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41616735 | Cavity acidification limits ferritin iron biomineralization. | Studies of ferritin biomineralization have elucidated iron loading/egress pathways and mechanisms of iron oxidation, while paying less attention to the spatiotemporal details of proton generation during iron hydrolysis. Here, we performed ferroxidase reactions with Archaeoglobus fulgidus ferritin (AfFtn) 24mer cage, wh... |
41616398 | Transmembrane proteome analysis of frozen mouse lung tissues by LC-MS using metal organic framework-based protein extraction. | Membrane proteins (MPs) play crucial roles in cellular functions and are key targets for drug discovery and cancer research. However, due to their poor solubility, high hydrophobicity, and low abundance, MPs present significant analytical challenges, particularly with regard to their dissolution, isolation, and charact... |
41614951 | Natural Phytochemicals as Inhibitors of HIF-1α in Breast Cancer: Review of Preclinical Evidence and Future Prospects. | Breast cancer is the most prevalent form of cancer among women globally. The hypoxic microenvironment resulting from the rapid oxygen consumption of rapidly dividing cancer cells causes the accumulation of hypoxia-inducible factor-1α (HIF-1α) due to reduced catalytic activity of prolyl hydroxylase domain 2 (PHD2) and V... |
41613971 | Toward functional and structurally complex Frank-Kasper phases <i>via</i> creating concavities on supramolecular micelles. | In supramolecular chemistry, higher structural complexity enables emergent functions in ordered soft matter. To construct structurally complex and functional Frank-Kasper (FK) phases, heterogeneity in supramolecular micelles is introduced by blending rigid aromatic dendrons (Ar<sub>2</sub>) with flexible aliphatic dend... |
41613969 | Conformational switching modulates excited-state pathways in a cofacial perylene dimer. | Controlling excited-state pathways in supramolecular chromophore assemblies is key to designing next-generation optoelectronic and photonic materials. Here we elucidate the conformation-dependent photophysics of a flexible perylene diimide (PDI) dimer, valPDI<sub>2</sub>, which undergoes reversible solvent-driven switc... |
41613966 | Superstructure-induced enhancement of solid-state triphenylacrylonitrile photochromism <i>via</i> a macrocycle-mediated blocking strategy. | Developing materials with precisely tunable photochromic properties is crucial for innovative applications, and this requires rational design strategies to overcome photoisomerization constraints imposed by molecular stacking. Herein, we introduce a pillararene-based "blocker" strategy to mitigate π-π stacking of photo... |
41602551 | In Silico Identification of Potential Biomarker-Binding Proteins for Noninvasive Diagnosis of Buruli Ulcer Disease. | Buruli ulcer (BU) is a necrotizing skin disease caused by <i>Mycobacterium ulcerans</i> that produces a virulent lipid toxin, mycolactone, which is detectable in urine. Current diagnostics are time-consuming and require specialized expertise, often leading to delayed diagnosis. This makes it difficult to understand the... |
41602549 | Biomaterials-based engineering of the bone microenvironment for osteoporosis therapy. | Osteoporosis is a progressive skeletal disorder marked by an imbalance between bone resorption and formation, resulting in compromised microarchitecture and increased fracture risk. However, conventional pharmacological therapies have systemic side effects and limited targeting efficiency. Therefore, these limitations ... |
41599969 | Microbiota-Derived Metabolites Associated with Oats and Bran Attenuate Inflammation and Oxidative Stress via the Keap1-Nrf2 Pathway in Zebrafish. | <h4>Background/objectives</h4>Oats and oat bran are rich in polyphenols and soluble fiber, which are metabolized by gut microbiota into bioactive compounds. Previous studies identified ursodeoxycholic acid (UDCA), 3-(3-hydroxyphenyl)propionic acid (3-HPP), and avenanthramide C (AVC) as key microbial metabolites with pr... |
41599596 | Biobased Polymers in Printed Electronics: From Renewable Resources to Functional Devices. | Printed electronics (PE) have emerged as a rapidly growing technology owing to their potential for low-cost fabrication, flexibility, and scalable device manufacturing. The dependence on fossil-based components raises environmental concerns, leading the scientific community toward sustainable solutions, aiming to reduc... |
41599592 | Low-Odor High-Density Fiberboard Enabled by Supramolecular Interactions in Wood Fibers. | The development of sustainable wood-based composites has driven increasing interest in formaldehyde-free, low-odor, and recyclable bonding systems. However, achieving high mechanical performance and dimensional stability in high-density fiberboards (HDFs) without synthetic adhesives remains a challenge. Here, we report... |
41599593 | Linear Polyethyleneimine-Coated Gold Nanoparticles as a Platform for Central Nervous System Targeting. | The unique physicochemical properties of gold nanoparticles (GNPs) have made them versatile tools for biomedical applications, such as imaging, therapy, and drug delivery. The surface modification of GNPs with polymers or biomolecules can enhance their colloidal stability and facilitate internalization into cells. Howe... |
