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41589416 | Enantiospecific Optical Sensing of Terpenes by an Aggregated Atropisomeric Platinum(II) Complex. | Terpenes are unfunctionalized small volatile organic compounds (VOCs) that are naturally abundant, relevant to climate change, and impose potential health risks. Herein, we report a conceptually novel approach for the enantiospecific recognition of terpenes and other VOCs based on a square planar platinum(II) complex w... |
41589389 | Dual-Cross-Linked Self-Healing Hydrogels for 3D Cell Applications. | host-guest (βCD/adamantane) cross-linked hydrogels have received increasing attention in recent years for cell culture applications. A major challenge of these systems remains the lack of stability and mechanical integrity, which has led to the development of dual cross-linked gels mainly by combining the host-guest (β... |
41589345 | Highly Sensitive Zr-MOF-Amplified Electrochemical Immunosensor of Prostate-Specific Antigen with MWCNTs/AuNPs/MnO<sub>2</sub> Nanocomposites. | Prostate cancer remains one of the most prevalent malignancies affecting men worldwide. Early diagnosis plays a critical role in improving patient outcomes, with the measurement of prostate-specific antigen (PSA) levels in human serum analysis serving as a key strategy for early detection. In this study, we report the ... |
41588522 | Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation. | Antibiotics remain the recommended first-line therapy for eradicating Helicobacter pylori infection. However, the harsh gastric physicochemical environment severely limits drug bioavailability, contributing to treatment failure (~10%), gut dysbiosis, and the emergence of antimicrobial resistance. Inspired by H. pylori ... |
41588261 | Green bioconversion of insoluble chitin: chitinase development pathways via multi-strategy synergy. | As one of the most abundant natural polysaccharides on Earth, chitin is limited in its high-value utilization by its natural insolubility and high crystalline structure. Enzymatic degradation-especially via chitinases-serves as a highly promising approach for the green bioconversion of insoluble chitin. This review sys... |
41588247 | Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer. | Cuproptosis, a recently identified copper-dependent form of regulated cell death, is driven by mitochondrial dysfunction caused by copper overload. Cuproptosis results from proteotoxic stress, which is triggered by copper-induced aggregation of lipoylated tricarboxylic acid (TCA) cycle enzymes and destabilization of ir... |
41588187 | Synthetic biology for heparin biomanufacturing. | Heparin, mainly used as an anticoagulant, has also shown potential in the treatment of diseases such as inflammation and cancer. Currently, heparin is mainly extracted from the intestinal mucosa of pigs. However, due to concerns about disease transmission and contamination associated with animal-derived products, bioma... |
41588140 | Phytochemical, in silico, and in vitro studies of wheatgrass (Triticum aestivum L.) juice powder. | Wheatgrass (Triticum aestivum L.) is a functional food rich in phenolic compounds with demonstrated antioxidant and potential anticancer properties. Its phenolic compounds, vitamins, minerals, and enzymes are the main contributors to its positive health effects. In this study, the phenolic profile of wheatgrass juice p... |
41587998 | Ultrahigh-radiance TTA-based OLED with 13 kA cm<sup>-</sup><sup>2</sup> current injection. | Organic semiconductors have been widely utilized in displays, solar cells, detectors, and other fields due to their tunable optoelectronic properties and simple fabrication processes. However, fabricating organic electrically pumped lasers remains an unresolved challenge. The low mobility of organic molecules struggles... |
41574551 | Redox responsive cyclodextrin-based drug delivery systems: a special insight to glutathione responsive CD-nanosponges. | <h4>Introduction</h4>Advances in nanotechnology and nanomedicine increasingly focus on the rational design of smart nanocarriers capable of site-specific and stimulus-triggered drug release to improve therapeutic efficacy and reduce systemic toxicity. Among them, cyclodextrins (CDs), particularly cyclodextrin nanospong... |
41521900 | Cooperation of the stereo effect and host-guest interactions towards the electrochemical detection of dopamine. | Dopamine (DA) is an important neurotransmitter for the central nervous system related to Parkinson's disease, schizophrenia and so on, whose facile detection is in high demand. Combining both stereo and host-guest interactions according to the size and substituents of DA, a Cu-based metal-organic framework (MOF) with a... |
41511792 | From polyamines to nanogels: a supramolecular approach for boosting relaxivity of [Gd(DOTP)]<sup>5</sup>. | Supramolecular chemistry has played a central role in advancing the development of more effective contrast agents (CAs) for magnetic resonance imaging (MRI). By incorporating Gd(III) complexes into larger supramolecular architectures, host-guest interactions can be exploited to enhance both performance and targeting. O... |
41510825 | Cobalt MOF-derived Co/CoO/C composites for efficient peroxymonosulfate activation and oxytetracycline degradation. | A new cobalt MOF (JLNU-15, JLNU = Jilin Normal University) was synthesized and used as a precursor to produce carbon material Co/CoO/C-800 by pyrolysis at 800 °C. The Co/CoO/C-800 was characterized by SEM, TEM and XPS. This study employed a Co/CoO/C-800 composite material as a catalytic agent to initiate PMS for OTC re... |
