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Medicare Advantage Members' Expected Out-Of-Pocket Spending For Inpatient And Skilled Nursing Facility Services. | Inpatient and skilled nursing facility (SNF) cost sharing in Medicare Advantage (MA) plans may reduce unnecessary use of these services. However, large out-of-pocket expenses potentially limit access to care and encourage beneficiaries at high risk of needing inpatient and postacute care to avoid or leave MA plans. In ... | 10.1377/hlthaff.2014.1146 | 26,056,208 | D000368:Aged; D000369:Aged, 80 and over; D017047:Cost Sharing; D005260:Female; D017048:Health Care Costs; D005102:Health Expenditures; D006760:Hospitalization; D006801:Humans; D007342:Insurance Benefits; D008297:Male; D020398:Medicare Part C; D012866:Skilled Nursing Facilities; D014481:United States | Health affairs (Project Hope) | 2,015 | |
Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy. | Introduction
Observational studies have found an increased risk of hemorrhagic transformation and worse functional outcomes in patients with higher systolic blood pressure variability (BPV). However, the time-varying behavior of BPV after endovascular thrombectomy (EVT) and its effects on functional outcome have not be... | 10.1177/23969873221106907 | 36,478,756 | European stroke journal | 2,022 | ||
The posterior tracheal band: a reflector of local superior mediastinal abnormality. | The posterior tracheal band (PTB) is a thin band of uniform width consisting primarily of the posterior tracheal wall which is observed almost constantly in a well-positioned and exposed lateral view of the chest. It is formed by two interfaces; and internal junction line between the inner tracheal wall and air in the... | 10.1259/0007-1285-48-569-352 | 1,139,089 | D001466:Barium Sulfate; D003679:Deglutition; D004931:Esophageal Achalasia; D004935:Esophageal Diseases; D004938:Esophageal Neoplasms; D006801:Humans; D008477:Mediastinal Diseases; D008479:Mediastinal Neoplasms; D008482:Mediastinum; D011859:Radiography; D014132:Trachea | The British journal of radiology | 1,975 | D001466:Barium Sulfate |
Occupational therapists' reported experiences using weighted vests with children with specific developmental disorders. | The purpose of this study was to identify specific practice patterns of a convenience sample of paediatric occupational therapists and the behavioural changes that they observe when they use weighted vests with children with developmental disorders. Although the practice of weighted vests is accepted clinically, there ... | 10.1002/oti.197 | 15,118,771 | D001288:Attention; D002648:Child; D003020:Clothing; D003625:Data Collection; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D008297:Male; D009788:Occupational Therapy; D012678:Sensation Disorders; D013647:Task Performance and Analysis; D016896:Treatment Outcome; D016474:Weight-Bearing | Occupational therapy international | 2,004 | |
Changes in health and job attitudes of case managers providing intensive services. | OBJECTIVE
The health, personal life, and attitudes of case managers providing intensive services to severely mentally ill clients were evaluated to see how the managers changed over their first 18 months on the job. The authors report here on changes on major variables related to health status and job attitudes.
METH... | 10.1176/ps.44.2.168 | 8,432,503 | D000328:Adult; D001291:Attitude of Health Personnel; D001294:Attitude to Health; D002055:Burnout, Professional; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007588:Job Satisfaction; D008297:Male; D008329:Managed Care Programs; D009518:New York; D010347:Patient Care Planning; D011369:Professional-Patient Rel... | Hospital & community psychiatry | 1,993 | |
Effect of calf and rat serum on the induction of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes by cyproterone acetate and epidermal growth factor. | Induction of hepatocyte DNA synthesis in culture by cyproterone acetate (CPA), a potent hepatomitogen in vivo, was studied. Adult rat hepatocytes were grown on collagen gels in primary culture for 3 to 10 d. Epidermal growth factor (EGF) was used as a model inducer to establish appropriate culture conditions. (a) In se... | 10.1007/BF02620920 | 2,934,366 | D000818:Animals; D000831:Animals, Newborn; D001769:Blood; D002417:Cattle; D002452:Cell Count; D002478:Cells, Cultured; D003534:Cyproterone; D017373:Cyproterone Acetate; D004261:DNA Replication; D004815:Epidermal Growth Factor; D005260:Female; D008099:Liver; D008938:Mitosis; D051381:Rats; D011919:Rats, Inbred Strains; D... | In vitro cellular & developmental biology : journal of the Tissue Culture Association | 1,985 | D017373:Cyproterone Acetate; D004815:Epidermal Growth Factor; D003534:Cyproterone |
Incorporating group-level exposure information in case-control studies with missing data on dichotomous exposures. | In case-control studies with exposure data obtained from interviews, participation is an issue of concern. Use of external group-level exposure information, available for all cases and controls (including nonparticipants), can reduce participation bias and improve precision of effect estimates. Our methodologic investi... | 10.1097/01.ede.0000129510.67536.36 | 15,232,411 | D015982:Bias; D016022:Case-Control Studies; D019352:Censuses; D003198:Computer Simulation; D006801:Humans; D007407:Interviews as Topic; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D016015:Logistic Models; D016273:Occupational Exposure; D016017:Odds Ratio; D011336:Probability; D045808:Refusal to Participat... | Epidemiology (Cambridge, Mass.) | 2,004 | |
Hip-spine syndrome: total sagittal alignment of the spine and clinical symptoms in patients with bilateral congenital hip dislocation. | STUDY DESIGN
The influence of the pathologic state of the hip joint on the total sagittal alignment of the spine was investigated in patients with congenital hip dislocation retrospectively
OBJECTIVE
The purpose of this study was to analyze the total sagittal alignment of the spine and the clinical symptoms in patien... | 10.1097/01.brs.0000143671.67779.14 | 15,507,807 | D000368:Aged; D000886:Anthropometry; D005260:Female; D006618:Hip Dislocation, Congenital; D006801:Humans; D017116:Low Back Pain; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013122:Spinal Diseases; D013131:Spine | Spine | 2,004 | |
Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein. | Malaria vaccine development has been hampered by the limited availability of antigens identified through conventional discovery approaches, and improvements are needed to enhance the efficacy of the leading vaccine candidate RTS,S that targets the circumsporozoite protein (CSP) of the infective sporozoite. Here we repo... | 10.1371/journal.pone.0159449 | 27,434,123 | D000818:Animals; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D005260:Female; D006801:Humans; D017780:Malaria Vaccines; D016778:Malaria, Falciparum; D051379:Mice; D008810:Mice, Inbred C57BL; D010963:Plasmodium falciparum; D010967:Plasmodium yoelii; D015800:Protozoan Proteins; D019444:Vaccines, DNA | PloS one | 2,016 | D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D017780:Malaria Vaccines; D015800:Protozoan Proteins; D019444:Vaccines, DNA; C041595:circumsporozoite protein, Protozoan |
[Plato psychiatrist, Foucault platonic]. | This work explores the links between the concepts of "soul", "law" and "word" in Plato's work, in order to highlight the importance and the centrality of the philosophical-therapeutic dimension in the Greek philosopher's thought. In that way, this work pretends to show that "contemporary" problems usually discussed wit... | 28,225,846 | D010684:Philosophy; D011570:Psychiatry | Vertex (Buenos Aires, Argentina) | 2,016 | ||
Effect of acute ACTH administration on plasma steroid levels in the dog. | Production of adrenal steroids in intact and castrated dogs is stimulated acutely by ACTH. While the increase in plasma cortisol, 17-hydroxypregnenolone and 17-hydroxyprogesterone is not affected by castration, the increment of dehydroepiandrosterone is totally abolished. On the other hand, administration of 17-hydroxy... | 10.1016/s0039-128x(84)80016-1 | 6,100,341 | D000311:Adrenal Glands; D000324:Adrenocorticotropic Hormone; D000728:Androgens; D000818:Animals; D002369:Castration; D003687:Dehydroepiandrosterone; D004285:Dogs; D006854:Hydrocortisone; D008297:Male; D011372:Progestins; D011467:Prostate; D013256:Steroids; D013737:Testis | Steroids | 1,984 | D000728:Androgens; D011372:Progestins; D013256:Steroids; D003687:Dehydroepiandrosterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone |
C28 Terpenoids from Lamiaceous Plant Perovskia scrophulariifolia: Their Structures and Anti-neuroinflammatory Activity. | Structurally unique C28 terpenoids, perovsfolins A (1) and B (2), were isolated from the aerial parts of an Uzbek medicinal plant, Perovskia scrophulariifolia (Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C6-C3 ester moiety were elucidated on the basis of... | 10.1021/acs.orglett.0c02855 | 32,941,043 | D000893:Anti-Inflammatory Agents; D015394:Molecular Structure; D035261:Plant Components, Aerial; D010936:Plant Extracts; D010946:Plants, Medicinal; D027544:Salvia; D013729:Terpenes | Organic letters | 2,020 | D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013729:Terpenes |
The Generalized Adaptation Account of Autism. | The heterogeneous phenomenology of autism together with diverse patterns of comorbidities led in the past to formulation of manifold theories and hypotheses on different explanatory levels. We scrutinize most recent findings from genetics, neurobiology and physiology and derive testable hypotheses about possible physio... | 10.3389/fnins.2020.534218 | 33,122,985 | Frontiers in neuroscience | 2,020 | ||
Analysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19. | OBJECTIVE
This study is to evaluate the effect of proton-pump inhibitors on the course of COVID-19.