41599595 | Waterborne Poly(urethane-urea)s for Lithium-Ion/Lithium-Metal Batteries. | Waterborne polyurethane (WPU) and waterborne poly(urethane-urea) (WPUU) dispersions allow safer and more sustainable manufacturing of rechargeable batteries via water-based processing, while offering tunable adhesion and segmented-domain mechanics. Beyond conventional roles as binders and coatings, WPU/WPUU chemistries... |
41599432 | Combined Neutron and X-Ray Diffraction Study of Ibuprofen and Atenolol Adsorption in Zeolite Y. | The widespread occurrence of pharmaceutical residues in aquatic environments necessitates the development of advanced porous materials for efficient remediation. This study investigates the adsorption mechanisms of ibuprofen and atenolol within the high-silica zeolite Y. Batch adsorption experiments demonstrated signif... |
41599433 | Computational Analysis of the Asymmetric Hydrogenation of γ-Ketoacids: Weak Interactions and Kinetics. | A computational study of the mechanism of asymmetric hydrogenation of γ-keto acids with the Ni(S,S)-QuinoxP* system was conducted. The main steps of the reaction mechanism were determined, including the formation of the NiH(S,S-QuinoxP*)<sup>+</sup> complex starting from a γ-keto acid molecule and the involvement of th... |
41599244 | New Properties of Supramolecular Complexes and Drug Nanoparticles. | Supramolecular chemistry-is "the chemistry beyond the molecule bearing on the organized entities of higher complexity that result from the association of two or more chemical species held together by intermolecular forces"-J [...]. |
41597281 | The Taurine-Slc6a6 Axis Promotes Breast Cancer Progression by Alleviating Oxidative Stress and Accelerating Cell Cycle Progression. | Taurine metabolism is emerging as an important player in cancer progression, yet its precise roles remain incompletely understood. Our study revealed that elevated serum Taurine levels and concomitant upregulation of its transporter, Slc6a6, are associated with enhanced tumor growth. Functionally, Slc6a6 overexpression... |
41596998 | Current Progress and Future Directions of Enzyme Technology in Food Nutrition: A Comprehensive Review of Processing, Nutrition, and Functional Innovation. | Enzyme technology, characterized by high efficiency, environmental compatibility, and precise controllability, has become a pivotal biocatalytic approach for quality enhancement and nutritional improvement in modern food industries. This review summarizes recent advances and underlying mechanisms of enzyme applications... |
41596996 | AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative <i>In Silico</i> and Experimental Strategy. | To enhance the screening efficiency of bioactive peptides, an AI-driven approach was employed to screen DPP-IV inhibitory peptides from goat blood proteins by an integrated <i>in silico</i>, <i>in vitro</i>, and machine learning strategy. Furthermore, the inhibitory mechanism of DPP-IV inhibitory peptides was elucidate... |
41596769 | Discovery and Preliminary Characterization of Lactose-Transforming Enzymes in <i>Ewingella americana</i> L47: A Genomic, Biochemical, and In Silico Approach. | D-tagatose is a high-value, low-calorie sweetener that can be produced from dairy lactose via a two-step enzymatic route: lactose hydrolysis to galactose followed by galactose isomerization to tagatose. Here, we combined genomics, in silico structural analysis, and biochemical assays to evaluate the lactose-to-tagatose... |
41596767 | Hybrid Dual-Context Prompted Cross-Attention Framework with Language Model Guidance for Multi-Label Prediction of Human Off-Target Ligand-Protein Interactions. | Accurately identifying drug off-targets is essential for reducing toxicity and improving the success rate of pharmaceutical discovery pipelines. However, current deep learning approaches often struggle to fuse chemical structure, protein biology, and multi-target context. Here, we introduce HDPC-LGT (Hybrid Dual-Prompt... |
41596764 | BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting. | The BCL-2 family of proteins plays a central role in the regulation of apoptosis, with BCL-2 and BCL-xL representing two of its most prominent antiapoptotic members. This review explores the molecular regulation of BCL-2 and BCL-xL genes, emphasizing the structural domains that define the functions of the broader BCL-2... |
41596759 | UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment. | Mitophagy, as a critical form of selective autophagy, plays a central role in maintaining cellular homeostasis. While the canonical PTEN-Induced Kinase 1 (PINK1)-Parkin pathway is well established, mitophagy can still be effectively induced in Parkin-deficient cells such as HeLa, indicating the existence of Parkin-inde... |
41596732 | Synthesis of Folic Acid-Functionalized Hybrid Mesoporous Silica Nanoparticles and In Vitro Evaluation on MCF-7 Breast Cancer Cells. | Folate receptor alpha is expressed at low levels in normal tissues, but is elevated in aggressive breast cancer types and can be utilized for targeted nanoparticle delivery. Hence, we prepared a hybrid nanocarrier based on in-house synthesized mesoporous silica nanoparticles (MSNs) which were further lipid-coated and r... |
41596200 | The Mechanism of Oxidative Stress in Pulmonary Fibrosis and Research Progress. | Pulmonary fibrosis (PF) is a group of chronic progressive lung diseases characterized by irreversible remodeling of lung tissue structure, abnormal proliferation of fibroblasts, and excessive deposition of extracellular matrix (ECM), among which idiopathic pulmonary fibrosis (IPF) is the most typical subtype. Currently... |
