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41606949 | Self-Healing Antibacterial Metallosupramolecular Soft-Networks: Comparative Studies on Mechanical Flexibility and Semiconducting Device Applications. | Mn(II)/Ni(II)-salts and 2,5-pyridinedicarboxylic acid (PDA)-based individual supramolecular metallogels (i.e., Mn-PDA and Ni-PDA) are achieved by maintaining specific stoichiometric ratios of distinct metal salts and PDA (i.e., 1:1). 2,5-Pyridinedicarboxylic acid acts as a low-molecular-weight organogelator, and <i>N</... |
41607004 | Graph Neural Networks for Polymer Characterization and Property Prediction: Opportunities and Challenges. | Using machine learning to accelerate the characterization and prediction of properties of many-molecule systems, such as polymers, is appealing, yet challenging. Polymers are large, complex molecules that have unique properties and potential applications in a wide range of industries. Their potential in advancing field... |
41606950 | Data-Integrated Elucidation of Structure-Activity Relationships toward the Rational Design of Perfluoroiodoarene-Based Halogen-Bond Donor Catalysts. | Understanding and predicting catalyst performance from structural and electronic information remains a central challenge in organocatalysis. Here, we present a data-integrated framework that quantitatively combines experimental, computational, and machine learning (ML) approaches to elucidate the structure-activity rel... |
41606113 | Development of a carbon fiber-based microextraction sample preparation patch for the detection of 21 organochlorine pesticides from water. | The widespread use of organochlorine pesticides (OCPs) in agricultural practices has led to its accumulation in water bodies, causing significant environmental and health risks due to its persistence and toxicity. To enable effective monitoring, carbon fiber-based thin-film solid-phase microextraction (TF-SPME) patch w... |
41605944 | Ultralong-range exciton transport in submillimeter-scale spherulite film of π-conjugated polymers. | Long-range exciton transport in organic semiconductors is essential for the performance of optoelectronic devices. However, solution-processed π-conjugated polymers films typically exhibit short exciton diffusion lengths (<20 nm) due to local imperfections or variations in interchain packing. Here, large-area submillim... |
41605808 | Improved Catalytic Fenton-Like Degradation of Methyl Violet Dye at Neutral pH Using the Encapsulated Tris(acetylacetonato) Iron(III) Complex inside the Zeolitic Imidazolate Framework-8. | In this work, a new catalyst with high Fenton-like behavior was synthesized by heterogenizing the inexpensive tris(acetylacetonato)iron(III) complex (Fe(acac)<sub>3</sub>) into the micropores of ZIF-8 through the facile bottle-around-the-ship approach, which is the first example of encapsulating iron complexes in ZIF-8... |
41625477 | Tumor Microenvironment Onmyoji: Cytokines with Dual Protumor and Antitumor Roles. | Cytokines are essential components of the tumor microenvironment (TME) and play crucial roles in tumor initiation and progression. As key mediators of interactions between immune cells and tumor cells within the TME, many cytokines exhibit both protumor and antitumor properties. This complex duality, reminiscent of the... |
41625274 | Recent Progressions in Applications of Bioactive Polysaccharides in Food and Health Sciences: A Comprehensive Review. | Nowadays, the incidence and mortality rates of diseases remain major challenges throughout the world. To stop these health-threatening concerns, a safe diet plays a pivotal role. Polysaccharides, as natural biopolymers, possess remarkable potential in the development of safe and healthy foods to prevent the incidence o... |
41624340 | Versatile Metal Phthalocyanine-Based Memristive Nanowire Network: Unraveling the Dynamics of Digital to Analog Switching. | Organic memristors with tunable resistive switching (RS) are promising candidates for brain-inspired neuromorphic computing. This study reports a self-assembled organic nanowire network memristor based on copper (II) hexadecafluoro-phthalocyanine (F<sub>16</sub>CuPc), exhibiting digital, multilevel, and analog switchin... |
41623380 | Battling biofilms: evaluating selected agents against <i>Cutibacterium acnes</i>-a review. | <h4>Background</h4><i>Cutibacterium acnes (C. acnes)</i> is a causative agent in the development of acne vulgaris, and this bacteria has been reported to show resistance against conventional antibiotics. One of the vital factors contributing to antibiotic resistance is the ability of <i>C. acnes</i> to form biofilms. T... |
41605955 | Cycling molecular assemblies for Golgi imaging and disruption. | The Golgi apparatus is a central hub for protein trafficking and signaling, yet its rapid imaging and cell-selective disruption remain challenging. Here, we report cycling molecular assemblies (CyMA) for fast Golgi imaging and cell-selective interference. CyMA precursors are acetylated amphiphilic thiopeptides that tra... |
41621335 | Duck β-defensin 10 inhibits Salmonella enterica by disrupting bacterial membrane integrity and its association with gut microbiota dynamics. | Salmonella infections pose a significant threat to waterfowl. Avian β-defensin 10 (AvBD10), a key molecule of host innate immunity, exhibits broad-spectrum antibacterial activity and immune regulatory function. However, research on the tissue-specific expression and antibacterial activity against Salmonella of AvBD10 i... |
