title large_stringlengths 0 979 | abstract large_stringlengths 1 94.7k | doi large_stringlengths 0 71 | pmid int64 21 38.1M | mesh_terms large_stringlengths 0 1.47k | journal large_stringlengths 1 239 | pubdate int16 1.97k 2.02k | chemical_list large_stringlengths 0 1.47k |
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Melt-spun bioactive sutures containing nanohybrids for local delivery of anti-inflammatory drugs. | In this work, a novel concept is introduced in drug-eluting fibres to ensure a good control of drug delivery features and wide applicability to different bioactive compounds. Composite bioactive sutures based on fibre grade poly(ε-caprolactone) (PCL) and loaded with the anti-inflammatory drug Diclofenac (Dic) or a Dic ... | 25,175,217 | D000818:Animals; D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D013052:Spectrometry, X-Ray Emission; D013537:Sutures | Materials science & engineering. C, Materials for biological applications | 2,014 | D000893:Anti-Inflammatory Agents; D004337:Drug Carriers | |
Amyloid deposits in calcified aortic valves. | Thirty-nine severely calcified aortic valves surgically removed were studied for amyloid deposits using the alkaline Congo red stain. Amyloid deposits were found in all the valves, in such quantities that they could be demonstrated using screening magnification (x40). A close topographic relationship was found between ... | 10.1111/j.1699-0463.1981.tb00182.x | 7,223,424 | D000328:Adult; D000368:Aged; D000682:Amyloid; D001021:Aortic Valve; D001024:Aortic Valve Stenosis; D002114:Calcinosis; D002118:Calcium; D005260:Female; D005347:Fibroblasts; D006801:Humans; D008297:Male; D008875:Middle Aged | Acta pathologica et microbiologica Scandinavica. Section A, Pathology | 1,981 | D000682:Amyloid; D002118:Calcium |
Diabetic macroangiopathy. Medial calcifications, narrowing, rugosities, stiffness, norepinephrine depletion and reduced blood flow capacity in the leg arteries. | Five quantitative studies performed to disclose and measure diabetic abnormalities in the leg arteries are reported and briefly discussed. A medial as well as an intimal disease was found in the diabetic leg arteries. Thus roentgenological medial calcification correlated to glucose intolerance in older non-diabetics an... | 6,591,757 | D000328:Adult; D001158:Arteries; D002114:Calcinosis; D003922:Diabetes Mellitus, Type 1; D003925:Diabetic Angiopathies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine; D011859:Radiography; D012039:Regional Blood Flow; D013997:Time Fa... | Acta medica Scandinavica. Supplementum | 1,984 | D009638:Norepinephrine | |
Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. | The pathogenesis of central nervous system disease during human immunodeficiency virus type 1 (HIV-1) infection revolves around productive viral infection of brain macrophages and microglia. Neuronal losses in the cortex and subcortical gray matter accompany macrophage infection. The question of how viral infection of ... | 10.1128/JVI.68.7.4628-4635.1994 | 8,207,837 | D015526:AIDS Dementia Complex; D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D000818:Animals; D001253:Astrocytes; D002470:Cell Survival; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005333:Fetus; D015497:HIV-1; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009000:Monocytes; D0... | Journal of virology | 1,994 | D010972:Platelet Activating Factor |
Wnt-5a has tumor suppressor activity in thyroid carcinoma. | Stabilization of beta-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/beta-catenin signaling pathway and is associated with various human carcinomas. It contrasts to an as yet incompletely characterized action of an alternative noncanonical Wnt signaling pathway on n... | 10.1038/sj.onc.1208370 | 15,735,754 | D002455:Cell Division; D045744:Cell Line, Tumor; D002465:Cell Movement; D003598:Cytoskeletal Proteins; D016147:Genes, Tumor Suppressor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009361:Neoplasm Invasiveness; D021381:Protein Transport; D011518:Proto-Oncogene Proteins; D013961:Thyroid Gland;... | Oncogene | 2,005 | C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D036341:Intercellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins; C085389:WNT5A protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D051176:beta Catenin |
Gender differences in insomnia and the role of paid work and family responsibilities. | PURPOSE
A higher prevalence of insomnia in females has been consistently demonstrated across countries and cultures. The aim of this study was to clarify whether gender differences in insomnia could be explained by gender differences in paid work and family responsibilities.
METHODS
Participants were employees at two... | 10.1007/s00127-011-0370-z | 21,476,013 | D000328:Adult; D017028:Caregivers; D002648:Child; D002654:Child Care; D016288:Computer Terminals; D003430:Cross-Sectional Studies; D004651:Employment; D005191:Family Characteristics; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan; D009111:Local Government; D008297:Male; D017533:Marital Status; D0... | Social psychiatry and psychiatric epidemiology | 2,012 | |
Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020. | The aim of this study was to investigate the serotype-associated fatality rate in cases of invasive pneumococcal disease (IPD) in the Spanish region of Madrid between 2007 and 2020. Serotyping was performed by Pneumotest Latex and the Quellung reaction using commercial antisera. Case-fatality rate was estimated as the ... | 10.3390/microorganisms9112286 | 34,835,413 | Microorganisms | 2,021 | ||
D-tyrosyl-tRNA(Tyr) metabolism in Saccharomyces cerevisiae. | The Saccharomyces cerevisiae YDL219w (DTD1) gene, which codes for an amino acid sequence sharing 34% identity with the Escherichia coli D-Tyr-tRNA(Tyr) deacylase, was cloned, and its product was functionally characterized. Overexpression in the yeast of the DTD1 gene from a multicopy plasmid increased D-Tyr-tRNA(Tyr) d... | 10.1074/jbc.275.16.11626 | 10,766,779 | D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli; D015723:Gene Library; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012365:RNA, Transfer, Tyr; D012441:Saccharomyces cerevisiae; D012984:Software; D014443:Tyrosine; D014448:Tyrosine-tRNA Ligase | The Journal of biological chemistry | 2,000 | D012365:RNA, Transfer, Tyr; D014443:Tyrosine; D014448:Tyrosine-tRNA Ligase |
Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient. | We treated a 49-yr-old man with neostigmine, who had liver cirrhosis, acute hepatic encephalopathy, and acute intestinal pseudoobstruction. He was admitted in a state of hepatic confusion. On physical examination, the abdomen was distended; and bowel sound was absent. Plain abdomen film revealed multiple air-fluid leve... | 10.3346/jkms.2005.20.1.150 | 15,716,622 | D000388:Air; D000641:Ammonia; D001794:Blood Pressure; D002800:Cholinesterase Inhibitors; D004573:Electrolytes; D004733:Enema; D005355:Fibrosis; D006501:Hepatic Encephalopathy; D006801:Humans; D007418:Intestinal Pseudo-Obstruction; D007792:Lactulose; D008099:Liver; D008297:Male; D008875:Middle Aged; D009388:Neostigmine;... | Journal of Korean medical science | 2,005 | D002800:Cholinesterase Inhibitors; D004573:Electrolytes; D009388:Neostigmine; D011092:Polyethylene Glycols; D007792:Lactulose; D000641:Ammonia |
Bifurcations accompanying monotonic instability of an equilibrium of a cosymmetric dynamical system. | It is well known that equilibrium in a cosymmetric system in the general position is a member of a one-parameter family. In the present paper the Lyapunov-Schmidt method and the method of the central manifold are used to analyze bifurcations of such a family of equilibria as well as internal bifurcations: transitions o... | 10.1063/1.166497 | 12,779,386 | Chaos (Woodbury, N.Y.) | 2,000 | ||
Psychosocial adjustment among pediatric cancer patients: a multidimensional assessment. | Identified types and frequencies of psychological difficulties manifested by pediatric oncology patients and child-, family-, and illness-related correlates of adjustment. Parents of 48 children with cancer, 4 to 17 years of age, completed the Personality Inventory for Children (PIC). Analysis of mean PIC scores indica... | 10.1093/jpepsy/16.4.463 | 1,941,426 | D000223:Adaptation, Psychological; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms; D010555:Personality Inventory; D012307:Risk Factors; D013315:Stress, Psychological | Journal of pediatric psychology | 1,991 | |
Pacemakers and magnetic resonance imaging: no longer an absolute contraindication when scanned correctly. | BACKGROUND
Until recently, cardiac pacemakers and implantable cardioverter defibrillators were considered an absolute contraindication for magnetic resonance imaging. Given the significant increase in implanting such devices, these contraindications will preclude MRI scanning in a large patient population. Several rece... | 20,862,817 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial | The Israel Medical Association journal : IMAJ | 2,010 | ||
Abundance and genetic diversity of nifH gene sequences in anthropogenically affected Brazilian mangrove sediments. | Although mangroves represent ecosystems of global importance, the genetic diversity and abundance of functional genes that are key to their functioning scarcely have been explored. Here, we present a survey based on the nifH gene across transects of sediments of two mangrove systems located along the coast line of São ... | 10.1128/AEM.02273-12 | 22,941,088 | D032407:Avicennia; D001419:Bacteria; D058448:Biota; D001938:Brazil; D029764:Combretaceae; D004269:DNA, Bacterial; D058645:Denaturing Gradient Gel Electrophoresis; D014644:Genetic Variation; D008969:Molecular Sequence Data; D010088:Oxidoreductases; D016133:Polymerase Chain Reaction; D043982:Rhizophoraceae; D017422:Seque... | Applied and environmental microbiology | 2,012 | D004269:DNA, Bacterial; D010088:Oxidoreductases; C029130:nitrogenase reductase |