METHODS
Clinical data of moderate COVID-19 patients admitted to the Shanghai Public Health Clinical Center for treatment from January 20, 2020, to March 16, 2020, were collected. A retrospective study was conducted and... | 10.2147/JIR.S292303 | 33,574,690 | Journal of inflammation research | 2,021 | ||
Obesity influences the microbiotic biotransformation of chlorogenic acid. | Obesity is a major public health problem. Gut microbiome dysbiosis has been associated with obesity, however, little is known on the effect of the dysbiosis on the microbiotic bio-transformation of xenobiotics. Fecal samples of lean (n = 9) and obese (n = 4) female volunteers were collected and characterized by 16 S rD... | 10.1016/j.jpba.2021.114550 | 35,124,448 | D001711:Biotransformation; D002726:Chlorogenic Acid; D064806:Dysbiosis; D005243:Feces; D005260:Female; D006801:Humans; D009765:Obesity; D006435:Renal Dialysis | Journal of pharmaceutical and biomedical analysis | 2,022 | D002726:Chlorogenic Acid |
The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors. | The kainate-type of ionotropic glutamate receptors are assembled from a combination of five different pore-forming subunits (GluK1-5), which confer distinct functional and pharmacological properties. These receptors are also modulated by co-assembly with the auxiliary subunits Neto1 and Neto2. To determine the impact o... | 26,277,340 | D004305:Dose-Response Relationship, Drug; D018683:Excitatory Amino Acid Agents; D018698:Glutamic Acid; D057809:HEK293 Cells; D006801:Humans; D008564:Membrane Potentials; D008565:Membrane Proteins; D018408:Patch-Clamp Techniques; D018092:Receptors, Kainic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinan... | Neuropharmacology | 2,015 | D018683:Excitatory Amino Acid Agents; C104517:Gluk1 kainate receptor; D008565:Membrane Proteins; C456602:NETO1 protein, human; C574595:NETO2 protein, human; D018092:Receptors, Kainic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; D018698:Glutamic Acid | |
Exotic magnetism in As-doped α/β-In2Se3 monolayers with tunable anisotropic carrier mobility. | The two-dimensional (2D) material family is expanding fast as novel metal chalcogenides are being continually fabricated and intriguingly, plenty of them are ideal candidates for future nanoscale electronic and magnetic devices. Based on first-principles calculations, we investigated the electronic and magnetic propert... | 10.1039/c9cp02746g | 31,441,491 | Physical chemistry chemical physics : PCCP | 2,019 | ||
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. | Glucocorticoids are widely used anti-inflammatory and immunomodulatory agents, of which the action mechanism is mainly based on interference of hormone-activated glucocorticoid receptor (GR) with the activity of transcription factors, such as nuclear factor-kappaB (NF-kappaB). In addition to the well described interact... | 10.1038/emboj.2008.95 | 18,511,904 | D002460:Cell Line; D016207:Cytokines; D003593:Cytoplasm; D004790:Enzyme Induction; D005786:Gene Expression Regulation; D005938:Glucocorticoids; D006657:Histones; D006801:Humans; D007249:Inflammation; D007546:Isoquinolines; D028884:Karyopherins; D008024:Ligands; D010766:Phosphorylation; D011401:Promoter Regions, Genetic... | The EMBO journal | 2,008 | D016207:Cytokines; D005938:Glucocorticoids; D006657:Histones; D007546:Isoquinolines; D028884:Karyopherins; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D011965:Receptors, Glucocorticoid; D013449:Sulfonamides; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D012694:Serine; D038744... |
Determination of organophosphorus in dairy products by graphitic carbon nitride combined molecularly imprinted microspheres with ultra performance liquid chromatography. | Organophosphorus (OPPs) residues in dairy products are a potential threat to human health. To extract trace amounts of OPPs in dairy products, a graphitic carbon nitride (g-C3N4) was synthesized and combined with OPPs-based molecularly imprinted microspheres (MIM) to create a composite material (MIM/g-C3N4). Then, the ... | 10.1016/j.fochx.2022.100424 | 36,211,753 | Food chemistry: X | 2,022 | ||
Genetic approaches to dissect plant nonhost resistance mechanisms. | Nonhost resistance (NHR) refers to the immunity of most tested genotypes of a plant species to most tested variants of a pathogen species. Thus, NHR is broad spectrum and durable in nature and constitutes a major safety barrier against invasion of a myriad of potentially pathogenic microbes in any plants including dome... | 10.1111/mpp.13290 | 36,617,319 | D060467:Disease Resistance; D001487:Basidiomycota; D005838:Genotype; D018556:Crops, Agricultural; D010935:Plant Diseases | Molecular plant pathology | 2,023 | |
Conductivity enhancement in carbon nanocone adhesive by electric field induced formation of aligned assemblies. | We show how an alternating electric field can be used to assemble carbon nanocones (CNCs) and align these assemblies into microscopic wires in a commercial two-component adhesive. The wires form continuous pathways that may electrically connect the alignment electrodes, which leads to directional conductivity (∼10(-3) ... | 10.1021/am100990c | 21,268,639 | ACS applied materials & interfaces | 2,011 | ||
Impacts of produced water origin on bacterial community structures of activated sludge. | The purpose of this study was to reveal how activated sludge communities respond to influent quality and indigenous communities by treating two produced waters from different origins in a batch reactor in succession. The community shift and compositions were investigated using Polymerase Chain Reaction-denaturing gradi... | 26,574,104 | D001419:Bacteria; D011084:Polycyclic Aromatic Hydrocarbons; D012722:Sewage; D014867:Water; D014874:Water Pollutants, Chemical; D018508:Water Purification; D060753:Water Quality | Journal of environmental sciences (China) | 2,015 | D011084:Polycyclic Aromatic Hydrocarbons; D012722:Sewage; D014874:Water Pollutants, Chemical; D014867:Water | |
Regulatory function of the novel transcription factor CxrC in Penicillium oxalicum. | Numerous transcription factors (TFs) in ascomycete fungi play crucial roles in cellular processes; however, how most of them function is poorly understood. Here, we identified and characterized a novel TF, CxrC (POX01387), acting downstream of the key TF CxrA, which is essential for plant-biomass-degrading-enzyme (PBDE... | 10.1111/mmi.14843 | 34,797,006 | D020816:Amino Acid Motifs; D002480:Cellulase; D005656:Fungal Proteins; D015966:Gene Expression Regulation, Fungal; D010407:Penicillium; D011401:Promoter Regions, Genetic; D013172:Spores, Fungal; D014157:Transcription Factors | Molecular microbiology | 2,021 | D005656:Fungal Proteins; D014157:Transcription Factors; D002480:Cellulase |
Muscle Activation during Gait in Children with Duchenne Muscular Dystrophy. | The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus fem... | 10.1371/journal.pone.0161938 | 27,622,734 | D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D002648:Child; D004576:Electromyography; D005684:Gait; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal; D020388:Muscular Dystrophy, Duchenne | PloS one | 2,016 | |
Causal effects of genetically determined blood metabolites on multiple myeloma: a Mendelian randomization study. | Previous studies have shown that metabolites play an important role in phenotypic regulation. However, the causal relationship between metabolites and multiple myeloma has not been adequately investigated. Here, we attempt to explore the causal effects of genetically determined blood metabolites on multiple myeloma. Th... | 10.1038/s41598-023-45801-0 | 37,914,749 | D006801:Humans; D055106:Genome-Wide Association Study; D057182:Mendelian Randomization Analysis; D009101:Multiple Myeloma; D015203:Reproducibility of Results; D001663:Bilirubin | Scientific reports | 2,023 | D001663:Bilirubin |
A behaviour-based coding tool for assessing supervisors' adherence and competence: Findings from a motivational interviewing implementation study. | Supervision seems to be an essential part of therapist training and thus also of implementing evidence-based practices. However, there is a shortage of valid and reliable instruments for objective assessment of supervision competence that include both global measures and frequency counts of behaviour-two essential aspe... | 10.1002/cpp.2763 | 35,727,807 | D006801:Humans; D062405:Motivational Interviewing; D015203:Reproducibility of Results; D011594:Psychometrics; D002983:Clinical Competence | Clinical psychology & psychotherapy | 2,022 | |
Postoperative delirium secondary to atropine premedication. | Anticholinergic agents used as preoperative medications have the ability to induce postanesthetic delirium reactions. We present a case of postanesthetic delirium secondary to premedication with atropine which was treated with intravenous physostigmine. This case is presented to alert the clinician to the possibility o... | 3,865,557 | D000328:Adult; D000766:Anesthesia, Dental; D001285:Atropine; D003693:Delirium; D005260:Female; D006801:Humans; D010830:Physostigmine; D011183:Postoperative Complications; D011229:Preanesthetic Medication | Anesthesia progress | 1,985 | D001285:Atropine; D010830:Physostigmine | |
