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Triage and monitoring of COVID-19 patients in intensive care using unsupervised machine learning. | BACKGROUND
We designed an algorithm to assess COVID-19 patients severity and dynamic intubation needs and predict their length of stay using the breathing frequency (BF) and oxygen saturation (SpO2) signals.
METHODS
We recorded the BF and SpO2 signals for confirmed COVID-19 patients admitted to the ICU of a teaching ... | 10.1016/j.compbiomed.2021.105192 | 34,998,220 | D000086382:COVID-19; D003422:Critical Care; D006801:Humans; D012189:Retrospective Studies; D000086402:SARS-CoV-2; D014218:Triage; D000069558:Unsupervised Machine Learning | Computers in biology and medicine | 2,022 | |
Anti-heart failure mechanism of saponin extract of black ginseng based on metabolomics. | OBJECTIVE
This study aimed to explore the mechanism of total saponin of black ginseng (TSBG) in treating heart failure (HF) in DOX-induced HF model rats.
METHODS
Rats with HF induced by the intraperitoneal injection of DOX were treated with TSBG (low dose, 30 mg/kg/day; medium dose, 60 mg/kg/day; high dose, 120 mg/kg... | 10.1016/j.jpba.2023.115738 | 37,742,504 | D051381:Rats; D000818:Animals; D017207:Rats, Sprague-Dawley; D051057:Proto-Oncogene Proteins c-akt; D012503:Saponins; D000071186:Beclin-1; D005894:Panax; D016718:Arachidonic Acid; D006333:Heart Failure; D058570:TOR Serine-Threonine Kinases; D055432:Metabolomics; D013654:Taurine; D013107:Sphingolipids | Journal of pharmaceutical and biomedical analysis | 2,023 | D051057:Proto-Oncogene Proteins c-akt; D012503:Saponins; D000071186:Beclin-1; D016718:Arachidonic Acid; C003949:hypotaurine; D058570:TOR Serine-Threonine Kinases; D013654:Taurine; D013107:Sphingolipids |
Genomic landscape of cutaneous T cell lymphoma. | Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and ap... | 10.1038/ng.3356 | 26,192,916 | D056915:DNA Copy Number Variations; D004252:DNA Mutational Analysis; D059472:Exome; D015870:Gene Expression; D005787:Gene Frequency; D056726:Genetic Association Studies; D023281:Genomics; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D012878:Sk... | Nature genetics | 2,015 | |
Application of electronic estrus detection technologies to reproductive management of cattle. | Artificial insemination and embryo transfer programs are dependent on efficient and accurate detection of estrus. Visual observation is accurate at detecting animals in estrus, but efficiency ranges from approximately 50 to 70%. Electronic technologies have been developed in attempts to improve estrus detection efficie... | 10.1016/s0093-691x(01)00663-x | 11,775,966 | D000818:Animals; D001947:Breeding; D002417:Cattle; D017097:Electric Impedance; D004624:Embryo Transfer; D004972:Estrus Detection; D005260:Female; D007315:Insemination, Artificial; D008297:Male; D009043:Motor Activity; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity | Theriogenology | 2,002 | |
Reduced visual acuity is mirrored in low vision imagery. | Research has examined the nature of visual imagery in normally sighted and blind subjects, but not in those with low vision. Findings with normally sighted subjects suggest that imagery involves primary visual areas of the brain. Since the plasticity of visual cortex appears to be limited in adulthood, we might expect ... | 10.1111/bjop.12493 | 33,543,491 | D000328:Adult; D001921:Brain; D006801:Humans; D015354:Vision, Low; D014792:Visual Acuity | British journal of psychology (London, England : 1953) | 2,021 | |
The contribution of animals to human well-being: a veterinary family practice perspective. | There is considerable evidence that humans can benefit both physically and emotionally from a relationship with companion animals, a phenomenon known as the human-animal bond (HAB). This has not only increased the demand for veterinary services to meet the needs of these non-human family members and their owners, but i... | 10.3138/jvme.35.4.540 | 19,228,906 | D000818:Animals; D001522:Behavior, Animal; D003142:Communication; D001841:Human-Animal Bond; D006801:Humans; D007398:Interpersonal Relations; D018634:Veterinarians; D014730:Veterinary Medicine | Journal of veterinary medical education | 2,008 | |
Fetal head injury from intentional penetrating abdominal trauma in pregnancy. | A male fetus was extruded from the uterus following multiple lower abdominal stab wounds to the mother. He was brought to the emergency room at 8 hours of age. He had sustained a compound skull fracture with brain contusion. There was no neurological deficit. Debridement and primary wound closure were undertaken. His m... | 10.1179/146532810X12637745452194 | 20,196,938 | D000007:Abdominal Injuries; D001930:Brain Injuries; D006259:Craniocerebral Trauma; D003646:Debridement; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D012887:Skull Fractures; D014951:Wounds, Stab | Annals of tropical paediatrics | 2,010 | |
Role of the kurtosis statistic in evaluating complex noise exposures for the protection of hearing. | OBJECTIVE
To highlight a selection of data that illustrate the need for better descriptors of complex industrial noise environments for use in the protection of hearing.
DESIGN
The data were derived using a chinchilla model. All noise exposures had the same total energy and the same spectrum; that is, they were equal... | 10.1097/AUD.0b013e3181b527a8 | 19,657,275 | D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold; D001933:Brain Stem; D002682:Chinchilla; D004430:Ear Protective Devices; D005072:Evoked Potentials, Auditory; D006198:Hair Cells, Auditory; D006317:Hearing Loss, Noise-Induced; D007245:Inferior Colliculi; D009622:Noise; D016011:Normal Distributio... | Ear and hearing | 2,009 | |
Postoperative nutrition of neonates undergoing heart surgery. | OBJECTIVE
Postoperative nutrition of newborns undergoing heart surgery (HS) is ill-defined. We compared the postoperative growth rates (grams/day) of neonates with congenital heart defects (CHDs) fed with their own mothers' milk (HU), a starting formula (SF; 67 kcal/100 mL), or a "preterm formula" (PF; 80 kcal/100 mL).... | 22,428,432 | D001942:Breast Feeding; D006348:Cardiac Surgical Procedures; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D011182:Postoperative Care | La Pediatria medica e chirurgica : Medical and surgical pediatrics | 2,011 | ||
Ultrasonographic Evaluation of Anterolateral Ligament Injuries: Correlation With Magnetic Resonance Imaging and Pivot-Shift Testing. | PURPOSE
(1) To compare the diagnostic ability of ultrasonography (US) and magnetic resonance imaging (MRI) to detect anterolateral ligament (ALL) injuries in anterior cruciate ligament (ACL)-deficient patients, and (2) to evaluate the correlation between ALL injury status (as determined by US and MRI) and the knee's ro... | 10.1016/j.arthro.2017.01.040 | 28,343,806 | D000328:Adult; D000070598:Anterior Cruciate Ligament Injuries; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010808:Physical Examination; D011446:Prospective Studies; D014463:Ultrasonography | Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2,017 | |
Percutaneous balloon compression for trigeminal neuralgias and autonomic cephalalgia. | OBJECTIVE
This prospective study aimed to evaluate the results of percutaneous trigeminal ganglion balloon compression (BC) in patients with various types of trigeminal neuralgia (TN) and autonomic cephalalgia.
