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41581716 | Reprogramming lysosomal-purinergic crosstalk governs the synergistic attenuation of NLRP3 inflammasome activation by cyclodextrin-P2X7 blockade in diabetic rats. | Steatohepatitis links cholesterol-crystal injury to ATP-gated purinergic signaling, culminating in NF-κB/NLRP3 inflammasome activation and metabolic dysfunction. We posited that dissolving cholesterol burden while concurrently blocking P2X7 would reprogram lysosomal-purinergic crosstalk and outperform single-pathway th... |
41579737 | Ultrasensitive colorimetric/fluorescence dual-mode sensing platform based on quasi-NENU-5 for specific detection of glyphosate. | Herein, a colorimetric/fluorescence dual-mode sensor was developed for ultrasensitive detection of glyphosate, utilizing a Cu-based quasi-metal-organic framework NENU-5 (QN-5) and green-emissive carbon dots (GCDs). QN-5 mimics laccase activity by catalyzing the conversion of oxygen (O<sub>2</sub>) into superoxide radic... |
41579411 | Computational design of intrinsically disordered proteins. | Protein design has the potential to revolutionize biotechnology and medicine. While most efforts have focused on proteins with well-defined structures, increased recognition of the functional significance of intrinsically disordered regions, together with improvements in their modeling, has paved the way to their compu... |
41578437 | Enantioselective Determination of Amphetamine-Type Stimulants in Environmental Waters Using SPE and CE-MS/MS. | The growing concern over drug abuse, particularly involving amphetamine-type substances (ATS), has led to their monitoring in environmental waters. These chiral compounds, commonly found in river water and wastewater treatment plant (WWTP) effluents, require analytical methods capable of enantiomeric discrimination, as... |
41578380 | COLEC10 and COLEC11 are new serum biomarkers of chronic liver disease. | <h4>Background</h4>COLEC10 and COLEC11 are presumed to act as pattern recognition receptors to activate the complement system by binding to MASP1. However, it is not clear whether the serum concentrations of COLEC10, COLEC11 and MASP1 can be diagnostic markers of chronic liver disease (CLD).<h4>Aims</h4>This study aime... |
41578333 | Sorafenib nanomedicine in HCC: nano-bio interactions and combination therapies. | Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with systemic therapies offering only limited benefit. Sorafenib, the first-line multi-kinase inhibitor, is constrained by poor pharmacokinetics, dose-limiting toxicities, and the rapid emergence of resistance. Nanotechnology-... |
41578094 | Structurally Modified Cyclodextrins in Topical Nanotechnology: Advancing Barrier-Penetrating Drug Delivery Strategies for Psoriasis Management. | Psoriasis is a chronic inflammatory skin condition characterized by the hyperproliferation of keratinocytes that results in erythematous and scaly plaques on the epidermal surface. Conventional therapeutic approaches exhibit drawbacks such as inadequate skin penetration, low drug bioavailability, and undesirable side e... |
41578025 | N-Glycosylation of Band 3 is essential for the binding of Ganoderma lucidum immunomodulatory protein rLZ-8. | Fungal immunomodulatory proteins (FIPs) are considered potential therapeutic candidates due to their immunomodulatory and anti-cancer activities. Meanwhile, they are capable of agglutinating mammalian red blood cells in a manner similar to lectins. Herein, GST-tagged rLZ-8, the first identified FIP in Ganoderma lucidum... |
41578024 | Metabolite diversity of Microcystis strains shows tight correspondence to genotype and may contribute to ecotype specificities. | Microcystis is one of the most common bloom-forming cyanobacteria colonizing freshwater ecosystems worldwide. This genus remarkably produces numerous bio-active accessory metabolites, which are believed to be potentially involved in different ecological and/or physiological processes. However, their genuine contributio... |
41578000 | Chirally locked and dynamic bis-perylene diimide macrocycles with multiple sources of chirality. | Chiral organic materials show great promise in optoelectronics, sensing and catalysis. Among those, macrocycles are of great interest due to their preorganisation and potential amplification of chiroptical properties. Understanding the effects of different sources of chirality on the resulting chiroptical properties of... |
41577843 | The photolytic and photocatalytic activity of TiO<sub>2</sub> doped Zn₄O(BDC)₃ nano MOF for removing cyprodinil fungicide residues from hard water. | The TiO₂-doped Zn₄O(BDC)₃ MOF (Metal-organic framework) revealed an exceptional capacity to decompose cyprodinil fungicide residues in water under simulated sunlight conditions. It was synthesized using autoclave methods. A solution containing 0.2 mmol of zinc nitrate (Zn (NO₃)₂), 0.2 mmol of titanium isopropoxide (TTI... |
41577731 | In silico evaluation of (benzo)chromeno[3,4-c]pyridine derivative as dual EGFR/HER2 inhibitors for non-small cell lung cancer. | (Benzo)chromeno[3,4-c]pyridine derivatives continue to attract significant scientific interest due to their broad pharmacological relevance, especially in cancer chemotherapy. In this study, both experimental and density functional theory (DFT) based computational approaches were employed to investigate the structural,... |
