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41587959 | PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes. | Invasion of erythrocytes by members of the Plasmodium genus is an essential step of the parasite lifecycle, orchestrated by numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms the essential PCRCR complex which binds basigin on the erythrocyte surface. Rh5 is restr... |
41587958 | 1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis. | It is thought that polysaccharides cannot penetrate the intestinal mucosa into the circulatory system due to their high hydrophilicity and large molecular size. However, we show that different linked and charged polysaccharides can penetrate Caco-2 cell monolayers, and find β-1,3-linked glucan and α-1,4-linked glucan i... |
41587942 | Depolymerization-Induced Morphological Transformation. | Depolymerization offers a powerful route for the chemical recycling of vinyl polymers. However, current strategies focus almost exclusively on monomer recovery, which overlooks broader applications and opportunities. Herein, depolymerization-induced morphological transformation (DIMT) is introduced as a modular methodo... |
41587935 | Acetylation-Tagging-Assisted Cocrystallization of Stubborn Molecules with Trinuclear Complexes. | Crystallographic analysis has become the most reliable method for elucidating the chemical structures and absolute configurations of natural products. In this study, we present an <i>in situ</i> acetylation-tagging approach to enable the cocrystallization of difficult-to-crystallize molecules bearing hydroxyl or amino ... |
41587927 | DNA-Driven Liquid-Liquid Phase Separation from Cellular Condensates to Programmable Synthetic Systems. | Liquid-liquid phase separation (LLPS) compartmentalizes biological systems into dynamic, membraneless condensates that regulate diverse cellular functions. Although protein and RNA-mediated LLPS have dominated research, DNA increasingly emerges as an active driver of phase separation rather than a passive structural sc... |
41587920 | Dual Topology States in Two-Dimensional Buckybowl Supramolecular Crystal of Sumanene. | Bowl-shaped polycyclic conjugated aromatic hydrocarbons have received tremendous attention because of their structural diversity and potential functionalization of their derivatives in fields such as spintronics, energy storage, etc. However, the topological electronic states of these organic buckybowl sumanenes have b... |
41587896 | Regulating π-Stacked Micelle-Like Assembly via Anion Coordination to Achieve Frank-Kasper C15 Phases. | Spherical surfactant micelles, widely used as templates for synthesizing porous inorganic materials, suffer from undeterminable atomic-level structures. Developing structurally precise spherical micelle-like architectures is therefore highly beneficial for understanding template syntheses yet remains challenging. Here,... |
41587897 | Recombinant Human IgG1 Enhances Complement-Mediated Bacteriolysis and Macrophage Phagocytosis of <i>Pseudomonas aeruginosa</i> via Targeting Cell Surface Polysaccharides. | The development of innovative therapeutics against WHO priority pathogens is an urgent global need. Here, we demonstrate the functionalities of a human antibody, previously isolated by whole cell biopanning of the phage display scFv library. The yPgi3G4 IgG1 could mediate antibody-dependent phagocytosis of <i>Pseudomon... |
41587307 | Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer. | Some mammals develop amyloid plaques and type 2 diabetes, much like humans, depending on the sequence of their islet amyloid polypeptide (IAPP). In humans, IAPP forms a toxic oligomer with a parallel β-sheet across residues <sup>23</sup>FGAIL<sup>28</sup>S. Using two-dimensional infrared spectroscopy, we monitor the st... |
41587300 | Temperature-Responsive Xylene Isomer Separation via Biomimetic Window Confinement and Defect-Engineered Nanospace in Metal-Organic Frameworks. | Biological channels achieve remarkable selectivity by amplifying subtle molecular differences through nanoscale confinement and steric gating. Inspired by this principle, we investigate the zirconium fumarate framework MOF-801, whose triangular pore windows act as biomimetic steric filters that preferentially accommoda... |
41587224 | HCMV encoded UL84 hijacks FHL2 to suppress type I interferon production and enhance viral replication. | Virus infection activates the host's innate immune responses, which is a very precise and complex biological process and will lead to the immediate transcription of type I interferon. The general transcriptional activator proteins such as IRF3, ATF2/c-Jun, and NF-κB can be induced to form a stable enhanceosome in the t... |
41587221 | De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli. | Extraintestinal Escherichia coli (ExPEC) proliferates rapidly in the bloodstream, causing life-threatening systemic infections with high mortality rates. Understanding how ExPEC adapts to the blood environment is essential for elucidating its pathogenesis and identifying potential antimicrobial targets. Using transposo... |
41587213 | Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. | Lumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) expressing both mCherry and luciferase reporters for high-throughput drug screeni... |
41587178 | Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells. | Interferons (IFNs) are potent antiviral cytokines that are rapidly activated when infected cells sense a virus, but continued IFN production following acute infection is linked to impaired recovery. IFNs protect against infection by inducing a suite of antiviral effectors in IFN receptor-expressing cells via JAK/STAT s... |
