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Permeation risks with peracetic acid and hydrogen peroxide sterilizing agent inside ambulatory pumps. | The sterilizing agent commonly used to sterilize materials for an isolator is a peracetic acid (PA) and hydrogen peroxide (HP) mixture. The permeation of this agent through ambulatory pumps should reveal a potential toxic risk for the patient and a stability modification of the drug by a pH change. Six wrapped and six ... | 16,048,119 | D006861:Hydrogen Peroxide; D007260:Infusion Pumps; D008422:Materials Testing; D010463:Peracetic Acid; D010539:Permeability; D012306:Risk; D013242:Sterilization | PDA journal of pharmaceutical science and technology | 2,005 | D006861:Hydrogen Peroxide; D010463:Peracetic Acid | |
Functional cloning of genes that suppress oxidative stress-induced cell death: TCTP prevents hydrogen peroxide-induced cell death. | We used retroviral-mediated expression cloning to identify cDNAs that inhibit cell death induced by oxidative stress. To isolate the genes, we introduced a murine embryonic retroviral cDNA library into NIH/3T3 cells, and selected for cells resistant to hydrogen peroxide. The surviving cells were cloned, and the integra... | 10.1016/j.febslet.2009.03.045 | 19,328,788 | D000818:Animals; D001483:Base Sequence; D014408:Biomarkers, Tumor; D016923:Cell Death; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary; D006861:Hydrogen Peroxide; D051379:Mice; D041681:NIH 3T3 Cells; D018384:Oxidative Stress; D000090324:Tumor Protein, Translationally-Controlled 1 | FEBS letters | 2,009 | D014408:Biomarkers, Tumor; D017931:DNA Primers; D018076:DNA, Complementary; C000715648:Tpt1 protein, mouse; D000090324:Tumor Protein, Translationally-Controlled 1; D006861:Hydrogen Peroxide |
Q fever in Egypt: Epidemiological survey of Coxiella burnetii specific antibodies in cattle, buffaloes, sheep, goats and camels. | Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Clinical presentation in humans varies from asymptomatic to flu-like illness and severe sequelae may be seen. Ruminants are often sub-clinically infected or show reproductive disorders such as abortions. In Egypt, only limited data on the epidemio... | 10.1371/journal.pone.0192188 | 29,466,380 | D000818:Animals; D000907:Antibodies, Bacterial; D002020:Buffaloes; D002162:Camelus; D002417:Cattle; D004534:Egypt; D004797:Enzyme-Linked Immunosorbent Assay; D006041:Goats; D011778:Q Fever; D016036:Seroepidemiologic Studies; D012756:Sheep; D015047:Zoonoses | PloS one | 2,018 | D000907:Antibodies, Bacterial |
Prevalence of BTK and PLCG2 mutations in a real-life CLL cohort still on ibrutinib after 3 years: a FILO group study. | Mutational analyses performed following acquired ibrutinib resistance have suggested that chronic lymphocytic leukemia (CLL) progression on ibrutinib is linked to mutations in Bruton tyrosine kinase (BTK) and/or phospholipase Cγ2 (PLCG2) genes. Mutational information for patients still on ibrutinib is limited. We repor... | 10.1182/blood.2019000854 | 31,243,043 | D000225:Adenine; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D008297:Male; D008875:Middle Aged; D009154:Mutation; D051966:Phospholipase C g... | Blood | 2,019 | D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; D051966:Phospholipase C gamma; D000225:Adenine |
Miniature drag sphere velocity probe. | The development and testing of a miniature drag sphere velocity probe is described. Impetus for its development arose from a need to investigate the flow structure and turbulence beneath breaking surface water waves, i.e., a requirement for a fast-response small velocity probe which is useable in oscillatory flows. How... | 10.1063/1.1135395 | 18,699,083 | The Review of scientific instruments | 1,978 | ||
Efficacy of transvaginal biofeedback and electrical stimulation in women with urinary urgency and frequency and associated pelvic floor muscle spasm. | Women with urinary urgency and frequency may also have pelvic floor muscle spasm. Transvaginal biofeedback (TVBF) and electrical stimulation (EStim) is a treatment modality that has been used to treat vaginismus and chronic pelvic pain. In this study, TVBF/EStim was evaluated in women with pelvic floor muscle spasm ass... | 19,579,410 | D000328:Adult; D000368:Aged; D001521:Behavior Therapy; D001676:Biofeedback, Psychology; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017773:Pelvic Floor; D010865:Pilot Projects; D012189:Retrospective Studies; D013035:Spasm; D016896:Treatment Outcome; D014555:Urination Diso... | Urologic nursing | 2,009 | ||
Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells. | Because transcription factors NF-kappaB and activator protein-1 (AP-1) are known to regulate gene expression, we have analyzed the role of acetaldehyde in the activation of NF-kappaB and AP-1 in HepG2 cells. Binding activity and transactivation of NF-kappaB and AP-1 were determined by gel retardation assays and transfe... | 10.1074/jbc.275.19.14684 | 10,799,556 | D000079:Acetaldehyde; D001483:Base Sequence; D003600:Cytosol; D004247:DNA; D005786:Gene Expression Regulation; D006801:Humans; D016328:NF-kappa B; D010766:Phosphorylation; D011485:Protein Binding; D011493:Protein Kinase C; D018808:Transcription Factor AP-1; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultu... | The Journal of biological chemistry | 2,000 | D016328:NF-kappa B; D018808:Transcription Factor AP-1; D004247:DNA; D011493:Protein Kinase C; D000079:Acetaldehyde |
Preoperative effects of mifepristone for dilation and evacuation after 19 weeks of gestation: a randomised controlled trial. | OBJECTIVE
To evaluate mifepristone as an adjunct to, or replacement for, osmotic dilators for cervical preparation in surgical abortion after 19 weeks of gestation.
DESIGN
Site-stratified, double-blinded randomised controlled trial.
SETTING
Two tertiary care teaching hospitals.
POPULATION
Women undergoing dilatio... | 10.1111/1471-0528.14900 | 28,834,186 | D000020:Abortifacient Agents, Nonsteroidal; D000028:Abortion, Induced; D000328:Adult; D002584:Cervix Uteri; D003131:Combined Modality Therapy; D004106:Dilatation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015735:Mifepristone; D016595:Misoprostol; D011247:Pregnancy; D011262:Pregnancy Trimester, Secon... | BJOG : an international journal of obstetrics and gynaecology | 2,017 | D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D015735:Mifepristone |
Retrospective Clinical Study of Advanced Pancreatic Cancer Treated With Chemotherapy and Abdominal Hyperthermia. | PURPOSE
Hyperthermia is a mechanistically plausible partner with chemotherapy, although many of the underlying molecular mechanisms of this combination treatment are not yet properly understood. Preclinical studies suggest that there is potential synergy with gemcitabine and that provides the basis for retrospective an... | 10.1200/JGO.2017.009985 | 30,241,198 | D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols; D002945:Cisplatin; D003131:Combined Modality Therapy; D003841:Deoxycytidine; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms;... | Journal of global oncology | 2,018 | D000970:Antineoplastic Agents; D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine |
Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals. | Axonal regeneration plays an important role in functional recovery after nervous system damage. However, after axonal injury in mammals, regeneration is often poor. The deletion of Krüppel-like factor-4 (Klf4) has been shown to promote axonal regeneration in retinal ganglion cells. However, the effects of Klf4 deletion... | 10.4103/1673-5374.286978 | 32,788,472 | Neural regeneration research | 2,021 | ||
Ferrioxamine-mediated Iron(III) utilization by Salmonella enterica. | Utilization of ferrioxamines as sole sources of iron distinguishes Salmonella enterica serotypes Typhimurium and Enteritidis from a number of related species, including Escherichia coli. Ferrioxamine supplements have therefore been used in preenrichment and selection media to increase the bacterial growth rate while se... | 10.1128/AEM.65.4.1610-1618.1999 | 10,103,258 | D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins; D001483:Base Sequence; D001692:Biological Transport; D003676:Deferoxamine; D029968:Escherichia coli Proteins; D005290:Ferric Compounds; D005798:Genes, Bacterial; D007082:Ileum; D007502:Iron Chelating Agents; D051379:Mice; D008969:M... | Applied and environmental microbiology | 1,999 | D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D005290:Ferric Compounds; C489524:FoxA protein, bacteria; C489523:FoxB protein, E coli; D007502:Iron Chelating Agents; D010456:Peptides, Cyclic; D011956:Receptors, Cell Surface; D017262:Siderophores; C072460:foxR protein, bacteria; C017508:fe... |
Widespread copper and lead contamination of household drinking water, New South Wales, Australia. | This study examines arsenic, copper, lead and manganese drinking water contamination at the domestic consumer's kitchen tap in homes of New South Wales, Australia. Analysis of 212 first draw drinking water samples shows that almost 100% and 56% of samples contain detectable concentrations of copper and lead, respective... | 10.1016/j.envres.2016.07.041 | 27,512,893 | D001151:Arsenic; D003300:Copper; D060766:Drinking Water; D006801:Humans; D007854:Lead; D008345:Manganese; D009517:New South Wales | Environmental research | 2,016 | D060766:Drinking Water; D007854:Lead; D008345:Manganese; D003300:Copper; D001151:Arsenic |
Comparison of Different Locking Mechanisms in Total Hip Arthroplasty: Relative Motion between Cup and Inlay. | The resulting inflammatory reaction to polyethylene (PE) wear debris, which may result in osteolysis, is still considered to be a main reason for aseptic loosening. In addition to the primary wear in hip joint replacements caused by head-insert articulation, relative motions between the PE liner and the metal cup may c... | 10.3390/ma13061392 | 32,204,382 | Materials (Basel, Switzerland) | 2,020 | ||
[Asymmetric pulmonary perfusion causing unilateral pulmonary edema as a complication of acute myocardial infarction]. | Acute unilateral pulmonary edema is an unusual clinical condition occasionally associated with severe mitral valve insufficiency. We describe a patient diagnosed as having unilateral pulmonary edema after an acute anterior myocardial infarction. Echocardiograms performed in the acute phase ruled out mitral insufficienc... | 16,022,821 | D000368:Aged; D003937:Diagnosis, Differential; D004417:Dyspnea; D006801:Humans; D008297:Male; D009203:Myocardial Infarction; D011652:Pulmonary Circulation; D011654:Pulmonary Edema; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed | Revista espanola de cardiologia | 2,005 | ||
Rapid separation of immunoglobulin M from immunoglobulin G antibodies for reliable diagnosis of recent rubella infections. | Chromatography on controlled pore glass was adapted for the separation of immunoglobulin M (IgM) and immunoglobulin G (IgG) rubella antibodies from 0.3-ml samples of human serum. An extremely sharp separation of IgM from IgG antibodies could be obtained within 40 min. Nonspecific inhibitors were removed before chromato... | 10.1128/jcm.2.5.377-381.1975 | 1,194,404 | D000914:Antibodies, Viral; D002845:Chromatography; D003937:Diagnosis, Differential; D005898:Glass; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012409:Rubella; D012698:Serologic Tests | Journal of clinical microbiology | 1,975 | D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M |
Assessing the differences in characteristics of patients lost to follow-up at 2 years: results from the Quality Outcomes Database study on outcomes of surgery for grade I spondylolisthesis. | OBJECTIVE
Loss to follow-up has been shown to bias outcomes assessment among studies utilizing clinical registries. Here, the authors analyzed patients enrolled in a national surgical registry and compared the baseline characteristics of patients captured with those lost to follow-up at 2 years.
