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Inhibition of Proteolytic Enzymes from Pseudomonas fluorescens ATCC 948 and Angiotensin I-Converting Enzyme by Peptides from Zein, Hordein, and Gluten Hydrolysates. | Peptides inhibitory to partially purified endopeptidase and crude proteinase from Pseudomonas fluorescens ATCC 948 were isolated from tryptic hydrolysates of zein and hordein by reversed-phase fast protein liquid chromatography and identified by sequencing. The sequences are Ser-Ala-Tyr-Pro-Gly-Gln-Ile-Thr-Ser-Asn and ... | 10.4315/0362-028X-60.5.499 | 31,195,588 | Journal of food protection | 1,997 | ||
Analysis of scientific productivity using maximum entropy principle and fluctuation-dissipation theorem. | Using data retrieved from the INSPEC database we have quantitatively discussed a few syndromes of the publish-or-perish phenomenon, including the continuous growth of the rate of scientific productivity, and the continuously decreasing percentage of those scientists who stay in science for a long time. Making use of th... | 10.1103/PhysRevE.75.026103 | 17,358,390 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,007 | ||
Oral contraceptives may alter the detection of emotions in facial expressions. | A possible effect of oral contraceptives on emotion recognition was observed in the context of a clinical trial with a corticosteroid. Users of oral contraceptives detected significantly fewer facial expressions of sadness, anger and disgust than non-users. This was true for trial participants overall as well as for th... | 25,224,104 | D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents; D003276:Contraceptives, Oral; D004644:Emotions; D005149:Facial Expression; D005260:Female; D005438:Fludrocortisone; D006801:Humans; D021641:Recognition, Psychology | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 2,014 | D000893:Anti-Inflammatory Agents; D003276:Contraceptives, Oral; D005438:Fludrocortisone | |
Natural history of chronic HBV infection: special emphasis on the prognostic implications of the inactive carrier state versus chronic hepatitis. | The evaluation of the natural history of chronic hepatitis B virus (HBV) infection requires the precise definition of the various clinical conditions that can be encountered (i.e. inactive carrier state or subject with liver disease activity). This can be achieved by repeat monitoring of ALT, serum HBV-DNA levels (over... | 10.1016/S1590-8658(10)60686-X | 21,195,374 | D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D006528:Carcinoma, Hepatocellular; D002353:Carrier State; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D008113:Liver Neoplasms; D011379:Prognosis | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver | 2,011 | D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase |
Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. | The cell surface hyaluronan receptor CD44 promotes tumor growth and metastasis by mechanisms that remain poorly understood. We show here that CD44 associates with a proteolytic form of the matrix metalloproteinase-9 (MMP-9) on the surface of mouse mammary carcinoma and human melanoma cells. CD44-associated cell surface... | 10.1101/gad.13.1.35 | 9,887,098 | D000818:Animals; D003094:Collagen; D017364:Collagenases; D004705:Endocytosis; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D007150:Immunohistochemistry; D008325:Mammary Neoplasms, Experimental; D02... | Genes & development | 1,999 | D018960:Hyaluronan Receptors; D012333:RNA, Messenger; D006820:Hyaluronic Acid; D003094:Collagen; D017364:Collagenases; D020780:Matrix Metalloproteinase 9 |
An alternative technique for transfer of anomalous left coronary artery from the pulmonary trunk in children and adults using autogenous aortic and pulmonary arterial flaps. | BACKGROUND
Direct re-implantation of an anomalous left coronary artery into the aorta is the preferred surgical option for creating a dual coronary arterial system in patients in whom the anomalous artery originated from the pulmonary trunk. This technique, however, is applicable only when the anomalous artery arises f... | 10.1017/S1047951107001898 | 18,272,018 | D000328:Adult; D001013:Aorta, Thoracic; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures; D003330:Coronary Vessel Anomalies; D006801:Humans; D007223:Infant; D018579:Patient Selection; D011651:Pulmonary Artery; D013524:Surgical Flaps; D016896:Treatment Outcome | Cardiology in the young | 2,008 | |
Incidence and prevalence of drug-treated attention deficit disorder among boys in the UK. | BACKGROUND
Drug treatment for attention deficit disorder (ADD) was rare in the United Kingdom (UK) until in the mid-1990s. This contrasts with North America, where such treatment has been used to treat ADD for many decades. Since no quantitative data on the incidence and prevalence of drug-treated ADD are available in ... | 15,113,516 | D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity; D000697:Central Nervous System Stimulants; D002648:Child; D002675:Child, Preschool; D003913:Dextroamphetamine; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008774:Methylphenidate; D015995:Prevalence; D006113:Unite... | The British journal of general practice : the journal of the Royal College of General Practitioners | 2,004 | D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003913:Dextroamphetamine | |
Carbonyl iron therapy for iron deficiency anemia. | To determine if elemental carbonyl iron powder is safe and effective therapy for iron deficiency anemia, 20 nonanemic and 32 anemic volunteers were studied. Single doses of 1,000 to 10,000 mg of carbonyl iron (15 to 150 times the 65 mg of iron in the usual dose of ferrous sulfate) were tolerated by nonanemic volunteers... | 3,947,745 | D000328:Adult; D000747:Anemia, Hypochromic; D003365:Costs and Cost Analysis; D004064:Digestive System; D004920:Erythropoiesis; D005293:Ferritins; D006454:Hemoglobins; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron; D054354:Iron Carbonyl Compounds; D009942:Organometallic Compounds | Blood | 1,986 | D006454:Hemoglobins; D009942:Organometallic Compounds; D054354:Iron Carbonyl Compounds; D005293:Ferritins; D007501:Iron | |
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma. | Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20 Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in... | 10.1016/0304-3835(83)90087-3 | 6,640,516 | D000818:Animals; D002460:Cell Line; D008297:Male; D051379:Mice; D009270:Naloxone; D009271:Naltrexone; D009368:Neoplasm Transplantation; D009447:Neuroblastoma; D011336:Probability; D013997:Time Factors | Cancer letters | 1,983 | D009270:Naloxone; D009271:Naltrexone |
Dyslipidemia and lipid peroxidation of Saudi type 2 diabetics with proliferative retinopathy. | OBJECTIVES
To assess lipid profile and lipid peroxidation in type 2 diabetics with proliferative retinopathy (PDR), and investigate the association between these biochemical parameters and PDR.
METHODS
This study was conducted between June 2011 and February 2012 in the Research Laboratory, College of Applied Medical ... | 23,756,927 | D000368:Aged; D001786:Blood Glucose; D002784:Cholesterol; D003924:Diabetes Mellitus, Type 2; D003930:Diabetic Retinopathy; D050171:Dyslipidemias; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged | Saudi medical journal | 2,013 | D001786:Blood Glucose; D006442:Glycated Hemoglobin A; C517652:hemoglobin A1c protein, human; D002784:Cholesterol | |
Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer. | BACKGROUND
Lymphatic and venous involvement is a critical factor in the curability assessment of endoscopically resected gastric cancers; however, the risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers remain unknown.