41510626 | A green bismuth metal-organic framework catalyzing RDX combustion and thermal decomposition. | To improve the combustion performance of a solid propellant and study a new environmentally friendly combustion catalyst simultaneously, we synthesized a novel green combustion catalyst, [Bi<sub>2</sub>(pzdc)<sub>4</sub>]·2DMF, based on 2,3-pyrazinedicarboxylic acid with multiple coordination sites and green metallic b... |
41493212 | Self-assembled nanocomposite of HKUST-1 and LAPONITE®: towards a hydrogel with high mechanical strength for selective dye adsorption and column chromatographic separation. | Herein, we report the synthesis of a novel hydrogel nanocomposite, HKUST-1@LP, through the self-assembly of a prototype metal-organic framework (MOF), HKUST-1 and the nanoclay, LAPONITE® (LP). The nanocomposite was characterized by using different techniques including PXRD, FESEM, EDX, FTIR, TGA, rheology, zeta potenti... |
41492931 | Highly selective separation of toluene/methylcyclohexane using clamparene-based 3D porous crystals. | We demonstrate the application of clamparene-based 3D porous crystals as a purifying agent to effectively remove toluene from a mixture of methylcyclohexane and toluene. We found that clamparene can selectively adsorb toluene in a mixture of toluene and methylcyclohexane <i>via</i> host-guest interactions, achieving up... |
41492928 | Novel neodymium-based porphyrin metal-organic frameworks for dual-mode detection of iron ions. | Effective identification of iron (Fe<sup>3+</sup>) ions in the environment and food supplements is essential but challenging. Though traditional single-mode fluorescent sensing methods are user-friendly and sensitive, their accuracy is prone to being affected by external factors. Therefore, it is necessary to propose m... |
41489626 | β-barrels from short macrocyclic peptides. | β-Barrels are ubiquitous motifs in protein structures, but the fundamental rules underlying their formation are unclear, and their <i>de novo</i> design remains highly challenging. Small peptides that form barrels are especially scarce. Here, we report barrels with the shortest staves (6 residues, ∼60% of previous reco... |
41439334 | Emergent properties of supramolecular peptide assemblies. | The self-assembly of supramolecular monomers can change their chemical properties and produce emergent functions that are absent in their dispersed state. In this review article, we describe structural and functional material properties emerging from the self-assembly of peptides, which are based on interactions betwee... |
41408847 | Tracking <i>in situ</i> transformation of metal-organic frameworks into layered double hydroxides during synthesis and alkaline water oxidation through <i>operando</i> mechanistic studies. | Metal-organic frameworks (MOFs) have become powerful precursors for generating layered double hydroxides (LDHs) with excellent oxygen evolution reaction (OER) activity, yet the mechanistic pathways guiding their transformation remain unclear. Existing reviews largely emphasize synthetic routes and performance metrics, ... |
41358925 | Accelerating Discovery of Leukemia Inhibitors Using AI-Driven Quantitative Structure-Activity Relationship: Algorithm Development and Validation. | <h4>Background</h4>Leukemia treatment remains a major challenge in oncology. While thiadiazolidinone analogs show potential to inhibit leukemia cell proliferation, they often lack sufficient potency and selectivity. Traditional drug discovery struggles to efficiently explore the vast chemical landscape, highlighting th... |
41347491 | A comprehensive review of the spodium bond as a new crystal engineering motif in Zn/Cd complexes: challenges and future perspectives. | Currently, noncovalent interactions (NCIs), σ/π holes, and spodium bonds (SpBs) are intriguing areas of research in coordination chemistry. Thus, this branch of chemistry offers valuable opportunities for exploration. Still, challenges remain in recognizing the functions of metal complexes in NCI and SpBs. Over the las... |
41307361 | CO<sub>2</sub> photoreduction with heterogeneous organic photocatalysts based on π-conjugated monomers: structure-property insights and regulation strategies. | The visible-light-driven photoreduction of CO<sub>2</sub> into value-added chemicals is regarded as a promising approach to alleviating the energy crisis and addressing climate change. Heterogeneous organic photocatalysts based on π-conjugated monomers, including organic polymers/organic supramolecules composed of π-co... |
42006042 | Structurally Engineered Ferrous Metal-Organic Framework as a Chemodynamic Therapy Nanoagent for Concurrent Hydroxyl Radical and Singlet Oxygen Generation. | Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal-based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that g... |
41768463 | Highly Thermally Stable and Miscible CO<sub>2</sub>‑Based Block Copolymers by the Combination of Ring-Opening and RAFT Copolymerizations through Mediated Hydrogen Bonding Interactions. | In this study, the chain end of a reversible addition-fragmentation chain transfer (RAFT) polymerization agent of poly-(cyclohexene carbonate) (PCHC) was synthesized via the ring-opening copolymerization of CO<sub>2</sub> and cyclohexene oxide (CHO) by using s-dodecyl-s'-(α,α'-dimethyl-α″-acetic acid) trithiocarbonate ... |