METHODS
The authors q... | 32,109,871 | Journal of neurosurgery. Spine | 2,020 | |||
Use of whole body sodium loss from the fathead minnow (Pimephales promelas) as an indicator of acid and metal toxicity. | The use of an easily measured physiological change as a method of detecting the effect of toxic mine effluent (acidity, heavy metals) on a standard aquatic test organism was examined. Changes in whole body sodium concentration of Pimephales promelas after exposure for eight hours to mine water in the field were assesse... | 10.1007/BF01055348 | 1,958,081 | D000143:Acids; D000818:Animals; D003530:Cyprinidae; D008670:Metals; D012964:Sodium | Archives of environmental contamination and toxicology | 1,991 | D000143:Acids; D008670:Metals; D012964:Sodium |
An apoplastic peptide activates salicylic acid signalling in maize. | Localized control of cell death is crucial for the resistance of plants to pathogens. Papain-like cysteine proteases (PLCPs) regulate plant defence to drive cell death and protection against biotrophic pathogens. In maize (Zea mays), PLCPs are crucial in the orchestration of salicylic acid (SA)-dependent defence signal... | 10.1038/s41477-018-0116-y | 29,483,684 | D020869:Gene Expression Profiling; D010206:Papain; D010447:Peptide Hydrolases; D010935:Plant Diseases; D010937:Plant Growth Regulators; D057865:Plant Immunity; D010940:Plant Proteins; D020156:Salicylic Acid; D015398:Signal Transduction; D003313:Zea mays | Nature plants | 2,018 | D010937:Plant Growth Regulators; D010940:Plant Proteins; D010447:Peptide Hydrolases; D010206:Papain; D020156:Salicylic Acid |
Endoscopically compatible near-infrared photon migration probe. | We have developed a 2.3-mm-diameter fiber-optic probe for near-infrared photon migration spectroscopy that can be inserted into the body through an endoscope or biopsy needle. This probe is specifically designed to be inserted into a core biopsy needle to facilitate optical sampling of lesions during breast needle biop... | 10.1364/ol.29.002022 | 15,455,767 | D014408:Biomarkers, Tumor; D001707:Biopsy, Needle; D001943:Breast Neoplasms; D019723:Endoscopes; D004724:Endoscopy; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D019047:Phantoms, Imaging; D017785:Photons; D013055:Spectrophotometry, Infrared; D014159:Transducers | Optics letters | 2,004 | D014408:Biomarkers, Tumor |
Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling. | Benzo[a]pyrene (BaP) is a by-product of incomplete combustion of fossil fuels and plant/wood products, including tobacco. A physiologically based pharmacokinetic (PBPK) model for BaP for the rat was extended to simulate inhalation exposures to BaP in rats and humans including particle deposition and dissolution of abso... | 10.1080/08958378.2016.1214768 | 27,569,524 | D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D002273:Carcinogens; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung; D008954:Models, Biological; D052638:Particulate Matter; D051381:Rats | Inhalation toxicology | 2,016 | D001580:Benzopyrenes; D002273:Carcinogens; D052638:Particulate Matter; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene |
Hydrogen peroxide formation by cells treated with a tumor promoter. | To determine whether oxidants capable of DNA modification are produced by cells treated with tumor promoters, we adapted a fluorometric method to our needs. HeLa cells were preincubated with 2',7'-dichlorofluorescin diacetate (DCFdAc), treated with various agents, sonicated, centrifuged and fluorescence of the oxidized... | 10.3109/10715769109145860 | 2,060,851 | D001386:Azides; D002273:Carcinogens; D005434:Flow Cytometry; D005452:Fluoresceins; D005470:Fluorometry; D005978:Glutathione; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide; D007501:Iron; D015394:Molecular Structure; D010084:Oxidation-Reduction; D019810:Sodium Azide; D013010:Sonication; D013755:Tetradecan... | Free radical research communications | 1,991 | D001386:Azides; D002273:Carcinogens; D005452:Fluoresceins; C037631:2',7'-dichlorofluorescein; D019810:Sodium Azide; D006861:Hydrogen Peroxide; D007501:Iron; D005978:Glutathione; D013755:Tetradecanoylphorbol Acetate |
Production of phycobiliprotein and carotenoid by efficient extraction from Thermosynechococcus sp. CL-1 cultivation in swine wastewater. | In this study, the performance of TCL-1 cultivation in swine wastewater was observed under various light intensity, treatment type of swine wastewater, and initial biomass concentration. Furthermore, pigments production (phycobiliprotein and carotenoid), was the main target in this study along with optimum extraction m... | 10.1016/j.biortech.2020.124125 | 32,977,095 | D000818:Animals; D018533:Biomass; D002338:Carotenoids; D000458:Cyanobacteria; D008027:Light; D013552:Swine; D062065:Wastewater | Bioresource technology | 2,021 | D062065:Waste Water; D002338:Carotenoids |
[Antitumor activity of several new pentopyranosyl-chloroethylnitrosoureas]. | Six N-(2-chloroethyl)-N-nitrosoureido derivatives of 4-deoxy-DL-pentopyranose have been synthesized and their antitumor activities were evaluated against melanoma MB16 in mice. The nitrosourea 38 was highly active in comparison with the clinically useful CCNU. | 2,957,032 | D000818:Animals; D000970:Antineoplastic Agents; D004353:Drug Evaluation, Preclinical; D008546:Melanoma, Experimental; D051379:Mice; D008810:Mice, Inbred C57BL; D009607:Nitrosourea Compounds; D013329:Structure-Activity Relationship | Comptes rendus des seances de la Societe de biologie et de ses filiales | 1,987 | D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds | |
Assembled dendritic titanium catalysts for enantioselective hetero-Diels-Alder reaction of aldehydes with Danishefsky's diene. | A new type of dendritic 2-amino-2'-hydroxy-1,1'-binaphthyl (NOBIN)-derived Schiff-base ligands have been synthesized and applied to the titanium-catalyzed hetero-Diels-Alder reaction of Danishefsky's diene with aldehydes. These reactions afforded the corresponding 2-substituted 2,3-dihydro-4H-pyran-4-ones in quantitati... | 10.1002/chem.200305286 | 14,679,511 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,003 | ||
Jejunal Infusion of Glucose Decreases Energy Intake to a Greater Extent than Fructose in Adult Male Rats. | BACKGROUND
Intestinal nutrient infusions result in variable decreases in energy intake and body weight based on nutrient type and specific intestinal infusion site.