41594941 | Suppressing Endothelial-Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study. | <h4>Background</h4>Myocardial fibrosis, a central pathological process leading to heart failure, lacks specific mechanism-based therapies. Although the anti-inflammatory activity of the natural compound protocatechuic acid is recognized, its direct anti-fibrotic mechanism, particularly concerning the critical role of e... |
41594938 | Durable Management of Plant Viruses: Insights into Host Resistance and Tolerance Mechanisms. | Plant viruses cause substantial yield and quality losses worldwide, and their rapid evolution can erode deployed host resistance. This review synthesizes current knowledge of antiviral resistance and tolerance mechanisms, using barley yellow dwarf virus (BYDV) in cereals as an illustrative case study. We first summariz... |
41591202 | Strategies for Removal of Protein-Bound Uremic Toxins in Hemodialysis. | The removal of protein-bound uremic toxins (PBUTs) from the blood of kidney failure patients with conventional dialysis is limited. However, as their harmful effects and association with morbidity and mortality in dialysis patients are increasingly recognized, PBUTs have become important therapeutic targets. In this re... |
41591065 | Preparation Method of Upconversion Nanoparticles and Its Biological Application. | Next-generation therapeutic devices will rely on an intelligent integrated system that consolidates multiple functions into a single platform. These individual chemical components exhibit diverse physicochemical properties, demonstrating multifunctional characteristics. In this review, we focus on how the distinctive p... |
41590492 | Morphology and Comparative Transcriptome Analysis of Resistant and Susceptible Bitter Gourd (<i>Momordica charantia</i> L.) Reveals the Molecular Response Related to Powdery Mildew Resistance. | Powdery mildew (PM) is a major disease affecting bitter gourd cultivation, and resolving the molecular regulatory mechanisms underlying PM resistance is important for bitter gourd molecular breeding for resistance. In this study, morphological and molecular methods were used to identify the PM pathogen in bitter gourd,... |
41588942 | Advancements in 3D Printing and Nanomaterials for Personalized Drug Delivery. | 3D printing, also known as additive manufacturing, has transformed drug delivery by enabling the development of complex, patient-specific dosage forms and implantable systems tailored to individual therapeutic needs. This review explores the convergence of 3D printing technologies with nanomaterials in the fabrication ... |
41587515 | Construction of BSA-CuNCs@UiO-66 nanoprobe based on MOF confinement effect and its ultrasensitive fluorescence sensing for creatinine. | This study employed a pore-confined synthesis strategy to achieve the in situ growth of bovine serum albumin-capped copper nanoclusters (BSA-CuNCs) within the UiO-66 framework (BSA-CuNCs@UiO-66). This nanocomposite enables highly sensitive and specific detection of creatinine (CR). Results demonstrated that the spatial... |
41584447 | Cucurbit[7]uril as a universal anchor for photoswitchable monolayers on gold. | Photoresponsive self-assembled monolayers (SAMs) were fabricated on gold surfaces using cucurbit[7]uril (CB[7])-based host-guest complexes. In this architecture, the macrocyclic CB[7] unit serves as a universal anchoring platform, with one portal binding to the gold surface and the opposite portal encapsulating a photo... |
41584134 | A Grignard-mediated route to access 4-substituted-3-<i>E</i>-styryl-2<i>H</i>-chromenes: alternate extrinsic FRET probes to explore the IIA and IIIA subdomains of serum proteins. | A facile and efficient strategy to construct 2<i>H</i>-chromene scaffolds, employing variably substituted spiro-4-oxochroman-3,1'-cyclopropane precursors under mild conditions, is proposed in this study. The transformation proceeds <i>via</i> a ring-opening reaction of cyclopropane mediated by Grignard reagents and fur... |
41584126 | Emerging composite electrode architectures based on transition metal oxides for high-performance Li-ion capacitors. | Lithium-ion capacitors (LICs) have emerged as next-generation electrochemical energy storage systems by effectively bridging the long-standing performance gap between lithium-ion batteries and supercapacitors (SCs), offering a rare combination of high energy density, high power density, and ultralong cycle life. Despit... |
41584113 | Recent advancement in ZnAl-LDH-mediated systems towards photocatalytic energy and environmental applications and piezo polarized photocatalytic reactions: synthesis to application <i>via</i> mechanistic insights. | ZnAl-layered double hydroxide (ZnAl-LDH) is an emerging robust material that has attracted great attention in the field of photocatalysis and piezo polarization-induced photocatalysis owing to its unique physicochemical properties, including a high specific surface area, tunability in metal cation dispersion, specific ... |
41584111 | MnFe aminoclay as a novel catalyst: structural characterization and potential for catechol detection. | The development of enzyme-mimicking nanomaterials offers a promising route toward sensitive, stable, and cost-effective detection of phenolic compounds. In this study, MnFe hybrid aminoclay (MnFeAC) was synthesized and systematically characterized by XRD, XPS, SEM, TEM, and elemental mapping to confirm its amorphous st... |
41583905 | Genomic-Based Epidemiological Analysis of the Post-Pandemic <i>Mycoplasma pneumoniae</i> Resurgence. | <i>Mycoplasma pneumoniae</i> infections resurged globally in 2023-2024 following a significant decline during the coronavirus disease 2019 (COVID-19) pandemic. To understand the genomic epidemiology of this resurgence in China, a nationwide 1-year genomic surveillance identified 9907 patients infected with <i>M. pneumo... |