TMEDA in iron-catalyzed Kumada coupling: amine adduct versus homoleptic "ate" complex formation. | The reactions of iron chlorides with mesityl Grignard reagents and tetramethylethylenediamine (TMEDA) under catalytically relevant conditions tend to yield the homoleptic "ate" complex [Fe(mes)3 ](-) (mes=mesityl) rather than adducts of the diamine, and it is this ate complex that accounts for the catalytic activity. B... | 10.1002/anie.201308395 | 24,505,000 | Angewandte Chemie (International ed. in English) | 2,014 | ||
The effect of working memory capacity limitations on the intuitive assessment of correlation: amplification, attenuation, or both? | This article challenges Yaakov Kareev's (1995a, 2000) argument regarding the positive bias of intuitive correlation estimates due to working memory capacity limitations and its adaptive value. The authors show that, under narrow window theory's primacy effect assumption, there is a considerable between-individual varia... | 10.1037/0278-7393.33.2.438 | 17,352,623 | D001288:Attention; D015982:Bias; D006801:Humans; D007206:Individuality; D019545:Intuition; D008570:Memory, Short-Term; D011594:Psychometrics; D013223:Statistics as Topic | Journal of experimental psychology. Learning, memory, and cognition | 2,007 | |
Antidyskinetic effects of risperidone on animal models of tardive dyskinesia in mice. | The effects of risperidone, an atypical neuroleptic, were investigated on two animal models of tardive dyskinesia (TD). The repeated administration of reserpine (1.0mg/kg) or haloperidol (2.0mg/kg) induces orofacial movements in mice, which are very similar to those observed in humans presenting TD. The effects of acut... | 10.1016/s0361-9230(03)00020-0 | 12,725,899 | D000284:Administration, Oral; D000818:Animals; D014150:Antipsychotic Agents; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced; D006220:Haloperidol; D008297:Male; D051379:Mice; D009043:Motor Activity; D011897:Random Allocation; D012110:Reserpine; D018967:Risperid... | Brain research bulletin | 2,003 | D014150:Antipsychotic Agents; D012110:Reserpine; D006220:Haloperidol; D018967:Risperidone |
Development and reversal of fatigue in human tibialis anterior. | The lack of easily measurable, objective physiologic indices of muscle fatigue in humans has hampered the evaluation of interventions that putatively inhibit muscle fatigue. In 6 healthy subjects, isometric fatigue of right and left tibialis anterior (TA) was produced using 180 s of intermittent electrical stimulation ... | 10.1002/mus.880161115 | 8,413,377 | D000328:Adult; D004558:Electric Stimulation; D005221:Fatigue; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D007866:Leg; D008297:Male; D009126:Muscle Relaxation; D009132:Muscles; D015203:Reproducibility of Results; D013314:Stress, Mechanical; D013997:Time Factors | Muscle & nerve | 1,993 | |
Imaging biomarkers for diagnosis and treatment response in patients with lymphedema. | Lymphedema is defined as a dysfunction of the lymphatic system producing an accumulation of lymphatic fluid in the surrounding tissue, as well as edema and fibrosis. A total of 250 million people worldwide are affected by this condition. Greater than 99% of these cases are related to a secondary cause. As there is a la... | 10.2217/bmm-2021-0487 | 35,176,878 | D015415:Biomarkers; D006801:Humans; D008209:Lymphedema; D061305:Lymphoscintigraphy | Biomarkers in medicine | 2,022 | D015415:Biomarkers |
A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile. | A genomic signature for endosporulation includes a gene coding for a protease, YabG, which in the model organism Bacillus subtilis is involved in assembly of the spore coat. We show that in the human pathogen Clostridioidesm difficile, YabG is critical for the assembly of the coat and exosporium layers of spores. YabG ... | 10.1371/journal.ppat.1011741 | 37,956,166 | D006801:Humans; D010447:Peptide Hydrolases; D016360:Clostridioides difficile; D000082682:Clostridioides; D013171:Spores, Bacterial; D014157:Transcription Factors; D010450:Endopeptidases; D001426:Bacterial Proteins; D001412:Bacillus subtilis | PLoS pathogens | 2,023 | D010447:Peptide Hydrolases; D014157:Transcription Factors; D010450:Endopeptidases; D001426:Bacterial Proteins |
Health for all: a public health vision. | The approach of a millennial passage invites public health to a review of past performance and a preview of future prospects toward assuring a healthy public. Since the 1974 Canadian Lalonde report, the best national plans for health progress have emphasized disease prevention and health promotion. WHO's multinational ... | 10.2105/ajph.81.12.1560 | 1,746,649 | D005544:Forecasting; D006287:Health Planning Guidelines; D006292:Health Priorities; D006293:Health Promotion; D006801:Humans; D007857:Leadership; D009937:Organizational Objectives; D011314:Preventive Health Services; D011635:Public Health Administration; D014481:United States | American journal of public health | 1,991 | |
[Enhanced color flow findings in small hepatocellular carcinoma]. | Features of enhanced color flow images of small hepatocellular carcinoma (HCC) were studied to elucidate their usefulness in evaluating tumor hemodynamics. Enhanced color Doppler using the contrast agent "SH/TA508" was performed on 16 patients, 13 with HCC, 1 with regenerative nodule, and 2 with hemangiomas, in whom th... | 9,577,618 | D006528:Carcinoma, Hepatocellular; D003287:Contrast Media; D006801:Humans; D008113:Liver Neoplasms; D011134:Polysaccharides; D018615:Ultrasonography, Doppler, Color | Nihon rinsho. Japanese journal of clinical medicine | 1,998 | D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508 | |
Intravoxel Incoherent Motion-Magnetic Resonance Imaging as an Early Predictor of Treatment Response to Neoadjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma. | The aim of the study was to prospectively evaluate the clinical value of intravoxel incoherent motion (IVIM)-magnetic resonance imaging (MRI) in early predicting the treatment response to neoadjuvant chemotherapy (NAC) for nasopharyngeal carcinoma (NPC). Forty-eight patients with locoregionally advanced NPC were imaged... | 10.1097/MD.0000000000000973 | 26,091,468 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents; D002277:Carcinoma; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms; D020360:Neo... | Medicine | 2,015 | D000970:Antineoplastic Agents |
Treatment of myofascial pain with a rapid laser therapy protocol compared to occlusal splint: A double-blind, randomized clinical trial. | OBJECTIVE
To compare the effect of a rapid low-level laser therapy (LLLT) protocol to Michigan occlusal splint in the treatment of myofascial pain, as well as to evaluate their impact on Oral Health-Related Quality of Life (OHRQoL).
METHODS
Thirty participants were randomly allocated into three groups: G1: occlusal s... | 10.1080/08869634.2020.1773661 | 32,491,964 | D006801:Humans; D053685:Laser Therapy; D028022:Low-Level Light Therapy; D009209:Myofascial Pain Syndromes; D017090:Occlusal Splints; D010146:Pain; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D013705:Temporomandibular Joint Disorders; D016896:Treatment Outcome | Cranio : the journal of craniomandibular practice | 2,022 | |
Three-dimensional assessment of interfractional cervical and uterine motions using daily magnetic resonance images to determine margins and timing of replanning. | PURPOSE
This study was conducted to determine the margins and timing of replanning by assessing the daily interfractional cervical and uterine motions using magnetic resonance (MR) images.
METHODS
Eleven patients with cervical cancer, who underwent intensity-modulated radiotherapy (IMRT) in 23-25 fractions, were cons... | 10.1002/acm2.14073 | 37,317,937 | D005260:Female; D006801:Humans; D002584:Cervix Uteri; D014599:Uterus; D009038:Motion; D008279:Magnetic Resonance Imaging; D002583:Uterine Cervical Neoplasms; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D011879:Radiotherapy Dosage | Journal of applied clinical medical physics | 2,023 | |
Inpatient staffing within pediatric residency programs: work hour restrictions and the evolving role of the pediatric hospitalist. | OBJECTIVE
In October 2010, the Accreditation Council for Graduate Medical Education (ACGME) mandated new standards that will further restrict resident work hours. There is growing concern surrounding the impact these restrictions will have on the staffing of inpatient services. The objective of this study was to survey... | 10.1002/jhm.952 | 22,038,872 | D003625:Data Collection; D020445:Hospitalists; D006776:Hospitals, Pediatric; D006801:Humans; D007396:Internship and Residency; D010372:Pediatrics; D010561:Personnel Staffing and Scheduling; D016526:Workload | Journal of hospital medicine | 2,012 | |
Effects of mutation and expression of PTEN gene mRNA on tumorigenesis and progression of epithelial ovarian cancer. | OBJECTIVE
To investigate the mutation and expression of tumor suppressor gene-PTEN mRNA and explore their roles in tumorigenesis and progression of ovarian cancer.