OBJECTIVE
The objective was to test whether an intrajejunal fructose infusion (FRU) would lower energy intake and body weight and induce similar increase... | 10.3945/jn.116.231860 | 27,581,579 | D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D002149:Energy Intake; D005632:Fructose; D052216:Glucagon-Like Peptide 1; D005947:Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D007583:Jejunum; D008297:Male; D019894:Peptide YY; D051381:Rats; D017207:Rats, Sprague-Dawley | The Journal of nutrition | 2,016 | D001786:Blood Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D019894:Peptide YY; D005632:Fructose; D052216:Glucagon-Like Peptide 1; D005947:Glucose |
Quantitative decision techniques for the health/public sector policy-maker: an analysis and classification of resources. | Policy problems in the health and public sectors are quickly assuming a new level of complexity. Thus, the health/public sector analyst is being confronted with the task of identifying, formulating, evaluating, and making choices among larger and more complicated sets of decision alternatives. Given the context of such... | 10.1215/03616878-3-3-388 | 103,955 | D001634:Bibliographies as Topic; D003362:Cost-Benefit Analysis; D003657:Decision Making; D006285:Health Planning; D009874:Operations Research; D011640:Public Policy; D012106:Research; D014481:United States | Journal of health politics, policy and law | 1,978 | |
Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats. | Although many studies have shown that amino acid ingestion acutely stimulates protein anabolism, only few studies have investigated whether long-term supplementation promotes changes in body composition. We therefore tested the hypothesis that l-leucine (LEU) and l-phenylalanine (PHE) supplementation might have a posit... | 10.1016/j.lfs.2007.04.015 | 17,512,018 | D000818:Animals; D001823:Body Composition; D001835:Body Weight; D019587:Dietary Supplements; D004734:Energy Metabolism; D005247:Feeding Behavior; D005508:Food Deprivation; D007930:Leucine; D008297:Male; D010649:Phenylalanine; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar | Life sciences | 2,007 | D010649:Phenylalanine; D007930:Leucine |
Tunable electronic properties of a proton-responsive N,N-dimethylaminoazobenzene fullerene (C60) dyad. | A basic N,N-dimethylaminoazobenzene-fullerene (C(60)) dyad molecular skeleton is modelled and synthesized. In spite of the myriad use of azobenzene as a photo- and electrochromic moiety, the idea presented herein is to adopt a conceptually different path by using it as a bridge in a donor-bridge-acceptor single-molecul... | 10.1002/cphc.201000564 | 20,957,715 | Chemphyschem : a European journal of chemical physics and physical chemistry | 2,010 | ||
Effect of different kinds of dietary casein on blood cholesterol and triglycerides in pair fed rats. | After casein intake, serum cholesterol levels are dependent on many experimental conditions in rats. The effect of the method of casein preparation was assessed in Wistar rats pair-fed for 4 wk with three identical diets differing only by the type of casein used. Compared with dietary casein and Na caseinate, ingestion... | 1,591,452 | D000818:Animals; D001786:Blood Glucose; D002364:Caseins; D002784:Cholesterol; D004044:Dietary Proteins; D050356:Lipid Metabolism; D008099:Liver; D008297:Male; D016555:Matched-Pair Analysis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides; D014815:Vitamins | Nutrition (Burbank, Los Angeles County, Calif.) | 1,992 | D001786:Blood Glucose; D002364:Caseins; D004044:Dietary Proteins; D014280:Triglycerides; D014815:Vitamins; D002784:Cholesterol | |
Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa. | Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to the mortality of patients with cystic fibrosis. Chronic infection by Pseudomonas induces sustained immune and inflammatory responses and damage to the airway. The ability of Pseudomonas to resist host defenses is aided, in part, by se... | 10.1074/jbc.M112.369520 | 22,859,302 | D000818:Animals; D001426:Bacterial Proteins; D001980:Bronchi; D002460:Cell Line; D016764:Cell Polarity; D003550:Cystic Fibrosis; D010450:Endopeptidases; D004847:Epithelial Cells; D053503:Epithelial Sodium Channels; D006801:Humans; D051379:Mice; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa | The Journal of biological chemistry | 2,012 | D001426:Bacterial Proteins; D053503:Epithelial Sodium Channels; D010450:Endopeptidases; C087822:alkaline protease |
Use of Transesophageal Echocardiography to Improve the Safety of Transvenous Lead Extraction. | OBJECTIVES
The aim of this study was to evaluate the utility of transesophageal echocardiography (TEE) during transvenous lead extraction (TLE) involving both conventional and laser lead removal.
BACKGROUND
TLE carries a small but measurable risk of serious adverse events. Few studies have examined the potential bene... | 10.1016/j.jacep.2015.07.007 | 29,759,473 | JACC. Clinical electrophysiology | 2,015 | ||
A 3D in vitro model to explore the inter-conversion between epithelial and mesenchymal states during EMT and its reversion. | Epithelial-to-mesenchymal transitions (EMT) are strongly implicated in cancer dissemination. Intermediate states, arising from inter-conversion between epithelial (E) and mesenchymal (M) states, are characterized by phenotypic heterogeneity combining E and M features and increased plasticity. Hybrid EMT states are high... | 10.1038/srep27072 | 27,255,191 | D000199:Actins; D000464:Alginates; D000818:Animals; D015415:Biomarkers; D015820:Cadherins; D018929:Cell Culture Techniques; D002460:Cell Line; D004847:Epithelial Cells; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015870:Gene Expression; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D019394:Ki-67 Ant... | Scientific reports | 2,016 | D000199:Actins; D000464:Alginates; D015415:Biomarkers; D015820:Cadherins; C000611838:Cdh1 protein, mouse; D006603:Hexuronic Acids; D019394:Ki-67 Antigen; C498355:Mki67 protein, mouse; D062793:Occludin; C568986:Ocln protein, mouse; D053773:Transforming Growth Factor beta1; D020723:Glucuronic Acid |
Gene expression in Xenopus laevis embryos after Triadimefon exposure. | The triazole derivative Triadimefon (FON) is a systemic fungicide used to control powdery mildews, rusts, and other fungal pests. Some data have already been published about the teratogenic activity of this compound: craniofacial malformations were found in mouse, rat, and Xenopus laevis embryos exposed to FON. These a... | 10.1016/j.modgep.2006.06.003 | 16,875,885 | D000818:Animals; D002465:Cell Movement; D003577:Cytochrome P-450 Enzyme System; D005659:Fungicides, Industrial; D005775:Gastrula; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins; D017403:In Situ Hybridization; D009432:Neural Crest; D018168:Receptors, Retinoic Acid; D000072516:Retinoic Ac... | Gene expression patterns : GEP | 2,007 | D005659:Fungicides, Industrial; D018398:Homeodomain Proteins; C489830:Hoxa2 protein, Xenopus; C104164:NKX3-2 protein, Xenopus; D018168:Receptors, Retinoic Acid; D013723:Teratogens; D014157:Transcription Factors; D014230:Triazoles; D029867:Xenopus Proteins; C032910:triadimefon; D014212:Tretinoin; D003577:Cytochrome P-45... |
Coassembly of Lysozyme and Amphiphilic Biomolecules Driven by Unimer-Aggregate Equilibrium. | Synthesis and self-assembly of bioconjugates composed of proteins and synthetic molecules have been widely studied because of the potential applications in medicine, biotechnology, and nanotechnology. One of the challenging research studies in this area is to develop organic solvent-free approaches to the synthesis and... | 10.1021/acs.jpcb.8b01447 | 29,558,140 | D000818:Animals; D002645:Chickens; D002784:Cholesterol; D005978:Glutathione; D015394:Molecular Structure; D009113:Muramidase; D066329:Protein Aggregates; D013501:Surface-Active Agents | The journal of physical chemistry. B | 2,018 | D066329:Protein Aggregates; D013501:Surface-Active Agents; D002784:Cholesterol; C421864:hen egg lysozyme; D009113:Muramidase; D005978:Glutathione |
Blood chemistry profile of a South Pacific Island population. | AIMS
To determine basic blood chemistry parameters in the population of the island of Mauke in the South Pacific.
METHODS
As a part of a health survey carried out in 1992, 24 laboratory parameters were measured in serum samples of 502 subjects representing 80.8% of the total population.
