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[Paranasal sinuses: postoperative imaging]. | Radiologic assessment after sinus surgery requires not only a good knowledge of the primary disease, but also a mandatory understanding of every surgical technique and approach. After having described these techniques, we will illustrate immediate, possible but rare, post-operative complications. The various pathologie... | 13,679,765 | D000230:Adenocarcinoma; D004724:Endoscopy; D005005:Ethmoid Sinus; D006801:Humans; D008279:Magnetic Resonance Imaging; D010255:Paranasal Sinus Neoplasms; D010256:Paranasal Sinuses; D011183:Postoperative Complications; D011184:Postoperative Period; D014057:Tomography, X-Ray Computed | Journal de radiologie | 2,003 | ||
Field visual perspective during autobiographical memory recall is less frequent among patients with schizophrenia. | There is growing interest in clinical research regarding the visual perspective adopted during memory retrieval, because it reflects individuals' self-attitude towards their memories of past personal events. Several autobiographical memory deficits, including low specificity of personal memories, have been identified i... | 23,932,447 | D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders; D061212:Memory, Episodic; D011939:Mental Recall; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia; D012565:Schizophrenic Psychology; D013223:Statistics as Topic; D0147... | Schizophrenia research | 2,013 | ||
Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity. | Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor cell-specific cytotoxicity. However, earlier studies with recombinant TRAIL revealed many shortcomings, includi... | 10.1038/cddis.2016.177 | 27,336,718 | D000256:Adenoviridae; D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D002470:Cell Survival; D005260:Female; D005818:Genetic Engineering; D006801:Humans; D008099:Liver; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D0... | Cell death & disease | 2,016 | D000970:Antineoplastic Agents; D011993:Recombinant Fusion Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand |
Extra-segmental reflexes derived from intercostal afferents: phrenic and laryngeal responses. | 1. Phrenic and recurrent laryngeal efferent responses were evoked by brief tetani or single shocks to the cut external intercostal nerves of anaesthetized cats. The reflexes derived from middle thoracic segments (T5 and 6) were compared with those emanating from caudal thoracic segments (T9 and 10).2. During inspiratio... | 10.1113/jphysiol.1973.sp010296 | 4,759,121 | D000200:Action Potentials; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004576:Electromyography; D007823:Laryngeal Nerves; D008465:Mechanoreceptors; D009046:Motor Neurons; D009132:Muscles; D009474:Neurons; D009475:Neurons, Afferent; D009476:Neurons, Efferent; D010791:Phrenic Nerve; D012018:Reflex; D012... | The Journal of physiology | 1,973 | |
[The effect of macromolecular adhesion factors isolated from the blood serum and liver of mammals on the intensity of protein synthesis and the ATP content in hepatocytes in vitro]. | The influence of the extra-low dozes of the macromolecular adhesive factors (MAF) on the protein synthesis and on the ATP contents in the rat hepatocytes on different models in vitro has been investigated. The protein synthesis intensity, the cell penetrability for labelled 3H-leucine and the intracell ATP contents in ... | 8,186,737 | D000255:Adenosine Triphosphate; D000818:Animals; D015815:Cell Adhesion Molecules; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D007930:Leucine; D008099:Liver; D046911:Macromolecular Substances; D014176:Protein Biosynthesis; D011506:Proteins; D051381:Rats; D017208:Rats, Wistar; D014316:Tritium | Izvestiia Akademii nauk. Seriia biologicheskaia | 1,994 | D015815:Cell Adhesion Molecules; D046911:Macromolecular Substances; D011506:Proteins; D014316:Tritium; D000255:Adenosine Triphosphate; D007930:Leucine | |
Learning a motor skill with spatial and temporal parameters. | The purpose of this study was to determine how individuals learned a motor skill having temporal and spatial parameters. For scores of 10 adult males one-way repeated-measures multivariate analysis indicated that subjects learned the skill but follow-up analysis showed acquisition occurred on accuracy only. Some proces... | 10.2466/pms.1982.55.1.211 | 7,133,906 | D000293:Adolescent; D000328:Adult; D001288:Attention; D006801:Humans; D007699:Kinesthesis; D008297:Male; D009048:Motor Skills; D009949:Orientation; D013028:Space Perception; D013998:Time Perception | Perceptual and motor skills | 1,982 | |
Substituting poly- and mono-unsaturated fat for dietary carbohydrate reduces hyperinsulinemia in women with polycystic ovary syndrome. | OBJECTIVE
Hyperinsulinemia is a prevalent feature of polycystic ovary syndrome (PCOS), contributing to metabolic and reproductive manifestations of the syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, thus preventing long-term benefits. In the absence of weight loss, replacement of dietary ... | 10.1080/09513590.2016.1259407 | 27,910,718 | D000328:Adult; D001786:Blood Glucose; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D005260:Female; D006801:Humans; D006946:Hyperinsulinism; D007328:Insulin; D007333:Insulin Resistance; D008055:Lipids; D009765:Obesity; D011085:Polycystic Ovary Syndrome; D016896:Treatment ... | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology | 2,017 | D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D007328:Insulin; D008055:Lipids |
Pancreatic PYY but not PPY expression is responsive to short-term nutritional state and the pancreas constitutes the major site of PYY mRNA expression in chickens. | PP-fold peptides such as peptide YY (PYY) and pancreatic polypeptide (PPY) are known to play key roles in vertebrate energy homeostasis. Until recently, no gene sequence was available for avian PYY and therefore a gap in knowledge of regulation of its expression exists in avian species. Here we further evidence the mRN... | 10.1016/j.ygcen.2017.07.002 | 28,694,054 | D000818:Animals; D001483:Base Sequence; D002645:Chickens; D018076:DNA, Complementary; D004386:Duodenum; D005247:Feeding Behavior; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007583:Jejunum; D009752:Nutritional Status; D010179:Pancreas; D010191:Pancreatic Polypeptide; D019894:Peptide YY; D011... | General and comparative endocrinology | 2,017 | D018076:DNA, Complementary; D012333:RNA, Messenger; D019894:Peptide YY; D010191:Pancreatic Polypeptide |
ACS NSQIP risk calculator reliability in head and neck oncology: The effect of prior chemoradiation on NSQIP risk estimates following laryngectomy. | PURPOSE
To determine whether inclusion of chemoradiation history increases estimated risk for complications following total laryngectomy using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Surgical Risk Calculator.
MATERIALS AND METHODS
A retrospective review of 96 patients wi... | 10.1016/j.amjoto.2017.11.005 | 29,174,070 | D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms; D007825:Laryngectomy; D008297:Male; D009367:Neoplasm Staging; D011183:Postoperative Complications; D058996:Quality Improvement; D012372:ROC Curve... | American journal of otolaryngology | 2,018 | |
Current Applications and Benefits of Polymeric Nanocarriers for the Management of Skin Disorders. | Preparations for topical application are highly important for therapeutic and cosmetic use since the skin has an extensive and accessible application area. Among the many advantages, this route avoids the systemic effects of the substances and, therefore, fewer adverse reactions are observed. However, the skin is an or... | 10.2174/0929867329666220525141021 | 35,619,267 | D000279:Administration, Cutaneous; D003358:Cosmetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D000080385:Nanogels; D053758:Nanoparticles; D004364:Pharmaceutical Preparations; D011108:Polymers; D012867:Skin; D012869:Skin Absorption; D012871:Skin Diseases | Current medicinal chemistry | 2,022 | D003358:Cosmetics; D004337:Drug Carriers; D000080385:Nanogels; D004364:Pharmaceutical Preparations; D011108:Polymers |
Significance of p53 immunostaining in mesothelial proliferations and correlation with TP53 mutation status. | p53 immunohistochemistry has long been proposed for the separation of benign from malignant mesothelial proliferations, with the older literature suggesting that any degree of positivity supported a diagnosis of mesothelioma. However, using modern immunohistochemistry platforms in other organ systems, notably gynecolog... | 10.1038/s41379-021-00920-9 | 34,497,363 | D014408:Biomarkers, Tumor; D015331:Cohort Studies; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma; D009154:Mutation; D012189:Retrospective Studies; D046888:Tissue Array Analysis | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 2,022 | D014408:Biomarkers, Tumor |
Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients who could not receive methotrexate: 52-week results from an open-label extension of the HIKARI study. | OBJECTIVES
To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients who could not receive methotrexate (MTX).