41583391 | Spatiotemporal Regulation of Ligand Trafficking and TLR9 Activation by PIEZO1 in Human Plasmacytoid Dendritic Cells. | Plasmacytoid dendritic cells (pDCs) are innate immune cells that produce type I interferons (IFNs) upon sensing nucleic acids via Toll-like receptor 9 (TLR9). Synthetic oligodeoxynucleotides CpGA and CpGB are widely used TLR9 agonists, yet only CpGA robustly induces IFN-α in pDCs. In contrast, CpGB drives much less IFN... |
41584110 | Hollow zinc phthalocyanine nanoshells: quick low temperature synthesis, enhanced near-IR absorption and water-dispersibility for photocatalysis and phototherapy. | A quick (two minutes), low temperature (10 °C) synthesis has been developed to obtain crystalline and hollow zinc phthalocyanine (ZnPc) nanoshells (major axis: 32.0 ± 5.2 nm, aspect ratio: 1.3, void size: 18.1 ± 2.3 nm) with a redshift of the Q-band and emergence of a new NIR peak (746 nm). Thioglycolic acid (TGA)-capp... |
41580257 | Bio-piezoelectric β-glycine/gelatin composite films fabricated via synergistic molecular self-assembly and thermally assisted evaporation-induced crystallization. | Developing bio-piezoelectric materials that simultaneously provide high piezoelectric output and superior mechanical flexibility remains challenging, largely due to difficulties in achieving self-alignment and barriers to scalable synthesis. This study introduces a bio-piezoelectric composite film simply composed of β-... |
41580126 | A supramolecular peptide reprograms PD-L1<sup>+</sup> tumor-associated macrophages to enhance antitumor immunity in lung adenocarcinoma. | Despite advances in immune checkpoint inhibitors (ICIs), clinical benefit in lung adenocarcinoma (LUAD) remains limited, largely due to a highly immunosuppressive tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs), particularly the PD-L1-positive subset (PD-L1<sup>+</sup> TAMs), are key mediators... |
41580080 | Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope. | Bacteriocins are toxins deployed by bacteria to kill their competitors. Here, I reflect on my laboratory's work on protein bacteriocins and their immunity proteins from Gram-negative bacteria. We uncovered the structural and biophysical principles that underpin the 10-log stability range of protective immunity proteins... |
41579991 | Recent advances in polysaccharide-based strategies for glaucoma therapy: A review. | Glaucoma remains one of the leading causes of visual impairment and blindness worldwide. Recent investigations have highlighted four major therapeutic targets in glaucoma treatment: intraocular pressure elevation, oxidative stress, inflammation, and neurodegeneration. In this context, polysaccharides have emerged as pr... |
41579918 | Reverse micelles produce hydroxyapatite nanoparticles as more efficient gene delivery carriers than regular micelles. | Hydroxyapatite (HAp) is an effective inorganic gene delivery carrier due to its ability to transport genetic cargo across cell membranes, protect it from proteolysis, and enable escape from late endosomes via pH-controlled dissolution. However, its transfection efficiency remains lower than that of viral agents, prompt... |
41576953 | Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic. | The 2018-2020 Ebola virus disease (EVD) epidemic facilitated the emergence of viral mutations, enhancing the potential for host adaptation during sustained human transmission. Here, we identified the Ebola virus (EBOV) glycoprotein V75A (GP-V75A) substitution as a dominant variant during the epidemic. This substitution... |
41576943 | Pipe dream to pipeline: Journey of cancer vaccines and the road ahead. | Over the past decade, clinical trials of therapeutic cancer vaccines have evolved substantially in scope and design, renewing interest in this immunotherapy modality. Advances in sequencing technologies and an improved understanding of the tumor microenvironment have enabled precise targeting of tumor neoantigens, acce... |
41572932 | LysM receptor-like kinase MdLYK3 destabilizes the ABA receptors PYR/PYLs to suppress ABA signaling in apple. | ABA signaling is a central regulator of plant responses to abiotic stress. Similarly, LysM receptor-like kinases (LYKs) are well-established for their role in biotic stress responses. However, a potential function for LYKs in abiotic stress adaptation and their crosstalk with the ABA pathway remains largely unexplored.... |
41572741 | Nanoliposomal juglone/β-cyclodextrin complex as a biocontrol strategy against plant pathogenic bacteria. | Tomatoes are susceptible to a variety of pathogens, including bacteria, which can significantly impact plant yield and quality. The application of natural antibacterial agents, such as juglone, has shown promise in the biocontrol of these pathogens. The main objective of this study was to investigate the effects of lip... |
41572596 | B-N Coordination-Triggered LE-State Enhancement: A Blue-Shifted Ratiometric Fluorescent Probe for Reversible Detection of MPEA Vapor. | Methamphetamine (MA), a highly potent synthetic illicit drug, poses grave threats to the global public health and societal stability. However, on-site fluorescence detection to MA (particularly those operating in the visible range─remain scarce). In this work, a boron-based ratiometric fluorescent probe, <b>BA-</b><i><... |