RESULTS
Blood glucose, uric ... | 10,914,509 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001774:Blood Chemical Analysis; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases; D003920:Diabetes Mellitus; D005260:Female; D006304:Health Status; D006801:Humans; D000090463:Iron Deficiencies; D007674... | The New Zealand medical journal | 2,000 | D015415:Biomarkers | |
Water-dispersible molecularly imprinted nanohybrids via co-assembly of carbon nanotubes with amphiphilic copolymer and photocrosslinking for highly sensitive and selective paracetamol detection. | A novel kind of water-dispersible molecularly imprinted nanohybrids containing multi-walled carbon nanotubes (MWCNTs) was prepared via the combination of co-assembly and photocrosslinking, and employed to construct an electrochemical sensor. A photo-crosslinkable amphiphilic copolymer (Poly(AA-co-VMc-co-EHA), PDHES) wa... | 10.1016/j.bios.2018.07.009 | 30,014,945 | D000082:Acetaminophen; D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D054802:Molecular Imprinting; D037742:Nanotubes, Carbon; D011108:Polymers; D013501:Surface-Active Agents; D016482:Urinalysis; D014867:Water | Biosensors & bioelectronics | 2,018 | D037742:Nanotubes, Carbon; D011108:Polymers; D013501:Surface-Active Agents; D014867:Water; D000082:Acetaminophen |
A sensitive, precise and rapid LC-MS/MS method for determination of ergosterol peroxide in Paecilomyces cicadae mycelium. | Ergosterol peroxide (EP) has considerable potential effect against the proliferation of tumor cells. Here, we established a new approach for EP content detection through liquid chromatography-tandem mass spectrometry. The specificity, limit of detection (LOD)/quantitative (LOQ), linearity and range, accuracy, repeatabi... | 10.1016/j.steroids.2020.108751 | 33,075,399 | D002853:Chromatography, Liquid; D032661:Cordyceps; D003470:Culture Media; D004875:Ergosterol; D057230:Limit of Detection; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry | Steroids | 2,020 | D003470:Culture Media; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol |
Trunk Muscle Mass Measured by Bioelectrical Impedance Analysis Reflecting the Cross-Sectional Area of the Paravertebral Muscles and Back Muscle Strength: A Cross-Sectional Analysis of a Prospective Cohort Study of Elderly Population. | Trunk muscles play an important role in supporting the spinal column. A decline in trunk muscle mass, as measured by bioelectrical impedance analysis (TMM-BIA), is associated with low back pain and poor quality of life. The purpose of this study was to determine whether TMM-BIA correlates with quantitative and function... | 10.3390/jcm10061187 | 33,809,059 | Journal of clinical medicine | 2,021 | ||
Muscle mechanical properties of strength and endurance athletes and changes after one week of intensive training. | The study investigates whether tensiomyography (TMG) is sensitive to differentiate between strength and endurance athletes, and to monitor fatigue after either one week of intensive strength (ST) or endurance (END) training. Fourteen strength (24.1±2.0years) and eleven endurance athletes (25.5±4.8years) performed an in... | 27,317,976 | D000328:Adult; D056352:Athletes; D004576:Electromyography; D006801:Humans; D008297:Male; D053580:Muscle Strength; D018482:Muscle, Skeletal; D010807:Physical Endurance; D055070:Resistance Training; D013997:Time Factors; D055815:Young Adult | Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology | 2,016 | ||
A heavy heart; A massive right atrial myxoma causing fatigue and shortness of breath. | Cardiac myxomas are rare. The clinical diagnosis of an atrial myxoma may occur in an asymptomatic patient but may also present with cardiac failure, syncope, arrythmias, or with vascular evidence of tumour embolisation. The delay in diagnosis from presentation is approximately ten months. We present the case of a 53-ye... | 20,666,072 | D003952:Diagnostic Imaging; D004417:Dyspnea; D005221:Fatigue; D005260:Female; D006325:Heart Atria; D006338:Heart Neoplasms; D006801:Humans; D008875:Middle Aged; D009232:Myxoma | Irish medical journal | 2,010 | ||
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. | Poly(ADP-ribose) polymerase (PARP) inhibitors are strikingly toxic to cells with defects in homologous recombination (HR). The mechanistic basis for these findings is incompletely understood. Here, we show that PARP inhibitor treatment induces phosphorylation of DNA-dependent protein kinase substrates and stimulates er... | 10.1073/pnas.1013715108 | 21,300,883 | D000818:Animals; D016923:Cell Death; D002460:Cell Line; D004260:DNA Repair; D051747:DNA-Activated Protein Kinase; D004791:Enzyme Inhibitors; D042822:Genomic Instability; D051379:Mice; D010766:Phosphorylation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011995:Recombination, Genetic | Proceedings of the National Academy of Sciences of the United States of America | 2,011 | D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D051747:DNA-Activated Protein Kinase |
Development of STR profiles from firearms and fired cartridge cases. | Fired cartridge cases are a common type of evidence found at crime scenes. However, due to the high chamber temperatures and touch nature of this evidence, DNA testing is not commonly sought because it is believed DNA is only present in low levels, whether it is due to initial low levels of DNA and/or DNA degradation f... | 10.1016/j.fsigen.2009.02.007 | 19,647,709 | D000483:Alleles; D004247:DNA; D016172:DNA Fingerprinting; D005389:Firearms; D005554:Forensic Medicine; D006801:Humans; D018895:Microsatellite Repeats; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction; D011933:Reagent Kits, Diagnostic; D013048:Specimen Handling | Forensic science international. Genetics | 2,009 | D011933:Reagent Kits, Diagnostic; D004247:DNA |
SLPW: A Virulent Bacteriophage Targeting Methicillin-Resistant Staphylococcus aureus In vitro and In vivo. | Staphylococcus aureus (S. aureus) is a Gram-positive pathogen causing a variety of infections in humans and animals. Extensive use of antibiotics has led to the emergence of methicillin-resistant S. aureus (MRSA). As an alternative antibacterial agent against drug-resistant S. aureus, a lytic phage, designated SLPW, wa... | 10.3389/fmicb.2016.00934 | 27,379,064 | Frontiers in microbiology | 2,016 | ||
A Digital Technique to Manage Restoration of Severely Tilted Adjacent Implants: A Dental Technique. | Implant placement in close proximity with adverse angulations may result in difficulty with impression making. With the lock surface function provided by intraoral scanning software programs, severely tilted adjacent implants can be digitized one by one without interfering with the accuracy of the digital cast. This ar... | 10.1111/jopr.13509 | 35,340,075 | D017076:Computer-Aided Design; D015921:Dental Implants; D003760:Dental Impression Materials; D003761:Dental Impression Technique; D003765:Models, Dental | Journal of prosthodontics : official journal of the American College of Prosthodontists | 2,022 | D015921:Dental Implants; D003760:Dental Impression Materials |
Classification analyses for prostate cancer, benign prostate hyperplasia and healthy subjects by SERS-based immunoassay of multiple tumour markers. | Prostate cancer (PCa) is a leading cause of cancer-related death among males globally. To date, prostate-specific antigen (PSA), as a typical tumour marker, has been widely used in the early diagnosis of PCa. However, in practical clinical tests, high serum levels of PSA show a high probability for false-positive resul... | 10.1016/j.talanta.2018.05.070 | 30,029,370 | D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000906:Antibodies; D000954:Antigens, Surface; D001565:Benzoates; D014408:Biomarkers, Tumor; D043425:Glutamate Carboxypeptidase II; D006801:Humans; D007118:Immunoassay; D057230:Limit of Detection; D008297:Male; D053768:Metal Nanoparticles; D008875:Middle Aged... | Talanta | 2,018 | D000906:Antibodies; D000954:Antigens, Surface; D001565:Benzoates; D014408:Biomarkers, Tumor; D013438:Sulfhydryl Compounds; C013594:4-mercaptobenzoate; D012834:Silver; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D020840:Tissue Kallikreins; D017430:Prostate-Specific Antigen |
The dual nature of tools and their makeover. | Vaesen argues that functional knowledge differentiates humans from non-human primates. However, the rationale he provides for this position is open to question--with respect to both the underlying theoretical assumptions and inferences drawn from certain empirical studies. Indeed, there is some recent empirical work th... | 10.1017/S0140525X11002135 | 22,697,805 | D000818:Animals; D003071:Cognition; D006801:Humans; D011597:Psychomotor Performance; D013672:Technology; D053001:Tool Use Behavior | The Behavioral and brain sciences | 2,012 | |
The Low Carb Program for people with type 2 diabetes and pre-diabetes: a mixed methods feasibility study of signposting from general practice. | BACKGROUND
Evidence shows type 2 diabetes mellitus (T2DM) can be effectively treated with a reduced-carbohydrate diet to support weight loss. Digital apps are increasingly used to support weight loss, yet little is known about their use as part of general practice diabetes care.
AIM
Determine the feasibility of signp... | 10.3399/BJGPO.2021.0137 | 34,580,066 | BJGP open | 2,022 | ||
Simultaneous incorporation of mass and force terms in the multi-relaxation-time framework for lattice Boltzmann schemes. | This paper presents an analysis of the simultaneous incorporation of force and mass source terms into the multi-relaxation-time (MRT) collision operator. MRT force incorporation was obtained through Chapman-Enskog analysis. The numerical scheme was tested on different benchmark problems, including the decay of a shear ... | 10.1098/rsta.2011.0018 | 21,536,568 | Philosophical transactions. Series A, Mathematical, physical, and engineering sciences | 2,011 | ||
[Influence of surgical technique on graft and endothelial survival in endothelial keratoplasty]. | PURPOSE
To report survival of the graft and its endothelium after Descemet Stripping Endothelial Keratoplasty (DSEK) in a series of consecutive cases with no exclusion of cases corresponding to the learning curve and to analyze the influence of surgical techniques on survival.
