title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
|---|---|---|---|---|---|---|---|
Oxidative capacity and ageing in human muscle. | This study determined the decline in oxidative capacity per volume of human vastus lateralis muscle between nine adult (mean age 38.8 years) and 40 elderly (mean age 68.8 years) human subjects (age range 25-80 years). We based our oxidative capacity estimates on the kinetics of changes in creatine phosphate content ([P... | 10.1111/j.1469-7793.2000.t01-1-00203.x | 10,878,112 | D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002851:Chromatography, High Pressure Liquid; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D0... | The Journal of physiology | 2,000 | D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate |
Effect of accelerated autolysis of yeast on the composition and foaming properties of sparkling wines elaborated by a champenoise method. | Five mutants (obtained by UV mutagenesis) and the parent strain were selected to produce sparkling wines following the traditional or champenoise method. The wines were aged with the yeast for 9 months, with samples being taken each month for analytical and sensory determinations. The wines elaborated with mutant strai... | 10.1021/jf050191v | 16,131,135 | D002253:Carbonated Beverages; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D005511:Food Handling; D006801:Humans; D009154:Mutation; D011134:Polysaccharides; D012441:Saccharomyces cerevisiae; D012677:Sensation; D013997:Time Factors; D014920:Wine | Journal of agricultural and food chemistry | 2,005 | D011134:Polysaccharides |
Repeatability analysis of the Tetrahymena pyriformis population growth impairment assay. | Assessments necessary to ensure the safety of both humans and the environment are challenged by the sheer number of chemicals in use today. Chemical legislation, such as REACH, aims to use alternative methods to reduce the reliance on in vivo animal testing. Consequently, databases such as the TETRATOX database, contai... | 10.1080/1062936X.2011.604100 | 21,830,879 | D003198:Computer Simulation; D019992:Databases as Topic; D004785:Environmental Pollutants; D021281:Quantitative Structure-Activity Relationship; D015203:Reproducibility of Results; D013769:Tetrahymena pyriformis; D018675:Toxicity Tests | SAR and QSAR in environmental research | 2,011 | D004785:Environmental Pollutants |
[Clinical significance of NADPH-dependent dehydrogenases in lymphocytes from patients with bronchial asthma]. | The activities of lymphocyte NADP-dependent dehydrogenases were evaluated in 84 children with atopic asthma during relapses and clinical remission. The pattern and severity of changes in the studied enzymes depended on children's age and duration and severity of disease. Changes in the older age group and during relaps... | 11,582,669 | D001249:Asthma; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008163:Luminescent Measurements; D008214:Lymphocytes; D009252:NADPH Dehydrogenase | Klinicheskaia laboratornaia diagnostika | 2,001 | D009252:NADPH Dehydrogenase | |
Estimation of clinical axial extension of Class II caries lesions with ultraspeed and digital radiographs: an in-vivo study. | This study compared the newly introduced direct digital radiographic (DDR) system (RVG-6000) with conventional bitewing radiographs (D-speed film) to estimate the extension of Class II caries lesions. The patient's discomfort related to placement of each radiographic packet was also evaluated. Fifty-one Class II caries... | 10.2341/07-167 | 19,051,853 | D000328:Adult; D003731:Dental Caries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D019252:Radiography, Dental, Digital; D011862:Radiography, Panoramic; D011795:Surveys and Questionnaires; D014962:X-Ray Film; D055815:Young Adult | Operative dentistry | 2,008 | |
Lispro analog for treatment of generalized allergy to human insulin. | OBJECTIVE
To evaluate the clinical usefulness of the human insulin analog lispro in a patient with generalized allergy to human insulin.
RESEARCH DESIGN AND METHODS
A 34-year-old obese female patient developed systemic allergic reactions to human insulin but tolerated insulin lispro. Sequential analyses of the anti-i... | 10.2337/diacare.20.9.1357 | 9,283,778 | D000328:Adult; D000818:Animals; D003429:Cross Reactions; D003888:Desensitization, Immunologic; D003924:Diabetes Mellitus, Type 2; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007328:Insulin; D007330:Insulin Antibodies; D... | Diabetes care | 1,997 | D007004:Hypoglycemic Agents; D007074:Immunoglobulin G; D007328:Insulin; D007330:Insulin Antibodies; D061268:Insulin Lispro; D007457:Iodine Radioisotopes; D007073:Immunoglobulin E |
Assessing the Impact of Telemedicine Implementation in Diverse Health Care Systems. | Health care organizations and systems can have a large impact on how extensively telemedicine and virtual visits are used by medical practices and individual clinicians. This supplemental issue of medical care aims to advance evidence about how health care organizations and systems can best support telemedicine and vir... | 10.1097/MLR.0000000000001820 | 36,893,412 | D000368:Aged; D014481:United States; D000328:Adult; D006801:Humans; D058873:Pandemics; D000086382:COVID-19; D006278:Medicare; D017216:Telemedicine; D003151:Community Health Centers | Medical care | 2,023 | |
Effect of topography on the risk of malaria infection in the Usambara Mountains, Tanzania. | We investigated whether the risk of infection with malaria parasites was related to topography in the Usambara Mountains, Tanzania. Clinical surveys were carried out in seven villages, situated at altitudes from 300 m to 1650 m. Each village was mapped and incorporated into a Digital Terrain Model. Univariate analysis ... | 10.1016/j.trstmh.2003.11.005 | 15,138,076 | D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000531:Altitude; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D012111:R... | Transactions of the Royal Society of Tropical Medicine and Hygiene | 2,004 | |
[Study of thyroid function using diverse methods of separation of plasma radioiodine compounds in rats]. | We compared the fractionations obtained by three different methods of dosage of thyroid hormones and we concluded that trichloracetic PBI is very rapid, (about 15 minutes) excluding the length of calculation of radio activity), is easy to execute, and uses inexpensive materials. Separation by exchanging resins of ions ... | 80,920 | D000818:Animals; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D005260:Female; D051381:Rats; D013960:Thyroid Function Tests; D013963:Thyroid Hormones; D014238:Trichloroacetic Acid | Acta medica Iranica | 1,976 | D013963:Thyroid Hormones; D014238:Trichloroacetic Acid | |
Linkage disequilibrium and the genetic distance in livestock populations: the impact of inbreeding. | Genome-wide linkage disequilibrium (LD) is subject to intensive investigation in human and livestock populations since it can potentially reveal aspects of a population history, permit to date them and help in fine-gene mapping. The most commonly used measure of LD between multiallelic loci is the coefficient D'. Data ... | 10.1186/1297-9686-36-3-281 | 15,107,267 | D000483:Alleles; D000818:Animals; D000829:Animals, Domestic; D003433:Crosses, Genetic; D005260:Female; D005828:Genetics, Population; D007178:Inbreeding; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D008957:Models, Genetic | Genetics, selection, evolution : GSE | 2,004 | |
Traumatic diaphragmatic injuries in infants and children: imaging findings. | OBJECTIVES
Traumatic diaphragmatic injuries (DI) in infants and children are uncommon and are often associated with multiple severe injuries. Delayed presentation can be life threatening due to organ herniation and strangulation. We present the imaging findings in a relatively large population of children who experienc... | 10.1007/s002470000242 | 10,929,366 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging; D003964:Diaphragm; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012421:Rupture; D014947:Wounds and Injuries | Pediatric radiology | 2,000 | |
Solar Hydrocarbons: Single-Step, Atmospheric-Pressure Synthesis of C2 -C4 Alkanes and Alkenes from CO2. | Cobalt ferrite (CoFe2 O4 ) spinel has been found to produce C2 -C4 hydrocarbons in a single-step, ambient-pressure, photocatalytic hydrogenation of CO2 with a rate of 1.1 mmol g-1 h-1 , selectivity of 29.8 % and conversion yield of 12.9 %. On stream the CoFe2 O4 reconstructs to a CoFe-CoFe2 O4 alloy-spinel nanocomposi... | 10.1002/anie.202304470 | 37,137,871 | Angewandte Chemie (International ed. in English) | 2,023 | ||
UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer. | UQCRFS1 has been reported to be highly expressed in gastric and breast cancer, but the mechanism remains unclear. The prognosis and biological functions of UQCRFS1 in ovarian cancer (OC) have not been evaluated. The expression of UQCRFS1 in EOC was detected by GEPIA and HPA websites, and the prognosis value was investi... | 10.1038/s41598-023-35572-z | 37,221,238 | D006801:Humans; D005260:Female; D010051:Ovarian Neoplasms; D011379:Prognosis; D045744:Cell Line, Tumor; D017382:Reactive Oxygen Species; D015415:Biomarkers; D007506:Iron-Sulfur Proteins | Scientific reports | 2,023 | D017382:Reactive Oxygen Species; D015415:Biomarkers; C579514:UQCRFS1 protein, human; D007506:Iron-Sulfur Proteins |
Structural brain abnormalities in unselected in-patients with major depression. | OBJECTIVE
Several studies have indicated an increased frequency of cerebral atrophy and white matter lesions in patients with major depression, especially in older age groups.