41572578 | Precision Channel Engineering of Nanotube-Embedded Organic Electrochemical Transistors for Ultrasensitive Neurofilament Light Chain Detection. | The quantitative monitoring of neurofilament light chain (Nf-L) is critical for the early diagnosis and prognosis of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), yet achieving femtomolar sensitivity in a portable, label-free format remains a formidable challenge. Here, we report a high-perf... |
41572521 | Simultaneously Achieving Efficient Narrow-Band Emission and Large Emission Dissymmetry Factor in an Achiral Hybrid Indium Chloride. | To achieve high contrast in three-dimensional display, circularly polarized luminescence (CPL) materials should simultaneously have narrow full width at half-maximum (FWHM), high photoluminescence quantum yield (PLQY), and large dissymmetry factor (g<sub>lum</sub>). However, very few materials can fulfill it. Herein, w... |
41572506 | Improving the Skin-Conformability of Wearable Continuous Glucose Monitors With Synthetic Hydrogel Electrodes. | Synthetic bioelectronics is rapidly advancing, propelled by breakthroughs in synthetic biology and bioelectronics. This convergence is key to next-generation wearable and implantable devices, enabling seamless integration with living systems. Here, we introduce an enzymatic hydrogel electrode (GelZymes) developed via a... |
41572469 | Interfacial Modification of Nanochannels for Enhanced Detection Accuracy in Complex Matrices. | Solid-state nanochannels, as an emerging single-molecule sensing platform, have shown great potential in environmental monitoring, biomedical diagnostics, and food safety owing to their high stability, tunable geometry, and facile surface functionalization. However, in complex matrices, nonspecific adsorption, ion comp... |
41572431 | Interfacial Engineering in Rare-Earth Oxide/ZnO Heterojunctions for High-Performance Trimethylamine Sensing and Fish Freshness Monitoring. | Developing high-performance gas sensors for room-temperature (RT) operation remains a significant challenge in the field of gas detection. This study addresses this issue by designing and synthesizing a series of rare-earth (RE) oxide modified ZnO heterojunctions (RE<sub>2</sub>O<sub>3</sub>/ZnO, RE = Nd, Y, Yb) via a ... |
41572261 | Dose-dependent antiviral effects of glycyrrhizin, curcumin, and harmaline against clinical SARS-CoV-2 isolates, including D614G, Omicron BA.5, and Omicron XBB.1. | <h4>Background</h4>SARS-CoV-2 remains a major global health challenge, as infection can lead to potential life-threatening conditions such as COVID-19. Emerging variants of the virus are characterized by higher transmission rates and immune escape mutations, enabling them to evade vaccine-induced immunity. Existing tre... |
41572135 | A Nonpillar Shaped Pillararene Derivative, Oxgens2 Pillar[6]arene: Synthesis, Structure, and Iodine Adsorption. | A nonpillar shaped Pillararene derivative, Oxgens2 pillar[6]arene, has been synthesized via [4 + 2] and [2 + 1+2 + 1] cyclization reactions from an oxygen substituted dimer and an oxygen substituted tetramer, respectively. X-ray crystallographic studies reveal that the introduction of oxygen atoms renders O2 pillar[6]a... |
41571794 | Supramolecular aggregation of aquaporin-4 shapes astrocyte collective migration and mechanics. | Aquaporin-4 (AQP4), the main astrocytic water channel, assembles into supramolecular structures known as Orthogonal Arrays of Particles (OAPs). While AQP4-mediated water fluxes are known to influence cytoskeletal dynamics at the single-cell level, their role in collective migration remain unclear. Using primary WT and ... |
41571690 | A bacterial defense system targeting modified cytosine of phage genomic DNA. | The evolutionary arms race between bacteria and phages drives the development of bacterial antiviral defense systems and phage counter-defense strategies. Restriction-modification (RM) systems protect bacteria by methylating 'self' DNA and cleaving unmodified phage DNA. Phages like T-even coliphages evade RM systems by... |
41571677 | Asymmetrical covalent organic framework mixed matrix membranes for highly efficient gas separation. | The asymmetrical and seamless Covalent organic framework (COF)-mixed matrix membranes (COF-MMMs) extending over the centimeter scale for highly efficient H<sub>2</sub>/CO<sub>2</sub> separation are fabricated via a non-solvent induced phase separation (NIPS)-triggered in situ interfacial polymerization (IP) strategy. H... |
41571658 | Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa. | The transition between motility-associated acute infection and biofilm-associated chronic infection is crucial for bacterial proliferation and survival within hosts. This process of transition can be influenced by various host and environmental cues, however, whether bacteria could actively modulate the switch remains ... |
41571665 | Reversible bismuth reduction-driven dark photoelectrochemistry. | Current research in photoelectrochemical (PEC) systems focuses on designing photoelectrodes with light-enhanced charge transfer efficiency at the solid-liquid interface, which leads to the oxidation of various reductant molecules at the anode, posing a challenge in terms of selectivity. In this study, we introduce an o... |
41571571 | Toward next-generation therapeutic HPV vaccines: A review on expanding the antigen repertoire and an integrated bioinformatics selection framework. | For successful clinical translation of therapeutic human papillomavirus (HPV) vaccines, optimizing antigen selection is key to enhancing efficacy. Traditional E6/E7 targets are limited by heterogeneous tumor expression. This review advocates expanding the antigen repertoire to include tumor-specific neoantigens in next... |