41621331 | Development of monoclonal antibodies for GoAstV-2 VP27 protein and precise mapping of linear antigenic epitopes. | Since 2016, a novel astrovirus identified as goose astrovirus (GoAstV), is classified into genotypes 1 and 2 (GoAstV-1 and GoAstV-2). GoAstV-2 has caused a severe outbreak of visceral gout in goslings characterized by extensive visceral urate deposition and kidney swelling, resulting in substantial financial losses to ... |
41619585 | Multifunctional Fluorescent Probes for Chemical Warfare Agents Phosgene and Sarin Simulant: Heteroatom Engineering-Driven Performance Enhancement. | Multifunctional fluorescent probes targeting chemical warfare agents have been highly valued due to high-detection efficiency and cost-effectiveness, but sluggish development and inadequate performance remain imminent. Exploiting innovative design strategies is the most effective program to achieve performance breakthr... |
41619327 | Eu-MOF@Ce-MOF heterostructure and molecularly imprinted polymer composite system for SARS-CoV-2 point-of-care detection. | Metal-organic frameworks (MOFs) have attracted growing interest as advanced sensing materials due to their structural tunability and functional versatility. The responsiveness of MOF-based sensors is typically governed by changes in either the metal centers or organic linkers, making it essential to engineer novel arch... |
41616498 | Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review. | Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants' clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the b... |
41605899 | Spin-canted Mn-Mn coupling in symmetry-broken metal chloride dimer with dual-responsive luminescence and sensing. | Magneto-optical coupling provides a powerful alternative to crystal field engineering for modulating Mn<sup>2+</sup> luminescence. However, precise control over Mn-Mn coupling is hindered by the complex spin-electron super-exchange interactions. Herein, we report a symmetry-broken Mn(II) chloride dimer, (C<sub>10</sub>... |
41614206 | Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions. | Natural products, originating from diverse biological sources, serve as a critical reservoir of bioactive compounds for cancer intervention across prevention, treatment, and supportive care. Their mechanisms extend beyond direct cytotoxicity to include modulation of tumor metabolism-such as glucose, lipid, and glutamin... |
41613238 | Combined mass spectrometry and computational analysis of cyanine dyes and their structural analogues. | Cyanine dyes are widely used in biological imaging and labelling, yet the influence of halide counterions on their gas-phase stability and fragmentation remains poorly understood. Here we report a combined high-resolution mass spectrometry and computational study of asymmetric monomethine cyanine dyes bearing one to fo... |
41613236 | Nickel-containing 4,4'-biphenol mixed-mode stationary phase for the separation of polyaromatic compounds, benzene derivatives and nucleotides. | A new mixed-mode hybrid stationary phase is synthesized, followed by its characterization using BET analysis, SEM, FTIR spectroscopy and EDX analysis. 4, 4'-Biphenol was esterified using ethyl chloroacetate in the presence of potassium carbonate, followed by carboxylation using ethanol/water (9 : 1 v/v%) in the presenc... |
41613224 | Chemical reactivity of 2-methylchromone with some nitrogen-based nucleophiles: reactions, DFT analysis, anticancer activity and molecular docking studies. | The current study investigates the reactivity of 2-methylchromone toward nitrogen-containing heterocyclic amines, with the aim of assessing how substitution pattern and nucleophile type influence chromone ring opening and subsequent heterocycle formation. Reaction of 2-methylchromone (1) with selected heterocyclic amin... |
41613230 | Molecular and materials design for efficient solar energy conversion: a review of photochemical technologies. | The inexorable rise in global energy demand, coupled with the pressing imperative to mitigate anthropogenic climate change, has catalyzed unprecedented research effort into renewable energy sources. Photochemistry, the study of chemical reactions initiated by light, is fundamentally shaping this landscape, particularly... |
41613229 | Engineering ofloxacin bioavailability through spray-dried HPMC and xanthan gum-based solid dispersions: enhanced solubility and therapeutic efficacy. | This study explores the enhancement of oral bioavailability, dissolution rate, and solubility of weakly water-soluble fluoroquinolone antibiotic, ofloxacin (OFL), by solid dispersion (SD) formulation prepared using the spray drying technique. Hydrophilic polymers; hydroxypropyl methylcellulose (HPMC) and xanthan gum (X... |
41613223 | Effect of dopant concentration and ambient temperature on the pseudo-capacitance behavior of novel copper doped bismuth layered double hydroxide. | Supercapacitors made up of 2D heterostructures materials have revolutionized the industry of energy harvesting devices because of their distinct physical and chemical properties, superior cyclic stability, better coulombic efficiency, and higher energy density, along with the retention of higher power density. In this ... |