METHODS
HIKARI double-blind (DB) patients were entered into an open... | 10.3109/14397595.2013.865822 | 24,372,225 | D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D001172:Arthritis, Rheumatoid; D001175:Arthrography; D000068582:Certolizumab Pegol; D018450:Disease Progression; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D00714... | Modern rheumatology | 2,014 | D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D007140:Immunoglobulin Fab Fragments; D011092:Polyethylene Glycols; D000068582:Certolizumab Pegol |
Preparing size markers for gel electrophoresis. | Here we present two simple methods for preparing radiolabeled size markers for gel electrophoresis. The first procedure describes the generation of an RNA marker ladder by the alkaline hydrolysis of (32)P 5'- or 3'-end-labeled RNA. The second procedure describes the labeling of DNA fragments produced by digestion of pB... | 24,298,031 | D004247:DNA; D004586:Electrophoresis; D007553:Isotope Labeling; D008970:Molecular Weight; D012313:RNA; D012015:Reference Standards | Cold Spring Harbor protocols | 2,013 | D012313:RNA; D004247:DNA | |
Cryo-EM Resolves Molecular Recognition Of An Optojasp Photoswitch Bound To Actin Filaments In Both Switch States. | Actin is essential for key processes in all eukaryotic cells. Cellpermeable optojasps provide spatiotemporal control of the actin cytoskeleton, confining toxicity and potentially rendering F-actin druggable by photopharmacology. Here, we report cryo electron microscopy (cryo-EM) structures of both isomeric states of on... | 10.1002/anie.202013193 | 33,449,370 | D008841:Actin Cytoskeleton; D000199:Actins; D001391:Azo Compounds; D020285:Cryoelectron Microscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D055668:Photochemical Processes | Angewandte Chemie (International ed. in English) | 2,021 | D000199:Actins; D001391:Azo Compounds; C009850:azobenzene |
Molecular identification and osmotolerant profile of wine yeasts that ferment a high sugar grape must. | The objective of this study was to examine the Saccharomyces and non-Saccharomyces yeast populations involved in a spontaneous fermentation of a traditional high sugar must (Vino cotto) produced in central Italy. Molecular identification of a total of 78 isolates was achieved by a combination of PCR-RFLP of the 5.8S IT... | 10.1016/j.ijfoodmicro.2009.01.024 | 19,230,999 | D050260:Carbohydrate Metabolism; D002241:Carbohydrates; D005285:Fermentation; D019649:Food Industry; D007700:Kinetics; D009994:Osmolar Concentration; D010802:Phylogeny; D027843:Vitis; D014867:Water; D014920:Wine; D015003:Yeasts | International journal of food microbiology | 2,009 | D002241:Carbohydrates; D014867:Water |
Investigating Factors Associated with Depressive Symptoms of Chronic Kidney Diseases in China with Type 2 Diabetes. | Aim. To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms. Methods. In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong Univer... | 10.1155/2017/1769897 | 28,261,621 | D000368:Aged; D002681:China; D003430:Cross-Sectional Studies; D003863:Depression; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D051436:Renal Insufficiency, Chronic; D012307:Risk Factors; D012737:Sex ... | Journal of diabetes research | 2,017 | |
Sub-clinical compulsive checkers show impaired performance on habitual, event- and time-cued episodic prospective memory tasks. | This study focused on examining whether sub-clinical checkers perform worse on a behavioral measure of habitual prospective memory, and on uncovering the source of a dissociation we previously reported between sub-clinical checkers' performance on event- and time-cued episodic prospective memory tasks [Cuttler, C., & G... | 10.1016/j.janxdis.2009.03.006 | 19,394,193 | D000293:Adolescent; D000328:Adult; D003192:Compulsive Behavior; D003463:Cues; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders; D008875:Middle Aged; D008960:Models, Psychological; D009771:Obsessive-Compulsive Disorder; D010555:Personality Inventory; D012720:Severity of Illness Inde... | Journal of anxiety disorders | 2,009 | |
miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury. | Exosomes have been shown to effectively regulate the biological functions of target cells. Here, we investigated the protective effect and mechanism of hypoxia-induced renal tubular epithelial cells (TECs)-derived exosomes on acute tubular injury. We found that in vitro hypoxia-induced tubular exosomes (Hy-EXOs) were p... | 10.1042/CS20200288 | 32,808,649 | D058186:Acute Kidney Injury; D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D004847:Epithelial Cells; D055354:Exosomes; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia; D007687:Kidney Tubules, Proximal; D008297:Male; D008810:Mice, Inbred C57BL; D035683:MicroRNAs; D046529:Microsc... | Clinical science (London, England : 1979) | 2,020 | D035683:MicroRNAs; C532375:Mirn20 microRNA, mouse; D017382:Reactive Oxygen Species |
[Virtual surgical planning in liver surgery]. | UNLABELLED
The operability of a liver tumour depends on its three-dimensional relation to the intrahepatic vascular trees which define autonomously functioning liver (sub-)segments. The aim of our study was to establish a computer-based three-dimensional volumetric operation planning system for the liver.
METHODS
Usi... | 10.1007/s001040050637 | 10,230,534 | D000465:Algorithms; D001185:Artificial Intelligence; D005103:Expert Systems; D006498:Hepatectomy; D006499:Hepatic Artery; D006503:Hepatic Veins; D006801:Humans; D008113:Liver Neoplasms; D010347:Patient Care Planning; D012680:Sensitivity and Specificity; D012984:Software; D014057:Tomography, X-Ray Computed; D014584:User... | Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen | 1,999 | |
Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens. | The repeated administration of cocaine produces enduring neuroadaptations that are associated with enhanced behavioral responsiveness to cocaine administration and lead to cocaine addiction and the manifestation of paranoid psychosis. This review describes the effect of chronic cocaine administration on dopamine and gl... | 10.1300/J069v20n03_05 | 11,681,592 | D000222:Adaptation, Physiological; D000818:Animals; D001522:Behavior, Animal; D003042:Cocaine; D004298:Dopamine; D018698:Glutamic Acid; D008958:Models, Molecular; D009714:Nucleus Accumbens | Journal of addictive diseases | 2,001 | D018698:Glutamic Acid; D003042:Cocaine; D004298:Dopamine |
Laboratory evaluation of magnesium status. Renal function and free intracellular magnesium concentration. | In summary, magnesium plays an essential role in both extracellular and intracellular metabolism. Even though biologists recognize the importance of magnesium, clinicians often are unaware of the frequency and significance of magnesium disturbances. Some clinicians recommend routine measurement of magnesium when other ... | 8,462,261 | D006801:Humans; D007668:Kidney; D008274:Magnesium; D014018:Tissue Distribution | Clinics in laboratory medicine | 1,993 | D008274:Magnesium | |
Comprehensive language mapping in children, using functional magnetic resonance imaging: what's missing counts. | Noninvasive language mapping is a frequently used application of functional magnetic resonance imaging. The examination of children, however, poses both practical and technical challenges. To this effect, we have developed two new paradigms mainly requiring passive listening to stories from which several key words were... | 10.1097/00001756-200506210-00008 | 15,931,061 | D000293:Adolescent; D001921:Brain; D001931:Brain Mapping; D002648:Child; D032882:Comprehension; D004292:Dominance, Cerebral; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008297:Male; D010100:Oxygen; D014705:Verbal Behavior | Neuroreport | 2,005 | D010100:Oxygen |
Prevalence and risk factors of axial neck pain in patients undergoing multilevel anterior cervical decompression with fusion surgery. | OBJECTIVES
The aim of this study was to explore the prevalence and risk factors for axial neck pain in patients undergoing multilevel anterior cervical decompression with fusion surgery.
METHODS
In this study, 88 patients, who underwent multilevel anterior cervical decompression with fusion surgery from January 2012 ... | 10.1186/s13018-019-1132-y | 30,947,714 | D000368:Aged; D002574:Cervical Vertebrae; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007738:Kyphosis; D008297:Male; D008875:Middle Aged; D019547:Neck Pain; D010147:Pain Measurement; D010149:Pain, Postoperative; D011859:Radiography; D012189:Retrospective Studies; D012307... | Journal of orthopaedic surgery and research | 2,019 | |
Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention. | BACKGROUND
Dopamine receptors are involved in midbrain reward circuit activation. Polymorphisms in two dopamine receptor genes, DRD2 and DRD4, have been associated with altered perception of food reward and weight gain. The objective of this study was to determine whether the same risk alleles were associated with over... | 10.1186/1471-2431-13-197 | 24,283,216 | D000293:Adolescent; D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018598:Minisatellite Repeats; D009765:Obesity; D050177:Overweight; D011110:Polymorphism, Genetic; D0206... | BMC pediatrics | 2,013 | D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4 |
Adaptation to disability in chronic obstructive pulmonary disease: neglected relationships to older adults' perceptions of independence. | PURPOSE
This study extends understanding of the relationship between disability and independence in older adults with COPD.