PATIENTS AND METHODS
This prospective ob... | 25,287,818 | D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D057111:Descemet Stripping Endothelial Keratoplasty; D042783:Endothelial Cells; D006085:Graft Survival; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies | Journal francais d'ophtalmologie | 2,014 | ||
Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. | Manganese (Mn) is an essential micronutrient for development and function of the nervous system. Deficiencies in Mn transport have been implicated in the pathogenesis of Huntington's disease (HD), an autosomal dominant neurodegenerative disorder characterized by loss of medium spiny neurons of the striatum. Brain Mn le... | 10.1039/c4mt00223g | 25,599,126 | D000818:Animals; D002460:Cell Line; D006816:Huntington Disease; D008345:Manganese; D055432:Metabolomics; D051379:Mice; D008954:Models, Biological; D009474:Neurons; D025341:Principal Component Analysis | Metallomics : integrated biometal science | 2,015 | D008345:Manganese |
Muscarinic and nicotinic modulation of cortical acetylcholine release monitored by in vivo microdialysis in freely moving adult rats. | The aim of the present study was to investigate, using in vivo dialysis, the existence of muscarinic and nicotinic receptors controlling acetylcholine release in the cortex of freely behaving rats. Various muscarinic receptor antagonists, including the nonselective blocker atropine, and a variety of M2 drugs (AF-DX116,... | 10.1002/syn.890170205 | 8,091,306 | D000109:Acetylcholine; D000818:Animals; D002540:Cerebral Cortex; D004347:Drug Interactions; D005731:Ganglionic Stimulants; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D017551:Microdialysis; D009411:Nerve Endings; D010277:Parasympathomimetics; D011188:Potassium; D051381:Rats; D017207:Rats, Sprague-Dawley... | Synapse (New York, N.Y.) | 1,994 | D005731:Ganglionic Stimulants; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D000109:Acetylcholine; D011188:Potassium |
Exacerbation of inflammatory bowel disease by nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors: fact or fiction? | The existence of a possible link between inflammatory bowel disease (IBD) and nonsteroidal anti-inflammatory drugs (NSAIDs) has been repeatedly suggested. Recently, a few studies have addressed the issue of a possible, similar effect by selective cyclooxygenase-2 inhibitors (COXIBs). The present article reviews the ava... | 10.3748/wjg.v12.i10.1509 | 16,570,341 | D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003092:Colitis; D003106:Colon; D052246:Cyclooxygenase 2 Inhibitors; D006801:Humans; D015212:Inflammatory Bowel Diseases | World journal of gastroenterology | 2,006 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors |
Rickettsia rickettsii infection protects human microvascular endothelial cells against staurosporine-induced apoptosis by a cIAP(2)-independent mechanism. | BACKGROUND
Manipulation of host cell death is an important determinant of the outcome of an infection. Here, we investigate whether Rickettsia rickettsii-infected host endothelial cells resist the effects of staurosporine, a potent inducer of apoptosis, and we explore the mechanisms underlying the anti-apoptotic effect... | 10.1086/597805 | 19,358,671 | D000818:Animals; D017209:Apoptosis; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D016923:Cell Death; D002522:Chlorocebus aethiops; D004730:Endothelium, Vascular; D004791:Enzyme Inhibitors; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008833:Microcirculation; D020411:Oligonucleotide Array Sequenc... | The Journal of infectious diseases | 2,009 | D004791:Enzyme Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C494832:BIRC3 protein, human; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D044767:Ubiquitin-Protein Ligases; D019311:Staurosporine |
Early childhood length-for-age is associated with the work status of Filipino young adults. | Most studies on childhood health and human capital in developing countries examine how early childhood linear growth relates to later human productivity as reflected in schooling success. Work status is another important human capital outcome related to early child health. This study examines the relationship of linear... | 10.1016/j.ehb.2009.01.010 | 19,261,549 | D000328:Adult; D002657:Child Development; D002675:Child, Preschool; D004651:Employment; D005260:Female; D006306:Health Surveys; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010679:Philippines; D055815:Young Adult | Economics and human biology | 2,009 | |
Off-pump coronary artery bypass is a safe option in patients presenting as emergency. | INTRODUCTION
The applicability of off-pump coronary-artery bypass (OPCAB) in patients who present as emergency remains controversial. Herein, we explore the efficacy and safety of OPCAB in patients who were indicated for emergency surgery.
MATERIALS AND METHODS
Between 2002 and 2007, a total of 282 patients underwent... | 20,838,701 | D015331:Cohort Studies; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease; D004638:Emergency Treatment; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012449:... | Annals of the Academy of Medicine, Singapore | 2,010 | ||
Insulin resistance and metabolic hepatocarcinogenesis with parent-of-origin effects in A×B mice. | Insulin resistance is a defining feature of metabolic syndrome and type 2 diabetes mellitus but also may occur independently of these conditions. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of these disorders, increases the risk of hepatocellular carcinoma (HCC). However, mechanisms linking hype... | 10.1016/j.ajpath.2011.08.014 | 21,967,816 | D017667:Adipocytes; D000818:Animals; D006528:Carcinoma, Hepatocellular; D002471:Cell Transformation, Neoplastic; D016207:Cytokines; D004195:Disease Models, Animal; D004843:Epistasis, Genetic; D005234:Fatty Liver; D005260:Female; D018392:Genomic Imprinting; D022781:Hepatocytes; D006946:Hyperinsulinism; D007333:Insulin R... | The American journal of pathology | 2,011 | D016207:Cytokines |
Role of the gap junction in ischemic preconditioning in the heart. | The gap junction plays roles not only in electrical coupling of cardiomyocytes but also in intercellular transport of biologically active substances. Furthermore, the gap junction participates in decision making on cell survival versus cell death in various types of cells, and a part of reperfusion injury in the heart ... | 10.1152/ajpheart.00879.2009 | 20,118,409 | D000818:Animals; D002450:Cell Communication; D002463:Cell Membrane Permeability; D002470:Cell Survival; D017629:Gap Junctions; D019157:Ischemic Preconditioning, Myocardial; D023421:Models, Animal; D032383:Myocytes, Cardiac | American journal of physiology. Heart and circulatory physiology | 2,010 | |
A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia. | The search for new molecules to fight Pseudomonas aeruginosa is of paramount importance. Carbon monoxide (CO) is known to act as an effective inhibitor of the respiratory chain in P. aeruginosa, but the practical use of this gas as an antibacterial molecule is hampered by its toxicity and difficulty to manipulate. Here... | 10.1096/fj.08-122804 | 19,095,732 | D000818:Animals; D000900:Anti-Bacterial Agents; D016470:Bacteremia; D002460:Cell Line; D002470:Cell Survival; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D051379:Mice; D023421:Models, Animal; D009942:Organometallic Compounds; D010101:Oxygen Consumption; D011550:Pseudomonas aeruginosa; D01... | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2,009 | D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C476530:tricarbonylchloro(glycinato)ruthenium(II) |
Immunohistochemical evaluation of estrogen and progesterone receptors of pre and post-neoadjuvant chemotherapy for breast cancer. | OBJECTIVE
To evaluate the immunoexpression of estrogen and progesterone receptors in biopsies and surgical specimens of patients with breast cancer before and after neoadjuvant chemotherapy and to correlate their changes with the pattern of response to chemotherapy and diagnosis of menopause.
