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41696206 | Screening of Natural Inhibitors from <i>Pleurotus ostreatus</i> against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation. | The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens. Recent animal studies suggest that inhibition of serine biosynth... |
41696192 | Investigating Marine Natural Products as Potential Antivirals of Mpox Virus Replication by Targeting Thymidylate Kinase. | The human Mpox virus (hMPXV), an orthopoxvirus in the <i>Poxviridae</i> family, has emerged as a global health threat. Although smallpox therapeutics have been repurposed in the absence of hMPXV-specific drugs or vaccines, they suffer from efficacy limitations and lengthy development timelines. Modern computational app... |
41683709 | Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems. | Brimonidine, a highly selective α<sub>2</sub>-adrenergic receptor agonist originally developed for glaucoma treatment, has emerged as an important dermatological agent due to its potent vasoconstrictive and anti-inflammatory properties. This review summarizes its pharmacological characteristics, and clinical applicatio... |
41683691 | Hemocompatibility Evaluation of PEGylated Bovine Hemoglobin. | Hemocompatibility is critical for intravenous hemoglobin-based oxygen carriers (HBOCs). We evaluated the hemocompatibility of polyethylene glycol-conjugated bovine hemoglobin (PEG-bHb) to facilitate its optimization and clinical translation. PEG-bHb was synthesized and characterized. In vitro hemocompatibility was asse... |
41683679 | Recent Advances in Polyoxometalates Targeting Proteins Associated with Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Applications. | Polyoxometalates (POMs) exhibit significant potential for application in Alzheimer's disease (AD) therapeutics owing to their inherent chemical and physical properties and structural tunability. Through transition metal substitution, functional modification, and the construction of POMs-based nanocomposites, POMs can p... |
41683678 | New Insights into Neuromuscular Junction Biology: Evidence from Human and Animal Research. | Neuromuscular junctions (NMJs) are highly specialized synapses that enable efficient communication between motor neurons and skeletal muscle fibers. Impaired formation or maintenance of NMJs is implicated in the pathogenesis of multiple neuromuscular disorders and contributes to age-related declines in skeletal muscle ... |
41683419 | Impact of Thymidine Loop Modifications on Telomeric G-Quadruplex Catalytic Systems for Asymmetric Sulfoxidation. | G-quadruplex (G4) DNA structures have recently emerged as promising chiral scaffolds for enantioselective catalysis. This study investigates how thymidine loop modifications influence the catalytic performance of the telomeric G4 sequence HT21 in the asymmetric sulfoxidation of thioanisole. To this end, several singly ... |
41683417 | Artificial Intelligence for Perovskite Additive Engineering: From Molecular Screening to Autonomous Discovery. | Additive engineering plays a crucial role in enhancing the performance of perovskite solar cells (PSCs), yet identifying suitable additives within the vast chemical space remains a significant challenge. This paper describes a paradigm shift in additive discovery from trial-and-error methods to AI-driven approaches. We... |
41683410 | Biochar Innovations for Organic Pollutant Remediation in Contaminated Soils. | Soil contamination by organic pollutants such as polycyclic aromatic hydrocarbons (PAHs), pesticides, pharmaceuticals, and petroleum hydrocarbons has emerged as a global environmental concern due to their persistence, bioaccumulation, and potential health risks. Biochar, a carbon-rich material derived from the pyrolysi... |
41683042 | PLA/Starch Composites: New Applications as Control Release Materials. | Poly(lactic acid) (PLA)/starch composites have attracted considerable attention as promising eco-friendly materials due to their renewable origins and complementary properties. The system synergized benefits including cost reduction and enhancing biodegradation through filled with starch, and reducing moisture sensitiv... |
41682045 | Research Progress in Chitin/Chitosan-Based Biomass Adhesives: Extraction Processes, Composite and Chemical Modification. | Traditional fossil-based adhesives, hindered by issues such as formaldehyde emission, dependence on fossil resources, and poor biodegradability, struggle to meet the global demand for low-carbon green development. Biomass-based adhesives have thus emerged as a core alternative. Among them, chitin/chitosan derived from ... |
41682043 | Advances and Applications of Block Copolymers II. | Polymers are an essential class of materials; they are constantly evolving, and new monomers/polymers are being synthesized and/or produced every day [...]. |
41681200 | Hydrogel-Flexible Electronics Integrated Platforms for Diabetic Wound Management. | Diabetic wounds are a major clinical challenge, driven by hyperglycemia, oxidative stress, persistent inflammation, and bacterial infection. Conventional dressings offer limited benefit, creating demand for advanced therapeutic strategies. This review analyzes hydrogel-based wound dressings and flexible electronic devi... |