METHODS
An interviewer-administered questionnaire was used to examine disability, adaptation, perceptions of independence, and self-efficacy in a sample of 50 community-dwelling older adults. Od... | 10.1080/0963828031000093495 | 12,959,360 | D000203:Activities of Daily Living; D000223:Adaptation, Psychological; D000368:Aged; D001294:Attitude to Health; D002170:Canada; D006233:Disabled Persons; D005260:Female; D006801:Humans; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive; D011795:Surveys and Questionnaires | Disability and rehabilitation | 2,003 | |
Genetic determinants of IL-6 expression levels do not influence bone loss in inflammatory bowel disease. | Bone loss in inflammatory bowel disease (IBD) is presumed to be mediated by inflammation. Increased levels of the multifunctional cytokine IL-6 in inflammatory diseases have been proposed to be the link in such "inflammation-mediated osteopenia." A recently described G/C polymorphism with an effect on transcription rat... | 10.1023/a:1012300609279 | 11,713,964 | D000328:Adult; D015519:Bone Density; D001842:Bone and Bones; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015212:Inflammatory Bowel Diseases; D015850:Interleukin-6; D008297:Male; D010024:Osteoporosis; D011110:Polymorphism, Genetic; D0139... | Digestive diseases and sciences | 2,001 | D015850:Interleukin-6 |
Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells. | Lycopene is a natural pigment synthesized by plants and microorganisms, and it is mainly found in tomatoes. It is an acyclic isomer of beta-carotene and one of the most potent antioxidants. Several studies have demonstrated the ability of lycopene to prevent chemically induced DNA damage; however, the mechanisms involv... | 10.1016/j.tiv.2007.01.020 | 17,350,795 | D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D016587:Antimutagenic Agents; D016466:CHO Cells; D002338:Carotenoids; D019457:Chromosome Breakage; D020552:Comet Assay; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA; D004249:DNA Damage; D006861:Hydrogen Peroxide; D000077276:Lycopene; D008741:Methyl Methanesulfon... | Toxicology in vitro : an international journal published in association with BIBRA | 2,007 | D016587:Antimutagenic Agents; D009153:Mutagens; D002338:Carotenoids; D015112:4-Nitroquinoline-1-oxide; D004247:DNA; D008741:Methyl Methanesulfonate; D006861:Hydrogen Peroxide; D000077276:Lycopene |
Endothelial Cell Autophagy Maintains Shear Stress-Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase. | OBJECTIVE
Impaired endothelial cell (EC) autophagy compromises shear stress-induced nitric oxide (NO) generation. We determined the responsible mechanism.
APPROACH AND RESULTS
On autophagy compromise in bovine aortic ECs exposed to shear stress, a decrease in glucose uptake and EC glycolysis attenuated ATP production... | 10.1161/ATVBAHA.117.309510 | 28,684,613 | D000255:Adenosine Triphosphate; D000818:Animals; D001343:Autophagy; D000071183:Autophagy-Related Proteins; D002417:Cattle; D002478:Cells, Cultured; D042783:Endothelial Cells; D051272:Glucose Transporter Type 1; D006019:Glycolysis; D006801:Humans; D040542:Mechanotransduction, Cellular; D008810:Mice, Inbred C57BL; D01834... | Arteriosclerosis, thrombosis, and vascular biology | 2,017 | D000071183:Autophagy-Related Proteins; D051272:Glucose Transporter Type 1; D047428:Protein Kinase Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D017382:Reactive Oxygen Species; D058472:Receptors, Purinergic P2Y1; D009569:Nitric Oxide; D012694:Serine; D000255:Adenosine Triphosphate; D052250:Nitric Oxide Synth... |
[Late gestoses complicated by amaurosis]. | A case of amaurosis in the course of preeclampsia and one in eclampsia are presented. Since in both cases conservative therapy failed, the cesarean section was applied in both cases. The infants were of low birth weight but developed well. Amaurosis in both patients disappeared a few days after delivery. In such cases ... | 1,027,932 | D000328:Adult; D001766:Blindness; D002585:Cesarean Section; D004461:Eclampsia; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011225:Pre-Eclampsia; D011247:Pregnancy; D012075:Remission, Spontaneous | Jugoslavenska ginekologija i opstetricija | 1,976 | ||
Recurrent cementifying fibroma of the maxilla: report of case. | A case of recurrent cementifying fibroma of the maxilla has been presented. When the lesion was excised in 1948, it was reportedly well delineated from surrounding bone. There was no delineation of the tumor from the surrounding bone at the time of the operation in 1972. | 264,523 | D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms; D008443:Maxillary Sinus; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors | Journal of oral surgery (American Dental Association : 1965) | 1,977 | ||
Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats. | The study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor... | 10.1007/s12011-021-03065-7 | 35,034,263 | D000818:Animals; D001170:Arthritis, Infectious; D001888:Boric Acids; D002437:Cefazolin; D000071063:Endoglin; D004926:Escherichia coli; D004927:Escherichia coli Infections; D008233:Lymphotoxin-alpha; D051379:Mice; D051381:Rats | Biological trace element research | 2,022 | D001888:Boric Acids; D000071063:Endoglin; D008233:Lymphotoxin-alpha; D002437:Cefazolin; C032688:boric acid |
CVA (cerebrovascular accident) pathway cuts across seven hospital units. | After discovering that stroke patients were receiving care on 18 different units within the hospital, St. Luke's Medical Center in Milwaukee developed its first cross-unit clinical pathway, targeted at cerebrovascular accident (CVA) patients. Implemented in October 1996, the five-day CVA pathway has cut length of stay ... | 10,177,973 | D002561:Cerebrovascular Disorders; D019091:Critical Pathways; D006757:Hospital Units; D006801:Humans; D007902:Length of Stay; D009720:Nurse Clinicians; D010353:Patient Education as Topic; D018802:Patient-Centered Care; D014922:Wisconsin | Hospital case management : the monthly update on hospital-based care planning and critical paths | 1,998 | ||
Current advances in therapies for calcium pyrophosphate crystal arthritis. | PURPOSE OF REVIEW
Calcium pyrophosphate (CPP) crystal disease is a common rheumatologic disorder that has received limited attention from the scientific community. This review is aimed at summarizing current evidence for managing CPP disease (CPPD), focusing on recently reported advances.
RECENT FINDINGS
New data fro... | 10.1097/BOR.0000000000000252 | 26,780,424 | D018501:Antirheumatic Agents; D001168:Arthritis; D001688:Biological Products; D002131:Calcium Pyrophosphate; D002805:Chondrocalcinosis; D003460:Crystallization; D005938:Glucocorticoids; D006801:Humans; D053583:Interleukin-1beta; D008727:Methotrexate | Current opinion in rheumatology | 2,016 | D018501:Antirheumatic Agents; D001688:Biological Products; D005938:Glucocorticoids; D053583:Interleukin-1beta; D002131:Calcium Pyrophosphate; D008727:Methotrexate |
Oral antibiotics for perforated appendicitis is not recommended. | In the majority of surgical departments in Denmark, the postoperative treatment for acute perforated appendicitis comprises three days of intravenous antibiotics. Recently, it has been proposed that such antibiotic regimen should be replaced by orally administered antibiotics. The aim of this paper was to give an overv... | 20,816,017 | D000284:Administration, Oral; D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis; D001062:Appendectomy; D001064:Appendicitis; D006801:Humans; D007262:Infusions, Intravenous | Danish medical bulletin | 2,010 | D000900:Anti-Bacterial Agents | |
Hydroponic Treatment of Nicotiana benthamiana with Kifunensine Modifies the N-glycans of Recombinant Glycoprotein Antigens to Predominantly Man9 High-Mannose Type upon Transient Overexpression. | Nicotiana benthamiana transient overexpression systems offer unique advantages for rapid and scalable biopharmaceuticals production, including high scalability and eukaryotic post-translational modifications such as N-glycosylation. High-mannose-type glycans (HMGs) of glycoprotein antigens have been implicated in the e... | 10.3389/fpls.2018.00062 | 29,441,088 | Frontiers in plant science | 2,018 | ||
Preterm Birth, Kidney Function and Cardiovascular Disease in Children and Adolescents. | Over recent decades, there has been a global increase in preterm birth rate, which constitutes about 11% of total births worldwide. The present review aims to summarize the current knowledge on the long-term consequences of prematurity on renal and cardiovascular development and function. Recent literature supports tha... | 10.3390/children9081130 | 36,010,021 | Children (Basel, Switzerland) | 2,022 | ||
Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae in vitro. | Multiple studies report apparent effects of vanadium on various systems in vivo and in vitro. Vanadium species may be possible deterrents for the growth of the Leishmania parasite, which causes the sometimes deadly diseases known as leishmaniasis. The current studies focus specifically on decavanadate V(10)O(28)(6-) (V... | 10.1016/j.jinorgbio.2011.09.009 | 22,005,446 | D000135:Acid Phosphatase; D000469:Alkaline Phosphatase; D000818:Animals; D000981:Antiprotozoal Agents; D002417:Cattle; D018360:Crystallography, X-Ray; D004789:Enzyme Activation; D007093:Imidazoles; D007891:Leishmania; D010736:Phosphoglycerate Mutase; D010848:Picolinic Acids; D054562:Protein Tyrosine Phosphatase, Non-Re... | Journal of inorganic biochemistry | 2,012 | D000981:Antiprotozoal Agents; D007093:Imidazoles; D010848:Picolinic Acids; D017968:Vanadium Compounds; D062367:ortho-Aminobenzoates; D014639:Vanadium; C031385:anthranilic acid; D014638:Vanadates; C029899:imidazole; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D054562:Protein Tyrosine Phosphatase, Non-Recepto... |