METHODS
Twenty-five consecutive patients underwent BC and were followed up for 27-60 months. They were divi... | 10.1111/j.1526-4610.2007.00961.x | 18,005,140 | D000328:Adult; D000368:Aged; D002404:Catheterization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D016896:Treatment Outcome; D051303:Trigeminal Autonomic Cephalalgias; D014277:Trigeminal Neuralgia | Headache | 2,008 | |
Effect of ATG-F on B-cell reconstitution after hematopoietic stem cell transplantation. | Antithymocyte globulin Fresenius (ATG-F) is used before hematopoietic stem cell transplantation to prevent graft rejection and graft-versus-host disease in patients with HLA-matched unrelated donors or mismatched volunteers. However, little is known about the effect of ATG-F on the reconstitution of B-cell subsets. Six... | 10.1111/ejh.12524 | 25,677,646 | D000328:Adult; D000368:Aged; D000954:Antigens, Surface; D000961:Antilymphocyte Serum; D016175:B-Lymphocyte Subsets; D001402:B-Lymphocytes; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017578:Immunoglobulin Class Switching; D007156:Imm... | European journal of haematology | 2,015 | D000954:Antigens, Surface; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents |
Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells. | The influenza virus envelope glycoproteins hemagglutinin and neuraminidase were administered to the apical or basolateral sides of Caco-2 monolayers either as native protein micelles (mic-ag) or after incorporation into the orally active adjuvant formulation, immune stimulating complexes (iscoms) (isc-ag). Biotin-conju... | 10.1152/ajpgi.1996.270.4.G554 | 8,928,784 | D000276:Adjuvants, Immunologic; D000818:Animals; D000956:Antigens, Viral; D001692:Biological Transport; D018938:Caco-2 Cells; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008823:Micelles; D009975:Orthomyxoviridae; D014765:Viral Vaccines | The American journal of physiology | 1,996 | D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D008823:Micelles; D014765:Viral Vaccines |
Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite. | Structure-based virtual screening of NCI Diversity set II compounds was performed to indentify novel inhibitor scaffolds of trypanothione reductase (TR) from Leishmania infantum. The top 50 ranked hits were clustered using the AuPoSOM tool. Majority of the top-ranked compounds were Tricyclic. Clustering of hits yielded... | 10.1100/2012/963658 | 22,550,471 | D000818:Animals; D004791:Enzyme Inhibitors; D007700:Kinetics; D007891:Leishmania; D008958:Models, Molecular; D009247:NADH, NADPH Oxidoreductases | TheScientificWorldJournal | 2,012 | D004791:Enzyme Inhibitors; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase |
In vitro evaluation of ScopeSafe fibers and the scope guardian sheath in prevention of ureteroscope endolumenal working damage. | BACKGROUND AND PURPOSE
Ureteroscope breakage is commonly related to laser fiber damage. Often, the damage is mechanical and not energy related. As such, we evaluated a novel laser fiber and sheath system in preventing mechanical ureteroscope damage during fiber insertion.
MATERIALS AND METHODS
We assessed 200-μm/272/... | 10.1089/end.2012.0487 | 23,282,029 | D004867:Equipment Design; D004868:Equipment Failure; D020709:Ureteroscopes | Journal of endourology | 2,013 | |
Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system. | Opioid receptor subtypes may have site-specific effects and play different roles in modulating serotonergic neurotransmission in the mammalian central nervous system. To test this hypothesis, we used in vivo microdialysis to measure changes in extracellular serotonin (5-hydroxytryptamine; 5-HT) in response to local inf... | 10.1124/jpet.102.037861 | 12,388,635 | D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000701:Analgesics, Opioid; D000818:Animals; D002490:Central Nervous System; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D020881:Enkephalin, D-Penicillamine (2,5)-; D016308:Enkephalin, Leucine-2-Alanine; D008297:Male; D01... | The Journal of pharmacology and experimental therapeutics | 2,002 | D000701:Analgesics, Opioid; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D012701:Serotonin; D009271:Naltrexone; D016308:Enkephalin, Leucine-2-Alanine; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrro... |
A Comparison of the Performance of Myocardial Videodensitometry, Tissue Velocity Imaging and Tissue Tracking in Discrimination Between ST-Segment Elevation Ischemic Reperfusion Injury and Normal Reperfusion State After Non-Beating Cardiac Operation. | BACKGROUND
The timely diagnosis of presence or absence of reperfusion injury after cardiac operation is critical for the patient's outcome. Whether transesophageal echocardiography (TEE) acquisition of regional grayscale intensity (TI), velocity, and displacement (D) after cardiac operation can discriminate between pat... | 10.5812/iranjradiol.11393 | 25,780,544 | Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society | 2,014 | ||
Videogames and Health Improvement: A Literature Review of Randomized Controlled Trials. | OBJECTIVE
There are potential benefits of playing videogames for health improvement such as increasing knowledge about health-related issues by playing educational games and fighting a sedentary lifestyle by playing exergames. The number of systematic review articles about "videogames" and "health improvement" is limit... | 10.1089/g4h.2012.0031 | 26,191,999 | Games for health journal | 2,012 | ||
Lyotropic Cubic Phases for Drug Delivery: Diffusion and Sustained Release from the Mesophase Evaluated by Electrochemical Methods. | Lyotropic liquid crystalline systems are excellent carriers for drugs due to their biocompatibility, stability in aqueous environment, and well-defined structure that allow them to host significantly larger amounts of drugs than carriers such as liposomes or gold nanoparticles. Incorporating the drug within the mesopha... | 10.1021/acs.langmuir.5b03247 | 26,513,537 | D003692:Delayed-Action Preparations; D004058:Diffusion; D004317:Doxorubicin; D004337:Drug Carriers; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D050866:Liquid Crystals; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D014867:Water | Langmuir : the ACS journal of surfaces and colloids | 2,015 | D003692:Delayed-Action Preparations; D004337:Drug Carriers; D014867:Water; D004317:Doxorubicin |
Occupational exposure to asbestos and urinary bladder cancer. | By the use of transmission electron microscopy (TEM) and energy dispersion spectrometry the amount (mean value mean = 191 +/- 94 fibers/mg of tissue) and the type (chrysotile and tremolite) of asbestos fibers have been determined in tissue samples of four bladder cancer patients affected by pulmonary asbestosis, workin... | 10.1016/s0013-9351(05)80213-0 | 1,324,833 | D000368:Aged; D001194:Asbestos; D017632:Asbestos, Serpentine; D001195:Asbestosis; D002291:Carcinoma, Papillary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009784:Occupational Diseases; D012907:Smoking; D001749:Urinary Bladder Neoplasms | Environmental research | 1,992 | D017632:Asbestos, Serpentine; D001194:Asbestos |
Injuries sustained in National Collegiate Athletic Association men's and women's basketball, 2009/2010-2014/2015. | BACKGROUND/AIM
Recent rule changes regarding the safety of basketball athletes necessitate up-to-date reports of injury incidence. This study describes the epidemiology of injuries in men's and women's National Collegiate Athletic Association (NCAA) basketball during the 2009/2010-2014/2015 seasons.
METHODS
Basketbal... | 10.1136/bjsports-2016-096005 | 27,364,907 | D016512:Ankle Injuries; D056352:Athletes; D001265:Athletic Injuries; D001490:Basketball; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D013334:Students; D014495:Universities | British journal of sports medicine | 2,018 | |
Pure FSH induces ovulation in polycystic ovary syndrome despite rising androgen levels. | Five patients with carefully defined polycystic ovarian disease (PCOS) were treated with pure follicle stimulating hormone (FSH) to induce ovulation. Serum levels of androstenedione and testosterone were measured daily and noted to rise dramatically, reaching a maximum at the time of ovulation. However, despite the ris... | 3,130,977 | D000728:Androgens; D006063:Chorionic Gonadotropin; D005260:Female; D005640:Follicle Stimulating Hormone; D006801:Humans; D007247:Infertility, Female; D007273:Injections, Intramuscular; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome | Clinical reproduction and fertility | 1,987 | D000728:Androgens; D006063:Chorionic Gonadotropin; D005640:Follicle Stimulating Hormone | |
Highly selective 1,4- and 1,6-addition of P(O)-H compounds to p-quinones: a divergent method for the synthesis of C- and O-phosphoryl hydroquinone derivatives. | The reaction of P(O)-H compounds with p-quinones could proceed through either 1,4- or 1,6-addition pathways by employing different additives to selectively give the corresponding C- and O-phosphoryl hydroquinone derivatives in good yields. Oxidative double 1,4-addition of P(O)-H compounds to p-quinones was also achieve... | 10.1002/chem.201202074 | 23,143,865 | D006859:Hydrogen; D006873:Hydroquinones; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010084:Oxidation-Reduction; D010721:Phosphinic Acids; D011809:Quinones; D013237:Stereoisomerism | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,012 | D006873:Hydroquinones; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010721:Phosphinic Acids; D011809:Quinones; D006859:Hydrogen |
Safety of Laparoscopic Surgery for Colorectal Cancer in Patients with Severe Comorbidities. | BACKGROUND/AIM
Previous studies have shown that laparoscopic colorectal cancer surgery is highly safe and effective compared to laparotomy. However, whether laparoscopic colorectal cancer surgery can be safely performed in patients with severe comorbidities remains unclear. The aim of this study was to evaluate the saf... | 10.21873/anticanres.12659 | 29,848,741 | D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases; D015179:Colorectal Neoplasms; D015897:Comorbidity; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D010535:Laparoscopy; D008107:Liver Diseases; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies... | Anticancer research | 2,018 | |
Cervical Artery Dissections and Ischemic Strokes Associated with Vascular Neck Compression Techniques (Sportive Chokes). | BACKGROUND
Strangulation as a fight-finishing maneuver in combat sports, termed "choking" in that context, occurs worldwide millions of times yearly. This activity can be trained safely, but devastating injuries can occur.