41755928 | Intraoperative Severe Anaphylactic Shock to Sugammadex in an Anesthesia-Naïve Patient. | Sugammadex is a revolutionary drug for the reversal of neuromuscular blocking agents (NMBAs). It is a modified gamma cyclodextrin that directly binds and inactivates steroidal nondepolarizing neuromuscular blockers to facilitate reversal with fewer adverse effects than previously used reversal agents. In general, liter... |
41755830 | Illuminating Synergistic Catalysis: SET-HAT Unlocks Proximal C-H Arylation of Aromatic Amines. | The regioselective arylation of a free aromatic amine moiety is a challenging synthetic process, yet it is an essential one in the development of many value-added compounds. Here, we present an alternate strategy for the photoinduced <i>ortho</i> C-H arylation of anilines and alpha-arylation of pyrrole with aryl halide... |
41754905 | Nanotechnology-Enabled Precision Therapy for Lung Cancer in Never-Smokers. | Lung cancer in never-smokers (LCINS) represents a distinct clinical entity driven by dominant oncogenic alterations and characterized by a low tumor mutational burden. Although tyrosine kinase inhibitors (TKIs) achieve high initial response rates, their long-term efficacy is limited by suboptimal pharmacokinetics, rest... |
41754755 | Chitosan-Based Thermosensitive Hydrogel Loaded with Quercetin Inclusion Compound for Accelerating Infectious Wound Healing. | <b>Background</b>: Chitosan-based hydrogels exhibit excellent temperature-sensitive properties and are widely used as skin dressings. However, several challenges remain, such as long gelation times and difficulties releasing insoluble drugs, which limit their application in skin wound healing. In this study, we develop... |
41746038 | Using Machine Learning to Identify Factors Affecting Antibody Production and Adverse Reactions After COVID-19 Vaccination. | <b>Background:</b> Coronavirus disease 2019 (COVID-19) vaccines deliver mRNA packaged in lipid nanoparticles via intramuscular injection. This study investigated several factors influencing antibody production patterns and adverse reactions after vaccination with COVID-19 vaccines. <b>Methods:</b> Among the participant... |
41745492 | Quantitative Characterization of Microfiltration Membrane Fouling Using Optical Coherence Tomography with Optimized Image Analysis. | Membrane fouling reduces permeate flux and treatment efficiency, yet most diagnostic methods are destructive and require offline analysis. Optical coherence tomography (OCT) enables in situ, real-time visualization; however, quantitative image extraction of thin foulant layers is often limited by manual processing and ... |
41744693 | Innovative Fatty Acid-Guided Biosensor Design for Neutrophil Gelatinase, a Prognostic and Diagnostic Biomarker for Chronic Kidney Disease. | Chronic kidney disease (CKD) afflicts 850 million people worldwide, with an estimate that it is the 5th highest cause of years of life lost (YLLs). Standard confirmatory procedures for disease are blood and urine analysis with ultrasound for confirmation. Neutrophil gelatinase-associated lipocalin (NGAL) has been estab... |
41696589 | Upgrading pillar[<i>n</i>]arenes to reversible photocontrolled self-folding hosts for photoswitchable guest uptake/release and self-assembly. | Photoresponsive macrocycles can serve as versatile supramolecular platforms for exploring remote-controllable self-assembly systems and materials. However, reconciling excellent host-guest properties with robust photocontrollable capabilities persists as a formidable yet pivotal challenge in the design and construction... |
41696591 | Porous alloying-type particles for practical lithium-ion battery anodes. | Li-alloying-type anodes (Si, Sn, Ge, <i>etc.</i>) are potential candidates for high-energy lithium-ion batteries (LIBs), offering outstanding Li-storage capacity. However, their practical use is hampered by severe volume fluctuations during cycling, which lead to particle pulverization, an unstable interphase, and thus... |
41696341 | Size Adjustment of Zinc Oxide Nanostructures by Ultrasmall TiO<sub>2</sub> Nanoparticles. | The interaction of positively charged ZnO nanorods (<i>nr</i>-ZnO) with negatively charged ultrasmall amorphous titanium dioxide (<i>am</i>-TiO<sub>2</sub>) nanoparticles (NPs) induced a decrease in the <i>nr</i>-ZnO particle size while forming nanostructured core@shell <i>x</i>ZT materials (Zn/Ti molar ratios of 16, 8... |
41696334 | The Study on the Capacitive Properties of Tungsten Oxide/Graphene Composites Prepared by Ultrasonic Spray Deposition. | The fabrication of tungsten oxide/graphene thin films on fluorine-doped tin oxide (FTO) glass substrates using ultrasonic spray deposition technology is presented, and their potential application as supercapacitor electrode materials is explored. Ultrasonic spray deposition provides precise control over film thickness,... |
41696298 | Investigating the Mechanisms of <i>Prunella vulgaris</i> against Acute Lymphoblastic Leukemia through Network Pharmacology and Experimental Validation. | <h4>Objective</h4>This study investigates the underlying mechanisms of <i>Prunella vulgaris</i> on apoptosis in acute lymphoblastic leukemia (ALL) cells using an integrated approach that combines network pharmacology, molecular docking, and cellular experiments.<h4>Methods</h4>Active ingredients of <i>P. vulgaris</i> a... |