Developments in hernia repair. | Traditionally, inguinal hernia repair uses autogenous tissues (Shouldice, Bassini, Cooper's). While dedicated
hernia clinics have shown low recurrence rates using autogenous tissues, most studies show
recurrence rates in the 5% to 15% range. In addition, these tension producing repairs may lead to a
longer recovery due... | 12,721,972 | Surgical technology international | 1,998 | |||
Fetal exposures to sound and vibroacoustic stimulation. | Sounds in the environment of a pregnant woman penetrate the tissues and fluids surrounding the fetal head and stimulate the inner ear through a bone conduction route. The sounds available to the fetus are dominated by low-frequency energy, whereas energy above 0.5 kHz is attenuated by 40 to 50 dB. The fetus easily dete... | 10.1038/sj.jp.7200446 | 11,190,697 | D000161:Acoustic Stimulation; D000162:Acoustics; D000818:Animals; D007758:Ear, Inner; D005314:Embryonic and Fetal Development; D005333:Fetus; D006309:Hearing; D006801:Humans; D008954:Models, Biological; D009622:Noise; D013016:Sound; D014732:Vibration | Journal of perinatology : official journal of the California Perinatal Association | 2,000 | |
Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma. | Donor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post B... | 10.1046/j.1365-2141.2002.03925.x | 12,437,659 | D000208:Acute Disease; D016026:Bone Marrow Transplantation; D002283:Carcinoma, Bronchogenic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D007951:Leukemia, Myeloid; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012008:Re... | British journal of haematology | 2,002 | |
Massive gas embolism revealed by two consecutive postmortem computed-tomography examinations. | We present a case of unusual gas embolism in a 73-year-old man who was found in a state of cardiopulmonary arrest with an oxygen-supply tube connected to an intravenous catheter inserted into his median cubital vein. Postmortem computed tomography (PMCT) performed 27 h after death showed systemic gas distribution inclu... | 23,806,344 | D000368:Aged; D002408:Catheters, Indwelling; D004618:Embolism, Air; D004646:Emphysema; D049429:Forensic Pathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008478:Mediastinal Emphysema; D061330:Multidetector Computed Tomography; D010102:Oxygen Inhalation Therapy; D035422:Pleural Cavity; D01102... | Forensic science international | 2,013 | ||
[Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron]. | We studied the interaction with liposomes and the antioxidant activity of flavonoid (quercetin, catechin, taxifolin) complexes with iron (III). It was found that the lipophilicity of complexes depends on an iron:flavonoid ratio and grows at a ratio of 1 to 1, while complexes in a 2:1 ratio were the most effective to sl... | 25,481,949 | D000975:Antioxidants; D001713:Biphenyl Compounds; D002392:Catechin; D005419:Flavonoids; D007501:Iron; D015227:Lipid Peroxidation; D008081:Liposomes; D010084:Oxidation-Reduction; D010851:Picrates | Biofizika | 2,013 | D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D008081:Liposomes; D010851:Picrates; D002392:Catechin; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron | |
Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation. | Biomarker profiling is being rapidly incorporated in many areas of modern medical practice to improve the precision of clinical decision-making. This potential improvement, however, has not been transferred to the practice of organ assessment and transplantation because previously developed gene-profiling techniques re... | 10.1126/sciadv.1500417 | 26,601,233 | Science advances | 2,015 | ||
Production of two Nasal Sounds by Speakers with Cleft Palate. | Many speakers with cleft palate develop atypical consonant productions, especially for pressure consonants such as plosives, fricatives, and affricates. The present study investigated the nature of nasal sound errors. The participants were eight female and three male speakers with cleft palate between the ages of 6 to ... | 10.1597/16-096 | 28,033,025 | D000293:Adolescent; D001184:Articulation Disorders; D002648:Child; D002971:Cleft Lip; D002972:Cleft Palate; D005260:Female; D006801:Humans; D008297:Male; D013068:Speech Production Measurement; D014059:Tongue; D014463:Ultrasonography; D055815:Young Adult | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | 2,018 | |
A magnetic electrode modified with hemoglobin for determination of hydrogen peroxide: distinctly improved response by applying a magnetic field. | A facile and highly sensitive biosensor was developed for the determination of hydrogen peroxide (H2O2) via electrochemical catalytic reduction of H2O2 by hemoglobin (Hb). Hb was enriched and immobilized simply in a chitosan (Chit) membrane on a magnetic electrode to construct an enzyme-like biosensor. The biosensor ca... | 10.1007/s00604-019-4061-x | 31,900,660 | D000818:Animals; D015374:Biosensing Techniques; D004202:Disinfectants; D055664:Electrochemical Techniques; D004566:Electrodes; D006454:Hemoglobins; D006861:Hydrogen Peroxide; D008280:Magnetics; D008892:Milk; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet | Mikrochimica acta | 2,020 | D004202:Disinfectants; D006454:Hemoglobins; D006861:Hydrogen Peroxide |
Impact of chronic hyperglycemia on Small Heat Shock Proteins in diabetic rat brain. | Small heat shock proteins (sHsps) are a family of proteins. Some are induced in response to multiple stimuli and others are constitutively expressed. They are involved in fundamental cellular processes, including protein folding, apoptosis, and maintenance of cytoskeletal integrity. Hyperglycemia created during diabete... | 10.1016/j.abb.2021.108816 | 33,631,184 | D000818:Animals; D001921:Brain; D002908:Chronic Disease; D003921:Diabetes Mellitus, Experimental; D005786:Gene Expression Regulation; D050888:Heat-Shock Proteins, Small; D006943:Hyperglycemia; D008297:Male; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley | Archives of biochemistry and biophysics | 2,021 | D050888:Heat-Shock Proteins, Small; D009419:Nerve Tissue Proteins |
Safe De-Labeling of Patients at Low Risk of Penicillin Allergy in Denmark. | INTRODUCTION
Penicillin allergy is suspected in 10% of hospital inpatients but can be disproved in 90% of cases. Direct oral provocation without preceding tests among low-risk patients has proven to be safe in studies of both children and adults and is gaining use across the world. The aims of this study were to invest... | 10.1159/000521708 | 35,108,710 | D000328:Adult; D000707:Anaphylaxis; D000900:Anti-Bacterial Agents; D002648:Child; D003718:Denmark; D004342:Drug Hypersensitivity; D006801:Humans; D006968:Hypersensitivity, Delayed; D010406:Penicillins; D011446:Prospective Studies; D012189:Retrospective Studies; D012882:Skin Tests | International archives of allergy and immunology | 2,022 | D000900:Anti-Bacterial Agents; D010406:Penicillins |
Effect of age and blood pressure on determination of normal fluid status in a general population using whole body and calf bioimpedance techniques. | Normal fluid status (dry weight) can be identified by hydration markers established in the healthy population. The general population average could be influenced by age with its accompanying physiological changes and/or illness. The aims of this study were (1) to evaluate the effect of age and systolic blood pressure (... | 10.1088/1361-6579/aa6912 | 28,530,202 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001794:Blood Pressure; D001826:Body Fluids; D001827:Body Height; D001835:Body Weight; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D055815:Young Adult | Physiological measurement | 2,017 | |
Translational recoding: canonical translation mechanisms reinterpreted. | During canonical translation, the ribosome moves along an mRNA from the start to the stop codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein sequence is essential for the quality of the cellular proteome. Spontaneous errors in decoding or translocation are rare and result in a def... | 10.1093/nar/gkz783 | 31,511,883 | D018388:Codon, Terminator; D018965:Frameshifting, Ribosomal; D014176:Protein Biosynthesis; D012270:Ribosomes | Nucleic acids research | 2,020 | D018388:Codon, Terminator |
InGaN micro-LED array with integrated emission and detection functions for color detection application. | InGaN-based micro-LEDs can detect and emit optical signals simultaneously, owing to their overlapping emission and absorption spectra, enabling color detection. In this paper, we fabricated a green InGaN-based micro-LED array with integrated emission and detection functions. On the back side of the integrated device, w... | 10.1364/OL.485939 | 37,262,229 | Optics letters | 2,023 | ||
Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. | Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathered from genetics, murine models, and iPSC-derived neurons point to the early involvement of synapses in the disease cou... | 10.1186/s40478-023-01616-8 | 37,491,361 | D006801:Humans; D051379:Mice; D000818:Animals; D000690:Amyotrophic Lateral Sclerosis; D012189:Retrospective Studies; D009046:Motor Neurons; D013116:Spinal Cord | Acta neuropathologica communications | 2,023 | |
Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of traditional Chinese medicine. | OBJECTIVE
This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms of Traditional Chinese Medicine.
