id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
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41613251 | Revival of Layered Ferroelectrics in Thin Films. | Layered perovskites form a versatile class of ferroelectrics in which structural anisotropy gives rise to periodic electrostatics and, consequently, unconventional ferroelectric properties. These materials fall into four main families: Aurivillius, Carpy-Galy, Ruddlesden-Popper, and Dion-Jacobson phases, each forming n... |
41610745 | Single-atom co anchored UiO-66 to boost electrochemiluminescence of MoS<sub>2</sub> for bioanalysis. | Single-atom catalysts (SACs) hold significant promise for improving the electrochemiluminescence (ECL) efficiency. However, the preparation of SACs reported in the ECL field usually relies on carbon-nitrogen-based materials as substrates and requires high-temperature pyrolysis (>800 °C), suffering from the limitation i... |
41610660 | Application of microfluidic chip coupled with carbon dots-MOF-enriched chromogenic membrane in the detection of various perfluorinated compounds. | Perfluorinated compounds (PFCs), due to their persistence, toxicity, and bioaccumulation, pose significant environmental and public health concerns. However, their low concentrations and the complexity of environmental matrices present major analytical challenges. In this study, we developed a carbon quantum dot-based ... |
41587572 | Nanomaterial-based electrochemical sensors for phenolic antioxidants in foods and beverages: From design to device translation. | Nanomaterial-enabled electrochemical sensors are nearing the performance and practicality needed for routine, on-site monitoring of phenolic compounds in foods and beverages. Advances in nanomaterial dimensionality and hybrid architectures, from atomically doped nanoparticles and zero-dimensional clusters to two- and t... |
41581307 | Research progress of single molecule sensors based on DNA platform. | Deoxyribonucleic acid (DNA) is the genetic blueprint of living organisms and represents one of the most fundamental molecules across species. Recent research and development in the field of materials science indicates that DNA is not only highly programmable, but also a nanomaterial capable of precise self-assembly. In... |
41580924 | Molecular-Scale Tuning of Low-Molecular-Weight Gelators Controls Supramolecular Assembly and Directs Human Mesenchymal Stem Cell Growth. | We report the synthesis and characterization of a simple alcohol-functionalized low-molecular-weight gelator (LMWG) based on a 1,3:2,4-dibenzylidenesorbitol scaffold (DBS-CH<sub>2</sub>OH) and explore its self-assembly in comparison to acylhydrazide-functionalized DBS-CONHNH<sub>2</sub>. DBS-CH<sub>2</sub>OH forms a st... |
41580922 | Ferritin-Doped Nanoparticles Triggered Tumor-Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation. | Combining the lysosomal targeting ability of human ferritin heavy chain (HFn) and the strong oxidizing property of gallic acid-iron complex (GA-Fe), a hybrid nanoparticle HFn/GA-Fe was synthesized by a cross-linking reaction. We discovered that HFn/GA-Fe would specifically darken the color of tumors after intravenous i... |
41580909 | Temperature-Responsive Near-Infrared Emission Enabled by Reversible π-Umpolung with an Alkenyl-Strapped Diarylboryl Unit. | Coordination of a Lewis base to a tricoordinate boryl group generates a tetracoordinate species, thereby inverting the electronic character of the boryl substituents from electron-accepting to electron-donating. Utilizing this π-umpolung strategy, we report temperature-responsive fluorophores that emit in the near-infr... |
41580905 | Organic Transistor-Based Neuromorphic Electronics and Their Recent Applications. | Neuromorphic technologies offer a promising pathway to address the escalating energy demands of artificial intelligence. At the system level, neuromorphic computing seeks to overcome the von Neumann bottleneck by integrating memory and processing, while neuromorphic sensing minimizes redundant data transfer by processi... |
41580903 | Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation. | Catalysis of bond-forming reactions is key to the development of life-like chemical systems as it allows to build up new material, increasing molecular complexity and diversity. Integrating catalysis with other characteristic properties of life, like self-replication, represents an important advance in the transition f... |
41580793 | Microneedle-delivered ROS-adaptive asiatic acid nanoparticles promote scarless repair via remodeling the pathological microenvironment. | Hypertrophic scar (HS) is a pathologic fibrotic disease caused by aberrant wound healing following severe skin injury. Despite advances in clinical treatments, the therapeutic outcomes remain suboptimal, mainly due to inadequate penetration through the thickened stratum corneum barrier and insufficient site-specific dr... |
41580768 | Single-cell transcriptomics uncover RNF130-mediated TNF-α pathway activation and worenine synergy with paclitaxel in breast cancer. | <h4>Background</h4>Triple-negative breast cancer (TNBC) is distinguished by high invasiveness and a tendency for recurrence. Recent studies have suggested that E3 ubiquitin ligases play a crucial role in the initiation and progression of various tumors. However, there is still an absence of systematic understanding reg... |