41571273 | Bilirubin-Albumin Nanoparticle-Encapsulated Hydrogels for the Treatment of Pelvic Organ Prolapse. | Pelvic organ prolapse (POP) is characterized by the displacement or even protrusion of the uterus and adnexal tissues into or through the vaginal orifice, severely compromising the physical and mental well-being of the patients. Current treatment methods, including surgery and mechanical restoration, are associated wit... |
41570294 | In Situ Enzymatic Generation of Metal-Organic Frameworks for Target-Gated Electrochemiluminescence Detection of miRNA. | Metal-organic frameworks (MOFs) hold great promise in electrochemiluminescence (ECL) biosensing; however, their applications are severely restricted by a cumbersome preparation procedure and low emission efficiency. In order to address these challenges, we developed a novel MOF-based ECL biosensor via an in situ genera... |
41570251 | Supramolecular Encapsulation of [Nd(NO<sub>3</sub>)<sub>6</sub>]<sup>3-</sup> by <i>dpat</i> Retained in Acetonitrile. | Understanding how outer-sphere interactions influence the inner-sphere structure of lanthanide complexes in solution is crucial for advancing applications in separations, materials, and nuclear chemistry. Here, we investigate the solution-phase coordination environment of Nd(NO<sub>3</sub>)<sub>3</sub> in acetonitrile ... |
41570113 | Deconstructing and Rationalizing Interpenetration in Pillar-Layered Metal-Organic Frameworks. | Structural interpenetration, a prevalent phenomenon in crystalline networks assembled from molecular building blocks, exerts a profound impact on the stability, porosity, flexibility, and functionality of the materials. However, the rational design and construction of crystalline architectures with tailorable interpene... |
41570062 | Engineered Supramolecular Therapeutics in Development for Combating Antibiotic-Resistant Bacterial Infections. | The emergence of antibiotic-resistant bacteria has rendered conventional antibiotic treatments ineffective, necessitating the development of antibacterial agents with unique mechanisms of action. To address this challenge, researchers have increasingly resorted to synthetic and bioengineered nanomaterials to augment th... |
41570052 | Bayesian data driven modelling of kinetochore dynamics: Space-time organisation of the human metaphase plate. | Mitosis is a complex self-organising process that achieves high fidelity separation of duplicated chromosomes into two daughter cells through capture and alignment of chromosomes to the spindle mid-plane. Chromosome movements are driven by kinetochores (KTs), multi-protein machines that attach chromosomes to microtubul... |
41569891 | Transition Metal Compounds for Aqueous Ammonium-Ion Batteries: Storage Mechanisms and Electrode Design. | Aqueous ammonium-ion batteries (AAIBs) have recently emerged as promising candidates for next-generation energy storage owing to their intrinsic safety, environmental benignity, and cost efficiency. The unique tetrahedral configuration and hydrogen-bonding capability of NH<sub>4</sub> <sup>+</sup> enable fast ion trans... |
41569811 | Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly. | Phosphate esters and anhydrides are central to biology, storing and transferring chemical energy to sustain processes from metabolism to translation. Among them, acyl phosphates are highly reactive, yet biology channels their activation chemistry almost exclusively through aminoacyl adenylates. This conserved design le... |
41569787 | An In Operando Probe of CO<sub>2</sub> Diffusion by Microfluidic Spectroelectrochemistry. | CO<sub>2</sub> diffusion is the rate-determining step for electrochemical CO<sub>2</sub> reduction at large current densities. Herein, we develop a microfluidic spectroelectrochemical approach to measure the diffusion coefficients of CO<sub>2</sub> in bicarbonates in operando for the first time. Our results establish t... |
41569643 | Enhancing Water Stability and Cathode Photocurrent of CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> Perovskite via Bidentate Ligand-Bridged Covalent Passivation for PEC-EC Dual-Mode Assay of PTP1B Activity. | Cathodic photoelectrochemical (PEC) sensing has attracted significant attention due to its remarkable anti-interference capability but is severely limited by the lack of high-performance photocathodic materials. Recently, CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> (MAPbI<sub>3</sub>) perovskite demonstrated a large ca... |
41569525 | Lipids regulate epidermal growth factor receptor activation by its ligands. | The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that has garnered extensive interest since its discovery as an oncogene product in the 1980s. We now understand that the binding of soluble growth factors to EGFR activates it by facilitating receptor-mediated EGFR dimerization. However, how the ... |
41569018 | Aromatic Cation-π Interaction-Driven Scalable Biomimetic Pockets Embedded Supramolecular Coassemblies for Controllable CO and CH<sub>4</sub> Selectivity in CO<sub>2</sub> Photoreduction. | Rationally engineering a photocatalyst to deliver high, controllable selectivity in CO<sub>2</sub> reduction (CO<sub>2</sub>RR) is crucial for addressing global energy challenges. However, in organic supramolecular systems, this control is difficult due to the lack of well-defined coordination sites to stabilize interm... |