41677608 | Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies. | Tau proteins are microtubule-associated proteins that regulate axonal structure, dynamics, and transport, and their dysregulation underlies several neurodegenerative diseases. The <i>MAPT</i> gene produces multiple tau isoforms through alternative splicing, including the high-molecular-weight isoform known as Big tau, ... |
41677524 | Core-Shell Plasmonic Nanocomposites with Synergistic Photothermal and Photochemical Activity for Biomedical Applications. | Nanomedicine changes our lives by impacting diagnostics and therapeutics. In the biomedical domain, core-shell nanostructures have significant potential for photothermal therapy, diagnostics, sensing, drug delivery, and imaging. This work reviews the synergistic photothermal and photochemical effects of core-shell nano... |
41677522 | Nanomaterial-Enabled Modulation of Tumor-Associated Macrophages and Dendritic Cells to Enhance Cancer Immunotherapy. | Tumor-associated macrophages (TAMs) and dendritic cells (DCs) play pivotal roles in shaping the tumor immune microenvironment, often contributing to immunosuppression and therapy resistance. Recent advances in nanotechnology have enabled precise modulation of these immune populations, offering a promising avenue to enh... |
41676217 | Antimicrobial resistance and real-time PCR detection of <i>blaKPC</i> in <i>Klebsiella pneumoniae</i> isolated from wound infections in a tertiary care hospital. | <h4>Background</h4><i>Klebsiella pneumoniae</i> is a common Gram-negative bacterium frequently associated with wound infections. A major public health concern is the emergence of carbapenem-resistant strains, particularly those carrying the <i>blaKPC</i> gene. This study aimed to detect the <i>blaKPC</i> gene and to de... |
41676139 | Rewiring tumor-associated macrophages in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with limited responsiveness to immune checkpoint inhibitors (ICIs). Accumulating evidence indicates that tumor-associated macrophages (TAMs) are central regulators of the immunosuppressive tumor microenvironment (TME) and majo... |
41676136 | The gut-lung axis in COPD: immunomodulatory roles of gut microbiota and novel therapeutic strategies. | Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and systemic inflammation, with accumulating evidence implicating gut microbiota dysbiosis as a key modulator of disease pathogenesis via the gut-lung axis. This review synthesizes current k... |
41675681 | Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing. | The structural failure of rotator cuff repair is largely attributed to fibrovascular scar formation driven by a persistent inflammatory microenvironment and insufficient fibrocartilage regeneration at the tendon-to-bone interface. To address this, a microfluidic-generated GelMA microsphere system co-encapsulating Zeoli... |
41675455 | Isolation and evolutionary analysis of feline panleukopenia virus strains FPV-BJ-J2 and FPV-BJ-J3 (T440A, N564S, A568G) in Beijing, China. | Feline panleukopenia virus (FPV) is a single-stranded linear DNA virus with high lethality, whose VP2 protein determines viral host range and antigenicity. Substitutions at several key VP2 residues are closely associated with enhanced virulence and immune evasion. However, their patterns and temporal evolutionary dynam... |
41675422 | Reactive lithium fluoride revitalizes bulk-interface Na-ion transport in all-solid-state PEO-based sodium batteries. | Poly(ethylene oxide) (PEO)-based electrolytes suffer from low ionic conductivity and interfacial instability, which collectively impede their practical implementation in all-solid-state sodium metal batteries (ASSMBs). Conventional molecular-level strategies aim to enhance Na<sup>+</sup> conduction by regulating polyme... |
41675284 | Role of lactylation modification in regulating lytic cell death. | Historically, lactate has been regarded primarily as the terminal product of glycolysis. However, recent research has elucidated its critical function as an epigenetic regulator via lactylation modification. Lactylation represents a novel post-translational modification (PTM) characterized by the covalent attachment of... |
41675219 | Punicic acid ethyl ester, a superior absorption-enhancer over pomegranate seed oil, dramatically improves quercetin bioavailability <i>via</i> strong interaction and rapid lipolysis. | Low oral bioavailability remains a major challenge for drug delivery. Fatty acids (FAs) and vegetable oils have attracted great interest as absorption enhancers due to their excellent compatibility. However, the difference in absorption-enhancing efficiency of various FA chemical forms and the underlying mechanisms rem... |
41674973 | Therapeutic application of IL-12 for cancer therapy. | Interleukin-12 (IL-12) is a pleiotropic pro-inflammatory cytokine with potent antitumour activity and has been extensively explored as a candidate for cancer immunotherapy. However, its clinical development has been severely limited by the substantial systemic toxicities observed following systemic administration of re... |
41674936 | Role of TRAIL in mediating the effect of lipidome on breast cancer: a Mendelian randomization study. | <h4>Background</h4>Breast cancer (BC) is the most common malignancy in women and remains a major cause of cancer-related death. Growing observational and multi-omics evidence suggests that dysregulated lipid metabolism and alterations in circulating lipidomes are involved in BC development, yet their causal relationshi... |