In vitro drug resistance in acute myeloid and chronic B-lymphocytic leukaemic blasts and in normal blood and marrow populations. | The sensitivities of AML and BCLL blasts to daunorubicin have been determined, using an in vitro (MTT) assay of resistance, and compared with the sensitivities of normal haemopoietic populations and cells of the multidrug-resistant, T-lymphoid line CEM VLB100; The role of the drug-efflux pump, P-glycoprotein, was deter... | 10.1016/0145-2126(94)90068-x | 7,934,144 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001752:Blast Crisis; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002470:Cell Survival; D002478:Cells, Cultured; D016572:Cyclosporine; D003630:Daunorubicin; D004351:Drug R... | Leukemia research | 1,994 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D016572:Cyclosporine; D015255:Idarubicin; D003630:Daunorubicin |
Brain tissue oxygenation during dexmedetomidine administration in surgical patients with neurovascular injuries. | Investigations in dogs have shown substantial dexmedetomidine (Dex)-induced reductions in cerebral blood flow (CBF) unaccompanied by reductions in cerebral metabolic rate (CMR). If this effect were to occur in humans in areas of injured brain in which CBF is already low, oxygen delivery might be critically impaired. Th... | 10.1097/ANA.0b013e3181e4b7e3 | 20,622,684 | D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001923:Brain Chemistry; D002561:Cerebrovascular Disorders; D016208:Databases, Factual; D020927:Dexmedetomidine; D005260:Female; D006339:Heart Rate; D006801:Humans; D006993:Hypnotics and Sedatives; D002538:Intracranial Arteriovenous Malformations; D008297:Male; D0088... | Journal of neurosurgical anesthesiology | 2,010 | D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine |
Estimation of reliability in a three-factor model. | Reliability measures have been well studied over many years. Such measures have been thoroughly studied for two-factor models. Motivated by a medical research problem, point and confidence interval estimates of the intraclass correlation coefficient are extended to models containing three crossed random factors-subject... | 10.1002/sim.4182 | 21,290,406 | D000704:Analysis of Variance; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D008390:Markov Chains; D015233:Models, Statistical; D009010:Monte Carlo Method; D015203:Reproducibility of Results | Statistics in medicine | 2,011 | |
[Alcohol and epilepsy: a case report between alcohol withdrawal seizures and neuroborreliosis]. | OBJECTIVES
This work consists in a study of the links between alcohol, a psychoactive substance and different related epileptic manifestations in order to clarify predominant factors both on conceptual, clinical and therapeutic levels.
BACKGROUND
If alcohol is a frequent risk factor for seizures, its scientific evide... | 10.1016/j.encep.2010.10.004 | 21,703,439 | D020270:Alcohol Withdrawal Seizures; D019973:Alcohol-Related Disorders; D000435:Alcoholic Intoxication; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic; D006801:Humans; D020852:Lyme Neuroborreliosis; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D0120... | L'Encephale | 2,011 | |
Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System. | A novel glucose (Glc)-responsive gel formed by worm-like micelles (WLMs) has the potential to provide a self-regulating insulin delivery system. We have prepared a WLM gel system using 75 mM cetyltrimethylammonium bromide, 75 mM phenylboronic acid, and water. At pH 9.4, this gel-like system was highly viscous and suppo... | 10.1021/acs.molpharmaceut.7b00988 | 29,411,982 | D001786:Blood Glucose; D001897:Boronic Acids; D000077286:Cetrimonium; D003911:Dextrans; D016503:Drug Delivery Systems; D065546:Drug Liberation; D016650:Fluorescein-5-isothiocyanate; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007003:Hypoglycemia; D007004:Hypoglycemic Agents; D007328:Insulin; D008... | Molecular pharmaceutics | 2,018 | D001786:Blood Glucose; D001897:Boronic Acids; D003911:Dextrans; D005782:Gels; D007004:Hypoglycemic Agents; D007328:Insulin; D008823:Micelles; C015219:fluorescein isothiocyanate dextran; D014867:Water; D016650:Fluorescein-5-isothiocyanate; C010686:benzeneboronic acid; D000077286:Cetrimonium |
Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3. | Circadian rhythms are a very exquisite mechanism to influence on transcriptional levels and physiological activities of various molecules that affect cell metabolic pathways. Long-term alteration of circadian rhythms increases the risk of cardiovascular diseases, hypertension, hypertriglyceridemia, and metabolic syndro... | 10.3389/fimmu.2020.552188 | 33,013,924 | D050976:Basic-Leucine Zipper Transcription Factors; D002940:Circadian Rhythm; D000069196:Gastrointestinal Microbiome; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension; D015228:Hypertriglyceridemia; D024821:Metabolic Syndrome | Frontiers in immunology | 2,020 | D050976:Basic-Leucine Zipper Transcription Factors; C497440:NFIL3 protein, human |
Minimal physicalism as a scale-free substrate for cognition and consciousness. | Theories of consciousness and cognition that assume a neural substrate automatically regard phylogenetically basal, nonneural systems as nonconscious and noncognitive. Here, we advance a scale-free characterization of consciousness and cognition that regards basal systems, including synthetic constructs, as not only in... | 10.1093/nc/niab013 | 34,345,441 | Neuroscience of consciousness | 2,021 | ||
Neonatal presentation of cystic fibrosis requiring ECMO. | This is a case of cystic fibrosis causing respiratory distress in a newborn who was treated successfully with extracorporeal membrane oxygenation (ECMO). To date, this is the only such case reported to the Neonatal ECMO Registry at the University of Michigan. ECMO can be a life-saving intervention in these neonates. Ad... | 10.1016/0022-3468(91)90438-y | 2,005,536 | D003550:Cystic Fibrosis; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D012127:Respiratory Distress Syndrome, Newborn | Journal of pediatric surgery | 1,991 | |
BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration. | BETA2/NeuroD1 is a basic helix-loop-helix transcription factor that is expressed widely throughout the developing nervous system. Previous studies have shown that BETA2/NeuroD1 influences the fate of retinal cells in culture. To analyze the effect of BETA2/NeuroD1 on the structure and function of the retina, we examine... | 12,533,605 | D000818:Animals; D017209:Apoptosis; D051792:Basic Helix-Loop-Helix Transcription Factors; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D018450:Disease Progression; D004596:Electroretinography; D017930:Genes, Reporter; D006720:Homozygote; D007150:Immunohistochemistry; D0202... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,003 | D051792:Basic Helix-Loop-Helix Transcription Factors; D004268:DNA-Binding Proteins; C501008:Neurod1 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors | |
The Brassicaceae species Heliophila coronopifolia produces root border-like cells that protect the root tip and secrete defensin peptides. | Background and Aims
Root border cells and border-like cells (BLCs), the latter originally described in Arabidopsis thaliana , have been described as cells released at the root tips of the species in which they occur. BLCs are thought to provide protection to root meristems similar to classical root border cells. In add... | 10.1093/aob/mcw141 | 27,481,828 | D019607:Brassicaceae; D023082:Defensins; D018519:Meristem; D008856:Microscopy, Fluorescence; D010940:Plant Proteins; D018517:Plant Roots; D060888:Real-Time Polymerase Chain Reaction | Annals of botany | 2,017 | D023082:Defensins; D010940:Plant Proteins |
Exposure evaluation to airborne polycyclic aromatic hydrocarbons in an italian airport. | The aim of this study was to use environmental monitoring to evaluate occupational exposure to polycyclic aromatic hydrocarbons (PAHs) and biphenyl in an Italian airport. Air was sampled using a quartz fiber filter, a polyurethane foam, and an XAD-2 layer. After extraction with dichloromethane, concentration and purifi... | 10.1097/01.jom.0000218692.37154.0b | 16,902,374 | D000393:Air Pollutants; D001359:Aviation; D004784:Environmental Monitoring; D007558:Italy; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke | Journal of occupational and environmental medicine | 2,006 | D000393:Air Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke |
Development of the human principal inferior olivary nucleus: A morphometric and computerized 3D-reconstruction study. | INTRODUCTION
This study describes the prenatal development of the principal inferior olivary nucleus (PO) in humans.
