Their Application in Dye Retention. | The discharge of dye-contaminated effluents from textile industries into water bodies poses a severe threat to aquatic ecosystems and human health. To address this challenge, cellulose and interpenetrating polymer network (IPN) hydrogels based on cellulose and poly(vinyl alcohol) (PVA) were developed via an in situ syn... |
41681892 | Superparamagnetic Nanoparticles Targeting Brain Cancer: Innovations in Carbohydrate-Based Coatings and Magnetic Field Guidance. | The effective treatment of aggressive brain tumors, such as glioblastoma, is critically hindered by the blood-brain barrier (BBB) and the non-specific clearance of therapeutic agents by the immune system. Superparamagnetic iron oxide nanoparticles (SPMNPs) offer a powerful theranostic platform, combining magnetic reson... |
41681212 | Polypyrrole Effect on Carbon Vulcan Supporting Nickel-Based Materials Catalyst During Methanol Electro-Oxidation. | The catalyst in methanol oxidation plays a pivotal role in direct fuel cell reaction. The aim of this work is to study the influence of polypyrrole polymer (PPy) added in the carbon Vulcan support for the methanol oxidation reaction. The catalytic active phase synthesized was nickel-based materials, which have been dem... |
41677716 | Dietary Supplementation with a 3-Selenoureidoindole Derivative Enhances Thermotolerance and Modifies the Hemolymph Amino Acid Profile in Silkworm (<i>Bombyx mori</i>). | The high bioavailability and low toxicity of organic selenium underscore its potential for nutritional fortification. This study investigated the biological effects of a novel 3-selenoureidoindole derivative (3-SeU-Ind) as a dietary selenium source in the invertebrate model organism silkworm (<i>Bombyx mori</i>). When ... |
41677616 | Development and Characterization of a Rat Model of Blast Polytrauma and Hemorrhagic Shock for Evaluating Innate Immunotherapies During Prolonged Damage Control Resuscitation. | <h4>Background</h4>A major challenge in developing effective immunological damage-control therapies for traumatic hemorrhage (TH) is the lack of animal models that accurately reproduce the immune and pathophysiological responses observed in humans. In this study, we established a clinically relevant rat model that comb... |
41677525 | Piezochromic Nanomaterials: Fundamental Mechanisms, Advances, Applications, and Future Prospects in Solar Cell Engineering. | Piezochromic nanomaterials, whose optical responses can be reversibly tuned by mechanical stimuli, have recently gained prominence as versatile platforms for strain-programmable light-matter interactions. Their mechanically responsive band structures, excitonic states, and defect energetics have enabled a wide range of... |
41675221 | Mitochondria-targeted delivery strategies for age-related diseases. | Aging is a complex progress accompanied with the progressive deterioration of physiological functions and a marked elevation in mortality risk. Among prominent aging theories, the free radical theory and the mitochondrial dysfunction hypothesis have gained significant attention. Thus, targeted delivery of therapeutic d... |
41674014 | Entropic Control of the Helicity Inversion Rates of Twisted Metallomacrocycles by Reversible and Regioselective Deprotonation. | The rate of molecular motion has been enthalpically controlled by external stimuli such as acids and bases, electrons, and light. However, controlling the rate of molecular motion through activation entropy remains a challenging task. Here, we report entropic control of the helicity inversion rate of a trinuclear Pd<su... |
41657650 | A mechanochemical route to triazatrinaphthylenes: building blocks for π-extended, nitrogen-enriched two-dimensional metal-organic frameworks. | Nitrogen-containing polyaromatic heterocycles are the key molecular materials in semiconducting and optoelectronic devices, yet their synthesis typically depends on high-boiling, toxic organic solvents and multi-step catalytic processes. Herein, we report a metal-free solid-state synthetic strategy followed by thermal ... |
41653633 | Sport improves function of roosters testicular Leydig cells by mediating FUNDC1. | Roosters play a crucial role in breeder chicken production. A decline in reproductive performance during the late breeding stage is a major factor limiting economic returns. Testosterone, a key hormone for maintaining secondary sexual characteristics and supporting spermatogenesis, is primarily synthesized and processe... |
41653631 | miRNA profiling reveals that gga-let-7i/COL1A2 axis induces cell cycle arrest and triggers cellular senescence to accelerate ovarian aging in laying hens by suppressing the PI3K/AKT/MDM2 pathway. | Reproductive senescence in laying hens, characterized by a progressive decline in egg production, represents a major challenge for the poultry industry. Although microRNAs (miRNAs) are recognized as important regulators of aging, their specific roles and mechanisms in ovarian aging of hens remain largely unclear. This ... |
41637789 | Antimicrobial resistance and genomic characteristics of avian Pasteurella multocida. | <h4>Background</h4>Pasteurella multocida, the cause of fowl cholera, poses a significant economic threat to poultry. The escalation of antimicrobial resistance (AMR) in this pathogen, driven by drug misuse, is a serious concern. Crucially, a comprehensive understanding of AMR patterns, molecular epidemiology, and virul... |