41674904 | Broad-spectrum inhibition of SARS-CoV-2 variants by dibutyl phthalate through allosteric disruption of Spike-ACE2 interface. | <h4>Introduction</h4>The persistent evolution of SARS-CoV-2 has diminished the efficacy of existing vaccines and antibodies, increasing the risks of reinfection and Long COVID. There is a significant need for the development of convenient, broad-spectrum antiviral agents that target the early stage of viral infection. ... |
41660127 | NIR-II imaging-guided nanoplatform for synergistic mitochondria-targeted pyroptosis and macrophage reprogramming immunotherapy. | Cancer immunotherapy has revolutionized modern oncology by mobilizing the body's immune system, yet its efficacy remains severely limited in immunologically "cold" tumors, which are defined by poor immune infiltration and low tumor immunogenicity. Here, we report a multi-functional nanoplatform that integrates a new se... |
41647036 | Efficient pure-red multiple resonance emitter based on a donor planarization strategy. | Efficient pure-red multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters compatible with vacuum thermal evaporation remain scarce, which hampers the development of wide color gamuts for ultra-high-definition displays. The prevailing approach connecting one or more donors to the highest occupied... |
41643434 | Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens. | Excessive accumulation of abdominal fat (AF) reduces feed efficiency and carcass yield, posing a significant challenge to the poultry industry. However, the molecular network underlying age-dependent AF development remains unclear, despite some recent progress. In this study, we quantified the abdominal adipocyte area ... |
41605212 | Metabolically regulated proteasome supramolecular organization in situ. | Many proteins localize in membraneless organelles. However, understanding the steps along membraneless organelle formation-and the structural impact on granule constituents-has been hindered by limited resolution of intracellular data. We address these challenges through in situ cryo-electron tomography (cryo-ET) along... |
41621263 | Protein/virus-imprinted self-assembled monolayers for real-time selective detection. | The imprinting of proteins and viruses remains among the most formidable challenges. This article reviews protein/virus-imprinted self-assembled monolayers (SAMs) fabricated in aqueous media containing alkanethiols and protein/virus templates on smooth and rough gold surfaces by self-assembly of alkanethiols around pro... |
41621160 | Trace-level detection of free polycyclic aromatic hydrocarbons based on magnetic driving and deep learning-assisted recognition. | Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants with strong carcinogenicity and bioaccumulation, posing serious threats to aquatic ecosystems and human health. However, the sensitive and accurate detection of trace-level PAHs in water remains a significant challenge. In this study, a surface-e... |
41619626 | Macropore engineering of MOF-derived carbon for superior microwave absorption. | Regulating electromagnetic pollution has become significance as 5G communication and radar technologies rapidly progress. This study proposes a macroporous engineering method utilizing polystyrene microsphere templates to address the limitations of single pore size structure and the difficulties in achieving impedance ... |
41619326 | Stabilizing an scu-topology Zr-MOF via linker installation for enhanced gas chromatographic separation. | Flexible metal-organic frameworks (MOFs) with dynamic adaptability offered exciting opportunities for advanced separation, yet their tendency to undergo void collapse severely limited their application as gas chromatography (GC) stationary phases. Here, we overcame this challenge by stabilizing the scu-topology Zr-MOF ... |
41616448 | Antioxidant and antibacterial nanofiber films via electrospinning of ZIF-8-encapsulated nisin in PCL/chitosan matrices. | To enhance fruit preservation efficacy, nisin (NIS) was encapsulated within zeolitic imidazolate framework-8 (ZIF-8) to form a ZIF-8/NIS composite. This composite was integrated into polycaprolactone/chitosan (PCL/CS) nanofibers via electrospinning (ELS), fabricating active packaging membranes. Characterisation reveale... |
41616438 | Development of zein-soy protein isolate-rutin supramolecular nanoparticles via pH-ultrasound-shifting method: Structural characterization, stability, and gastrointestinal bioaccessibility. | Rutin, a natural flavonoid, has limited applications in functional foods due to its low aqueous solubility. To address this, this study fabricated zein-soy protein isolate-rutin supramolecular nanoparticles using the pH-ultrasound-shifting method (ZS-R-P-U), achieving a high encapsulation efficiency (89.06 ± 2.16%). Mu... |
41608525 | Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives. | Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by metabolic dysregulation, highlighting the need for therapeutic strategies that ena... |