41587116 | Binding Site Vectors Enable Mapping of Cytochrome P450 Functional Landscapes. | Understanding similarities between protein binding sites has long been of great interest, as such comparisons can reveal functional relationships that transcend sequence or fold. However, systematic comparison remains challenging due to the difficulty of defining active sites consistently and developing descriptors tha... |
41587112 | Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling. | Polyester plastics have become integral to modern life due to their favorable physicochemical properties, cost-effectiveness, and broad industrial applicability. Unfortunately, the growing consumption and disposal of polyesters have led to mounting concerns regarding the corresponding carbon emissions and persistent po... |
41587001 | Evaluation of the antivirulence and anticancer potential of green-synthesized silver/zinc oxide nanocomposites against methicillin-resistant Staphylococcus aureus and melanoma cells. | The escalating incidence of methicillin-resistant Staphylococcus aureus (MRSA) necessitates novel therapeutic strategies targeting antibiotic resistance and biofilm formation. Silver/zinc oxide nanocomposites (Ag/ZnO NCs) were green-synthesized using Pistacia atlantica leaf extract. Comprehensive characterization confi... |
41586973 | Bioinspired Self-Assembly-Reinforced Ion Transport and Interface Regulation Enables Sustainable Metal-Ion Batteries for Wearable Electronics. | The rapid growth of wearable electronics demands power sources that are not only flexible and durable but also inherently safe. Conventional lithium-ion batteries pose safety risks due to toxic and flammable electrolytes. Aqueous metal-ion batteries offer a promising alternative, yet their application remains limited b... |
41586968 | Wafer-Level Self-Assembly and Interface Passivation Patterning Technology for Nanomaterial-Compatible 3D MEMS Sensing Chips. | Wafer-scale fabrication of high-performance micro-electro-mechanical systems (MEMS) bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into suspended MEMS architectures. Here, a wafer-level manufacturing strategy is presented that redefines t... |
41586900 | The role of HMGA1 in genome stability: Implications in human cancer. | High mobility group A1 (HMGA1), a non-histone chromatin structural protein encoded by the HMGA1 gene, plays a critical role in cancer. Recent studies have increasingly focused on its functions in genomic stability and cell death, revealing its involvement in tumorigenesis, cancer progression, and chemotherapy resistanc... |
41586895 | Urease-driven nanomotors loaded with sorafenib for magnetically-guided accumulation and deep tissue penetration towards hepatocellular carcinoma therapy via ferroptosis induction. | Hepatocellular carcinoma (HCC), accounting for 75-85% of liver cancers, faces limited therapeutic efficacy due to late-stage diagnosis, high malignancy, and poor drug permeability. Sorafenib (SF), a first-line multi-kinase inhibitor for unresectable HCC, suffers from low tumor-targeting efficiency and adverse effects. ... |
41586782 | Self-Assembly of Chiral Metal-Organic Helicates and Enhancement of Chiroptical Properties via Subcomponent Modulation. | We report three chiral metal-organic helicates (MOHs) constructed through the self-assembly of anthracene-based aldehyde precursors, chiral amino precursors with different groups ((<i>R/S</i>)-1-phenylethanamine, (<i>R/S</i>)-1-(1-naphthyl)ethylamine, or (<i>R/S</i>)-1-(2-naphthyl)ethylamine), and Zn<sup>2+</sup> ions.... |
41586727 | Spectral Fingerprinting of Engineered Nanomaterials for Precision Biosensing. | Biological systems comprise a complex milieu of macromolecules, small molecules, and ions comprising tens of thousands of distinct species. Various clinical conditions alter the identities and concentrations of these species in a spatiotemporal-dependent manner. While bioanalytical methods such as omics or biochemical ... |
41586499 | Combination therapy with tobevibart and elebsiran potently reduces hepatitis B virus surface antigen levels in preclinical <i>in vivo</i> models. | RNA interference (RNAi) therapeutics targeting hepatitis B virus (HBV) RNAs and monoclonal antibodies (mAbs) targeting HBV surface antigen (HBsAg) represent potential strategies for enabling functional cure in chronic HBV patients. Tobevibart (VIR-3434) is an investigational, Fc-engineered human mAb that targets HBsAg ... |
41586992 | Microenvironment-Engineered Biocatalytic Metal-Organic Framework Nanomotors for Selective and Transformative Water Decontamination. | Catalytically powered micro-/nanomotors have become a compelling alternative to conventional catalysts for active and efficient removal of environmental pollutants in water remediation. We developed a novel biocatalytic nanomotor system by encapsulating catalase and peroxidase enzymes into metal-organic frameworks (MOF... |
41586460 | Helical Aromatic Oligoamide Macrocycle Incorporated with a Ferrocene Unit for Encapsulation and Chirality Signaling of Zwitterionic Proline. | A strategy for developing ferrocene-incorporated heteroditopic macrocycles for the recognition of zwitterionic proline is presented. The receptor features a well-defined helical cavity, and diastereomeric conformers result upon encapsulation of d/l-proline as indicated by X-ray crystallography. Incorporation of a ferro... |