41569000 | Symmetry-Regulated Argentophilic Interactions via Homochiral Proline Dodecamers. | Although the argentophilic interaction has been reported in the ligand-supported interactions in crystal engineering, the controllable chemical flexibility of such an interaction, which can alter the properties of corresponding materials in response to changes, is very lacking. To fulfill such a task, providing a flexi... |
41568982 | Vibrational-State-Regulated Hot-Band Thermal Activation for Anti-Stokes Luminescence. | Thermal-vibrational-activation-dominated hot-band absorption (HBA) is a key mechanism for achieving anti-Stokes luminescence, utilizing environmental thermal energy to enable photon emission at energies higher than absorption. The HBA necessitates thermal vibrational activation (υ = 0 → 1), which remains a challenging ... |
41568902 | A Smart-Perception Rare Earth MOF. | Smart responsive luminescent materials have attracted considerable scientific and technological interest owing to their broad optoelectronic applications. However, issues such as single responsive mode, inadequate spectral coverage, and poor environmental adaptability still hinder their diversified development. Herein,... |
41568874 | Decoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange. | The design of hydrogels that combine mechanical robustness with dynamic reconfigurability remains a fundamental challenge, as increasing crosslink dissociation rates compromise network integrity. This limitation is addressed through the incorporation of an associative crosslink exchange into DNA-based supramolecular hy... |
41568870 | An In Situ Embedded B-MOF Sponge With Shape-Memory for All-in-One Diabetic Wound Therapy. | Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and susceptibility to infection, posing significant clinical challenges. Here, we report an intelligent shape-memory sponge (P<sub>1</sub>A<sub>3</sub>@B-MOF) engineered for the programmable modulation of the diabetic wound microenviro... |
41568788 | Structure-Activity Relationships of Cyclodextrin-Included Quercetin and Naringenin and the Protective Effect of the Inclusion Complexes against UVB-Induced Photodamage. | Quercetin (Que) and naringenin (Nar) are natural compounds with potent antioxidant and anti-inflammatory activities, showing promise for alleviating ultraviolet B (UVB)-induced skin photoaging. The presence or absence of a C═C bond in the C-ring defines whether the compound is a flavonol or a flavanone. To overcome poo... |
41568656 | Charge-Transfer-Driven Enantioselective Surface-Enhanced Raman Scattering on a ZIF-8/ZnS Heterojunction: A Chiral-Label-Free Biosensor for Quantification of Urinary Lactate Enantiomeric Excess. | Abnormal lactic acid (LA) enantiomeric excess (ee) in biofluids is closely associated with various intestinal diseases. Here, we report a chiral-label-free nonplasmonic surface-enhanced Raman scattering (SERS) platform using a ZIF-8/ZnS heterojunction that enables direct quantification of LA enantiomers and their ee va... |
41568649 | Hydrogelation via Supramolecular Copolymerization of Structural Water within Adaptive Metal-Organic Fibers. | Water is conventionally viewed as a disruptive solvent for supramolecular materials, destabilizing directional noncovalent interactions. Here, we report a metal-organic material in which water instead acts as a structural co-monomer driving the formation of supramolecular fibers. A zinc(II) bisphenoxyimine ("Salphen") ... |
41568623 | Unveiling Dexter-Type Triplet-Triplet Energy Transfer of Homologue Room-Temperature Phosphorescence in Host-Guest Doped Systems. | Intermolecular energy transfer plays an important role in organic-doped room-temperature phosphorescence (RTP). However, it is difficult to precisely design high-performance RTP by organic-doped systems unless the insight into luminescence is clear. Here, the luminescent mechanism using benzophenone (BP) as host and BP... |
41567080 | Cold Crystallization of a Macrocyclic Molecule with Semiflexible Silyl Ether Units. | Cold crystallization, an exothermic phase transition upon heating of a glassy state, is of interest in heat storage materials. While such behavior is common in polymers, small-molecule systems have also been investigated. Herein, we report a semiflexible macrocyclic compound composed of four silyl ether units and aroma... |
41565711 | Vectorial noncovalent synthesis of bendable organic crystals through dynamic dislocation. | Organic molecular crystals with controllable bending angles are crucial interconnectors in integrated optoelectronic chips, which can precisely guide optical signals along a predetermined path to achieve effective optical path steering. Nevertheless, current methods of tailoring molecular crystals with desired bent geo... |
41529294 | Enhancing the microwave absorption capability of metal-organic frameworks through the incorporation of polypyrrole nanoparticles. | Metal-organic frameworks (MOFs) have emerged as promising microwave absorbers owing to their tunable composition, structural diversity, and high porosity. However, their low intrinsic permittivity leads to impedance mismatch and inadequate attenuation capacity. To address this limitation, we developed a series of polyp... |
41511803 | Zn-MOF-8-based nitrogen-doped mesoporous carbon/multi-walled carbon nanotube-modified electrodes for highly sensitive detection of isoquercitrin. | In this study, nitrogen-doped mesoporous carbon (NMC) was synthesized using Zn-MOF-8 as a template, followed by further reaction with multi-walled carbon nanotubes (MWCNTs) to prepare the NMC/MWCNTs nanocomposite. Characterization of the composite was performed using scanning electron microscopy (SEM), energy dispersiv... |