41608478 | Eco-engineered bio-based palladium MOF-chitosan-carboxymethyl cellulose composite sponge: mechanistic insights, Box-Behnken optimization, and high-performance reusability for advanced ciprofloxacin removal from wastewater. | In this work,a new bio-based palladium metal-organic framework (Pd-MOF)/chitosan (CS)-carboxymethyl cellulose (CMC) composite (PMCC) sponge created by inserting a Pd-MOF into a medium comprising CS and CMC. The PMCC sponge was produced <i>via</i> a straightforward, environmentally friendly technique and was verified as... |
41607480 | Biochar for pollution mitigation and renewable energy applications toward sustainability development. | In the context of fossil fuels polluting the environment and depleting energy resources, the need to find sustainable solutions becomes urgent; in which, biochar stands out thanks to its potential applications in the fields of energy and environment. Biochar is produced from biomass and possesses advantageous structura... |
41613642 | In silico prediction, molecular docking and simulation of natural flavonoid apigenin and xanthoangelol E against human metapneumovirus. | Human metapneumovirus (hMPV) is one of the potential pandemic pathogens, and it is a concern for elderly subjects and immunocompromised patients. There is no vaccine or specific antiviral available for hMPV. We conducted an in-silico study to predict initial antiviral candidates against human metapneumovirus. Our metho... |
41605400 | A colorimetric DNA chimera biosensor based on bivalent split aptamers and G-quadruplex DNAzyme to detect norfloxacin in seafood. | Norfloxacin (NOR) residue in animal-derived food poses a significant concern due to its role in fostering bacterial resistance and potential human health risks, necessitating rapid and sensitive detection methods. In this study, a colorimetric DNA chimera biosensor was developed by integrating a bivalent split aptamer ... |
41601154 | Tailor-Made Tetradentate Bis(Pyridyl Triazole) Pincer Ligands toward Selective Complexation and Extraction of Palladium. | Efficient separation of palladium (Pd) from high-level liquid waste (HLLW) is critically important, considering its scarcity in natural resources and associated issues regarding nuclear waste disposal. However, this remains challenging due to the extreme compositional complexity and high acidity of HLLW. Inspired by th... |
41593640 | Deciphering the intratumor microbiota in malignant gastrointestinal tumors: multifaceted interplay and clinical implications. | With the development of next-generation sequencing methods, the presence of flora has been detected in otherwise sterile tumour tissues, and intratumoural flora has a role in tumour diagnosis suggesting prognosis due to its heterogeneous nature. Studies have shown that intratumoural flora may contribute to cancer devel... |
41593489 | Microalgae as novel drug-delivery system for biomedical field. | Currently, increasing attention is being paid to the extraction and utilization of materials with special biological activities in nature or for medical applications. Owing to their unique biological characteristics and diverse application potential, microalgae are among the most promising materials in the field of bio... |
41593460 | Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects. | Mitochondria are central to health and disease by precisely regulating metabolism and interacting closely with other organelles. Mitochondrial dysfunction contributes to the initiation and development of numerous diseases, including cancer. In cancer cells, metabolic reprogramming, impaired mitochondrial quality contro... |
41593466 | Design and computational evaluation of a prophylactic and therapeutic multi-epitope vaccine candidate against cervical cancer. | Cervical cancer is the fourth most common cancer among women worldwide, caused by the human papillomavirus (HPV). HPV16 /18 are strongly associated with the development of cervical cancer. HPV vaccines are not widely available in economically underdeveloped areas. They also have limited efficacy against pre-existing HP... |
41593180 | Green synthesis of activated carbon-ZIF-8 nanocomposites from pistachio hulls for efficient antibiotic adsorption in water remediation. | Water contamination by antibiotics like tetracycline (TC) and amoxicillin (AMX) poses serious environmental and health risks, necessitating effective removal techniques. This study synthesized activated carbon (AC) from pistachio hull powder (P) and used it as a support for Zeolitic Imidazolate Framework-8 (ZIF-8) to c... |
41593083 | Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation. | Cell-autonomous immunity represents evolutionarily conserved defense mechanisms present in both immune and non-immune cells. One of such mechanisms is mediated by cytoskeletal septins that entrap cytosolic bacterial pathogens within cage-like structures. To promote infection, Shigella flexneri delivers effector protein... |
41593087 | Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo. | Self-amplifying mRNA (saRNA) vectors hold promise for the sustained expression of mRNA vaccines in vivo. However, their inherently high immunogenicity and low-fidelity replication-stemming from the RNA viral genome's replication mechanisms-limit their efficacy as replacements or adjuncts to protein therapies. Here we r... |