41582789 | Ethanol-Guided Hybridization of Extracellular Vesicles with Liquid-Crystalline Lipid Nanoparticles. | Hybrid nanosystems that integrate biological and synthetic lipid assemblies hold great promise for tailoring nanoscale interfaces with programmable chemical and structural functionality. However, existing approaches to hybridize extracellular vesicles (EVs) with lipid nanoparticles (LNPs) compromise either the EV bioac... |
41582698 | Marine Bacterium <i>Kordia algicida</i> Reshapes Plankton Microbiome and Induces Metabolomic Rewiring, Independent of Heatwave or Worst-Case Climate Scenarios. | Marine bacteria are integral components of planktonic communities, where they regulate algal growth, induce cell death, and contribute to bloom termination and species succession. They also play a key role in marine biogeochemical cycling by recycling algal-derived organic matter and releasing bioactive metabolites. De... |
41582659 | Light-Induced Rotation of a Molecular Motor in the Confined Space of a Metal-Organic Nanocage. | Molecular motors have been operated in a myriad of environments since their inception more than two decades ago. Of particular interest are systems in which a structural frame of reference for the motor's rotary motion is established. Examples include motors adsorbed on surfaces, embedded in framework materials, used a... |
41582293 | Laser-Driven Single-Step Synthesis of Monolithic Prelithiated Silicon-Graphene Anodes for Ultrahigh-Performance Zero-Decay Lithium-Ion Batteries. | Silicon-based anodes offer a promising alternative to graphite in lithium-ion batteries (LIBs) due to significantly higher energy density. However, their practical application is limited by substantial volume expansion during lithiation, which causes structural instability and continuous formation of the solid electrol... |
41582262 | Integrated Performance Metrics of Porous Carbon Toward Practical Supercapacitor Devices. | The scientific communities in both academia and industry are devoted to increasing energy density of supercapacitor devices, including investigating the relationship between carbon structure and capacitance of various activated carbon (AC) materials. However, most reported capacitance values are measured solely at the ... |
41582238 | Suppressing electron-phonon coupling and energy loss in organic solar cells by modulating donor-acceptor penetrated-interface. | Organic solar cells (OSCs) achieve 21% efficiency, yet non-radiative energy loss (qΔV<sub>nr</sub>) remains a critical barrier to further improve the open-circuit voltage (V<sub>OC</sub>). This loss is primarily governed by the optoelectronic properties of interfacial CT states, yet the precise role of electron-phonon ... |
41582211 | Ensemble-learning-assisted exhaled gas disease analysis based on in-situ construction of MOF-derived MO<sub>x</sub>/GaN heterojunction sensor arrays. | Human exhaled gas is rich in biomarker information that could be used for early diagnosis of disease. With the development of nanotechnology and the Internet of Medical Things (IoMT), AI-assisted nano gas sensor arrays as a non-invasive exhaled gas detection platform brings fascinating technological solutions to the fi... |
41582195 | Anti-bacterial properties of hyperbranched poly (epsilon-lysine) peptides dendrons for wound dressing applications: molecular specie-specific effects. | <h4>Background</h4>Wound dressings, as tulles or hydrogels, are the devices of choice for the management of wounds and they are also made available to clinicians in formulations integrating silver nanoparticles as antibacterial agents. Nevertheless, the management of wounds is significantly affected by bacterial infect... |
41582163 | Rigid ionic-bonding networks boosting organic room temperature phosphorescence. | Ionic bonds possess excellent advantages in organic phosphorescence enhancement due to their intense electrostatic interactions, non-directional, and unsaturated characteristics. Nowadays, host-guest doping is the mainstream strategy for synthesizing room-temperature phosphorescent materials. While this strategy may su... |
41376472 | Dimensionally engineered MOF films for chemiresistive sensors. | Accurate detection of trace gases is essential across a wide spectrum of fields, including smart home technologies, healthcare diagnostics, environmental monitoring, and public safety. Chemiresistive sensors have emerged as highly attractive platforms owing to their real-time response, portability, and non-contact sens... |
41364452 | Biomimetic liposomes in drug delivery: from design mechanisms to applications. | Recent advancements in nanocarriers, particularly liposomes, have shown promising prospects for enhancing the pharmacokinetics, biodistribution, and therapeutic efficacy of chemotherapeutic drugs. However, liposome-based drug delivery systems are often constrained by high immunogenicity, poor targeting efficiency, and ... |
41257301 | Tailoring the dynamic nanocomposite hydrogels through surface-functionalized nanomaterials and interfacial crosslinking chemistry toward multifunctional biomedical and engineering applications. | Dynamic nanocomposite hydrogels (DNCHs) represent a cutting-edge class of materials characterized by their tunable architecture and stimuli-responsive behavior, making them particularly well-suited for applications that require mimicking the adaptive functionality of biological systems. A wide range of chemical strateg... |
41252716 | Single-molecule quantum tunnelling sensors. | Single-molecule sensors are pivotal tools for elucidating chemical and biological phenomena. Among these, quantum tunnelling sensors occupy a unique position, due to the exceptional sensitivity of tunnelling currents to sub-ångström variations in molecular structure and electronic states. This capability enables simult... |