METHODS
To identify risk factors for lymphatic and venous ... | 10.1007/s00535-012-0696-7 | 23,090,003 | D000230:Adenocarcinoma; D000368:Aged; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms; D019043:Vascular Neoplasms; D014680:Veins | Journal of gastroenterology | 2,013 | |
Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis. | Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of cardiac function and a better marker of proarrhythmia than repolarization prolongation alone. The ionic mechanisms underlying baseline BVR in physiological conditions, its rate dependence, and the factors contributing to increas... | 10.1371/journal.pcbi.1003202 | 23,990,775 | D000200:Action Potentials; D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D004285:Dogs; D006329:Heart Conduction System; D006339:Heart Rate; D006352:Heart Ventricles; D007473:Ion Channels; D016014:Linear Models; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac | PLoS computational biology | 2,013 | D007473:Ion Channels |
The ratio of 3-hydroxyacyl-CoA dehydrogenase to lipoamide dehydrogenase activity in individual muscle fibers: mitochondrial specialization for source of energy. | 3-Hydroxyacyl-CoA dehydrogenase (HAD) has been widely used to assess the capacity for fatty acid oxidation by different muscle fiber types, with various Krebs cycle enzymes as a base for comparison. We have measured this enzyme in individual lyophilized fibers of the guinea pig soleus and the white and red portions of ... | 10.1002/jnr.490080103 | 6,897,429 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase; D004734:Energy Metabolism; D006168:Guinea Pigs; D007700:Kinetics; D008297:Male; D008931:Mitochondria, Muscle | Journal of neuroscience research | 1,982 | D015094:3-Hydroxyacyl CoA Dehydrogenases; D008058:Dihydrolipoamide Dehydrogenase |
Transgenerational effects of maternal bisphenol: a exposure on offspring metabolic health. | Exposure to the endocrine disruptor bisphenol A (BPA) is ubiquitous and associated with health abnormalities that persist in subsequent generations. However, transgenerational effects of BPA on metabolic health are not widely studied. In a maternal C57BL/6J mice (F0) exposure model using BPA doses that are relevant to ... | 10.1017/S2040174418000764 | 30,362,448 | D000393:Air Pollutants; D000818:Animals; D001559:Benzhydryl Compounds; D001835:Body Weight; D004195:Disease Models, Animal; D052244:Endocrine Disruptors; D005260:Female; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D007515:Islets of Langerhans; D008297:Male; D018811:Mate... | Journal of developmental origins of health and disease | 2,019 | D000393:Air Pollutants; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D007328:Insulin; D010636:Phenols; C006780:bisphenol A |
Pregnancy and Parenthood Remain Challenging During Surgical Residency: A Systematic Review. | PURPOSE
To examine common themes and synthesize data surrounding pregnancy and parenthood during surgical residency training.
METHOD
The authors conducted a systematic search of the literature in March 2019. They searched MEDLINE, EMBASE, and Scopus, seeking articles published from 2003 to 2018 that focused on pregna... | 10.1097/ACM.0000000000003351 | 32,271,231 | D000328:Adult; D005260:Female; D006801:Humans; D007396:Internship and Residency; D016487:Parenting; D010822:Physicians, Women; D011247:Pregnancy; D043762:Reproductive Behavior; D057545:Social Stigma; D013337:Students, Medical; D066231:Surgeons; D017132:Workplace | Academic medicine : journal of the Association of American Medical Colleges | 2,020 | |
Comparative Meta-analysis Effects of Nonnative Ants (Hymenoptera: Formicidae), Ground Beetles (Coleoptera: Carabidae), and Bark and Ambrosia Beetles (Coleoptera: Curculionidae) on Native Confamilials. | Nonnative species often transform local communities to the detriment of native species. Much of the existing invasion ecology research focuses on the effects of a few extremely impactful species, and it is less clear how nonnative species which are not causing economic or ecological impacts alter closely related native... | 10.1093/ee/nvab017 | 33,822,028 | D031164:Ambrosia; D000818:Animals; D001000:Ants; D044822:Biodiversity; D001517:Coleoptera; D024301:Plant Bark; D048889:Weevils | Environmental entomology | 2,021 | |
Computational screening for new neuroprotective ingredients against Alzheimer's disease from bilberry by cheminformatics approaches. | Bioactive ingredients from natural products have always been an important resource for the discovery of drugs for Alzheimer's disease (AD). Senile plaques, which are formed with amyloid-beta (Aβ) peptides and excess metal ions, are found in AD brains and have been suggested to play an important role in AD pathogenesis.... | 10.3389/fnut.2022.1061552 | 36,570,129 | Frontiers in nutrition | 2,022 | ||
Concentration changes of PCDDs, PCDFs, and dioxin-like PCBs in human breast milk samples as shown by a follow-up survey. | Breast milk is known to discharge dioxins from the human body. However, to date, no direct comparison has been made of the concentrations of dioxin analogues in breast milk obtained from identical population after successive deliveries. We present here follow-up survey results of PCDDs, PCDFs, and dioxin-like PCBs conc... | 10.1016/j.chemosphere.2005.10.054 | 16,375,948 | D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008895:Milk, Human; D011078:Polychlorinated Biphenyls; D000072317:Polychlorinated Dibenzodioxins | Chemosphere | 2,006 | D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls |
Fibula nail fixation in ankle fractures with significant soft tissue compromise: a retrospective cohort study. | PURPOSE
Intramedullary fixation of lateral malleolar fractures has increased in popularity recently with the introduction of the fibula nail. It has been proposed as an alternative fixation method in fractures to minimise soft tissue injury. The aim of this study was to evaluate the clinical and patient-reported outcom... | 10.1007/s00590-021-03088-9 | 34,420,150 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064386:Ankle Fractures; D005360:Fibula; D005593:Fracture Fixation, Internal; D005594:Fracture Fixation, Intramedullary; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D017695:Soft Tissue Injuries; D013978:Tibial Fractures; D016896:Treatment O... | European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2,022 | |
Metabolic Syndrome-Related Knowledge, Attitudes, and Behavior among Indigenous Communities in Taiwan: A Cross-Sectional Study. | BACKGROUND
Metabolic syndrome is characterized by cardiovascular and chronic disease risk factors that cause health problems. Inequalities in medical resources and information present a challenge in this context. Indigenous communities may be unaware of their risk for metabolic syndrome.
AIMS
This study explored fact... | 10.3390/ijerph20032547 | 36,767,919 | D006801:Humans; D024821:Metabolic Syndrome; D003430:Cross-Sectional Studies; D013624:Taiwan; D007722:Health Knowledge, Attitudes, Practice; D015992:Body Mass Index | International journal of environmental research and public health | 2,023 | |
Phantom visions: real enough to touch. | Blind and partially sighted people are in danger of being wrongly treated for mental health problems. Jane Hart explains the phenomenon known as Charles Bonnet Syndrome. | 10.7748/eldc.9.1.30.s15 | 9,180,451 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness; D005260:Female; D006212:Hallucinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome | Elderly care | 1,997 | |
Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. | OBJECTIVE
To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment.