41593077 | Unlocking enzymatic deracemization of structurally diverse allenes by designed photoenzymes. | Precise three-dimensional arrangements of atoms and functional groups govern molecular reactivity and biological function, making stereocontrol a central goal in modern organic and medicinal chemistry. Yet reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective ... |
41593065 | Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex. | The SEL1L-HRD1 complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD), a critical quality-control pathway that clears misfolded ER proteins. However, the molecular organization and pathogenic mechanisms of mammalian ERAD have remained elusive. Here, we report the cryo-E... |
41593052 | Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation. | The human ClpXP complex (hClpXP) orchestrates mitochondrial protein quality control through targeted degradation of misfolded and unnecessary proteins. While bacterial ClpXP systems are well characterized, the assembly and regulation of human ClpXP remain poorly understood. In this study, we elucidate the complete asse... |
41593019 | Confining Amphiprotic Proton Source in Polyoxometalate-Based Metal-Organic Frameworks for Enhancing Proton Conduction. | Confining amphiprotic proton sources within the framework of crystalline materials is recognized as an effective strategy for improving their proton conductivities. Two new compounds ([(TPA)(AlMo<sub>6</sub>O<sub>24</sub>)]·3H<sub>2</sub>O, named as CUST-841 and [Zn<sub>2</sub>(HSO<sub>4</sub>)<sub>2</sub>(TPA)<sub>2</... |
41593011 | Precise Pore Engineering of a Pillar-Layered MOF via the Dual-Ligand Strategy for C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> Separation. | The efficient separation of acetylene (C<sub>2</sub>H<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) is of major practical importance but remains difficult because of their analogous physical properties. The dual-ligand strategy provides an effective approach to tailor pore structure and chemical microenvironments fo... |
41592917 | Optimization of Cu-Doped ZnO Nanomaterials for Ultrasensitive Detection of Trace Formaldehyde under Room Temperature and UV Light Activation. | Formaldehyde (HCHO) is a common indoor volatile organic compound (VOC) gas, which seriously endangers human health. How to accurately and rapidly detect HCHO concentration has become an important and urgent issue. Among various detection technologies, semiconductor photoelectric gas sensors with metal oxide materials a... |
41592915 | Near-Infrared Photonic Metal-Organic Frameworks. | ConspectusNear-infrared (NIR) light, especially NIR-II light (1000-2000 nm), has shown extensive applications in military and civilian fields such as night vision, biomedicine, optical communication, and noninvasive detection due to its superior penetration capabilities, invisibility to human eyes, less background inte... |
41592796 | Adsorption Mechanism in Crystalline Micropores: Multimodal Fluctuations, Metastability and Phase Transformations in Nanoconfinement. | Understanding molecular adsorption in microporous materials is key to advancing gas separation, storage, and catalysis. Here, we study CO<sub>2</sub> and CH<sub>4</sub> adsorption in crystalline metal-organic frameworks (IRMOF-1, 8, 10, and 14), emphasizing the emergence of metastable states. Molecular simulations reve... |
41592591 | Spin-Polarized Electron Transport and Catalytic Enhancement in Chiral Supramolecular Polymer Assemblies. | Chirality is recognized as a vital factor in generating strong spin selectivity in organic π-conjugated systems. In recent years, chiral polymers and supramolecular assemblies have attracted interest as potential spin-filtering materials because of the chirality-induced spin-selectivity (CISS) effect. However, despite ... |
41592440 | Kinetic Profiling in One-Step Digital Immunoassays Enables Multiplex Quantification across an Ultrabroad Dynamic Range. | In one-step sandwich immunoassays, where all binding components coexist in solution, excessive analyte levels can inhibit sandwich complex formation by competing with labeled detection antibodies, producing the well-known "hook effect." Here we establish a kinetic framework that resolves this ambiguity by analyzing tim... |
41592293 | Conformational Landscape of 1,3-Bis[oxo/thioxo-thiazolinyl] Aromatic Compounds with Two C-N Chiral Axes: A <b><sup>15</sup></b>N NMR and DFT Study. | DFT calculations have been used to investigate the conformational landscape of a library of 1,3-bis[oxo/thioxo-thiazolinyl] aromatic compounds with two stereogenic C<sub>sp2</sub>-N<sub>sp2</sub> axes (63 compounds). The good correlation between the experimental and DFT-calculated rotational barriers for five of these ... |
41592254 | Metal-Organic Framework-Based Supercapacitors: A Comprehensive Review. | Metal-organic frameworks (MOFs) are considered to be one of the important class of materials for energy storage devices, particularly for supercapacitors (SCs), having tunable pore sizes, large surface area, and the possibility of numerous organic-inorganic compositions. This review covers various synthesis strategies ... |
41592231 | Wearable In Situ SERS Sensors Based on the Metal@MOF Particle-in-Cavity Model: Suitable for Detection of Multifarious Biomarkers in Different Biofluids of Humans. | Biofluids are ideal sample sources for wearable in situ surface-enhanced Raman scattering (IS-SERS) sensors due to their noninvasive collection. However, the limited spatial reach of conventional hot spots (HSs), coupled with the fluidic and biocomplex nature of biofluids, means that only a small portion of target anal... |