41613221 | Nanobiotechnology-driven advances in sonodynamic therapy: unlocking the potential of sonosensitizers in clinical translation. | Sonodynamic therapy (SDT) is an emerging, non-invasive modality to cancer treatment, notable for its ability to overcome the limited tissue penetration of photodynamic therapy (PDT) while delivering enhanced precision and reduced adverse effects. This distinctive advantage has positioned SDT as a highly compelling appr... |
41605923 | A water-soluble copolymer for storage and electron conversion in photocatalytic on-demand hydrogen evolution. | Cost- and energy-efficient long-term storage of excess solar energy remains a major bottleneck in the transition to a sustainable society. Here, we present a water-soluble redox-active copolymer containing viologen moieties that can be charged with electrons upon visible light irradiation using a tris[4,4'-bis(tert-but... |
41604702 | Microfluidic Encapsulation of Sorafenib-Loaded ZIF-8 Nanoparticles in pH-Responsive Alginate Microparticles for Oral Chemotherapy of Hepatocellular Carcinoma. | Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality. Sorafenib is the current first-line oral therapy; however, its therapeutic efficacy is limited by poor aqueous solubility, low bioavailability, and gastrointestinal instability. This study aimed to develop a pH-responsive nano... |
41604692 | Paired Agent Imaging to Evaluate the Improvement of Affinity-Matured Nimotuzumab K4 and K5 Variants as EGFR-Detecting Optical Imaging Agents. | Molecular imaging is a useful tool for the <i>in vivo</i> validation of antibody therapeutics. It shows the accumulation properties of antibodies in tumors and organs that cannot be predicted by using <i>in vitro</i> assays. Two issues with characterizing antibodies using <i>in vivo</i> imaging are: (i) the fluorescent... |
41604688 | Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles. | Understanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of interdependent parameters involved, such as particle size, aggregation number, interfacial curvatu... |
41604679 | An Acid-Resistant Hf<sub>6</sub>-MOF for the Luminescence Sensing of Biomarkers with High Sensitivity and Selectivity. | Although the detection of biomarkers epinephrine (EP) and homovanillic acid (HO) is critical for early diagnosis and personalized medicine, the development of a luminescent sensor for their precise quantification remains an ongoing challenge. In this work, a unique porous Hf<sub>6</sub>-based metal-organic framework (M... |
41604593 | Physics-Embedded Neural Network: A Novel Approach to Design Polymeric Materials. | Designing and developing high-performance polymeric materials with machine learning has become a major trend in materials science. However, conventional data-driven neural network models often suffer from the "black-box" problem, lacking physical constraints and interpretability, and struggle to achieve accurate predic... |
41604590 | Dual Confinement-Enhanced Multiple Single Nucleotide Variant Detection at the Single-Particle Level. | The efficacy of multiple single nucleotide variants (SNVs) analysis is far from ideal due to the limitations in identification. This study introduced a novel strategy for multiple SNVs analysis at the single particle level, integrating molecular and nanomaterial confinement to significantly accelerate the kinetics of m... |
41604587 | Nanozyme Microrobots: Programmable Spatiotemporal Catalysis for Targeted Therapy and Diagnostics. | Nanozyme microrobots combine catalytic nanomaterials with small-scale robotic control to deliver programmable, spatiotemporal catalysis for biomedical applications with precision. Actuated by external stimuli, such as magnetic, acoustic, optical, or chemical gradients, these systems localize and modulate catalytic acti... |
41604584 | Asymmetric Cu─N─Ru Bridgedsite Nanozyme-Loaded Injectable Thermogel Boosts Cuproptosis-Like Death for Multidrug-Resistant Urinary Tract Infections. | Multidrug-resistant urinary tract infections (MDR-UTIs) remain one of the most challenging clinical infections globally owing to the paucity of effective therapeutic agents. Nanozymes-triggered cuproptosis-like bacterial death has emerged as a promising bactericidal strategy. However, its efficacy is compromised by ins... |
41604579 | Chaperone-Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction. | Excessive macrophage-mediated inflammation following myocardial infarction (MI) exacerbates infarct expansion and impairs cardiac repair; however, the regulatory mechanisms remain poorly understood. Here, it is reported that ubiquitin-specific peptidase 9 X-linked (USP9X) was significantly downregulated in macrophages ... |
41604549 | Nanozymes for Energy and Environmental Sustainability. | Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability. Their enzyme-like catalytic activity, combined with exceptional chemical stability, low cost, and structural tunability, enables them to function effectively in harsh operational conditions where natura... |
41604491 | In situ anchoring 2D hexagonal Zn-MOF on MXene toward robust anode-less 5 V-class Li metal batteries. | Anode-less 5 V-class lithium metal batteries (LMBs) promise high energy density and safety yet, in practice, face critical challenges including dendrite growth, interfacial instability, pulverization associated with "dead" lithium accumulation, and energy density compromise from the use of heavy copper collector. Here,... |