41635912 | Carbon-iodine atropisomerism on triazole and triazolium frameworks: a breathing axle with divergent adaptivity. | Atropisomerism around a carbon-iodine(iii) bond represents a rare form of chirality centered on a long, polarizable hypervalent linkage. Embedding this C-I(iii) bond into an inherently asymmetric, diadamantylated triazole scaffold creates a vivid platform that reveals how such a bond responds to steric and electronic p... |
41635435 | Screwing the helical chirality through terminal <i>peri</i>-functionalization. | Helical chirality is an important, but underrated form of chirality than other types of chirality. Molecules with helical chirality impart a crucial role in several biological phenomena as well as in modern materials applications. Classically, the generation of chiral helicity in organic molecules relies on a ring exte... |
41633077 | The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. | The H7N9 subtype of avian influenza virus (AIV) poses a significant and ongoing threat to public health. As a critical structural and functional component, the viral nucleoprotein (NP) is abundantly expressed during the early stages of AIV replication; however, its interactions with host proteins and their functional c... |
41632991 | Supramolecularly co-assembled composite bone cement prepared from tea polyphenol-modified tricalcium phosphate/tricalcium silicate with osteogenic, antibacterial, and immunomodulatory effects. | Injectable bone cements are widely applied in orthopedic repair, yet their effectiveness is limited by inadequate immune modulation and antimicrobial activity. Here, we developed a multifunctional bone cement (TTKS) by modifying tricalcium phosphate (TP-TCP, TTK) with tea polyphenols (TP) through supramolecular co-asse... |
41607058 | Highly Efficient Deep-Blue Room-Temperature Phosphorescence With Tunable Long-Lived Afterglow and Reversible Photoactivation Behavior. | Wide band gap organic molecule with ultralong room-temperature phosphorescence (RTP) remains a big challenge in optoelectronic field due to the intrinsic large Stokes shift of phosphorescence relative to fluorescence, and complexity of filling and stabilizing high-energy triplet excited states. In this work, three orga... |
41605609 | Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives. | We report an enantioselective copper-catalyzed amino oxygenation of alkenes, enabling direct access to chiral β-alkylamino lactones in up to 96% yield and 99% ee. In contrast to previous methods that introduced protected forms of amines, this method allows for the direct installation of electron-rich alkylamines throug... |
41605929 | Synergistic MOF-based composite enabling significant solar-to-water generation enhancement in climate-resilient AWH. | Solar-driven atmospheric water harvesting (SAWH) holds significant promise for decentralized water supply. However, its widespread application is hindered by two critical limitations: underutilization of high-humidity adsorption windows during nighttime and insufficient desorption during daytime due to the high desorpt... |
41606809 | The Metal Coordination Effects on the Optoelectronic Properties of Perylene Diimide and Nucleotide Supramolecular Complex (GMP:PDI: Ag(I)/Co(II)/Zn(II)): Computational and Experimental Studies. | In this comprehensive investigation, we present an integrated computational and experimental study of a series of metal-doped supramolecular PDI(β-ala)-GMP complexes using Ag(I)/Co(II)/Zn(II) as central metal ions. The supramolecular assemblies were critically analyzed in terms of optoelectronic properties and electron... |
41606327 | Population-scale sequencing resolves determinants of persistent EBV DNA. | Epstein-Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence f... |
41605863 | Pharmacokinetic Optimization of Radiocopper-Based Theranostic Pretargeting. | In vivo pretargeting offers a strategy to improve nuclear imaging and radiopharmaceutical therapy by increasing tumor-to-background activity concentration ratios and decreasing radiation burden to healthy tissues. One particularly promising approach to in vivo pretargeting is predicated on the inverse electron-demand D... |
41605137 | Enhancement and Sensing Performance of Ultra-Narrowband Induced Circular Dichroism in Achiral Nanohole Arrays Based on Bound States in the Continuum. | Chiral micro- and nanostructures exhibit strong circular dichroism (CD), demonstrating significant research and engineering potential in chiral molecular recognition, negative refraction material design, and polarization-selective imaging techniques. However, designing chiral structures with powerful CD, extremely narr... |
41606435 | Submicron Size C@TiO<sub>2</sub> with Multiple Resonance Effects for Surface-Enhanced Raman Spectroscopy and Photocatalysis. | Semiconductor materials are biocompatible and stable and have excellent controllable properties; nevertheless, their low sensitivity and enhancement factor limit their application and development in the field of surface-enhanced Raman scattering (SERS). Herein and for the first time, noble-metal-free submicrometer C@Ti... |
41605132 | Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles. | Tumors often exhibit an extracellular matrix with elevated stiffness due to excessive accumulation and cross-linking of proteins, particularly collagen. This elevated stiffness acts as a physical barrier, impeding the infiltration of immune cells and the effective delivery of various immunotherapeutic agents, such as l... |