METHOD
Forty-four representative in-patients with major depression in which neurological disorders were clinically excluded, and 49 age- and g... | 10.1034/j.1600-0447.2001.00305.x | 11,328,242 | D000328:Adult; D001921:Brain; D002560:Cerebrovascular Circulation; D003865:Depressive Disorder, Major; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severit... | Acta psychiatrica Scandinavica | 2,001 | |
Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1. | Resistance to multiple anticancer agents is a major obstacle in the successful treatment of cancers. Overexpression of some ATP-binding cassette (ABC) membrane transporters such as ABCC1 has been shown to be a major contributor of multidrug resistance (MDR) in both laboratory cell line models and the clinical setting. ... | 10.1021/bi101350x | 21,090,806 | D000595:Amino Acid Sequence; D002460:Cell Line; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008969:Molecular Sequence Data; D027425:Multidrug Resistance-Associated Proteins; D009154:Mutation; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D021122:Protein Subunits | Biochemistry | 2,010 | D027425:Multidrug Resistance-Associated Proteins; D021122:Protein Subunits; C421109:multidrug resistance-associated protein 1 |
An emergent self-organizing map based analysis pipeline for comparative metabolome studies. | Modern high-throughput techniques allow for the identification and quantification of hundreds of metabolites ofa biological system which cover central parts of the metabolome. Due to the amount and complexity of obtained data there is an increasing need for the development of appropriate computational interpretation me... | 20,109,147 | D002851:Chromatography, High Pressure Liquid; D016000:Cluster Analysis; D048230:Corynebacterium glutamicum; D003627:Data Interpretation, Statistical; D057166:High-Throughput Screening Assays; D008433:Mathematics; D055442:Metabolome; D055432:Metabolomics; D025341:Principal Component Analysis; D012984:Software; D053719:T... | In silico biology | 2,009 | ||
Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers. | Autophagy is an intracellular degradation/recycling pathway that provides nutrients and building blocks to cellular metabolism and keeps the cytoplasm clear of obsolete proteins and organelles. During recent years, dysregulated autophagy activity has been reported to be a characteristic of many different disease types,... | 10.1016/j.bioorg.2019.03.021 | 30,884,310 | D001343:Autophagy; D000071183:Autophagy-Related Proteins; D003546:Cysteine Endopeptidases; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014334:Tropolone | Bioorganic chemistry | 2,019 | D000071183:Autophagy-Related Proteins; D004791:Enzyme Inhibitors; D014334:Tropolone; C507524:ATG4B protein, human; D003546:Cysteine Endopeptidases |
Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit. | BACKGROUND
Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective treatments.
AIM
To assess the clinical characteristics, diagnosis, and treatment of malignant changes secondary to PJS.
METHODS
The clinical data of five patients with mali... | 10.12998/wjcc.v8.i2.264 | 32,047,774 | World journal of clinical cases | 2,020 | ||
Clinical picture of orf in Northern California. | Eighteen cases of orf are reported, six with multiple lesions and twelve with only one. Iridoform bullae were seen in every case, and untraumatized lesions healed without scar. The fingers and hands were involved in fourteen instances, the remainder occurring on the forearms, nose, forehead, and eyelid. Lack of systemi... | 560,287 | D000818:Animals; D003937:Diagnosis, Differential; D004474:Ecthyma, Contagious; D006801:Humans; D011213:Poxviridae Infections; D012756:Sheep | Cutis | 1,977 | ||
Dietary aluminum and Alzheimer's disease--a review. | Current evidence suggests that dietary aluminum is neither an essential nutrient nor a toxic element causing neurological damage. The phosphate and fluoride salts of aluminum are very insoluble. When fed in excess, aluminum increases the dietary needs for these anions. Aluminum hydroxide is used as an antacid that can ... | 10.1016/0048-9697(81)90105-4 | 7,010,599 | D000535:Aluminum; D000544:Alzheimer Disease; D000818:Animals; D001927:Brain Diseases; D003704:Dementia; D004032:Diet; D006801:Humans; D006435:Renal Dialysis; D014511:Uremia | The Science of the total environment | 1,981 | D000535:Aluminum |
Impact of SBAR on Nurse Shift Reports and Staff Rounding. | The Situation-Background-Assessment-Recommendation (SBAR) protocol was used to improve shift reports and interdisciplinary rounding. On a medical-surgical unit, observations were conducted before and after implementation. Both processes were significantly shorter and more consistent. SBAR enabled more focused and effic... | 26,292,447 | D003266:Continuity of Patient Care; D006801:Humans; D007318:Inservice Training; D033183:Interdisciplinary Communication; D009741:Nursing Staff, Hospital; D062209:Patient Handoff; D010819:Physician's Role; D015397:Program Evaluation; D056164:Teaching Rounds | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | 2,014 | ||
Influenza virus-specific cytotoxic T cells in man; induction and properties of the cytotoxic cell. | Human peripheral blood lymphocytes have been sensitized in vitro to influenza virus antigen. After an induction period of 4--14 days, cytotoxic cells which lyse autologous influenza virus-infected lymphoid cells could be demonstrated. The cytotoxic cell is a T lymphocyte which shows specificity for sensitizing influenz... | 10.1002/eji.1830081007 | 309,394 | D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006801:Humans; D009980:Influenza A virus; D007700:Kinetics; D012621:Seasons; D013601:T-Lymphocytes | European journal of immunology | 1,978 | |
Congenital nasal cerebrospinal fluid fistula. | A management protocol for congenital nasal cerebrospinal fluid fistulas is proposed based on our successful experience with a twice recurrent fistula: 1. Careful preoperative observation of the skin dimple for fluid leakage. 2. Transnasal radiographic contrast study. 3. Synchronous transnasal-transcranial excision of t... | 10.1097/00006534-198206000-00017 | 7,079,407 | D000015:Abnormalities, Multiple; D002559:Cerebrospinal Fluid Rhinorrhea; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008588:Meningocele; D008722:Methods | Plastic and reconstructive surgery | 1,982 | |
Determinants of intention to get vaccinated against novel (pandemic) influenza A H1N1 among health-care workers in a nationwide survey. | A nationwide survey was conducted in October-November 2009 to investigate determinants of intention to get vaccinated against novel (pandemic) influenza A H1N1 among health-care workers (HCWs) in Greece. Out of 12,879 participating HCWs (response rate: 12.1%) working in 152 (40%) of 380 health-care facilities in Greece... | 10.1016/j.jinf.2010.06.004 | 20,600,304 | D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006282:Health Personnel; D006801:Humans; D017053:Infection Control; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines; D007251:Influenza, Human; D033182:Intention; D008297:Male; D037141:Mandatory Programs; D032541:Mass Vaccination; D008875:... | The Journal of infection | 2,010 | D007252:Influenza Vaccines |
Prenatal substance abuse: short- and long-term effects on the exposed fetus. | Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician's role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition of medical issues for the exposed newborn ... | 10.1542/peds.2012-3931 | 23,439,891 | D005260:Female; D047109:Fetal Development; D006801:Humans; D013287:Illicit Drugs; D007231:Infant, Newborn; D009357:Neonatal Abstinence Syndrome; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D058028:Research Report; D019966:Substance-Related Disorders; D013997:Time Factors | Pediatrics | 2,013 | D013287:Illicit Drugs |
A spatial oculomotor memory-task performance produces a task-related slow shift in human electroencephalography. | Electroencephalographic (EEG) deflections in humans related to the performance of memory-guided saccades were studied in this work. The EEG deflections were recorded during 2 spatial oculomotor delayed response tasks in which the subject was instructed to make a saccade either to the right or to the left depending on t... | 10.1016/0013-4694(94)00289-w | 7,774,523 | D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography; D004585:Electrooculography; D005074:Evoked Potentials, Visual; D005260:Female; D007839:Functional Laterality; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008568:Memory; D009801:Oculomotor Muscles; D012438:Saccades; D013647:Tas... | Electroencephalography and clinical neurophysiology | 1,995 | |