OBJECTIVE
Our aim was to present a case series of cervical artery dissections and ischemic stro... | 10.1016/j.jemermed.2022.04.015 | 35,934,648 | D001158:Arteries; D020215:Carotid Artery, Internal, Dissection; D002637:Chest Pain; D006801:Humans; D000083242:Ischemic Stroke; D020521:Stroke; D020217:Vertebral Artery Dissection | The Journal of emergency medicine | 2,022 | |
Receptor clustering and transmembrane signaling in T cells. | T cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell surface. This process, which is a key step in the recognition of foreign antigens by the immune system, involves oligomerization of receptor components. Recent char... | 10.1016/s0968-0004(01)01815-1 | 11,343,923 | D000818:Animals; D000938:Antigen-Presenting Cells; D002462:Cell Membrane; D004789:Enzyme Activation; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D008954:Models, Biological; D011485:Protein Binding; D015398:Signal Transduction; D013601:T-Lymphocytes | Trends in biochemical sciences | 2,001 | D008024:Ligands |
UK Dental Medicines Advisory Service: questions asked by dentists - part 1: prescribing regulations and medicines use. | The UK Dental Medicines Advisory Service (UKDMAS) provides advice to dentists and other dental healthcare professionals concerning the use of medicines and medical devices in dentistry. The commonly asked questions posed to the UKDMAS concerning the prescribing, administering or dispensing of medicines in dental practi... | 10.1038/s41415-021-3470-5 | 34,625,687 | D003253:Consultants; D003815:Dentists; D006801:Humans; D006113:United Kingdom | British dental journal | 2,021 | |
Supplemental microbial phytase improves zinc utilization in broilers. | Day-old male broilers (n = 384) were used in a 21-d trial to investigate the effect of microbial phytase on the retention and utilization of Zn. A corn-soybean isolate basal diet containing 20 ppm Zn was fed alone and supplemented with 5, 10, or 20 ppm Zn as ZnSO4.7H2O or with 150, 300, 450, or 600 U of phytase/kg of d... | 10.3382/ps.0750540 | 8,786,946 | D010832:6-Phytase; D000821:Animal Feed; D000818:Animals; D002645:Chickens; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005527:Food, Fortified; D016014:Linear Models; D008099:Liver; D008297:Male; D011897:Random Allocation; D013025:Glycine max; D013977:Tibia; D014033:Toe Joint; D003313:Zea mays; D015032:Zinc | Poultry science | 1,996 | D010832:6-Phytase; D015032:Zinc |
Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism. | Acute pulmonary thromboembolism (PTE) refers to the obstruction of thrombus in pulmonary artery or its branches. Recent studies have suggested that PTE-induced endothelium injury is the major physiological consequence of PTE. And it is reasonal to use PTE-induced endothelium injury to stratify disease severity. Accordi... | 10.1371/journal.pone.0164530 | 27,798,647 | D000818:Animals; D015415:Biomarkers; D019295:Computational Biology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D011651:Pulmonary Artery; D011655:Pulmonary Embolism; D011817:Rabbits; D015203:Reproducibility of Results; D015398:... | PloS one | 2,016 | D015415:Biomarkers |
Reductive desorption of thiolate from monolayer protected gold clusters. | The "electrochemical potential window" of monolayer-protected gold cluster (MPC) nanoelectrodes is probed where the electrified liquid-liquid interface is used as the detector. The first observation of the reductive desorption of thiolate at negative MPC core charge is reported. | 10.1021/ja048431v | 15,186,141 | Journal of the American Chemical Society | 2,004 | ||
Sensitive electrochemical detection of nitric oxide based on AuPt and reduced graphene oxide nanocomposites. | Since nitric oxide (NO) plays a critical role in many biological processes, its precise detection is essential toward an understanding of its specific functions. Here we report on a facile and environmentally compatible strategy for the construction of an electrochemical sensor based on reduced graphene oxide (rGO) and... | 10.1039/c6an00429f | 27,143,513 | The Analyst | 2,016 | ||
Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. | Irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin; CPT-11) is a widely used potent antitumor drug that inhibits mammalian DNA topoisomerase I (Topo I); however, overexpression of ABCG2 (BCRP/MXR/ABCP) can confer cancer cell resistance to SN-38, the active form of CPT-11. We have recently de... | 10.1002/ijc.20216 | 15,170,677 | D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000255:Adenosine Triphosphate; D000970:Antineoplastic Agents; D001692:Biological Transport; D002166:Camptothecin; D018288:Carcinoma, Small Cell; D045744:Cell Line, Tumor; D002462:Cell Membrane; D003001:Clonin... | International journal of cancer | 2,004 | C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D011994:Recombinant Proteins; D000255:Adenosine Triphosphate; D002166:Camptothecin |
Anaesthesiological experiences with whole body hyperthermia. | OBJECTIVE
In order to investigate the safety of whole body hyperthermia (WBH) within the context of systemic Cancer Multistep Therapy (sCMT) in patients with disseminated malignancies, cardiopulmonary changes and various organ functions were examined.
METHODS AND PROCEDURES
Fifty-seven sCMT treatments were performed ... | 10.1080/02656730210143596 | 12,519,707 | D000328:Adult; D000776:Anesthesiology; D015179:Colorectal Neoplasms; D005260:Female; D005263:Femoral Artery; D018237:Germinoma; D006439:Hemodynamics; D006801:Humans; D006979:Hyperthermia, Induced; D007668:Kidney; D008168:Lung; D008223:Lymphoma; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D010051:Ovarian Neopl... | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 2,003 | |
[New sources of occupational exposure in modified or new technological processes]. | Mixtures of organic solvents with frequently changing composition are employed in many industries. It is true that dangerous solvents are eliminated from the work environment, but simultaneously new manufacturing techniques are implemented. Glues, varnishes and stains, containing chemicals of unknown toxicity and non-r... | 11,928,674 | D000269:Adhesives; D002849:Chromatography, Gas; D004396:Coloring Agents; D006801:Humans; D013058:Mass Spectrometry; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure; D010150:Paint; D011044:Poland; D012997:Solvents | Medycyna pracy | 2,001 | D000269:Adhesives; D004396:Coloring Agents; D012997:Solvents | |
Dynamics of binary mixtures of an ionic liquid and ethanol by NMR. | A study of molecular dynamics of the ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoro-methylsulphonyl)imide ([Emim][Tf2N]) in solution with deuterated ethanol at different molar concentration and temperatures is presented. The study was performed using 1 H and 2 H nuclear magnetic relaxation and 2 H 1D spectrosco... | 10.1002/mrc.4620 | 28,568,740 | Magnetic resonance in chemistry : MRC | 2,018 | ||
The art of clinical management in pharmacologic trials with depressed elderly patients: lessons from the Pittsburgh Study of Maintenance Therapies in Late-Life Depression. | The authors outline the clinical management methods used in a long-term study of depressed elderly patients and comment on the positive aspects of such interventions on the successful recruitment and retention of subjects. Psychosocial or clinical management (CM) is the "glue" that holds a successful drug trial togethe... | 10.1097/00019442-199908000-00007 | 10,438,694 | D000368:Aged; D000929:Antidepressive Agents, Tricyclic; D002986:Clinical Trials as Topic; D003865:Depressive Disorder, Major; D004311:Double-Blind Method; D006801:Humans; D009661:Nortriptyline; D010348:Patient Care Team; D010349:Patient Compliance; D010353:Patient Education as Topic; D010554:Personality Disorders; D011... | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 1,999 | D000929:Antidepressive Agents, Tricyclic; D009661:Nortriptyline |
STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. | The coactivator TIF2 was predicted to interact with an unknown factor to modify both the relative inhibition in glucocorticoid receptor (GR)-mediated gene repression and several parameters of agonists and antisteroids in GR-regulated induction. Here, we describe the isolation and characterization of the predicted facto... | 10.1128/MCB.01360-06 | 17,116,691 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002352:Carrier Proteins; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015536:Down-Regulation; D006801:Humans; D008969:Molecular Sequence Data; D051958:Nuclear Receptor Coactivator 2; D01148... | Molecular and cellular biology | 2,007 | D002352:Carrier Proteins; D018076:DNA, Complementary; D051958:Nuclear Receptor Coactivator 2; D034741:RNA, Small Interfering; D011965:Receptors, Glucocorticoid; C517816:TTLL5 protein, human |