METHODS
We randomly divided 48 SPF 10-week-old male Sprague-Dawley (SD) rats into a normal group, normal + Aristolochic acid I (A... | 10.1016/s0254-6272(14)60081-9 | 24,783,936 | D000818:Animals; D015536:Down-Regulation; D005753:Gastric Mucosa; D006801:Humans; D007668:Kidney; D008099:Liver; D008297:Male; D027361:Organic Anion Transporters; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen; D016711:Yang Deficiency | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan | 2,014 | D027361:Organic Anion Transporters; C533062:oatp2b1 protein, rat |
Effects of plumbagin on antibiotic resistance in bacteria. | Plumbagin, a compound derived from the roots of Plumbago zeylanica (Chitramool) was studied for its effect on the development of antibiotic resistance using antibiotic sensitive strains of Escherichia coli and Staphylococcus aureus. A delayed growth was seen when these organisms were inoculated into the antibiotic (str... | 2,188,907 | D000900:Anti-Bacterial Agents; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D009285:Naphthoquinones; D010936:Plant Extracts; D013211:Staphylococcus aureus | The Indian journal of medical research | 1,990 | D000900:Anti-Bacterial Agents; D003470:Culture Media; D009285:Naphthoquinones; D010936:Plant Extracts; C014758:plumbagin | |
Coaggregation: specific adherence among human oral plaque bacteria. | Nearly all human oral bacteria exhibit coaggregation, cell-to-cell recognition of genetically distinct cell types. Clumps or coaggregates composed of the two kinds of cells are formed immediately upon mixing two partner cell types. Members of all 18 genera tested exhibit lactose-reversible coaggregation. Many of these ... | 10.1096/fasebj.7.5.8462782 | 8,462,782 | D001422:Bacterial Adhesion; D002240:Carbohydrate Sequence; D003773:Dental Plaque; D006801:Humans; D008969:Molecular Sequence Data | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 1,993 | |
VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: evidence of developmental hypoxia. | In macaque monkeys the foveal depression forms between fetal day (Fd) 105 and birth (Fd 172 of gestation). Before this, the incipient fovea is identified by a photoreceptor layer comprising cones almost exclusively, a multilayered ganglion cell layer (GCL), and a "domed" profile. Vessels are absent from the central ret... | 10.1002/cne.10705 | 12,761,823 | D000222:Adaptation, Physiological; D025042:Amacrine Cells; D000818:Animals; D016228:Endothelial Growth Factors; D005584:Fovea Centralis; D018507:Gene Expression Regulation, Developmental; D002534:Hypoxia, Brain; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D0... | The Journal of comparative neurology | 2,003 | D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors |
Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies. | Overexpression of c-Myc and inactivation of p53 are hallmarks of human Burkitt's lymphomas. We had previously showed that transduction of murine p53-null bone marrow cells with a Myc-encoding retrovirus is sufficient for B lymphomagenesis. To address the role of Myc in tumor sustenance, we generated lymphomas induced b... | 10.1158/0008-5472.CAN-04-4197 | 15,958,595 | D000483:Alleles; D000818:Animals; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D002454:Cell Differentiation; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D016259:Genes, myc; D016753:Interleukin-10; D016393:Lymphoma, B-Cell; D051379:Mi... | Cancer research | 2,005 | D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D018123:Receptors, Interleukin; D013629:Tamoxifen; D016753:Interleukin-10; C016601:afimoxifene; D000069283:Rituximab |
Fundus Autofluorescence and SD-OCT Document Rapid Progression in Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC) Associated with a c.256G > A Mutation in BEST1. | PURPOSE
To report the variability of clinical findings, rapid concentric progression, and successful treatment of macular edema in autosomal dominant vitreoretinochoroidopathy (ADVIRC) associated with a heterozygous c.256G > A missense mutation in the bestrophin-1 (BEST1) gene.
METHODS
Three affected members of a fou... | 10.3109/13816810.2015.1033556 | 26,771,239 | D000328:Adult; D000075002:Bestrophins; D002257:Carbonic Anhydrase Inhibitors; D002648:Child; D018118:Chloride Channels; D015862:Choroid Diseases; D018450:Disease Progression; D004596:Electroretinography; D015785:Eye Diseases, Hereditary; D005136:Eye Proteins; D005260:Female; D005451:Fluorescein Angiography; D005500:Fol... | Ophthalmic genetics | 2,016 | C113133:BEST1 protein, human; D000075002:Bestrophins; D002257:Carbonic Anhydrase Inhibitors; D018118:Chloride Channels; D005136:Eye Proteins; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide |
Simulated control of unilateral, anticipatory locomotor adjustments during obstructed gait. | Anticipatory adjustments of our locomotor patterns are necessary in order to negotiate our uneven daily environments. Recent work (McFadyen and Winter 1991) has shown the re-organization of lower limb mechanics for obstacle avoidance during level walking. The present work describes a model which sets the ground work fo... | 10.1007/BF00205979 | 7,880,919 | D000886:Anthropometry; D003198:Computer Simulation; D006801:Humans; D008124:Locomotion; D008954:Models, Biological; D009132:Muscles | Biological cybernetics | 1,994 | |
Melasma: a clinical and epidemiological review. | Melasma is a chronic acquired hypermelanosis of the skin, characterized by irregular brown macules symmetrically distributed on sun-exposed areas of the body, particularly on the face. It is a common cause of demand for dermatological care that affects mainly women (especially during the menacme), and more pigmented ph... | 25,184,917 | D005260:Female; D006801:Humans; D008297:Male; D008548:Melanosis; D011788:Quality of Life; D012307:Risk Factors; D012737:Sex Factors; D012867:Skin | Anais brasileiros de dermatologia | 2,014 | ||
Drivers of aggregation in a novel arboreal parasite: the influence of host size and infra-populations. | As a novel arboreal parasite, New Zealand's largest endemic moth, Aenetus virescens, is a biological oddity. With arguably the most unusual lepidopteran life history on earth, larvae grow to 100mm, spending ∼6 years as wood-boring parasites feeding on host tree phloem. Parasite fitness is a product of host suitability.... | 25,535,954 | D000818:Animals; D017753:Ecosystem; D006790:Host-Parasite Interactions; D007814:Larva; D007915:Lepidoptera; D009520:New Zealand; D014197:Trees | International journal for parasitology | 2,015 | ||
[Spinal arteriovenous malformation fed by branches of the internal iliac artery (author's transl)]. | A 51-year-old male had lumbago and intermittent progressive gait disturbance for 2 years. Finally, he could not walk due to paraparesis. Neurological examination revealed flaccid paraparesis, dysuria, constipation and sensory disturbance below the L-4 dermatome. Myelogram showed serpiginous filling defects from sacral ... | 557,750 | D001165:Arteriovenous Malformations; D002420:Cauda Equina; D006801:Humans; D007083:Iliac Artery; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013116:Spinal Cord | No shinkei geka. Neurological surgery | 1,977 | ||
Kidney transplantation improves sleep-related breathing in hemodialysis patients. | AIMS
To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis.