41696261 | Balancing Efficiency, Stability, Scalability, and Sustainability in Hybrid Perovskite Solar Cells: A Comprehensive Review. | Hybrid perovskite solar cells (PSCs) have rapidly advanced, achieving power conversion efficiencies above 27%, yet their widespread commercialization remains constrained by intrinsic and extrinsic stability issues. Recent developments in device engineering, module integration, and material composition tuning have impro... |
41696260 | Comparing the Nitration of Nanostructured CNF and Other Cellulose Forms for Energetic Applications. | This work focuses on the nitration of nanocellulose to obtain products with potential advantages over traditional ones obtained from linter cellulose (LC). The material used was a sample of cellulose nanofibrils (CNF) commercially available as an aqueous suspension with a 3% solid content. The main objective of the res... |
41696257 | Mechanical Stability and Binder Interaction in MOF Composites: An Integrated Experimental and DFT Study. | An integrated study combining experimental methods and DFT simulations was undertaken to investigate the binder/MOF composites. The findings demonstrate a strong correlation between the crush strength and surface adsorption energy of methylcellulose (MC) on HKUST, ZIF-8, UiO-66-(Zr), and MIL-53-(Al)-TDC surfaces. Exper... |
41696247 | Reading between the Chains: Surface Mapping and Druggable Pockets on the Biological Assemblies of DENV-2's Protein E. | Dengue is a widespread arboviral infection endemic to tropical and subtropical regions, representing a major global public health concern. Although most prevalent in South America and Asia, cases have also emerged in Europe and the United States, including instances of local transmission and fatalities. The envelope pr... |
41683659 | Aquaporin-4 Dysfunction in Depression: From Pathogenic Mechanisms to Novel Therapeutic Targeting. | Depression represents a leading cause of global disability, yet its pathogenesis remains incompletely understood. This review synthesizes emerging evidence highlighting the multifaceted role of Aquaporin-4 (AQP4), the central nervous system's predominant water channel, in the pathophysiology of depression. Preclinical ... |
41683666 | Temperature Dependence of a Thermosensitive Nanogel: A Dissipative Particle Dynamics Simulation of PNIPAM in Water. | Thermosensitive nanogels undergo a volume phase transition in response to temperature changes, making them promising candidates for applications, such as water pollutant remediation and drug delivery. In this study, we investigated the thermosensitive volume phase transition of a neutral poly(N-isopropylacrylamide) (PN... |
41683406 | Interpreting the Theranostic Applications of Alumina and Silica Substrates in Cancer. | In recent years, remarkable progress in nanomedicine has been achieved, leading to the development of several nanocarriers which aim to enhance the therapeutic efficacy in cancer treatment. Owing to their high versatility and highly tunable physicochemical properties, alumina (Al<sub>2</sub>O<sub>3</sub>) and silica (S... |
41683398 | Importance and Involvement of Imidazole Structure in Current and Future Therapy. | Imidazole is, from a structural point of view, a heterocycle consisting of three C atoms and two N atoms, belonging to the class of diazoles, having two N atoms at the first and third positions in the aromatic ring. Being a polar and ionizable aromatic compound, it has the role of improving the pharmacological properti... |
41683397 | Deep Eutectic Solvents as Green Media for Catalyst Synthesis in Advanced Oxidation Processes. | At present, the contamination of wastewater by persistent organic pollutants is a problem causing significant concern. Advanced oxidation processes have emerged as effective and innovative technologies for the degradation of these pollutants. In these processes, the synthesis and usage of an appropriate catalyst is ess... |
41683401 | Phenanthrene-like Benzodichalcogenophenes: Synthesis, Electrochemical Behavior and Applications. | Benzodichalcogenophenes represent a valuable class of organic π-conjugated systems that have been investigated in a plethora of cutting-edge applications in the field of materials chemistry. Isomeric benzodifuran (<b>BDF</b>), benzodithiophene (<b>BDT</b>) and benzodiselenophene (<b>BDS</b>) analogs of phenanthrene, in... |
41683231 | Multi-Omics and Molecular Docking Reveal That Oats and Oat Bran Alleviate Chronic Colitis Via IL-17 Pathway Modulation. | <h4>Background/objectives</h4>Diet plays a critical role in the development of inflammatory bowel disease (IBD). Our previous work demonstrated that oats and oat bran alleviate dextran sulfate sodium (DSS)-induced colitis in mice by modulating the gut microbiota.<h4>Methods</h4>To further explore the underlying mechani... |
41682041 | Architecting Functional Polymers: Advances in Modular Synthesis, Responsive Design, and Multifaceted Applications. | The recent development in polymer science has gone beyond the traditional linear and randomly functionalizable macromolecules to the architected polymer systems, which integrate modular synthesis and dynamic responsiveness. Although the literature related to polymer synthesis and stimuli-responsive materials and applic... |
41681851 | Spectroscopic Studies of the Modulation of Metabolic Activity of HBE Cells by Doxorubicin Hydrochloride-Loaded SW480-Derived Exosomal Nanocarriers. | Colorectal cancer (CRC) is one of the most common and fatal cases of cancer in the world [...]. |