MATERIAL/METHODS
Ten brains were obtained from preterm infants aged 21-43 postmenstrual weeks (PW). After fixation, the brains were processed into 30-μm serial sections, which were stained using the Kl... | 10.1016/j.neulet.2019.134302 | 31,152,849 | D002452:Cell Count; D005865:Gestational Age; D006801:Humans; D021621:Imaging, Three-Dimensional; D007234:Infant, Premature; D009474:Neurons; D009847:Olivary Nucleus | Neuroscience letters | 2,019 | |
Plasma-activated water: A novel frozen meat thawing media for reducing microbial contamination on chicken and improving the characteristics of protein. | To solve the problems of microbial contamination and protein loss caused by the conventional thawing method, plasma-activated water (PAW) and ultrasound were applied. Changes in microorganisms, protein loss, oxidation, degradation, digestion, and lipid oxidation were measured to evaluate the practicability of novel tha... | 10.1016/j.foodchem.2021.131661 | 34,863,602 | D000818:Animals; D002645:Chickens; D003470:Culture Media; D005615:Freezing; D008460:Meat; D014867:Water | Food chemistry | 2,022 | D003470:Culture Media; D014867:Water |
nRIP-seq: a technique to identify RNA targets of an RNA binding protein on a genome-wide scale. | Native RNA immunoprecipitation (nRIP) coupled with high-throughput sequencing (nRIP-seq) is a powerful technique that allows transcriptome-wide identification of the entire subset of coding and noncoding RNAs associated with a particular protein. Since this technology is carried out in a native condition without cross-... | 10.1007/978-1-4939-1369-5_9 | 25,240,890 | D000818:Animals; D053595:Embryonic Stem Cells; D015723:Gene Library; D059014:High-Throughput Nucleotide Sequencing; D047468:Immunoprecipitation; D051379:Mice; D063146:Polycomb-Group Proteins; D016133:Polymerase Chain Reaction; D012313:RNA; D016601:RNA-Binding Proteins | Methods in molecular biology (Clifton, N.J.) | 2,015 | D063146:Polycomb-Group Proteins; D016601:RNA-Binding Proteins; D012313:RNA |
Short-course antimicrobial therapy of streptococcal pharyngitis. | While penicillin administered orally or intramuscularly is the least expensive course of pharyngitis treatment, there are many limitations to its use. These include the need for extended treatment (i.e., 10 days) and poor palatability of its liquid formulation and an alarming increase in the rates of failure with stand... | 10.1177/000992280304200801 | 14,601,914 | D002648:Child; D006801:Humans; D010404:Penicillin V; D010612:Pharyngitis; D012008:Recurrence; D013290:Streptococcal Infections; D013297:Streptococcus pyogenes; D016896:Treatment Outcome | Clinical pediatrics | 2,003 | D010404:Penicillin V |
Cellular internalisation of Clostridium difficile toxin A. | The cytopathogenic effect of toxin A from Clostridium difficile was studied in cultured human lung fibroblasts. The final effect was dependent on toxin concentration and exposure time. Binding of the toxin to cells occurred at 0 degrees C as well as at 37 degrees C. The latency before appearance of the cytopathogenic e... | 10.1016/0882-4010(87)90052-0 | 3,148,814 | D000818:Animals; D001427:Bacterial Toxins; D001593:Benzyl Compounds; D002460:Cell Line; D002738:Chloroquine; D003013:Clostridium; D004768:Enterotoxins; D006801:Humans; D007700:Kinetics; D008985:Monensin; D011189:Potassium Chloride | Microbial pathogenesis | 1,987 | D001427:Bacterial Toxins; D001593:Benzyl Compounds; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; D011189:Potassium Chloride; C021292:benzyl chloride; D002738:Chloroquine; D008985:Monensin |
Effects of HCN channel blockade on the intensity‑response function of electroretinographic ON and OFF responses in dark adapted frogs. | Hyperpolarization‑activated and cyclic nucleotide‑gated (HCN) channels are well expressed in the vertebrate retina. Their role in formation of electroretinographic (ERG) responses to stimulus onset (b‑wave) and stimulus offset (d‑wave) are largely unknown. In this study we investigated the effects of pharmacological bl... | 32,602,859 | D000221:Adaptation, Ocular; D000818:Animals; D003623:Dark Adaptation; D006801:Humans; D010775:Photic Stimulation; D011743:Pyrimidines; D011895:Rana ridibunda; D012160:Retina | Acta neurobiologiae experimentalis | 2,020 | D011743:Pyrimidines; C082246:ICI D2788 | |
ROS and calcium oscillations are required for polarized root hair growth. | Root hairs are filamentous extensions from epidermis of plant roots with growth limited to the apical dome. Cell expansion undergoes tightly regulated processes, including the coordination between cell wall loosening and cell wall crosslinking, to form the final shape and size. Tip-focused gradients and oscillations of... | 10.1080/15592324.2022.2106410 | 35,938,584 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Transcription Factors; D002118:Calcium; D020013:Calcium Signaling; D002473:Cell Wall; D019255:NADPH Oxidases; D018517:Plant Roots; D017382:Reactive Oxygen Species | Plant signaling & behavior | 2,022 | D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Transcription Factors; C548371:RSL4 protein, Arabidopsis; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases; D002118:Calcium |
[Clinical observation of microsurgial repairing for the treatment of soft tissue defection of heel]. | OBJECTIVE
T o summarize the clinical effects of the repairing methods for skin and soft tissue defection of heel.
METHODS
From June 1998 to June 2009,42 patients with skin and soft tissue defection of heel underwent the repairing treatment,including 23 males and 19 females, with an average age of 37 years old ranging... | 25,739,255 | D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018409:Foot Injuries; D006365:Heel; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D017695:Soft Tissue Injuries; D013524:Surgical Flaps; D055815:Young Adult | Zhongguo gu shang = China journal of orthopaedics and traumatology | 2,014 | ||
Rapid detection of gammaT cell receptor gene rearrangements in acute lymphoblastic leukemia by electrophoresis and silver staining: implications for detection of minimal residual disease. | Minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) was studied using polymerase chain reaction (PCR). GammaT cell receptor (TCRG) genes are ideal targets for PCR-based detection of MRD due to their molecular characteristics. Polyacrylamide gel electrophoresis (PAGE) analysis of PCR products followed b... | 10.1002/elps.1150190831 | 9,694,286 | D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D018365:Neoplasm, Residual; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016622:Silver Staining; D013997:T... | Electrophoresis | 1,998 | D016692:Receptors, Antigen, T-Cell, gamma-delta |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database. | BACKGROUND
To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (≤ 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predictors of survival, recurrence and metastasis.
METHODS
A multi-institutional retrospective cohort stud... | 10.1186/s12894-020-00649-8 | 32,615,971 | D000368:Aged; D002292:Carcinoma, Renal Cell; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms; D007843:Latin America; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies; ... | BMC urology | 2,020 | |
Salubrinal Exposes Anticancer Properties in Inflammatory Breast Cancer Cells by Manipulating the Endoplasmic Reticulum Stress Pathway. | The endoplasmic reticulum (ER) regulates protein folding, post-translational modifications, lipid synthesis, and calcium signaling to attenuate the accumulation of misfolded proteins causing ER stress and maintains cellular homeostasis. The tumor microenvironment is rich in soluble cytokines, chemokines, growth, and an... | 10.3389/fonc.2021.654940 | 34,094,947 | Frontiers in oncology | 2,021 | ||
[Interventional treatment of heart failure : Stents and valves]. | The pharmacotherapy of heart failure has evolved in recent years and with the aid of new classes of drugs symptomatic and prognostic improvements can be achieved in patients with heart failure. Heart failure is particularly frequently associated with coronary artery disease or higher grade, often functional valve defec... | 10.1007/s00059-022-05160-4 | 36,700,948 | D006801:Humans; D006349:Heart Valve Diseases; D003324:Coronary Artery Disease; D001024:Aortic Valve Stenosis; D019918:Heart Valve Prosthesis Implantation; D006333:Heart Failure; D015607:Stents; D016896:Treatment Outcome | Herz | 2,023 | |
The Uncertain Certainty: A Mixed Methods Exploration of Personal Meanings of Death and Preliminary Insights Into Their Relationship With Worldview. | The present mixed methods study investigated personal meanings of death, i.e., concepts, views, and expectations associated with one's own death, and explored their relation to worldview. To this end, a sample of 202 young, German-speaking adults completed the Death Statements Test, a new qualitative assessment tool, a... | 10.1177/00302228231157135 | 36,779,858 | Omega | 2,023 | ||
Thrombotic risk in hereditary antithrombin III, protein C, or protein S deficiency. A cooperative, retrospective study. Gesellschaft fur Thrombose- und Hamostaseforschung (GTH) Study Group on Natural Inhibitors. | A cooperative, retrospective study was performed on data from 8 coagulation laboratories and thrombosis units in Austria, Germany, and Switzerland to assess the risk for thrombosis in patients with hereditary antithrombin III (AT-III), protein C (PC), and protein S (PS) deficiencies; to compare the clinical manifestati... | 10.1161/01.atv.16.6.742 | 8,640,401 | D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D020152:Antithrombin III Deficiency; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D020151:Pr... | Arteriosclerosis, thrombosis, and vascular biology | 1,996 | |
[Expression of autophagy-related protein Beclin-1 and microtubule-associated protein 2 light chain 3 in periodontal ligament cells in orthodontic tooth pressure areas]. | OBJECTIVE
To investigate the expression of autophagy-related protein Beclin-1 and microtubule-associated protein 2 light chain 3 (LC3Ⅱ) in periodontal ligament cells in orthodontic tooth pressure areas.