METHODS
Mutated exon 5 of PTEN gene was examined in normal ovary (n=5), ovarian cyst (n=5), ovarian borderline tumor (n=9), epithelial ovarian cancer (n=6... | 15,104,221 | D000293:Adolescent; D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid; D015536:Down-Regulation; D005091:Exons; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms; D051059:PTEN Phosph... | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih | 2,004 | D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human | |
Avulsion fractures of the anterior superior iliac spine in adolescents. | We present two cases of traumatic avulsion of the apophysis of the anterior superior iliac spine after sports activity in adolescents. Non-operative treatment resulted in excellent functional outcome for this relatively unusual fracture. | 10.1097/00005131-199608000-00014 | 8,854,325 | D000293:Adolescent; D001265:Athletic Injuries; D050723:Fractures, Bone; D006801:Humans; D007085:Ilium; D008297:Male; D010388:Pelvis | Journal of orthopaedic trauma | 1,996 | |
Operant serial feature-positive conditional discrimination with composite features and different topography responses. | In a serial feature-positive conditional discrimination procedure the properties of a target stimulus A are defined by the presence or not of a feature stimulus X preceding it. In the present experiment, composite features preceded targets associated with two different topography operant responses (right and left bar p... | 10.1590/s0100-879x2008000200011 | 18,297,194 | D000161:Acoustic Stimulation; D000818:Animals; D003216:Conditioning, Operant; D004193:Discrimination Learning; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D012055:Reinforcement Schedule | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas | 2,008 | |
Polymorphic forms of lupane triterpenoid betulonic aldehyde (betulonal). | The lupane triterpenoid betulonic aldehyde [also known as betulonal; systematic name: lup-20(29)-en-28-al-3-one, C30H46O2] is a product of betulin oxidation. Crystals were obtained from hexane [form (I)] and dimethyl sulfoxide [form (II)] solutions. Forms (I) and (II) are both orthorhombic. The molecular geometric para... | 10.1107/S2053229614017379 | 25,186,355 | D000447:Aldehydes; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D015394:Molecular Structure; D014315:Triterpenes | Acta crystallographica. Section C, Structural chemistry | 2,014 | D000447:Aldehydes; D014315:Triterpenes; C000593278:betulonal; C480546:lupane |
ESIN and K-wire fixation have similar results in pediatric both-bone diaphyseal forearm fractures. | BACKGROUND
The purpose of this study was to compare short-term radiographic and clinical results of pediatric both-bone diaphyseal forearm fractures treated with intramedullary nail fixation using titanium nails or K-wires.
METHODS
This was a prospective comparative trial. In total, 43 patients with both-bone open or... | 10.5505/tjtes.2017.85891 | 29,052,829 | D000293:Adolescent; D001864:Bone Wires; D002648:Child; D015331:Cohort Studies; D018483:Diaphyses; D005260:Female; D005543:Forearm Injuries; D005594:Fracture Fixation, Intramedullary; D006801:Humans; D008297:Male | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES | 2,017 | |
Tuberculosis in migrants to Australia: Outcomes of a national screening program. | BACKGROUND
Few low-incidence countries are on track to achieve the ambitious target of reaching TB pre-elimination by 2035. Australia is a high-income country with a low burden of TB, which is particularly concentrated in migrant populations. As part of Australia's migration program, permanent, provisional and humanita... | 10.1016/j.lanwpc.2021.100135 | 34,327,348 | The Lancet regional health. Western Pacific | 2,021 | ||
Circular RNAs in monkey muscle: age-dependent changes. | Circular RNAs (circRNAs) have been identified in numerous species, including human, mouse, nematode, and coelacanth. They are believed to function as regulators of gene expression at least in part by sponging microRNAs. Here, we describe the identification of circRNAs in monkey (Rhesus macaque) skeletal muscle. RNA seq... | 10.18632/aging.100834 | 26,546,448 | D000367:Age Factors; D000818:Animals; D008253:Macaca mulatta; D018482:Muscle, Skeletal; D012313:RNA; D000079962:RNA, Circular; D060888:Real-Time Polymerase Chain Reaction; D017423:Sequence Analysis, RNA | Aging | 2,015 | D000079962:RNA, Circular; D012313:RNA |
Age at menopause and lifetime cognition: Findings from a British birth cohort study. | OBJECTIVE
We investigated whether cognitive performance between ages 43 and 69 years was associated with timing of menopause, controlling for hormone replacement therapy, childhood cognitive ability, and sociobehavioral factors.
METHODS
We used data from 1,315 women participating in the Medical Research Council Natio... | 10.1212/WNL.0000000000005486 | 29,643,079 | D000328:Adult; D000368:Aged; D000375:Aging; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin; D003071:Cognition; D015331:Cohort Studies; D003520:Cyclophosphamide; D003561:Cytarabine; D004317:Doxorubicin; D005260:Female; D006801:Humans; D008568:Memory; D008593:Menopause; D008875:Middle Aged; D00... | Neurology | 2,018 | D003561:Cytarabine; D015376:Nimustine; D001761:Bleomycin; D004317:Doxorubicin; D003520:Cyclophosphamide |
[Significance of surgical adjuvant chemotherapy in osteosarcoma]. | The primary site of the metastasis of osteosarcoma is the lung. More than 90% of patients have died of pulmonary metastasis in one to two years. Control of osteosarcoma depend upon the prevention of its pulmonary metastasis. The introduction of chemotherapy consisting mainly of Adriamycin, high-dose methotrexate with L... | 3,496,046 | D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms; D002945:Cisplatin; D004317:Doxorubicin; D006801:Humans; D002955:Leucovorin; D008175:Lung Neoplasms; D008297:Male; D008727:Methotrexate; D012516:Osteosarcoma; D011182:Postoperative Care | Gan to kagaku ryoho. Cancer & chemotherapy | 1,987 | D004317:Doxorubicin; D002945:Cisplatin; D002955:Leucovorin; D008727:Methotrexate | |
Unilateral but not bilateral olfactory bulbectomy inhibits body weight gain in hamsters. | The relation of the olfactory bulbs and photoperiod to the regulation of body weight was studied in male golden hamsters. Animals underwent sham operation, bilateral olfactory bulbectomy, or unilateral bulbectomy. They were left on long photoperiod for 5 weeks and then were transferred to short photoperiod for 11 weeks... | 10.1016/0031-9384(92)90474-g | 1,484,874 | D000818:Animals; D002940:Circadian Rhythm; D006224:Cricetinae; D004292:Dominance, Cerebral; D004435:Eating; D008027:Light; D008297:Male; D008647:Mesocricetus; D009830:Olfactory Bulb; D012726:Sexual Behavior, Animal; D012931:Social Environment; D015430:Weight Gain | Physiology & behavior | 1,992 | |
Lipophorin-facilitated hydrocarbon uptake by oocytes in the German cockroach Blattella germanica (L.). | Large amounts of hydrocarbons accumulate during vitellogenesis in the developing basal oocytes of the German cockroach Blattella germanica (L.), and all ovarian hydrocarbons are deposited into an egg case (ootheca) during oviposition. Hydrocarbons are not synthesized by the ovaries, but are delivered by hemolymph lipop... | 10.1242/jeb.205.6.781 | 11,914,386 | D000818:Animals; D020048:Blattellidae; D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D005260:Female; D006838:Hydrocarbons; D007659:Ketones; D008074:Lipoproteins; D009865:Oocytes; D010675:Pheromones; D011422:Propionates; D014316:Tritium | The Journal of experimental biology | 2,002 | D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D006838:Hydrocarbons; D007659:Ketones; D008074:Lipoproteins; D010675:Pheromones; D011422:Propionates; C032830:lipophorin; D014316:Tritium; C011234:3,11-dimethylnonacosanone; C029658:propionic acid |
Correlation between segmental early relaxation of the left ventricular wall and coronary occlusive disease. | Fifty of 305 patients studied angiographically had segmental early relaxation phenomenon (SERP) of the anterolateral or apical left ventricular wall. Fourteen of the 50 patients had cardiac abnormality other than, or in addition to, coronary occlusive disease. Of the remaining 36 patients, 35 had significant lesions in... | 10.1016/0002-8703(75)90154-4 | 1,114,979 | D000790:Angiocardiography; D000792:Angiography; D002932:Cineangiography; D017023:Coronary Angiography; D003327:Coronary Disease; D003973:Diatrizoate; D004562:Electrocardiography; D006329:Heart Conduction System; D006352:Heart Ventricles; D006801:Humans; D009204:Myocardial Revascularization; D014182:Transplantation, Aut... | American heart journal | 1,975 | D003973:Diatrizoate |
p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. | p33/ING1s (the growth inhibitor ING1 and candidate tumor suppressor ING1) are key players in the suppressive pathways for human tumorigenesis. We analyzed their complete transcripts, primary structures, and expression. The results led us to discover two novel and related alternatively spliced transcripts encoding p24/I... | 10.1007/s100380050206 | 10,807,544 | D000328:Adult; D017398:Alternative Splicing; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D005333:Fetus; D016147:Genes, Tumor Suppressor; D006131:Growth Inhibitors; D006801:Humans; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence D... | Journal of human genetics | 2,000 | D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D006131:Growth Inhibitors; C501503:ING1 protein, human; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D011506:Proteins; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins |
Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice. | OBJECTIVE
Pancreatic acinar cell maturation is dependent on the activity of the pancreas transcription factor 1 (PTF1) complex. Induction of pancreatitis leads to MAP kinase activation and transient suppression of the acinar differentiation programme. We investigated the role of MAP kinase-interacting kinase 1 (Mnk1) i... | 10.1136/gutjnl-2013-306068 | 25,037,190 | D061354:Acinar Cells; D000681:Amylases; D000818:Animals; D002454:Cell Differentiation; D002108:Ceruletide; D049448:Cholangiopancreatography, Magnetic Resonance; D015536:Down-Regulation; D004789:Enzyme Activation; D039561:Eukaryotic Initiation Factor-4E; D018390:Gene Targeting; D018869:Heat-Shock Response; D051379:Mice;... | Gut | 2,015 | D039561:Eukaryotic Initiation Factor-4E; D014157:Transcription Factors; C062602:transcription factor PTF1; D002108:Ceruletide; D014362:Trypsinogen; C106281:Mknk1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases; D000681:Amylases |
Clinical and genetic analysis of two Chinese infants with Mabry syndrome. | OBJECTIVE
Hyperphosphatasia mental retardation syndrome (Mabry syndrome) is an autosomal recessive disorder. We aim to analyze two Chinese patients diagnosed as Mabry syndrome.