METHODS
This was a Phase II randomized, double-blind, placebo-controlled, multicenter trial within the Adult AIDS Clinical Trials Group. One-h... | 10.1097/QAD.0b013e32813384e8 | 17,721,095 | D000328:Adult; D044966:Anti-Retroviral Agents; D001921:Brain; D003072:Cognition Disorders; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D015658:HIV Infections; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008559:Mem... | AIDS (London, England) | 2,007 | D044966:Anti-Retroviral Agents; D018691:Excitatory Amino Acid Antagonists; D012367:RNA, Viral; D008559:Memantine |
Brain tumor-scanning agents compared in an animal model. | Sixteen radiopharmaceuticals for brain tumor localization have been compared in a mouse brain tumor model. A rating system is presented for such intercomparison. The rusults indicate that 111-in-chloride injected at pH 1.5 has the most favorable biologic characterisTICS FOR BRAIN TUMOR IMAGING. | 46,273 | D000818:Animals; D001205:Ascorbic Acid; D001761:Bleomycin; D001932:Brain Neoplasms; D002717:Chlormerodrin; D005708:Gallium; D007204:Indium; D007501:Iron; D008629:Mercury Isotopes; D008748:Methylcholanthrene; D051379:Mice; D009368:Neoplasm Transplantation; D004369:Pentetic Acid; D011868:Radioisotopes; D011877:Radionucli... | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 1,975 | D008629:Mercury Isotopes; D011868:Radioisotopes; D012711:Serum Albumin, Radio-Iodinated; D007204:Indium; D001761:Bleomycin; D008748:Methylcholanthrene; D013667:Technetium; D014001:Tin; D004369:Pentetic Acid; D002717:Chlormerodrin; D005708:Gallium; D007501:Iron; D015018:Ytterbium; D001205:Ascorbic Acid | |
Eyelid dermatitis: the rôle of atopy and contact allergy. | Patients with eyelid dermatitis were studied with patch tests and a clinical point method for the diagnosis of atopic skin disease. In 38 patients, contact allergy was found in 11. The dermatitis was an expression of atopic dermatitis in 15 patients. | 10.1111/j.1600-0536.1986.tb01321.x | 3,780,219 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003876:Dermatitis, Atopic; D003877:Dermatitis, Contact; D005141:Eyelid Diseases; D005260:Female; D006229:Hand Dermatoses; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests | Contact dermatitis | 1,986 | |
Private pharmacies in tuberculosis control--a neglected link. | In most settings in India, private pharmacies dispense prescriptions for anti-tuberculosis drugs made out by private practitioners. In a cross-sectional study, we assessed the dispensing practices for tuberculosis and knowledge about the national tuberculosis programme of 300 pharmacies. In all, 2800 prescriptions were... | 11,931,419 | D000995:Antitubercular Agents; D003430:Cross-Sectional Studies; D011307:Drug Prescriptions; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007194:India; D008297:Male; D009313:National Health Programs; D010594:Pharmacies; D011322:Primary Prevention; D017149:Private Sector; D011361:Profes... | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease | 2,002 | D000995:Antitubercular Agents | |
Surgical resection of primary liposarcoma of the anterior mediastinum. | We report on the rare and surgical treatment of a case of primary mediastinal liposarcoma. A 64-year-old male complained of hoarseness for one month and was admitted to our hospital because of an abnormal shadow, which was postulated to be an anterior mediastinal tumor on a chest computed tomography (CT) scan. Horizont... | 18,292,740 | D000971:Antineoplastic Combined Chemotherapy Protocols; D006801:Humans; D008080:Liposarcoma; D008297:Male; D008479:Mediastinal Neoplasms; D008875:Middle Aged; D014057:Tomography, X-Ray Computed | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia | 2,008 | ||
Purification, Characterization, and cDNA Cloning of a Prominent β-Glucosidase from the Gut of the Xylophagous Cockroach Panesthia angustipennis spadica. | In this study, a β-glucosidase (PaBG1b) with high specific activity was purified from gut extracts of the wood-feeding cockroach Panesthia angustipennis spadica using Superdex 75 gel filtration chromatography and High-Trap phenyl hydrophobic chromatography. The protein was purified 14-fold to a single band identified b... | 10.5458/jag.jag.JAG-2016_006 | 34,354,483 | Journal of applied glycoscience | 2,016 | ||
A Java viewer to publish Digital Imaging and Communications in Medicine (DICOM) radiologic images on the World Wide Web. | The world wide web is an exciting service that allows one to publish electronic documents made of text and images on the internet. Client software called a web browser can access these documents, and display and print them. The most popular browsers are currently Microsoft Internet Explorer (Microsoft, Redmond, WA) and... | 10.1007/BF03190349 | 11,442,108 | D006801:Humans; D020407:Internet; D011381:Programming Languages; D011871:Radiology; D012984:Software | Journal of digital imaging | 2,001 | |
Sources of support for women experiencing obstetric fistula in northern Ghana: A focused ethnography. | OBJECTIVE
we explored how women in northern Ghana who have or have had obstetric fistula and those close to them perceive support.
DESIGN
focused ethnography, that includes in-depth interviews, participant observation, and scrutiny of relevant records.
SETTING
a fistula treatment centre in a regional urban centre a... | 27,449,325 | D000328:Adult; D000884:Anthropology, Cultural; D005260:Female; D005378:Financial Support; D005869:Ghana; D006297:Health Services Accessibility; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D036301:Qualitative Research; D012006:Rectovaginal Fistula; D012424:Rural Population; D014719:Vesicovaginal Fistula | Midwifery | 2,016 | ||
Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M. | The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo ima... | 10.1038/s41467-018-03876-8 | 29,670,077 | D000483:Alleles; D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D015850:Interleukin-6; D049449:Luminescence; D051379:Mice; D008810:Mice, Inbred C57BL; D018485:Muscle Fibers, Skeletal; D018482:Muscle... | Nature communications | 2,018 | D015850:Interleukin-6; C577686:interleukin-6, mouse; D053683:Oncostatin M |
Mechanical evaluation of the equine laryngoplasty. | OBJECTIVES
Mechanical evaluation of the equine laryngoplasty.
STUDY DESIGN
Experimental.
ANIMAL POPULATION
Cadaveric cricoid (n=36) and arytenoid (46) cartilages.