41580747 | Recent advances in nanomaterial-based precision medicine for orthotopic tumor therapy. | The escalating global burden of cancer, marked by high incidence and mortality, necessitates more effective therapeutic strategies. A major bottleneck in clinical translation is the long-standing reliance on subcutaneous tumor models, which fail to recapitulate the complex physiological and pathological features of hum... |
41580683 | Renal-tubular-mitochondrial sequentially targeted nanoagent breaks the vicious cycle of oxidative stress and mtDNA-driven inflammation in acute kidney injury therapy. | Acute kidney injury (AKI) is a life-threatening disorder that is responsible for 1.7 million deaths each year. Current treatment strategies, such as renal replacement therapy and supportive care, remain ineffective in reversing tubular damage in 20-50% of patients, largely due to their inability to promptly restore ren... |
41580589 | Consensus-based computational mapping of NS1 antigenic determinants in dengue and Zika viruses to improve diagnostic specificity. | <h4>Background</h4>Cross-reactivity between samples from phylogenetically related organisms remains a significant challenge in antigen detection by lateral flow assays. Recent advancements in bioinformatics tools have significantly enhanced our understanding of the complex interactions between antigenic proteins and an... |
41580501 | An integrated workflow for the structure elucidation of nanocrystalline powders. | Structural characterization of powder materials, including those synthesized by mechanochemical methods, remains challenging due to the lack of single crystals suitable for X-ray diffraction. Microcrystal-Electron Diffraction (MicroED) enables structure determination from sub-micrometer crystallites but faces limitatio... |
41580489 | Graphene oxide functionalized metalloporphyrins as advanced antimicrobial nanomaterials with integrated synthesis, characterization and molecular docking evaluations. | This study reports the synthesis and doping of reduced graphene oxide (rGO) with metalated porphyrins-nickel [Ni-t(OH)<sub>4</sub>-Por] (M1-Por), zinc [Zn-t(OH)<sub>4</sub>-Por] (M2-Por), and manganese [Mn-t(OH)<sub>4</sub>-Por] (M3-Por) to develop reduced graphene oxide-porphyrin nanocomposites (rGO-M1-Por, rGO-M2-Por... |
41580488 | Integrated safety and microbiota profiling of fulvic acid formulations across in vitro and in vivo models. | Fulvic acid, a naturally occurring organic compound derived from humic substances, has recently emerged as a multifunctional bioactive agent with potential biological relevance. Here, we evaluated the in vitro bioactivity of various fulvic acid-containing formulations, focusing on cytocompatibility, genotoxicity, anti-... |
41580442 | Printing technologies for monitoring crop health. | Agricultural production requires low-cost sensors capable of delivering reliable, high-resolution data across large areas. Rising food demand, limited arable land, and severe soil degradation have accelerated the adoption of precision agriculture, which relies on real-time monitoring of soil, plant, and environmental c... |
41580424 | A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity. | Malaria parasite transmission remains a barrier to elimination since asymptomatic individuals sustain the infectious reservoir. Transmission-blocking vaccine (TBV) candidates targeting Plasmodium falciparum (Pf) gametocyte surface proteins Pfs230 and Pfs48/45 have shown promise in clinical trials. Several vaccine candi... |
41580413 | Molecular recognition of thyroglobulin by sortilin. | Sortilin is a ubiquitous membrane receptor mediating trafficking of protein cargoes. In the thyroid, sortilin binds thyroglobulin (TG) during its endocytosis, a key process in thyroid homeostasis. Although sortilin has been proposed to recognise highly iodinated TG, the molecular details of this interaction remain unkn... |
41580408 | Bernoulli's principle-mediated Cl<sub>2</sub> electrosynthesis. | Existing technologies for chlorine (Cl<sub>2</sub>) synthesis are generally suffered from low productivity or high production cost. Guided by Bernoulli's principle, here we report an efficient yet cost-effective electrochemical system for Cl<sub>2</sub> electrosynthesis, which is composed of anodic chlorine evolution r... |
41579404 | Guest-Induced Large and Tunable Negative Thermal Expansion in Soft Microporous Carbon. | Materials that exhibit negative thermal expansion (NTE) are of fundamental interest due to their rarity and counterintuitive behavior. While research in this area has been directed toward the discovery of materials that display NTE and explaining its origin, there has been less attention to describing the complexities ... |
41579381 | A Transferable Force Field for Simulating Adsorption in Metal-Organic Frameworks with Open Metal Sites Based on the 12-6-4 Lennard-Jones Potential. | Metal-organic frameworks (MOFs) that contain coordinatively unsaturated open metal sites (OMSs) provide strong host-guest interactions, making them promising sorbents for low-concentration gas adsorption applications such as direct air capture and atmospheric water harvesting. However, accurately modeling host-guest in... |
41579332 | Self-assembling dendrimer nanoparticles in cancer therapy. | Malignant cancer remains the leading cause of mortality globally, and advancements in nanotechnology-driven nanomedicine are expected to yield promising alternative therapeutic strategies. Dendrimers, as synthetic polymers, possess a broad potential for biomedical applications. In this respect, self-assembling dendrime... |