41511506 | Analytical applications of gas-phase ion chemistry enabled by mass spectrometry. | Analytical mass spectrometry (MS) has been employed to study a wide variety of analytes, including metabolites, lipids, pharmaceutical compounds, pesticides, petroleum, peptides, proteins, protein complexes, nucleic acids, and glycans. The field of gas-phase ion chemistry in mass spectrometry studies the impacts of the... |
41432281 | Sequence-independent optical regulation of CRISPR/Cas editing using star-shaped crRNA dendrimers. | Precise spatiotemporal control of CRISPR/Cas editing is vital for studying dynamic processes and ensuring therapeutic safety. We present a single-site photolabile crRNA dendrimer platform enabling robust, sequence-independent optical regulation of Cas9 and Cas12a. This simple, universal strategy achieves rapid OFF-to-O... |
41431987 | Fluorescence sensor based on molecularly imprinted polymers and upconversion micro-particles@metal-organic frameworks for detection of fipronil. | Fipronil is a broad-spectrum insecticide that is widely applied in agriculture, household, and public health applications. However, its abuse can lead to environmental pollution and endanger human health. Therefore, it is important to develop a simple and low-cost method for detecting fipronil. In this study, a novel f... |
41416988 | Cryo-optical setup for wide-field microscopy and spectroscopy of luminescent nanomaterials. | Studying photoluminescence (PL) is essential for understanding and engineering light-emitting nanomaterials. Heterogeneous samples, such as thin films and microstructures, require characterization of the spatial distribution of PL intensity, spectra, lifetimes, and photon correlations at the microscale under variable t... |
41416950 | Polymeric-protein-MOF nanoparticles with stimuli-responsive disassembly and highly reproducible synthesis. | Metal-organic frameworks (MOFs), such as zeolitic imidazolate framework-8 (ZIF-8), offer a promising platform for therapeutic protein delivery due to their biocompatibility and tunable degradation properties. However, the clinical translation of protein-loaded MOFs has been limited by poor colloidal stability and a lac... |
41416869 | Efficient photocatalytic conversion of CO<sub>2</sub> to acetic acid using a composite catalyst. | Transforming CO<sub>2</sub> into high-value chemicals is crucial for combating the rising threats of global warming and energy-related problems. The selective generation of C2 or C2+ products <i>via</i> CO<sub>2</sub> photoreduction is a complex endeavor, largely hindered by the sluggish kinetics of C-C bond formation.... |
41400476 | Role of weak and transient interactions in the polymer-free electrospinning of β-cyclodextrin derivatives. | Polymer-free electrospinning enables the fabrication of nanofibers from low-molecular-weight compounds without polymeric additives, where intermolecular interactions or molecular aggregates substitute for polymer chain entanglements. Cyclodextrins (CDs) are among the most widely studied examples, yet the electrospinnin... |
41395972 | Supramolecular light-harvesting systems enabled by amphiphiles. | Organizing photoactive components into well-defined nanostructures is a powerful strategy to enhance light harvesting and energy transfer efficiency. Amphiphiles have emerged as unique molecular tools to achieve such organization directly in aqueous media, offering both structural precision and environmental compatibil... |
41924452 | Manganese Biomineralized Ferritin Nanoplatforms with Shielding and Stimuli-Responsive Release for Potentiated Ferroptosis and Multimodal Ovarian Cancer Therapy. | <h4>Purpose</h4>Natural ferritin Fn) is a cage-like protein with a central cavity, making it a promising vehicle for drug delivery. However, its non-specific accumulation in iron-metabolizing organs impairs targeting precision and therapeutic efficacy. To overcome this challenge, we aimed to develop a novel biomimetic ... |
41869401 | Advances in the Prevention and Treatment of Radiation Skin Injury: Mechanisms, Pharmacological Interventions, and Applications of Novel Dressings. | Radiation skin injury (RSI) is a common complication during tumor radiotherapy, significantly impacting patients' quality of life and treatment outcomes. In recent years, with the rapid development of biomedical material technologies, the application of novel dressings in the prevention and treatment of RSI has made re... |
41868188 | Formulation and Physicochemical Characterization of Capecitabine-Loaded Cubosomes for Enhanced Drug Delivery System. | <h4>Background</h4>Capecitabine (CPB) is a hydrophilic anticancer drug classified as Biopharmaceutics Classification System (BCS) Class III, which presents challenges for effective dermal delivery. Objectives: This study aimed to develop and characterize a topical cubosomal formulation encapsulating CPB to enhance its ... |
41831952 | β-Cyclodextrin-functionalized Zr-sulfonamide MOF novel pH-responsive nano platform for breast and lung cancer. | Despite significant advancements in cancer therapies, lung and breast cancers continue to pose serious challenges, remaining among the most prevalent and lethal forms of the disease. This study investigates an innovative approach to enhance drug delivery and treatment efficacy through the synthesis of sulfonamide UiO-M... |
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