Cerebrospinal fluid vasopressin as a marker of central nervous system metastases from small-cell bronchogenic carcinoma. | Vasopressin (ADH) was measured in CSF and plasma in 75 evaluable patients with known or suspected CNS metastases from small-cell bronchogenic carcinoma (SCBC), and in 66 control patients having neither malignant disease nor organic CNS disease. The presence of CNS metastases was confirmed or excluded on the basis of co... | 10.1200/JCO.1985.3.1.48 | 2,981,291 | D002283:Carcinoma, Bronchogenic; D018288:Carcinoma, Small Cell; D002493:Central Nervous System Diseases; D006801:Humans; D007177:Inappropriate ADH Syndrome; D007427:Intracranial Pressure; D008175:Lung Neoplasms; D008577:Meningeal Neoplasms; D009362:Neoplasm Metastasis; D014667:Vasopressins | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 1,985 | D014667:Vasopressins |
Entropy effects in the collective dynamic behavior of alkyl monolayers tethered to Si(111). | Dynamic properties of n-alkyl monolayers covalently bonded to Si(111) were studied by broadband admittance spectroscopy as a function of the temperature and the applied voltage using rectifying Hg/C12H25/n-type Si junctions. Partial substitution of methyl end groups by polar (carboxylic acid) moieties was used to enhan... | 10.3762/bjnano.6.60 | 25,821,699 | Beilstein journal of nanotechnology | 2,015 | ||
The Effect of Femoral Fixation on Revision and Mortality Following Elective Total Hip Arthroplasty in Patients Over the Age of 65 years. An Analysis of the American Joint Replacement Registry. | BACKGROUND
With the overwhelming use of cementless femoral fixation for primary total hip arthroplasty in the United States, the associations of stem fixation on the risk of revision and mortality are poorly understood. We evaluated the relationship between femoral fixation and risk of revision and mortality in patient... | 10.1016/j.arth.2022.01.088 | 35,131,391 | D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D001843:Bone Cements; D006622:Hip Prosthesis; D006801:Humans; D057068:Periprosthetic Fractures; D011474:Prosthesis Design; D012042:Registries; D012086:Reoperation; D012307:Risk Factors; D014481:United States | The Journal of arthroplasty | 2,022 | D001843:Bone Cements |
Multidisciplinary treatment of colorectal cancer in New Zealand: survival rates from 1997-2002. | INTRODUCTION
The surgical and oncological treatment of colorectal cancer has undergone steady evolution over the last 20 years, however nationally derived survival figures have been disappointingly slow to improve. This study is an analysis of prospectively collected data (taken over a 6-year period) on the outcome of ... | 16,998,579 | D000368:Aged; D015179:Colorectal Neoplasms; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009367:Neoplasm Staging; D009520:New Zealand; D010043:Outcome and Process Assessment, Health Care; D010348:Patient Care Team; D011379:Prognosis; D... | The New Zealand medical journal | 2,006 | ||
New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. | Despite significant reduction of cardiovascular events by statin treatment, substantial residual risk persists, driving emerging needs for the development of new therapies. We identified a novel cholesteryl ester transfer protein (CETP) inhibitor, K-312, that raises HDL and lowers LDL cholesterol levels in animals. K-3... | 10.1152/ajpendo.00528.2014 | 26,015,437 | D000818:Animals; D000924:Anticholesteremic Agents; D002478:Cells, Cultured; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; D015971:Gene Expression Regulation, Enzymologic; D056945:Hep G2 Cells; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D000071449:Proprotein Convertase... | American journal of physiology. Endocrinology and metabolism | 2,015 | D000924:Anticholesteremic Agents; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases |
STL-decomposition ensemble deep learning models for daily reservoir inflow forecast for hydroelectricity production. | Accurate reservoir inflow forecasting is crucial for efficient water management. In this study, different deep learning models, including Dense, Long short-term memory (LSTM), and one-dimensional convolutional neural networks (Conv1D), were used to build ensembles. Seasonal-trend decomposition using loess (STL) was app... | 10.1016/j.heliyon.2023.e16456 | 37,303,512 | Heliyon | 2,023 | ||
Investigation of genetic diversity and polyandry of Leptinotarsa decemlineata using X-linked microsatellite markers. | A panel of X-linked microsatellite markers was newly designed using the data from a previous sequencing project available in NCBI and used for a study of the Colorado potato beetle (CPB, Leptinotarsa decemlineata) X-haplotype variability. The analysis of scaffolds 49 and 61 (newly identified as fragments of CPB chromos... | 10.1038/s41598-023-49002-7 | 38,081,876 | Scientific reports | 2,023 | ||
The statistical evaluation of a three-period two-treatment crossover pharmacokinetic drug interaction study. | In a pharmacokinetic drug interaction study, the purpose is to determine whether the coadministration of a drug A with a second drug B alters the absorption/distribution/metabolism/elimination profile of either drug. While the usual design for such studies is a three-period crossover, it cannot be analyzed as such, bec... | 2,822,158 | D000806:Angiotensin-Converting Enzyme Inhibitors; D004077:Digoxin; D004347:Drug Interactions; D004656:Enalapril; D006801:Humans; D017706:Lisinopril; D008433:Mathematics | Biometrics | 1,987 | D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D004077:Digoxin; D017706:Lisinopril | |
Relationship between gamma-glutamyl transpeptidase activity and garlic greening, as controlled by temperature. | It was established that storage at low temperature (less than 10 degrees C) was required for garlic greening occurring either during processing or in the course of "Laba" garlic preparation while storage at high temperature (higher than 20 degrees C) inhibited its occurrence. However, the reason for this observation is... | 10.1021/jf072470j | 18,205,306 | D005519:Food Preservation; D005737:Garlic; D010860:Pigments, Biological; D018517:Plant Roots; D013696:Temperature; D013997:Time Factors; D005723:gamma-Glutamyltransferase | Journal of agricultural and food chemistry | 2,008 | D010860:Pigments, Biological; D005723:gamma-Glutamyltransferase |
A Metabolic Switch for Th17 Pathogenicity. | T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-... | 26,638,065 | D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental; D006801:Humans; D017423:Sequence Analysis, RNA; D059010:Single-Cell Analysis; D058504:Th17 Cells | Cell | 2,015 | ||
Complete transection of common bile duct due to blunt abdominal trauma: a case report and literature review. | A case of complete transection of the common bile duct due to abdominal blunt injury in a 49-year-old man is presented. The rarity of this injury and its initial presentation as a pancreatic pseudocyst warrant its description. This patient was diagnosed as having bile duct injury following ascites aspiration. Common bi... | 8,099,833 | D002758:Cholangiography; D002768:Choledochostomy; D003135:Common Bile Duct; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010192:Pancreatic Pseudocyst; D012187:Retroperitoneal Space; D014057:Tomography, X-Ray Computed; D014949:Wounds, Nonpenetrating | Journal of the Formosan Medical Association = Taiwan yi zhi | 1,993 | ||
[Inhaltsstoffe aus Wurzelrinde und Stammholz von Afraegle paniculata]. | The isolation of the coumarins xanthyletin, imperatorin, (+)-heraclenin and xanthoxyletin from the rootbark of A. Paniculata (Schum. et Thonn.) Engl. is reported. From the heartwood of the same plant the coumarins scoparon, xanthotoxin, imperatorin, (+)-heraclenin, 6-hydroxy-7-methoxy-coumarin and marmesin as well as t... | 10.1055/s-2007-971510 | 17,402,046 | Planta medica | 1,981 | ||