41604475 | CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation. | The sperm flagellar-specific CatSper Ca<sup>2+</sup> channel is a multiprotein complex critical for successful fertilization. The four ancillary subunits, CATSPERβ, γ, δ, and ε, form a unique canopy structure over the pore-forming channel. However, how the canopy is formed and what it does in the assembled channel comp... |
41604460 | The Complexation Properties of Self-Defensive Microgel-Modified Antimicrobial Surfaces. | The complexation of cationic antimicrobials with polyanionic microgels on a biomaterial surface can render that surface self-defensive against bacteria by killing those bacteria which physically contact the antimicrobial-loaded microgels. This killing has been attributed to the contact-driven transfer of antimicrobial ... |
41604452 | Allosteric effects of the coupling cation in melibiose transporter MelB. | The major facilitator superfamily (MFS) transporters play significant roles in human health and disease. <i>Salmonella enterica</i> serovar Typhimurium melibiose permease (MelB<sub>St</sub>) catalyzes the symport of galactosides with Na<sup>+</sup>, H<sup>+</sup>, or Li<sup>+</sup> and is a prototype of MFS transporter... |
41604266 | Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication. | Emerging and reemerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant viral variants. Hence, there is an urgent need for additional broad spectrum antiviral therapeutic strategies. Here, we ide... |
41604264 | Elucidating chiral myosin-induced actin dynamics: From single-filament behavior to collective structures. | The myosin superfamily encompasses over 70 classes, each with multiple subclasses, and exhibits substantial diversity in properties such as velocity, ATPase activity, duty ratio, and directionality. This functional diversity enables the specialized roles of each myosin in various organisms, organs, and cell types. Beyo... |
41604247 | Cryo-EM structure revealed a novel F-actin binding motif in a <i>Legionella pneumophila</i> lysine fatty acyltransferase. | <i>Legionella pneumophila</i> is an opportunistic bacterial pathogen that causes Legionnaires' disease. To establish an intracellular niche conducive to replication, <i>L. pneumophila</i> translocates a diverse array of effector proteins that manipulate various host cellular processes, including the actin cytoskeleton.... |
41604096 | Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs. | Antibiotic resistance (ABR) is a leading cause of death and a major public health threat globally. Without appropriate interventions, annual ABR-associated deaths have been projected to reach 10 million by 2050 worldwide. Hence, it is critical to develop novel therapeutic interventions that would be able to tackle ABR ... |
41604094 | Eco-friendly silver nanoparticles from neem extracts: a dual approach to heavy metal sensing and antimicrobial applications. | This work investigates the green synthesis of silver nanoparticles (AgNPs) using mixed aqueous extracts of Azadirachta indica leaves and roots as natural reducing and stabilizing agents. The synthesis was optimized by varying extract concentration, pH, and temperature, and nanoparticle formation was confirmed by UV-Vis... |
41604050 | The Influence of Substituents on 4-Amino-1,2,4-Triazole Luminescence: A Combined Crystallographic and Spectroscopic Study. | To explore new luminescent materials, two novel luminescent salts, [HAD]⁺BSA⁻∙methanol (1) and [HAD]⁺TSA⁻∙methanol (2), incorporating the 4-amino-1,2,4-triazole functional moiety (AD = 4,4'-(4-amino-4H-1,2,4-triazole-3,5-diyl)dianiline), were successfully synthesized through reactions with benzenesulfonic acid and p-to... |
41604053 | Enhancing bone repair ability of 3D-printed PLLA scaffolds via N-methyl-2-pyrrolidone etching. | The development of bone repair scaffolds has long been a research hotspot in tissue engineering. Owing to its unique capability for personalized customization of scaffold geometry and microstructure, 3D printing technology has been extensively adopted for fabricating bone repair scaffolds. Poly-L-lactic acid (PLLA), en... |
41604024 | Machine learning-driven exosome-mimetic lipid nanoparticles for tumor-specific targeting. | Exosome-mimetic lipid nanoparticles (ENPs) are a promising alternative to PEGylated lipid nanoparticles (LNPs) for targeted cancer therapy, offering improved biocompatibility and reduced immune clearance. However, the rational design of these biomimetic particles is challenging due to complex lipid composition requirem... |
41603739 | A supramolecular assembly of cone-specific G-protein and cryptochrome 4a on lipid bilayer. | Signal transduction processes often involve membrane-associated proteins allowing facilitated diffusion of reactive partners in a phospholipid bilayer plane. A benchmark example is phototransduction, taking place at the disk membranes of vertebrate rod and cone outer segments. Long-wavelength sensitive cones in night m... |
41603574 | AIE-Active Tetrazolyl Tetraphenylethylene-Based Metal-Organic Framework as Highly Selective Chemosensor for Nitro Explosives. | The development of fast and sensitive fluorescence sensors for nitro-explosive detection in aqueous environments remains a critical challenge for security and environmental monitoring. This work presents two novel metal-organic frameworks (MOFs) constructed from tetrakistetrazole-functionalized tetraphenylethylene (H<s... |