41592217 | Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out. | Formulating cationic polyplexes (PP) with polyanions as ternary polyelectrolyte nanoparticles (TNP) offers a polymeric alternative to lipid nanoparticles (LNP) for targetable nucleic acid delivery. Although TNP <i>in vivo</i> transport is credited to their anionic surface charge, the relationships between polyanion che... |
41592176 | Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry. | We describe a semisynthetic strategy that unites the versatility of chemical peptide synthesis with the high affinity and specificity of antibody fragments to create conjugates with remarkably potent anti-HIV activity. Using site-selective enzymatic ligation and click chemistry, we assembled nanobody-fusion inhibitor p... |
41592114 | A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections. | Ebola virus (EBOV) causes recurring outbreaks, with a case fatality rate of about 40%. Currently approved vaccine and antibody therapies face major limitations, including only modest reductions in mortality and restricted accessibility due to their reliance on injection-based delivery and cold-chain transport and stora... |
41592003 | Chemodivergent Synthesis of 1,4-Benzo[<i>b</i>]dithiins and 1,4-Benzodithiafulvenes. | We report a chemodivergent synthesis of 1,4-benzo[<i>b</i>]dithiins and 1,4-benzodithiafulvenes from 2-iodoaryl alkynyl sulfides using a NaSH·<i>x</i>H<sub>2</sub>O/KOH system. In DMF, the reaction affords six-membered 1,4-dithiins, whereas in DMSO, these intermediates undergo a base-promoted ring contraction to the co... |
41591808 | Quasi-3D Plasmonic Metamaterials with Highly Stretch-Tunable Optical Responses. | Three-dimensional (3D) assemblies of metal nanoparticles (NPs) exhibiting strong plasmonic responses have garnered significant interest owing to their potential in optoelectronic and sensing applications. However, the realization of active plasmonic metamaterials based on such architectures remains nontrivial, particul... |
41591594 | Molecular gatekeepers: eukaryotic translation factors decoding plant-virus dynamics for resistance engineering. | Plant viruses are among the most significant biotic stressors, posing a severe threat to crop productivity and global food security. Their success largely depends on the exploitation of host eukaryotic translation factors (eTFs), including initiation factors (eIFs) and elongation factors (eEFs), which act as molecular ... |
41591459 | Synthesis of biocompatible novel multi-tailed indole-based resorcinarene for effective delivery of quercetin against multidrug-resistant S. aureus. | Resorcine-based macrocycles have received significant attention in drug delivery applications owing to their tunable functional groups, well-defined cavities, and inherent self-assembly behavior, considering essential for encapsulation and controlled release of loaded drug candidates. However, existing resorcinarene de... |
41591406 | Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. | Pyridomycin is a natural product with potent activity against <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), acting through direct inhibition of the fatty acid synthesis enzyme InhA. As a direct inhibitor, pyridomycin maintains activity on <i>Mtb</i> strains resistant to the InhA targeting prodrugs isoniazid and ethio... |
41591303 | Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1. | Viral infection is one of the conditions that induce stress granule (SG) formation, a cellular defense mechanism that exerts antiviral effects. To counteract this host response, viruses have evolved a broad spectrum of strategies to inhibit SG formation. However, the molecular mechanisms underlying SG inhibition remain... |
41591288 | Comprehensive structural analysis of bromine-substituted ferrocenyl chalcones. | A structural analysis is developed for five bromine-substituted ferrocenyl chalcones; the crystal structures of three of these compounds are reported for the first time. 3-(4-Bromophenyl)-1-ferrocenylprop-2-en-1-one (1), 3-(3-bromophenyl)-1-ferrocenylprop-2-en-1-one (2), 3-(2-bromophenyl)-1-ferrocenylprop-2-en-1-one (3... |
41591272 | When Reality Defies Prediction: Polymorphism, Twinning, and Accordion Crystals. | The ability to understand crystallization and predict the resulting solid form of a system is not always easily achieved, but it is critical, particularly in the field of materials science. Intriguing (and previously unreported) crystallization behavior is observed with terephthalic dihydrazide (TeDi) as it rapidly for... |
41591256 | Universal Antibody-Engineered Lipid Nanoparticles Potentiate Chemo-Immunotherapy Against Triple-Negative Breast Cancer by Reprogramming Tumor Cell Metabolism. | Despite the promise of combining chemotherapy and immunotherapy for triple-negative breast cancer (TNBC), challenges remain due to targeting deficiencies and accelerated T cell exhaustion within the immunosuppressive tumor microenvironment (TME). To address these limitations, we developed a drug-encapsulated lipid nano... |