METHODS
A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful ki... | 10.1159/000157373 | 18,818,490 | D000328:Adult; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D017286:Polysomnography; D011659:Pulmonary Gas Exchange; D006435:Renal Dialysis; D012891:Sleep Apnea Syndromes; D012892:Sleep Deprivation; D016896:Treatment Outcome | Blood purification | 2,008 | |
Skin metastasis in laryngeal carcinoma. | Cutaneous metastases from carcinoma of the larynx are very rare. We observed a 64-year-old Japanese patient with squamous cell carcinoma of the larynx who developed a subcutaneous nodule on the abdomen. It was found to be a metastatic tumour from the laryngeal cancer, histopathologically as well as histochemically. | 10.1111/j.1365-2230.1992.tb02169.x | 1,451,323 | D002294:Carcinoma, Squamous Cell; D006801:Humans; D007822:Laryngeal Neoplasms; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms | Clinical and experimental dermatology | 1,992 | |
Effect of ion distribution on conductivity of block copolymer electrolytes. | Energy-filtered transmission electron microscopy (EFTEM) was used to determine the distribution of lithium ions in solid polymer electrolytes for lithium batteries. The electrolytes of interest are mixtures of bis(trifluoromethane)sulfonimide lithium salt and symmetric poly(styrene-block-ethylene oxide) copolymers (SEO... | 10.1021/nl900091n | 19,193,125 | D000465:Algorithms; D002412:Cations; D004553:Electric Conductivity; D004573:Electrolytes; D007477:Ions; D008094:Lithium; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D008970:Molecular Weight; D036103:Nanotechnology; D011092:Polyethylene Glycols; D011108:Polymers | Nano letters | 2,009 | D002412:Cations; D004573:Electrolytes; D007477:Ions; D011108:Polymers; D011092:Polyethylene Glycols; D008094:Lithium |
Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model. | Increasing attention has been devoted to elucidating the mechanism of lost or decreased expression of MHC or melanoma-associated antigens (MAAs), which may lead to tumor escape from immune recognition. Loss of expression of HLA class I or MAA has, as an undisputed consequence, loss of recognition by HLA class I-restric... | 10.1002/(sici)1097-0215(19990301)80:5<781::aid-ijc24>3.0.co;2-a | 10,048,982 | D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001943:Breast Neoplasms; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005260:Female; D014644:Genetic Variation; D015234:HLA-A Antigens; D015395:Histocompatibility Antigens Class I; D006650:Histocompatibility Testing; D006801:... | International journal of cancer | 1,999 | D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000939:Epitopes; D015234:HLA-A Antigens; D015395:Histocompatibility Antigens Class I; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins |
Progression of atherosclerosis in middle-aged men: effects of multifactorial intervention. | OBJECTIVE
To determine the effect of multifactorial intervention against cardiovascular risk factors on ultrasound-determined progression of atherosclerosis in healthy middle-aged men.
DESIGN
One hundred and forty-nine healthy middle-aged men were assigned to an intervention group (IG) or a control group (CG).
SUBJ... | 10.1046/j.1365-2796.1996.476814000.x | 8,642,235 | D000328:Adult; D001161:Arteriosclerosis; D018450:Disease Progression; D006801:Humans; D006949:Hyperlipidemias; D006973:Hypertension; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D014463:Ultrasonography | Journal of internal medicine | 1,996 | |
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats. | The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergi... | 10.1358/mf.2000.22.8.802276 | 11,256,236 | D000374:Aggression; D000818:Animals; D001058:Apomorphine; D001418:Baclofen; D001522:Behavior, Animal; D004195:Disease Models, Animal; D018755:GABA Agonists; D007555:Isoxazoles; D008297:Male; D018377:Neurotransmitter Agents; D011618:Psychotic Disorders; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A; D018... | Methods and findings in experimental and clinical pharmacology | 2,000 | D018755:GABA Agonists; D007555:Isoxazoles; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D001418:Baclofen; C015542:gaboxadol; D001058:Apomorphine |
Neonatal skin: the ideal nursing interface. | Human skin holds much fascination for the average person. It is the first thing that is noticed about a person. From a neonatal perspective it is a dynamic interface with the surrounding environment and provides the surface for our nursing interventions. This article will discuss this dynamic interface and why it provi... | 10.1016/S0882-5963(98)80016-X | 9,798,366 | D006801:Humans; D007231:Infant, Newborn; D017283:Neonatal Nursing; D009742:Nursing Theory; D017592:Skin Care; D012879:Skin Physiological Phenomena | Journal of pediatric nursing | 1,998 | |
Opacification of two hydrophilic acrylic intraocular lenses 3 months after implantation. | BACKGROUND AND OBJECTIVE
To report clinical, pathologic, histochemical, ultrastructural, and spectrographic analyses of explanted hydrophilic acrylic intraocular lenses (IOLs) obtained from two patients who had early visual disturbances caused by postoperative opacification of the lens optic.
MATERIALS AND METHODS
Tw... | 12,757,092 | D000180:Acrylic Resins; D000368:Aged; D000880:Anthraquinones; D002114:Calcinosis; D002118:Calcium; D020878:Device Removal; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D008875:Middle Age... | Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye | 2,003 | D000180:Acrylic Resins; D000880:Anthraquinones; C010078:alizarin; D002118:Calcium | |
Atrial fibrillation as a cause of left ventricular dysfunction after cardiac transplantation. | We report 3 cases of late-onset atrial fibrillation several years after cardiac transplantation, each involving left ventricular systolic dysfunction in the absence of cardiac rejection or cardiac allograft vasculopathy. Although the etiology of late-onset atrial fibrillation in cardiac transplant recipients is not cle... | 10.1016/j.healun.2005.06.023 | 16,399,543 | D001281:Atrial Fibrillation; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors; D018487:Ventricular Dysfunction, Left | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation | 2,006 | |
[Tracheal diverticula]. | Tracheal diverticula (TD) are a rare congenital or acquired condition. The diagnosis of TD is based on the data of multislice spiral computed tomography and fibrotracheal bronchoscopy. DTs are most frequently located in the right, may be solitary or multiple, uni- or multilocular. Uncomplicated DTs generally have no ch... | 24,437,231 | D001999:Bronchoscopy; D003937:Diagnosis, Differential; D004240:Diverticulum; D006801:Humans; D036542:Tomography, Spiral Computed; D014133:Tracheal Diseases | Terapevticheskii arkhiv | 2,013 | ||
Effect of pesticide 1-[6-chloro-3-methyl-pyridyl-8-nitro-7-methyl-1 2 3 5 6 7-hexahydro imidazo (1,2a)]-pyridine when responding to a wheat plant's antioxidant defense system. | The purpose of this research was to establish an analytical method for analysing the 1-[6-chloro-3-methyl-pyridyl-8-nitro-7-methyl-1 2 3 5 6 7-hexahydro imidazo-(1,2a)]-pyridine (IPP) residue levels and to evaluate the difference in plant growth and its physical condition. A high performance liquid chromatography conne... | 24,176,382 | D000975:Antioxidants; D002374:Catalase; D008315:Malondialdehyde; D018384:Oxidative Stress; D009195:Peroxidase; D010544:Peroxidases; D010573:Pesticide Residues; D010940:Plant Proteins; D011725:Pyridines; D013482:Superoxide Dismutase; D014908:Triticum | Food chemistry | 2,014 | D000975:Antioxidants; D010573:Pesticide Residues; D010940:Plant Proteins; D011725:Pyridines; D008315:Malondialdehyde; D010544:Peroxidases; C121048:guaiacol peroxidase; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; C023666:pyridine | |
A novel actin mRNA splice variant regulates ACTG1 expression. | Cytoplasmic actins are abundant, ubiquitous proteins in nucleated cells. However, actin expression is regulated in a tissue- and development-specific manner. We identified a novel cytoplasmic-γ-actin (Actg1) transcript that includes a previously unidentified exon (3a). Inclusion of this exon introduces an in-frame term... | 10.1371/journal.pgen.1003743 | 24,098,136 | D000199:Actins; D017398:Alternative Splicing; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D018389:Codon, Nonsense; D003593:Cytoplasm; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D018482:Muscle, Skeletal; D020033:Protein Isoforms; D012333:RNA, Messenger | PLoS genetics | 2,013 | D000199:Actins; D018389:Codon, Nonsense; D020033:Protein Isoforms; D012333:RNA, Messenger |
The effect of hepatic impairment on the pharmacokinetics of asunaprevir, an HCV NS3 protease inhibitor. | BACKGROUND
It is necessary to evaluate the impact of hepatic impairment on the pharmacokinetic profile of direct-acting antiviral agents for the treatment of HCV infection.