41603560 | Fracture Probability is Predictive of Fall-Associated Hospitalization: The Manitoba BMD Registry. | The current version of FRAX® does not consider prior falls as a primary input variable. Limited data suggest that greater FRAX-derived fracture probability is associated with incident falls at least in elderly men. Our aim was to examine the association of FRAX-derived fracture probability with the risk for subsequent ... |
41603494 | Mistletoe- and Mussel-Inspired Fabrication of Hierarchically Structured Protein-Cellulose Scaffolds From Biomolecular Condensates. | Nature's ability to produce hierarchical materials via biomolecular self-assembly can inspire bioinspired avenues to advanced materials using biorenewable components and water as a solvent. Recent advances indicate that biomolecular condensates are important precursor phases for fabricating biological materials. Here, ... |
41603451 | High-Modulus and High-Damping Ionic Polymers Enabled by Cohesive Entanglement. | High-modulus polymers typically derive their properties from high crosslinking density and strong intermolecular interactions. In contrast, high-damping polymers primarily dissipate energy via the sliding and friction of mobile molecular segments. This fundamental contradiction creates an inherent trade-off, rendering ... |
41603442 | Double-Cyclized Dipeptides for Hierarchical Self-Assembly Into Crystalline Macroscopic Superhelices. | Cyclic peptides have attracted significant attentiondue to their persistent structures and particular biological effects, which are also key building blocks for creating functional chiral materials. Here, we report a double-cyclized dipeptide structure-a macrocycle embedded with a cyclic dipeptide-and its use in constr... |
41603397 | Rational design of organometallic therapeutics: leveraging metal-metal bonds for biomedical innovation. | Metal-metal interactions play a crucial role in determining the molecular geometry, stability, and biological activity of many compounds. In recent years, organometallic compounds have gained significant importance in medicinal chemistry due to their structural and functional properties in treating various ailments. A ... |
41603369 | Identifying regulators of associative learning using a protein-labelling approach in <i>Caenorhabditis elegans</i>. | The ability to learn and form memories is critical for animals to make choices that promote their survival. The biological processes underlying learning and memory are mediated by a variety of genes in the nervous system, acting at specific times during memory encoding, consolidation, and retrieval. Many studies have u... |
41603248 | Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy. | Biomimetic membrane interface engineering constructs functionalized detection platforms by incorporating natural cell membranes, synthetic lipids, or hybrid membranes. The primary purpose of this strategy is to minimize background interference while leveraging intrinsic membrane properties for effective target interact... |
41603232 | Sugar-Armored Pesticides: Self-Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases. | Naturally hydrophobic characteristics of most pesticides seriously affect their effective deposition and bioavailability on susceptible plants, causing inevitable off-target movement and environmental pollution. To solve this problem, we employ supramolecular self-assembly strategies to deliver and remedy such defectiv... |
41603224 | Competition Between Liquid-Liquid Crystalline Phase Separation (LLCPS) and Liquid-Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems. | Amyloid fibrils are rigid, elongated protein aggregates that form condensed phases in functional biological assemblies and pathological deposits. From a colloidal physics perspective, two separation pathways can lead to these condensed phases: liquid-liquid phase separation (LLPS), which results from a trade-off betwee... |
41603189 | Ultralow-Frequency Epsilon-Near-Zero States in 3D-Printed High-Entropy Alloy Metacomposites for Ultra-Thin Perfect RF Absorption. | Epsilon-near-zero (ENZ) materials with radio-frequency perfect absorption are pivotal for next-generation electromagnetic stealth, 5G (fifth-generation mobile networks) signal integrity, and IoT (internet of things) security. Here, 3D-printed metacomposites achieving low-frequency ultra-thin ENZ absorption (>90%, 55-11... |
41603131 | Synergistic Activation of Immunogenic Cell Death and the cGAS-STING Pathway by Engineered Zinc/Manganese-Based Metal-Organic Framework Nanoplatforms for Colon Cancer Immunotherapy. | The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway is crucial for tumor immunity. However, activation of the cGAS-STING pathway alone is seldom sufficient to eliminate established tumors. Here, we report the engineering of zinc/manganese (... |
41603099 | Advancing Single-Walled Carbon Nanotubes toward Next-Generation Electronic Materials: The Critical Roles of Purity and Processability. | Single-walled carbon nanotubes (SWNTs) have garnered significant attention due to their unique size- and structure-dependent properties, making them highly promising for a wide range of applications. Among these properties, their exceptional electrical conductivity positions them as potential alternatives to traditiona... |
41603117 | Medical Fabrics with Non-Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination. | Infections caused by bacterial colonization and biofilm formation on wounds and dressings present critical challenges to wound care, often impeding healing. Here, we report an antibiotic-free preventive strategy based on medical fabric coated with supramolecular antimicrobial assemblies. Using layer-by-layer dip coatin... |