41577709 | Atomically tweaking spin-crossover cooperativity to augment molecular memory density. | Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability. However, it's a formidable challenge to turn densely packed spin-crossover molecules into high-density bits due to cooperative switching dynamics inherent in spin-crossover aggregates. Herein, coordination-field en... |
41577706 | Two types of axonal muscarinic acetylcholine receptors mediate formation of saliva cocktail in the tick Ixodes ricinus. | Hard ticks depend upon an ability to precisely and dynamically regulate their saliva to successfully evade host haemostatic and immune defences during extended blood feeding. Although pilocarpine, an exogenous muscarinic acetylcholine receptor (mAChR) agonist, can stimulate salivation experimentally, the endogenous con... |
41577690 | Plant fucosyltransferase FUT11 distorts the sugar acceptor to catalyze via a transient oxocarbenium intermediate mechanism. | Glycosyltransferases catalyze glycosidic bond formation by activating the donor sugar, while the sugar acceptor substrate is considered passive, maintaining a chair conformation during catalysis. We challenge this through a multidisciplinary study of Arabidopsis thaliana FUT11, a core α1,3-fucosyltransferase essential ... |
41577678 | Unravelling the nucleation-elongation mechanism of one-pot catenation. | The formation of catenanes through dynamic covalent reaction of self-assembling precursors in one pot offers a powerful route to complex interlocked architectures, yet the mechanistic insight remains underexplored. Here, we elucidate the nucleation-elongation mechanism in the one-pot synthesis of topologically distinct... |
41576923 | Evaluation of Trilysine-Cross-Linked Gellan Gum for Intratumoral Delivery of Anti-PD-1 in a Colorectal Cancer Mouse Tumor Model. | Colorectal cancer (CRC) is the second leading cause of death in the United States in the adult population. When detected at early stages, the survival rate is higher than 70% but when diagnosed at a metastatic stage, the 5-year survival rate significantly declines to 15%. In recent years, immunotherapy has shown promis... |
41576283 | Solubility and Metastability of the Amyloidogenic Core of Tau. | Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer's disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the sys... |
41576204 | Structural Insights into N,N-Diethyl-2-hydroxyacetamide Using Matrix Isolation Infrared Spectroscopy and DFT Computations: Conformational Control through Intramolecular Hydrogen Bonding and Hyperconjugation. | The conformational space of N,N-diethyl-2-hydroxyacetamide (DEHyA) was elucidated through an integrated experimental-computational approach combining matrix isolation infrared spectroscopy and density functional theory (DFT) calculations. Quantum chemical analysis revealed 15 distinct conformers, with the CC(g<sup>±</s... |
41576171 | Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain. | Bone metastasis remains a formidable challenge in oncology due to the interdependent triad of immunosuppression, neuropathic pain, and osteolytic destruction. Current treatments fail to holistically address these pathophysiological axes. Here, we develop a reactive oxygen species (ROS)-responsive liposomal nanoplatform... |
41576152 | GC-MS based bioactive profiling of Phyllanthus niruri and its antibacterial potential through experimental and computational studies. | <h4>Objective</h4>The study aimed to evaluate the antibacterial potential of Phyllanthus niruri by identifying its bioactive compounds through GC-MS, assessing their in vitro antibacterial efficacy, and validating their interactions with bacterial target proteins through molecular docking and pharmacokinetic analyses.<... |
41576151 | Molecular mechanism of ziresovir targeting the fusion glycoprotein of respiratory syncytial virus. | Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and the elderly worldwide. Although prophylactic monoclonal antibodies and RSV vaccines are available for preventing severe RSV infection, unmet medical need remains for an effective antiviral agent to treat patients w... |
41576078 | Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2. | Topoisomerase enzymes are essential for the regulation of DNA topology. Human topoisomerase IIIα is a Type 1A topoisomerase that exists as a complex with RMI1 and RMI2, known as TRR. The TRR complex can unlink entwined DNA strands and is known to be important for resolving DNA replication and recombination intermediate... |
41576007 | A novel template-free synthesis of Na-A Zeolite for enhanced removal of heavy metals from aqueous solutions. | The removal of toxic heavy metals from wastewater remains a major environmental challenge due to their non-bio-degradability, persistence, and adverse health effects. In this work, a novel DES-assisted microwave hydrothermal route was developed for the rapid synthesis of hierarchical Na A. zeolite (NaAZ), offering a ne... |
41576001 | Preventive effect of bentonite against pyoderma via direct binding capability of staphylococci. | Bentonite, a naturally occurring clay mineral, is widely used for detoxifying mycotoxins and chemical contaminants, yet its potential interactions with microorganisms remain poorly characterized. Staphylococci, including Staphylococcus aureus in humans and Staphylococcus pseudintermedius in dogs, are major contributors... |
41575983 | Dual-Pore Dodecanuclear Al-Oxo Cluster-Based Bimetallic Isonicotinate Frameworks for Selective Propylene/Ethylene Separation. | The separation of ethylene (C<sub>2</sub>H<sub>4</sub>) and propylene (C<sub>3</sub>H<sub>6</sub>) from methanol-to-olefins (MTO) products remains challenging due to their similar physicochemical properties, whereas conventional cryogenic distillation is energy-intensive. This study addresses the need for cost-effectiv... |