Assembly of export-competent mRNP: it's all about being connected. | In this issue of Molecular Cell, Johnson et al. (2009) reveal a physical link between the yeast Pcf11p and Yra1p proteins, providing insights into the coupling of mRNA 3' end formation and export. | 10.1016/j.molcel.2009.01.002 | 19,187,754 | D021581:Active Transport, Cell Nucleus; D005656:Fungal Proteins; D008954:Models, Biological; D012333:RNA, Messenger; D012261:Ribonucleoproteins | Molecular cell | 2,009 | D005656:Fungal Proteins; D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein |
[Does a preventive treatment of pregnancy toxemia exist: the role of aspirin]. | After studying the risk factors of eclamptic toxemia, the author describes the various methods of prevention proposed. A salt-free diet has no effect. Increased intake of zinc or magnesium has no impact. Calcium (600 to 2,000 mg/d) may reduce the incidence of toxemia among teenagers from 27.9% to 4%. Low dose aspirin a... | 8,469,865 | D001241:Aspirin; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D012307:Risk Factors | Revue francaise de gynecologie et d'obstetrique | 1,993 | D001241:Aspirin | |
Chromosomal Context Affects the Molecular Evolution of Sex-linked Genes and Their Autosomal Counterparts in Turtles and Other Vertebrates. | Sex chromosomes evolve differently from autosomes because natural selection acts distinctly on them given their reduced recombination and smaller population size. Various studies of sex-linked genes compared with different autosomal genes within species support these predictions. Here, we take a novel alternative appro... | 10.1093/jhered/esx082 | 29,036,698 | D000818:Animals; D019143:Evolution, Molecular; D008322:Mammals; D008957:Models, Genetic; D010802:Phylogeny; D012730:Sex Chromosomes; D014426:Turtles | The Journal of heredity | 2,017 | |
Design, synthesis and structure of novel G-2 melamine-based dendrimers incorporating 4-(n-octyloxy)aniline as a peripheral unit. | Background: 4-(n-Octyloxy)aniline is a known component in the elaboration of organic materials with mesogenic properties such as N-substituted Schiff bases, perylene bisimide assemblies with a number of 2-amino-4,6-bis[4-(n-octyloxy)phenylamino]-s-triazines, amphiphilic azobenzene-containing linear-dendritic block copo... | 10.3762/bjoc.14.145 | 30,112,076 | Beilstein journal of organic chemistry | 2,018 | ||
One round of SELEX for the generation of DNA aptamers directed against KLK6. | Kallikrein-related peptidase 6 (KLK6) is an active serine protease that has been implicated in common pathologies, including neurodegenerative disorders such as Parkinson and Alzheimer disease and certain types of cancer. Antibodies, either polyclonal or monoclonal, that exhibit specificity for distinct members of the ... | 22,505,517 | D000818:Animals; D052157:Aptamers, Nucleotide; D001483:Base Sequence; D015374:Biosensing Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007610:Kallikreins; D051379:Mice; D008958:Models, Molecular; D011487:Protein Conformation; D052156:SELEX Aptamer Technique; D012709:Serum Albumin | Biological chemistry | 2,012 | D052157:Aptamers, Nucleotide; D012709:Serum Albumin; C103551:KLK6 protein, human; D007610:Kallikreins | |
Diurnal changes in shoot water dynamics are synchronized with hypocotyl elongation in Arabidopsis thaliana. | We recently demonstrated the circadian clock modulated water dynamics in the roots of a small model plant, Arabidopsis thaliana, by the Nuclear Magnetic Resonance (NMR) microimaging technique. Our developed technique was able to visualize the water distribution that depended on differences in the (1)H signal among regi... | 23,299,330 | D017360:Arabidopsis; D057906:Circadian Clocks; D002940:Circadian Rhythm; D018546:Hypocotyl; D008027:Light; D017440:Photoperiod; D018517:Plant Roots; D018520:Plant Shoots; D014867:Water | Plant signaling & behavior | 2,013 | D014867:Water | |
Specific [3H]piflutixol binding to CHAPS-solubilised rat striatal preparations involves dopamine D-2 but not D-1 binding sites. | [3H]Piflutixol binding to rat striatal membrane preparations identifies both D-1 and D-2 sites. We used [3H]piflutixol to characterise those binding sites present in 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS)-solubilised rat striatal preparations. The specific binding of [3H]piflutixol, as define... | 10.1111/j.1471-4159.1986.tb12984.x | 3,941,314 | D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002793:Cholic Acids; D002850:Chromatography, Gel; D003342:Corpus Striatum; D005475:Flupenthixol; D007536:Isomerism; D007700:Kinetics; D051381:Rats; D011954:Receptors, Dopamine; D012995:Solubility; D013134:Spiperone; D013469:Sulpiride; D013892:Thioxa... | Journal of neurochemistry | 1,986 | D002793:Cholic Acids; D011954:Receptors, Dopamine; D013892:Thioxanthenes; D013134:Spiperone; D013469:Sulpiride; C015448:piflutixol; D005475:Flupenthixol; C028213:3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate |
Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. | We have previously identified osteoactivin (OA), encoded by Gpnmb, as an osteogenic factor that stimulates osteoblast differentiation in vitro. To elucidate the importance of OA in osteogenesis, we characterized the skeletal phenotype of a mouse model, DBA/2J (D2J) with a loss-of-function mutation in Gpnmb. Microtomogr... | 24,462,663 | D000469:Alkaline Phosphatase; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D001842:Bone and Bones; D002454:Cell Differentiation; D005136:Eye Proteins; D008297:Male; D008562:Membrane Glycoproteins; D051379:Mice; D008811:Mice, Inbred DBA; D009154:Mutation; D010006:Osteoblasts; D015675:Osteocalcin; D01001... | The American journal of pathology | 2,014 | D005136:Eye Proteins; C445671:Gpnmb protein, mouse; D008562:Membrane Glycoproteins; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D015675:Osteocalcin; D000469:Alkaline Phosphatase | |
CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells. | The Golgi assembly pattern varies among cell types. In fibroblast cells, the Golgi apparatus concentrates around the centrosome that radiates microtubules; whereas in epithelial cells, whose microtubules are mainly noncentrosomal, the Golgi apparatus accumulates around the nucleus independently of centrosome. Little is... | 10.1016/j.jgg.2016.11.005 | 28,089,391 | D004847:Epithelial Cells; D006056:Golgi Apparatus; D006801:Humans; D008869:Microtubule-Associated Proteins; D008870:Microtubules | Journal of genetics and genomics = Yi chuan xue bao | 2,017 | C000608274:Camsap3 protein, human; D008869:Microtubule-Associated Proteins |
Use of biogas solid residue from anaerobic digestion as an effective amendment to remediate Cr(VI)-contaminated soils. | Chromium (Cr) is one of the most common metal pollutants and has thus attracted considerable attention. In this study, we investigated the potential use of biogas solid residue (BSR) from anaerobic digestion as an effective amendment to decrease the bioavailability of Cr in Cr(VI)-polluted soil using pot experiments. C... | 10.1007/s11356-019-04786-y | 30,895,546 | D000693:Anaerobiosis; D056804:Biofuels; D001682:Biological Availability; D018533:Biomass; D002857:Chromium; D004787:Environmental Pollution; D018517:Plant Roots; D012987:Soil; D012989:Soil Pollutants | Environmental science and pollution research international | 2,019 | D056804:Biofuels; D012987:Soil; D012989:Soil Pollutants; D002857:Chromium; C074702:chromium hexavalent ion |
[Genetic subtyping of HIV-1 strains by heteroduplex mobility assay]. | DNA fragments of HIV-1 env gene were amplified by nested PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from 24 HIV-1 infected individuals. The PCR products were separated by melting and annealing with denatured PCR product prepared from reference plasimd of representative subtypes. Heteroduple... | 9,812,517 | D000163:Acquired Immunodeficiency Syndrome; D004279:DNA, Viral; D015752:Genes, env; D015497:HIV-1; D006801:Humans; D009692:Nucleic Acid Heteroduplexes; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | 1,997 | D004279:DNA, Viral; D009692:Nucleic Acid Heteroduplexes | |
Survey of Patient-Centered Coordination of Care for Diabetes with Cardiovascular and Mental Health Comorbidities in the Department of Veterans Affairs. | BACKGROUND
Multiple comorbidities thought to be associated with poor coordination due to the need for shared treatment plans and active involvement of patients, among other factors. Cardiovascular and mental health comorbidities present potential coordination challenges relative to diabetes.