METHODS
The clinical manifestations, diagnosis and treatment were observed in two patients. Genetic analysis including PIGV and PIGO was exam... | 27,177,984 | D000015:Abnormalities, Multiple; D044466:Asian People; D001921:Brain; D015820:Cadherins; D002681:China; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability; D008297:Male; D008364:Mannosyltransferases; D008565:Membrane Proteins; D009154:Mutation; D010641:Pheno... | Brain & development | 2,016 | D015820:Cadherins; D008565:Membrane Proteins; C438605:PCDH19 protein, human; C485854:PIGO protein, human; D000091363:Protocadherins; D008364:Mannosyltransferases; C553105:PIGV protein, human | |
Approach to childhood asthma in the era of COVID-19: The official statement endorsed by the Saudi Pediatric Pulmonology Association (SPPA). | Coronaviruses are a large family of viruses that infect humans, which may result in mild symptoms similar to those of the common cold. COVID-19 is most recent subtype similar or even worse than the two previous pandemic strains which were the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East ... | 10.1016/j.ijpam.2020.07.001 | 32,838,011 | International journal of pediatrics & adolescent medicine | 2,020 | ||
Proopiomelanocorticotropin (POMC) peptides and lipoprotein lipase activity in vitro. | Effects of alpha-melanocyte-stimulating hormone (alpha-MSH), beta-melanocyte-stimulating hormone (beta-MSH), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EPH) at concentrations from 10(-9) M up to 10(-6) M on human adipose tissue lipoprotein lipase (LPL) were studied in a cell-free system. alpha-MSH and beta-MS... | 10.1016/0196-9781(95)00026-g | 7,479,301 | D000273:Adipose Tissue; D002474:Cell-Free System; D005230:Fatty Acids, Nonesterified; D006801:Humans; D008071:Lipoprotein Lipase; D008079:Lipoproteins, VLDL; D008099:Liver; D009074:Melanocyte-Stimulating Hormones; D011333:Pro-Opiomelanocortin; D011480:Protease Inhibitors; D014280:Triglycerides; D000521:alpha-MSH; D0016... | Peptides | 1,995 | D005230:Fatty Acids, Nonesterified; D008079:Lipoproteins, VLDL; D011480:Protease Inhibitors; D014280:Triglycerides; D000521:alpha-MSH; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin; D008071:Lipoprotein Lipase |
Brachygnathia superior and degenerative joint disease: a new lethal syndrome in Angus calves. | Brachygnathia superior and generalized diarthrodial degenerative joint disease were seen in 17 related, purebred Angus calves ranging in age from 2 days to 4 months. Craniometrical studies revealed decreased maxillary and palatine bone lengths and increased cranial, skull, and facial indices. Radiological evaluation of... | 10.1177/030098588702400208 | 3,576,909 | D000818:Animals; D002358:Cartilage, Articular; D002417:Cattle; D002418:Cattle Diseases; D002508:Cephalometry; D005260:Female; D006132:Growth Plate; D006651:Histocytochemistry; D007592:Joint Diseases; D008297:Male; D008437:Maxilla; D010375:Pedigree; D012886:Skull; D013577:Syndrome; D013582:Synovial Fluid | Veterinary pathology | 1,987 | |
Posterior interosseous nerve neuropathy. Clinical and electromyographical aspects. | A clinical-EMGraphic examination was carried out in 37 patients with posterior interosseous nerve neuropathy: 5 cases had a traumatic origin, 4 iatrogenic, and 28 non-traumatic. One of the non-traumatic cases had a lipoma, and another had chondroma. In the other cases, nerve entrapment at the level of the arcade of Fro... | 1,600,887 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D005542:Forearm; D006801:Humans; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes | Electromyography and clinical neurophysiology | 1,992 | ||
Signature of a conical intersection in the dissociative photoionization of formaldehyde. | The valence-shell photoionization of formaldehyde is investigated by means of combining Photo-Electron Photo-Ion COincidence (PEPICO) experiments and ab initio calculations. The formation of three ion fragments: HCO+, CO+ and H, via dissociative photoionization following excitation at 17 eV is discussed. The experiment... | 10.1039/d0cp01267j | 32,315,003 | Physical chemistry chemical physics : PCCP | 2,020 | ||
Hand morphometrics, electrodermal activity, and stone tools haptic perception. | OBJECTIVES
Tool use requires integration among sensorial, biomechanical, and cognitive factors. Taking into account the importance of tool use in human evolution, changes associated with the genus Homo are to be expected in all these three aspects. Haptics is based on both tactile and proprioceptive feedbacks, and it i... | 10.1002/ajhb.23370 | 31,837,092 | D000328:Adult; D005260:Female; D005712:Galvanic Skin Response; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013672:Technology; D055698:Touch Perception; D055815:Young Adult | American journal of human biology : the official journal of the Human Biology Council | 2,020 | |
Turnover of Phospholipids in Normal and Phosphorus-deficient Spirodela. | When (32)P(1) was supplied as a 15-minute pulse to normal Spirodela oligorrhiza plants, the first phospholipid to become fully labeled was phosphatidic acid. Phosphatidyl glycerol reached maximum labeling before the other major phospholipids. In phosphorus-deficient plants, however, phosphatidyl glycerol became labeled... | 10.1104/pp.49.5.740 | 16,658,040 | Plant physiology | 1,972 | ||
FTIR and Raman microspectroscopy of normal, benign, and malignant formalin-fixed ovarian tissues. | Ovarian cancer is the sixth most common cancer among women worldwide, and mortality rates from this cancer are higher than for other gynecological cancers. This is attributed to a lack of reliable screening methods and the inadequacy of treatment modalities for the advanced stages of the disease. FTIR and Raman spectro... | 10.1007/s00216-006-0827-1 | 17,043,798 | D014408:Biomarkers, Tumor; D005240:Feasibility Studies; D005260:Female; D005404:Fixatives; D005557:Formaldehyde; D006801:Humans; D008853:Microscopy; D009363:Neoplasm Proteins; D010051:Ovarian Neoplasms; D012016:Reference Values; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman | Analytical and bioanalytical chemistry | 2,007 | D014408:Biomarkers, Tumor; D005404:Fixatives; D009363:Neoplasm Proteins; D005557:Formaldehyde |
Spatial and Temporal Control of Cavitation Allows High In Vitro Transfection Efficiency in the Absence of Transfection Reagents or Contrast Agents. | Sonoporation using low-frequency high-pressure ultrasound (US) is a non-viral approach for in vitro and in vivo gene delivery. In this study, we developed a new sonoporation device designed for spatial and temporal control of ultrasound cavitation. The regulation system incorporated in the device allowed a real-time co... | 10.1371/journal.pone.0134247 | 26,274,324 | D045744:Cell Line, Tumor; D002470:Cell Survival; D018014:Gene Transfer Techniques; D018922:HL-60 Cells; D006801:Humans; D066298:In Vitro Techniques; D019169:Jurkat Cells; D007938:Leukemia; D008223:Lymphoma; D013010:Sonication; D014162:Transfection; D014465:Ultrasonics; D014463:Ultrasonography | PloS one | 2,015 | |
Response timing constraints on the cortical representation of sound time structure. | The precision of spike response timing of 94 primary auditory cortex neurons was studied using conventional extracellular recording techniques in barbiturate-anesthetized cats to which tone- and/or noise-burst stimuli were presented using sealed sound delivery systems. Precision of spike timing was indexed using the st... | 10.1121/1.399718 | 2,229,675 | D000818:Animals; D001143:Arousal; D001303:Auditory Cortex; D002415:Cats; D005072:Evoked Potentials, Auditory; D008144:Loudness Perception; D009474:Neurons; D010897:Pitch Discrimination; D011930:Reaction Time | The Journal of the Acoustical Society of America | 1,990 | |
A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? | The prevalence of a number of clinical features occurring in patients with early- (before age 65) and late-onset primary degenerative dementia of the Alzheimer type (PDDAT) are compared. The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-han... | 10.1001/archneur.1983.04050030037006 | 6,830,452 | D000368:Aged; D003704:Dementia; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral; D007839:Functional Laterality; D006801:Humans; D007806:Language Disorders | Archives of neurology | 1,983 | |
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. | BACKGROUND
Single measurements of left ventricular filling pressure at rest lack sensitivity for identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on exertion. We hypothesized that exercise hemodynamic measurements (ie, changes in pulmonary capillary wedge pressure [PCWP] index... | 10.1161/CIRCHEARTFAILURE.117.004750 | 29,695,381 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization; D002302:Cardiac Output; D015444:Exercise; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure; D006801:Humans; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D016277:Ventri... | Circulation. Heart failure | 2,018 | |
[Change of Symptom Severity and Functioning According to ICF in the In-Patient Psychosomatic Rehabilitation]. | BACKGROUND
In this naturalistic study the changes of patients of an in-patient psychosomatic rehabilitation with regard to functioning and to symptom severity were examined.