41575978 | Formation of Ultrasmall Noble Metal Alloy Nanocrystals in Microdroplets. | Alloy nanocrystals (NCs) have attracted considerable attention due to their broad applications. Herein, we present examples of ultrasmall (<5 nm) noble metal alloy NCs, i.e., AuPd and PdPt NCs, synthesized by sprayed water microdroplets. Electrons generated at the air-water interface of microdroplets serve as the prima... |
41575943 | Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. | Clade 2.2 H5N1 influenza viruses have caused an unusually high number of human infections, providing a unique opportunity to investigate early molecular steps associated with host adaptation. Although most work has focused on hemagglutinin (HA), the contribution of neuraminidase (NA) to these early adaptive events has ... |
41575934 | In silico evaluation of bioactive compounds from the sea urchin Temnopleurus toreumaticus: Potential multifunctional agents against mosquito vectors and tropical pathogens. | This study investigates the ethanolic extract of the sea urchin Temnopleurus toreumaticus (test and spine) for its larvicidal efficacy against Aedes aegypti, cytotoxicity, and in silico interactions supporting potential antimalarial and antiviral activities. Zoochemical profiling by Fourier-transform infrared spectrosc... |
41575786 | Dual-Enzyme Responsive Polymeric Micelles with Cascade Targeting and Caspase-3 Activated Drug Release for Tumor-Specific Chemotherapy. | Cancer, as a global health crisis, continues to threaten human life and health. Chemotherapy occupies a central position in cancer treatment, but conventional chemotherapeutic agents have some limitations, such as low solubility, lack of specific targeting, insufficient bioavailability and high toxicity to normal tissu... |
41575760 | Chiral Cascade-Targeted Nanoassembly Eradicates Intratumoral Bacteria via Ferroptosis to Potentiate STING-Driven Antitumor Immunity. | Intratumoral bacteria, particularly those residing intracellularly, are emerging as critical regulators of tumor progression and immunosuppression, yet their precise eradication and conversion of this process into an immunostimulatory signal remain a formidable challenge. Here, we report a chiral supramolecular nanoass... |
41575741 | Quantifying the Substituent Effects on O-H···O Hydrogen Bonding Dominance in Hydroxylic Dimers: A Rotational Spectroscopic and Topological Study of the 2-Butyn Alcohol Dimer. | Hydrogen bonds are fundamental interactions that govern molecular aggregation. Although the O-H···O hydrogen bond is dominant in simple hydroxylic dimers, how this dominance is perturbed by substituents remains a key question. This study investigates the 2-butyn alcohol dimer using pulsed-jet Fourier transform microwav... |
41575671 | Self-healing hydrogels: mechanisms and applications in biomedical and environmental fields. | This review offers a critical synthesis of the rapidly developing topic of self-healing hydrogels, focusing on the unresolved trade-off between healing efficiency and mechanical robustness that currently restricts their practical application. By systematically analyzing the literature on dynamic covalent (e.g., Schiff ... |
41575608 | Hydroxyapatite-cellulose composites: properties, fabrication methods, and applications. | Hydroxyapatite-cellulose (HAp-cellulose) composites blend the bioactivity of HAp with the flexibility and biodegradability of cellulose, offering promise in biomedical and industrial fields. In healthcare, they aid bone regeneration, drug delivery, and tissue engineering due to their biocompatibility and porosity. Indu... |
41575294 | Decoding plant defense signaling using the defenseless mutant. | Can plants live without defenses? Mutant analysis in Arabidopsis thaliana has identified numerous regulators of biotic, abiotic, and hormone-based defenses, but the redundancy among separate defense pathways remains unexplored. We constructed an Arabidopsis mutant, defenseless, lacking six canonical defense pathways us... |
41575198 | <i>In vitro</i> and <i>in vivo</i> antimicrobial activity of protoberberine alkaloids as novel therapeutic candidates against <i>Mycoplasma hyopneumoniae</i>. | <i>Mycoplasma hyopneumoniae (M. hyopneumoniae,</i> Mhp), the primary causative agent of swine enzootic pneumonia, poses significant threats to the pork industry, challenging food safety and sustainable development of the livestock industry. Here, four protoberberine alkaloids-epiberberine, jatrorrhizine, berberine, and... |
41575159 | Interfacial Behavior, Supramolecular Assembly, and Photophysics of Phospholipid-Porphyrin and Phospholipid-Phthalocyanine Conjugates. | The design of supramolecular assemblies based on phospholipid-porphyrinoid conjugates has attracted growing attention in recent years, particularly for biomedical applications. Here, we report two novel amphiphilic conjugates, ZnPor(PL)<sub>4</sub> and ZnPc(PL)<sub>4,</sub> obtained by coupling four molecules of 1-myri... |
41575172 | Application Advantages of MOF Materials Constructed of Different Metals in Dynamic Therapy of Tumors: Analysis and Elaboration. | Cancer is a disease that is difficult to treat effectively worldwide and is also one of the main causes of death for many patients. Its complex biological characteristics and pathological mechanisms pose significant challenges, limiting the effectiveness and safety of traditional treatments, such as surgery, radiothera... |