METHODS
Arytenoid and cricoid cartilage specimens were embedded for testing. Suture material (2 Ethilon, 5 Ethibond, or 5 Fiberwire) was inserted simul... | 10.1111/j.1532-950X.2010.00701.x | 20,459,484 | D000818:Animals; D001193:Arytenoid Cartilage; D002102:Cadaver; D006736:Horses; D058753:Laryngoplasty; D007830:Larynx; D008422:Materials Testing; D011091:Polyesters; D011093:Polyethylene Terephthalates; D011095:Polyethylenes; D013536:Suture Techniques; D013537:Sutures; D013718:Tensile Strength | Veterinary surgery : VS | 2,010 | C014534:Ethibond; C487884:No. 2 Fiberwire; D011091:Polyesters; D011093:Polyethylene Terephthalates; D011095:Polyethylenes |
Forces produced by lip bumpers on mandibular molars. | The purpose of this study was to measure the forces produced by a lip bumper on the mandibular permanent first molars. The forces in a sample of 38 patients were measured bilaterally with specially designed gauges at rest but with their lips lightly touching, speaking the words church, phone, and pop, and swallowing wa... | 10.1016/s0889-5406(97)70313-5 | 9,199,592 | D000180:Acrylic Resins; D000293:Adolescent; D002508:Cephalometry; D002648:Child; D003679:Deglutition; D003799:Dental Stress Analysis; D005152:Facial Muscles; D005260:Female; D006801:Humans; D008046:Lip; D008297:Male; D008310:Malocclusion; D008334:Mandible; D008963:Molar; D016382:Orthodontic Appliance Design; D009967:Or... | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics | 1,997 | D000180:Acrylic Resins |
Interleukin-37 suppresses the cytotoxicity of hepatitis B virus peptides-induced CD8+ T cells in patients with acute hepatitis B. | Interleukin-37 (IL-37) is a newly identified anti-inflammatory cytokine, owning immunosuppressive activity in infectious diseases. The aim of this study was to investigate the regulatory function of IL-37 on CD8+ T cells during hepatitis B virus (HBV) infection. Eighteen acute hepatitis B (AHB) patients, thirty-nine ch... | 10.17305/bjbms.2022.8260 | 36,326,182 | D006801:Humans; D006515:Hepatitis B virus; D018414:CD8-Positive T-Lymphocytes; D006509:Hepatitis B; D011994:Recombinant Proteins; D007375:Interleukin-1; D000208:Acute Disease; D010455:Peptides; D056945:Hep G2 Cells; D000637:Transaminases | Biomolecules & biomedicine | 2,023 | C508587:IL37 protein, human; D011994:Recombinant Proteins; D007375:Interleukin-1; D010455:Peptides; D000637:Transaminases |
Medical operations in the 21st century: application of TAK among wartime medical assets. | Advances in technology have improved the ability for real-time communication and enhanced awareness of medically related information on the battlefield. A government off-the-shelf platform, Team Awareness Kit (TAK), may enhance the ability for battlefield healthcare delivery, evacuation, telecommunication, and medical ... | 10.1136/military-2023-002400 | 37,400,128 | BMJ military health | 2,023 | ||
The spatial scale of genetic subdivision in populations of Ifremeria nautilei, a hydrothermal-vent gastropod from the southwest Pacific. | BACKGROUND
Deep-sea hydrothermal vents provide patchy, ephemeral habitats for specialized communities of animals that depend on chemoautotrophic primary production. Unlike eastern Pacific hydrothermal vents, where population structure has been studied at large (thousands of kilometres) and small (hundreds of meters) sp... | 10.1186/1471-2148-11-372 | 22,192,622 | D000818:Animals; D004272:DNA, Mitochondrial; D049851:Gastropoda; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D060086:Hydrothermal Vents; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D010140:Pacific Ocean; D017422:Sequence Analysis, DNA | BMC evolutionary biology | 2,011 | D004272:DNA, Mitochondrial; D005819:Genetic Markers |
Discovery of novel SecA inhibitors of Candidatus Liberibacter asiaticus by structure based design. | Candidatus Liberibacter asiaticus is the causal agent of Huanglongbing (HLB) disease of citrus. Current management practices have not been able to control HLB and stop the spread of HLB. The current study is focused on screening small molecule inhibitors against SecA protein of Ca. L. asiaticus. Homology modeling, stru... | 10.1016/j.bmcl.2011.05.086 | 21,684,161 | D000251:Adenosine Triphosphatases; D001426:Bacterial Proteins; D001665:Binding Sites; D003198:Computer Simulation; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D026901:Membrane Transport Proteins; D012230:Rhizobiaceae; D000069816:SEC Translocation Channels; D000081416:SecA Proteins; D054852:Small Molecule... | Bioorganic & medicinal chemistry letters | 2,011 | D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; D054852:Small Molecule Libraries; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins |
Bronchial hysteresis in excised lungs. | 1. Intrapulmonary bronchi in excised dog lungs were outlined with tantalum dust and stereoscopic radiographs taken during deflation and inflation of the lung with air, saline, Ringer or EDTA solutions. Dimensions of airways as a percentage of their values at full inflation were calculated from measurements of the stere... | 10.1113/jphysiol.1975.sp011024 | 1,177,100 | D000818:Animals; D001980:Bronchi; D001995:Bronchography; D004285:Dogs; D066298:In Vitro Techniques; D008168:Lung; D008176:Lung Volume Measurements; D009130:Muscle, Smooth; D011312:Pressure; D013635:Tantalum | The Journal of physiology | 1,975 | D013635:Tantalum |
Diagnostic procedures after a positive spiral computed tomography lung carcinoma screen. | BACKGROUND
Low-radiation dose spiral computed tomography (LDCT) currently is being evaluated as a screening modality for lung carcinoma in a randomized trial. Although several diagnostic algorithms for the workup of positive LDCT screens have been proposed, to the authors' knowledge there is no widely accepted standard... | 10.1002/cncr.20746 | 15,529,306 | D000465:Algorithms; D001706:Biopsy; D002277:Carcinoma; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D013902:Radiography, Thoracic; D036542:Tomography, Spiral Computed | Cancer | 2,005 | |
An assessment of prolonged reactivity of seven monoclonal antibodies against CX-1 tumor xenografts using a hand-held gamma-detecting probe. | The biodistribution and kinetics of 7 monoclonal antibodies (MAb) with known reactivity against CX-1 tumor were examined over 21 days using a hand-held gamma-detecting probe (Neoprobe system). Twenty-eight immuno-deprived (athymic) nude mice implanted with human colon adenocarcinoma CX-1 xenografts were injected intrap... | 10.3109/08941938909057429 | 2,487,252 | D000230:Adenocarcinoma; D000818:Animals; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D003110:Colonic Neoplasms; D005260:Female; D006023:Glycoproteins; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental; D01187... | Journal of investigative surgery : the official journal of the Academy of Surgical Research | 1,989 | D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D006023:Glycoproteins; C047052:tumor-associated antigen 72 |
[Analysis of transcriptional regulatory sites in introns of human and mouse ribosomal protein genes]. | Previous studies from oligonucleotides in the ribosomal protein (RP) genes of the yeast and fruitfly indicated that the potential transcriptional regulatory sites are located in the introns of the genes. The transcriptional regulatory sites in introns are still poorly understood. To explore the functional significance ... | 10.3724/sp.j.1005.2012.01577 | 23,262,105 | D000818:Animals; D001482:Base Composition; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D050436:Regulatory Elements, Transcriptional; D012269:Ribosomal Proteins; D014158:Transcription, Genetic | Yi chuan = Hereditas | 2,012 | D012269:Ribosomal Proteins |