METHODS
Self-evaluations of patients concerning their functioning (ICF AT-50 Psych) and their symptom severity (GSI) were elevated at 3 measurem... | 10.1055/s-0043-124308 | 29,359,284 | D000203:Activities of Daily Living; D005858:Germany; D006801:Humans; D007297:Inpatients; D010351:Patient Discharge; D011602:Psychophysiologic Disorders; D012647:Self-Assessment; D016896:Treatment Outcome | Die Rehabilitation | 2,019 | |
Ruthenium Catalyzed Rearrangement of Ene-cyclopropenes. Divergent Reaction Pathways. | The reaction of ene-cyclopropenes with Cp*RuCl(cod) leads to alkenyl bicyclo[3.1.0]hexanes, bicyclo[4.1.0]heptanes, and bicyclo[5.1.0]octanes. This reaction involves a reverse regioselectivity in the cyclopropene opening than with gold chlorides. With gem-disubstituted cyclopropenes, a novel cycloisomerization based on... | 10.1021/acs.joc.8b02849 | 30,588,814 | The Journal of organic chemistry | 2,019 | ||
Inhibition of sugar active transport across rat intestine in vivo by cadmium. | Galactose absorption by rat jejunum perfused in vivo is inhibited by 0.5 mM Cd2+. This effect is explained by impairment of the phlorizin-sensitive sugar transport system, as Cd does not modify the absorption of L-sorbose or that of galactose in the presence of 0.5 mM phlorizin. Cd inhibition is observed as early as in... | 3,616,111 | D000818:Animals; D001693:Biological Transport, Active; D002104:Cadmium; D050260:Carbohydrate Metabolism; D005260:Female; D005690:Galactose; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013013:Sorbose | Revista espanola de fisiologia | 1,987 | D002104:Cadmium; D013013:Sorbose; D005690:Galactose | |
Interpretable and Predictive Deep Neural Network Modeling of the SARS-CoV-2 Spike Protein Sequence to Predict COVID-19 Disease Severity. | Through the COVID-19 pandemic, SARS-CoV-2 has gained and lost multiple mutations in novel or unexpected combinations. Predicting how complex mutations affect COVID-19 disease severity is critical in planning public health responses as the virus continues to evolve. This paper presents a novel computational framework to... | 10.3390/biology11121786 | 36,552,295 | Biology | 2,022 | ||
Perceptions of oral health promotion in primary schools among health and education officials, community leaders, policy makers, teachers, and parents in Gulu district, northern Uganda: A qualitative study. | INTRODUCTION
One in every two cases of caries in deciduous teeth occurs in low- and middle-income countries (LMICs). The aim of the World Health Organisation's (WHO) Healthy Schools Program is to improve the oral health of children. This study explored perceptions of implementation of the Ugandan oral health schools' p... | 10.1371/journal.pone.0293761 | 37,917,631 | D002648:Child; D006801:Humans; D006293:Health Promotion; D009909:Oral Health; D014454:Uganda; D012574:Schools; D010290:Parents; D000288:Administrative Personnel | PloS one | 2,023 | |
A phase II study of localized prostate cancer treated to 75.6 Gy with 3D conformal radiotherapy. | BACKGROUND AND PURPOSE
To prospectively evaluate toxicity, biochemical failure-free survival (bFFS) and biopsy-proven local control for prostate cancer patients treated with 75.6 Gy in 42 fractions using 6-field conformal radiotherapy to prostate alone.
PATIENTS AND METHODS
From 1997 to 1999, 140 patients with T1-2Nx... | 10.1016/j.radonc.2005.06.002 | 15,990,187 | D000230:Adenocarcinoma; D000368:Aged; D001706:Biopsy; D018572:Disease-Free Survival; D006801:Humans; D007422:Intestines; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal; D015996:Survival Rate; D001743:Urinary Bladder | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | 2,005 | |
Baseline Characteristics and Predictive Factors of Intravenous Immunoglobulin Response in Drug and Device Refractory Gastroparesis Symptoms. | INTRODUCTION
Intravenous immunoglobulin (IVIG) has been shown in a small pilot series to be helpful for some patients with gastroparesis that is refractory to drugs, devices, and surgical therapies. Many but not all patients have serologic neuromuscular markers. We hypothesize that those patients with serologic markers... | 10.1097/MCG.0000000000001655 | 34,974,494 | D006801:Humans; D018589:Gastroparesis; D016756:Immunoglobulins, Intravenous; D004364:Pharmaceutical Preparations; D005968:Glutamate Decarboxylase; D011708:Pylorus; D016896:Treatment Outcome | Journal of clinical gastroenterology | 2,023 | D016756:Immunoglobulins, Intravenous; D004364:Pharmaceutical Preparations; D005968:Glutamate Decarboxylase |
Double-contrast arthrotomography of the shoulder: correlation of radiological and surgical findings in complete rotator cuff tears. | Double-contrast arthrotomography of the shoulder appears extremely valuable; we have verified its accuracy in measurements of complete rotator cuff tears. The first 31 patients so investigated and explored surgically have been retrospectively evaluated. Accurate measurements were found in 85% of the coronal diameters a... | 4,044,611 | D006801:Humans; D009132:Muscles; D012189:Retrospective Studies; D012421:Rupture; D000070599:Shoulder Injuries; D012785:Shoulder Joint; D013710:Tendons; D014056:Tomography, X-Ray | Journal of the Canadian Association of Radiologists | 1,985 | ||
Growth performance and metabolic utilization of diets including starch, dextrin, maltose or glucose as carbohydrate source by gilthead sea bream (Sparus aurata) juveniles. | The effect of dietary carbohydrate complexity on growth, feed utilization and activity of selected key liver enzymes of intermediary metabolism were studied in gilthead sea bream juveniles. Four isonitrogenous (50% crude protein) and isolipidic (16% crude lipids) diets were formulated to contain 20% of pregelatinized m... | 10.1007/s10695-009-9366-y | 19,894,133 | D000818:Animals; D017756:Aquaculture; D003912:Dextrins; D004040:Dietary Carbohydrates; D005941:Glucokinase; D005947:Glucose; D006003:Glycogen; D008099:Liver; D008320:Maltose; D011770:Pyruvate Kinase; D021541:Sea Bream; D013213:Starch | Fish physiology and biochemistry | 2,010 | D003912:Dextrins; D004040:Dietary Carbohydrates; D008320:Maltose; D013213:Starch; D006003:Glycogen; D005941:Glucokinase; D011770:Pyruvate Kinase; D005947:Glucose |
Alcohol consumption and atherosclerosis: what is the relation? Prospective results from the Bruneck Study. | BACKGROUND AND PURPOSE
Potential effects of regular alcohol consumption on atherogenesis are still controversial mainly due to the lack of prospective population-based studies.