41574974 | The Effect of Allosteric Conformational Regulation on the Crystal Packing of Aromatic Amide Metallomacrocycles via Ligand-Modulated Remote Intramolecular Hydrogen Bonds. | The versatility of supramolecular chemistry stems from rational molecular design, which allows for the precise control over noncovalent interactions to direct self-assembly processes. Inspired by allosteric regulation in biomolecules, where long-range interactions dictate function, we report a novel aramide macrocyclic... |
41574975 | Tailoring Square-Shaped 2D Mesoporous Nanosheets via an Interface-Confined Anisotropic Assembly Strategy. | Despite considerable advancements in the synthesis of two-dimensional (2D) mesoporous nanomaterials, achieving precise control over their components, morphology, lateral dimension, and thickness remains a formidable challenge. Here, we report a rational interface-confined anisotropic assembly strategy that enables the ... |
41574923 | Medium-Sized-Molecule Encapsulation in Coordination Cages via Solid-State Mechanochemistry. | The encapsulation of medium-sized molecules in synthetic hosts remains a major challenge, hindered by both the lack of suitable hosts that combine a large size with high molecular recognition capability and kinetic and thermodynamic barriers to encapsulating bulky molecules in solution. Here, we demonstrate that solid-... |
41574830 | Room Temperature Photodriven Ru(II)-Tripyridine Supramolecular Photosensitizer Synergistically Catalyzes Carbon Dioxide Cycloaddition with Metal Nanoclusters. | Photocatalytic CO<sub>2</sub> cycloaddition under mild conditions is of great significance for achieving renewable carbon resource recycling and environmental protection. To enhance the efficiency of this light-driven conversion process, this study constructed an efficient photocatalytic system composed of a photosensi... |
41574727 | Aspartame Peptide-Based Piezoelectric Supramolecular Material Toward Energy Harvesting. | Peptide assemblies with non-centrosymmetric structures have been developed as piezoelectric supramolecular materials toward nanotechnology. However, the variety of peptide-based piezoelectric materials remains limited. Herein, for the first time, we have explored the piezoelectric properties of aspartame dipeptide-base... |
41574708 | Mangiferin in human disease: Multifaceted mechanisms and applications (Review). | Mangiferin (MGF) is a natural C‑glucosyl xanthone with multitarget activity relevant to metabolic, inflammatory and cancer diseases. Notably, MGF modulates AMP‑activated protein kinase, NF‑κB, PI3K/AKT and MAPK signaling; through these pathways, it affects glucose and lipid metabolism, oxidative stress, apoptosis and i... |
41574690 | Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review). | Sepsis, an infection‑triggered systemic inflammatory response syndrome, ranks as the third leading cause of death worldwide due to its high incidence and mortality. Sepsis‑induced myocardial dysfunction (SIMD) is a frequent and serious complication that notably increases patient morbidity and mortality. The underlying ... |
41574566 | Stacking Order-Mediated Spin-State Modulation in Iron Phthalocyanine Covalent Organic Frameworks Enables Efficient Oxygen Reduction Reaction. | Covalent organic frameworks (COFs) such as iron phthalocyanine (FePc) have been considered as potential electrocatalysts. Herein, we provide important insights into modulating the intrinsic activity of FePc COFs for the oxygen reduction reaction (ORR) by adjusting their stacking configuration. The eclipsed, AA-stacked ... |
41574481 | Ce-Doped Lignin-Based Nanozyme with Heat-Activated Hydrolase Activity. | Nanozymes are powerful alternatives to natural enzymes, yet the sustainable design of hydrolase nanozymes using renewable ligands remains underexplored. Lignin, as an abundant aromatic biopolymer, offers a promising and green ligand for constructing sustainable nanozymes. In this work, a Ce-doped lignin-based hydrolase... |
41574450 | Gut microbiota in early and established stages of rheumatoid arthritis: from pathogenesis to promising prevention and treatment. | <b>Background</b>: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease whose etiology is not fully understood. Before overt disease, genetically prone individuals may undergo a lengthy pre-clinical phase during which loss of tolerance triggers autoantibody emergence. The gut-joint axis was proposed d... |
41572955 | Molecules and Linear Polymers With Incorporated Pillar[5]Arene Units: Enhanced Aggregation-Induced Emission and Their Applications. | Pillar[n]arenes are a class of special macrocyclic compounds with rigid and porous structures, representing an important branch of host macrocycles in the field of supramolecular chemistry. Since their discovery in 2008, pillar[n]arenes have been in-depth applied in the field of biomedicine, such as molecular recogniti... |
41572951 | Ultrasound-Triggered Type I Supramolecular Photosensitizer for Precise In Situ Chemiluminescence-Based Photodynamic Cyclic Therapy. | Chemiluminescence-based photodynamic therapy (CL-PDT) addresses the challenge of traditional PDT regarding limited light penetration depth. However, its therapeutic efficacy is constrained by the efficiency of chemiluminescence resonance energy transfer (CRET) and CL intensity. Herein, we introduce a hypocrellin deriva... |