41579221 | Anti-angiogenesis effect of Baiying Juhua Decoction on the non-small cell lung cancer: integrating pharmacology, multi-machine learning and experimental investigation. | Baiying Juhua Decoction (BYJHD) is a well-established traditional Chinese herbal formula primarily composed of Solanum lyratum and chrysanthemum, which necessitates a thorough investigation to clarify its mechanisms in combating non-small cell lung cancer (NSCLC). This study employed a combination of network pharmacolo... |
41579082 | Role of Side-Chain Length and Counterion Mediation on Dimerization of Rigid Sphere-Rod Amphiphiles: A Molecular Dynamics Investigation. | Rigid sphere-rod amphiphiles (RSRAs) comprising a Keggin polyoxometalate (POM) headgroup and an oligofluorene rod with different side chain lengths (C2, C6, C10, C16, are the number of carbon atoms per side chain) were probed by all-atom molecular dynamics in THF/water mixtures (15 and 33 vol % THF) with tetrabutylammo... |
41579078 | Planarity-Driven Structure-Morphology Correlations in a Co(II) Benzoylacetonate: Comparative Insights across the [M(bzac)<sub>2</sub>] Family. | Advancing structure-packing-morphology correlations in β-diketonate complexes provides a rigorous framework for how local coordination geometry propagates into supramolecular organization and ultimately governs macroscopic form. Within this context, we report the synthesis, single-crystal and powder X-ray diffraction a... |
41579072 | Controlling the Kinetic and Electrochemical Properties of Eu<sup>II</sup>-Containing Complexes Using Peripheral Charges. | The development of Eu-based contrast agents for magnetic resonance imaging requires careful balance between electrochemical potential and inertness with respect to metal dissociation. Using coordination chemistry, this study aimed to understand how the distance between peripheral anionic groups and Eu<sup>II</sup> in m... |
41578972 | NanoBondy Reaction through NeissLock Anhydride Allows Covalent Immune Cell Decoration. | Cell-surface conjugation has enormous therapeutic and research potential. Existing technologies for cell-surface modification are usually reversible, nonspecific, or rely on genetic editing of target cells. Here, we present the NanoBondy, a nanobody modified for covalent ligation to an unmodified protein target at the ... |
41578928 | Dual-functional nanoparticle formulations for simultaneous intraocular pressure reduction and neuroprotection in glaucoma: a review. | Glaucoma is a leading cause of irreversible blindness, driven by elevated intraocular pressure (IOP), progressive retinal ganglion cell (RGC) loss, and optic nerve degeneration. Current therapies rely on lowering IOP, which slows but does not halt disease progression. Dual-functional nanoparticle (NP) formulations repr... |
41578794 | Key cuticular proteins mediating molting and environmental stress response in Panonychus citri. | <h4>Background</h4>Cuticular proteins (CPs), key structural components of the insect cuticle, play essential roles in growth, metamorphosis, and defense against environmental stresses. Panonychus citri, a globally significant pest mite, severely impacts citrus orchard productivity. Targeting critical CP genes offers a ... |
41577823 | Obesity impairs spermatogenesis via Leydig cell ferroptosis induced by liver-derived exosomal miR-122-5p. | Obesity increases the risk of male infertility, primarily attributable to reduced testosterone levels. Exosomes, which facilitate intercellular communication during reproduction, may influence this process. However, the relation between exosomal cargo changes and high-fat diet (HFD)-induced testosterone decrease remain... |
41577813 | Identification and characterization of MARCO-expressing tumor-associated macrophages in pancreatic ductal adenocarcinoma with pan-cancer relevance. | Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. The role of macrophage receptor with collagenous structure (MARCO), a scavenger receptor class-A protein expressed on macrophage surface, in PDAC progression remains unclear. Here, we identified a subset of MARCO-expressing macrophages w... |
41577735 | A density functional theory study of cyclophosphamide and purinethol adsorption on a covalent triazine framework (CTF-2) for drug delivery applications. | The conventional delivery systems are ineffective in therapeutics because of poor adsorption at target site. Conversely, 2D sheet based materials are the advanced drug delivery systems that provide decent adsorption and good attraction with drug molecules and can be used as a carrier of effective drug delivery. In this... |
41918436 | Diazonium acid-dyes elimination via complexation with sulfonated calix[4]arene soluble in aqueous medium; on an experimental and theoretical study. | This research highlights the effectiveness in employing a sulfonated para-tert-butylcalix[4]arene derivative (SCX4) as an effective molecular host for adsorption of acidic azo dyes in aqueous environment. Due to its inherent stability and rigidity, this chemical may be suitable as a host for host-guest interactions. Th... |
41909750 | Ferroptosis-based nano-assembly enhanced breast cancer therapy by inhibiting intratumor bacteria. | Intratumoral bacteria, especially Gram-positive bacteria (G<sup>+</sup>), have a unique bacterial niche in breast cancer that promoted tumor progression. However, the effects of G<sup>+</sup> have so far been overlooked, serving an "invisible driver" of breast cancer. Moreover, due to the altered biological structure o... |