41606438 | Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi-π 1,5-Enynes in a Copper-Catalyzed Cascade to Indenes. | C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an abundant solvent into carbon building blocks. A major challenge, however, is to direct the highly reactive benzyl radical to add regioselectively to a multi-π system in a way that initiates a cascade leading to complex produ... |
41605509 | Electron Transfer Mechanism-Mediated Host-Guest Nanoswitch Powered Amplification-Free CRISPR/Cas12a-Electrochemiluminescence Bioassay for Alzheimer's Disease Diagnosis. | Developing a high-performance amplification-free electrochemiluminescence (ECL) assay platform that operates at a low trigger potential is a promising strategy for broadening the applications of ECL sensing. In this work, we present a host-guest interaction-mediated split-type CRISPR/Cas12a-ECL assay platform by using ... |
41605788 | Direct Arylation of Unactivated Arenes Using Earth-Abundant Iron/Tetra-Aza Macrocyclic Complexes. | Biaryl motifs are central in pharmaceutical drug design, yet conventional synthesis via palladium-catalyzed cross-coupling poses increasing sustainability and cost concerns. The study presented herein explores a greener alternative to palladium using iron(II) complexes supported by tetra-aza macrocyclic ligands for dir... |
41606710 | Catalytic Amyloids: Turning Fibrils Into Biocatalysts. | Amyloids have been regarded as the pathological entities behind neurodegenerative diseases for a long time. The discovery that they also play physiological roles together with their ability to form stable and ordered scaffolds opened the door for their applications in different fields. In this context, catalytic amyloi... |
41606026 | Identification of bacterial key genes and therapeutic targets in hypertensive patients with type 2 diabetes through bioinformatics analysis. | Hypertension (HTN) coexisting with type 2 diabetes (T2D) significantly increases cardiovascular risk, yet most microbiome studies have focused on these diseases separately and have overlooked their combined microbial gene-level mechanisms. The coexistence of HTN and T2D may create a distinct gut microbial environment w... |
41607014 | Simultaneous Boost of SF<sub>6</sub> Adsorption Capacity and Kinetics Through Isoreticular Functionalization of Zinc(II)-Pyrazolate Frameworks. | The capture of sulfur hexafluoride (SF<sub>6</sub>), the most potent greenhouse gas, is of critical importance. Enhancement of dynamic SF<sub>6</sub> capture capacity presents significant challenges due to its chemical inertness and low concentration in industrial effluent streams. Herein, we demonstrate that the isore... |
41607021 | Proton-Activated Artificial Channels for pH-Selective Cancer Therapy. | Proton-activated ion channels mediate ion transport in response to extracellular acidification, enabling cellular adaptation to acidic microenvironments. Despite their biological importance, mimicking proton-activated functionality in artificial ion channels remains a significant challenge. Here, we present a novel cla... |
41606261 | Glycolipid recognition and binding by Siglec-6 hinges on interactions with the cell membrane. | Sialic acid-binding immunoglobulin-type lectins (Siglecs) regulate immune response through interactions with sialylated glycans on glycoproteins and glycolipids. Human Siglecs count 14 unique proteins and in all of those the recognition and binding of the sialic acid on the glycan target involves a conserved, or canoni... |
41605949 | Allylrhodanine-processed all-small-molecule organic solar cell achieves an 18.43% efficiency breakthrough. | Solid additives (SAs) improve organic solar cells (OSCs) morphology and performance, yet, their efficiency in all-small-molecule (ASM) OSCs is limited by strong donor-acceptor crystallinity, and the underlying mechanisms remain unclear. Herein, structurally resembling the MPhS-C2 donor, 3-allylrhodanine (3-AR) as a SA ... |
41605953 | Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies. | Coronaviruses remain a challenge due to the limited or incomplete protection provided by existing vaccines, highlighting the need for improved antigen-based designs that can reduce mortality, block transmission, and provide long-lasting, broad-spectrum protection. In this study, we adapted artificial antibody strategie... |
41607179 | Symmetric Metal Organic Framework-Plasmonic Architectures for Reversible and High-Sensitivity Optical Sensing. | Plasmonic nanostructures have attracted considerable interest for their ability to manipulate light at the nanoscale. The optical response of these metallic architectures is greatly sensitive to changes in their surrounding environment, which makes them particularly interesting for sensing applications. Here, we report... |
41605245 | Spatially Confined Self-Assembly of Plasmonic Trimer Nanogaps for High-Contrast Tumor Boundary Delineation. | Conventional plasmonic nanogap assemblies face a major challenge in biological applications due to their lack of cellular specificity, often leading to off-tumor assembly and false signals in normal cells. To overcome this limitation, we developed an endogenous dual-input-activated strategy for spatially confined intra... |
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