METHODS
Sixty male SD rats were randomly divided into a blank control group and nine experimental groups. In the ex... | 10.7518/hxkq.2019.02.008 | 31,168,983 | D000818:Animals; D001343:Autophagy; D000071186:Beclin-1; D008297:Male; D008869:Microtubule-Associated Proteins; D010010:Osteoclasts; D010513:Periodontal Ligament; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014087:Tooth Movement Techniques | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology | 2,019 | D000071186:Beclin-1; C512829:Becn1 protein, rat; D008869:Microtubule-Associated Proteins |
Schistosoma japonicum Infection Leads to the Reprogramming of Glucose and Lipid Metabolism in the Colon of Mice. | The deposition of Schistosoma japonicum (S. japonicum) eggs commonly induces inflammation, fibrosis, hyperplasia, ulceration, and polyposis in the colon, which poses a serious threat to human health. However, the underlying mechanism is largely neglected. Recently, the disorder of glucose and lipid metabolism was repor... | 10.3389/fvets.2021.645807 | 33,791,356 | Frontiers in veterinary science | 2,021 | ||
Primary care for persons with disabilities. The Boston, Massachusetts model program. | Boston's Community Medical Group (BCMG) was among the first primary care group practices to provide community-based continuous primary care to people with major disabling conditions, the first to rely on nurse-practitioners as primary care-givers, and one of the first to provide care on a prepaid capitated basis. With ... | 10.1097/00002060-199705001-00010 | 9,210,867 | D001900:Boston; D006233:Disabled Persons; D006279:Health Maintenance Organizations; D009722:Nurse Practitioners; D011320:Primary Health Care | American journal of physical medicine & rehabilitation | 1,997 | |
Dual effect of insulin on in vitro leptin secretion by adipose tissue. | Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (fr... | 10.1006/bbrc.2000.3506 | 11,027,500 | D000273:Adipose Tissue; D000368:Aged; D005260:Female; D015870:Gene Expression; D005947:Glucose; D006801:Humans; D007328:Insulin; D020738:Leptin; D008297:Male; D008875:Middle Aged; D009765:Obesity; D012333:RNA, Messenger | Biochemical and biophysical research communications | 2,000 | D007328:Insulin; D020738:Leptin; D012333:RNA, Messenger; D005947:Glucose |
Synthesis of none Bisphenol A structure dimethacrylate monomer and characterization for dental composite applications. | OBJECTIVE
In this study, new dimethacrylate monomer SiMA without Bisphenol A (BPA) structure was synthesized and used as base resin of dental composite materials with the aim of reducing human exposure to BPA derivatives.
METHODS
SiMA was synthesized through ring-opening addition reaction between 1,3-bis[2(3,4-epoxyc... | 24,950,804 | D000328:Adult; D001559:Benzhydryl Compounds; D002478:Cells, Cultured; D002766:Cholecystokinin; D003188:Composite Resins; D003764:Dental Materials; D006801:Humans; D008689:Methacrylates; D015394:Molecular Structure; D010446:Peptide Fragments; D010636:Phenols; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spect... | Dental materials : official publication of the Academy of Dental Materials | 2,014 | D001559:Benzhydryl Compounds; D003188:Composite Resins; D003764:Dental Materials; D008689:Methacrylates; D010446:Peptide Fragments; D010636:Phenols; C410885:cholecystokinin 8; D002766:Cholecystokinin; C006780:bisphenol A | |
Cooperative strand displacement by peptide nucleic acid (PNA). | BACKGROUND
Synthetic homopyrimidine peptide nucleic acids (PNAs) can bind complementary targets in double-stranded DNA, generating strand-displacement complexes, and so offering an opportunity to modulate specific gene expression. Several issues remain to be addressed before these attributes can be exploited in vivo, h... | 10.1016/s1074-5521(98)90142-9 | 9,495,832 | D004247:DNA; D018390:Gene Targeting; D007700:Kinetics; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides; D009994:Osmolar Concentration; D010455:Peptides; D011743:Pyrimidines; D014158:Transcription, Genetic | Chemistry & biology | 1,998 | D009838:Oligodeoxyribonucleotides; D010455:Peptides; D011743:Pyrimidines; D004247:DNA |
Prevalence and predictors of bias in the reporting of primary efficacy and toxicity endpoints in randomized clinical trials of radiation oncology. | INTRODUCTION
To determine the prevalence and predictors of bias in reporting of primary efficacy and toxicity endpoints in randomized trials (RCTs) of radiation oncology.
METHODS
We searched MEDLINE for eligible RCTs published from January 1994 to October 2014. Bias in reporting of primary efficacy endpoint was defin... | 10.1111/1754-9485.12494 | 27,396,237 | D015982:Bias; D006801:Humans; D008962:Models, Theoretical; D015995:Prevalence; D018787:Radiation Oncology; D016032:Randomized Controlled Trials as Topic; D012107:Research Design | Journal of medical imaging and radiation oncology | 2,016 | |
Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia. | BACKGROUND
Vascular dementia is the second most prevalent form of dementia. Hypertension is the leading risk factor for endothelial dysfunction and the progression of dementia that is of vascular origin. This study investigates the role of ulinastatin (UTI) and quercetin alone as well as in combination in hypertension-... | 10.1007/s43440-022-00364-1 | 35,396,697 | D000110:Acetylcholinesterase; D000818:Animals; D015140:Dementia, Vascular; D006023:Glycoproteins; D006973:Hypertension; D008297:Male; D018782:Maze Learning; D018384:Oxidative Stress; D011794:Quercetin; D051381:Rats | Pharmacological reports : PR | 2,022 | D006023:Glycoproteins; D011794:Quercetin; D000110:Acetylcholinesterase; C028665:urinastatin |
Predictors of CMV Infection in CMV-Seropositive Kidney Transplant Recipients: Impact of Pretransplant CMV-Specific Humoral Immunity. | BACKGROUND
Although cytomegalovirus (CMV)-seropositive solid organ transplant recipients have a relatively lower risk of CMV infection than CMV-seronegative recipients who receive allograft from CMV-seropositive donors, some patients remain at risk of CMV infection after transplant. We investigated the pretransplant CM... | 10.1093/ofid/ofab199 | 34,113,686 | Open forum infectious diseases | 2,021 | ||
Anticoagulation therapy and outcomes in patients with atrial fibrillation and serious mental illness: A systematic review and meta-analysis. | OBJECTIVE
A systematic review was conducted to investigate prevalence, management and outcomes of atrial fibrillation (AF) in people with Serious Mental Illnesses (SMI) versus the general population.
DATA SOURCES
MEDLINE, EMBASE, and PsycINFO were searched for primary research written in English and published between... | 10.1016/j.jpsychires.2022.11.002 | 36,417,811 | D006801:Humans; D001281:Atrial Fibrillation; D002545:Brain Ischemia; D020521:Stroke; D006470:Hemorrhage; D000925:Anticoagulants; D001523:Mental Disorders | Journal of psychiatric research | 2,022 | D000925:Anticoagulants |
Biting midges (Diptera: Ceratopogonidae) from an urban forest fragment in Central Amazon (Brazil): Effects of opening areas on abundance, richness, and composition. | We assessed the immature stages of Ceratopogonidae (Diptera) in artificial containers in an urban forest fragment in Manaus (Brazil), including their behavioral, biological and ecological information. In addition, we evaluated the effects of deforestation in an open and forested area on Ceratopogonidae communities. Imm... | 10.1590/0001-3765201720170370 | 29,236,855 | D000818:Animals; D059001:Aquatic Organisms; D001938:Brazil; D002519:Ceratopogonidae; D003247:Conservation of Natural Resources; D065928:Forests; D007303:Insect Vectors; D009032:Mosquito Control | Anais da Academia Brasileira de Ciencias | 2,017 | |
Human milk enriched with human milk lyophilisate for feeding very low birth weight preterm infants: A preclinical experimental study focusing on fatty acid profile. | BACKGROUND
Human milk, with essential nutrients and long chain polyunsaturated fatty acids (LC-PUFAs) such as the omega 3 and 6 fatty acids is important for development of the central nervous system and the retina in very low birth weight infants (<1,500 g). However, breast milk may not be sufficient to meet these need... | 10.1371/journal.pone.0202794 | 30,252,854 | D000293:Adolescent; D000328:Adult; D002849:Chromatography, Gas; D005227:Fatty Acids; D005260:Female; D005612:Freeze Drying; D006801:Humans; D007225:Infant Food; D041943:Infant Formula; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008055:Lipids; D008895:Milk, Human; D055815... | PloS one | 2,018 | D005227:Fatty Acids; D008055:Lipids |
CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans. | Graft-versus-host disease (GVHD) occurs in an unpredictable fashion after 30% to 50% of matched-related transplantations. The presence of increased frequencies of CD4(+)CD25(+) regulatory T cells in donor grafts has been shown to ameliorate GVHD after allogeneic transplantation in murine models. To determine whether a ... | 10.1182/blood-2003-06-2085 | 12,907,445 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002648:Child; D005260:Female; D006086:Graft vs Host Disease; D006650:Histocompatibility Testing; D006801:Humans; D018655:Lymphocyte Count; D008297:Male... | Blood | 2,004 | D015375:Receptors, Interleukin-2 |
The effect of ethnicity on different ways of expressing cardiovascular treatment benefits and patient decision-making. | INTRODUCTION
The way information is presented to communicate risk and treatment benefit affects patients' understanding and perception of their risk and can influence their decisions.