41572929 | Understanding the Role of H-Bonds in the Stability of Molecular Glue-Induced Ternary Complexes. | Protein-protein interaction (PPI) networks play a central role in many biological processes, and thus, the possibility of modulating them using small molecules offers several therapeutic opportunities. Molecular glues (MGs) are small molecules that bind to a PPI interface and stabilize the complex. Oftentimes, MGs show... |
41572912 | Beyond the Multicomponent Debus-Radziszewski Route: Two-Component Cyclocondensation Constructing a 12 + 3-Connected aea Topology Three-Dimensional Imidazole-Linked COF for Sustainable Wastewater Treatment. | The rational construction of high-connectivity three-dimensional covalent organic frameworks (3D COFs) remains a central challenge in reticular chemistry, holding immense promise for advancing framework rigidity, porosity, and functional integration. From both fundamental and application standpoints, diversifying the l... |
41572893 | Revisiting MOF-Derived Single-Atom Electrocatalysts: Limitations, Characterizations, and Design Strategies. | Single-atom sites (SASs) and their electrocatalysts offer outstanding catalytic activity and metal efficiency. Metal-organic frameworks (MOFs), with their tunable and multifunctional architectures, serve as ideal precursors for SASs, enabling atomic-level dispersion. However, current research often overlooks critical a... |
41572894 | Molecular Design in l-Glutamic Acid-Based Peptide Assembly Dynamics Driven by Carbodiimide-Fueled Reaction Cycle. | Molecular self-assembly creates complex structures through noncovalent interactions. Synthetic fuel-driven systems mimic biology, yet the effects of subtle design changes, particularly hydrophobic groups such as alkyl chains, are still not well understood. This study showed that the alkyl chain length critically influe... |
41572879 | <i>Porphyra tenera</i> an Edible Red Alga Inhibits Norovirus P Domain Binding to the Host Cell Receptor. | <i>Porphyra tenera</i> (PT), an edible red alga, is consumed as a health-promoting seaweed. Human norovirus (HuNV), the major cause of foodborne disease outbreaks worldwide, binds to histo-blood group antigens (HBGAs) for cell entry. We investigated the inhibitory activity of fucose-containing polysaccharides in PT on ... |
41572883 | Construction of Heteroleptic Copper Complexes in Perylene Diimide-Based COFs for Heterogeneous Metallaphotoredox Catalysis. | Despite recent advances in developing diimine-containing copper photocatalysts for organic synthesis, further exploration of heteroleptic phenanthroline-ligated copper complexes remains challenging due to rapid ligand exchange in homogeneous solutions. Herein, we employ a framework-based heterogenization strategy to su... |
41572085 | Interpretable machine learning-driven QSAR modeling for coagulation factor X inhibitors: from molecular descriptors to predictive potency. | Inhibition of Coagulation Factor X (FXa) is a clinically validated therapeutic strategy; however, developing safer and more selective inhibitors remains a major challenge. In this study, we developed an interpretable machine learning-based QSAR framework to predict both the inhibitory potency and activity class of smal... |
41571694 | Homotypic membrane-powered electrochemical microfluidic analysis of extracellular vesicles for precise cancer diagnosis. | The cancer cell membrane, rich in tumor-associated antigens, effectively replicates the characteristics of cancer cells by presenting specific protein profiles. Leveraging the inherent binding capability of the cancer cell membrane, here we show a homotypic membrane-powered biomimetic interface for subtype-specific ana... |
41909733 | Membrane-derived biomimetic nanovesicles in anti-tumor immunotherapy: Advances and outlook. | Membrane-derived biomimetic nanovesicles have emerged as a promising platform in cancer immunotherapy due to their intrinsic biocompatibility, functional plasticity, and capability to modulate immune responses. By integrating various immunotherapeutic agents, including immune checkpoint inhibitors, tumor antigens, and ... |
41909755 | Heterocyclic modified paclitaxel prodrug nanoassemblies for stimuli-responsive delivery <i>via</i> lysosomal escape. | Prodrug nanoassemblies offer an innovative approach to drug delivery, but their lysosomal entrapment often impairs drug release. Notably, tertiary amine structures can undergo protonation reactions, thereby facilitating lysosomal escape through the proton sponge effect. In this study, we developed three novel paclitaxe... |
41909736 | Targeting immunosuppressive network in glioblastoma: Emerging strategies to overcome immunodeficiency and enhance therapeutic efficacy. | Glioblastoma (GBM), the most aggressive primary brain tumor, remains a formidable therapeutic challenge, with a median survival under 15 months. Despite the current standard of care-comprising maximal safe surgical resection, radiotherapy, and temozolomide chemotherapy-patient outcomes have seen minimal improvement ove... |
41909615 | Minor groove tetrads: a potent and versatile capping interaction for i-motif structures. | Minor groove tetrads (MGTs) have emerged as powerful structural elements capable of enhancing the stability and versatility of i-motif DNA structures. These non-canonical tetrads, formed by the minor groove association of two Watson-Crick or mismatched base pairs, act as capping platforms that reinforce hemiprotonated ... |
41907374 | Novel Strategies for Precision Diagnosis and Treatment of Prostate Cancer Based on Multifunctional Nanocarrier Systems. | Prostate cancer (PCa) is one of the most common malignancies in men worldwide, and its current diagnostic and therapeutic methods still face severe challenges in terms of specificity, efficacy, and toxicity. The emergence of nanotechnology provides a powerful platform to overcome these obstacles. Through the design of ... |