41160636 | Pressure-driven interconversion between Ruddlesden-Popper and Dion-Jacobson phases in two-dimensional hybrid perovskites <i>via</i> supramolecular interactions. | Hybrid lead halide perovskites have emerged as versatile candidates for advanced optoelectronic applications. However, precise control over their phase interconversion remains challenging. Here, we report two structurally distinct 2D perovskites, <i>S</i>-[BPEA]<sub>2</sub>PbI<sub>4</sub> and <i>rac</i>-[BPEA]<sub>2</s... |
41114440 | Enhanced toughness in highly entangled hydrogels <i>via</i> non-covalent molecular hooks. | Hydrogels with enhanced toughness have received increasing attention due to their potential for load-bearing applications. Recent findings have demonstrated that highly entangled networks are capable of forming such materials, yet their fabrication generally necessitates a covalent cross-linker, limiting their processa... |
41797965 | Pathology-guided design of injectable hydrogels for precision therapy and cartilage regeneration in osteoarthritis. | Osteoarthritis (OA) is a highly prevalent degenerative joint disease whose complex pathological microenvironment and limited cartilage self-repair capacity have resulted in the absence of therapeutic approaches capable of simultaneously achieving structural reconstruction and functional recovery. Current clinical strat... |
41754899 | Advantages of the Combined Use of Cyclodextrins and Chitosan in Drug Delivery: A Review. | Cyclodextrins and chitosan are biomaterials largely used as pharmaceutical excipients due to their biocompatibility, biodegradability, and low/absent toxicity, associated with a number of favorable properties. In particular, cyclodextrins complexation is mainly utilized to improve the physicochemical and biological pro... |
41751507 | Cloning and Characterization of <i>IbHQT1</i>: A BAHD Acyltransferase Gene That Positively Regulates Chlorogenic Acid Biosynthesis in Sweet Potato. | <h4>Background</h4>Hydroxycinnamoyl-CoA quinate hydroxycinnamoyl-transferase (HQT) is an essential enzyme for chlorogenic acid (CGA) biosynthesis in plants. Multiple <i>HQT</i>-encoding genes potentially involved in CGA synthesis in sweet potato (<i>Ipomoea batatas</i>) have been predicted. However, the functions of th... |
41742995 | Unmasking Heterogeneity: Evaluating Distinct Sepsis Clinical Phenotypes and Their Association With Mortality in Critical Adult Patients. | <h4>Objective</h4>This study aimed to evaluate three phenotypic classifications based on their ability to predict mortality in critically ill adult patients with sepsis.<h4>Methods</h4>This single-center cohort study involved 106 patients diagnosed with sepsis upon admission to the intensive care unit (ICU). The patien... |
41746037 | Efficacy of Multivalent Dengue Vaccine Candidates Predicted In Silico. | <b>Background:</b> Dengue virus (DENV) is becoming a global public health problem, but the immunogenicity of DENV structural proteins is not fully understood. <b>Methods:</b> We predicted the epitope-based immunogenicity of DENV proteins from four serotypes in silico and evaluated their efficacy in vitro (T-cell prolif... |
41745726 | Field-Evolved Resistance to Bt Cry Toxins in Lepidopteran Pests: Insights into Multilayered Regulatory Mechanisms and Next-Generation Management Strategies. | Bt Cry toxins remain the cornerstone of transgenic crop protection against Lepidopteran pests, yet field-evolved resistance, particularly in invasive species such as <i>Spodoptera frugiperda</i> and <i>Helicoverpa armigera</i>, can threaten their long-term efficacy. This review presents a comprehensive and unified mech... |
41744690 | Probing Glycosaminoglycan-Protein Interactions: Applications of Surface Plasmon Resonance. | Glycosaminoglycans (GAGs) are highly negatively charged polysaccharides that play essential roles in numerous physiological and pathological processes through their interactions with proteins. These interactions govern cellular signaling, inflammation, coagulation, and recognition. Surface Plasmon Resonance (SPR) has e... |
41696304 | Environmentally Adaptive Vitrimer Adhesives: Enhancing Dismantlability and Recyclability by Introducing Polyrotaxane Networks. | Developing sustainable and multifunctional adhesives has become imperative in the context of circular materials and environmentally responsible manufacturing. Achieving a balance between high adhesion strength at ambient temperature and efficient dismantlability at an elevated temperature remains a central challenge in... |
41696280 | Reversible Hydrogen Storage Properties of Superalkali NLi<sub>4</sub>‑Decorated Inorganic Graphenylene SiC. | Hydrogen energy has the potential to substitute for fossil-based energy; however, the primary challenge is its effective storage materials. Taking this into consideration, utilizing the quantum chemical methods, superalkali NLi<sub>4</sub>-decorated inorganic graphenylene SiC (IGP-SiC) has been investigated to explore ... |
41696214 | Circular Permutation of the <i>E. coli</i> Heat-Labile Enterotoxin Pentameric B Subunit for Mucosal Vaccine Adjuvant Design. | The heat-labile enterotoxins (LTs) of <i>Escherichia coli</i> structurally belong to the AB<sub>5</sub> toxin, which consists of an A subunit and a pentameric B subunit. LTs have been extensively reported for their potent mucosal adjuvant activities. The B subunit of type II LT (LT-IIb-B<sub>5</sub>) recognizes the GD1... |