METHODS
In this open-label, parallel group, multiple-dose study subjects (aged 18-70 years with a body mass index <35 kg/m(2)) with mild (n=6), m... | 10.3851/IMP2773 | 24,704,773 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents; D019540:Area Under Curve; D015992:Body Mass Index; D016022:Case-Control Studies; D004334:Drug Administration Schedule; D005260:Female; D016174:Hepacivirus; D019698:Hepatitis C, Chronic; D006801:Humans; D007546:Isoquinolines; D008099:Liver; D0082... | Antiviral therapy | 2,015 | D000998:Antiviral Agents; D007546:Isoquinolines; C084422:NS3 protein, hepatitis C virus; D011480:Protease Inhibitors; D013449:Sulfonamides; D017361:Viral Nonstructural Proteins; C571889:asunaprevir |
Resistance of Amphiphilic Polysaccharides against Marine Fouling Organisms. | Amphiphilic coatings are promising candidates for fouling-release applications. As hydrophilic components, polysaccharides are interesting and environmentally benign building blocks. We used covalently coupled alginic acid (AA) and hyaluronic acid (HA) and postmodified them with a hydrophobic fluorinated amine. The sur... | 10.1021/acs.biomac.5b01590 | 26,771,763 | D000464:Alginates; D000588:Amines; D000818:Animals; D059001:Aquatic Organisms; D018441:Biofilms; D057219:Biofouling; D002118:Calcium; D003445:Crustacea; D017377:Diatoms; D020563:Gammaproteobacteria; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006820:Hyaluronic Acid; D057927:Hydrophobic and Hydrophilic Interactio... | Biomacromolecules | 2,016 | D000464:Alginates; D000588:Amines; D006603:Hexuronic Acids; D013501:Surface-Active Agents; D020723:Glucuronic Acid; D006820:Hyaluronic Acid; D002118:Calcium |
Developmental changes in threat and self-blame for preschoolers exposed to intimate partner violence (IPV). | The presence of threat and self-blame in children exposed to violence in the home has been linked to a number of negative behavioral and emotional consequences across developmental periods. Little research, however, has examined self-reported attributions of threat and self-blame in children under the age of 6. The cur... | 10.1177/0886260513511533 | 24,368,679 | D002648:Child; D002675:Child, Preschool; D054541:Family Conflict; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012649:Self Concept; D014754:Violence | Journal of interpersonal violence | 2,014 | |
Trimazosin in chronic congestive heart failure: improved left ventricular function at rest and during exercise. | The hemodynamic effects of the oral vasodilator trimazosin were evaluated in patients with chronic congestive heart failure (CHF), initially over a 72-hour period (13 patients), and after 3 months of maintenance therapy (seven patients). During the initial evaluation, cardiac index and stroke work index increased an av... | 10.1016/0002-8703(83)90649-x | 6,139,004 | D000317:Adrenergic alpha-Antagonists; D000368:Aged; D002302:Cardiac Output; D002908:Chronic Disease; D005080:Exercise Test; D005260:Female; D006333:Heart Failure; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D011669:Pulmonary Wedge Pressure; D012146:Rest; D013318:Strok... | American heart journal | 1,983 | D000317:Adrenergic alpha-Antagonists; D010879:Piperazines; D014665:Vasodilator Agents; C005185:trimazosin |
Who should manage care? The case for providers. | Health care professionals should be the ones to make allocation decisions in the managed care setting because they are in the best position to assess outcomes, cost effectiveness, and quality of care. | 10.1353/ken.1997.0040 | 11,655,371 | D001290:Attitude; D003362:Cost-Benefit Analysis; D003657:Decision Making; D003695:Delivery of Health Care; D004467:Economics; D004651:Employment; D015276:Health Care Rationing; D006801:Humans; D007348:Insurance, Health; D008329:Managed Care Programs; D009042:Motivation; D010358:Patient Participation; D010361:Patients; ... | Kennedy Institute of Ethics journal | 1,997 | |
Limited resistance of hypertrophied skeletal muscle to glucocorticoids. | Male hypophysectomized rats were initially assigned to a control or an overloaded group that underwent compensatory hypertrophy of plantaris muscles to steady-state levels following removal of synergistic musculature. Plantaris muscle mass of overloaded animals was higher than that of controls by 38% (391 +/- 8 vs 284 ... | 10.1016/0022-4731(86)90380-8 | 3,736,045 | D000818:Animals; D003348:Cortisone; D003600:Cytosol; D004351:Drug Resistance; D005938:Glucocorticoids; D006854:Hydrocortisone; D006984:Hypertrophy; D008297:Male; D009132:Muscles; D009133:Muscular Atrophy; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid | Journal of steroid biochemistry | 1,986 | D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; C039250:triamcinolone acetonide receptor; D003348:Cortisone; D006854:Hydrocortisone |
Evaluation of an environmental health education program: assessing changes in knowledge of health professionals. | Knowledge about environmental health is crucial for nurses so they can take into account both the living and occupational environments of clients during history taking and physical assessments. When focused on local environmental conditions and exposures, outreach educational programs on environmental health can result... | 15,508,858 | D004509:Education, Nursing, Continuing; D004781:Environmental Exposure; D004782:Environmental Health; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D014903:West Virginia | AAOHN journal : official journal of the American Association of Occupational Health Nurses | 2,004 | ||
Toxoplasma gondii antibodies in common barn-owls (Tyto alba) and pigeons (Columba livia) in New Jersey. | In southwestern New Jersey during 1986 and 1987, common barn-owls and pigeons were captured on farmsteads and tested for Toxoplasma gondii antibodies by a modified direct agglutination test. In 1986, 3/28 (10.7%) adult and 0/124 nestling owls tested positive at titers of greater than or equal to 1:40. Additionally, 2/3... | 10.1016/0304-4017(90)90108-n | 2,382,386 | D000818:Animals; D000913:Antibodies, Protozoan; D001715:Bird Diseases; D001717:Birds; D010856:Columbidae; D004032:Diet; D005243:Feces; D005260:Female; D008297:Male; D009515:New Jersey; D012377:Rodentia; D014122:Toxoplasma; D014124:Toxoplasmosis, Animal | Veterinary parasitology | 1,990 | D000913:Antibodies, Protozoan |
The Role of Advanced Glycation End-Products in Cancer Disparity. | While the socioeconomic and environmental factors associated with cancer disparity have been well documented, the contribution of biological factors is an emerging field of research. Established disparity factors such as low income, poor diet, drinking alcohol, smoking, and a sedentary lifestyle may have molecular effe... | 10.1016/bs.acr.2016.08.001 | 28,052,818 | D005006:Ethnicity; D017127:Glycation End Products, Advanced; D054624:Health Status Disparities; D006801:Humans; D009369:Neoplasms | Advances in cancer research | 2,017 | D017127:Glycation End Products, Advanced |
After death 1: caring for bereaved relatives and being aware of cultural differences. | This first in a two part unit on bereavement and last offices discusses relatives' grief reactions and caring for deceased patients, taking into account spiritual and cultural differences. | 20,712,211 | D001293:Attitude to Death; D001601:Bereavement; D054521:Cultural Competency; D004645:Empathy; D005190:Family; D006801:Humans; D024802:Nurse's Role; D011368:Professional-Family Relations; D011582:Psychological Theory; D012944:Social Support; D013727:Terminal Care | Nursing times | 2,010 | ||
The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes. | Background: Adipolin, the novel adipokine that is proposed to be reduced in diabetes, obesity and inflammation, may improve glycemic control. It is known that coenzyme Q10 could improve insulin sensitivity. The aim of the current study was to investigate the effect of Q10 supplementation on adipolin concentration and g... | 10.1055/s-0042-110570 | 27,657,997 | D054392:Adipokines; D000328:Adult; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D014451:Ubiquinone | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association | 2,017 | D054392:Adipokines; C584654:C1QTNF12 protein, human; D006442:Glycated Hemoglobin A; C517652:hemoglobin A1c protein, human; D014451:Ubiquinone; C024989:coenzyme Q10 |
UCP3 Ablation Exacerbates High-Salt Induced Cardiac Hypertrophy and Cardiac Dysfunction. | BACKGROUND/AIMS
Excessive salt intake and left ventricular hypertrophy (LVH) are both critical for the development of hypertension and heart failure. The uncoupling protein 3 (UCP3) plays a cardio-protective role in early heart failure development. However, the potential role for UCP3 in salt intake and LVH is unclear.... | 10.1159/000489244 | 29,694,982 | D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly; D004452:Echocardiography; D004734:Energy Metabolism; D006321:Heart; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008928:Mitochondria; D009206:Myocardium; D012965:Sodium Chloride; D000071247:Uncoupling Protein 3 | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2,018 | D000071247:Uncoupling Protein 3; D012965:Sodium Chloride |
Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules. | BACKGROUND
Improving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherapeutic activity in cancer treatment. Considering potential clinical application in the future, it wil... | 10.1186/s12951-019-0538-3 | 31,615,570 | D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D000077143:Docetaxel; D004317:Doxorubicin; D006046:Gold; D006801:Humans; D006979:Hyperthermia, Induced; D008027:Light; D053769:Nanocapsules; D043942:Nanotubes; D010778:Photochemotherapy; D010789:Phototherapy; D000075462:Serum ... | Journal of nanobiotechnology | 2,019 | D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D000077143:Docetaxel; D006046:Gold; D004317:Doxorubicin; D000075462:Serum Albumin, Human |
Effect of residence in a fluoridated community on the incidence of coronal and root caries in an older adult population. | Eighteen-month caries incidence among older adult residents of fluoridated and nonfluoridated communities was compared. Rates for both coronal and root caries were consistently lower among long-term residents of the fluoridated communities than among life-long residents of nonfluoridated communities. Coronal caries inc... | 10.1111/j.1752-7325.1989.tb02049.x | 2,788,735 | D000368:Aged; D015331:Cohort Studies; D003731:Dental Caries; D005260:Female; D005457:Fluoridation; D005500:Follow-Up Studies; D006801:Humans; D007484:Iowa; D008297:Male; D012111:Residence Characteristics; D012307:Risk Factors; D012424:Rural Population; D013997:Time Factors; D014092:Tooth Root | Journal of public health dentistry | 1,989 | |
What information do consumers consider, and how do they look for it, when shopping for groceries online? | Previous research investigating what information shoppers seek when purchasing groceries has used either lab-experiments or observed shoppers in supermarkets. The present research investigates this question in a relatively naturalistic online-grocery environment. Forty participants completed their weekly shopping onlin... | 25,660,339 | D000328:Adult; D002755:Choice Behavior; D003258:Consumer Behavior; D005133:Eye Movements; D005260:Female; D005515:Food Labeling; D005518:Food Preferences; D015438:Health Behavior; D006293:Health Promotion; D006801:Humans; D057226:Information Seeking Behavior; D020407:Internet; D008297:Male; D008875:Middle Aged; D055815... | Appetite | 2,015 | ||
A Case of Pneumonia Caused by Pneumocystis jirovecii Resistant to Trimethoprim-Sulfamethoxazole. | A 50-year-old male visited the outpatient clinic and complained of fever, poor oral intake, and weight loss. A chest X-ray demonstrated streaky and fibrotic lesions in both lungs, and chest CT revealed multifocal peribronchial patchy ground-glass opacities with septated cystic lesions in both lungs. Cell counts in the ... | 10.3347/kjp.2015.53.3.321 | 26,174,826 | D000900:Anti-Bacterial Agents; D024881:Drug Resistance, Bacterial; D006801:Humans; D008168:Lung; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii; D011014:Pneumonia; D011859:Radiography; D013420:Sulfamethoxazole; D014295:Trimethoprim | The Korean journal of parasitology | 2,015 | D000900:Anti-Bacterial Agents; D014295:Trimethoprim; D013420:Sulfamethoxazole |
Feasibility of ANFIS-PSO and ANFIS-GA Models in Predicting Thermophysical Properties of Al2O3-MWCNT/Oil Hybrid Nanofluid. | The main purpose of the present paper is to improve the performance of the adaptive neuro-fuzzy inference system (ANFIS) in predicting the thermophysical properties of Al2O3-MWCNT/thermal oil hybrid nanofluid through mixing using metaheuristic optimization techniques. A literature survey showed that the use of an artif... | 10.3390/ma12213628 | 31,690,020 | Materials (Basel, Switzerland) | 2,019 | ||
Parents' and healthcare professionals' perceptions of the quality of care: A PITSTOP model of caring. | BACKGROUND
Quality of care is measured by various indicators. Besides objective quantifications, it is necessary to understand the meaning of quality of care from the perspectives of patients, families, and healthcare professionals.