41890398 | A Thermodynamically Consistent Formulation of the Fundamental Equation in Inverse Gas Chromatography for an Accurate Determination of Solid Surface Properties. | The classical theory of inverse gas chromatography (IGC) assumes that adsorbed probe molecules behave as a perfect two-dimensional gas, a simplification that leads to large systematic errors in the surface energy and Lewis acid-base calculations. We introduce a corrected formulation for the Gibbs free energy of adsorpt... |
41878684 | Therapeutic Efficacy of Curcumin Nanoparticles in Parkinson's Disease: An Integrated Analysis of Network Pharmacology, Experimental Validation, and Gut Microbiota. | <h4>Background</h4>Parkinson's disease (PD) ranks as the second most common neurodegenerative condition globally, with a rising occurrence alongside the aging demographic. Previous studies have demonstrated that curcumin monomers can alleviate PD symptoms and slow disease progression, whereas nano-drug delivery systems... |
41869402 | The Dual-Faceted Role of Metal-Based Nanomaterials in Hepatic Fibrosis Therapy. | Hepatic fibrosis represents a pivotal transitional stage between hepatitis and cirrhosis or hepatocellular carcinoma, predominantly mediated by hepatic stellate cells (HSCs) activation, dysregulated extracellular matrix (ECM) deposition, and oxidative stress. Metal-based nanomaterials (MNMs) exhibit dualistic effects i... |
41737124 | A Time-Based and Clinical Status Stratified Protocol for Major Bile Duct Injury After Cholecystectomy: Retrospective, Single-Center Outcomes From a Resource-Limited Setting. | Background The management of major iatrogenic bile duct injury (BDI) (Strasberg types D and E) is critically influenced by the timing of repair and patient physiology, posing a significant clinical challenge in resource-constrained environments. This study aimed to determine the optimal timing for surgical intervention... |
41710746 | SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13<sup>Pru</sup> Degrader. | Proteolysis-targeting chimeras (PROTACs) and degraders have been developed against the hRpn13 fragment hRpn13<sup>Pru</sup> that is present in various cancer types. Testing the performance of these hRpn13<sup>Pru</sup>-targeting compounds in pharmacokinetic and efficacy studies has been stymied, however, by their poor ... |
41705035 | Crystallographic visualization of C3-hydrocarbon-induced structural transformation and guest encapsulation within a flexible coordination network. | Flexible coordination polymers that can self-adjust, <i>via</i> closed (nonporous) to open (porous) switching, to match the size/shape of guest molecules are of particular interest. Herein, we report that C3 hydrocarbons can trigger a flexible SIFSIX network, [Cu(SiF<sub>6</sub>)(L)<sub>2</sub>] <sub><i>n</i></sub> (L ... |
41694599 | Epigenetic Reprogramming of Erythroid Progenitor Cells: Insights for Enhancing Cancer Immunotherapy. | Cancer immunotherapy has markedly improved clinical outcomes for cancer patients. However, its broad application is constrained by low response rates, which limit therapeutic benefits to only a subset of individuals. A deeper understanding of the tumor microenvironment (TME) and the interactions between tumor and immun... |
41668971 | Roadmap of Flexible Electrodes for Next-Generation Wearable Electronics. | With the rapid growth of smart innovations, flexible electronics recognized for their lightweight, tremendous flexibility, and extraordinary scalability are growing more integrated into our daily life. Flexible electronics, known for their lightweight, high flexibility, and seamless integration with biological and nonb... |
41660617 | Structure-guided design of a bivalent SARS-CoV-2 mRNA vaccine with NTD stabilizing mutations enhances broad immunity. | SARS-CoV-2 evolution, particularly the emergence of Omicron variants, has challenged vaccine efficacy, necessitating antigens with broad and variant-specific protection. To design mRNA vaccine antigens with broad-spectrum immunity and enhanced stability, we developed two spike antigens using <i>in silico</i> optimizati... |
41660417 | Egg-based nutrient delivery system: advances in omega-3, antioxidant, and micronutrient enrichment. | Eggs are nutrient-dense, animal-derived foods with significant health-promoting properties. Beyond providing high-quality protein, their unique structure and balanced nutrient matrix make them ideal carriers for omega-3 polyunsaturated fatty acids, antioxidants, and essential micronutrients. This review summarizes curr... |
41660116 | Sequential delivery of sinigrin and dabigatran by an <i>in situ</i> self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration. | Intervertebral disc degeneration (IDD) is characterized by an imbalance between nucleus pulposus catabolism and anabolism, driven by metabolic dysfunction of nucleus pulposus cells (NPCs) and a chronic inflammatory microenvironment. Effective treatments for IDD are lacking. Here, we report an injectable hydrogel that a... |
41659810 | Gut microbiota, liver disease, and perioperative anesthesia: interactions, risks, and therapeutic opportunities. | Liver disease is increasingly common worldwide and poses significant challenges during anesthesia and surgery. Growing evidence demonstrates that the gut microbiome plays an essential role in hepatic inflammation, metabolic imbalance, immune dysfunction, and the progression of conditions such as metabolic associated st... |