41683390 | Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids from <i>Gynura segetum</i>: Mechanisms and Therapeutic Advances. | The traditional Chinese medicinal herb <i>Gynura segetum</i> is increasingly recognized for its hepatotoxic potential, primarily attributed to its pyrrolizidine alkaloid (PA) content. PAs are a leading cause of herb-induced liver injury (HILI) in China and are strongly linked to hepatic sinusoidal obstruction syndrome ... |
41683388 | Black Gold in Medicine: Rediscovering the Pharmacological Potential. | This study explores crude oil as a chemically and structurally heterogeneous system with potential pharmaceutical relevance beyond its established roles as an energy and feedstock resource. Recent advances in analytical technologies have enabled the detailed characterization of crude oil constituents at the molecular l... |
41683026 | Deep Eutectic Solvent Ultrasonic-Assisted Extraction of Polysaccharides from Red Alga <i>Asparagopsis taxiformis</i>: Optimization, Characterization, Mechanism, and Immunological Activity in RAW264.7 Cells. | Traditional polysaccharide extraction suffers from low efficiency and high energy consumption, while deep eutectic solvents (DESs) are promising sustainable solvents. This study used DES ChCl-LA (1:2) with ultrasonic assistance to extract polysaccharides from red alga <i>A.</i><i>taxiformis</i>. Optimized via single-fa... |
41682029 | Electrochemical Characterization of a Molecularly Imprinted Polymer Sensor for the Selective Recognition of Type II Collagen in Joint Degeneration Monitoring. | Type II collagen is a primary fibrillar component of articular cartilage, and its early degradation is a key biomarker of joint-degenerative disorders such as osteoarthritis, rheumatoid arthritis, gout, etc. Reliable detection at low concentrations remains challenging due to limited assay accessibility, complex analyti... |
41681539 | Systematic Analysis of Reproductive Barrier Types and Strengths in Interspecific Hybridization Involving <i>Magnolia crassipes</i>. | <i>Magnolia crassipes</i> is a valuable species in <i>Magnolia</i> sect. <i>Michelia</i> known for its unique purple flowers, but interspecific reproductive barriers limit its use in breeding. Using <i>M. crassipes</i> as the maternal parent, we performed 13 pollination combinations (one selfed control and crosses with... |
41681360 | Effects of Newer Veterinary Macrolide Antimicrobials on the CYP3A-Dependent Metabolism in Cattle Liver Microsomes: Potential Metabolic Drug-Drug Interaction with Monensin. | Traditional macrolide antimicrobials are inhibitors of cytochrome P4503A (CYP3A) in cattle liver. Monensin (MON), an ionophore with a narrow safety margin, undergoes CYP3A-dependent O-demethylation, and its incompatibility with macrolides is well recognized in livestock animals. This study evaluated the effects of newe... |
41660118 | Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems. | Brain diseases are one of the most critical threats to human health. The blood-brain barrier (BBB) prevents drugs from entering the brain, rendering standard treatments for neurological illnesses ineffective. In recent years, there has been an increase in interest in nanotechnology-based research to develop innovative ... |
41605111 | A flexible composite electrode for effective real-time glucose monitoring via high-precision layer-by-layer inkjet printing. | Conventional techniques such as screen printing and hand-brushing, though scalable, often compromise on patterning resolution and material waste. In contrast, advanced inkjet printing offers a promising route for high-resolution and efficient manufacturing. In this study, a flexible electrode based on Ni-MOF material u... |
41604782 | Bio-responsive self-assembled nanoparticles of fatty acid prodrugs of sulfapyridine for the management of Rheumatoid arthritis. | Despite significant advancements in medical research, the treatment of rheumatoid arthritis (RA) is still challenging due to limitations associated with the conventional therapies, which include low tissue specificity, poor retention within inflamed joints, and systemic toxicity. Sulfapyridine (SP), a second-line drug ... |
41605082 | Zr-MOF boosted silver nanospheres for integrated SERS detection and solar photo-removal of hazardous contaminants. | In this study, Ag@NU-66 core-shell composites were synthesized by coating silver nanospheres with the metal organic framework (MOF)-UiO-66-NH₂ (Zr) using a straightforward hydrothermal technique. The resulting composite combines excellent stability, high enrichment capacity, and photocatalytic properties. As a SERS sub... |
41621318 | Structural and compositional changes in human milk proteins, lipids, and carbohydrates according to maternal metabolic profile: a multimodal characterization approach in a cohort of mothers from Northeastern Mexico. | Human milk (HM) contains key macronutrients (proteins, lipids, and carbohydrates) essential for infant development; however, compositional differences do not necessarily reflect equivalent structural properties. This study analyzed HM samples collected at 1 and 3 months postpartum from mothers with normal weight (NW), ... |
41611515 | [Identification of proteins binding to interacting homologous regions in <i>Bombyx mori</i> nucleopolyhedrovirus]. | The homologous regions (<i>hrs</i>) of <i>Bombyx mori</i> nucleopolyhedrovirus (BmNPV) have been demonstrated to function as transcriptional enhancers and initiation sites of DNA replication. This study aimed to elucidate the protein-binding characteristics of <i>hrs</i> in the BmNPV genome and their regulatory mechani... |