Sheath-Core Graphite/Silk Fiber Made by Dry-Meyer-Rod-Coating for Wearable Strain Sensors. | Recent years have witnessed the explosive development of flexible strain sensors. Nanomaterials have been widely utilized to fabricate flexible strain sensors, because of their high flexibility and electrical conductivity. However, the fabrication processes for nanomaterials and the subsequent strain sensors are genera... | 10.1021/acsami.6b06984 | 27,462,991 | ACS applied materials & interfaces | 2,016 | ||
Glaucoma: an overview. | Glaucoma is one of the leading causes of blindness. It is a public health problem. No race is exempted from getting glaucoma. In the United States there are more than 2 million people afflicted with this disease. Every effort should be made to detect those people at risk early, and adequately manage them to prevent bli... | 8,715,021 | D001766:Blindness; D005901:Glaucoma; D006801:Humans; D012106:Research | Journal of ophthalmic nursing & technology | 1,996 | ||
A common origin of the 4143insA ADAMTS13 mutation. | Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease, ADAMTS13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP.... | 10.1160/TH05-12-0817 | 16,807,643 | D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005060:Europe; D005192:Family Health; D005260:Female; D018703:Founder Effect; D016368:Frameshift Mutation; D006239:Haplotypes; D006801:Humans; D008297:Male; D... | Thrombosis and haemostasis | 2,006 | D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human |
Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. | The intent of this contribution is to provide an update of the progress we have made towards developing a method/treatment to permanently sterilize cats. Our approach employs two complementary methodologies: RNA interference (RNAi) to silence genes involved in the central control of reproduction and a virus-based gene ... | 10.1111/rda.12834 | 27,859,771 | D000818:Animals; D002415:Cats; D003267:Contraception; D000229:Dependovirus; D015870:Gene Expression; D020868:Gene Silencing; D005818:Genetic Engineering; D005822:Genetic Vectors; D007031:Hypothalamus; D007246:Infertility; D059648:Kisspeptins; D015287:Neurokinin B; D034622:RNA Interference | Reproduction in domestic animals = Zuchthygiene | 2,017 | D059648:Kisspeptins; D015287:Neurokinin B |
Down regulation of G protein-coupled receptor 137 expression inhibits proliferation and promotes apoptosis in leukemia cells. | BACKGROUND
G protein-coupled receptors (GPR) are involved in a wide range of physiological processes, some of which, however, can be hijacked by tumor cells. Over-expression of G protein-coupled receptors 137 (GPR137) are associated with the growth of tumor cells, but under-expression of GPR137 has shown to inhibit cel... | 10.1186/s12935-018-0507-1 | 29,422,775 | Cancer cell international | 2,018 | ||
The Blood-Cerebrospinal Fluid Barrier Is Selective for Red Cabbage Anthocyanins and Their Metabolites. | The study aim was to determine whether strongly bioactive hydrophilic red cabbage anthocyanins possess the ability to cross the blood-cerebrospinal fluid barrier (blood-CSF barrier) and whether there is a selectivity of this barrier toward these compounds. To fulfill objectives, red cabbage preparation, containing nona... | 10.1021/acs.jafc.0c03170 | 32,640,787 | D000821:Animal Feed; D000818:Animals; D000872:Anthocyanins; D001812:Blood-Brain Barrier; D001937:Brassica; D002555:Cerebrospinal Fluid; D002851:Chromatography, High Pressure Liquid; D012756:Sheep; D014556:Urine | Journal of agricultural and food chemistry | 2,020 | D000872:Anthocyanins |
Ethylene Sensor-Enabled Dynamic Monitoring and Multi-Strategies Control for Quality Management of Fruit Cold Chain Logistics. | Due to the presence of bioactive compounds, fruits are an essential part of people's healthy diet. However, endogenous ethylene produced by climacteric fruits and exogenous ethylene in the microenvironment could play a pivotal role in the physiological and metabolic activities, leading to quality losses during storage ... | 10.3390/s20205830 | 33,076,361 | Sensors (Basel, Switzerland) | 2,020 | ||
Plasma cell leukemia: response to conventional myeloma therapy. | A 76-year-old man with plasma cell leukemia was treated with L-phenylalanine mustard and prednisone (CLGB 7461). There was good partial remission of the plasma cell disease characterized by disappearance of the plasma cells in the peripheral blood, reduction of plasma cells in the marrow aspirates to less than 5% of th... | 272,434 | D000368:Aged; D006801:Humans; D007952:Leukemia, Plasma Cell; D008297:Male; D008558:Melphalan; D009101:Multiple Myeloma; D011241:Prednisone | Journal of medicine | 1,977 | D008558:Melphalan; D011241:Prednisone | |
Transmission of spike trains at the retinogeniculate synapse. | Retinal spikes impinging on relay neurons in the lateral geniculate nucleus (LGN) generate synaptic potentials, which sometimes produce spikes sent to visual cortex. We examined how signal transmission is regulated in the macaque LGN by recording the retinal input to a single LGN neuron while stimulating the receptive ... | 10.1523/JNEUROSCI.5077-06.2007 | 17,344,406 | D000200:Action Potentials; D000818:Animals; D019706:Excitatory Postsynaptic Potentials; D005829:Geniculate Bodies; D008253:Macaca mulatta; D009474:Neurons; D010775:Photic Stimulation; D011930:Reaction Time; D012160:Retina; D012165:Retinal Ganglion Cells; D009435:Synaptic Transmission | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,007 | |
Graphical representation of neuromuscular function in spinal cord injury. | Accurate determination of the location and extent of a spinal cord leson is essential to the ongoing therapeutic plans for a patient as well as for overall program evaluation in a spinal cord center. The interpretation of muscle function tests performed for this purpose is often complex due to the large number of muscl... | 1,267,589 | D000328:Adult; D003201:Computers; D006225:Hand; D006801:Humans; D008297:Male; D009132:Muscles; D009460:Neurologic Examination; D013119:Spinal Cord Injuries | Archives of physical medicine and rehabilitation | 1,976 | ||
Association of consciousness impairment and mortality in people with COVID-19. | BACKGROUND
To investigate the association between impairment of consciousness and risk of death in people with COVID-19.
METHODS
In this multicentre retrospective study, we enrolled people with confirmed COVID-19 from 44 hospitals in Wuhan and Sichuan, China, between 18 January and 30 March 2020. We extracted demogra... | 10.1111/ane.13471 | 34,028,792 | D000086382:COVID-19; D003243:Consciousness; D018450:Disease Progression; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000086402:SARS-CoV-2; D013997:Time Factors | Acta neurologica Scandinavica | 2,021 | |
Exon identity influences splicing induced by exonic variants and in silico prediction efficacy. | BACKGROUND
Minigenes and in silico prediction tools are commonly used to assess the impact on splicing of CFTR variants. Exon skipping is often neglected though it could impact the efficacy of targeted therapies. The aim of the study was to identify exon skipping associated with CFTR variants and to evaluate in silico ... | 10.1016/j.jcf.2020.12.003 | 33,341,408 | D017398:Alternative Splicing; D002478:Cells, Cultured; D003550:Cystic Fibrosis; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D005091:Exons; D006801:Humans; D009297:Nasal Mucosa; D022821:RNA Splice Sites; D017384:Sequence Deletion | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society | 2,021 | D022821:RNA Splice Sites; D019005:Cystic Fibrosis Transmembrane Conductance Regulator |
Integrated concentration of growth hormone in juvenile-onset diabetes. | Twenty-four-hour patterns of plasma growth hormone concentrations were evaluated during 50 studies of 42 subjects with juvenile-onset diabetes mellitus. Blood was sampled continuously over 24 h using a portable peristaltic pump under conditions in which subjects remained ambulatory and maintained their daily dietary an... | 10.2337/diab.29.5.391 | 6,991,330 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001786:Blood Glucose; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1; D005260:Female; D013006:Growth Hormone; D006801:Humans; D006943:Hyperglycemia; D007328:Insulin; D008019:Life Style; D008297:Male; D012737:Sex Factors; D013997:Time Factors | Diabetes | 1,980 | D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone |
Shoulder strapping for stroke-related upper limb dysfunction and shoulder impairments: systematic review. | BACKGROUND
Shoulder impairments are common after stroke, resulting in reduced upper limb function. Shoulder strapping may be beneficial as an adjunct to conventional therapy and warrants further investigation.