OBJECTIVES
This study aimed to understand parents' and healthcare professionals' perc... | 10.1111/nuf.12391 | 31,583,716 | D000328:Adult; D004645:Empathy; D005260:Female; D006282:Health Personnel; D006776:Hospitals, Pediatric; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010290:Parents; D018802:Patient-Centered Care; D010465:Perception; D036301:Qualitative Research; D011787:Quality of Health Care | Nursing forum | 2,019 | |
The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes. | Elevated amounts of cholesterol are thought to be involved in several severe diseases. Despite the fact that many studies have been performed and published, the action of cholesterol-lowering agents used to diminish the plasma cholesterol level is not fully understood yet. In this study, the effects of the HMG-CoA redu... | 10.1124/dmd.111.040402 | 22,180,046 | D000924:Anticholesteremic Agents; D002478:Cells, Cultured; D002784:Cholesterol; D003600:Cytosol; D004791:Enzyme Inhibitors; D005260:Female; D005464:Fluorobenzenes; D022781:Hepatocytes; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008297:Male; D008861:Microsomes; D008875:Middle Aged; D020543:... | Drug metabolism and disposition: the biological fate of chemicals | 2,012 | D000924:Anticholesteremic Agents; C548418:CYP51A1 protein, human; D004791:Enzyme Inhibitors; D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020543:Proteome; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D002784:Cholesterol; D058886:Sterol 14-Demethylase |
A Stepwise Approach to the "Frozen Neck" for Secondary Microsurgical Reconstruction. | Supplemental Digital Content is available in the text. | 10.1097/GOX.0000000000003841 | 34,616,642 | Plastic and reconstructive surgery. Global open | 2,021 | ||
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. | Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the neurodegenerative mechanism of tau-associated pathology remains unclear, molecular elements capable of degrading and/or sequestering neurotoxic tau species may suppress neurode... | 10.1111/acel.13615 | 35,662,390 | D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles; D000071456:Sequestosome-1 Protein; D024801:Tauopathies; D016875:tau Proteins | Aging cell | 2,022 | D000071456:Sequestosome-1 Protein; C101343:Sqstm1 protein, mouse; D016875:tau Proteins |
The flowerpiercers' hook: an experimental test of an evolutionary trade-off. | The evolution of features that enhance an organism's performance in one activity can adversely affect its performance in another. We used an experimental approach to document a trade-off associated with the evolution of the long hook at the tip of the bill of birds belonging to the genus Diglossa (flowerpiercers). In D... | 10.1098/rspb.2002.2231 | 12,590,760 | D000222:Adaptation, Physiological; D000818:Animals; D001502:Beak; D005075:Biological Evolution; D004435:Eating; D005247:Feeding Behavior; D035264:Flowers; D005638:Fruit; D027741:Ipomoea; D029746:Lobelia; D019684:Magnoliopsida; D020308:Songbirds | Proceedings. Biological sciences | 2,003 | |
Prodromal symptoms and atypical affectivity as predictors of major depression in juveniles: implications for prevention. | BACKGROUND
Given the long-term morbidity of juvenile-onset major depressive disorder (MDD), it is timely to consider whether more effort should be dedicated to its primary and secondary prevention.
METHODS
We reviewed studies of prodromal symptoms that may herald a first episode pediatric MDD and considered whether t... | 10.1111/j.1469-7610.2010.02230.x | 20,202,041 | D000293:Adolescent; D000339:Affect; D002648:Child; D003865:Depressive Disorder, Major; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D008297:Male; D010913:Pituitary-Adrenal System; D011237:Predictive Value of Tests; D012307:Risk Factors | Journal of child psychology and psychiatry, and allied disciplines | 2,010 | |
A technical consideration when using flow diversion for recurrent aneurysms following stent-assisted coiling. | Flow diversion (FD) is a treatment option for recurrent aneurysms including following stent-assisted coiling (SAC), although this approach is both 'off-label' and unproven. A technical challenge of FD placement may involve the microwire catching on the tines of the previously placed stent or potentially going 'in-out-i... | 10.1136/bcr-2016-012783 | 27,852,655 | D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D057785:Catheters; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D006801:Humans; D002532:Intracranial Aneurysm; D012008:Recurrence; D015607:Stents | BMJ case reports | 2,016 | |
Spectacle non-tolerance in clinical practice - a systematic review with meta-analysis. | PURPOSE
Spectacle non-tolerance or adverse events to spectacle wear are serious concerns for both patients and practitioners. Non-tolerance may contribute to a negative impact on the practitioner's ability and practice. Therefore, a detailed understanding of frequency and causes of spectacle non-tolerance in clinical o... | 10.1111/opo.12796 | 33,751,648 | D005139:Eyeglasses; D006801:Humans; D010349:Patient Compliance; D055656:Prescriptions; D012029:Refraction, Ocular; D012030:Refractive Errors; D015351:Vision Screening; D014792:Visual Acuity | Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) | 2,021 | |
Bone Graft Options in Spinal Fusion: A Review of Current Options and the Use of Mesenchymal Cellular Bone Matrices. | BACKGROUND
Spinal fusion is the mainstay treatment for various spinal conditions ranging from lumbar and cervical stenosis to degenerative spondylolisthesis as well as extensive deformity corrections. A new emerging category of allograft is cellular bone matrices (CBMs), which take allogeneic mesenchymal stem cells and... | 10.1016/j.wneu.2021.11.130 | 34,875,392 | D000818:Animals; D001857:Bone Matrix; D018786:Bone Substitutes; D016025:Bone Transplantation; D008159:Lumbar Vertebrae; D059630:Mesenchymal Stem Cells; D012189:Retrospective Studies; D013122:Spinal Diseases; D013123:Spinal Fusion | World neurosurgery | 2,022 | D018786:Bone Substitutes |
Neighborhood-scale ambient NO2 concentrations using TROPOMI NO2 data: Applications for spatially comprehensive exposure assessment. | This study estimated long-term average ambient NO2 concentrations using TROPOspheric Monitoring Instrument (TROPOMI) tropospheric NO2 data and land use information at the spatial resolution of 500 m in California for the years 2018-2019. Our satellite-land use regression model demonstrated reasonably high predictive po... | 10.1016/j.scitotenv.2022.159342 | 36,223,808 | D009585:Nitrogen Dioxide; D000397:Air Pollution; D000393:Air Pollutants; D004784:Environmental Monitoring; D015141:Los Angeles; D052638:Particulate Matter | The Science of the total environment | 2,023 | D009585:Nitrogen Dioxide; D000393:Air Pollutants; D052638:Particulate Matter |
HVJ (Sendai virus)-cationic liposomes: a novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium. | We designed a novel technique for targeted gene transfer into the airway epithelium. This was constructed using multilamellar cationic liposomes, containing N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride, phosphatidylcholine and cholesterol and fused with haemagglutinating virus of Japan (HVJ), namely ... | 10.1038/sj.gt.3300463 | 9,282,164 | D000818:Animals; D001980:Bronchi; D002412:Cations; D003550:Cystic Fibrosis; D004848:Epithelium; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D007763:Lac Operon; D008081:Liposomes; D008156:Luciferases; D008168:Lung; D011650:Pulmonary Alveoli; D051381:Rats; D018108:Respirovirus; D01... | Gene therapy | 1,997 | D002412:Cations; D008081:Liposomes; D008156:Luciferases |
A novel process for integrating patient stories into patient education interventions: incorporating lessons from theater arts. | OBJECTIVE
Patient narratives, or stories, are an effective means of educating patients because they increase personal relevance and may reduce counter-arguing. However, such stories must seamlessly combine evidenced-based health information while being true to real patient experiences. The purpose of this paper is to d... | 10.1016/j.pec.2012.06.012 | 22,770,814 | D001741:Black or African American; D003142:Communication; D006266:Health Education; D006293:Health Promotion; D006801:Humans; D006973:Hypertension; D033262:Narration; D010353:Patient Education as Topic; D016730:Program Development; D013689:Telephone; D014743:Videotape Recording | Patient education and counseling | 2,012 | |