41909144 | Determination of Nucleotide-Nucleotide and Nucleotide-Amino Acid Binding Interactions from All-Atom Potential-of-Mean-Force Calculations. | Biomolecular condensates emerge from multivalent interactions between proteins and nucleic acids and are frequently modeled by using coarse-grained molecular dynamics simulations. The parametrization of these models critically depends on atomistic data describing the underlying molecular interactions. In this work, we ... |
41869407 | Thermoradiotherapy-Driven Enhancement of Cuproptosis by Copper-Nitroimidazole Based Nanoparticles. | <h4>Introduction</h4>Cuproptosis, a novel form of cell death tied to copper homeostasis and protein lipoylation, holds significant promise for breast cancer treatment. However, its efficacy is severely hindered by the tumor microenvironment (TME) heterogeneity, such as hypoxia and elevated glutathione (GSH) levels.<h4>... |
41869396 | Nanotechnology-Driven Cancer Therapies for Precision Oncology: Advances and Clinical Outlook. | Cancer continues to pose a global health challenge, with conventional therapies often limited by non-specific toxicity, drug resistance, and an inadequate therapeutic index. Nanotechnology offers transformative opportunities by enabling targeted drug delivery, improved pharmacokinetics, and integrated diagnostic-therap... |
41867317 | Revolutionizing Food Safety: A Systematic Review of Nanotechnology-Based Aflatoxin Detection (2010-2023). | Food safety remains a critical global challenge, particularly due to contamination by aflatoxins (AFs), highly toxic secondary metabolites produced primarily by <i>Aspergillus flavus</i> and <i>A. parasiticus</i>. This significant group of mycotoxins frequently contaminate staple food commodities, posing serious risks ... |
41755874 | Sustainable and Scalable Flow Photochemical Conversions Using a Labile Ligand-Assembled Iron Complex. | Photocatalysis is an emerging toolbox for challenging redox reactions in a sustainable manner. Designed heterogeneous and homogeneous photocatalysts show excellent catalytic performances for various reactions at a lab scale, yet photocatalytic chemical conversions at a practical level are hindered by the efficiency, co... |
41744970 | Recent Advances in Smart Stimulus-Responsive Hydrogels for Precision Drug Delivery in Tumours. | Cancer remains one of the most prominent global health concerns, posing a substantial threat to public health. Millions of people die from cancer each year, and many cancer types remain incurable at present. Conventional cancer treatments, including surgery, chemotherapy, radiotherapy, and immunotherapy, often fail to ... |
41740201 | UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. | NMDA receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission in the central nervous system where they play critical roles in normal and pathological brain functions and neurodevelopment. Glutamate/glycine-activated GluN2-containing NMDA receptors (GluN1/GluN2) have been extensively studie... |
41710748 | Peptide-Functionalized Liposomal Nanocarriers for Targeted Therapy of Liver Fibrosis and Hepatocellular Carcinoma: Design, Mechanisms, and Clinical Prospects. | Liver fibrosis and hepatocellular carcinoma (HCC) remain major global health burdens, in part due to limited drug specificity, off-target toxicity, and the complex hepatic microenvironment. Peptide-functionalized liposomal nanocarriers have emerged as a promising approach to enhance cell-selective drug delivery to acti... |
41696695 | On-surface synthesis of nonbenzenoid nanographenes through skeletal rearrangement reactions on Au(111). | Skeletal rearrangement reaction is a class of important chemical reactions to synthesize various constitutional isomers from a given precursor molecule. This approach allows the synthesis of diverse nanographenes incorporating five- and seven-membered rings, thereby tuning their chemical and physical properties. Here, ... |
41696301 | <i>In Vitro</i> and <i>In Silico</i> Evaluation of the Trypanocidal Activity of a Subfraction Isolated from <i>Mutisia campanulata</i>. | In the present study, a subfraction rich in aliphatic hydrocarbons and pentacyclic triterpenes was isolated after chromatographic steps from <i>Mutisia campanulata</i> Less and its trypanocidal activity were evaluated using <i>in vitro</i> and <i>in silico</i> approaches. The chemical structures of the compounds presen... |
41696286 | Ligand-Exchange-Induced Growth of NiCo-LDH on Halloysite for Enhanced Flame Retardancy of Unsaturated Polyester Resin. | Unsaturated polyester resin (UPR) is a long-chain, hydrocarbon-rich thermoset that is intrinsically highly flammable, which severely limits its engineering applications. Herein, NiCo-layered double hydroxide (NiCo-LDH) nanosheets were covalently grafted onto halloysite nanotubes (HNTs) via an in situ substitution route... |
41696263 | Neodymium and Yttrium Adsorption on Citrate-Modified Cellulose: Experimental and Computational Insights. | Neodymium (Nd) and yttrium (Y), two rare earth elements, play a crucial role in a wide range of technologies, and their separation is a challenging process. Adsorption-based approaches offer a sustainable and cost-efficient substitute for the most widely used solvent extraction procedure. Here, we assess the potential ... |
41696253 | Development of a Molecularly Imprinted Pencil Graphite Electrode for the Voltammetric Detection of Hg<sup>2+</sup> Ions. | The ability to detect trace amounts of mercury has become critical due to its possible severe toxic effects on both humans and the environment when exposed to unsafe amounts. This study focuses on developing a novel mercury detection technique using differential pulse anodic stripping voltammetry (DPASV) with a pencil ... |