OBJECTIVES
To determine i) the efficacy and ii) any adverse effects of shoulder strapping used to reduce str... | 10.3233/NRE-141108 | 24,990,036 | D006801:Humans; D009069:Movement Disorders; D010243:Paralysis; D011596:Psychomotor Disorders; D020127:Recovery of Function; D012149:Restraint, Physical; D012782:Shoulder; D020521:Stroke; D000071939:Stroke Rehabilitation | NeuroRehabilitation | 2,014 | |
The transition from water-breathing to air-breathing is associated with a shift in ion uptake from gills to gut: a study of two closely related erythrinid teleosts, Hoplerythrinus unitaeniatus and Hoplias malabaricus. | The evolutionary transition from water-breathing to air-breathing involved not only a change in function of the organs of respiratory gas exchange and N-waste excretion, but also in the organs of ion uptake from the environment. A combination of in vivo and in vitro techniques was used to look at the relative importanc... | 10.1007/s00360-016-0965-5 | 26,857,274 | D000388:Air; D000818:Animals; D060125:Characiformes; D002712:Chlorides; D005880:Gills; D000860:Hypoxia; D007408:Intestinal Absorption; D007413:Intestinal Mucosa; D007422:Intestines; D007477:Ions; D011188:Potassium; D012143:Respiratory Physiological Phenomena; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; ... | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology | 2,016 | D002712:Chlorides; D007477:Ions; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium |
[Merkel cell carcinoma and sentinel lymph node dissection: nine cases report]. | Merkel cell carcinoma (MCC) is an aggressive cutaneous-neuroendocrine neoplasia with poor prognosis and high propensity for locoregional and distant metastasis. Lack of knowledge about its biological behavior, pathogenesis, and prognostic factors, complicates the prospective evaluation. Sentinel node dissection, concom... | 18,252,145 | D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D0... | Il Giornale di chirurgia | 2,008 | ||
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB. | The crystal structure of the unphosphorylated state of methylesterase CheB shows that the regulatory domain blocks access of substrate to the active site of the catalytic domain. Phosphorylation of CheB at Asp56 results in a catalytically active transiently phosphorylated enzyme with a lifetime of approximately two sec... | 10.1006/jmbi.2001.4523 | 11,286,548 | D000577:Amides; D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D001665:Binding Sites; D002265:Carboxylic Ester Hydrolases; D020134:Catalytic Domain; D006859:Hydrogen; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D020836:Protein Structure, Quaternary; D017434:Protein Str... | Journal of molecular biology | 2,001 | D000577:Amides; D001426:Bacterial Proteins; D012997:Solvents; D006859:Hydrogen; D002265:Carboxylic Ester Hydrolases; C041144:chemotactic protein methylesterase |
A trinuclear cobalt-based coordination polymer as an efficient oxygen evolution electrocatalyst at neutral pH. | The dearth of an efficient, robust, abundant and cost-effective water oxidation catalyst is debatably the major hurdle for the technological advancement of artificial photosynthesis devices. Herein, a three dimensional (3D) cobalt-based coordination polymer {[Co3(pyz)(fa)3(dmso)2]·2H2O}n, (1) (pyz = pyrazine, fa = fuma... | 10.1016/j.jcis.2019.03.018 | 30,897,422 | Journal of colloid and interface science | 2,019 | ||
Maintenance of ribosomal protein S19 in plasma by complex formation with prothrombin. | We have demonstrated that the cross-linking of ribosomal protein S19 (RP S19) on platelets by activated factor XIII provides chemotactic potency to monocytes/macrophages for a resolution of coagulum. Factor XIII is activated by an active form of prothrombin, thrombin. We here report that RP S19 is present as a complex ... | 10.1111/j.1600-0609.2011.01585.x | 21,306,436 | D000595:Amino Acid Sequence; D000925:Anticoagulants; D001665:Binding Sites; D001777:Blood Coagulation; D001792:Blood Platelets; D002118:Calcium; D003432:Cross-Linking Reagents; D005170:Factor X; D026122:Factor XIIIa; D006801:Humans; D066298:In Vitro Techniques; D046912:Multiprotein Complexes; D017434:Protein Structure,... | European journal of haematology | 2,011 | D000925:Anticoagulants; D003432:Cross-Linking Reagents; D046912:Multiprotein Complexes; D012269:Ribosomal Proteins; C040343:ribosomal protein S19; D014859:Warfarin; D011516:Prothrombin; D005170:Factor X; D026122:Factor XIIIa; D002118:Calcium |
A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities. | The phytochemical analysis of the ethyl acetate fraction of Arum palaestinum Boiss. (Araceae) led to the isolation and identification of a new polyhydroxy alkaloid compound; (S)-3,4,5-trihydroxy-1 H-pyrrol-2(5H)-one (1), and other five known compounds; caffeic acid (2), isoorientin (3), luteolin (4) and vicenin 11 (5),... | 10.1007/BF02993958 | 17,879,743 | D000085:Acetates; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D031058:Arum; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular... | Archives of pharmacal research | 2,007 | D000085:Acetates; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D010936:Plant Extracts; D011758:Pyrroles; C007650:ethyl acetate |
Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning. | Accurate specification of the drugs' solubility is known as an important activity to appropriately manage the supercritical impregnation process. Over the last decades, the application of supercritical fluids (SCFs), mainly CO2, has found great interest as a promising solution to dominate the limitations of traditional... | 10.1038/s41598-022-17440-4 | 35,908,085 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D006801:Humans; D000069550:Machine Learning; D000077431:Oxaprozin; D011422:Propionates; D012995:Solubility | Scientific reports | 2,022 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D000077431:Oxaprozin |
Use of a solid absorbent and an accelerant detection canine for the detection of ignitable liquids burned in a structure fire. | Ignitable Liquid Absorbent (ILA), a commercial solid absorbent intended to assist fire scene investigators in sample location and collection, has been field tested in three separate room fires. The ability of the ILA to detect and absorb different amounts of gasoline, odorless paint thinner, and camp fuel on two differ... | 10.1111/j.1556-4029.2007.00408.x | 17,397,503 | D000818:Animals; D004285:Dogs; D005390:Fires; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry; D010578:Petroleum; D012903:Smell | Journal of forensic sciences | 2,007 | D010578:Petroleum |
Traction injury of the brachial plexus confused with nerve injury due to interscalene brachial block: A case report. | INTRODUCTION
Shoulder surgery is often performed with the patient in the so called "beach-chair position" with elevation of the upper part of the body. The anesthetic procedure can be general anesthesia and/or regional block, usually interscalenic brachial plexus block. We present a case of brachial plexus palsy with a... | 10.1016/j.ijscr.2016.08.023 | 27,560,643 | International journal of surgery case reports | 2,016 | ||
Neosphincters in the management of faecal incontinence. | BACKGROUND
Surgical treatment of end-stage faecal incontinence has its origin in the early 1950s. Interest has been revived as a result of technical advances achieved in the recent past. The purpose of this article is to review the principles that underlie the use of skeletal muscle transposition around the anal canal ... | 10.1046/j.1365-2168.2000.01605.x | 11,122,175 | D001003:Anal Canal; D001187:Artificial Organs; D004558:Electric Stimulation; D005242:Fecal Incontinence; D006801:Humans; D009119:Muscle Contraction; D018482:Muscle, Skeletal; D016896:Treatment Outcome | The British journal of surgery | 2,000 | |