OBJECTIVE
To determine ho... | 10.1007/s11606-019-04979-8 | 31,098,975 | D000368:Aged; D002318:Cardiovascular Diseases; D015897:Comorbidity; D003266:Continuity of Patient Care; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D017060:Patient Satisfaction; D018802:Patient-Centered Care; D057566:Self Report; D01448... | Journal of general internal medicine | 2,019 | |
Genomic characterization of phenotypic variants of beet curly top virus. | Full-length infectious DNA clones were constructed for four distinct phenotypic variants of beet curly top virus (BCTV). Southern hybridization assays indicated that each cloned BCTV genome shared sequence homology with pBCT-028, a full-length infectious DNA clone of a California isolate of BCTV previously characterize... | 10.1099/0022-1317-71-10-2211 | 2,230,726 | D015139:Blotting, Southern; D003001:Cloning, Molecular; D004279:DNA, Viral; D010641:Phenotype; D010942:Plant Viruses; D010944:Plants; D015183:Restriction Mapping; D014779:Virus Replication | The Journal of general virology | 1,990 | D004279:DNA, Viral |
The suppressive effects of miR-508-5p on the odontogenic differentiation of human dental pulp stem cells by targeting glycoprotein non-metastatic melanomal protein B. | BACKGROUND
Although the involvement of glycoprotein non-metastatic melanomal protein B (GPNMB) in regulating the odontogenic differentiation of human dental pulp stem cells (hDPCs) has been identified, the underlying mechanisms are largely unknown. The purpose of this study is to investigate the effects of miR-508-5p o... | 10.1186/s13287-019-1146-8 | 30,670,091 | D002454:Cell Differentiation; D003782:Dental Pulp; D015536:Down-Regulation; D006801:Humans; D008562:Membrane Glycoproteins; D035683:MicroRNAs; D009805:Odontogenesis; D013234:Stem Cells | Stem cell research & therapy | 2,019 | C503042:GPNMB protein, human; C571981:MIRN508 microRNA, human; D008562:Membrane Glycoproteins; D035683:MicroRNAs |
Enzymatic production of sugar from fungi and fungi-infected lignocellulosic biomass by a new cellulosomal enzyme harboring N-acetyl-β-d-glucosaminidase activity. | Cellulosomes are scaffold proteins displaying enzymes on the cell wall to efficiently obtain nutrient sources. CcGlcNAcase is a novel cellulosomal component. Based on sequence analysis, CcGlcNAcase was predicted to be a chitinolytic enzyme based on high homology with the discoidin domain-containing protein and chitobia... | 10.1016/j.biortech.2020.124242 | 33,254,465 | D000118:Acetylglucosaminidase; D018533:Biomass; D005658:Fungi; D008031:Lignin; D000073893:Sugars | Bioresource technology | 2,021 | D000073893:Sugars; C036909:lignocellulose; D008031:Lignin; D000118:Acetylglucosaminidase |
Genomic Signatures for Species-Specific Adaptation in Lake Victoria Cichlids Derived from Large-Scale Standing Genetic Variation. | The cichlids of Lake Victoria are a textbook example of adaptive radiation, as >500 endemic species arose in just 14,600 years. The degree of genetic differentiation among species is very low due to the short period of time after the radiation, which allows us to ascertain highly differentiated genes that are strong ca... | 10.1093/molbev/msab084 | 33,744,961 | D000220:Adaptation, Biological; D000483:Alleles; D000818:Animals; D023681:Cichlids; D049810:Genetic Speciation; D014644:Genetic Variation; D016678:Genome; D060106:Lakes; D011156:Population Density; D013045:Species Specificity; D013636:Tanzania | Molecular biology and evolution | 2,021 | |
Administration of melatonin protects against acetylsalicylic acid-induced impairment of male reproductive function in mice. | OBJECTIVES
Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA... | 10.22038/IJBMS.2017.23833.5989 | 29,456,808 | Iranian journal of basic medical sciences | 2,018 | ||
Serotonergic modulation of neurotransmission in the rat basolateral amygdala. | Whole cell patch-clamp recordings were obtained from projection neurons and interneurons of the rat basolateral amygdala (BLA) to understand local network interactions in morphologically identified neurons and their modulation by serotonin. Projection neurons and interneurons were characterized morphologically and elec... | 10.1152/jn.1999.82.1.69 | 10,400,936 | D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000679:Amygdala; D000818:Animals; D001640:Bicuculline; D005071:Evoked Potentials; D019706:Excitatory Postsynaptic Potentials; D058787:GABA-A Receptor Antagonists; D066298:In Vitro Techniques; D007395:Interneurons; D008297:Male; D009474:Neurons; D018408:Patch-Clamp Techni... | Journal of neurophysiology | 1,999 | D058787:GABA-A Receptor Antagonists; D011810:Quinoxalines; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; C052561:CGS 12066B; C042390:alpha-methylserotonin; D012701:Serotonin; C017069:bicuculline methiodide; D013779:Tetrodotox... |
Diagnosis and management of Waldenström macroglobulinemia: Mayo stratification of macroglobulinemia and risk-adapted therapy (mSMART) guidelines. | Waldenström macroglobulinemia is a B-cell malignancy with lymphoplasmacytic infiltration in the bone marrow or lymphatic tissue and a monoclonal immunoglobulin M protein (IgM) in the serum. It is incurable with current therapy, and the decision to treat patients as well as the choice of treatment can be complex. Using ... | 10.4065/mcp.2010.0304 | 20,702,770 | D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D001809:Blood Viscosity; D004359:Drug Therapy, Combination; D006801:Humans; D007155:Immunologic Factors; D010956:Plasmapheresis; D011379:Prognosis; D012008:Recurrence; D012307:... | Mayo Clinic proceedings | 2,010 | D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D000069283:Rituximab |
A single-chain-variable-fragment fluorescence biosensor activates fluorogens from dissimilar chemical families. | Current advancements in biological protein discovery utilize bi-partite methods of fluorescence detection where chromophore and scaffold are uncoupled. One such technology, called fluorogen-activating proteins (FAPs), consists of single-chain-variable-fragments (scFvs) selected against small organic molecules (fluoroge... | 24,939,660 | D015374:Biosensing Techniques; D005456:Fluorescent Dyes; D057809:HEK293 Cells; D006801:Humans; D057127:Single-Chain Antibodies | Protein and peptide letters | 2,014 | D005456:Fluorescent Dyes; D057127:Single-Chain Antibodies | |
Does Family Cohesion Predict Children's Effort? The Mediating Roles of Sense of Coherence, Hope, and Loneliness. | The degree of cohesion and support within families has often been considered a predictor of students' effort-investment and success in school. The objectives of this study are to examine the roles of personal factors (i.e., sense of coherence and hopeful thinking) as well as interpersonal factors (i.e., loneliness) in ... | 10.1080/00223980.2018.1447434 | 29,652,639 | D000076363:Academic Success; D000223:Adaptation, Psychological; D002648:Child; D005195:Family Relations; D005260:Female; D065026:Hope; D006801:Humans; D007557:Israel; D008132:Loneliness; D008297:Male; D009042:Motivation; D012307:Risk Factors; D012574:Schools; D060685:Sense of Coherence; D013334:Students; D011795:Survey... | The Journal of psychology | 2,018 | |
SMAC exhibits anti-tumor effects in ECA109 cells by regulating expression of inhibitor of apoptosis protein family. | BACKGROUND
The poor prognosis and rising incidence of esophageal cancer highlight the need for improved therapeutics that are essential prior to treatment. LCL161 is an SMAC (second mitochondrial activator of caspases) mimic and inhibitor of apoptosis protein (IAP) antagonist which exhibits anti-tumor effects and impro... | 10.12998/wjcc.v9.i19.5019 | 34,307,552 | World journal of clinical cases | 2,021 | ||
Patient-reported Outcomes Measurement Information System (PROMIS) Scores for Children With Brachial Plexus Birth Injury. | BACKGROUND
Patient-reported Outcomes Measurement Information System (PROMIS) for pediatrics is a validated patient-reported or parent-proxy-reported outcomes assessment tool used to evaluate health-related quality of life in children and adolescents with chronic medical conditions. The health-related quality of life of... | 10.1097/BPO.0000000000001754 | 33,448,721 | D000293:Adolescent; D001720:Birth Injuries; D001917:Brachial Plexus; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of ... | Journal of pediatric orthopedics | 2,021 | |
The micro-determination of serum gamma-glutamyl transferase. | The method of serum gamma-glutamyl transferase colorimeter assay was modified by changing the wave length from 420 nm to 400 nm, the incubated temperature from 37 degrees C to 50 degrees C, the sample amount from 30 microliters to 6 microliters. The modified method was proved to be more sensitive, with CV of intra-grou... | 7,966,519 | D000328:Adult; D003124:Colorimetry; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012680:Sensitivity and Specificity; D005723:gamma-Glutamyltransferase | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao | 1,994 | D005723:gamma-Glutamyltransferase | |
Real-time ultrasound-guided stellate ganglion block for migraine: an observational study. | OBJECTIVE
To observe whether ultrasound-guided stellate ganglion block (SGB) can effectively relieve migraine pain and improve the quality of migraine patients' life.