41659016 | Smart nanoplatforms for early detection and immune modulation in lung cancer. | Lung cancer is a major cause of cancer related mortality due to delayed diagnosis and limited therapeutic efficiency. Early detection and effective immune modulation are important to control lung cancer. Advancements in nanotechnology have improved oncology due to sensitive, specific, and minimally invasive detection p... |
41659011 | Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems. | Gene and genome editing therapies are increasingly connected with nanomaterials, which protect and transport fragile nucleic acids and CRISPR/Cas systems through biological barriers safely and accurately. This review discusses how different nanocarriers, including lipid-based, polymeric, inorganic, and vesicle-derived ... |
41658983 | Light force-powered cellular medical micromachines. | With the synergistic advancement of micro/nanotechnology and intelligent control systems, medical micromachines are emerging as promising alternatives to conventional diagnostic and therapeutic methods, offering enhanced operational precision and minimal invasiveness for precision medicine applications. However, most e... |
41658974 | Extracellular vesicles in Niemann pick disease type C: current knowledge and future opportunities. | Niemann Pick Disease Type C (NPC) is a rare neurodegenerative disease that primarily affects children. It is caused by mutations in the <i>NPC1</i> or <i>NPC2</i> genes, which encode proteins that transport cholesterol out of the endolysosomal organelles. Endolysosomal compartments also produce extracellular vesicles (... |
41658548 | Machine vision-based detection method for key phenotypic information of shiitake mushroom stipes. | <h4>Introduction</h4>In the field of shiitake mushroom breeding, the difficulty and inaccuracy in measuring key stipe traits severely limit improvements in breeding efficiency and product quality. This study aims to address this technical challenge.<h4>Methods</h4>A key trait detection method for mushroom stipes based ... |
41658212 | Effect of Nucleating Agent on Crystallization of Poly[(<i>R</i>)‑3-hydroxybutyrate-<i>co</i>-(<i>R</i>)‑3-hydroxyhexanoate]. | The effect of pentaerythritol (PERT) as a nucleating agent on the crystallization behavior of poly-[(<i>R</i>)-3-hydroxybutyrate-<i>co</i>-(<i>R</i>)-3-hydroxy-hexannoate] (P-(3HB-<i>co</i>-3HH)) was examined. Isothermal crystallizations with and without PERT at various temperatures were monitored in real time using si... |
41658209 | Impact of Copper Ions on the Structuration of the Polydopamine Layer for the Functionalization of Graphene Nanoplatelets. | Graphene and its derivatives, such as graphene nanoplatelets (GNPs), are considered promising materials to be combined with copper for composite foil fabrication. However, the use of GNPs in liquid-phase processes remains challenging due to their hydrophobicity; thus, tailoring their wettability is a subject of rising ... |
41658188 | Temporally Controlled Supramolecular Catalysts with pH-Dependent Activity. | Controlling the activity of synthetic catalysts over time remains a key challenge for designing adaptive chemical systems. Supramolecular phosphodiesterase mimics can be particularly sensitive to pH, with some of them presenting active species that operate only under basic conditions. In this work, we have focused on a... |
41658152 | Supramolecular PDDA/PEDOT:PSS Biosensor for Early Pancreatic Cancer Detection via CA19-9: Clinical Validation on Human Blood Samples. | Pancreatic cancer has one of the highest mortality rates, and early detection remains a challenge, significantly limiting therapeutic strategies. In this study, we present the clinical validation of a novel multilayered capacitance-based biosensor for early pancreatic cancer detection. Poly-(diallyldimethylammonium chl... |
41658137 | Optimizing SSMMP-Based Fillers with -NH<sub>2</sub> Functionalization and PIM‑1 Coating for High-Performance CO<sub>2</sub>/CH<sub>4</sub> and CO<sub>2</sub>/N<sub>2</sub> Separation in Mixed Matrix Membranes and Thin-Film Composite (TFC) Membrane. | Gas separation employing polymeric membranes is limited by the permeability-selectivity trade-off, which has driven the development, among numerous technologies, of mixed matrix membranes (MMMs) that combine highly permeable polymers with fillers capable of enhancing gas selectivity. The compatibility in the filler/pol... |
41658126 | Inhalable Chitosan Microparticles: A Spray-Drying Approach for Enhanced Pulmonary Delivery of Rifampicin. | The study aimed to produce spray-dried microparticles with a higher payload of rifampicin and a suitable size range for targeted drug delivery to alveolar macrophages. The microparticles were initially optimized with respect to solution feed rate, concentration of chitosan, and addition of surfactant, followed by homog... |
41658098 | New Zinc(II) Coordination Compound with 1,10-Phenanthroline and Maleate: Comprehensive Structural Analysis, Periodic-DFT Calculations, and Evaluation of Biological Potential. | The escalating crisis of bacterial resistance necessitates the development of novel antimicrobial agents. Herein, we report the synthesis and comprehensive characterization of a new zinc-(II) coordination compound, [Zn-(phen)-(maleate)-(H<sub>2</sub>O)]·H<sub>2</sub>O (phen = 1,10-phenanthroline). Single-crystal X-ray ... |