41681546 | <i>CaCBP2</i> Negatively Regulates Pepper Resistance to <i>Phytophthora capsici</i> Infection. | Research on the CBP gene family in plants is scarce, with only sporadic reports on its association with immune responses. No systematic study has explored how CBP family genes regulate pepper resistance against <i>Phytophthora capsici</i>. Here, we focused on pepper <i>CaCBP2</i>, an RNA-binding protein, whose expressi... |
41681182 | Design of Multifunctional SC-PLA Pesticide Carrier System and Study of Controlled-Release Performance. | To construct a high-performance avermectin (Avm) carrier system, this study utilized the advantages of stereocomplex (SC) crystal formation between poly (L-lactic acid) (PLLA) and poly (D-lactic acid) (PDLA) to prepare Avm-loaded stereocomplex polylactic acid (SC-PLA) nanoformulations via the emulsion solvent evaporati... |
41677600 | Sweet Surprises: Decoding Tumor-Associated Glycosylation in Cancer Progression and Therapeutic Potential. | Tumor-associated glycosylation is a defining hallmark of cancer, exerting profound effects on multiple aspects of tumor biology. This phenomenon arises from the central role of glycosylation in a wide range of cellular processes and its inherently diverse structural complexity. In cancer cells, aberrant glycosylation o... |
41677601 | Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the viral spike proteins, which are key structural components that mediate host cell binding and entry and alter downstream signaling through multiple interactions with endothelial surface receptors. Endothelial dysfunction is a cent... |
41677518 | Design and Application of Fluorescence Probes for Gold Nanocage Complex Perovskite Quantum Dots. | In this study, a gold nanocage composite perovskite quantum dot fluorescent probe (MB-GNCs-PQDs) was designed and constructed. The GNCs-PQDs composite system was formed by the combination of gold nanocages (GNCs) and perovskite quantum dots (PQDs). Spectral analysis confirmed that its fluorescence intensity was signifi... |
41675416 | Diketo[<i>n</i>]CPPs as chiral and shape-adaptive fullerene hosts and precursors to DBP[<i>n</i>]CPPs. | Conjugated nanohoops, such as [<i>n</i>]cycloparaphenylenes ([<i>n</i>]CPPs) and derivatives, exhibit unique structural and optoelectronic properties, making them promising candidates for applications in optoelectronic materials, and as hosts for supramolecular chemistry. Using π-systems unsymmetric to rotation or inco... |
41674689 | Effects of (-)-Epigallocatechin-3-gallate non-covalent binding on the functional and structural properties of pumpkin seed protein isolate. | Pumpkin seed protein isolate (PSPI), an emerging plant-based protein, has attracted attention, but more exploitation is needed to unlock its potential. To investigate whether (-)-Epigallocatechin gallate (EGCG) could improve PSPI properties, physicochemical and interaction analyses were conducted. Results showed EGCG s... |
41669682 | Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk. | <h4>Introduction</h4>Rhein, an anthraquinone derived from rhubarb, exhibits renoprotective effects in aging and kidney injury; however, the mechanistic interplay with TNF-α-mediated cell death pathways remains undefined.<h4>Methods</h4>Using D-galactose (D-gal)-treated NRK-52E cells and aged rats, we assessed rhein's e... |
41669267 | Radiation-induced skin injury: a review of pathophysiology, assessment, management, and re-irradiation protocols. | <h4>Background</h4>Radiation-induced skin injury (RISI) is a common dose-limiting toxicity of radiotherapy, characterized by erythema, desquamation, fibrosis, atrophy, and ulceration. It results from DNA damage, reactive oxygen species, and dysregulated inflammation.<h4>Purpose</h4>This review synthesizes current knowl... |
41669081 | Ursodeoxycholic acid alleviates high-fat diet-induced liver injury by modulating gut microbiota-mediated bile acid metabolism: an integrated microbiota-metabolomics analysis. | <h4>Purpose</h4>Ursodeoxycholic acid (UDCA), a naturally occurring bile acid with established hepatoprotective properties, has garnered attention for its potential role in metabolic health. This study provides scientific validation for these traditional uses by demonstrating UDCA's protective mechanisms against non-alc... |
41668976 | Structure-guided engineering of prototype foamy virus Env identifies key residues for heparan sulfate binding and enhances transduction efficiency. | <h4>Objective</h4>Prototype foamy virus (PFV) is an attractive gene delivery platform due to its large cargo capacity and favorable safety profile; however, the structural basis of its interaction with heparan sulfate (HS), a critical attachment factor for viral entry, remains undefined. The objective of this study was... |
41668888 | Emerging roles of protein modifications in sexual reproduction and pathogenesis of filamentous fungi. | Posttranslational modifications play pivotal roles in the regulation of protein function, enabling precise and dynamic control of diverse cellular processes in fungi. Classical and emerging PTMs, such as phosphorylation, ubiquitination, acetylation, lysine succinylation, and SUMOylation, glycosylation, lipidation modif... |
41668765 | Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome. | This manuscript reviews the current evidence describing the relationships between surgical trauma, altered intestinal permeability, dysbiosis, inflammasome activation, and postoperative inflammation in the development of AL. Surgical tissue disruption and anastomosis creation can modify the intestinal microbiota and co... |