METHODS
81 patients with migraines were enrolled in this study. The patients received SGB with 6 ml of 0.15% ropivacaine once every week for four times... | 10.1186/s12871-022-01622-8 | 35,331,152 | D001340:Autonomic Nerve Block; D006801:Humans; D008881:Migraine Disorders; D011788:Quality of Life; D013233:Stellate Ganglion; D018084:Ultrasonography, Interventional | BMC anesthesiology | 2,022 | |
Kratom exposures managed by the British Columbia poison centre, 2012-2019: a descriptive analysis. | BACKGROUND
Kratom, a plant indigenous to Southeast Asia, which has been used both recreationally and in the treatment of pain and opioid dependence, has received little scrutiny in the United States and almost none in Canada. We analyzed calls to the British Columbia poison centre to describe caller-declared exposures ... | 10.9778/cmajo.20210252 | 35,973,710 | D001955:British Columbia; D006801:Humans; D008297:Male; D032065:Mitragyna; D009293:Opioid-Related Disorders; D011042:Poisons; D013375:Substance Withdrawal Syndrome; D014481:United States; D055815:Young Adult | CMAJ open | 2,022 | D011042:Poisons |
Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats. | Growing evidence suggests that intake of flavonoid-containing foods may exert cardiovascular benefits in human subjects. We have investigated the effects of a 10-week blueberry (BB) supplementation on blood pressure (BP) and vascular reactivity in rats fed a high-fat/high-cholesterol diet, known to induce endothelial d... | 10.1017/S0007114512003911 | 23,046,999 | D000109:Acetylcholine; D000818:Animals; D001011:Aorta; D001794:Blood Pressure; D002791:Cholesterol, Dietary; D059305:Diet, High-Fat; D004041:Dietary Fats; D019587:Dietary Supplements; D004730:Endothelium, Vascular; D005419:Flavonoids; D005638:Fruit; D008297:Male; D009131:Muscle, Smooth, Vascular; D010656:Phenylephrine;... | The British journal of nutrition | 2,013 | D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005419:Flavonoids; D028321:Plant Preparations; D014665:Vasodilator Agents; D010656:Phenylephrine; D000109:Acetylcholine |
Prospective examination of psychological risk and maintenance factors for body image distress after mastectomy with immediate breast reconstruction. | Reconstructive breast surgery aims to improve body image following mastectomy, yet many women experience ongoing body image distress (BID). The relationship between the esthetic outcome of reconstructive surgery with BID has been underexplored in mastectomy. This study aimed to assess whether reconstruction outcome fol... | 10.1016/j.bodyim.2022.05.014 | 35,691,103 | D001828:Body Image; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008408:Mastectomy; D011446:Prospective Studies | Body image | 2,022 | |
[The TNM classification system in malignant conjunctival neoplasms]. | The authors submit a review of histological findings and classification according to the TNM-classification of conjunctival tumours in patients under dispensary care at the First Ophthalmological Clinic of the Faculty Hospital and Medical Clinic of the Comenius University in Bratislava during a 10-year period (1989-199... | 10,916,218 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D002648:Child; D002675:Child, Preschool; D003230:Conjunctival Neoplasms; D006801:Humans; D007223:Infant; D008545:Melanoma; D008875:Middle Aged | Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti | 2,000 | ||
Hantavirus pulmonary syndrome in Wisconsin. | In the spring of 1993 an outbreak of a new illness caused by a new pathogen was identified in the southwestern United States. This infection struck relatively young, healthy individuals, was characterized by fever, myalgias, respiratory failure, and a high mortality rate. This illness was caused by a new hantavirus and... | 9,046,232 | D000328:Adult; D000818:Animals; D004197:Disease Reservoirs; D018562:Disease Transmission, Infectious; D017809:Fatal Outcome; D006476:Orthohantavirus; D018778:Hantavirus Infections; D006801:Humans; D008297:Male; D011024:Pneumonia, Viral; D011859:Radiography; D012377:Rodentia; D013577:Syndrome | Wisconsin medical journal | 1,997 | ||
Reversible tyrosine phosphorylation/dephosphorylation of proline-directed protein kinase FA/glycogen synthase kinase-3alpha in A431 cells. | Modulation of protein kinase FA/glycogen synthase kinase-3alpha (kinase FA/GSK-3alpha) by reversible tyrosine phosphorylation/dephosphorylation was investigated. In addition to genistein, other protein tyrosine kinase (PTK) inhibitors, such as tyrphostin A47 and B42, also could induce tyrosine dephosphorylation and ina... | 10.1002/(SICI)1097-4652(199704)171:1<95::AID-JCP11>3.0.CO;2-N | 9,119,896 | D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002460:Cell Line; D038362:Glycogen Synthase Kinase 3; D010766:Phosphorylation; D015398:Signal Transduction; D014443:Tyrosine | Journal of cellular physiology | 1,997 | D014443:Tyrosine; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3 |
Impact of reactivity controlled compression ignition (RCCI) mode engine operation in diesel engine powered with B20 blend of waste cooking oil biodiesel. | The purpose of this study is to conduct an experimental assessment of the impact of RCCI (reactivity regulated compression ignition) on the performance, emissions, and combustion of a CRDI engine. A fuel mix (20% biodiesel, 80% diesel, and a NaOH catalyst) is generated. The produced combination is evaluated for attribu... | 10.1038/s41598-023-31044-6 | 36,959,305 | Scientific reports | 2,023 | ||
Adsorption of multiple NO molecules on Au10- and Au9Zn- planar clusters. A comparative DFT study. | The doping of atomic clusters with transition-metal atoms modifies to a lesser or greater extent the catalytic properties of the pure forms. Here we study by means of density functional theory (DFT) the adsorption of up to six NO molecules on Au10- and Au9Zn- clusters, both with well-tested D3h planar geometry, to lear... | 10.1039/d3cp01710a | 37,341,136 | Physical chemistry chemical physics : PCCP | 2,023 | ||
Molecular analysis and characterisation of the full-length flagellin C gene (flaC) from Campylobacter lari. | A degenerate polymerase chain reaction (PCR) primer pair (f-ClflaC/r-ClflaC) was constructed in silico to amplify flaC and its adjacent genetic loci from Campylobacter lari isolates. Approximately 1.45 kbp amplicons, including the sequences encoding the flaC structural gene of 750 bp, putative promoter, rho-independent... | 10.1080/09674845.2011.11732835 | 21,473,256 | D000595:Amino Acid Sequence; D001483:Base Sequence; D044863:Campylobacter lari; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D005408:Flagellin; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA | British journal of biomedical science | 2,011 | D004269:DNA, Bacterial; D005408:Flagellin |
Is Synaesthesia More Prevalent in Autism Spectrum Conditions? Only Where There Is Prodigious Talent. | Savant syndrome is a condition where prodigious talent co-occurs with developmental difficulties such as autism spectrum conditions (ASC). To better understand savant skills, we previously proposed a link with synaesthesia: that savant syndrome may arise in ASC individuals who also happen to have synaesthesia. A second... | 10.1163/22134808-00002558 | 31,287,074 | Multisensory research | 2,017 | ||
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. | The Murray Valley encephalitis virus (MVEV) and the West Nile virus (WNV) are mosquito-borne single-stranded RNA Flaviviruses responsible for many cases of viral encephalitis and deaths worldwide. The former is endemic in north Australia and Papua New Guinea while the latter has spread to different parts of the world a... | 24,333,681 | D000376:Agmatine; D004151:Dipeptides; D018068:Encephalitis Virus, Murray Valley; D020365:RNA Helicases; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; D014902:West Nile virus | Peptides | 2,014 | D004151:Dipeptides; C080102:NS2B protein, flavivirus; C060028:NS3 protein, flavivirus; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; D000376:Agmatine; D012697:Serine Endopeptidases; D020365:RNA Helicases | |
Differences in prolactin and LH responses to acute stress between peripuberal and adult male rats. | Pituitary-adrenal, pituitary-gonadal and prolactin responses to acute stress (restraint) were studied in peripuberal and adult male rats. The pituitary-adrenal response to restraint stress did not differ in peripuberal and adult rats. Prolactin increase during stress was less marked in peripuberal animals. While an inc... | 10.1677/joe.0.1120009 | 3,029,261 | D000208:Acute Disease; D000324:Adrenocorticotropic Hormone; D000375:Aging; D000818:Animals; D003345:Corticosterone; D007986:Luteinizing Hormone; D008297:Male; D011388:Prolactin; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological; D013739:Testosterone | The Journal of endocrinology | 1,987 | D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D003345:Corticosterone |
Single-cell technologies are revolutionizing the approach to rare cells. | In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. Th... | 10.1038/icb.2015.106 | 26,620,630 | D000818:Animals; D000938:Antigen-Presenting Cells; D023281:Genomics; D006412:Hematopoietic Stem Cells; D006801:Humans; D007107:Immune System; D059010:Single-Cell Analysis; D013950:Thymus Gland | Immunology and cell biology | 2,016 | |
Adaptation to Blue Light in Marine Synechococcus Requires MpeU, an Enzyme with Similarity to Phycoerythrobilin Lyase Isomerases. | Marine Synechococcus has successfully adapted to environments with different light colors, which likely contributes to this genus being the second most abundant group of microorganisms worldwide. Populations of Synechococcus that grow in deep, blue ocean waters contain large amounts of the blue-light absorbing chromoph... | 10.3389/fmicb.2017.00243 | 28,270,800 | Frontiers in microbiology | 2,017 | ||
Cochlear Implantation in Siblings With Refsum's Disease. | OBJECTIVES
Whether the origin of severe hearing loss in Refsum's syndrome is caused by cochlear impairment or retrocochlear degeneration remains unclear. This case report aims to investigate hearing performance before and after cochlear implantation to shed light on this question. Also, identification of new mutations ... | 10.1177/0003489417717269 | 28,681,609 | D001300:Audiometry, Evoked Response; D001301:Audiometry, Pure-Tone; D019929:Cochlear Implantation; D005260:Female; D006319:Hearing Loss, Sensorineural; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases; D017084:Otoacoustic Emissions, Spontaneous; D012035:Refsum Disease; D035781:Siblin... | The Annals of otology, rhinology, and laryngology | 2,017 | D006899:Mixed Function Oxygenases; C102623:PHYH protein, human |
Treating Women Who Are Pregnant and Parenting for Opioid Use Disorder and the Concurrent Care of Their Infants and Children: Literature Review to Support National Guidance. | OBJECTIVES
The prevalence of opioid use disorder (OUD) during pregnancy is increasing. Practical recommendations will help providers treat pregnant women with OUD and reduce potentially negative health consequences for mother, fetus, and child. This article summarizes the literature review conducted using the RAND/Univ... | 10.1097/ADM.0000000000000308 | 28,406,856 | D000701:Analgesics, Opioid; D001942:Breast Feeding; D002047:Buprenorphine; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008691:Methadone; D009357:Neonatal Abstinence Syndrome; D058850:Opiate Substitution Treatment; D009293:Opioid-Related Disorders; D016487:Parenting; D018... | Journal of addiction medicine | 2,017 | D000701:Analgesics, Opioid; D002047:Buprenorphine; D008691:Methadone |
Relationships between resting blood flow and the indices of muscle damage after eccentric contractions. | PURPOSE
The aim of the study is to examine the relationships between increments in resting blood flow and isometric maximal voluntary contraction (MVC) force reduction, muscle soreness, and swelling after eccentric contractions (ECs).