METHODS
We selected 47 p... | 22,664,513 | D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone | Revista do Colegio Brasileiro de Cirurgioes | 2,012 | D011960:Receptors, Estrogen; D011980:Receptors, Progesterone | |
Non-adherence to medication: a challenge for person-centred pharmacotherapy to resolve the problem. | Pharmacotherapy today is claimed to be fascinating, scientific, rational, and objective, very much evidence-based, powerful and fundamental form of treatment for many medical conditions. Non-adherence to medication as an invisible epidemic is argued to be an Achilles' heel of evidence based medicine. Person-centered ps... | 25,433,315 | Psychiatria Danubina | 2,014 | |||
Managed and Unmanaged Pinus sylvestris Forest Stands Harbour Similar Diversity and Composition of the Phyllosphere and Soil Fungi. | The aim was to assess fungal communities associated with living needles and soil of Pinus sylvestris in managed and unmanaged forest stands to get a better understanding of whether and how different intensities of forest management affects fungal diversity and community composition under the north temperate forest zone... | 10.3390/microorganisms8020259 | 32,075,257 | Microorganisms | 2,020 | ||
Absorption of paraquat by rat gut in vitro. Regional differences. | The absorption of radioactively labeled paraquat was measured in rat ileum, jejunum and colon by a micro everted sac technique (Semenza and Muhlhaupt, 1969). The absorption rate increased linearly over the range of concentrations measured (10(-5) to 10(-2) M) and was enhanced by nearly 50% in the absence of sodium ions... | 10.1007/BF00333616 | 533,375 | D000818:Animals; D003106:Colon; D004032:Diet; D007082:Ileum; D007408:Intestinal Absorption; D007583:Jejunum; D007700:Kinetics; D008297:Male; D010269:Paraquat; D051381:Rats | Archives of toxicology | 1,979 | D010269:Paraquat |
Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor. | Transcripts of the human IFN alpha-receptor (IFNAR) gene, lacking the transmembrane (TM) domain were found in human myeloma U266S cells, in addition to the transmembranal IFNAR cDNA. Two different cDNAs encoding such soluble IFNAR forms were identified. Form 1 has a deletion causing a frameshift toward the end of the e... | 10.1016/0014-5793(94)80287-4 | 8,307,198 | D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D017384:Sequence ... | FEBS letters | 1,994 | D012333:RNA, Messenger; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta; D004247:DNA |
Anisotropy-based sensing with reference fluorophores. | We describe a new approach to fluorescence sensing based on measurements of steady-state anisotropies in the presence of reference fluorophores with known anisotropies. The basic concept is that the anisotropy of a mixture reflects a weighted average of the anisotropies of the emitting species. By use of reference fluo... | 10.1006/abio.1998.3029 | 10,036,147 | D016880:Anisotropy; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D011485:Protein Binding | Analytical biochemistry | 1,999 | |
Core needle breast biopsy in patients undergoing anticoagulation therapy: preliminary results. | OBJECTIVE
We compared complication rates of core needle breast biopsy in patients with and without concurrent anticoagulation therapy.
SUBJECTS AND METHODS
Experience with 501 14-gauge and 179 11-gauge core needle breast biopsies was recorded prospectively. We performed 18 (3%) of 680 procedures on patients undergoin... | 10.2214/ajr.174.1.1740245 | 10,628,487 | D000925:Anticoagulants; D001707:Biopsy, Needle; D001940:Breast; D005260:Female; D006406:Hematoma; D006470:Hemorrhage; D006801:Humans; D011446:Prospective Studies; D012307:Risk Factors; D018084:Ultrasonography, Interventional | AJR. American journal of roentgenology | 2,000 | D000925:Anticoagulants |
[Latent factors generating health behavior and health consciousness]. | PURPOSE
The purpose of the present study was to explore structural relationships among health behavior and health consciousness and to delineate latent factors underlying them.
METHODS
Data used in this study were obtained from a mail survey conducted by Toshima City Government, Tokyo, in 2002. The subjects were 3,00... | 17,228,753 | D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001294:Attitude to Health; D003243:Consciousness; D005260:Female; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D011634:Public Health; D011795:Surveys and Questionnaires | [Nihon koshu eisei zasshi] Japanese journal of public health | 2,006 | ||
Is extended and saturation biopsy necessary? | Prostate biopsy (PBx) techniques have significantly changed since the original Hodge's 'sextant scheme', which should now be considered obsolete. The feasibility of carrying out a biopsy scheme with a high number of cores in an outpatient setting is a result of the great improvement and efficacy of local anesthesia. Pe... | 10.1111/j.1442-2042.2010.02479.x | 20,415,706 | D001706:Biopsy; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms; D014463:Ultrasonography; D019564:Unnecessary Procedures | International journal of urology : official journal of the Japanese Urological Association | 2,010 | |
An intercostal-phrenic inhibitory reflex in human newborn infants. | An effect of phasic distortion of the rib cage on inspiratory time was studied in thirty sleeping newborn infants. Distortion was produced by both manual compression of various rib cage diameters, and by occluding the airway at functional residual capacity, allowing diaphragmatic contraction to alter rib cage shape. Wi... | 10.1152/jappl.1976.40.3.352 | 931,849 | D000402:Airway Obstruction; D003964:Diaphragm; D004594:Electrophysiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007366:Intercostal Muscles; D010791:Phrenic Nerve; D012123:Pulmonary Ventilation; D012018:Reflex; D013990:Tidal Volume | Journal of applied physiology | 1,976 | |
Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. | High-performance liquid chromatographic assays for the O- and N-demethylated oxidative metabolites of hydrocodone and oxycodone formed in human liver microsomes are described. A solvent-solvent extraction/re-extraction procedure followed by reversed-phase HPLC with UV detection at 210 nm allows for the quantification o... | 10.1016/s1570-0232(02)00856-5 | 12,535,841 | D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006853:Hydrocodone; D008745:Methylation; D008862:Microsomes, Liver; D010098:Oxycodone; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | 2,003 | D006853:Hydrocodone; D010098:Oxycodone |
Prediction of prostate cancer in unscreened men: external validation of a risk calculator. | BACKGROUND
Prediction models need external validation to assess their value beyond the setting where the model was derived from.
OBJECTIVE
To assess the external validity of the European Randomized study of Screening for Prostate Cancer (ERSPC) risk calculator (www.prostatecancer-riskcalculator.com) for the probabili... | 10.1016/j.ejca.2010.11.012 | 21,163,642 | D000368:Aged; D001707:Biopsy, Needle; D055088:Early Detection of Cancer; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms; D018570:Risk Assessment | European journal of cancer (Oxford, England : 1990) | 2,011 | D017430:Prostate-Specific Antigen |
Coupling between visual information and body sway in adults with Down syndrome. | BACKGROUND
Prior studies suggest that infants with Down syndrome (DS) need more experience to acquire a similar relationship between visual information and body sway than infants without DS. However, it is unclear how adults with DS deal with visual information to control posture.
AIM
To examine the coupling between ... | 27,587,352 | D000328:Adult; D016022:Case-Control Studies; D003463:Cues; D004314:Down Syndrome; D005260:Female; D006801:Humans; D008297:Male; D009039:Motion Perception; D009068:Movement; D004856:Postural Balance; D014796:Visual Perception; D055815:Young Adult | Research in developmental disabilities | 2,016 | ||
Penetration of ((14)C)-Efinaconazole Topical Solution, 10%, Does Not Appear to be Influenced by Nail Polish. | Onychomycosis is a common nail disorder with significant medical impacts and aesthetic consequences. Patients seek treatment for several reasons, including the unsightliness of the nail(s). Even with successful management, it takes months for the diseased nail to appear cosmetically normal. Patients commonly apply nail... | 25,276,275 | The Journal of clinical and aesthetic dermatology | 2,014 | |||
Modification of the basic side chain in tamoxifen: effects on microsomal metabolism and in vitro biological activity. | The effect of reducing the basicity of the side chain in tamoxifen (1) on in vitro microsomal metabolism and biological potency has been investigated. The N-methyl-N-(2,2,2-trifluoroethyl) analogue 10 and its 4-hydroxy derivative 18 have been synthesised. The side chain of 10 was not metabolised detectably by rat liver... | 3,450,297 | D000818:Animals; D002455:Cell Division; D008297:Male; D008862:Microsomes, Liver; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen; D013329:Structure-Activity Relationship; D013629:Tamoxifen; D014407:Tumor Cells, Cultured | Anti-cancer drug design | 1,986 | D011960:Receptors, Estrogen; D013629:Tamoxifen | |
Epidemiology, species distribution, antifungal susceptibility, and ERG11 mutations of Candida species isolated from pregnant Chinese Han women. | The widespread use of antifungal agents has led to increasing azole resistance in Candida species. A major azole-resistance mechanism involves point mutations in the ERG11 gene, which encodes cytochrome P450 lanosterol 14a-demethylase. In this study, vaginal swabs were obtained from 657 pregnant Chinese Han women and c... | 10.4238/gmr.15027168 | 27,173,274 | D000328:Adult; D000935:Antifungal Agents; D002175:Candida; D002177:Candidiasis; D003577:Cytochrome P-450 Enzyme System; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole; D005800:Genes, Fungal; D006801:Humans; D017964:Itraconazole; D020125:Mutation, Missense; D016366:Open Reading Frames; D011247:Preg... | Genetics and molecular research : GMR | 2,016 | D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole; D003577:Cytochrome P-450 Enzyme System |
Isolation of a galactose-free 20-kDa fragment exhibiting butyrylcholine esterase and aryl acylamidase activity from human serum butyrylcholine esterase by limited alpha-chymotrypsin digestion. | Purified human serum butyrylcholine esterase (approximately 90-kDa subunit), which also exhibits aryl acylamidase activity, was subjected to limited alpha-chymotrypsin digestion. Three major protein fragments of approximately 50 kDa, approximately 21 kDa and approximately 20 kDa were found to be produced, as observed b... | 10.1111/j.1432-1033.1989.tb14595.x | 2,646,120 | D000581:Amidohydrolases; D000595:Amino Acid Sequence; D001798:Blood Proteins; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D002918:Chymotrypsin; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases; D005690:Galactose; D006358:Hot T... | European journal of biochemistry | 1,989 | D001798:Blood Proteins; D012685:Sepharose; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D010450:Endopeptidases; D002918:Chymotrypsin; D000581:Amidohydrolases; C019732:aryl acylamidase; D008358:Mannose; D005690:Galactose |
Hormone replacement therapy with L-thyroxine promotes working memory and concentration in thyroidectomized female patients after differentiated thyroid carcinoma. | Objective
It is well established that long-term hypothyroidism is associated with cognitive deficits. Based on recent literature, we hypothesized that pharmacologically induced euthyroidism would lead to improved cognitive performance compared to a hypothyroid state.