METHODS
The Bruneck Study is a prospective population-based survey of atherosclerosis and its risk factors. The study population comprises a ... | 10.1161/01.str.29.5.900 | 9,596,232 | D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000990:Antithrombin III; D016632:Apolipoprotein A-I; D001161:Arteriosclerosis; D001515:Beer; D001794:Blood Pressure; D002340:Carotid Artery Diseases; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D0039... | Stroke | 1,998 | D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D000431:Ethanol; D000990:Antithrombin III; D005723:gamma-Glutamyltransferase |
Confined carburization-engineered synthesis of ultrathin nickel oxide/nickel heterostructured nanosheets for enhanced oxygen evolution reaction. | Low-cost and highly effective transition metal oxides are being widely researched as one of the most promising electrocatalysts for the oxygen evolution reaction (OER). However, traditional transition metal oxides suffer from sluggish reaction kinetics due to their intrinsically poor electronic conductivity. Herein, we... | 10.1039/c9nr07986f | 31,746,907 | Nanoscale | 2,019 | ||
Hyperbaric oxygen and ovarian follicular stimulation for in vitro fertilization: a pilot study. | Our objective was to assess the safety and tolerability of hyperbaric oxygen therapy (HBO) as an adjunct to IVF therapy in women with a poor prognosis for pregnancy in a prospective observational pilot study. We conclude that HBO is well tolerated by women undergoing IVF treatment and that further study is required to ... | 10.1016/j.fertnstert.2004.05.101 | 15,652,917 | D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone; D015571:Follicular Fluid; D006801:Humans; D006931:Hyperbaric Oxygenation; D010865:Pilot Projects; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A | Fertility and sterility | 2,005 | D042461:Vascular Endothelial Growth Factor A; D005640:Follicle Stimulating Hormone |
Amplification of doxorubicin mutagenicity by cupric ion. | There is a presumption that copper and anthracycline drugs will interact with DNA to produce genotoxicity. This is of concern because serum copper levels are increased in certain neoplastic diseases. To test the interaction, it was determined if the metal ion could alter the mutagenesis of doxorubicin and related drugs... | 10.1016/0041-008x(92)90144-h | 1,529,453 | D003300:Copper; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin; D004357:Drug Synergism; D006863:Hydrogen-Ion Concentration; D009152:Mutagenicity Tests; D009153:Mutagens; D012475:Salmonella; D013056:Spectrophotometry, Ultraviolet | Toxicology and applied pharmacology | 1,992 | D009153:Mutagens; D003300:Copper; D004317:Doxorubicin |
The role of prolactin in the prostatic inflammatory response to neonatal estrogen. | Estrogen exposure in the neonatal rat has been shown to disrupt the normal morphology and development of the prostate gland. The response to this exposure is manifest in adulthood as epithelial dysplasia and chronic inflammation. This inflammatory response consists of infiltrating T-lymphocytes and macrophages, which i... | 10.1210/en.2002-0038 | 12,697,713 | D000818:Animals; D000831:Animals, Newborn; D001971:Bromocriptine; D018491:Dopamine Agonists; D004334:Drug Administration Schedule; D004958:Estradiol; D005260:Female; D006728:Hormones; D007150:Immunohistochemistry; D008297:Male; D009929:Organ Size; D011388:Prolactin; D011467:Prostate; D011472:Prostatitis; D051381:Rats; ... | Endocrinology | 2,003 | D018491:Dopamine Agonists; D006728:Hormones; D001971:Bromocriptine; D004958:Estradiol; D011388:Prolactin |
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization. | PDZK1 is a four-PDZ domain-containing scaffold protein that, via its first PDZ domain (PDZ1), binds to the C terminus of the high density lipoprotein (HDL) receptor scavenger receptor, class B, type I (SR-BI). Abolishing PDZK1 expression in PDZK1 knock-out (KO) mice leads to a post-transcriptional, tissue-specific decr... | 10.1074/jbc.M800029200 | 18,544,532 | D000818:Animals; D002784:Cholesterol; D005786:Gene Expression Regulation; D006031:Glycosylation; D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D054731:PDZ Domains; D051122:Scavenger Receptors, Class B | The Journal of biological chemistry | 2,008 | D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; C514896:PDZK1 protein, mouse; D051122:Scavenger Receptors, Class B; C030104:lipoprotein cholesterol; D002784:Cholesterol |
Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits. | The involvement of tumor necrosis factor (TNF) in sleep regulation was investigated by blocking TNF using a synthetic TNF receptor fragment (TNFRF) in rabbits. Intracerebroventricular injection of 50 micrograms TNFRF decreased spontaneous non-rapid-eye-movement (NREM) sleep across the 21 h recording period. After 6 h o... | 10.1097/00001756-199601310-00063 | 8,730,848 | D000595:Amino Acid Sequence; D000818:Animals; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D017286:Polysomnography; D011817:Rabbits; D018124:Receptors, Tumor Necrosis Factor; D012890:Sleep; D012892:Sleep Deprivation; D014409:Tumor Necrosis Factor-alpha | Neuroreport | 1,996 | D010446:Peptide Fragments; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; C101675:tumor necrosis factor receptor fragment (159-178) |
Umbrella sampling simulations of biotin carboxylase: is a structure with an open ATP grasp domain stable in solution? | Biotin carboxylase is a homodimer that utilizes ATP to carboxylate biotin. Studies of the enzyme using X-ray crystallography revealed a prominent conformational change upon binding ATP. To determine the importance of this closing motion, the potential of mean force with the closure angle as a reaction coordinate was ca... | 10.1021/jp810650q | 19,585,972 | D000255:Adenosine Triphosphate; D019731:Carbon-Nitrogen Ligases; D004795:Enzyme Stability; D004926:Escherichia coli; D008958:Models, Molecular; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D012996:Solutions | The journal of physical chemistry. B | 2,009 | D012996:Solutions; D000255:Adenosine Triphosphate; D019731:Carbon-Nitrogen Ligases; C019791:biotin carboxylase |
H(+)-glycyl-L-proline cotransport in brush-border membrane vesicles of eel (Anguilla anguilla) intestine. | A plasma membrane H(+)-glycyl-L-proline (Gly-L-Pro) cotransport mechanism has been identified in isolated eel intestinal brush-border membrane vesicles (BBMV) by both measuring radiolabeled Gly-L-Pro uptake and monitoring Gly-L-Pro-dependent H+ influx with the pH-sensitive dye acridine orange. The application of an ins... | 10.1152/ajpregu.1997.272.1.R217 | 9,039,012 | D000811:Anguilla; D000818:Animals; D001692:Biological Transport; D004151:Dipeptides; D005453:Fluorescence; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa; D007422:Intestines; D007700:Kinetics; D008564:Membrane Potentials; D008871:Microvilli; D013379:Substrate Specificity | The American journal of physiology | 1,997 | D004151:Dipeptides; C015248:glycylproline; D006859:Hydrogen |
Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron. | We constructed a translational fusion between the Saccharomyces cerevisiae actin gene and the Escherichia coli beta-galactosidase structural gene such that expression of beta-galactosidase activity required accurate splicing of the actin intron. Using this chimeric gene, we generated a series of internal deletions whic... | 10.1128/mcb.6.5.1571-1578.1986 | 3,023,896 | D000199:Actins; D001483:Base Sequence; D002872:Chromosome Deletion; D004262:DNA Restriction Enzymes; D004926:Escherichia coli; D005796:Genes; D005798:Genes, Bacterial; D005800:Genes, Fungal; D010957:Plasmids; D014176:Protein Biosynthesis; D012326:RNA Splicing; D012441:Saccharomyces cerevisiae; D001616:beta-Galactosidas... | Molecular and cellular biology | 1,986 | D000199:Actins; D004262:DNA Restriction Enzymes; D001616:beta-Galactosidase |
[Radio-histological correlation of ACR4 microcalcifications in breast lesions: about 181 cases and literature review]. | The Bi-RADS (Breast Imaging Reporting and Data System) classification developed by the ACR (American College of Radiology) is the classification system for radiological images recommended for breast cancer screening. The ACR 4 microcalcification is an indeterminate or suspected abnormality with 2-95% probability of mal... | 10.11604/pamj.2018.29.140.13699 | 30,050,604 | D000232:Adenofibroma; D000293:Adolescent; D000328:Adult; D000368:Aged; D001941:Breast Diseases; D001943:Breast Neoplasms; D002114:Calcinosis; D002285:Carcinoma, Intraductal, Noninfiltrating; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009018:Morocco; D011... | The Pan African medical journal | 2,018 | |
Protein dynamics in thylakoids of the desiccation-tolerant plant Boea hygroscopica during dehydration and rehydration. | Plants of Boea hygroscopica F. Muell were dehydrated to 9% relative water content (RWC) by withholding water for 26 d, and afterward the plants were rehydrated. Leaves were taken from control plants after 7, 12, and 26 d from the beginning of dehydration, and after 6 and 48 h from rehydration. The RWC decreased by 80% ... | 10.1104/pp.124.3.1427 | 11,080,317 | D000975:Antioxidants; D002734:Chlorophyll; D003890:Desiccation; D004578:Electron Spin Resonance Spectroscopy; D007425:Intracellular Membranes; D008563:Membrane Lipids; D008565:Membrane Proteins; D008854:Microscopy, Electron; D010944:Plants; D020524:Thylakoids | Plant physiology | 2,000 | D000975:Antioxidants; D008563:Membrane Lipids; D008565:Membrane Proteins; D002734:Chlorophyll |
Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. | Acute blockade of dopamine D(2) receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. In the dorsolateral striatum, the levels of mRNA for the immediate-early gene c-fos and the neuropeptide gene neurotensin/neuromedin N (NT/N) are significantly increased... | 10,525,068 | D000818:Animals; D001345:Autoradiography; D002375:Catalepsy; D016291:Dizocilpine Maleate; D018492:Dopamine Antagonists; D004347:Drug Interactions; D016762:Genes, fos; D006220:Haloperidol; D017403:In Situ Hybridization; D008297:Male; D018696:Neuroprotective Agents; D009496:Neurotensin; D051381:Rats; D017207:Rats, Spragu... | The Journal of pharmacology and experimental therapeutics | 1,999 | D018492:Dopamine Antagonists; D018696:Neuroprotective Agents; D018004:Receptors, Bombesin; D016194:Receptors, N-Methyl-D-Aspartate; D018028:Receptors, Neurotensin; D018047:Receptors, Purinergic P1; D009496:Neurotensin; D016291:Dizocilpine Maleate; D006220:Haloperidol | |
Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma. | Bradykinin (BK) has been identified as a mediator in human bronchial asthma. The current phase II study was designed as a multicentered, double blinded, randomized, placebo-controlled, parallel-group pilot study to investigate the efficacy of the B2 BK receptor antagonist Icatibant in adult patients with chronic asthma... | 10.1016/0162-3109(96)00065-3 | 8,856,156 | D000328:Adult; D001249:Asthma; D001920:Bradykinin; D065168:Bradykinin Receptor Antagonists; D001993:Bronchodilator Agents; D004311:Double-Blind Method; D004361:Drug Tolerance; D006801:Humans; D043782:Receptor, Bradykinin B2; D012129:Respiratory Function Tests | Immunopharmacology | 1,996 | D065168:Bradykinin Receptor Antagonists; D001993:Bronchodilator Agents; D043782:Receptor, Bradykinin B2; C065679:icatibant; D001920:Bradykinin |
Impact of Enzyme Replacement Therapy and Hematopoietic Stem Cell Therapy on Growth in Patients with Hunter Syndrome. | Patients with Hunter syndrome (mucopolysaccharidosis II) present with skeletal dysplasia including short stature as well as CNS and visceral organ involvement. A previous study on Hunter syndrome indicated an impact on brain and heart involvement after hematopoietic stem cell therapy (HSCT) at an early stage but little... | 10.1016/j.ymgmr.2014.04.001 | 25,061,571 | Molecular genetics and metabolism reports | 2,014 | ||
Succinate dehydrogenase mutant of Listonella anguillarum protects rainbow trout against vibriosis. | Listonella anguillarum is a Gram-negative facultative anaerobic rod causing hemorrhagic septicemia in marine and rarely in freshwater fish. Succinate dehydrogenase (SDH) plays an important role in the tricarboxylic acid (TCA) cycle by oxidizing succinate to fumarate while reducing ubiquinone to ubiquinol. Recent studie... | 10.1016/j.vaccine.2015.09.003 | 26,382,599 | D000818:Animals; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D005393:Fish Diseases; D007506:Iron-Sulfur Proteins; D053526:Listonella; D017686:Oncorhynchus mykiss; D017384:Sequence Deletion; D013385:Succinate Dehydrogenase; D014613:Vaccines, Attenuated; D014735:Vibrio Infections; D014774:Virulence | Vaccine | 2,015 | D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D007506:Iron-Sulfur Proteins; D014613:Vaccines, Attenuated; D013385:Succinate Dehydrogenase |
Prevalence of heterotopic ossification following total disc replacement. A prospective, randomized study of two hundred and seventy-six patients. | BACKGROUND
Despite reports of good clinical outcomes in patients treated with lumbar and cervical disc replacements, varying degrees of heterotopic bone have been observed around these devices. The purposes of the present study were to determine the prevalence of heterotopic ossification following lumbar disc replaceme... | 10.2106/JBJS.F.00432 | 17,200,314 | D004185:Disability Evaluation; D006801:Humans; D007403:Intervertebral Disc; D007405:Intervertebral Disc Displacement; D008159:Lumbar Vertebrae; D009999:Ossification, Heterotopic; D011183:Postoperative Complications; D011446:Prospective Studies; D011859:Radiography; D016059:Range of Motion, Articular; D016896:Treatment ... | The Journal of bone and joint surgery. American volume | 2,007 | |
Diagnostic accuracy of Somaticell, California Mastitis Test, and microbiological examination of composite milk to detect Streptococcus agalactiae intramammary infections. | The objectives of this study were to estimate the accuracy of Somaticell (Idexx Laboratories Inc., Westbrook, ME), California Mastitis Test (CMT), and microbiological examination of composite milk (MEC) to diagnose Streptococcus agalactiae intramammary infections (IMI), and to assess the agreement between Somaticell an... | 10.3168/jds.2018-14753 | 30,146,291 | D000818:Animals; D001499:Bayes Theorem; D002140:California; D002417:Cattle; D000072480:Farms; D005260:Female; D007774:Lactation; D008414:Mastitis, Bovine; D008892:Milk; D015995:Prevalence; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections; D013292:Streptococcus agalactiae | Journal of dairy science | 2,018 | |
The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | The existence of depression in children and adolescents is well established, but debate remains about the phenomenology of the depressive syndrome in the young. In order to discover possible age differences in rates and etiology, the definition and measurement of depression must be comparable across the ages to be stud... | 10.1007/BF01537606 | 24,265,004 | Journal of youth and adolescence | 1,991 | ||
Implications of micro-RNA profiling for cancer diagnosis. | Micro-RNAs (miRNAs) are a large class of small non-coding RNAs that regulate protein expression in eucaryotic cells. Initially believed to be unique to the nematode Caenorhabditis elegans, miRNAs are now recognized to be important gene regulatory elements in multicellular organisms and have been implicated in a variety... | 10.1038/sj.onc.1209914 | 17,028,602 | D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms; D020411:Oligonucleotide Array Sequence Analysis | Oncogene | 2,006 | D035683:MicroRNAs |
Urotensin II exerts antiapoptotic effect on NRK-52E cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and Akt activation. | Urotensin II (UII) is a cyclic vasoactive peptide which is mainly expressed in kidneys. Although elevated plasma UII levels are associated with renal impairment, the influence of UII on renal injury is unclear. In this study, we monitored the influence of UII on gentamicin-induced apoptosis in rat tubular cells (NRK-52... | 23,933,501 | D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D004789:Enzyme Activation; D011464:Epoprostenol; D007686:Kidney Tubules, Distal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D047493:PPAR alpha; D051057:Proto-Oncogene Proteins c-akt; D051381:Rats; D043562:Receptors, G-Protein-Coupled; D015398:Signal T... | Molecular and cellular endocrinology | 2,013 | D047493:PPAR alpha; D043562:Receptors, G-Protein-Coupled; D014579:Urotensins; C512325:urotensin II receptor, mouse; C029677:urotensin II; D011464:Epoprostenol; D051057:Proto-Oncogene Proteins c-akt | |
Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. | Increased excitability of motor neurons in patients with amyotrophic lateral sclerosis (ALS) may be a relevant factor leading to motor neuron damage. This randomized, double-blind, three-way crossover, placebo-controlled study evaluated peripheral motor nerve excitability testing as a biomarker of hyperexcitability and... | 10.1002/cpt.1096 | 29,672,831 | D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis; D001369:Axons; D002219:Carbamates; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004576:Electromyography; D019054:Evoked Potentials, Motor; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D006801:Humans; D008297:Male; D008875:Mid... | Clinical pharmacology and therapeutics | 2,018 | D002219:Carbamates; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D010655:Phenylenediamines; C101866:ezogabine; D019782:Riluzole |
Inflammation as a Mediator of Microbiome Dysbiosis-Associated DNA Methylation Changes in Gastric Premalignant Lesions. | Evidence for the influence of chronic inflammation induced by microbial dysbiosis on aberrant DNA methylation supports a plausible connexion between disordered microbiota and precancerous lesions of gastric cancer (PLGC). Here, a comprehensive study including multi-omics data was performed to estimate the relationships... | 10.1007/s43657-023-00118-w | 37,881,317 | Phenomics (Cham, Switzerland) | 2,023 | ||
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. | Tribbles pseudokinase 3 (TRIB3) is a member of the mammalian pseudokinase tribbles family and is involved in multiple biological processes. However, the role of TRIB3 in renal cell carcinoma (RCC) remains unclear. In this study, we aimed to elucidate the biological functions of TRIB3 in RCC and explore its underlying m... | 10.7150/ijbs.29737 | 30,745,845 | D000818:Animals; D015153:Blotting, Western; D002292:Carcinoma, Renal Cell; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D008807:Mice, Inbred BALB C; D017346:Protein Se... | International journal of biological sciences | 2,019 | D018797:Cell Cycle Proteins; D012097:Repressor Proteins; C474830:TRB3 protein, mouse; C474831:TRIB3 protein, human; D017346:Protein Serine-Threonine Kinases |
Enhancement of hydrocarbons and phenols in catalytic pyrolysis bio-oil by employing aluminum hydroxide nanoparticle based spent adsorbent derived catalysts. | The present study investigated the effects of metal loaded spent adsorbent as catalyst for the catalytic pyrolysis of pine needle biomass. Metal active sites (Ni, Fe, Cu, Zn and Mo) were introduced in alumina matrix by wet impregnation process. Non-catalytic and catalytic semi-batch pyrolysis study was carried out at c... | 10.1016/j.chemosphere.2021.132220 | 34,543,895 | D000536:Aluminum Hydroxide; D056804:Biofuels; D018533:Biomass; D002384:Catalysis; D006358:Hot Temperature; D006838:Hydrocarbons; D053758:Nanoparticles; D010636:Phenols; D010938:Plant Oils; D059808:Polyphenols; D000077319:Pyrolysis | Chemosphere | 2,022 | C000613328:Bio-Oil; D056804:Biofuels; D006838:Hydrocarbons; D010636:Phenols; D010938:Plant Oils; D059808:Polyphenols; D000536:Aluminum Hydroxide |
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