METHODS
Twenty-one young healthy men (age 20.8 ± 1.6 years; height 172.0 ± 5.3 cm; ... | 10.1007/s00421-020-04442-1 | 32,712,700 | D000293:Adolescent; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D018482:Muscle, Skeletal; D063806:Myalgia; D012039:Regional Blood Flow; D055815:Young Adult | European journal of applied physiology | 2,020 | |
Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways. | Calcitonin inhibits osteoclastic bone resorption and its action involves two separate acute effects on the osteoclast, both essential to the action of the hormone: abolition of cell motility (Q) and marked cellular retraction (R). The former was mimicked by dibutyryl cyclic AMP and cholera toxin and the latter by pertu... | 10.1677/joe.0.1260473 | 2,170,558 | D000535:Aluminum; D017607:Aluminum Compounds; D000818:Animals; D001862:Bone Resorption; D003994:Bucladesine; D002116:Calcitonin; D002118:Calcium; D002478:Cells, Cultured; D002772:Cholera Toxin; D005576:Colforsin; D003600:Cytosol; D005459:Fluorides; D019204:GTP-Binding Proteins; D015759:Ionomycin; D008094:Lithium; D0100... | The Journal of endocrinology | 1,990 | D017607:Aluminum Compounds; D010566:Virulence Factors, Bordetella; D005576:Colforsin; D015759:Ionomycin; D003994:Bucladesine; D002116:Calcitonin; D002772:Cholera Toxin; D008094:Lithium; D000535:Aluminum; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; D005459:Fluorides; D002118:Calcium; C032311:aluminum fluoride |
Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine manufactured with and without polysorbate 80 given to healthy infants at 2, 3, 4 and 12 months of age. | BACKGROUND
Polysorbate 80 (P80), a nonionic detergent used to solubilize proteins, is used in both oral and injectable medications including vaccines. Development studies with 13-valent pneumococcal conjugate vaccine (PCV13) showed that adding P80 resulted in a more robust manufacturing process. Before adding P80 to th... | 10.1097/INF.0000000000000511 | 25,126,854 | D000907:Antibodies, Bacterial; D004311:Double-Blind Method; D064420:Drug-Related Side Effects and Adverse Reactions; D005079:Excipients; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007074:Immunoglobulin G; D007223:Infant; D008297:Male; D009895:Opsonin Proteins; D010587:Phagocytosis; D022242:Pneumococca... | The Pediatric infectious disease journal | 2,015 | C538862:13-valent pneumococcal vaccine; D000907:Antibodies, Bacterial; D005079:Excipients; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; D011136:Polysorbates; D013501:Surface-Active Agents |
3-Amino-6-methoxy-9-(2-hydroxyethylamino) acridine: a new fluorescent dye to detect Mycoplasma contamination in cell cultures. | A new fluorescent acridine orange derivative, 3-amino-6-methoxy-9-(2-hydroxyethylamino) acridine (AMHA), has been applied to Hela cells in order to set up appropriate conditions for the detection of mycoplasma contaminations. Since AMHA staining reveals intensely fluorescent nuclei and slight fluorescent cytoplasm, we ... | 10.1007/BF00365100 | 1,367,045 | D000609:Aminoacridines; D002478:Cells, Cultured; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D009174:Mycoplasma | Cytotechnology | 1,990 | D000609:Aminoacridines; D005456:Fluorescent Dyes; C067451:3-amino-6-methoxy-9-(2-hydroxyethylamino)acridine |
Temperature and body weight affect fouling of pig pens. | Fouling of the solid lying area in pig housing is undesirable for reasons of animal welfare, animal health, environmental pollution, and labor costs. In this study the influence of temperature on the excreting and lying behavior of growing-finishing pigs of different BW (25, 45, 65, 85, or 105 kg) was studied. Ten grou... | 10.2527/jas.2005-521 | 16,864,884 | D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D006799:Housing, Animal; D006920:Hygiene; D013552:Swine; D013696:Temperature | Journal of animal science | 2,006 | |
Serotonin and norepinephrine uptake in discrete brain regions during the pregnant mare serum (PMS) induced estrous cycle in the rat. | The role of hypothalamic and limbic aminergic systems in neuroendocrine control in the rat has been investigated by measuring the temporal changes in serotonergic and noradrenergic neuronal uptake in a model of the estrous cycle. Using the pregnant mare serum (PMS) model of induced ovulation and an in vitro uptake syst... | 6,685,610 | D000818:Animals; D001921:Brain; D004971:Estrus; D005260:Female; D006064:Gonadotropins, Equine; D066298:In Vitro Techniques; D009638:Norepinephrine; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin; D013997:Time Factors; D014018:Tissue Distribution | Chronobiologia | 1,983 | D006064:Gonadotropins, Equine; D012701:Serotonin; D009638:Norepinephrine | |
Surface enhanced ellipsometric contrast (SEEC) basic theory and lambda/4 multilayered solutions. | The fundamentals of a new high contrast technique for optical microscopy, named "Surface Enhanced Ellipsometric Contrast" (SEEC), are presented. The technique is based on the association of enhancing contrast surfaces as sample stages and microscope observation between cross polarizers. The surfaces are designed to bec... | 10.1364/oe.15.008329 | 19,547,163 | Optics express | 2,007 | ||
The amount and activity of active matrix metalloproteinase 13 is suppressed by estradiol and progesterone in human pelvic floor fibroblasts. | As a key degrader of fibrillar collagens, matrix metalloproteinase 13 (MMP13), may contribute to the progression of pelvic organ prolapse. Here we aimed to define the regulation of MMP13 by estradiol and progesterone in the vaginal supportive tissues. Fibroblasts cultured from the arcus tendineous fasciae pelvis of thr... | 10.1095/biolreprod.108.072462 | 18,987,329 | D000290:Adnexa Uteri; D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D004789:Enzyme Activation; D004958:Estradiol; D005260:Female; D005347:Fibroblasts; D006801:Humans; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D008875:Middle Aged; D010052:Ovariectomy; D017773:Pelvic Flo... | Biology of reproduction | 2,009 | D061965:Matrix Metalloproteinase Inhibitors; D011374:Progesterone; D004958:Estradiol; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13 |
Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study. | OBJECTIVE
It is not established whether myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is associated with structural brain changes. The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS.
METHODS
High-resolution structural 3 T cerebral MRI scanni... | 10.1259/bjr/93889091 | 22,128,128 | D000328:Adult; D001921:Brain; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex; D015673:Fatigue Syndrome, Chronic; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Mi... | The British journal of radiology | 2,012 | |
[Association between glutamate receptor 2 polymorphisms and epilepsy in children]. | OBJECTIVE
To investigate the association between two single nucleotide polymorphisms (SNPs), rs9390754 and rs4840200, in the glutamate receptor 2 (GRIK2) gene and the genetic susceptibility to epilepsy (EP) in the Han population in Central China.
METHODS
A case-control study was performed in 284 EP children (includin... | 27,324,535 | D002648:Child; D002675:Child, Preschool; D004827:Epilepsy; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018092:Receptors, Kainic Acid; D012307:Risk Factors; D000097806:GluK2 Kainate Receptor | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics | 2,016 | D018092:Receptors, Kainic Acid |
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