41668757 | Stimuli-responsive nanoplatforms for precision activation of the STING pathway in cancer immunotherapy. | The stimulator of interferon genes (STING) pathway plays a unique role in antitumor immunity, bridging innate and adaptive immune responses to initiate a sustained and highly effective antitumor immune response. However, due to the widespread expression of the STING pathway and the lack of clearly distinguishable physi... |
41668751 | Structural-activity relationship of <i>Lycium barbarum</i> polysaccharides in immunomodulation: integrating molecular insights with target identification for therapeutic development. | The immunomodulatory potential of <i>Lycium barbarum</i> polysaccharides (LBP) is well-established, yet the intricate structure-activity relationships (SAR) underlying these effects require clarification to advance therapeutic applications. This review synthesizes current knowledge on how specific structural parameters... |
41668731 | Multi-omics profiling reveals associations between gut microbiota and olfactory gene expression in mosquitoes. | <h4>Introduction</h4>The interplay between gut microbiota and host physiological processes has been extensively studied in vertebrates, where it plays a crucial role in regulating appetite, emotion, immunity, and other physiological functions. However, whether a similar regulatory mechanism exists in insects remains un... |
41659256 | Efficacy and mechanisms of cisplatin and sulforaphane nanoparticles in alleviating cisplatin resistance in non-small cell lung cancer. | <h4>Background</h4>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and its morbidity and mortality rates continue to increase, placing tremendous pressure on global public health systems. Cisplatin (DDP), also known as diamminedichloroplatinum (II), is a traditional chemotherapy drug widely u... |
41659006 | Aggregation Tendency, Cellular Uptake, and Viability Effects of Structurally Distinct Carbazole-Phthalocyanine Gold Nanoconjugates. | Phthalocyanine-gold nanoparticle (Pc-AuNP) conjugates combine the unique properties of gold with the therapeutic potential of phthalocyanines, offering a promising strategy for cancer therapy. Here, two novel carbazole-containing Pcs, axially disubstituted Si-(IV) and peripherally tetra-substituted Zn-(II) derivatives,... |
41650540 | Phosphated maltodextrin as an anionic chiral selector for capillary electrophoresis: Application to the enantiomeric separation of basic drugs. | Chiral separation is critical in pharmaceutical analysis, as enantiomers often exhibit distinct pharmacological activities, metabolic behaviors, and toxicity profiles. Cyclodextrins have been widely employed in capillary electrophoresis (CE) owing to their well-defined cavities and strong inclusion capabilities that fa... |
41633295 | Molecular-recognition architectures and emerging probe strategies for neurotransmitter chemical sensing. | Monitoring neurotransmitter dynamics in the brain with high spatial and temporal fidelity is essential for understanding neural circuit function and dysfunction. Although detection technologies have advanced, the molecular recognition elements that initiate sensing still largely define selectivity, speed, and in vivo p... |
41619613 | Covalent organic framework@metal-organic framework nanohybrid as ratiometric fluorescence sensor for ciprofloxacin determination. | Ciprofloxacin (CIP) is an effective and widely used antibiotic against various bacterial infections. However, its excessive presence in the environment and animal-derived food products poses significant risks to human health and ecological systems. Therefore, the development of sensitive, selective, and reliable detect... |
41605285 | OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte. | <h4>Introduction</h4>Demyelination is associated with behavioral disorder and cognitive impairment in neuropsychiatric diseases, including major depressive disorder (MDD). However, the mechanism underlying myelin damage remains unclear, despite stress maybe a major risk factor.<h4>Objectives</h4>Here, we demonstrate th... |
41616631 | MOF-199/graphene aerogel-derived porous carbon as solid-phase microextraction coating for the highly sensitive determination of phthalate acid esters in condiments. | Phthalate acid esters (PAEs) are ubiquitous pollutants in food, necessitating accurate detection to ensure food quality and safety. Herein, a novel MOF-199/graphene aerogel composite-derived porous carbon material (MGC) was successfully fabricated and applied as a solid-phase microextraction (SPME) coating for the effi... |
41608076 | In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP-40. | The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus. We retrieved antiviral peptides from the AVPdb and de... |
41602480 | A Novel Dual-Functional Photomultiplication-Type Organic Photodetector with Photon-Regeneration Gain by Integrated Organic Light-Emitting Diodes. | Because of their outstanding weak light detection ability, multiplication-type photodetectors have great application prospects in fields such as environmental detection, biological science, and night vision imaging. Traditional photomultiplication-type organic photodetectors (PM-OPDs) usually achieve a large external q... |