41611499 | [Identification of NHX gene family members in <i>Brassica juncea</i> and analysis of their expression patterns under salt stress]. | The NHXgenes encode Na<sup>+</sup>/H<sup>+</sup> transporters, which are cation/proton antiporters and play important roles in plant growth, development, and responses to abiotic stresses. To investigate the NHXgene family members in <i>Brassica juncea</i> and their relationship with salt tolerance, we utilized bioinfo... |
41602515 | Acute Myocardial Infarction in Pregnancy: A Multidisciplinary Approach. | Pregnancy is associated with increased hemodynamic demands on the mother's cardiovascular system. In a normal pregnancy, most women experience symptoms such as fatigue, dyspnea, lower extremity edema, and reduced exercise ability, which can be difficult to differentiate from those of cardiac malfunction. During pregnan... |
41582519 | Metal-Organic Framework and 5-Fluorouracil Co-Encapsulated Hyaluronic Acid/Carboxymethyl Chitosan Hydrogels for Synergistic Chemotherapy and Enhanced Chemodynamic Therapy. | A vitamin K3 (VK3)-loaded metal-organic framework (Cu/ZIF-8/VK3) was synthesized by a one-pot method. After the coencapsulation of Cu/ZIF-8/VK3 and 5-fluorouracil (5-FU) in the hyaluronate acid (HA)/carboxymethyl chitosan (CMCS) hydrogels formed via an amidation reaction, a drug-controlled release system (Cu/ZIF-8/VK3/... |
41582524 | Core-Shell MOF Heterostructure Films with Boosted Charge Trapping for High-Performance Triboelectric Nanogenerators. | Conventional triboelectric nanogenerators (TENGs) often suffer from limited charge transfer efficiency, restricting their practical integration into self-powered systems and on-demand energy storage units. To address this, we design a high-performance TENG based on an Ecoflex/GO-ZIF-8@ZIF-67 composite film (ZE-TENG), w... |
41582493 | A Tale of Two Folds: Multiorthogonal Interactions Driven Hierarchical Assembly of a Polymer with an Appended Donor-Acceptor Dyad and Prominent Piezoelectricity. | This study reveals biomimetic folding and hierarchical self-assembly of a segmented polyurethane by employing multiple noncovalent interactions, operating in orthogonal manner. The polymer contains a pendant donor (D)-acceptor (A) dyad in each repeating unit and urethane groups in its backbone. Intrachain D-A charge-tr... |
41581192 | Determination of Nucleation Process and Spherical Micelle Growth by Time-Resolved SAXS During PISA: Evidence from Liquid Crystalline Spherical Nanoparticles. | Polymerization-induced self-assembly (PISA) has emerged as a versatile and scalable approach for producing block copolymer nanoparticles with precisely controlled, narrow size distributions. However, the mechanism by which PISA via reversible addition-fragmentation chain transfer (RAFT) polymerization achieves narrow p... |
41581175 | Enhanced Polysulfide Redox Reaction of Co/Fe Dual-Atom Catalysts Embedded in Metal-Organic Framework-Derived Microporous Carbon Electrode for Lithium-Sulfur Cells. | Lithium-sulfur (Li-S) batteries have attracted significant interest owing to their high theoretical energy densities and cost-effectiveness. However, their practical application is hindered by sluggish lithium polysulfide (LiPS) redox kinetics and the shuttle effect, which result in rapid capacity decay and poor rate p... |
41581163 | Enzyme-Activated Programmable Theranostic Platform for Spatiotemporal Imaging of Intracellular MicroRNA and On-Demand Manipulation-Mediated Therapy. | Imaging the aberrant expression of a single microRNA (miRNA) in living cells is often inadequate for accurately evaluating pathological states or implementing responsive therapies. It is a critical need for advanced molecular tools capable of spatiotemporally sensing miRNA and other biomarkers, accompanying the on-dema... |
41581160 | Efficient, Reversible Lead Adsorption in a Thiol-Decorated Zirconium-Metal-Organic Framework. | Metal-organic frameworks (MOFs) featuring high densities of selective metal binding sites represent promising materials for the extraction of toxic metal ions from liquids. This study presents a Zr-MOF containing accessible thiol functionalities that demonstrates exceptional adsorption capacity and recyclability for th... |
41581157 | Multifunctional Superwetting Sea-Urchin-Mimetic Nanosheet-Based Interface for Remote Oil-Water Separation. | Rapid and large-scale oil spill remediation remains an urgent environmental and technological challenge. Here, we present a transformative, multifunctional bio-inspired platform for on-site, remotely actuated, and contactless oil-water separation that integrates an advanced membrane with electronics deployment. Here, w... |
41580984 | Protein Language Model-Guided Engineering of a 2,3-Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α-Hydroxy Ketones. | (2R,3R)-butanediol dehydrogenases (BDHs) are promising catalysts for the production of α-hydroxy ketones, which are highly valuable compounds in the synthesis of fine chemicals and pharmaceuticals. However, (2R,3R)-BDHs display limited stereoselectivity, thus restricting wider applications. In this study, we engineered... |
41884281 | Emerging Salivary Exosome Nanodiagnostics for Early Oral Squamous Cell Carcinoma: Platforms, Biomarkers, and Future Perspectives. | Early oral squamous cell carcinoma (OSCC) is frequently missed because conventional imaging and biopsy are poorly suited to detect subtle, preclinical molecular changes. Emerging salivary exosome nanodiagnostics aims to convert an anatomically proximal, information-rich nanoscale biospecimen into quantitative and repea... |