41658085 | Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives. | Three-dimensional (3D) metal-organic frameworks (MOFs), are known by various names, such as organic zeolite analogues, 3D porous coordination polymers, hybrid organic-inorganic materials, coordination polymers, and metal-organic polymers, are advanced three-dimensional materials distinguished by their high surface area... |
41658076 | Self-Standing NiFe MOF@Ni<sub>3</sub>S<sub>2</sub> Core-Shell Hierarchical Heterostructure for Enhanced Oxygen Evolution Activity. | Metal-organic frameworks (MOFs) have received widespread attention in various energy related applications due to their unique structural characteristics. Nevertheless, the inherent low electronic conductivity of MOFs is a major limitation for their competitive activity. Herein, we synthesized a self-standing NiFe MOF@N... |
41657995 | Harnessing secondary metabolites of endophytic microbes: a next-generation biopesticide for crop disease management. | This review highlights the potential of endophytic microorganisms and their secondary metabolites as innovative biopesticides for sustainable disease management in agriculture. Agriculture faces substantial challenges from phytopathogens, resulting in significant economic losses worldwide, which are typically addressed... |
41657898 | Unraveling the mechanism of mulberry leaf in alleviating hyperuricemia: key role of kaempferol by modulating AKT pathway and gut-kidney axis. | <h4>Background</h4>Mulberry leaf (<i>Morus alba L</i>.) is an edible plant that has been found to have medicinal effects in the treatment of hyperuricemia (HUA). The bioactive compounds of mulberry leaf and their mechanisms of action have not been determined yet.<h4>Methods</h4><i>In-silico</i> methodologies were used ... |
41657901 | Shotgun metagenomics reveals the prevalence and mobility of antibiotic resistance genes in the West Bay of the human-impacted Laguna Lake. | Laguna Lake, the largest freshwater lake in the Philippines, has been reported to harbor antibiotic-resistant bacteria, posing health risks to the millions who depend on it. However, limited knowledge of antibiotic resistance genes (ARGs) in the lake highlights the need for a comprehensive assessment of its resistome. ... |
41657780 | Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches. | <h4>Background</h4>Hematologic malignancies, including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM), are characterized by high relapse rates due to intrinsic and acquired drug resistance. Resistance mechanisms often involve dysregulation of apop... |
41657779 | Natural products targeting the MAPK signaling pathway: potential options for ulcerative colitis treatment. | As a chronic, recurrent inflammatory bowel disease, ulcerative colitis (UC) poses significant clinical challenges due to its progressive intestinal mucosal damage, recurrent exacerbations of abdominal pain and diarrhea, and increased risk of colorectal cancer conversion with disease duration. Conventional medications s... |
41657772 | Natural compounds in ovarian cancer: mechanistic insights and therapeutic potential. | Ovarian cancer is one of the most lethal gynecologic malignancies due to its late diagnosis, high recurrence rate, and chemoresistance. Recently, increasing evidence has emphasized the therapeutic potentials of natural compounds as multi-targeted agents in modulating key oncogenic pathways and improving standard therap... |
41640463 | PEGylated gold nanoparticles regulate metabolic flux in erythrocytes by inducing hemoglobin deoxygenation. | Nanomedicines based on polyethylene glycol-functionalized gold nanoparticles (Au@PEG NPs) are usually administered by intravenous injection to improve bioavailability. It is widely accepted that surface modification with PEG can prevent direct interactions between AuNPs and proteins. Therefore, the interaction of Au@PE... |
41625491 | Applications of micro/nano drug delivery systems in cancer pain management. | Cancer pain, a critical complication associated with advanced malignant tumors, significantly diminishes patients' quality of life and complicates therapeutic management due to its multifactorial pathophysiology. Current clinical analgesics often face limitations such as tolerance, addiction, and dose-dependent systemi... |
41624985 | Advances in engineering and applications of synthetic phase-separated membraneless organelles in biotechnology. | Membraneless organelles (MLOs) formed through liquid-liquid phase separation (LLPS) constitute crucial dynamic microenvironments within cells, capable of selectively concentrating specific molecules and regulating biochemical reactions. Based on the working mechanisms of natural MLOs, researchers have designed and cons... |
41623522 | Recent developments in the delivery of peptide nucleic acids (PNAs). | Peptide nucleic acid (PNA) oligomers have tremendous potential as therapeutics; however, their delivery is challenging and has limited their development as therapeutics. In recent years, new strategies for delivering water-soluble backbone-modified PNA oligomers into cells for antisense and gene-editing applications ha... |
41619671 | Artemisia argyi essential oil - loaded β-cyclodextrin/whey protein microcapsules: dual antifungal and disease resistance-inducing effects to enhance blueberry shelf life. | To reduce reliance on chemical fungicides, this study developed microencapsulated Artemisia argyi essential oil (AAEO) in β-cyclodextrin/whey protein microcapsules (AAEO-M) as a natural antifungal preservative for blueberries. AAEO-M exhibited high encapsulation efficiency (94.28%) and loading capacity (20.43%), with p... |
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