Visualization of a protein involved in seric immune complexes of patients with epithelial tumors having elevated levels of anti-'benzo[a]pyrene-like' IgA. | Many authors have previously described that several types of human cancer were associated with elevated levels of IgA and IgA-containing immune complexes. We have recently identified and characterized IgA directed against a "benzo[a]pyrene-like' antigen in sera of patients with mammary tumors. Circulating immune comple... | 10.1016/0304-3835(91)90118-2 | 1,756,513 | D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001564:Benzo(a)pyrene; D014408:Biomarkers, Tumor; D015153:Blotting, Western; D001943:Breast Neoplasms; D002277:Carcinoma; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D00... | Cancer letters | 1,991 | D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D007070:Immunoglobulin A; D001564:Benzo(a)pyrene |
E-Hitz: a word frequency list and a program for deriving psycholinguistic statistics in an agglutinative language (Basque). | We describe a Windows program that enables users to obtain a broad range of statistics concerning the properties of word and nonword stimuli in an agglutinative language (Basque), including measures of word frequency (at the whole-word and lemma levels), bigram and biphone frequency, orthographic similarity, orthograph... | 10.3758/bf03193893 | 17,393,832 | D006801:Humans; D007802:Language; D010507:Periodicity; D010700:Phonetics; D011578:Psycholinguistics; D012984:Software; D014825:Vocabulary | Behavior research methods | 2,006 | |
Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma. | The purpose of this bi-institutional retrospective study was to determine whether survival for dogs with extremity osteosarcoma (OS) is improved through the use of stereotactic radiotherapy (SRT; a single fraction of 25 Gy, or 36 Gy total given in three consecutive daily fractions) plus chemotherapy, vs lower dose conv... | 10.1111/vco.12576 | 32,048,435 | D000818:Animals; D000970:Antineoplastic Agents; D001859:Bone Neoplasms; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D050723:Fractures, Bone; D008175:Lung Neoplasms; D008297:Male; D009657:North Carolina; D012516:Osteosarcoma; D010146:Pain; D011829:Radiation Dosage; D011878:Radiotherapy; D012189:Retrospective Stu... | Veterinary and comparative oncology | 2,020 | D000970:Antineoplastic Agents |
Symptom Endorsement and Sociodemographic Correlates of Postnatal Distress in Three Low Income Countries. | Background. Maternal mental illness has been implicated in adverse child development outcomes. Factors such as context and culture may influence experiences of maternal distress and explain differences in outcomes across settings. Methods. We analyzed baseline data from 5,647 mothers in Ethiopia, India (Andhra Pradesh)... | 10.1155/2016/1823836 | 26,981,278 | Depression research and treatment | 2,016 | ||
Systemic and forearm haemodynamic and metabolic effects of racemic propranolol or D-propranolol in healthy subjects. | 1. The immediate haemodynamic and metabolic effects of intravenous administration of DL-propranolol and D-propranolol were studied in healthy male subjects at rest and during dynamic forearm exercise. The dose of DL-propranolol and of D-propranolol was 0.1 and 1.0 mg/kg body weight respectively. 2. DL-Propranolol reduc... | 10.1042/cs0600675 | 7,249,547 | D000328:Adult; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005542:Forearm; D006439:Hemodynamics; D006801:Humans; D007773:Lactates; D008297:Male; D005082:Physical Exertion; D011433:Propranolol; D012039:Regional Blood Flow; D013237:Stereoisomerism | Clinical science (London, England : 1979) | 1,981 | D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011433:Propranolol |
Acoustic neuroma. | This article reviews the definition of acoustic neuroma, prevalence, growth, symptoms, diagnosis, multiple treatment options, postoperative complications, alternative therapies, and patient and health care provider resources. | 12,029,771 | D006801:Humans; D009464:Neuroma, Acoustic; D011182:Postoperative Care | Seminars in perioperative nursing | 2,000 | ||
Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction. | Osteocytes are considered the primary mechanosensors of bone, but the signaling pathways they apply in mechanotransduction are still incompletely investigated and characterized. A growing body of data strongly indicates that P2 receptor signaling among osteoblasts and osteoclasts has regulatory effects on bone remodeli... | 26,327,582 | D000255:Adenosine Triphosphate; D000818:Animals; D016723:Bone Remodeling; D020013:Calcium Signaling; D002460:Cell Line; D018031:Connexin 43; D017630:Connexins; D015870:Gene Expression; D040542:Mechanotransduction, Cellular; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins; D010011:Osteocytes; D058469:Receptor... | Cellular signalling | 2,015 | D018031:Connexin 43; D017630:Connexins; C543076:GJA1 protein, mouse; D009419:Nerve Tissue Proteins; C503631:Panx1 protein, mouse; D058469:Receptors, Purinergic P2X; D000255:Adenosine Triphosphate | |
Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Phenoxyethanol, Methylparaben, Propylparaben, Mometasone Furoate, and Tazarotene in Topical Pharmaceutical Dosage Formulation. | A stability-indicating RP-HPLC method has been developed and validated for the simultaneous determination of phenoxyethanol (PE), methylparaben (MP), propylparaben (PP), mometasone furoate (MF), and tazarotene (TA) in topical pharmaceutical dosage formulation. The desired chromatographic separation was achieved on the ... | 10.3797/scipharm.1303-22 | 24,482,766 | Scientia pharmaceutica | 2,013 | ||
Depression, anxiety, and psychosocial stressors across BMI classes: A Norwegian population study - The HUNT Study. | Background
Obesity is a global issue with detrimental health impacts. Recent research has highlighted the complexity of obesity due to its psychological correlates. The purpose of the present study was to explore the relationship between body mass index (BMI) and depression, anxiety, and psychosocial stress.
Methods
... | 10.3389/fendo.2022.886148 | 36,034,441 | D000328:Adult; D000368:Aged; D001007:Anxiety; D015992:Body Mass Index; D003863:Depression; D006801:Humans; D009765:Obesity; D050177:Overweight | Frontiers in endocrinology | 2,022 | |
Infectious bursal disease virus replication is inhibited by avain T cell chemoattractant chemokine CCL19. | Chemokine CCL19, together with its receptor CCR7, is one of the most important factors recruiting immune cells into target organ during virus infection. Our previous study has shown that CCL19 played a vital role in the process of T cell trafficking into bursae during bursal disease virus (IBDV) infection. In this stud... | 10.3389/fmicb.2022.912908 | 35,935,208 | Frontiers in microbiology | 2,022 | ||
Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent. | Anti-metastatic activities of IH901, an intestinal bacterial metabolic derivative formed from Ginseng protopanaxadiol saponins, was determinedin vitro andin vivo. Underin vitro conditions, IH901 inhibited the migration of bovine aortic endothelial cells 25 times stronger than suramin and suppressed the invasion of HT10... | 10.1007/BF02975208 | 18,982,256 | Archives of pharmacal research | 1,997 | ||
The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc. | The 2A proteinase (2A(pro)) of human rhinoviruses (HRVs) is a cysteine protease containing a structurally important zinc ion. In the viral polyprotein, the enzyme cleaves between the C terminus of VP1 and its own N terminus. 2A(pro) also processes the two isoforms of the cellular protein, eukaryotic initiation factor 4... | 10.1128/jvi.77.8.5021-5025.2003 | 12,663,811 | D002614:Chelating Agents; D003546:Cysteine Endopeptidases; D005029:Ethylenediamines; D039603:Eukaryotic Initiation Factor-4G; D006367:HeLa Cells; D006801:Humans; D010446:Peptide Fragments; D010448:Peptide Initiation Factors; D011499:Protein Processing, Post-Translational; D012229:Rhinovirus; D014764:Viral Proteins; D01... | Journal of virology | 2,003 | D002614:Chelating Agents; C113920:EIF4G1 protein, human; D005029:Ethylenediamines; D039603:Eukaryotic Initiation Factor-4G; D010446:Peptide Fragments; D010448:Peptide Initiation Factors; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; C057400:picornain 2A, Picornavirus; D015032:Zinc; C044387:N,N,N',N'-tetrakis... |
Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. | We have developed a human brain tumor model in immunodeficient rats that gradually changes its phenotype by serial passages in vivo, from a highly infiltrative, non-angiogenic one with numerous stem cell markers [low-generation (LG) tumor] to a more typical glioblastoma one with extensive angiogenesis and necrosis [hig... | 10.1002/nbm.1263 | 18,613,001 | D000818:Animals; D001932:Brain Neoplasms; D045744:Cell Line, Tumor; D002794:Choline; D005909:Glioblastoma; D018698:Glutamic Acid; D009682:Magnetic Resonance Spectroscopy; D010641:Phenotype; D051381:Rats; D011923:Rats, Nude | NMR in biomedicine | 2,008 | D018698:Glutamic Acid; D002794:Choline |
Structure and dynamics of the lipid modifications of a transmembrane α-helical peptide determined by ²H solid-state NMR spectroscopy. | The fusion of biological membranes is mediated by integral membrane proteins with α-helical transmembrane segments. Additionally, those proteins are often modified by the covalent attachment of hydrocarbon chains. Previously, a series of de novo designed α-helical peptides with mixed Leu/Val sequences was presented, mi... | 10.1016/j.bbamem.2010.12.015 | 21,192,915 | D002462:Cell Membrane; D003903:Deuterium; D008051:Lipid Bilayers; D009682:Magnetic Resonance Spectroscopy; D010446:Peptide Fragments; D010713:Phosphatidylcholines | Biochimica et biophysica acta | 2,011 | D008051:Lipid Bilayers; D010446:Peptide Fragments; D010713:Phosphatidylcholines; C002448:1,2-linoleoylphosphatidylcholine; D003903:Deuterium; C028694:1-palmitoyl-2-oleoylphosphatidylcholine |
An Exploration of the Factors Considered When Forming Expectations for Returning to Work following Sickness Absence Due to a Musculoskeletal Condition. | INTRODUCTION
Workers' own expectations for returning to work following a period of sickness absence have been found to be one of the best predictors of future work status; however, there is a limited understanding of why people expect what they do. The current study was undertaken with the aim of determining what peopl... | 10.1371/journal.pone.0143330 | 26,580,559 | D000328:Adult; D000368:Aged; D059031:Anticipation, Psychological; D059026:Diagnostic Self Evaluation; D004651:Employment; D005260:Female; D017144:Focus Groups; D006801:Humans; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases; D010808:Physical Examination; D062707:Return to Work; D012647:Self-Assessme... | PloS one | 2,015 | |
Transport of methionine and proline by rat liver slices and the effect of certain hormones. | 1. Transport characteristics of l-methionine and l-proline in rat liver slices in vitro were studied. 2. Intracellular concentration gradients for methionine were obtained. 3. Methionine uptake was inhibited by iodoacetate, dinitrophenol, Na(+)-free media and also by glycine, lysine, cysteine and dithiothreitol but not... | 10.1042/bj1360015 | 4,359,105 | D000596:Amino Acids; D000621:Aminoisobutyric Acids; D000818:Animals; D001693:Biological Transport, Active; D003994:Bucladesine; D003553:Cystine; D004058:Diffusion; D004140:Dinitrophenols; D004229:Dithiothreitol; D004837:Epinephrine; D005934:Glucagon; D006854:Hydrocortisone; D066298:In Vitro Techniques; D007328:Insulin;... | The Biochemical journal | 1,973 | D000596:Amino Acids; D000621:Aminoisobutyric Acids; D004140:Dinitrophenols; D007328:Insulin; D007461:Iodoacetates; D003553:Cystine; D011691:Puromycin; D003994:Bucladesine; D005934:Glucagon; D011392:Proline; D012964:Sodium; D008715:Methionine; D004229:Dithiothreitol; D006854:Hydrocortisone; D004837:Epinephrine |
Uveitis Referral Pattern in Upper and Lower Egypt. | Purpose: To report the pattern of uveitis in two referral eye hospitals, one in Upper Egypt and another in Lower Egypt Methods: Retrospective chart review of all uveitis cases visiting the uveitis clinic in Alexandria and Sohag University Hospitals between May 2010 and March 2017. Results: A total of 1315 patients (683... | 10.1080/09273948.2017.1410183 | 29,297,723 | D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005260:Female; D006782:Hospitals, Special; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009885:Ophthalmology; D015995:Prevalence; D012189:Retrospective Studies; D017... | Ocular immunology and inflammation | 2,019 | |
Regulation of minichromosome maintenance helicase activity by Cdc6. | Genetic studies, together with amino acid and structural similarities to the clamp loaders of DNA polymerase sliding clamps, have suggested that the Cdc6 protein may function as a loader for the eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex. Thus, Cdc6 may act as the functional homologue... | 10.1074/jbc.M305477200 | 12,837,750 | D000255:Adenosine Triphosphate; D019843:Archaeal Proteins; D019847:Chromosomes, Archaeal; D004265:DNA Helicases; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051738:Origin Recognition Complex; D010802:Phylogeny | The Journal of biological chemistry | 2,003 | D019843:Archaeal Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051738:Origin Recognition Complex; D000255:Adenosine Triphosphate; D004265:DNA Helicases; C403162:MCM protein, Methanobacterium thermoautotrophicum |
Benchmark Pathology Report Text Corpus with Cancer Type Classification. | In cancer research, pathology report text is a largely un-tapped data source. Pathology reports are routinely generated, more nuanced than structured data, and contain added insight from pathologists. However, there are no publicly-available datasets for benchmarking report-based models. Two recent advances suggest the... | 10.1101/2023.08.03.23293618 | 37,609,238 | medRxiv : the preprint server for health sciences | 2,023 | ||
MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach. | 14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrates of basophilic protein kinases following their phosphorylation on spe... | 10.3389/fmolb.2023.1148933 | 37,091,863 | Frontiers in molecular biosciences | 2,023 | ||
Radiochemical investigations of (99m)Tc-N(3)S-X-BBN[7-14]NH(2): an in vitro/in vivo structure-activity relationship study where X = 0-, 3-, 5-, 8-, and 11-carbon tethering moieties. | Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin releasing peptide (GRP) that binds to GRP receptors (GRPr) with high affinity and specificity. The GRPr is overexpressed on a variety of human cancer cells, including prostate, breast, lung, and pancreatic cancers. The specific aim of this study w... | 10.1021/bc020034r | 12,526,698 | D000595:Amino Acid Sequence; D000818:Animals; D001839:Bombesin; D003432:Cross-Linking Reagents; D006801:Humans; D007267:Injections; D051379:Mice; D009363:Neoplasm Proteins; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D011485:Protein Binding; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; ... | Bioconjugate chemistry | 2,003 | C475565:(99m)Tc-N(3)S-X-BBN(7-14)NH(2); D003432:Cross-Linking Reagents; D009363:Neoplasm Proteins; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; D001839:Bombesin |
Effect of antioxidants on functional recovery after in vitro-induced ischemia and long-term potentiation recorded in the pyramidal layer of the CA1 area of rat hippocampus. | Ischemic stroke is one of the leading causes of cognitive impairment. Antioxidants may be beneficial in brain diseases in which oxidative stress can be assumed. The effect of two antioxidants, stobadine and its new derivative coded SMe1EC2, was studied on post-ischemic functional recovery in the hippocampus of young an... | 10.4149/gpb_2013062 | 23,940,087 | D000818:Animals; D000975:Antioxidants; D002545:Brain Ischemia; D056547:CA1 Region, Hippocampal; D002243:Carbolines; D003071:Cognition; D004594:Electrophysiology; D007003:Hypoglycemia; D000860:Hypoxia; D007511:Ischemia; D017774:Long-Term Potentiation; D008297:Male; D018384:Oxidative Stress; D010100:Oxygen; D017966:Pyram... | General physiology and biophysics | 2,014 | D000975:Antioxidants; D002243:Carbolines; D010100:Oxygen; C100106:dicarbine |
Alveolar and Bronchial Nitric Oxide in Chronic Obstructive Pulmonary Disease and Asthma-COPD Overlap. | INTRODUCTION
Exhaled nitric oxide (FENO) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients.