Methods
We analyzed data from 14 nondepressed thyr... | 10.1177/0091217419885751 | 31,690,154 | D000328:Adult; D000368:Aged; D001288:Attention; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D013964:Thyroid Neoplasms; D013965:Thyroidectomy; D013974:Thyroxine; D055815:Young Adult | International journal of psychiatry in medicine | 2,020 | D013974:Thyroxine |
A Urine Metabonomics Study of Rat Bladder Cancer by Combining Gas Chromatography-Mass Spectrometry with Random Forest Algorithm. | A urine metabolomics study based on gas chromatography-mass spectrometry (GC-MS) and multivariate statistical analysis was applied to distinguish rat bladder cancer. Urine samples with different stages were collected from animal models, i.e., the early stage, medium stage, and advanced stage of the bladder cancer model... | 10.1155/2020/8839215 | 33,014,064 | International journal of analytical chemistry | 2,020 | ||
[Diurnal changes in the 3-hydroxybutyrate dehydrogenase activity of rat liver mitochondria during chronic alcohol consumption and after cessation]. | The activity of 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) in the isolated rat liver mitochondria changes but slightly during 24 h. In animals which were fed 10% ethanol solution for 3.5 months the enzyme activity varies within the daily cycle: maximum--at 10 p. m., minimum--at 1-4 p. m. and at 4-7 a. m.; the averag... | 3,433,380 | D000437:Alcoholism; D000818:Animals; D002940:Circadian Rhythm; D000431:Ethanol; D006884:Hydroxybutyrate Dehydrogenase; D008297:Male; D008930:Mitochondria, Liver; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome | Ukrainskii biokhimicheskii zhurnal (1978) | 1,987 | D000431:Ethanol; D006884:Hydroxybutyrate Dehydrogenase | |
Determinants of the Intention to Use Smart Healthcare Devices: A Framework and Public Policy Implications. | Healthcare industry is strongly influenced by new digital technologies. In this context, this study creates a framework and explores determinants of the intention to use smart healthcare devices. Several factors were identified, including usefulness, convenience, novelty, price, technological complexity, and perceived ... | 10.1155/2021/4345604 | 34,777,734 | D003695:Delivery of Health Care; D006268:Health Facilities; D006801:Humans; D033182:Intention; D018907:Privacy; D011640:Public Policy | Journal of healthcare engineering | 2,021 | |
Wireless Bladder Pressure Monitor for Closed-Loop Bladder Neuromodulation. | Conditional neuromodulation is a form of closed-loop bladder control where neurostimulation is applied in reaction to bladder pressure changes. Current methods based on external catheters have limited utility for chronic ambulatory therapy. We have developed a wireless pressure monitor to provide real-time, catheter-fr... | 10.1109/ICSENS.2016.7808967 | 34,012,497 | Proceedings of IEEE Sensors. IEEE International Conference on Sensors | 2,016 | ||
Mechanisms mediating the positive inotropic and chronotropic changes induced by dopexamine in the anesthetized dog. | Mechanisms contributing to the increments in heart rate (HR) and cardiac contractile force (CCF) produced by dopexamine (DPX) were studied in anesthetized dogs. Intravenous infusions of DPX (4.0 micrograms/kg/min) produced increments in HR, CCF and renal blood flow and decrements in mean arterial pressure (MAP). The se... | 2,888,876 | D000322:Adrenergic Agonists; D000420:Albuterol; D000758:Anesthesia; D000818:Animals; D001285:Atropine; D001794:Blood Pressure; D004285:Dogs; D004298:Dopamine; D006339:Heart Rate; D018738:Hexamethonium; D006584:Hexamethonium Compounds; D008297:Male; D009200:Myocardial Contraction; D009638:Norepinephrine; D011943:Recepto... | The Journal of pharmacology and experimental therapeutics | 1,987 | D000322:Adrenergic Agonists; D006584:Hexamethonium Compounds; D011943:Receptors, Adrenergic, beta; C046318:dopexamine; D018738:Hexamethonium; D001285:Atropine; D000420:Albuterol; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine | |
Technique, indications, and clinical use of ambulatory 24-hour gastric pH monitoring in a surgical practice. | BACKGROUND
Prolonged pH monitoring is used increasingly to assess alterations of gastric luminal pH caused by gastroduodenal secretory and motor abnormalities. The clinical value of gastric pH monitoring, however, has been debated.
METHODS
We obtained normal values for 24-hour ambulatory gastric pH monitoring in 50 h... | 7,940,176 | D000293:Adolescent; D000328:Adult; D000368:Aged; D004383:Duodenogastric Reflux; D005260:Female; D005744:Gastric Acid; D005745:Gastric Acidity Determination; D005746:Gastric Emptying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013997:Time Fact... | Surgery | 1,994 | ||
Turbidity-corrected Raman spectroscopy for blood analyte detection. | A major challenge in quantitative biological Raman spectroscopy, particularly as applied to transcutaneous Raman spectroscopy measurements, is overcoming the deleterious effects of scattering and absorption (turbidity). The Raman spectral information is distorted by multiple scattering and absorption events in the surr... | 10.1021/ac8025509 | 19,413,337 | D001774:Blood Chemical Analysis; D002138:Calibration; D004867:Equipment Design; D005947:Glucose; D008954:Models, Biological; D015203:Reproducibility of Results; D013059:Spectrum Analysis, Raman | Analytical chemistry | 2,009 | D005947:Glucose |
The nuclear-encoded PsbW protein subunit of photosystem II undergoes light-induced proteolysis. | The repair of photoinhibitory damage to photosystem II involves the rapid degradation and turnover of the D1 reaction center subunit. Additional protein subunits which show a limited degradation at high light intensities are the complementary reaction center subunit, D2, and the two chlorophyll a binding proteins, CP 4... | 10.1021/bi970685o | 9,335,523 | D002467:Cell Nucleus; D002734:Chlorophyll; D000077194:Chlorophyll A; D007700:Kinetics; D008027:Light; D045342:Light-Harvesting Protein Complexes; D046911:Macromolecular Substances; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010782:Photolysis; D045322:Photosynthetic Reaction Center Complex Proteins; D045332:P... | Biochemistry | 1,997 | D045342:Light-Harvesting Protein Complexes; D046911:Macromolecular Substances; D008565:Membrane Proteins; D009687:Nuclear Proteins; D045322:Photosynthetic Reaction Center Complex Proteins; D045332:Photosystem II Protein Complex; D010940:Plant Proteins; C083100:photosystem II, chlorophyll binding protein, CP-43; C070970... |
[Observations during captive bolt stunning of rabbits]. | 78 rabbits of mixed breed and about 3 kg live weight were stunned before slaughter with a commercial spring operated captive bolt apparatus designed for rabbits and water fowl. The following reaction patterns were observed: 1.) Immediate onset of tonic spasm, followed by weak to heavy clonic spasms and/or subsequent re... | 1,543,476 | D000003:Abattoirs; D000827:Animal Welfare; D000818:Animals; D005260:Female; D008297:Male; D011817:Rabbits | Berliner und Munchener tierarztliche Wochenschrift | 1,992 | ||
Strain differences in the inhibition by hemicholinium-3 of the pressor response to intraventricular injection of neostigmine in rats. | The pressor response to intracerebroventricular (i.c.v.) injections of neostigmine was examined in three groups of Sprague-Dawley rats (MFS, CS and CFE) obtained from different breeders and in Long-Evans rats (MLE) obtained from one of the same breeders. All rats responded with a rise in blood pressure to i.c.v. inject... | 10.1111/j.1476-5381.1974.tb09660.x | 4,451,746 | D000818:Animals; D001794:Blood Pressure; D002552:Cerebral Ventricles; D006426:Hemicholinium 3; D007267:Injections; D008297:Male; D009388:Neostigmine; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity | British journal of pharmacology | 1,974 | D006426:Hemicholinium 3; D009388:Neostigmine |
The appropriateness of use of percutaneous transluminal coronary angioplasty in Spain. | BACKGROUND
The rapid increase in the number of percutaneous transluminal coronary angioplasty (PTCA) procedures performed in Spain in recent years raises questions about how appropriately this procedure is being used. To examine this issue, we studied the appropriateness of use of PTCA in Spanish patients and factors a... | 10.1016/s0167-5273(01)00385-0 | 11,376,822 | D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease; D005260:Female; D006801:Humans; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D018579:Patient Selection; D012720:Severity of Illness Index; D013030:Spain | International journal of cardiology | 2,001 | |
Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na. | Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major caus... | 10.1016/s0264-410x(00)00064-5 | 10,781,850 | D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D001426:Bacterial Proteins; D016207:Cytokines; D004797:Enzyme-Linked Immunosorbent Assay; D018604:Epitope Mapping; D015707:HN Protein; D006801:Humans; D051379:Mice; D011994:Recombinant Proteins; D012136:Respiratory Syncytial Viruses; D014759:Viral Env... | Vaccine | 2,000 | D000914:Antibodies, Viral; D000956:Antigens, Viral; D001426:Bacterial Proteins; D016207:Cytokines; D015707:HN Protein; C034284:IgG Fc-binding protein, Streptococcus; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C116204:atta... |
Prevalence and severity of college student bereavement examined in a randomly selected sample. | The authors used stratified random sampling to assess the prevalence and severity of bereavement in college undergraduates, providing an advance over findings that emerge from convenience sampling methods or from anecdotal observations. Prior research using convenience sampling indicated that 22% to 30% of college stud... | 10.1080/07481180903251810 | 24,479,187 | D000223:Adaptation, Psychological; D000328:Adult; D001293:Attitude to Death; D001601:Bereavement; D003863:Depression; D005260:Female; D006801:Humans; D008297:Male; D009769:Object Attachment; D015995:Prevalence; D012720:Severity of Illness Index; D013315:Stress, Psychological; D013334:Students; D055815:Young Adult | Death studies | 2,010 | |
2003: a centennial of spinthariscope and scintillation counting. | In 1903 W. Crookes demonstrated in England his "spinthariscope" for the visual observation of individual scintillations caused by alpha particles impinging upon a ZnS screen. In contrast to the analogue methods of radiation measurements in that time the spinthariscope was a single-particle counter, being the precursor ... | 10.1016/j.apradiso.2004.03.056 | 15,177,355 | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | 2,004 | ||
Factors affecting children's adherence to regular dental attendance: a systematic review. | BACKGROUND
Parents' adherence to regular dental attendance for their young children plays an important role in improving and maintaining children's oral health. The authors conducted a systematic review to determine the factors that influence parental adherence to regular dental attendance for their children.