41878123 | Nanoformulated Phytochemicals Against Pancreatic Cancer: Emerging Advances in Therapeutic Strategies. | <h4>Background</h4>Pancreatic cancer (PC) is an aggressive malignancy that has become one of the leading causes of cancer-related death worldwide. Remarkably, phytochemical-based nanoformulations have demonstrated great potential in combating cancer progression. Therefore, the objective of this scoping review is to ana... |
41810474 | Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis. | Connective tissue growth factor (CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study presents a groundbreaking supramolecular cryo-shock bone marrow mononuclear cell system for targeted drug delivery in IPF. We incorporated antisense oligonucleotides (ASO) to inhibit CTGF and si... |
41753560 | Experimental Evolution of Pathogenic <i>Candida</i> spp.: Insights into Adaptive Processes and Evolutionary Dynamics. | Among <i>Candida</i> species, several are major opportunistic fungal pathogens capable of causing a wide spectrum of infections, ranging from superficial mucosal conditions to severe systemic diseases. Their success as human pathogens is largely due to their ability to rapidly adapt to diverse host environments and dev... |
41746036 | Vaccination with Lipid Nanoparticle-Delivered VP2-DNA Elicits Immune Protection in Chickens Against Novel Variant Infectious Bursal Disease Virus (nVarIBDV). | <h4>Background/objective</h4>Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease in chickens caused by infectious bursal disease virus (IBDV). In recent years, a novel variant IBDV (nVarIBDV) has emerged and spread widely, inducing severe immunosuppression and posing a substantia... |
41744972 | β-Hairpin-Based Peptide Hydrogels: The Case of MAX1. | This review explores the advancements and applications of β-hairpin peptide hydrogels, starting from the paradigmatic case of MAX1 and its highly versatile analogue MAX8. MAX1 (H-VKVKVKVKV<sup>D</sup>PPTKVKVKVKV-NH<sub>2</sub>) has been identified as the first synthetic β-hairpin peptide for the preparation of stimuli-... |
41744689 | Progress in Electrochemical and Fluorescence Sensors for Propyl Gallate Monitoring in Food Samples. | Recent years have witnessed significant growth in the development of propyl gallate (PG) sensors. PG can be monitored by various approaches, such as electrochemical and fluorescence methods. The electrochemical approaches have several advantages, such as low cost, a benign fabrication process, and high sensitivity and ... |
41737063 | Analysis of Galectin-3 in Differentiating Non-malignant and Malignant Nodular Thyroid Lesions. | Introduction Accurate differentiation of benign and malignant thyroid nodules is critical for appropriate management. Fine-needle aspiration cytology (FNAC), although valuable, has limitations, especially in follicular-patterned neoplasms. Galectin-3, a beta-galactoside-binding lectin involved in cell proliferation and... |
41732743 | Bioactive Metabolites from <i>Lactobacillus acidophilus</i>-Fermented Products Mitigate Carbon Tetrachloride-Induced Liver Injury: Biochemical and In Silico Insights. | <h4>Background</h4>Fermented products derived from <i>Lactobacillus</i> have demonstrated therapeutic potential in the management of metabolic disorders, particularly liver diseases.<h4>Objectives</h4>This study aimed to evaluate the hepatoprotective effects of <i>Lactobacillus</i>-fermented products in a carbon tetrac... |
41717018 | A nucleation distance sets the cell size-dependent P-body assembly in yeast. | Cells rely on diverse intracellular structures, including phase-separated granules, to regulate biological processes. Processing bodies (P-bodies) are membraneless cytoplasmic condensates that mediate mRNA degradation and storage. Although their molecular composition is well studied, how their spatial organization rela... |
41683616 | Sequence-Encoded Aggregation of AA10 LPMO Domains as a Basis for Inclusion Body Design. | Inclusion bodies (IBs) in <i>Escherichia coli</i> are increasingly recognised as nanostructured materials with tunable morphology and functional potential. The N-terminal auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenase (LPMO) domain from <i>Caldibacillus cellulovorans</i> (Ccel<sub>p40</sub>) con... |
41683385 | Revealing the Bioactive Potential of Romanian Wild Hop Cones: An Integrative Chemical, Antimicrobial, and Antibiofilm Activity and In Silico Docking Analysis. | Hop (<i>Humulus lupulus</i> L.) is recognized as a valuable source of bioactive compounds; however, the phytochemical composition and biological potential of wild Romanian hops remain insufficiently characterized. In this study, the bioactive profile of wild hop cones was evaluated using an integrated phytochemical, bi... |
41683018 | Recent Progress in Probiotic Encapsulation: Techniques, Characterization and Food Industry Prospects. | Although probiotics are widely used in the food industry due to their health-promoting effects, their application is often limited by low stability and poor viability under processing, storage, and gastrointestinal conditions. Encapsulation has emerged as a promising strategy to address these issues, offering enhanced ... |
41682024 | Recent Advances in Fluorinated Colloidal Nanosystems for Biological Detection and Surface Coating. | Fluorinated colloidal nanosystems have attracted significant attention for their advantageous properties and potential applications in the biomedical field, especially in <sup>19</sup>F magnetic resonance imaging. These nanosystems are known for their high specificity, excellent biocompatibility, and ease of functional... |