41603122 | Modulation of MOF Energy State to Construct Smart Activated Sensitizers for Membrane Directed C-H Ketene Therapy in Tumor Cells. | Phospholipid oxidation closely links tumorigenesis to tumor microenvironment (TME) remodeling, easily producing lipid peroxides that cause inflammation and membrane damage. The inherent complexity and unpredictable biological effects of phospholipid peroxidation necessitate precision catalytic platforms for selective a... |
41603089 | Stereospecific Assembly of Triply Chiral Pseudopeptidic Cages Through Dynamic Dual Chirality Transfer. | A stereospecific transmission of chiral information within tripodal pseudopeptidic cages has been observed from dynamic constitutional co-operation of reversible orthogonal processes: imine bond and metal coordination. The chiral centers from the phenylalanine amino acid moieties induce a specific chirality into the fo... |
41603020 | Spatially and Dimensionally Programmed Amorphous Cu Electrocatalysts Using DNA Framework Templates. | The precise control of active site spatial structure is a central challenge in high-performance catalyst development and is particularly formidable in long-range disordered amorphous materials where inherent disorder prevents any deliberate engineering. Herein, we develop a DNA framework templated approach to program t... |
41601459 | Sustainable Continuous Scale Synthesis of Positive Material for High-performance Wearable Aqueous Zn Metal Batteries. | One factor limiting the development of wearable, aqueous zinc metal batteries has been the inability to continuously synthesize high-performance positive electrodes quickly, efficiently, and sustainably. In this work, a continuous and scalable synthesis of high-performance positive electrodes at room temperature by sit... |
41601439 | Hybrid Nanofibers for Multimodal Accelerated Wound Healing. | Wound healing is a complex physiological process that demands multifunctional therapeutic approaches to ensure effective recovery. This study presents a straightforward approach using blend electrospinning to produce multimodal hybrid nanomaterials that accelerate the wound healing process. Poly(L-lactide-co-ε-caprolac... |
41601431 | Toward Dynamic Liquid Cell Scaffold: Photoreversible Ion Gels Exhibiting Light-Induced Sol-Gel Transitions. | Reversible sol-gel transitions are difficult to achieve in conventional water-swollen hydrogels in open aqueous environments, because polymer chains dissolve or diffuse once the network disassembles. Here, we present a proof-of-concept to overcome this limitation by introducing a water-immiscible and non-cytotoxic ioni... |
41601305 | Multi-Modal Fusion Frameworks of Subgraph-Optimized Graph Autoencoder for Molecular Property Prediction. | Molecular property prediction refers to predicting the properties of a given molecular representation. This task is of great significance in fields such as drug design and has garnered widespread attention from researchers. For molecular property prediction, the quality of feature learning plays a decisive role in mode... |
41593739 | LSD1 maintains oocyte quality by epigenetically repressing CAMK2β to control granulosa cell-oocyte communication. | <h4>Background</h4>Poor ovarian response (POR) is a major challenge in assisted reproduction, yet its molecular basis remains poorly understood. Communication between granulosa cells (GCs) and oocytes is critical for folliculogenesis, but how it is regulated epigenetically is unclear.<h4>Methods</h4>We generated granul... |
41593306 | Single-immunocyte transcriptomics reveal the role of natural killer cell-dependent exogenous antigen presentation in ankylosing spondylitis severity. | Ankylosing spondylitis (AS) is an autoimmune disease that can cause severe deformities, and the immunological patterns associated with its onset and progression remain poorly understood. Here, after recruiting healthy donors and patients in different stages, we performed single-cell RNA sequencing for peripheral blood ... |
41593047 | Sensitivity enhancement of surface plasmon resonance biosensors based on versatile nanostructures: principle, fabrication, and illustrative applications. | Surface plasmon resonance (SPR) biosensoris a new type of high sensitivity, real-time, label-free detection technology, which plays an increasingly important role in the biomedicine field. Considering the urgent requirement of trace detection, especially for diagnosing early-stage diseases, the demand for high detectio... |
41566643 | Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk. | Avian infectious bronchitis virus (IBV) belongs to the genus <i>Gammacoronavirus</i> (family <i>Coronaviridae</i>), causes severe multi-system disease in chickens, inflicting major global economic losses. The molecular interplay between IBV and host metabolic networks remains poorly understood. Through integrated trans... |
41529396 | Bioprinting collagenase-responsive hydrogel for controlled release of cowpea mosaic virus immunotherapy. | In this work, we developed a collagenase-responsive hydrogel system to covalently load cancer immunotherapy candidate cowpea mosaic virus (CPMV) using 3D digital light processing bioprinting technology. CPMV was functionalized with norbornene groups (CPMV-NB), which was then bioprinted into hydrogels with 8-arm polyeth... |