41602192 | Multimodal investigation of dacomitinib-calf thymus DNA binding interaction: insights from spectroscopy, thermodynamics, and <i>in-silico</i> studies. | Dacomitinib is a second-generation tyrosine kinase inhibitor (TKI) used as a first-line targeted therapy for patients with metastatic non-small cell lung cancer. In this study, its interaction with calf thymus DNA (ctDNA) was systematically investigated using UV-Vis spectrophotometry, spectrofluorimetry, viscosity meas... |
41602198 | Design and fabrication of a zero-bias visible light photodetector based on a coumarin-derived Schiff base thin film. | A self-powered visible-light photodetector was fabricated using a coumarin-derived Schiff base, 4-FMCSB, as the active layer. The compound was synthesized <i>via</i> a two-step process and characterized using FT-IR, NMR, MALDI-TOF-MS, and UV-vis spectroscopy. The optical band gap of 4-FMCSB was determined to be 2.33 eV... |
41602183 | Intravital microscopy for nanomedicine: investigating nanoparticle-tissue interactions in the native state. | Nanomedicine is an evolving field that employs nanoparticles (NPs) for drug delivery systems, molecular imaging, and therapeutic interventions. However, characterizing NP-cell interactions poses significant challenges, mainly due to the limitations of traditional postmortem histological methods, such as immunofluoresce... |
41602191 | pH-responsive hyaluronic acid-<i>co</i>-poly(acrylic acid) hydrogel scaffolds for modified release of mesalamine; characterization and biosafety evaluation. | The current study focuses on the development of pH-sensitive hydrogels for the controlled release of mesalamine at a specific pH. A free radical polymerization technique was used, and the formulated hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis, scanning elec... |
41602185 | Enzyme therapy as a promising strategy to overcome multi-drug resistance in pathogens: current advances, key challenges, and future directions. | Multi-drug resistance (MDR) poses a serious threat to global health due to increasing death rates, as antibiotics are rendered ineffective, resulting in fatal infections as an outcome of treatment failures, which make them cost-ineffective in the healthcare sector. The excessive use of antibiotics in therapies for huma... |
41602175 | Optimization, thermo-oxidative stability, and biological activities of vitamin E-chitosan-TPP nanoformulations. | Enhancing stability is a crucial factor in selecting bioactive compounds in most applications, while encapsulation techniques have proven to be a promising solution. Despite the critical applications of α-tocopherol (α-TQ) in the food and pharmaceutical industries, it is easily degraded by heat and oxidized by various ... |
41602180 | Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking. | Thienopyrimidines represent an important class of nitrogen- and sulfur-containing heterocycles with broad pharmacological relevance. In this work, a new series of thienopyrimidine derivatives was efficiently synthesized through a multistep route involving cyclization, Mannich annulation, Schiff-base condensation, dipyr... |
41588788 | Chemo-Enzymatic Route for Covalent Cellulose Fiber Dyeing. | The conventional textile dyeing process, based on reactive dyes, allows covalent dye fixation but requires toxic or hazardous chemicals that raise significant environmental pollution and health concerns. In this study, we present a proof-of-concept, two-step chemo-enzymatic process for grafting aminated dyes onto cotto... |
41588743 | Interfacially Coupled and Synergistic Effect of Ag/Co<sub>3</sub>O<sub>4</sub>-C Nanocomposites for Enhanced Oxygen Reduction (ORR) and Evolution (OER) Reaction. | Overpotentials associated with the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) remain key challenges hindering the practical deployment of advanced electrochemical energy conversion technologies such as alkaline fuel cells. While Pt/C demonstrates excellent ORR activity, its sluggish OER kinetic... |
41588692 | Wearable Cooling Textiles of Thermal Conduction and Sweat Transfer for Personal Thermal Management. | Given rising global temperatures, advanced protective textiles hold significant potential to enhance productivity, conserve energy, and improve personal thermal comfort. Extensive research has shown that both thermal conduction and moisture management are equally critical in determining the comfort performance of texti... |
41588612 | A Hooker Oxygenase Archetype in Polyketide Biosynthesis Challenging the Baeyer-Villiger Monooxygenase Paradigm. | Aromatic polyketides from Actinobacteria are structurally complex bioactive natural products with significant therapeutic potential, whose biosynthesis involves polyketide chain assembly, keto reduction, cyclization, and aromatization. This is followed by pathway-specific enzymatic tailoring steps, occasionally includi... |
41588462 | Exosomes-loaded with traditional Chinese medicine constituents: a novel therapeutic avenue for aplastic anemia. | Aplastic anemia (AA) is a life-threatening blood disorder characterized by bone marrow failure and pancytopenia. Treatments such as immunosuppressive therapy (IST) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) have limitations, including poor long-term remission and donor shortages. Exosomes, nanos... |