41696245 | Preparation and Characterization of Carvacrol-Loaded PLA Nanofibers by the Solution Blow-Spinning Method for the Long Shelf-Life of Chicken Breast Meat. | Using natural active packaging materials in food preservation is a healthy and safe method. Chicken meat is one of the foods in which microorganisms grow rapidly and so has a short shelf life. Extending the shelf life of food is also important for the economy. Packaging with biodegradable antimicrobial materials can re... |
41696230 | Exploring Approaches for Accelerated Mass Spectrometric Detection of Fluorochemicals from Aqueous Solutions Using Indirect, Adsorbent-Facilitated Desorption Ionization. | There is a growing need for rapid, low-cost analytical tools to screen water supplies for persistent contaminants. Due to their ubiquitous presence in the environment and their detrimental effects on human health, there is a public interest in widespread testing for perfluoroalkyl substances (PFAS). However, the most c... |
41696208 | 3D rGO and rGO/TiO<sub>2</sub>-Modified Melamine Sponges: Sorbents for Oil and Emerging Organic Pollutant Removal. | Environmental disasters resulting from the exploitation of natural resources, such as oil spills, have severe and lasting impacts on ecosystems. In this work, melamine sponges were modified with reduced graphene oxide (rGO) and titanium dioxide nanosheets (TiO<sub>2</sub>) to develop multifunctional materials for envir... |
41683580 | Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer-A Comprehensive Review of Literature. | Pancreatic cancer (PC) remains a highly lethal malignancy with limited treatment options and poor survival. Targeting DNA damage response (DDR) pathways has emerged as a promising therapeutic strategy, particularly the ATR-CHK1 and ATM-CHK2 axes. Preclinical studies demonstrate that ATR inhibition disrupts replication ... |
41683564 | From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis. | Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases that, despite the availability of symptomatic and modestly beneficial treatments, still lack therapies capable of halting disease progression. A histopathological hallmark of both diseases is the cytoplasmic... |
41683381 | Tuning the Crystal Structure of Amphiphilic 3,4,5-Tris(alkyloxy)benzenesulfonates with Bulky Tetrabutylammonium Cations by Variation in the Aliphatic Chain. | 3,4,5-Tris(alkyloxy)benzenesulfonates constitute a class of wedge-shaped dendrons exhibiting liquid crystalline properties, characterized by a diverse and intricate phase behavior that is predominantly governed by the length of the terminal aliphatic chains and the size and nature of the dendrons' focal group, which co... |
41683374 | Cuproptosis: Biomarkers, Mechanisms and Treatments in Diseases. | The homeostasis balance of copper, as an essential trace element for life activities, is crucial for maintaining the normal function of cells. Cuproptosis, discovered in recent years, is a novel type of programmed cell death triggered by the accumulation of excessive copper ions in mitochondria. The core mechanism lies... |
41683204 | Kaempferol Inhibits MMP-1-Mediated Migration and Invasion in Gemcitabine-Resistant Pancreatic Cancer Cells. | <b>Background:</b> Pancreatic cancer (PaCa) has an extremely poor prognosis. This malignancy rapidly acquires resistance to gemcitabine (GEM), a key chemotherapeutic agent, yet the mechanisms underlying this resistance remain incompletely understood. We previously established GEM-resistant (GEM-R) PaCa cell lines and f... |
41682018 | Research Advances in Conjugated Polymer-Based Optical Sensor Arrays for Early Diagnosis of Clinical Diseases. | Early and accurate diagnosis is critical for disease surveillance, therapeutic guidance, and relapse monitoring. Sensor arrays have emerged as a multi-analyte detection tool via non-specific interactions to generate unique fingerprint patterns with high levels of selectivity and discrimination. Conjugated polymers (CPs... |
41681697 | The Landscape of Ferroptosis-Related Gene Signatures as Molecular Stratification in Triple-Negative Breast Cancer. | <b>Background:</b> Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, characterized by high genomic instability, metabolic stress, and limited therapeutic options. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a promising vulnerability in TNBC, yet i... |
41681347 | Construction of Bovine CypA Gene Expression Vector and Validation of Its Expression in CHO-K1 Cells. | Bovine mastitis remains a globally prevalent disease, with the limitations of antibiotic-based treatments-such as the rise in antimicrobial resistance and the presence of drug residues-highlighting the urgent need for alternative therapeutic approaches. Inflammation is intricately linked to various cytokines and immuno... |
41681149 | Unveiling the Bio-Interface via Spectroscopic and Computational Studies of (Propyl-3-ol/butyl-4-ol)triphenyltin(IV) Compound Binding to Human Serum Transferrin. | Two structurally tunable (propyl-3-ol)triphenyltin(IV) (<b>Ph<sub>3</sub>SnL<sub>1</sub></b>) and (butyl-4-ol)triphenyltin(IV) (<b>Ph<sub>3</sub>SnL<sub>2</sub></b>) compounds were investigated at the human serum transferrin (<b>Tf</b>) molecular interface to resolve how ligand architecture and protein metallation modu... |