41528339 | Recognition mechanisms of multiple sclerosis antibody MS with antigens EBNA1 and GlialCAM <i>via</i> molecular dynamics simulations. | Multiple sclerosis (MS), a severe autoimmune disease of the central nervous system (CNS), is marked by detrimental demyelination and axonal destruction. High-affinity molecular mimicry exists between Epstein-Barr virus nuclear antigen 1 (EBNA1) and glial cell adhesion molecule (GlialCAM) in the CNS, leading to cross-re... |
41527871 | Insights into phonons and spin-lattice relaxation in copper(II) and vanadyl(IV) porphyrin metal-organic frameworks from density functional theory. | Employing metal-organic frameworks (MOFs) has been shown to be an effective strategy for extending spin-lattice relaxation times (<i>T</i><sub>1</sub>) by modifying the vibrational properties of molecular spin qubits. Although a previous study employed terahertz spectroscopy to probe vibrational properties, the specifi... |
41525708 | IAPP surface-induced aggregation and corilagin's inhibitory effect. | Proteins and peptides spontaneously assemble into various structured supramolecular entities that perform vital physiological functions. In pathology and biopharmaceutics, protein assemblies can form cytotoxic oligomers or protofibrils. Most studies focus on aggregation and inhibition processes in bulk solutions. Howev... |
41524379 | Visible-light-responsive supramolecular enzyme mimics for combating antimicrobial resistance. | The global rise of antimicrobial resistance has created an urgent need for alternative strategies that can overcome the limitations of conventional drug-resistance mechanisms. Light-assisted antimicrobial therapy, particularly photodynamic inactivation, offers spatial and temporal control while minimizing the likelihoo... |
41510688 | The iron-thiol-oxygen nexus for iron flux from bare and ferritin-caged minerals and safeguarding DNA: the impact of the thiol structure and protein coat. | The interplay between iron, sulfur, and oxygen underpins the redox regulation of iron across biological and geochemical systems. Prior to the great oxygenation event (GOE), sulfur fostered a reducing environment essential for Fe<sup>2+</sup> bioavailability. Post-GOE, the advent of the oxidative environment depleted ir... |
41502329 | Designing highly tunable laminin-inspired bioactive peptide hydrogel-based biomaterials for directing cellular response. | The extracellular matrix (ECM) plays a crucial role in regulating cellular interactions and cell signaling pathways through several biochemical cues. In this context, designing bioinspired ECM mimics, particularly supramolecular hydrogels derived from major ECM components, has gained great attention owing to their bioc... |
41937929 | A New Water-Soluble Copper(II) Coordination Polymer for Electrocatalytic Oxygen Evolution Reaction. | The development of efficient and low-cost catalysts to promote the oxygen evolution reaction (OER) is a challenge for the generation of green hydrogen through water splitting electrolysis. This work describes the synthesis of a new water-soluble one-dimensional copper-(II) coordination polymer for application as an ear... |
41908307 | Conceptualizing <i>in situ</i> energy station for Mars exploration. | This perspective underscores Martian air as the working medium for the space nuclear system integrated with heat-to-electricity and chemical conversion, paving the way for multimodal resource transformation on Mars. |
41783127 | Synergizing Chemical and AI Communities for Advancing Laboratories of the Future. | The development of automated experimental facilities and the digitization of experimental data have introduced numerous opportunities to radically advance chemical laboratories. As many laboratory tasks involve predicting and understanding previously unknown chemical relationships, machine learning (ML) approaches trai... |
41755878 | Thiolated Bis-<i>meta</i>-Carborane: A Molecular Rotor with Conformation-Dependent Dipole Moment. | The robust structure and tunable properties of 12-vertex carborane clusters make them highly attractive constituents of 2D and 3D self-assembled materials as well as for various potential applications. These molecules offer new possibilities related to their characteristic features such as low conformational freedom, h... |
41754912 | Polynuclear Silver(I)-Quinoxaline Complex: Comprehensive Structural Characterization, Antimycobacterial Properties and DNA/BSA Binding Study. | <b>Background</b>: Silver(I) complexes with aromatic heterocyclic ligands are well known for their broad antimicrobial potential, largely attributed to their ability to interact with biomolecular targets. <b>Results and Discussion</b>: In this study, a new polynuclear silver(I) complex with <i>N</i>-(3'-phenylpropyl)qu... |
41754911 | Inhalation-Based Nanoparticle Drug Delivery Targeting the Diseased Lower Airways in Idiopathic Pulmonary Fibrosis. | Initiated in the lower airways, idiopathic pulmonary fibrosis (IPF) is a fatal disease that disrupts the lung's functional architecture, for which therapeutics are of limited efficacy; consequently, the disease is progressive and incurable. New therapeutic approaches providing delivery of mechanism-modifying drugs dire... |