Theory of exciton transfer and diffusion in conjugated polymers. | We describe a theory of Förster-type exciton transfer between conjugated polymers. The theory is built on three assumptions. First, we assume that the low-lying excited states of conjugated polymers are Frenkel excitons coupled to local normal modes, and described by the Frenkel-Holstein model. Second, we assume that t... | 10.1063/1.4897986 | 25,362,268 | The Journal of chemical physics | 2,014 | ||
Difference in sensitivity to alkaline phosphatase treatment between rat reticulocyte membranes in which beta-adrenoceptor desensitization was induced by isoproterenol, dibutyryl cAMP and phorbol ester. | The effect of alkaline phosphatase (3.1.3.1) on desensitization of beta-adrenoceptor-responsive adenylate cyclase and the role of phosphorylation in desensitization were examined. Treatment of rat reticulocytes with isoproterenol, dibutyryl cAMP and tetradecanoyl phorbol acetate (TPA) caused the desensitization of beta... | 10.1016/0922-4106(90)90006-j | 2,163,874 | D000262:Adenylyl Cyclases; D000469:Alkaline Phosphatase; D000535:Aluminum; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D003994:Bucladesine; D002712:Chlorides; D066298:In Vitro Techniques; D007545:Isoproterenol; D007700:Kinetics; D008297:Male; D008566:Membranes; D010766:Phosphorylation; D0... | European journal of pharmacology | 1,990 | D017607:Aluminum Compounds; D002712:Chlorides; D011943:Receptors, Adrenergic, beta; D000077410:Aluminum Chloride; D003994:Bucladesine; D012969:Sodium Fluoride; D000535:Aluminum; D011494:Protein Kinases; D000469:Alkaline Phosphatase; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D013755:Tetradecanoylphorbol Acetate |
The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast. | The G -->T transversion mutation, ade6-M26, creates the heptanucleotide sequence ATGACTG, which lies close to the 5' end of the open reading frame of the ade6 gene in Schizosaccharomyces pombe. The mutation generates a meiosis-specific recombination hot spot and a binding site for the Mts1/Mts2 protein. We examined the... | 10.1101/gad.11.7.876 | 9,106,659 | D002843:Chromatin; D010450:Endopeptidases; D005656:Fungal Proteins; D005800:Genes, Fungal; D008540:Meiosis; D008836:Micrococcal Nuclease; D008957:Models, Genetic; D009687:Nuclear Proteins; D009838:Oligodeoxyribonucleotides; D017354:Point Mutation; D011485:Protein Binding; D016601:RNA-Binding Proteins; D011995:Recombina... | Genes & development | 1,997 | D002843:Chromatin; D005656:Fungal Proteins; C077734:NPL3 protein, S cerevisiae; D009687:Nuclear Proteins; D009838:Oligodeoxyribonucleotides; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C083878:VPS41 protein, S cerevisiae; D033921:Vesicular Transpo... |
Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. | Acapsular (Cap-) mutants of Cryptococcus neoformans var. neoformans that produce melanin (Mel+) on diphenol media at 30 degrees C but not at 37 degrees C were found to be avirulent for mice. Compared with wild-type isolates, the mutants had a lower rate of L-3,4-dihydroxyphenylalanine uptake at 37 degrees C and showed ... | 10.1128/iai.51.1.218-223.1986 | 3,079,732 | D000818:Animals; D003454:Cryptococcus; D003455:Cryptococcus neoformans; D004295:Dihydroxyphenylalanine; D008543:Melanins; D051379:Mice; D014442:Monophenol Monooxygenase | Infection and immunity | 1,986 | D008543:Melanins; D004295:Dihydroxyphenylalanine; D014442:Monophenol Monooxygenase |
Safety of Radioembolization with (90)Yttrium Resin Microspheres Depending on Coiling or No-Coiling of Aberrant/High-Risk Vessels. | PURPOSE
To evaluate the safety of radioembolization (RE) with (90)Yttrium ((90)Y) resin microspheres depending on coiling or no-coiling of aberrant/high-risk vessels.
MATERIALS AND METHODS
Early and late toxicity after 566 RE procedures were analyzed retrospectively in accordance with the National Cancer Institute's ... | 10.1007/s00270-015-1128-x | 25,986,465 | D001918:Brachytherapy; D004621:Embolization, Therapeutic; D006801:Humans; D008099:Liver; D008113:Liver Neoplasms; D008863:Microspheres; D012189:Retrospective Studies; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes | Cardiovascular and interventional radiology | 2,015 | D015021:Yttrium Radioisotopes |
Regioselectivity in C-H activation: reagent control in cyclometallation of 2-(1-naphthyl)-pyridine. | 2-(1-Naphthyl)-pyridine () possesses sp(2) C-H bonds in both the γ- and δ-positions and is therefore a suitable substrate for studying the cyclometallation selectivity with different reagents and conditions. Such selectivity studies are reported. Based on deuterium-exchange experiments it is concluded that cycloruthena... | 10.1039/c5dt04068j | 26,597,047 | Dalton transactions (Cambridge, England : 2003) | 2,016 | ||
Facile Hydrothermal Synthesis of Z-Scheme Bi2Fe4O9/Bi2WO6 Heterojunction Photocatalyst with Enhanced Visible Light Photocatalytic Activity. | An efficient binary Bi2Fe4O9/Bi2WO6 Z-scheme heterojunction was fabricated through a facile hydrothermal route. The obtained Bi2Fe4O9/Bi2WO6 displays high catalytic activity for rhodamine B (RhB) photodegradation, and 100% of RhB was photodegraded by Bi2Fe4O9 (7%)/Bi2WO6 within 90 min, which is much better than that by... | 10.1021/acsami.8b06128 | 29,746,099 | ACS applied materials & interfaces | 2,018 | ||
Laparoscopic Treatment of Slipping Rib Syndrome in Pediatric Patients. | Slipping rib syndrome (SRS) is an often unrecognized cause of lower chest and upper abdominal pain in children and adolescents. Surgical resection of the cartilaginous portions of the slipping rib often provides permanent pain relief, with the standard surgical approach being an open resection. A minimally invasive app... | 10.1089/lap.2020.0314 | 32,955,995 | D015746:Abdominal Pain; D000293:Adolescent; D002356:Cartilage; D002637:Chest Pain; D002648:Child; D059350:Chronic Pain; D002921:Cicatrix; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D019060:Minimally Invasive Surgical Procedures; D019637:Orthopedic Procedures; D059408:Pain... | Journal of laparoendoscopic & advanced surgical techniques. Part A | 2,020 | |
First report of family clusters of Chagas disease seropositive blood donors in Mexico City and their epidemiological relevance. | BACKGROUND
Chagas disease is an important health problem in Latin America. Relatives of T. cruzi seropositive donors could also test positive in serological assays. Therefore, the study of Chagas diseases in family clusters has become important to accurately evaluate the problem that this infectious disease represents.... | 10.1016/j.actatropica.2019.02.014 | 30,771,283 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000913:Antibodies, Protozoan; D001782:Blood Donors; D014355:Chagas Disease; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D... | Acta tropica | 2,019 | D000913:Antibodies, Protozoan |
Study of Endochondral Ossification in Human Fetalcartilage Anlagen of Metacarpals: Comparative Morphology of Mineral Deposition in Cartilage and in the Periosteal Bone Matrix. | The progression of mineral phase deposition in hypertrophic cartilage and periosteal bone matrix was studied in human metacarpals primary ossification centers before vascular invasion began. This study aimed to provide a morphologic/morphometric comparative analysis of the calcification process in cartilage and periost... | 10.1002/ar.23756 | 29,266,881 | D001846:Bone Development; D001857:Bone Matrix; D002113:Calcification, Physiologic; D002356:Cartilage; D006801:Humans; D050279:Metacarpal Bones; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D010521:Periosteum | Anatomical record (Hoboken, N.J. : 2007) | 2,018 | |
Effect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial. | Importance
Endometrial receptivity testing is purported to improve live birth following frozen embryo transfer by identifying the optimal embryo transfer time for an individual patient; however, data are conflicting.