41588452 | Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy. | The unique pathological microenvironment of periodontitis poses significant challenges to conventional therapies and drives the development of advanced treatment strategies. Engineered nanozymes as multifunctional nanomaterials offer promising alternatives for actively modulating disease microenvironments. Compared wit... |
41588428 | Inflammation-responsive biomimetic hybrid nanovesicles reverse stem cell senescence by up-regulating SIRT1 to treat periodontitis. | Periodontitis is a chronic inflammatory condition affecting billions globally, posing a significant public health challenge due to its high prevalence and associated tooth loss. The inflammatory microenvironment engendered by periodontitis can induce cellular senescence and functional impairment in critical reparative ... |
41588398 | Migrasomes constrained by a homologous-targeting photodynamic nanoplatform: enhancing intratumoral CD8<sup>+</sup> T-cell-associated antitumor immunity in oral squamous cell carcinoma. | Photodynamic therapy (PDT) is an effective adjunct treatment for oral squamous cell carcinoma (OSCC). Enhancing photosensitizer targeting and inducing effective cytotoxic T-cell responses through photoimmunotherapy have become key strategies to improve PDT efficacy. Migrasomes, as vesicular structures assembled by TSPA... |
41588372 | Targeted paclitaxel delivery in ovarian cancer via AP1-functionalized elastin-like polypeptide nanocarriers: development and characterization. | Paclitaxel has been a cornerstone of ovarian cancer chemotherapy for over two decades. However, its clinical application is constrained by poor solubility and non-specific delivery, resulting in systemic toxicity and inconsistent therapeutic outcomes. Nanotechnology-based drug delivery systems have emerged as a promisi... |
41588170 | Scalable and multiplexed recorders of gene regulation dynamics across weeks. | Gene expression is dynamically controlled by gene regulatory networks comprising multiple regulatory components to mediate cellular functions<sup>1</sup>. An ideal tool for analysing these processes would track multi-component dynamics with both spatiotemporal resolution and scalability within the same cells, a capabil... |
41587994 | Portable and label-free optical detection of sweat glucose using functionalized plasmonic nanopillar array. | Continuous glucose monitoring (CGM) is vital for diabetes care, but current invasive electrochemical sensors of blood glucose often cause potential infection and skin irritation. Non-invasive sensors in sweat glucose are promising alternatives but limited by low sensitivity and poor compatibility with complex sweat env... |
41587995 | Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications. | Cytotoxic T lymphocytes play a crucial role in anti-tumour immunity, with granzyme B (GrB) being a decisive factor in this process. Developing a GrB-based delivery system to mimic T cell-based immunotherapy holds promise but remains challenging. Here, we present an artificial metalloenzyme (nanozyme) with GrB-like prot... |
41587976 | YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice. | The evolution of SARS-CoV-2, coupled with its immune evasion mechanisms, underscores the urgent need for antiviral strategies beyond vaccination. The papain-like protease (PL<sup>pro</sup>) is a dual-functional enzyme essential for viral replication and suppression of host innate immunity. Here, we present the rational... |
41587977 | Mechanical forces from intercellular peptide self-assembly drive spheroid formation. | This work presents a general strategy for engineering cell spheroids with capillary-like structures using intercellular self-assembly of peptide nanofibers. These nanofibrous materials induce mechanical changes in the extracellular matrix (ECM), activate mechanotransduction pathways, and enhance cellular morphogenesis,... |
41587972 | Ultra-stretchable and crack-resistant nonpolar organogels. | The inherent low polarity and weak intermolecular interactions of nonpolar media impose a fundamental thermodynamic constraint on gelation. Despite recent breakthroughs in designing highly stretchable and tough hydrogels, developing organogels that absorb nonpolar organic liquids with comparable mechanical performance ... |
41587970 | Krypton/Xenon separation at room temperature in a flexible coordinative framework sorbent. | The separation of xenon from krypton holds significant importance across various fields, including high-tech industries, national defence, and aerospace. Adsorptive separation via porous solids is considered one of the most promising alternatives to conventional energy-intensive cryogenic processes. While traditional a... |
41587965 | Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging. | Osteoarthritis (OA) is a degenerative skeletal condition marked by the loss of articular cartilage and changes to subchondral bone homeostasis. Treatments for OA beyond full joint replacement are lacking primarily due to gaps in molecular knowledge of the biological drivers of disease. Mass Spectrometry Imaging (MSI) e... |
41587975 | Intranasal administration of broad-spectrum macrocyclic peptide inhibitor protects against SARS-CoV-2 Omicron variants. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause significant morbidity and mortality despite the end of its pandemic phase. The emergence of highly mutated SARS-CoV-2 variants of concern highlights the requirement of broad-spectrum antiviral countermeasures which possess both prophylactic... |
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