41681136 | Aperiodicity in Low Dimensions. | This review provides a comparative analysis of the structure and physical properties of low-dimensional aperiodic crystalline solids, aiming to elucidate the origin and nature of aperiodicity in reduced-dimensional lattices. The breakdown of periodicity in low-dimensional systems arises from several mechanisms, includi... |
41677682 | Fermented Red Ginseng Restores Age-Associated Insulin Homeostasis and Gut Microbiome Balance in Mice. | Biological aging disrupts liver-gut intercommunication, resulting in the development of insulin resistance and type 2 diabetes, coupled with the imbalance of gut microbiome composition known as gut dysbiosis. Fermented red ginseng (FRG) is a renowned functional food substance showing its notable anti-inflammatory and a... |
41677579 | Gene and Cell Therapy in Regenerative Medicine. | Gene and cell therapies have become core components of regenerative medicine, moving from proof-of-concept studies toward clinically actionable strategies for repairing or replacing damaged tissues [...]. |
41677505 | Innovative Trinuclear Copper(I)-Based Metal-Organic Framework: Synthesis, Characterization, and Application in Laser-Induced Graphene Supercapacitors. | Optimizing efficient electrode materials that combine high energy density, rapid charge transport, and excellent cycling stability remains a challenge for advanced supercapacitors. Here, we report the synthesis of an innovative copper(I)-based metal-organic framework (MOF), Cu<sub>3</sub>(NDI)<sub>3</sub>, prepared via... |
41660614 | Characteristics of T-lymphocyte subsets in patients with severe fever with thrombocytopenia syndrome complicated with invasive pulmonary aspergillosis: a retrospective study. | <h4>Objectives</h4>Immunosuppressed patients often acquire invasive pulmonary aspergillosis (IPA). In recent years, the incidence of patients with severe fever with thrombocytopenia syndrome (SFTS) complicated with IPA has increased. This study aimed to investigate the characteristics of the counts of T-lymphocyte subs... |
41660513 | Development and characterization of a novel B7-H3 rabbit monoclonal antibody for glioma diagnosis. | <h4>Background</h4>Glioma is the most common primary brain tumor of the central nervous system and is associated with poor clinical outcomes, particularly in high-grade diease. The immune checkpoint protein B7-H3 (CD276) is significantly overexpressed in glioma and multiple other solid tumors, highlighting its potentia... |
41660429 | Early detection and genetic characterization of clade 2.3.4.4b H5N1 and H5N9 highly pathogenic avian influenza viruses at the onset of fall migration in wild birds during october 2025 in South Korea. | Highly pathogenic avian influenza (HPAI) viruses of clade 2.3.4.4b continue to diversify through reassortment with co-circulating low-pathogenic avian influenza (LPAI) viruses and are repeatedly introduced into South Korea via migratory flyways. During national wild bird surveillance in October 2025, two HPAI viruses o... |
41660277 | Ferroptosis and Alzheimer's disease: unraveling the molecular mechanisms and therapeutic opportunities. | Ferroptosis is a novel form of regulated cell death. Compared with other types of cell death, it shows great differences in structure and biochemistry. This type of cell death is receiving increasing attention. For example, studies have found that it plays a key role in the development of neurodegenerative diseases und... |
41660125 | Harnessing polysaccharide-mediated biomineralization for advanced bone tissue engineering. | Biomineralization is a critical process wherein organisms form mineral composites via organic-inorganic synergistic interactions, which are essential for maintaining and repairing bone tissue homeostasis. Polysaccharides, as a class of natural biological macromolecules, play a crucial role in regulating biomineralizati... |
41659880 | T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review. | T-bet is a transcription factor predominantly expressed in immune cells, and it has been associated with a range of physiological and pathological processes, including the differentiation of various immune cell types, the development of immune-related diseases, and tumor progression. Despite notable advancements in the... |
41659862 | The emerging paradigms of SETD family enzymes as epigenetic regulators of the immune response in inflammatory diseases. | Family members of the SET domain family (SETD) of histone lysine methyltransferases (HKMTs) act as principal epigenetic regulators, modulating chromatin structure, transcription pathways, and immune responses. SETDs catalyze lysine methylation on histone and non-histone substrates, as well as non-histone proteins (e.g.... |
41659853 | Anti-angiogenic therapies in cancer: from endogenous inhibitors to bispecific VEGF x PD-(L)1 antibodies. | Based on the hypothesis that neovascularization was required for tumor growth, the search for angiogenesis inhibitors attracted considerable attention, leading to the development of the monoclonal antibody bevacizumab against vascular endothelial growth factor (VEGF) which is currently standard treatment in several typ... |
41658989 | MXene-based functionalized platforms for high-performance MALDI-TOF MS: application in early-stage bloodstream infection biomarker screening. | <h4>Introduction</h4>This study developed a MALDI-TOF MS metabolomics analysis method based on MXene nanomaterial functionalization platform for early diagnosis of bloodstream infections (BSI). Currently, BSI detection mainly relies on methods such as blood culture, PCR, and single biomarkers (such as PCT, CRP), which ... |