Objective
To compare live birth from single euploid frozen embryo transfer according to endometrial r... | 10.1001/jama.2022.20438 | 36,472,596 | D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D004624:Embryo Transfer; D050498:Live Birth; D012661:Semen; D004717:Endometrium; D013997:Time Factors; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D005307:Fertilization in Vitro; D003955:Diagnostic Tests, Routine | JAMA | 2,022 | |
[Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol]. | The antioxidant and antiradical activities of sulfur containing phenols which are analogues of probucol in comparison with alpha-tocopherol and BHT were tested using initiated methyl oleate oxidation model. The antioxidant effect linearly increased with increasing concentration of phenols. The ability of investigated p... | 11,766,263 | D000975:Antioxidants; D004357:Drug Synergism; D005395:Fish Oils; D005609:Free Radicals; D008163:Luminescent Measurements; D009829:Oleic Acids; D010084:Oxidation-Reduction; D011341:Probucol; D013329:Structure-Activity Relationship; D024502:alpha-Tocopherol | Voprosy meditsinskoi khimii | 2,001 | D000975:Antioxidants; D005395:Fish Oils; D005609:Free Radicals; D009829:Oleic Acids; C443440:bis-(3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propyl)sulfide; C005576:methyl oleate; D024502:alpha-Tocopherol; D011341:Probucol | |
Transesophageal echocardiography. | Two-dimensional transesophageal echocardiography generally has superior sensitivity and image quality compared with precordial echocardiography. Its unique anatomic perspective posterior to the heart often provides important clinical information not obtainable by other imaging approaches and technologies. It is particu... | 10.1016/s0894-7317(88)80013-0 | 3,078,556 | D004452:Echocardiography; D004945:Esophagoscopy; D006331:Heart Diseases; D006801:Humans; D007089:Image Enhancement | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography | 1,988 | |
NEAT1 promotes retinoblastoma progression via modulating miR-124. | The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) is reportedly involved in the initiation and progression of cancers of several types. However, the role, expression status, and the detailed mechanism of NEAT1 in retinoblastoma (RB) yet need to be unraveled. We explored the role and the mechanism of... | 10.1002/jcb.28825 | 31,038,819 | D017209:Apoptosis; D053148:Caspase 3; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012175:Retinoblastoma; D015398:Si... | Journal of cellular biochemistry | 2,019 | C509207:MIRN124 microRNA, human; D035683:MicroRNAs; C577276:NEAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding; C505407:CASP3 protein, human; D053148:Caspase 3 |
The management of postsurgical pain in the elderly population. | It is likely that the trend towards ever more aggressive surgery in elderly and possibly frail patients will continue, with the lifting of traditional age limits. Recent evidence has show that surgical trauma induces processes of nervous system sensitisation that contributes to and enhances postoperative pain and leads... | 10.2165/00002512-199813010-00003 | 9,679,206 | D000368:Aged; D000375:Aging; D000698:Analgesia; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002490:Central Nervous System; D006801:Humans; D009475:Neurons, Afferent; D010149:Pain, Postoperative; D011182:Postoperative Care; D011300:Preoperative Care | Drugs & aging | 1,998 | D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal |
Compartmentalized and internally structured particles for drug delivery--a review. | Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random po... | 10.2174/1381612811319350007 | 23,470,000 | D000818:Animals; D004339:Drug Compounding; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008863:Microspheres; D053758:Nanoparticles; D010316:Particle Size; D004364:Pharmaceutical Preparations; D011108:Polymers; D016062:Porosity; D012822:Silicon Dioxide | Current pharmaceutical design | 2,013 | D004364:Pharmaceutical Preparations; D011108:Polymers; D012822:Silicon Dioxide |
virA and virG are the Ti-plasmid functions required for chemotaxis of Agrobacterium tumefaciens towards acetosyringone. | Octopine and nopaline Ti-plasmids confer upon Agrobacterium tumefaciens C58C1 the ability to respond chemotactically to the vir-inducing phenolic wound exudate, acetosyringone. A. tumefaciens C58C1 containing Ti-plasmids with Tn5 insertions in virB, C, D or E exhibited marked chemotaxis towards acetosyringone. However,... | 10.1111/j.1365-2958.1988.tb00046.x | 3,398,775 | D000098:Acetophenones; D001120:Arginine; D001426:Bacterial Proteins; D002630:Chemotactic Factors; D002633:Chemotaxis; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003360:Cosmids; D005786:Gene Expression Regulation; D008565:Membrane Proteins; D000072236:Methyl-Accepting Chemotaxis Proteins; D009154:Mutation;... | Molecular microbiology | 1,988 | D000098:Acetophenones; D001426:Bacterial Proteins; D002630:Chemotactic Factors; D008565:Membrane Proteins; D000072236:Methyl-Accepting Chemotaxis Proteins; C008666:nopaline; C005394:octopine; C051667:acetosyringone; D001120:Arginine |
Reliability of PCR decontamination systems. | A major problem in the application of PCR is contamination with material amplified previously. Repeated PCRs result in the accumulation of intact and degraded amplicons and primer artifacts that can contaminate following amplification reactions. Post-PCR UV treatment and pre-PCR uracil DNA glycosylase (UDG) digestion h... | 10.1101/gr.4.2.117 | 7,580,883 | D016477:Artifacts; D001483:Base Sequence; D045647:DNA Glycosylases; D017931:DNA Primers; D003666:Decontamination; D005188:False Negative Reactions; D005189:False Positive Reactions; D008969:Molecular Sequence Data; D009699:N-Glycosyl Hydrolases; D016133:Polymerase Chain Reaction; D015203:Reproducibility of Results; D01... | PCR methods and applications | 1,994 | D017931:DNA Primers; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase |
On the shoulders of our mentors: A mentee's perspective on success. | This reflection outlines experiences as a mentee within the field of gerontology, and highlights strategies for students and junior scholars to bolster mentorship opportunities. | 10.1080/02701960.2020.1767609 | 33,166,236 | D005853:Geriatrics; D007722:Health Knowledge, Attitudes, Practice; D006302:Health Services Research; D006801:Humans; D000071252:Mentoring; D008611:Mentors | Gerontology & geriatrics education | 2,020 | |
Genetic variations in G-protein signal pathways influence progression of coronary artery calcification: Results from the Heinz Nixdorf Recall study. | BACKGROUND AND AIMS
Coronary artery calcification (CAC) is one of the most sensitive and specific markers of coronary atherosclerosis and believed to be heritable. We hypothesized that functionally relevant single-nucleotide polymorphisms (SNPs) in the G-protein signal pathway, which have been previously related to cor... | 10.1016/j.atherosclerosis.2020.06.020 | 32,680,596 | D003324:Coronary Artery Disease; D018450:Disease Progression; D019204:GTP-Binding Proteins; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015398:Signal Transduction; D061205:Vascular Calcification | Atherosclerosis | 2,020 | D019204:GTP-Binding Proteins |