TYPE OF... | 10.14219/jada.2014.49 | 25,082,930 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003777:Dental Prophylaxis; D006801:Humans; D010290:Parents; D010349:Patient Compliance | Journal of the American Dental Association (1939) | 2,014 | |
Angiogenin-mediated rRNA transcription in cancer and neurodegeneration. | Angiogenin (ANG) is a 14 kDa angiogenic ribonuclease that is upregulated in a variety of human cancers. Accumulating evidence indicates that the angiogenic activity of ANG is related to its ability in regulating ribosomal RNA (rRNA) transcription. ANG is translocated to the nucleus of growth-stimulated endothelial cell... | 20,827,423 | International journal of biochemistry and molecular biology | 2,010 | |||
Slowly but Surely: Adverbs Support Verb Learning in 2-Year-Olds. | To acquire the meanings of verbs, toddlers make use of the surrounding linguistic information. For example, two-year-olds successfully acquire novel transitive verbs that appear in semantically rich frames containing content nouns ("The boy is gonna pilk a balloon"). But, they have difficulty with pronominal frames ("H... | 10.1080/15475441.2013.840493 | 25,143,762 | Language learning and development : the official journal of the Society for Language Development | 2,014 | ||
FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle. | The plasma membrane fatty acid transport protein FAT/CD36 is also present at the mitochondria, where it may contribute to the regulation of fatty acid oxidation, although this has been challenged. Therefore, we have compared enzyme activities and rates of mitochondrial palmitate oxidation in muscles of wild-type (WT) a... | 10.1152/ajpregu.91021.2008 | 19,625,692 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D000818:Animals; D001692:Biological Transport; D018955:CD36 Antigens; D002334:Carnitine O-Palmitoyltransferase; D002950:Citrate (si)-Synthase; D005260:Female; D051379:Mice; D018345:Mice, Knockout; D008931:Mitochondria, Muscle; D009119:Muscle Contraction; D018482:Muscle, Skeleta... | American journal of physiology. Regulatory, integrative and comparative physiology | 2,009 | D018955:CD36 Antigens; D009829:Oleic Acids; D013388:Succinimides; C120556:sulfo-N-succinimidyl oleate; D019308:Palmitic Acid; D019802:Succinic Acid; D015094:3-Hydroxyacyl CoA Dehydrogenases; D002334:Carnitine O-Palmitoyltransferase; D002950:Citrate (si)-Synthase |
[Generalist palliative care for non-cancer patients: A review article]. | BACKGROUND
Most patients in the last phase of life can be treated in the context of generalist palliative care, especially by general practitioners. In contrast to specialized palliative care, non-cancer patients predominate in this setting.
OBJECTIVE
The aim of this article is to review the literature and elaborate ... | 10.1007/s00482-015-0054-9 | 26,351,129 | D000368:Aged; D000369:Aged, 80 and over; D059350:Chronic Pain; D058006:General Practice; D006801:Humans; D033183:Interdisciplinary Communication; D000070516:Intersectoral Collaboration; D010147:Pain Measurement; D010166:Palliative Care; D013727:Terminal Care | Schmerz (Berlin, Germany) | 2,015 | |
Current Role of Uterine Artery Embolization in the Management of Uterine Fibroids. | Uterine artery embolization (UAE) is a well-established therapy for uterine fibroids, with safety and efficacy demonstrated in several comparative randomized trials. It is a minimally invasive procedure, which allows for rapid recovery and return to normal activities. Most studies demonstrate outcomes similar to those ... | 10.1097/GRF.0000000000000162 | 26,630,074 | D000772:Anesthesia, Local; D016292:Conscious Sedation; D019468:Disease Management; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female; D007889:Leiomyoma; D018579:Patient Selection; D011247:Pregnancy; D018873:Pregnancy Rate; D055357:Uterine Artery Embolization; D014594:Uterine Neoplasms | Clinical obstetrics and gynecology | 2,016 | |
Povidone-iodine 3-minute exposure time is viable in preparation for cataract surgery. | PURPOSE
Povidone-iodine (PI) is widely used to reduce the preoperative conjunctival bacterial load. This study aimed to evaluate the employment of PI 10% in an attempt to sterilize the ocular surface prior to cataract surgery, and to show that PI could be left in contact for 3 minutes. The viability of this exposure ti... | 10.5301/ejo.5000964 | 28,430,323 | D000368:Aged; D000891:Anti-Infective Agents, Local; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D018918:Phacoemulsification; D011206:Povidone-Iodine; D011300:Preoperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection; D013997:Time Factors | European journal of ophthalmology | 2,017 | D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions; D011206:Povidone-Iodine |
Regulation of microtubule motors by tubulin isotypes and post-translational modifications. | The 'tubulin-code' hypothesis proposes that different tubulin genes or post-translational modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result in unique interactions with microtubule-associated proteins for specific cellular functions. However, the inability to isolate distinct... | 10.1038/ncb2920 | 24,633,327 | D000595:Amino Acid Sequence; D000818:Animals; D006224:Cricetinae; D004398:Dyneins; D018698:Glutamic Acid; D006801:Humans; D016547:Kinesins; D008868:Microtubule Proteins; D008969:Molecular Sequence Data; D020033:Protein Isoforms; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D014404:Tubulin... | Nature cell biology | 2,014 | D008868:Microtubule Proteins; D020033:Protein Isoforms; D014404:Tubulin; D018698:Glutamic Acid; D014443:Tyrosine; D004398:Dyneins; D016547:Kinesins |
Development and validation of an environmental fragility index (EFI) for the neotropical savannah biome. | Augmented production and transport of fine sediments resulting from increased human activities are major threats to freshwater ecosystems, including reservoirs and their ecosystem services. To support large scale assessment of the likelihood of soil erosion and reservoir sedimentation, we developed and validated an env... | 10.1016/j.scitotenv.2018.04.216 | 29,710,580 | The Science of the total environment | 2,018 | ||
Proteolytic inactivation of alpha 1-antitrypsin and alpha 1-antichymotrypsin by neutrophils in arthritic joints. | OBJECTIVE
In vitro, activated neutrophils create a microenvironment in which proteinase inhibitors are inactivated through the coordinate action of reactive oxygen species and released elastase. We investigated whether such a mechanism may contribute to the destruction of the joint tissues in arthritis.
METHODS
We an... | 10.1002/art.1780360206 | 8,431,205 | D001172:Arthritis, Rheumatoid; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D006801:Humans; D009504:Neutrophils; D012967:Sodium Dodecyl Sulfate; D013582:Synovial Fluid; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin | Arthritis and rheumatism | 1,993 | D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D012967:Sodium Dodecyl Sulfate |
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