METHODS
This was an observational cross-sectional study recruiting ambulator... | 10.1016/j.arbres.2018.02.006 | 29,627,118 | D000368:Aged; D001249:Asthma; D001944:Breath Tests; D001980:Bronchi; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide; D011650:Pulmonary Alveoli; D029424:Pulmonary Disease, Chronic Obstructive | Archivos de bronconeumologia | 2,018 | D009569:Nitric Oxide |
Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach. | Oxidative stress is a determinant of liver steatosis and the progression to more severe forms of disease. The present study investigated the effect of paraoxonase-1 (PON1) deficiency on histological alterations and hepatic metabolism in mice fed a high-fat high-cholesterol diet. We performed nontargeted metabolomics on... | 10.1021/pr400050u | 23,448,543 | D000596:Amino Acids; D000818:Animals; D043303:Aryldialkylphosphatase; D015415:Biomarkers; D002784:Cholesterol; D059305:Diet, High-Fat; D005234:Fatty Liver; D005947:Glucose; D005978:Glutathione; D050356:Lipid Metabolism; D008099:Liver; D008297:Male; D055432:Metabolomics; D051379:Mice; D008810:Mice, Inbred C57BL; D009963... | Journal of proteome research | 2,013 | D000596:Amino Acids; D015415:Biomarkers; D009963:Orotic Acid; D002784:Cholesterol; D043303:Aryldialkylphosphatase; C560867:PON1 protein, mouse; D005978:Glutathione; D005947:Glucose |
Evaluation of stroke using EEG frequency analysis and topographic mapping. | Frequency analysis and topographic mapping of EEG were studied in 20 consecutive patients with mild stroke and in 20 age-matched normal subjects. Abnormally large increases in delta and decreases in alpha activity were seen over the scalp in 17 of 20 patients and in no normal subjects. Theta was unreliable by itself. T... | 10.1212/wnl.37.7.1153 | 3,601,079 | D000368:Aged; D000369:Aged, 80 and over; D001921:Brain; D001931:Brain Mapping; D002561:Cerebrovascular Disorders; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted | Neurology | 1,987 | |
Impact of the 2015 El Niño-Southern Oscillation on the Abundance and Foraging Habits of Guadalupe Fur Seals and California Sea Lions from the San Benito Archipelago, Mexico. | The abundance of California sea lions (Zalophus californianus) (CSLs) and Guadalupe fur seals (Arctocephalus philippii townsendi) (GFSs) from the San Benito Archipelago (SBA) was determined through nine monthly surveys in 2014-2015. Assessment of their foraging habits was examined based on the isotopic analysis of pups... | 10.1371/journal.pone.0155034 | 27,171,473 | D000818:Animals; D001947:Breeding; D002247:Carbon Isotopes; D059000:El Nino-Southern Oscillation; D004777:Environment; D005247:Feeding Behavior; D046069:Fur Seals; D005843:Geography; D062312:Islands; D007553:Isotope Labeling; D008800:Mexico; D009587:Nitrogen Isotopes; D046070:Sea Lions; D012621:Seasons; D013696:Tempera... | PloS one | 2,016 | D002247:Carbon Isotopes; D009587:Nitrogen Isotopes |
Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer. | BACKGROUND
Interaction between tumor cells and tumor microenvironment is critical for homeostasis of normal cells and tumor growth. Tumor cell - stroma interaction represents the potent factor able to initiate cancer and affect tumor progression and disease outcome. The tumors vary by their origin and microenvironment ... | 10.32471/exp-oncology.2312-8852.vol-41-no-4.13796 | 31,868,333 | D000368:Aged; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008099:Liver; D008113:Liver Neoplasms; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury | Experimental oncology | 2,019 | D017382:Reactive Oxygen Species |
The hepatoprotective effects of fennel seeds extract and trans-Anethole in streptozotocin-induced liver injury in rats. | Hypoglycemic, anti-inflammatory, and antioxidant activities of fennel have been recorded in numerous investigations. The study aimed to evaluate the protective effects of fennel or its active component trans-Anethole (TA) on streptozotocin-induced liver injury in rats. Rats were injected with a single dose of STZ (65 m... | 10.1002/fsn3.2090 | 33,598,196 | Food science & nutrition | 2,021 | ||
Nitrogen translocation by Highland cattle grazing in Alnus viridis-encroached pastures. | During the last decades, Alnus viridis has expanded over former montane pastures and meadows, due to land use and abandonment. This nitrogen-fixing woody species has triggered negative agro-environmental impacts, such as nitrogen (N) leaching, soil acidification and a reduced biodiversity. The aim of this study was to ... | 10.1007/s10705-023-10282-0 | 37,124,631 | Nutrient cycling in agroecosystems | 2,023 | ||
Effects of salinity on nest-building behaviour in a marine fish. | BACKGROUND
Parental allocation and reproductive success are often strongly influenced by environmental factors. In this respect, salinity is a key factor influencing species distributions and community structure in aquatic animals. Nevertheless, the effects of salinity on reproductive behaviours are not well known. Her... | 10.1186/s12898-016-0067-y | 26,928,449 | D000818:Animals; D008297:Male; D009425:Nesting Behavior; D010473:Perciformes; D054712:Salinity | BMC ecology | 2,016 | |
'Inglan is a bitch': hostile NHS charging regulations contravene the ethical principles of the medical profession. | Following the recent condemnation of the National Health Service charging regulations by medical colleges and the UK Faculty of Public Health, we demonstrate that through enactment of this policy, the medical profession is betraying its core ethical principles. Through dissection of the policy using Beauchamp and Child... | 10.1136/medethics-2019-105419 | 31,331,951 | D026686:Beneficence; D016022:Case-Control Studies; D003657:Decision Making; D004608:Eligibility Determination; D004641:Emigration and Immigration; D033161:Government Regulation; D006297:Health Services Accessibility; D049673:History, 20th Century; D006801:Humans; D028681:Moral Obligations; D026684:Personal Autonomy; D0... | Journal of medical ethics | 2,019 | |
Introduction to Diagnostic and Therapeutic Spinal Angiography. | This article describes the basic principles of diagnostic and therapeutic spinal angiography as practiced by the author, including catheterization and radioprotection techniques, the selection of endovascular devices and embolization agents, and procedural complications. | 10.1016/j.nic.2019.07.008 | 31,677,733 | D000792:Angiography; D020785:Central Nervous System Vascular Malformations; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D006801:Humans; D013116:Spinal Cord; D016896:Treatment Outcome | Neuroimaging clinics of North America | 2,019 | |
Aryl hydrocarbon receptor affects circadian-regulated lipolysis through an E-Box-dependent mechanism. | An internal circadian clock regulates timing of systemic energy homeostasis. The central clock in the hypothalamic suprachiasmatic nucleus (SCN) directs local clocks in peripheral tissues such as liver, muscle, and adipose tissue to synchronize metabolism with food intake and rest/activity cycles. Aryl hydrocarbon rece... | 10.1016/j.mce.2022.111809 | 36,283,500 | D051379:Mice; D000818:Animals; D018336:Receptors, Aryl Hydrocarbon; D002940:Circadian Rhythm; D008066:Lipolysis; D057906:Circadian Clocks; D056926:CLOCK Proteins; D008810:Mice, Inbred C57BL | Molecular and cellular endocrinology | 2,023 | D018336:Receptors, Aryl Hydrocarbon; D056926:CLOCK Proteins |
Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. | Polymorphisms in glutathione S-transferase (GSTs) may predispose to colorectal cancer through deficient detoxification of environmental carcinogens, although previous results are conflicting. A study with 178 matched case-control pairs was conducted to determine the effect of the GSTT1 and GSTM1 null genotypes and poly... | 10,207,630 | D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D015179:Colorectal Neoplasms; D016001:Confidence Intervals; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Trans... | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 1,999 | D005819:Genetic Markers; D007527:Isoenzymes; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C117740:glutathione S-transferase M1 | |
Left coronary aneurysmal dilation and subaortic stenosis in a dog. | A 6-month-old German shepherd dog was referred for evaluation of a cardiac murmur. Upon physical examination, the auscultated heart rate was 120 beats/min, and a grade IV/VI systolic heart murmur with a point of maximal intensity over the left heart base radiating up the neck was heard. The standard echocardiographic e... | 10.1016/j.jvc.2007.12.001 | 18,485,856 | D000792:Angiography; D000818:Animals; D001020:Aortic Stenosis, Subvalvular; D003323:Coronary Aneurysm; D004108:Dilatation, Pathologic; D004283:Dog Diseases; D004285:Dogs; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D017809:Fatal Outcome; D006337:Heart Murmurs | Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology | 2,008 | |
Comparison of the rates of inactivation and conformational changes of creatine kinase during urea denaturation. | The denaturation of creatine kinase in urea solutions of different concentrations has been studied by following the changes in the ultraviolet absorbance and intrinsic fluorescence as well as by the exposure of hidden SH groups. In concentrated urea solutions, the denaturation of the enzyme results in negative peaks at... | 10.1021/bi00307a032 | 6,466,613 | D000818:Animals; D003402:Creatine Kinase; D007700:Kinetics; D011487:Protein Conformation; D011489:Protein Denaturation; D013050:Spectrometry, Fluorescence; D014508:Urea | Biochemistry | 1,984 | D014508:Urea; D003402:Creatine Kinase |
Effects of changes in muscle activation level and spine and hip posture on erector spinae fiber orientation. | INTRODUCTION
During lumbar flexion, the fiber orientation of the lumbar erector spinae (LES) muscle becomes oriented more along the spine compressive axis. It is unknown how changes in LES activation effect fiber orientation.