41591209 | Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis. | Cocrystals are solid crystals formed by the combination of multiple components through non-covalent interactions (NCIs). Despite their diverse structures and tunable optoelectronic properties, they cannot meet the demand for multi-functionalization of optoelectronic devices. Therefore, a series of strategies is summari... |
41591073 | Cooperative Rotation and Spin State Switching of Molecules in Artificial Arrays. | Artificial arrays of tin phthalocyanine molecules have been studied on Pb(100) using scanning tunneling microscopy (STM). The molecules adopt two azimuthal orientations with distinct spin states, which results in a checkerboard pattern in STM images. Upon converting the central molecule by current injection from its pr... |
41590997 | Thermodynamic Approach for Synthesizing [2]Catenanes from Borate Ion-Containing Crown Ethers and a Macrocyclic Ammonium Ion. | In this study, we synthesized [2]catenanes from bis-catechol spiroborate ion-containing crown ethers and a macrocyclic ammonium ion through hydrogen bonding and ion pairing. The borate-forming reaction of bis-catechol and trimethyl borate in the presence of an amino-ether-based macrocycle (amino macrocycle) initially f... |
41589846 | Microbial-Responsive Wound Dressings Based on Biopolymer Degradation Strategy for Detecting Bacterial Infections. | Chronic wounds remain a major clinical challenge due to their strong association with antibiotic-resistant microbial biofilms. These nonhealing wounds demand advanced therapeutic strategies that go beyond passive protection to actively monitor and respond to changes in the wound environment. To address this, we propose... |
41589834 | Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output. | Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca<sup>2+</sup> imaging has demonstrated that spatially overlapping ensembles of direct and indirect pathway SPNs (dSPNs, iSPNs) are co-active during ... |
41589832 | Electrostatically Tuned Graphene Oxide-Covalent Organic Framework Membranes for High-Flux Rejection of Low Molecular Weight Organic Compounds. | Achieving high water flux without compromising the rejection of low-molecular-weight organic compounds (LMWOCs) remains a key challenge in two-dimensional laminar membrane design. Here, we report a structurally tunable graphene oxide (GO)-covalent organic framework (COF) hybrid membrane assembled from sulfonated COF na... |
41589817 | Sulfone-Isoquinoline Dopants Activated Phosphorescence Beyond Room Temperature. | Purely organic room-temperature phosphorescence (RTP) materials are of growing interest for bioimaging, anti-counterfeiting, and optoelectronic applications. However, impurity-induced RTP has challenged the reliability of many reported single-component systems. Herein, we systematically investigated a series of sulfone... |
41589799 | Near-Infrared-Activated Multiphoton Photocatalytic System for Synergistic Therapy via CO Generation and •OH Production. | Light-triggered controllable carbon monoxide (CO) release represents a promising approach for cancer therapy but is limited by the poor tissue penetration of light and insufficient CO release rates within deep tumor microenvironments. Herein, inspired by near-infrared (NIR)-activated multiphoton photocatalysis, a novel... |
41589794 | Multiphysics-Driven Assembly of Biomimetic Vesicles. | Artificial extracellular vesicles (AEVs) are programmable, biomimetic materials that combine the structural and biological complexity of naturally secreted extracellular vesicles (NEVs) with the design flexibility of synthetic nanomaterials. A multiphysics-driven microfluidics is developed to efficiently integrate the ... |
41589763 | Engineered ETS1-Nanoconjugate Restores Immune Homeostasis through Dual Immune-Vascular Modulation in Relapsing and Progressive Multiple Sclerosis. | While current treatments for multiple sclerosis (MS) targeting T or B cells have shown clinical benefit, they remain insufficient due to the multifactorial and dynamic nature of MS pathogenesis. A key obstacle to restoring immune homeostasis lies in the reciprocal reinforcement between endothelial-to-mesenchymal transi... |
41589760 | Electron Transfer Mediator-Enabled Modular Control of <sup>1</sup>O<sub>2</sub> and O<sub>2</sub> <sup>•-</sup> Generation in Porphyrin Supramolecular Frameworks for Selective Photosynthesis. | The inherent preference of classical type II photosensitizers for generating singlet oxygen (<sup>1</sup>O<sub>2</sub>) via energy transfer presents a key challenge in developing type I systems capable of producing superoxide radicals (O<sub>2</sub> <sup>•-</sup>) through electron transfer. Herein, we report a porphyri... |
41589727 | Engineering the Solid-Electrolyte Interphase via NO<sub>3</sub> <sup>-</sup> Coordination at Open Metal Sites in HKUST-1 for Stable Lithium Metal Anodes. | Metal-organic frameworks (MOFs) are promising hosts for quasi-solid electrolytes (QSEs) by integrating liquid electrolytes (MOF@LE QSEs), yet stabilizing lithium metal anodes (LMAs) to enhance electrochemical performance remains a challenge. Here, we introduce a strategy leveraging open metal sites (OMSs) in HKUST-1 (C... |
41589708 | The Cotton Bollworm Larvae Use a Highly Expressed Odorant Receptor to Detect a Potent Insect Repellent, (-)-Bornyl Acetate. | <i>Helicoverpa armigera</i> is a typical polyphagous species whose larvae primarily bore in flower buds and fruits of host plants, causing serious damage to many crops. Olfaction plays a key role in host selection, but the molecular basis of olfactory perception in larvae is poorly understood. Herein, we identified a h... |