41657778 | Improving kidney transplantation through the addition of pharmacological agents to hypothermic preservation solutions: a scoping review. | The increasing use of extended kidney grafts to bridge organ shortage has led to delayed and impaired graft function, warranting the development of new preservation strategies. In addition to hypothermic machine perfusion, the addition of pharmacological agents to preservation solutions has been primarily investigated,... |
41657734 | Advances in protein dot blot: principles, technical specifics, applications, and future perspectives. | Protein dot blot is an efficient immunoblotting technique enabling qualitative/semi-quantitative protein analysis without electrophoresis, relying on antigen-antibody binding. Its workflow involves direct sample spotting on membranes, blocking, antibody incubation, and signal detection, completing within 3-5 h. Advanta... |
41604760 | Photoelectrochemical and colorimetric dual-mode immunosensor based on Cu-BTC-stabilized hemin nanozyme for point-of-care detection of neuronal-specific enolase in serum. | As a primary cause of global mortality, cerebral stroke (CS) necessitates prompt diagnosis, where detecting neuron-specific enolase (NSE) rapidly and accurately is key to effective intervention. To resolve this issue, a novel dual-mode photoelectrochemical and colorimetric (PEC-CL) immunosensor was proposed for point-o... |
41631213 | TDP-43 in neurodegeneration and cancer: Decoding the mechanism of mRNA localization and translation. | The localization and translation of mRNAs play crucial roles in maintaining cellular phenotype and function, with RNA-binding protein (RBP) contributing significantly to these processes. TAR DNA-binding protein of 43 kDa (TDP-43) is an RNA/DNA-binding protein that is primarily localized in the nucleus, where it perform... |
41626191 | Neutral anion-detecting organic cages based on anion-π interactions. | A series of neutral tetrahedral molecular cages were self-assembled in relatively high yields by condensing a triamino linker with triangular tris-aldehyde precursors. Each tris-aldehyde features a central triazine core, which imparts an electron-deficient cavity that facilitates anion encapsulation through fourfold an... |
41626187 | Heterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines. | <i>N</i>-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving... |
41621261 | Imidazole functionalized nanozyme for deep detoxification and machine-learning-assisted intelligent sensing of profenofos. | The excessive use of profenofos (PF) poses a significant threat to ecosystems and human health, making efficient degradation and detection technologies imperative. Despite the evident promise of nanozyme-based cascade catalytic systems, integrating such systems into a single nanozyme with high reactivity remains challe... |
41619422 | Tailoring the structure of MIL-101(Fe) for co-delivery of anti-inflammatory therapeutic agents. | Treating inflammation often requires the combined use of multiple agents due to the complexity of biological pathways. Metal-organic frameworks (MOFs), with adjustable structures and high loading capacities, offer a promising route for dual-drug delivery. However, designing MOF-based systems that can simultaneously inc... |
41616525 | NIR-triggered synergistic Photothermal therapy and type I photodynamic therapy using supramolecular porphyrin-Phthalocyanine assemblies for the treatment of multidrug-resistant bacterial infections. | Multidrug-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), pose a severe global health threat exacerbated by the limitations of conventional antibiotics and the hypoxic microenvironment of infections. To address this, we developed a novel supramolecular photosensitizer, TAPc@T... |
41610651 | Biomimetic red blood cell membrane-coated cerium metal-organic framework for multi-target synergistic therapy of Alzheimer's disease. | Pathological events in Alzheimer's disease (AD) typically involve β-amyloid (Aβ) plaque deposition, metal ion dysregulation, oxidative stress elevation, and chronic neuroinflammation, making single-target therapies unsatisfactory. Here, we first report a biomimetic nanoplatform based on red blood cell membrane-coated c... |
41610528 | Sensitive lateral flow immunoassay based on the use of Au@Pt nanozyme and aptamer-captured oriented antibodies for the detection of anti-Müllerian hormone. | The application of core@shell nanozymes as labeling materials integrating catalytic amplification with molecular recognition in immunoassay platforms is a challenging task, since antibody immobilization often reduces both antibody reactivity and nanozyme catalytic activity. In this work, an approach to the oriented imm... |
41602176 | Self-assembling nanocomposites for smart drug delivery: towards personalized and stimuli-responsive therapeutics. | Self-assembling nanocomposites (SANCs) represent a valuable and innovative drug delivery system that facilitates site-specific and stimulus-controlled drug administration. These composites have the capability to self-assemble into stimulus-responsive nanostructures, enabling the effective delivery of a wide range of th... |
41584131 | Functionalization of carbon nanospheres with curcumin, polyethylene glycol and folic acid: potential use as drug carriers. | This study reports the synthesis of carbon nanospheres (CNS) modified by anchoring curcumin (CUR), polyethylene glycol (PEG) and folic acid (FA) on their surface as a drug delivery system (DDS) for potential applications in cancer therapy. CNS were synthesized <i>via</i> chemical vapor deposition (CVD) while CUR and PE... |