41751522 | DDX10 RNA Helicase: Structure, Function, and Oncogenic Roles Across Solid and Hematologic Tumors. | DEAD-box (DDX) RNA helicases are essential regulators of RNA metabolism and gene expression. Among them, DDX10 remains poorly characterized despite growing evidence supporting its involvement in human diseases. This review provides a comprehensive analysis of DDX10, from its structural and functional features to its em... |
41750425 | Design, Synthesis, Spectral, Structural Analysis, and Biological Evaluation of Novel Pyrazole Derivatives as Anti-Tumor, Antimicrobial, and Anti-Biofilm Agents. | <b>Objective:</b> Based on our previous findings, we designed new molecules by extending functionalized pyrazole derivatives containing iodine atoms, which are linked via an amino bond to halogen-substituted phenyl groups. In addition, these newly developed pyrazole compounds exhibit anti-tumor, antibacterial, and anti... |
41750267 | Bioinformatics-Driven, Plant-Based Antibiotic Research Against Quorum Sensing and Biofilm Formation in <i>Pseudomonas aeruginosa</i> and <i>Escherichia coli</i> Multiresistant Microbes. | Quorum-sensing (QS) systems play a crucial role in regulating virulence, biofilm formation, and antibiotic resistance in clinically relevant microbes. This review explores the potential of QS systems as targets for developing novel plant-based therapeutic strategies using bioinformatics, aimed at combating highly patho... |
41746044 | Dose-Dependent Efficacy of a Riboflavin and Ultraviolet Light-Inactivated Whole-Virion SARS-CoV-2 Vaccine in a Hamster Infection Challenge Model. | <b>Background:</b> A novel platform to produce whole-virion vaccines using riboflavin and ultraviolet (UV) light for photochemical inactivation has been developed. We previously reported on the potential for this platform to produce a safe and effective inactivated whole-virion SARS-CoV-2 vaccine. Feasibility studies u... |
41744977 | Hydrogels as Promising Carriers for Ophthalmic Disease Treatment: A Comprehensive Review. | Ocular disorders such as keratitis, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and dry eye disease (DED) are highly prevalent worldwide and remain major causes of visual impairment and blindness. Conventional therapeutic approaches for ocular diseases, such as eye drops, surgery, and l... |
41744695 | Portable Point-of-Care Uric Acid Detection System with Cloud-Based Data Analysis and Patient Monitoring. | Uric acid is closely related to diseases such as gout, kidney failure, and metabolic disorders. A conventional method for measuring uric acid over 24 h is time intensive and cumbersome for patients who have to take samples to the hospital. At present, hospitals use only laboratory instruments to determine 24-h uric aci... |
41718399 | Antibody Screening and Binding Prediction Analysis Targeting Stx2. | <b>Background</b>: Shiga toxin (Stx), produced by enterohemorrhagic <i>Escherichia coli</i> (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytotoxicity and poses greater clinical risk, yet no effective therapy ... |
41716468 | Targeted biologics for TNBC: Advances in nanobodies, antibodies, peptides, and aptamers. | Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression. This molecular profile limits responsiveness to hormonal or targeted therapies, often with poor outcomes and high recurrence. TNBC's heterogeneit... |
41704871 | Influences of pH-regulated metal phenolic networks on soy protein hydrolysate nanofibril gels: Microstructure, rheological properties and thermal stability. | Metal-phenolic networks (MPNs) are widely used to improve the structure, mechanical properties and stability of gels. In this study, tannic acid (TA) was coordinated with metal ions (Mn<sup>2+</sup> and Zn<sup>2+</sup>) under pH conditions of 2.0, 5.5, and 8.0 to form MPNs, which subsequently induced soy protein hydrol... |
41704299 | Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy. | Chemotherapy-induced cell apoptosis results in nuclear damage and the subsequent release of double-stranded DNA (dsDNA) fragments, which can stimulate the cGAS-STING pathway to initiate antitumor immune responses. However, this pathway may be less effective due to nonspecific systemic toxicity caused by chemotherapeuti... |
41696325 | Computational Investigation of 4‑Nitrophenol Inclusion Complexes with α‑, β‑, and γ‑Cyclodextrins. | The increasing presence of emerging contaminants, such as 4-nitrophenol (4-NP), in aquatic environments poses environmental and public health risks, driving interest in innovative systems capable of selectively removing them. Despite the well-established potential of cyclodextrins (CDs) as molecular hosts for the remov... |
41696284 | Antibacterial and Osteoinductive Ti Implants Derived from MOF-Engineered Magnesium Oxide. | Ti-based implants are widely applied in orthopedic repair and reconstruction, but their intrinsic bioinertness and susceptibility to implant-associated infection (IAI) remain major clinical challenges. To simultaneously improve antibacterial activity and osteogenic performance, we developed a structurally uniform and m... |
41696216 | Recyclable Hydrotalcite-Supported Copper Catalysts for Green and Regioselective Click Synthesis of 1,2,3-Triazoles. | This work reports a sustainable and highly efficient catalytic system based on cuprous oxide nanoparticles supported on hydrotalcite (<b>Cu</b> <sub><b>2</b></sub> <b>O@LDH-01</b>) for the regioselective synthesis of 1,2,3-triazoles via copper-catalyzed azide-alkyne cycloaddition (CuAAC) in aqueous media. The catalyst ... |
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