41589720 | A Polymer-Intercalated Modulation Assembly Strategy Towards Mesoporous Single-Crystalline BiVO<sub>4</sub> Materials for Enhanced Photocatalytic Performance. | The rapid recombination of photogenerated electron-hole pairs is a bottleneck constraining the improvement of photocatalytic efficiency. The construction of porous single-crystalline BiVO<sub>4</sub> is expected to resolve this issue and provide plenty of active sites for charge carriers to promote the catalytic reacti... |
41589687 | Population Pharmacokinetics of Clesrovimab in Preterm and Full-Term Infants. | Clesrovimab is a half-life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK-1654-002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants. The objectives... |
41589680 | FOCUS: A Four-In-One Consolidated Unison Strain Sensor with Enhanced Sensitivity. | Liquid metal strain sensors possess outstanding stretchability, low modulus, and excellent repeatability, making them ideal for large-deformation measurements. However, traditional liquid metal sensors inherently suffer from low sensitivity, which severely limits their capability in detecting subtle deformations. To ac... |
41589684 | Dichlorine-Containing Chlorothallate(III) (Me<sub>4</sub>N)<sub>3</sub>{[Tl<sub>2</sub>Cl<sub>9</sub>](Cl<sub>2</sub>)}: Crystal Structure and Thermal Stability. | The first example of a supramolecular complex of high-valent thallium(III)-containing "trapped" dichlorine, (Me<sub>4</sub>N)<sub>3</sub>{[Tl<sub>2</sub>Cl<sub>9</sub>](Cl<sub>2</sub>)} (<b>1</b>), has been prepared. <b>1</b> was characterized by X-ray single-crystal diffractometry, indicating the presence of the "trap... |
41589663 | Cascade-Responsive MXene@Cu-MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair. | Extensive tracheal repair is limited by oxidative injury, infection, and insufficient vascularization with delayed cartilage maturation. We developed cascade-responsive MXene@Cu-MOF heterostructures within gelatin methacryloyl (GelMA) hydrogels to enable staged tracheal repair. Copper-based metal-organic framework (Cu-... |
41589648 | Enhancing Chemical Stability and Molecular Selectivity of Porous Organic Cages via Core-Shell Polymer Coating. | Porous organic cages (POCs) have emerged as promising molecular materials for gas separation and storage due to their discrete, shape-persistent structures and accessible cavities. However, their practical application remains limited by intrinsic instability under harsh chemical environments and difficulties in process... |
41589632 | Mechanoresponsive Biomaterials: Principles, Mechanisms, and Applications. | Mechanoresponsive biomaterials are a revolutionary class of materials designed to respond dynamically to mechanical stimuli, providing tissue engineering and regenerative medicine with precise control over biological processes. Through processes including supramolecular interactions, strain stiffening, and force-induce... |
41589616 | Label-Free and Immobilization-Free Protein-Binding Assays by Ultraviolet Transient Absorption Microscopy. | Protein-ligand interactions are central to understanding biological mechanisms and drug discovery, yet conventional assays often rely on labeling or immobilization that can alter natural binding. Here, we introduce ultraviolet transient absorption microscopy (UV-TAM), which directly detects binding through ligand-induc... |
41589619 | Directional Regulation of Zinc Deposition Through Constructing Hierarchical Janus Carbon Matrix with Organic-Decorated Multi-Channels. | The development of rechargeable aqueous zinc-ion battery (AZIB) has been hampered by parasitic reactions, despite the low cost, high safety, and environmental friendliness. Here, we design an artificial interfacial layer using a hierarchical Janus carbon matrix on Zn anodes to direct Zn deposition behavior. By covalent... |
41589569 | Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System. | Surgical removal of bacterial plaque and antibiotic therapy have been widely used for the clinical treatment of periodontitis, which is driven by microbial dysbiosis and usually causes the loss of alveolar bone. However, key restrictions including drug resistance, poor anti-inflammatory effects, and limited bone repair... |
41589567 | In Situ Lipoprotein-seeking Dye for in Vivo Real-Time Imaging of Lipid Dysregulation Diseases. | Lipoproteins, critical transporters of cholesterol and triglycerides, are essential to cardiovascular health and pathology. However, imaging probes that can specifically target endogenous lipoproteins in situ are lacking. This study introduces an innovative lipoprotein-seeking near-infrared-II (NIR-II) dye for in vivo ... |
41589449 | Electrolyte-Gated Organic Electrochemical Transistor for Dynamic HMGB1 Detection in Acute Kidney Injury. | Early detection and continuous monitoring of acute kidney injury (AKI) are essential for preventing progression to chronic kidney disease (CKD). However, conventional renal biomarkers such as serum creatinine lack sensitivity for deterioration warnings. High mobility group box 1 (HMGB1), a pivotal damage-associated mol... |
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