41681534 | Phage Therapy in Plant Disease Management: 110 Years of History, Current Challenges, and Future Trends. | Bacteriophages, or phages, are viruses that specifically infect and lyse bacterial cells. Since their discovery 110 years ago, they have held a unique place in microbiology, medicine, and agriculture as both scientific tools and potential therapeutic agents. The concept of employing phages to combat bacterial infection... |
41681529 | Nanoparticle Applications in Plant Biotechnology: A Comprehensive Review. | Nanotechnology is becoming a key tool in plant biotechnology, enabling nanoparticles (NPs) to deliver biomolecules with high precision and to enhance plant and tissue resilience under stress. However, the literature remains fragmented across genetic delivery, in vitro regeneration, stress mitigation, and germplasm cryo... |
41663218 | A peptide-functionalized quantum Dots/MOF nanosheets fluorescence biosensor for glutathione sensing and cellular imaging. | <h4>Background</h4>Glutathione (GSH), the most abundant cellular non-protein thiol and a central antioxidant, plays essential roles in regulating redox homeostasis, signal transduction, and detoxification processes. Altered GSH levels are closely associated with various pathological conditions, including neurodegenerat... |
41660123 | Nanozyme for precision treatment of hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) remains a formidable challenge due to profound heterogeneity, recurrence, and pervasive therapeutic resistance, creating a significant unmet clinical need. Engineered nanozymes, nanomaterials with intrinsic catalytic activities, have emerged as a transformative paradigm. Unlike passive na... |
41660121 | Photocrosslinkable lung dECM hydrogels promote stiffness-dependent lung cancer growth and chemoresistance. | Decellularized extracellular matrices (dECMs) are promising biomaterials for generating tissue-specific <i>in vitro</i> models due to their organotypic extracellular matrix (ECM) protein profiles compared to natural and synthetic alternatives. However, most dECM-based hydrogels rely on collagen fibrillogenesis, resulti... |
41646625 | Alkaline-pH-shifted mung bean protein isolate for spray-dried probiotic encapsulation: Insights into molecular cell wall interactions and oxidative protection. | Probiotics suffer low viability from heat and oxidative stress during spray drying. This study evaluated alkaline-pH-shifted mung bean protein isolate (pHMBPI) as an encapsulant for <i>Limosilactobacillus reuteri</i> KUB-AC5, compared with mung bean protein isolate (MBPI) and whey protein isolate (WPI). pHMBPI showed t... |
41643508 | Self-assembly nanostructured polysulfoniums as antimicrobial potentiator targeted bacterial membrane reversing antimicrobial resistance. | Antimicrobial resistance (AMR) poses a critical public health threat, primarily driven by the misuse and overuse of antimicrobials in both veterinary and public healthcare systems. In the face of accelerating AMR and a dwindling antibiotic pipeline, the strategic deployment of adjuvant therapies presents a promising ap... |
41605083 | A novel ratiometric fluorescent sensing strategy of arginine based on lanthanide-based metal-organic framework. | Arginine (Arg) has been recognized as a crucial biomarker for cystinuria, with its concentration levels markedly influencing human health. In this study, Eu-TATB were synthesized via a solvothermal method using 4,4',4″-s-triazine-2,4,6-triyl-tribenzoic acid (H₃TATB) as the organic ligand and Eu ions. Eu-TATB, benefitin... |
41605080 | Machine learning-assisted ratiometric fluorescent sensing platform based on antenna effect in Tb-doped metal-organic framework for visual quantification of enoxacin. | In this work, a ratiometric fluorescent sensing platform based on the antenna effect in Tb-doped metal-organic framework (Tb-MOF) was constructed for sensitive and visual detection of enoxacin (Eno). The coordination of Tb<sup>3+</sup> with the β-diketone structure of the Eno molecule activates yellowish-green fluoresc... |
41631272 | CircRNA-regulated programmed cell death networks in cardiomyocytes: Molecular crosstalk and therapeutic translation. | Cardiovascular diseases (CVDs) represent the predominant global health burden, where dysregulated programmed cell death (PCD) mechanisms critically drive myocardial injury pathogenesis. Circular RNAs (circRNAs), characterized by covalently closed structures conferring high stability, function as pivotal regulators coor... |
41630825 | Targeting mechanosensitive EphA2 phase separation to alleviate arterial stiffening. | Arterial stiffening, a major cardiovascular risk factor, is driven by aberrant mechanotransduction in vascular smooth muscle cells (VSMCs), yet the critical mechanoreceptors and underlying mechanisms remain elusive. Here, we identified Ephrin receptor A2 (EphA2) as a significantly upregulated mechanosensitive receptor ... |
41625493 | An AI-assisted designed supramolecularly engineered nanoplatform reverses pigmentation by triggering an ineffective compensatory melanin production program. | The clinical applications of natural compounds are limited by their inherent physicochemical properties. This study reports a hierarchical supramolecular engineering strategy for constructing a dual-assembly nanosystem for the treatment of skin hyperpigmentation. Using an AI-assisted computational screening model, tran... |
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