Infection of a simian B cell line by human and simian immunodeficiency viruses. | It is well known that HIV-1 does not establish infection in nonhuman primates, nor in cell lines derived from them, due to the existence of saturable resistance factors. In this study, we show that an in vitro established Macaca fascicularis-derived CD4(-) B cell line (F6) can be productively infected by the laboratory... | 10.1089/0889222041524652 | 15,307,918 | D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes; D015496:CD4-Positive T-Lymphocytes; D002460:Cell Line; D005434:Flow Cytometry; D015497:HIV-1; D006801:Humans; D008252:Macaca fascicularis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015302:Simian Immunodeficiency Virus; D013045:Species Specifi... | AIDS research and human retroviruses | 2,004 | D015703:Antigens, CD |
[Panniculitis revealing alpha-1 antitrypsin deficiency. Report of 3 cases]. | We report panniculitis revealing alpha-1 antitrypsin deficiency in 3 patients with different Pi phenotypes. The first patient, a 16-year-old woman, had inflammatory skin lesions on the abdomen for 6 months. The lesions regressed spontaneously. Serum alph-1 antitrypsin level was normal but the Pi phenotype was MS. The s... | 11,937,984 | D000005:Abdomen; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007866:Leg; D008875:Middle Aged; D015434:Panniculitis; D010641:Phenotype; D019896:alpha 1-Antitrypsin Deficiency | Annales de medecine interne | 2,001 | ||
Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. | Neuropathic pain is a chronic pain syndrome that arises from nerve injury. Current treatments only offer limited relief, clearly indicating the need for more effective therapeutic strategies. Previously, we demonstrated that proinflammatory tumor necrosis factor-alpha (TNF) is a key mediator of neuropathic pain pathoge... | 10.1097/j.pain.0000000000000181 | 25,851,457 | D000818:Animals; D003250:Constriction; D006624:Hippocampus; D008297:Male; D050997:Nanomedicine; D043942:Nanotubes; D059226:Nociceptive Pain; D034741:RNA, Small Interfering; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha | Pain | 2,015 | D034741:RNA, Small Interfering; D014409:Tumor Necrosis Factor-alpha |
Wideband compressive beamforming tomography for drive-by large-scale acoustic source mapping. | Noise-mapping is an effective sound visualization tool for the identification of urban noise hotspots, which is crucial to taking targeted measures to tackle environmental noise pollution. This paper develops a high-resolution wideband acoustic source mapping methodology using a portable microphone array, where the joi... | 10.1121/1.5042214 | 29,960,419 | The Journal of the Acoustical Society of America | 2,018 | ||
Various Properties of Silicone Breast Implant Surfaces and Multimodal Techniques for the Functional Surface Modification. | "Silicone breast implants are the most widely used medical devices for breast reconstruction and augmentation, and revision, but even after more than 60 years of use they are associated with multiple continued complications. Using advancement in current technologies, researchers are attempting to create an optimal impl... | 10.1016/j.cps.2020.08.003 | 33,220,908 | D018427:Breast Implants; D005260:Female; D006801:Humans; D011474:Prosthesis Design; D020034:Silicone Gels; D013499:Surface Properties | Clinics in plastic surgery | 2,021 | D020034:Silicone Gels |
Vocabulary production in toddlers from low-income immigrant families: evidence from children exposed to Romanian-Italian and Nigerian English-Italian. | The relationship between first and second language in early vocabulary acquisition in bilingual children is still debated in the literature. This study compared the expressive vocabulary of 39 equivalently low-SES two-year-old bilingual children from immigrant families with different heritage languages (Romanian vs. Ni... | 10.1017/S0305000921000222 | 33,884,950 | D002675:Child, Preschool; D054242:Emigrants and Immigrants; D006801:Humans; D007802:Language; D007804:Language Development; D019303:Multilingualism; D009549:Nigeria; D012383:Romania; D014825:Vocabulary | Journal of child language | 2,022 | |
Learning from the research process: An advanced practitioner reporting radiographer reflective narrative. | Research is one of the recognized four pillars of advanced practice. This reflective narrative outlines the radiographer author's critical thoughts throughout the completion of the research modules for an MSc in Clinical reporting. The journey is followed from formative stages through to completion. Skills are develope... | 10.1016/j.jmir.2022.04.049 | 35,514,014 | D000488:Allied Health Personnel; D006801:Humans; D007857:Leadership | Journal of medical imaging and radiation sciences | 2,022 | |
Early deviation from normal structural connectivity: A novel intrinsic severity score for mild TBI. | OBJECTIVE
Studies of outcome after traumatic brain injury (TBI) are hampered by the lack of robust injury severity measures that can accommodate spatial-anatomical and mechanistic heterogeneity. In this study we introduce a Mahalanobis distance measure (M) as an intrinsic injury severity measure that combines in a sing... | 10.1212/WNL.0000000000008902 | 31,937,623 | D000328:Adult; D001924:Brain Concussion; D060825:Cognitive Dysfunction; D056324:Diffusion Tensor Imaging; D006801:Humans; D009415:Nerve Net; D012720:Severity of Illness Index; D066127:White Matter | Neurology | 2,020 | |
Developing a Copper(II) Agent Based on His-146 and His-242 Residues of Human Serum Albumin Nanoparticles: Integration To Overcome Cisplatin Resistance and Inhibit the Metastasis of Nonsmall Cell Lung Cancer. | To overcome the resistance of nonsmall cell lung cancer (NSCLC) cells to cisplatin and inhibit their metastasis, we proposed to develop a Cu(II) agent based on the specific residue(s) of HSA nanoparticles (NPs) for multitargeting the tumor microenvironment (TME). To this end, we not only synthesized four Cu(II) 2-hydro... | 10.1021/acs.jmedchem.2c00698 | 35,786,921 | D000970:Antineoplastic Agents; D002289:Carcinoma, Non-Small-Cell Lung; D045744:Cell Line, Tumor; D002945:Cisplatin; D003300:Copper; D006801:Humans; D008175:Lung Neoplasms; D053758:Nanoparticles; D000075462:Serum Albumin, Human; D059016:Tumor Microenvironment | Journal of medicinal chemistry | 2,022 | D000970:Antineoplastic Agents; D003300:Copper; D002945:Cisplatin; D000075462:Serum Albumin, Human |
DeeProPre: A promoter predictor based on deep learning. | The promoter is a DNA sequence recognized, bound and transcribed by RNA polymerase. It is usually located at the upstream or 5'end of the transcription start site (TSS). Studies have shown that the structure of the promoter affects its affinity for RNA polymerase, thus affecting the level of gene expression. Therefore,... | 10.1016/j.compbiolchem.2022.107770 | 36,116,322 | D000077321:Deep Learning; D016571:Neural Networks, Computer; D000465:Algorithms; D012984:Software; D011401:Promoter Regions, Genetic | Computational biology and chemistry | 2,022 | |
Tropical pyomyositis: a case report and review. | Tropical pyomyositis is a disease of skeletal muscle characterized by single or multiple abscesses. The infective organism is most often penicillin-resistant Staphylococcus aureus. Only recently have case reports appeared in the literature from temperate zones; however, this disease is common in the tropics. This repor... | 440,823 | D000038:Abscess; D000328:Adult; D006801:Humans; D008297:Male; D008712:Methicillin; D008826:Microbial Sensitivity Tests; D009220:Myositis; D011859:Radiography; D013203:Staphylococcal Infections; D014640:Vancomycin | Pediatrics | 1,979 | D014640:Vancomycin; D008712:Methicillin | |