AIM
To assess the effect of ethnicity on patient preferences for different ways of expressing risk and treatment benefits.
METHODS
U... | 25,770,713 | D044466:Asian People; D002318:Cardiovascular Diseases; D003142:Communication; D003657:Decision Making; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D044468:Native Hawaiian or Other Pacific Islander; D010358:Patient Participation; D057240:Patient Preference; D011320:Primary Health Care; D018570:Risk ... | Journal of primary health care | 2,015 | ||
Genetic differentiation and estimation of effective population size and migration rates in two sympatric ecotypes of the marine snail Littorina saxatilis. | On exposed rocky shores in Galicia (northwest Spain), a striking polymorphism exists between two ecotypes (RB and SU) of Littorina saxatilis that occupy different levels of the intertidal zone and exhibit an incomplete reproductive isolation. The setting has been suggested to represent ongoing sympatric speciation by e... | 10.1093/jhered/esi064 | 15,843,633 | D000818:Animals; D017753:Ecosystem; D004641:Emigration and Immigration; D014644:Genetic Variation; D011156:Population Density; D012908:Snails | The Journal of heredity | 2,005 | |
A Novel Metastable Pentavalent Plutonium Solid Phase on the Pathway from Aqueous Plutonium(VI) to PuO2 Nanoparticles. | Here we provide evidence that the formation of PuO2 nanoparticles from oxidized PuVI under alkaline conditions proceeds through the formation of an intermediate PuV solid phase, similar to NH4 PuO2 CO3 , which is stable over a period of several months. For the first time, state-of-the-art experiments at Pu M4 and at L3... | 10.1002/anie.201911637 | 31,621,992 | Angewandte Chemie (International ed. in English) | 2,019 | ||
Uptake of core outcome sets by clinical trialists publishing in major medical journals: Protocol. | Background: Outcome heterogeneity, selective reporting, and choosing outcomes that do not reflect needs and priorities of stakeholders, limit the examination of health intervention effects, particularly in late phase trials. Core outcome sets (COS) are a proposed solution to these issues. A COS is an agreed-upon, stand... | 10.12688/hrbopenres.13109.2 | 33,693,308 | HRB open research | 2,020 | ||
Effects of family structure on children's use of ambulatory visits and prescription medications. | OBJECTIVE
To examine the effects of family structure, including number of parents, number of other children, and number and type of other adults, on office visits, emergency room visits, and use of prescription medications by children.
DATA SOURCE
The Household Component of the 1996-2001 Medical Expenditure Panel Sur... | 10.1111/j.1475-6773.2006.00584.x | 16,987,307 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D011307:Drug Prescriptions; D004363:Drug Utilization; D005191:Family Characteristics; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019458:Insurance Coverage; D007348:Insurance, Health; D008297:Male; D009819:... | Health services research | 2,006 | D004364:Pharmaceutical Preparations |
Mechanism of Pterostilbene-Induced Cell Death in HT-29 Colon Cancer Cells. | Pterostilbene is a dietary phytochemical that has been found to possess several biological activities, such as antioxidant and anti-inflammatory. Recent studies have shown that it exhibits the hallmark characteristics of an anticancer agent. The aim of the study was to investigate the anticancer activity of pterostilbe... | 10.3390/molecules27020369 | 35,056,682 | D013267:Stilbenes | Molecules (Basel, Switzerland) | 2,022 | D013267:Stilbenes |
["Memory-clinics" in German-speaking countries]. | This article gives an evaluation of the organization, diagnostics and offers of therapy from 41 memory-clinics conducted in German-speaking countries and shows that there is no uniform standard for the care of those suffering from dementia. As a result there are problems with quality assurance and financing. The survey... | 10.1007/s00391-003-0148-3 | 12,825,135 | D000368:Aged; D000544:Alzheimer Disease; D000554:Ambulatory Care Facilities; D001317:Austria; D003625:Data Collection; D003704:Dementia; D003937:Diagnosis, Differential; D015577:Geriatric Assessment; D005858:Germany; D006801:Humans; D007407:Interviews as Topic; D008569:Memory Disorders; D011594:Psychometrics; D011795:S... | Zeitschrift fur Gerontologie und Geriatrie | 2,003 | |
Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic and clinical implicati... | Free radical-catalysed oxidation of arachidonic acid esterified to lipids leads to the formation of the F(2)-isoprostane family which may theoretically comprise up to 64 isomers. We have previously shown that the combination of TLC and GC-tandem MS (referred to as method A) allows for the accurate and highly specific q... | 10.1016/s1570-0232(03)00457-4 | 12,954,376 | D000328:Adult; D016022:Case-Control Studies; D002846:Chromatography, Affinity; D002855:Chromatography, Thin Layer; D015237:Dinoprost; D028441:F2-Isoprostanes; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006973:Hypertension; D008055:Lipids; D008297:Male; D008875:Middle Aged; D015203:Re... | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | 2,003 | D028441:F2-Isoprostanes; D008055:Lipids; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost |
Counterion effects on fluorescence energy transfer in conjugated polyelectrolyte-based DNA detection. | Cationic poly[9,9'-bis[6''-(N,N,N-trimethylammonium)hexyl]fluorene-co-alt-phenylene]s with five different counterions (CIs) were synthesized and studied as fluorescence resonance energy transfer (FRET) donors (D) to dye-labeled DNA (FRET acceptor, A). The polymers with different CIs show the same pi-conjugated electron... | 10.1021/jp8107733 | 19,348,450 | D004247:DNA; D004573:Electrolytes; D005449:Fluorenes; D031541:Fluorescence Resonance Energy Transfer; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds | The journal of physical chemistry. B | 2,009 | D004573:Electrolytes; D005449:Fluorenes; D000644:Quaternary Ammonium Compounds; C541373:poly(9,9'-bis(6''-(N,N,N-trimethylammonium)hexyl)fluorene-co-alt-phenylene); D004247:DNA |
Assigning NMR spectra of RNA, peptides and small organic molecules using molecular network visualization software. | NMR assignment typically involves analysis of peaks across multiple NMR spectra. Chemical shifts of peaks are measured before being assigned to atoms using a variety of methods. These approaches quickly become complicated by overlap, ambiguity, and the complexity of correlating assignments among multiple spectra. Here ... | 10.1007/s10858-019-00271-3 | 31,325,088 | D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009930:Organic Chemicals; D010455:Peptides; D012313:RNA; D012984:Software | Journal of biomolecular NMR | 2,019 | D009930:Organic Chemicals; D010455:Peptides; D012313:RNA |
Interaction of the novel antipsychotic drug amperozide and its metabolite FG5620 with central nervous system receptors and monoamine uptake sites: relation to behavioral and clinical effects. | Behavioral, biochemical, and electrophysiological studies suggest that amperozide affects mesolimbic and mesocortical dopamine neurotransmission. The receptor binding profile of amperozide is discussed and related to behavioral and clinical, i.e., antipsychotic, effects of the drug. As previously reported, amperozide d... | 10.1016/S0006-3223(96)00117-5 | 9,270,901 | D000818:Animals; D014150:Antipsychotic Agents; D001522:Behavior, Animal; D001667:Binding, Competitive; D001923:Brain Chemistry; D002460:Cell Line; D002490:Central Nervous System; D004594:Electrophysiology; D066298:In Vitro Techniques; D007473:Ion Channels; D010879:Piperazines; D011869:Radioligand Assay; D051381:Rats; D... | Biological psychiatry | 1,997 | D014150:Antipsychotic Agents; C108541:FG 5620; D007473:Ion Channels; D010879:Piperazines; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C049058:amperozide |
Long-term results after aortic valve-sparing operation (David I). | OBJECTIVE
Aortic valve-sparing David procedure has gained broad acceptance. However, few long-term results have been published. We present our results.