41584123 | Deep eutectic solvents in E-waste recycling: preparation, properties, and hydrometallurgical metal recovery. | Deep eutectic solvents (DESs) are promising green solvents for hydrometallurgical metal recovery, formed by heating and mixing hydrogen bond donors and acceptors in specific molar ratios, where hydrogen-bond network formation rather than chemical reactions depresses the melting point and yields a stable, tuneable liqui... |
41584114 | Out-of-distribution evaluation of active learning pipelines for molecular property prediction. | Active learning (AL) has been widely applied as a strategy to reduce the data requirements of training machine learning models. Such a strategy can be especially valuable in fields where data collection is costly or time-consuming, as is the case for molecular property data. In this study, we evaluate AL for molecular ... |
41584112 | Engineering combination nanomedicines to overcome cancer resistance. | Combination nanomedicine enables the coordinated delivery of multiple therapeutic agents using engineered nanosystems to address tumor heterogeneity, multidrug resistance, and systemic toxicity. Despite extensive preclinical progress, many combination nanomedicine strategies fail to translate clinically due to poor pha... |
41583392 | Electroresponsive Strategies to Combat Bacterial Infections. | Drug-resistant bacterial infections threaten global health and economies. Stimulus-responsive antibacterial materials are promising for combating resistance and improving treatment precision. Among them, electroresponsive strategies stand out for being practical, economical, tunable, and safe. This perspective examines... |
41583390 | Ubiquitin D Promotes Lung Metastasis by Stabilizing MMP3 in Triple-Negative Breast Cancer. | Triple-negative breast cancer (TNBC) represents a notably aggressive form of breast cancer, distinguished by heightened invasiveness and an important propensity for metastasis. The expression of ubiquitin D (UBD) is significantly increased in lung metastases associated with TNBC, correlating with unfavorable patient ou... |
41584138 | Exploring the changes in anticoagulant active ingredients before and after bovine bile fermentation of the traditional Chinese medicine Yaomu <i>via</i> an aggregation-induced emission fluorescence sensor. | Fermentation is a significant and specialized processing technology that primarily serves to enhance efficacy and reduce toxicity. Yaomu (YM) was fermented in a cellar using bovine bile as the fermentation matrix. However, the alterations in its active ingredients before and after processing remain poorly understood. A... |
41584130 | Permanent electrostatic moments through the lens of atoms: assessing variational Hirshfeld methods. | Atomic multipoles are key components of many computational models; however, there is no unique method for computing them. This motivates our benchmark study to evaluate how accurately the atomic moments from variational methods approximate the molecular moments, offering insight into their ability to capture the underl... |
41581884 | Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites. | Non-structural protein 13 (nsp13), the Coronaviral RNA helicase, is an attractive antiviral target due to its importance in viral genome replication and highly conserved nature. Nsp13's processive dsRNA unwinding is driven by ATP hydrolysis in the nucleotide triphosphatase active site, which provides mechanical energy ... |
41581882 | Antagonist nanobodies prevent protease inhibition by CD109. | Cluster of differentiation 109 (CD109) is a cell surface protein found on many human cell types, including keratinocytes, platelets, and T-cells. It is a protease inhibitor of the α-macroglobulin protein superfamily and is reported to affect signaling pathways such as TGFβ and STAT3. Here, we characterized two CD109-sp... |
41581865 | Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5. | G-protein-coupled receptors (GPCRs) display bias toward either G proteins or GPCR kinase (GRK)-mediated β-arrestin (βarr) signaling depending on the agonist-stabilized receptor conformation. The cellular context and subcellular location of GPCRs can also influence biased signaling through mechanisms that are not well u... |
41581814 | New hybrid polyhedral oligomeric silsesquioxanes as triple-acting promoters of polylactide crystallization - their synthesis using latent thiols and studies of their thermal behavior. | New hybrid polyhedral oligomeric silsesquioxanes (POSS) were designed as additives to enhance the crystallinity of polylactide (PLA) by combined effect of heterogeneous nucleation, supramolecular interactions and plasticization. The synthetic strategy involved the opening of N-acetylaminothiolactone ring (a latent thio... |
41581807 | Multifunctional hyaluronic acid-decorated polyamidoamine dendrimers enhance drug solubility and enable precision therapy for ulcerative colitis. | The therapeutic management of inflammatory bowel disease (IBD) remains challenging by poor drug bioavailability, limited mucosal targeting, and chronic immune dysregulation. In this study, we report the synthesis and characterization of hyaluronic acid (HA)-decorated polyamidoamine (PAMAM) dendrimers as a multifunction... |
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