METHODS
Ultrasound images of LES were collected during 2 sets of experimental conditions: (1... | 10.1002/mus.24309 | 24,910,343 | D064131:Back Muscles; D001696:Biomechanical Phenomena; D004576:Electromyography; D006615:Hip; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D009119:Muscle Contraction; D018485:Muscle Fibers, Skeletal; D009949:Orientation; D011187:Posture; D014463:Ultrasonography; D055815:Young Adult | Muscle & nerve | 2,015 | |
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice. | The 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)-butyric acid, homo-AMPA, an analog of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and 2-aminoadipic acid, has shown no activity towards ionotropic and metabotropic glutamate 1, 2, 3, 4, 5, and 7 receptors (mGluR1-7), agonist activity at mGluR6 while the ac... | 10.1016/j.neuropharm.2022.109047 | 35,364,102 | D000818:Animals; D003920:Diabetes Mellitus; D003929:Diabetic Neuropathies; D006930:Hyperalgesia; D008526:Medulla Oblongata; D051379:Mice; D010146:Pain; D010487:Periaqueductal Gray; D051381:Rats; D017208:Rats, Wistar; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | Neuropharmacology | 2,022 | C100921:2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid |
S100B protein related neonatal hypoxia. | Biochemical markers have played an increasingly relevant role in the assessment of neonatal asphyxia. The S100B protein is particularly important in research conducted in this field. The purpose of this study was to underline the importance of the S100B protein in the assessment of term newborn infants with hypoxic-isc... | 10.1590/s0004-282x2006000100006 | 16,622,548 | D001034:Apgar Score; D001238:Asphyxia Neonatorum; D015415:Biomarkers; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood; D006801:Humans; D020925:Hypoxia-Ischemia, Brain; D007231:Infant, Newborn; D008297:Male; D009414:Nerve Growth Factors; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein ... | Arquivos de neuro-psiquiatria | 2,006 | D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human |
Resonance clustering in globally coupled electrochemical oscillators with external forcing. | Experiments are carried out with a globally coupled, externally forced population of limit-cycle electrochemical oscillators with an approximately unimodal distribution of heterogeneities. Global coupling induces mutually entrained (at frequency omega1) states; periodic forcing produces forced-entrained (omegaF) states... | 10.1103/PhysRevE.77.046204 | 18,517,707 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,008 | ||
Emotion regulation and adolescent suicide: a proposal for physician education. | Suicide is the second leading cause of death among adolescents aged 14-19 years. Pediatricians report strong interest in receiving additional training to reduce suicide mortality, and physician education is one of the most robust means of suicide prevention. However, many studies suggest that existing educational metho... | 25,411,989 | D000293:Adolescent; D000294:Adolescent Behavior; D000342:Affective Symptoms; D004501:Education, Medical; D006801:Humans; D013405:Suicide; D055815:Young Adult | International journal of adolescent medicine and health | 2,015 | ||
[Malignant pertussis in a three-week-old girl]. | Whooping cough is an infectious disease caused by Bordetella pertussis. Particularly children under the age of six months can be severely affected by the infection. Severe leukocytosis may lead to thrombosis and pulmonary hypertension and eventually circulatory failure and death. This a case report of a three-week-old ... | 33,491,624 | D001886:Bordetella pertussis; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D007964:Leukocytosis; D012131:Respiratory Insufficiency; D014611:Vaccination; D014917:Whooping Cough | Ugeskrift for laeger | 2,021 | ||
[Evaluation of the relationship between deep venous thrombosis and pulmonary embolism with radionuclide techniques]. | OBJECTIVE
The purpose of this study was to evaluate the relation between deep venous thrombosis (DVT) and pulmonary thromboembolism (PTE) by radionuclide imaging.
METHODS
One hundred forty patients with PTE from September 1997 to March 2001 at this institution was confirmed by clinical manifestation, pulmonary perfus... | 12,133,330 | D000328:Adult; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D010690:Phlebography; D010992:Plethysmography, Impedance; D011655:Pulmonary Embolism; D012123:Pulmonary Ventilation; D011875:Radionuclide Angiography; D020246:Venous Thrombosis | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases | 2,002 | ||
Localization of nucleic acid sequences by EM in situ hybridization using colloidal gold labels. | It is possible to combine hybridization to specimens on electron-microscope grids of nucleic-acid probes labelled nonisotopically with immunogold detection of hybrid sites to map the position of target sequences rapidly and precisely. The basic technique is described, and examples are provided to illustrate the types o... | 10.1002/aja.1001850212 | 2,476,019 | D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA; D006046:Gold; D051379:Mice; D008854:Microscopy, Electron; D009693:Nucleic Acid Hybridization; D012313:RNA; D014982:Xenopus laevis | The American journal of anatomy | 1,989 | D012313:RNA; D006046:Gold; D004247:DNA |
Separation of Three Species of Ditylenchus and Some Host Races of D. dipsaci by Restriction Fragment Length Polymorphism. | This study examined the ribosomal cistron of Ditylenchus destructor, D. myceliophagus and seven host races of D. dipsaci from different geographic locations. The three species showed restriction fragment length polymorphisms (RFLPs) in the ribosomal cistron, the 18S rDNA gene, and the ribosomal internal transcribed spa... | 19,279,809 | Journal of nematology | 1,993 | |||
On complicity theory. | The received account of whistleblowing, developed over the last quarter century, is identified with the work of Norman Bowie and Richard DeGeorge. Michael Davis has detailed three anomalies for the received view: the paradoxes of burden, missing harm and failure. In addition, he has proposed an alternative account of w... | 10.1007/s11948-006-0025-8 | 16,609,713 | D028661:Complicity; D004738:Engineering; D026689:Ethical Analysis; D028663:Ethical Theory; D006801:Humans; D035642:Whistleblowing | Science and engineering ethics | 2,006 | |
The neutralization of pseudorabies virus by anti-alpha-galactocyl natural antibody in normal serum. | Pseudorabies virus (PrV), a member of herpesviridae alphaherpes subfamily, can infect human cells in vitro. However, the transmission to Old World primates including humans is strongly restricted. In this study, we report the neutralizing activity of normal human serum against PrV grown in CPK cells derived from pig. P... | 10.1016/j.virusres.2003.09.008 | 14,687,940 | D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface; D002460:Cell Line; D002522:Chlorocebus aethiops; D004187:Disaccharides; D000939:Epitopes; D011558:Herpesvirus 1, Suid; D006801:Humans; D009500:Neutralization Tests; D011557:Pseudorabies; D013552:Swine; D014312:Trisaccharides; D014709:Vero Cells; D014771:Vi... | Virus research | 2,004 | D000906:Antibodies; D000954:Antigens, Surface; D004187:Disaccharides; D000939:Epitopes; D014312:Trisaccharides; C076569:alpha-galactosyl epitope; C055075:galactosyl-(1-3)galactose |
Audiological evaluation in spinocerebellar ataxia. | PURPOSE
To describe the audiological and electrophysiological results in patients with spinocerebellar ataxia (SCA).
METHODS
Retrospective and cross-sectional studies were performed. Forty-three patients were assessed using the following procedures: anamnesis and otolaryngologic exam, pure tone audiometry, acoustic i... | 24,413,425 | D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D001307:Auditory Perception; D003430:Cross-Sectional Studies; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012189:Retrospective Studies; D020754:Spinocerebellar Atax... | CoDAS | 2,013 | ||
Clinical trial: ulcerative colitis maintenance treatment with 5-ASA: a 1-year, randomized multicentre study comparing MMX with Asacol. | BACKGROUND
5-ASA-MMX (1.2 g/tablet) is a 5-aminosalicylic acid formulation, designed for once-daily dosing in the treatment of ulcerative colitis.
AIM
To evaluate the efficacy and safety of 5-ASA-MMX (2.4 g/day, once daily), compared with Asacol (2.4 g/day, twice daily) in the maintenance of left-sided UC, through a ... | 10.1111/j.1365-2036.2009.04117.x | 19,678,813 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003093:Colitis, Ulcerative; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D010349:Patient Compliance; D012008:Recurrence; D016896:Treatment Out... | Alimentary pharmacology & therapeutics | 2,009 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D019804:Mesalamine |
Photoreconfigurable polymers for biomedical applications: chemistry and macromolecular engineering. | Stimuli-responsive polymers play an important role in many biomedical technologies. Light responsive polymers are particularly desirable because the parameters of irradiated light and diverse photoactive chemistries produce a large number of combinations between functional materials and associated stimuli. This Review ... | 10.1021/bm500990z | 25,226,507 | D000818:Animals; D001672:Biocompatible Materials; D035843:Biomedical Research; D006801:Humans; D008027:Light; D046911:Macromolecular Substances; D011108:Polymers; D023822:Tissue Engineering | Biomacromolecules | 2,014 | D001672:Biocompatible Materials; D046911:Macromolecular Substances; D011108:Polymers |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.