METHODS
More than 450 David procedures have been performed in our institution so far. Of these, 126 patients were operated between July 1993 and December 2000. Median... | 10.1016/j.ejcts.2011.04.012 | 21,632,258 | D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection; D001011:Aorta; D001013:Aorta, Thoracic; D001014:Aortic Aneurysm; D001022:Aortic Valve Insufficiency; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implant... | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2,012 | |
The role of retinal photoisomerase in the visual cycle of the honeybee. | The compound eye of the honeybee has previously been shown to contain a soluble retinal photoisomerase which, in vitro, is able to catalyze stereospecifically the photoconversion of all-trans retinal to 11-cis retinal. In this study we combine in vivo and in vitro techniques to demonstrate how the retinal photoisomeras... | 10.1085/jgp.97.1.143 | 2,007,885 | D000221:Adaptation, Ocular; D000426:Alcohol Dehydrogenase; D000818:Animals; D001516:Bees; D066298:In Vitro Techniques; D007536:Isomerism; D009895:Opsonin Proteins; D010775:Photic Stimulation; D010786:Photoreceptor Cells; D010857:Pigment Epithelium of Eye; D011894:Rana pipiens; D012160:Retina; D012176:Retinoids; D014020... | The Journal of general physiology | 1,991 | D009895:Opsonin Proteins; D012176:Retinoids; D014020:Tissue Extracts; D014801:Vitamin A; D000426:Alcohol Dehydrogenase |
Treatment outcomes in oropharynx cancer patients who did not complete planned curative radiotherapy. | PURPOSE
To evaluate outcomes in oropharyngeal cancer (OPC) patients who did not complete their planned curative radiation therapy (RT).
METHODS
OPC Patients who received less than planned curative RT dose between 2002 and 2016 were identified for analysis. HPV status was assessed. Radiation dose was normalized for fr... | 10.1016/j.oraloncology.2019.05.012 | 31,521,053 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms; D009960:Oropharynx; D030361:Papillom... | Oral oncology | 2,019 | |
RARbeta involvement in enhancement of lung tumor cell immunogenicity revealed by array analysis. | The retinoid receptors (RARs and RXRs) are mediators of the multiple effects of retinoic acid. Of these, the retinoic acid receptor beta2 (RARbeta2) has frequently been shown to be the principal mediator of the growth and tumor suppressive effects of retinoic acid; this gene is inactivated in many epithelial tumors and... | 10.1096/fasebj.14.9.1224 | 10,834,944 | D017209:Apoptosis; D002462:Cell Membrane; D002478:Cells, Cultured; D018920:Coculture Techniques; D015536:Down-Regulation; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D015395:Histocompatibility Antigens Class I; D006801:Human... | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2,000 | D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; C082925:retinoic acid receptor beta; D018799:Intercellular Adhesion Molecule-1 |
More Is Better: Recent Progress in Multi-Omics Data Integration Methods. | Multi-omics data integration is one of the major challenges in the era of precision medicine. Considerable work has been done with the advent of high-throughput studies, which have enabled the data access for downstream analyses. To improve the clinical outcome prediction, a gamut of software tools has been developed. ... | 10.3389/fgene.2017.00084 | 28,670,325 | Frontiers in genetics | 2,017 | ||
Chronic Chest Pain Control after Trans-Thoracic Biopsy in Mediastinal Lymphomas. | Chest pain following a trans-thoracic biopsy often has multiple etiologies, especially in patients with lymphomas. Pathological neuronal mechanisms integrate with an overproduction of IL-6, TNF-α, IL1-β by macrophages and monocytes, which amplifies inflammation and pain. In consideration of this complex pathogenesis, i... | 10.3390/healthcare9050589 | 34,069,774 | Healthcare (Basel, Switzerland) | 2,021 | ||
Sulfasalazine therapy for juvenile rheumatoid arthritis. | BACKGROUND AND PURPOSE
Sulfasalazine (SSZ) has recently been shown to be effective for the management of juvenile rheumatoid arthritis (JRA). This study investigated the efficacy and adverse effects of SSZ therapy in children with JRA.
METHODS
Data from the medical records of 24 children with JRA who were treated wit... | 12,099,201 | D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D001171:Arthritis, Juvenile; D001379:Azathioprine; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012460:Sulfasala... | Journal of the Formosan Medical Association = Taiwan yi zhi | 2,002 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D012460:Sulfasalazine; D001379:Azathioprine | |
Labor force participation and the influence of having back problems on income poverty in Australia. | STUDY DESIGN
Cross-sectional study of 45- to 64-year-old Australians.
OBJECTIVE
To assess the relationship between chronic back problems and being in income poverty among the older working-aged population.
SUMMARY OF BACKGROUND DATA
Older workers who leave the labor force due to chronic back problems have fragile e... | 10.1097/BRS.0b013e31824481ee | 22,166,931 | D000041:Absenteeism; D001315:Australia; D001415:Back; D002908:Chronic Disease; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D004651:Employment; D005260:Female; D006306:Health Surveys; D006801:Humans; D007182:Income; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; ... | Spine | 2,012 | |
Microstimulation of the human substantia nigra alters reinforcement learning. | Animal studies have shown that substantia nigra (SN) dopaminergic (DA) neurons strengthen action-reward associations during reinforcement learning, but their role in human learning is not known. Here, we applied microstimulation in the SN of 11 patients undergoing deep brain stimulation surgery for the treatment of Par... | 10.1523/JNEUROSCI.5445-13.2014 | 24,828,643 | D000368:Aged; D046690:Deep Brain Stimulation; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease; D011337:Probability Learning; D012054:Reinforcement, Psychology; D013378:Substantia Nigra | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,014 | |
Evaluation and management of heavy menstrual bleeding in adolescents: the role of the hematologist. | Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in the evaluation of such patients: 1) perform a clinical and laboratory evaluation for an underlying bleeding disorder based on the degree of clinical suspicion, 2) identify and manage any concomitant iron d... | 10.1182/blood-2018-05-848739 | 30,429,157 | D000293:Adolescent; D018798:Anemia, Iron-Deficiency; D005260:Female; D006405:Hematology; D006474:Hemorrhagic Disorders; D006801:Humans; D008595:Menorrhagia | Blood | 2,018 | |
Effects of a rework program in a university hospital and predictors of work restoration and maintenance in the participants. | During sickness absence, it appears necessary for psychiatric patients suffering from depression or bipolar disorder to undergo a psychiatric rehabilitation called the rework program that aids in work restoration and maintenance. However, few studies have investigated the effects of such a program and predictors of wor... | 10.3389/fpsyt.2022.944472 | 35,958,642 | Frontiers in psychiatry | 2,022 | ||
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. | Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that use 2 major pathways for antigen uptake: constitutive macropinocytosis and mannose receptor-mediated endocytosis. Efficient endocytosis is critical for DCs to fulfill their sentinel function in immunity. We investigated the influence of the imm... | 10.1182/blood.v100.3.1084 | 12,130,531 | D000818:Animals; D001854:Bone Marrow Cells; D018929:Cell Culture Techniques; D003713:Dendritic Cells; D004336:Drug Antagonism; D004705:Endocytosis; D007166:Immunosuppressive Agents; D037181:Lectins, C-Type; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D051379:Mice; D008810:Mice, Inbred C5... | Blood | 2,002 | D007166:Immunosuppressive Agents; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D020123:Sirolimus; D016559:Tacrolimus |
Muscular differentiation of chicken myotubes in a simple defined synthetic culture medium and in serum supplemented media: Expression of the molecular forms of acetylcholinesterase. | We attempted to cultivate muscle cells from chick embryos in a serum-free, defined medium similar to that proposed by Bottenstein and Sato (1979) for the growth and differentiation of a murine neuronal cell-line. (1) We found that muscle cells from the legs of 11-day old chick embryos can be cultivated in a medium cont... | 10.1016/0197-0186(86)90109-9 | 20,493,038 | Neurochemistry international | 1,986 | ||
Enhancing somatic nuclear reprogramming by Oct4 gain-of-function in cloned mouse embryos. | Cloned mouse embryo development to blastocyst stage correlates positively with the expression level of Oct4 (Pou5f1) at the morula stage, as reported previously by our laboratory. However, whether this correlation is based on a cause-effect relationship has remained unclear. To address this question, we artificially in... | 10.1387/ijdb.103197mp | 21,136,379 | D000818:Animals; D001755:Blastocyst; D002469:Cell Separation; D065150:Cellular Reprogramming; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009028:Morula; D053652:Nuclear Transfer... | The International journal of developmental biology | 2,010 | D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D012333:RNA, Messenger |
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