Indomethacin inhibits renal functional adaptation to nephron loss. | Immediately after unilateral nephrectomy, the glomerular filtration rate (GFR) and urinary excretion rate increase in the remaining transplanted rat kidney. In a previous study, we found that GFR in a transplanted kidney was reduced through an activation of the tubuloglomerular feedback control. Excision of the rat's o... | 10.1159/000172920 | 6,366,954 | D000818:Animals; D004231:Diuresis; D005246:Feedback; D005919:Glomerular Filtration Rate; D007213:Indomethacin; D007668:Kidney; D016030:Kidney Transplantation; D008297:Male; D009392:Nephrectomy; D011453:Prostaglandins; D051381:Rats; D011919:Rats, Inbred Strains; D014882:Water-Electrolyte Balance | Renal physiology | 1,984 | D011453:Prostaglandins; D007213:Indomethacin |
Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines. | The usefulness of cell lines in the study and prediction of the clinical behaviour of lung cancer is still a matter of debate. However, lung tumour cell cultures have been of value in investigations concerning molecular and cell biological aspects of these neoplasms. Especially in the examination of characteristics spe... | 10.1242/jcs.91.1.91 | 2,473,086 | D018288:Carcinoma, Small Cell; D002460:Cell Line; D006801:Humans; D015151:Immunoblotting; D007381:Intermediate Filament Proteins; D007633:Keratins; D008175:Lung Neoplasms; D008856:Microscopy, Fluorescence; D008858:Microscopy, Phase-Contrast; D014407:Tumor Cells, Cultured | Journal of cell science | 1,988 | D007381:Intermediate Filament Proteins; D007633:Keratins |
Activation of alpha(2)-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. | With the use of the microdialysis method, exercise-induced lipolysis was investigated in subcutaneous adipose tissue (SCAT) in obese subjects and compared with lean ones, and the effect of blockade of alpha(2)-adrenergic receptors (ARs) on lipolysis during exercise was explored. Changes in extracellular glycerol concen... | 10.1152/ajpregu.2000.279.2.R499 | 10,938,238 | D000273:Adipose Tissue; D000328:Adult; D004837:Epinephrine; D015444:Exercise; D005110:Extracellular Space; D005230:Fatty Acids, Nonesterified; D005990:Glycerol; D006801:Humans; D008066:Lipolysis; D008297:Male; D009638:Norepinephrine; D009765:Obesity; D009994:Osmolar Concentration; D011942:Receptors, Adrenergic, alpha; ... | American journal of physiology. Regulatory, integrative and comparative physiology | 2,000 | D005230:Fatty Acids, Nonesterified; D011942:Receptors, Adrenergic, alpha; D005990:Glycerol; D009638:Norepinephrine; D004837:Epinephrine |
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. | This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae regarding their structure, origin, species specificity, dynamics and formation will be explored. In additi... | 10.1186/1476-5926-1-1 | 12,437,787 | Comparative hepatology | 2,002 | ||
Unusual occurrence of a DAG motif in the Ipomovirus Cassava brown streak virus and implications for its vector transmission. | Cassava is the main staple food for over 800 million people globally. Its production in eastern Africa is being constrained by two devastating Ipomoviruses that cause cassava brown streak disease (CBSD); Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV), with up to 100% yield loss for sma... | 10.1371/journal.pone.0187883 | 29,155,849 | D000818:Animals; D016679:Genome, Viral; D006430:Hemiptera; D059014:High-Throughput Nucleotide Sequencing; D007303:Insect Vectors; D007630:Kenya; D002365:Manihot; D058977:Molecular Sequence Annotation; D010802:Phylogeny; D010935:Plant Diseases; D019176:Potyviridae; D014454:Uganda | PloS one | 2,017 | |
Antiproteinuric effect of blood-pressure-lowering agents: a meta-analysis of comparative trials. | Whether ACE inhibitors (ACEi) differ from other antihypertensives in their efficacy to lower proteinuria is controversial. We therefore performed a meta-analysis of articles on this subject. The secondary objective in our meta-analysis was to study whether there is any difference between diabetic and non-diabetic patie... | 8,643,149 | D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001794:Blood Pressure; D003928:Diabetic Nephropathies; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases; D011507:Proteinuria; D012044:Regression Analysis | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 1,995 | D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents | |
Which factors determine the development of late potentials after first myocardial infarction? A multifactorial analysis. | A multifactorial analysis was performed to study the factors that contributed to the occurrence of late potentials on the signal-averaged electrocardiogram in 106 consecutive patients with a first myocardial infarction. Ninety-three (88%) patients received intravenous thrombolytic therapy within 6 hours of symptom onse... | 10.1111/j.1540-8159.1991.tb02805.x | 1,721,214 | D001145:Arrhythmias, Cardiac; D003327:Coronary Disease; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D012044:Regression Analysis; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted; D015912:Thrombolytic ... | Pacing and clinical electrophysiology : PACE | 1,991 | |
Correlation of autonomic indices with thyroid status. | The autonomic status in female thyroid patients was compared with healthy, age matched normal females taken as controls. The patients (29 +/- 7 years) were categorised into two groups: hyperthyroid and hypothyroid. The valsalva manoeuvre, standing to lying ratio (S/L ratio) and immediate heart rate response to standing... | 15,255,619 | D000328:Adult; D001341:Autonomic Nervous System; D005260:Female; D006339:Heart Rate; D006801:Humans; D006980:Hyperthyroidism; D007037:Hypothyroidism; D012044:Regression Analysis; D013974:Thyroxine; D014284:Triiodothyronine; D014636:Valsalva Maneuver | Indian journal of physiology and pharmacology | 2,003 | D014284:Triiodothyronine; D013974:Thyroxine | |
Unresectable thoracic neuroblastic tumors: Changes in image-defined risk factors after chemotherapy and impact on surgical management. | PURPOSE
Neuroblastoma management in children is multimodal and depends on multiple factors, including the possibility of complete surgical resection. Image-defined risk factors (IDRFs) are used to assess the feasibility of primary surgery. We studied the changes in IDRFs after neoadjuvant chemotherapy for thoracic neur... | 10.1002/pbc.29260 | 34,302,705 | D002648:Child; D018305:Ganglioneuroblastoma; D006801:Humans; D009447:Neuroblastoma; D012189:Retrospective Studies; D012307:Risk Factors; D013899:Thoracic Neoplasms | Pediatric blood & cancer | 2,021 | |
High Neutrophil-to-Lymphocyte Ratio Facilitates Cancer Growth-Currently Marketed Drugs Tadalafil, Isotretinoin, Colchicine, and Omega-3 to Reduce It: The TICO Regimen. | This paper presents remarkably uniform data showing that higher NLR is a robust prognostic indicator of shorter overall survival across the common metastatic cancers. Myeloid derived suppressor cells, the NLRP3 inflammasome, neutrophil extracellular traps, and absolute neutrophil count tend to all be directly related t... | 10.3390/cancers14194965 | 36,230,888 | Cancers | 2,022 | ||
Immunological abnormalities in myelodysplastic syndromes. I. Serum immunoglobulins and autoantibodies. | The immunoglobulin levels and autoantibody profiles of 104 patients with primary myelodysplastic syndromes (MDS), classified according to the FAB criteria, were analysed. Eight patients, four with coexistent non-Hodgkin's lymphomas, three with chronic lymphocytic leukaemia and one with a lymphoplasmacytoma, were exclud... | 10.1111/j.1365-2141.1986.tb07504.x | 3,707,859 | D000368:Aged; D001323:Autoantibodies; D001797:Blood Protein Electrophoresis; D003298:Coombs Test; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007136:Immunoglobulins; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes | British journal of haematology | 1,986 | D001323:Autoantibodies; D007136:Immunoglobulins |
Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. | The purpose of this study was to evaluate the possible involvement of xanthine and xanthine oxidase in reperfusion injury in a low-flow, reflow model of liver perfusion. Livers were perfused at flow rates around 25% of normal for 90 min and then at normal flow rates (4 ml/g/min) for 30 min. When flow was restored to no... | 2,547,932 | D000818:Animals; D005260:Female; D019271:Hypoxanthine; D007042:Hypoxanthines; D007770:L-Lactate Dehydrogenase; D008102:Liver Circulation; D008315:Malondialdehyde; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury; D013481:Superoxides; D014527:Uric Acid; D019820:Xanthine; D014969:Xanthine Oxidase; D... | The Journal of pharmacology and experimental therapeutics | 1,989 | D007042:Hypoxanthines; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D014969:Xanthine Oxidase | |
CREB, NF-Y and MEIS1 conserved binding sites are essential to balance Myostatin promoter/enhancer activity during early myogenesis. | Myostatin (MSTN) is a strong inhibitor of skeletal muscle growth in human and other vertebrates. Its transcription is controlled by a proximal promoter/enhancer (Mstn P/E) containing a TATA box besides CREB, NF-Y, MEIS1 and FXR transcription factor binding sites (TFBSs), which are conserved throughout evolution. The ai... | 10.1007/s11033-017-4126-z | 28,956,216 | D000818:Animals; D001665:Binding Sites; D023081:CCAAT-Binding Factor; D050882:CREB-Binding Protein; D002460:Cell Line; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D024510:Muscle Development; D000075064:Myeloid Ecotropic Viral Integration Site 1 Protein; D032446:Myoblasts; D055435:Myostatin; D011401:Promot... | Molecular biology reports | 2,017 | D023081:CCAAT-Binding Factor; C525911:MSTN protein, human; D000075064:Myeloid Ecotropic Viral Integration Site 1 Protein; D055435:Myostatin; D014157:Transcription Factors; D050882:CREB-Binding Protein |
Associations of particulate matter with dementia and mild cognitive impairment in China: A multicenter cross-sectional study. | Ambient air pollution has been shown to be associated with the pathogenesis of dementia and mild cognitive impairment (MCI). However, few studies have examined these associations in well-characterized populations with low residential mobility, similar living habits, and a standardized assessment of both air pollution e... | 10.1016/j.xinn.2021.100147 | 34,557,784 | Innovation (Cambridge (Mass.)) | 2,021 | ||
Boundary violations: a culture-bound syndrome. | A backlash against the self-actualizing psychotherapy movements of the 1960s and 1970s in concert with recent concerns about professional sexual misconduct has led some forensic psychiatrists to redefine many routine components of therapy as boundary behaviors. This concern has been followed by the development of conse... | 11,592,452 | D003469:Culture; D005555:Forensic Psychiatry; D017408:Guidelines as Topic; D006801:Humans; D008318:Malpractice; D008960:Models, Psychological; D011369:Professional-Patient Relations; D011613:Psychotherapy; D012742:Sex Offenses; D012725:Sexual Behavior; D014167:Transference, Psychology; D014481:United States | The journal of the American Academy of Psychiatry and the Law | 2,001 | ||
Risk of Second Malignant Neoplasm in Familial Non-Medullary Thyroid Cancer Patients. | Introduction
Survival rates in patients with non-medullary thyroid carcinoma (NMTC) are high, increasing the possibility to develop a second malignant neoplasm (SMN). Many studies investigated the relationship between increased risk of SMN in NMTC patients treated with radioiodine, but few data are available about the ... | 10.3389/fendo.2022.845954 | 35,311,228 | D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D016609:Neoplasms, Second Primary; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms | Frontiers in endocrinology | 2,022 | D007457:Iodine Radioisotopes |
Reduced expression of the IL7Ra signaling pathway in Neuromyelitis optica. | Neuromyelitis optica (NMO) is a chronic inflammatory demyelinating autoimmune disease of the central nervous system that most commonly affects the optic nerves and spinal cord. To characterize the immunological pathways involved in NMO, whole blood RNA expression array was performed using Nanostring nCounter technology... | 10.1016/j.jneuroim.2018.08.011 | 30,248,528 | D000328:Adult; D015331:Cohort Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D053699:Interleukin-7 Receptor alpha Subunit; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets | Journal of neuroimmunology | 2,018 | D053699:Interleukin-7 Receptor alpha Subunit |
FSCS Reveals the Complexity of Lipid Domain Dynamics in the Plasma Membrane of Live Cells. | The coexistence of lipid domains with different degrees of lipid packing in the plasma membrane of mammalian cells has been postulated, but direct evidence has so far been challenging to obtain because of the small size and short lifetime of these domains in live cells. Here, we use fluorescence spectral correlation sp... | 10.1016/j.bpj.2018.04.050 | 29,925,022 | D000818:Animals; D048588:Benzoxazines; D019556:COS Cells; D002462:Cell Membrane; D002470:Cell Survival; D002522:Chlorocebus aethiops; D008563:Membrane Lipids; D000644:Quaternary Ammonium Compounds; D013050:Spectrometry, Fluorescence | Biophysical journal | 2,018 | D048588:Benzoxazines; D008563:Membrane Lipids; C000625206:NR12S compound; D000644:Quaternary Ammonium Compounds |
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase. | Using a functional high-throughput screening (HTS) and subsequent SAR studies, we have discovered a novel series of non-nucleoside dengue viral polymerase inhibitors. We report the elaboration of SAR around hit compound 1 as well as the synthesis and antiviral evaluation of 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2... | 26,774,922 | D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D003715:Dengue; D003716:Dengue Virus; D006801:Humans; D010069:Oxadiazoles; D012324:RNA-Dependent RNA Polymerase; D013876:Thiophenes; D017361:Viral Nonstructural Proteins | European journal of medicinal chemistry | 2,016 | D000998:Antiviral Agents; D010069:Oxadiazoles; D013876:Thiophenes; D017361:Viral Nonstructural Proteins; C583463:1,3,4-oxadiazole; D012324:RNA-Dependent RNA Polymerase | |
Heterozygosity predicts clutch and egg size but not plasticity in a house sparrow population with no evidence of inbreeding. | We investigated the link between heterozygosity and the reaction norm attributes of reproductive performance in female house sparrows (Passer domesticus). We collected data on clutch size, egg size, hatching success and nestling survival in 2816 nesting attempts made by 791 marked individuals over a 16-year period. Ped... | 10.1111/j.1365-294X.2011.05380.x | 22,129,307 | D000818:Animals; D052284:Clutch Size; D017753:Ecosystem; D005260:Female; D056426:Genetic Loci; D014644:Genetic Variation; D006579:Heterozygote; D007178:Inbreeding; D018895:Microsatellite Repeats; D009656:North America; D010063:Ovum; D010375:Pedigree; D011156:Population Density; D012098:Reproduction; D012641:Selection, ... | Molecular ecology | 2,012 | |
Bactericidal effect of ofloxacin alone and combined with fosfomycin or vancomycin against Staphylococcus aureus in vitro and in sera from volunteers. | The bactericidal activity of ofloxacin alone and in combination was evaluated against strains of Staphylococcus aureus by measuring MBCs, FBC indexes and by the killing curve technique. Bactericidal titres were determined in sera from volunteers given ofloxacin alone or in combination with fosfomycin or vancomycin. FBC... | 10.1093/jac/20.6.839 | 3,481,627 | D000328:Adult; D000900:Anti-Bacterial Agents; D004357:Drug Synergism; D005578:Fosfomycin; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin; D010078:Oxazines; D011897:Random Allocation; D013211:Staphylococcus aureus; D014640:Vancomycin | The Journal of antimicrobial chemotherapy | 1,987 | D000900:Anti-Bacterial Agents; D010078:Oxazines; D005578:Fosfomycin; D014640:Vancomycin; D015242:Ofloxacin |
Data-driven anisotropic finite viscoelasticity using neural ordinary differential equations. | We develop a fully data-driven model of anisotropic finite viscoelasticity using neural ordinary differential equations as building blocks. We replace the Helmholtz free energy function and the dissipation potential with data-driven functions that a priori satisfy physics-based constraints such as objectivity and the s... | 10.1016/j.cma.2023.116046 | 37,426,992 | Computer methods in applied mechanics and engineering | 2,023 |
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