Rehabilitation for the head and neck cancer patient. | As the economics of health care increasingly dictate the parameters of patient care delivery, the role of rehabilitation has taken on new meaning with regard to positive patient outcomes. This is particularly true for the head and neck cancer patient coping with devastating physical and functional changes. With treatme... | 9,474,589 | D002294:Carcinoma, Squamous Cell; D003679:Deglutition; D006258:Head and Neck Neoplasms; D006801:Humans; D010351:Patient Discharge; D010353:Patient Education as Topic; D012046:Rehabilitation; D012648:Self Care; D013060:Speech | Oncology (Williston Park, N.Y.) | 1,998 | ||
Immune Checkpoint Receptors Signaling in T Cells. | The characterization of the receptors negatively modulating lymphocyte function is rapidly advancing, driven by success in tumor immunotherapy. As a result, the number of immune checkpoint receptors characterized from a functional perspective and targeted by innovative drugs continues to expand. This review focuses on ... | 10.3390/ijms23073529 | 35,408,889 | D019852:Diacylglycerol Kinase; D010744:Phosphoric Monoester Hydrolases; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases; D011971:Receptors, Immunologic; D013601:T-Lymphocytes; D014443:Tyrosine | International journal of molecular sciences | 2,022 | D011971:Receptors, Immunologic; D014443:Tyrosine; D019852:Diacylglycerol Kinase; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase; D017027:Protein Tyrosine Phosphatases |
Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i. | INTRODUCTION
A high proportion of Canadian patients with acute myocardial infarction (AMI) do not achieve the threshold low-density lipoprotein cholesterol (LDL-C) levels recommended by the Canadian Cardiovascular Society in 2021. This increases the risk of subsequent atherosclerotic cardiovascular disease (ASCVD) even... | 10.1007/s40119-022-00300-7 | 36,656,500 | Cardiology and therapy | 2,023 | ||
Revisiting the Environment Effect on Mass Transfer for Heterogenized Pd6 Ru8 Metal-Organic Cage Photocatalyst Confined within 3D Matrix. | Artificial light-driven splitting of water into hydrogen involves multiple links to emulate natural photosynthesis, including light absorption, electron or energy transfer, surface catalysis et al., in which, the mass transportation of sacrificial reagent and reactant is always ignored. Metal-organic cage (MOC) of Pd6 ... | 10.1002/chem.202200310 | 35,482,818 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,022 | ||
Hypocaloric parenteral nutrition support in elderly obese patients. | Hypocaloric nutritional support has been successfully used to achieve positive nitrogen balance in obese patients. However, advanced age is associated with changes in substrate metabolism. To evaluate the efficacy of this practice in elderly patients, we retrospectively reviewed 30 obese patients requiring parenteral n... | 10,776,878 | D000328:Adult; D000367:Age Factors; D000368:Aged; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen; D009765:Obesity; D010288:Parenteral Nutrition; D018579:Patient Selection; D011506:Proteins; D012189:Retrospective Studies | The American surgeon | 2,000 | D011506:Proteins; D009584:Nitrogen | |
p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. | The well-established association between TP53 mutations and adverse clinical outcome in a range of human cancers reflects the importance of p53 protein in regulating tumor-cell growth and survival. Although it is theoretically possible for p53 dysfunction to arise through mechanisms that do not involve TP53 mutation, s... | 10.1182/blood.v98.3.814 | 11,468,183 | D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D016923:Cell Death; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D016158:Genes, p53; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D007963:Leukocytes, Mononuclear; D009154:Mutation; D009687:Nuclear Protei... | Blood | 2,001 | D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mu... |
A functional leptin system is essential for sodium tungstate antiobesity action. | Sodium tungstate is a novel agent in the treatment of obesity. In diet-induced obese rats, it is able to reduce body weight gain by increasing energy expenditure. This study evaluated the role of leptin, a key regulator of energy homeostasis, in the tungstate antiobesity effect. Leptin receptor-deficient Zucker fa/fa r... | 10.1210/en.2008-0881 | 18,845,634 | D000273:Adipose Tissue; D002001:Adipose Tissue, Brown; D050154:Adiposity; D000818:Animals; D019440:Anti-Obesity Agents; D001835:Body Weight; D004734:Energy Metabolism; D020869:Gene Expression Profiling; D020738:Leptin; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009479:Neuropeptides; D009765:Obesity; D051381:Rats... | Endocrinology | 2,009 | D019440:Anti-Obesity Agents; D020738:Leptin; D009479:Neuropeptides; D017973:Tungsten Compounds; C025399:sodium tungstate(VI) |
Long-term effects of developmental exposure to low doses of PCB 126 and methylmercury. | Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are food contaminants often found in fish. Experimental and epidemiological studies indicate that both PCBs and MeHg are developmental neurotoxicants, and some reports suggest that they may cause additive and/or synergistic neurotoxicity. We had previously inves... | 10.1016/j.toxlet.2010.04.024 | 20,450,966 | D000818:Animals; D001522:Behavior, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D048788:Growth and Development; D008297:Male; D008767:Methylmercury Compounds; D011078:Polychlorinated Biphenyls; D051381:Rats; D017208:Rats, Wistar; D013995:Time; D014874:Water Pollutants, Chemical | Toxicology letters | 2,010 | D008767:Methylmercury Compounds; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl |
The Role of Depression Screening and Treatment in Achieving the UNAIDS 90-90-90 Goals in Sub-Saharan Africa. | Despite widespread HIV screening and treatment programs across sub-Saharan Africa, many countries are not on course to meet the Joint United Nations Program on HIV/AIDS 90-90-90 targets. As mental health disorders such as depression are prevalent among people living with HIV, investment in understanding and addressing ... | 10.1007/s10461-019-02593-7 | 31,317,365 | D017954:Africa South of the Sahara; D000928:Antidepressive Agents; D003153:Community Health Services; D003266:Continuity of Patient Care; D019033:Delivery of Health Care, Integrated; D003863:Depression; D003866:Depressive Disorder; D006040:Goals; D015658:HIV Infections; D006801:Humans; D008403:Mass Screening; D055118:M... | AIDS and behavior | 2,019 | D000928:Antidepressive Agents |
Invisible Surface Oxygen Vacancies in a Thin MgO Film: Impacts on the Chemical Activity and Secondary Electron Emission. | Today, Fs defects in MgO as isolated surface neutral oxygen vacancies are in the focus of surface science, catalysis research, and emission coating of microchannel plates. With the 10-4 atom % content at 750 K and under pO = 10-9 Torr, estimated by us from the known equilibrium T-x and p-T-x diagrams of MgO, Fs defects... | 10.1021/acs.inorgchem.0c02351 | 33,269,923 | Inorganic chemistry | 2,020 | ||
New chemical and radiochemical routes to [18F]Rho6G-DEG-F, a delocalized lipophilic cation for myocardial perfusion imaging with PET. | New chemical and radiochemical syntheses are described for the preparation of [18F]Rho6G-DEG-F, an 18F-labeled analogue of the fluoresecent dye rhodamine 6G, which has shown promise as myocardidal perfusion imaging agent. Tosylated precursors of [18F]Rho6G-DEG-F amenable to 18F-labeling were obtained either through a t... | 10.1039/C7MD00326A | 29,276,578 | MedChemComm | 2,017 | ||
Living With Chronic Pain After Spinal Cord Injury: A Mixed-Methods Study. | OBJECTIVE
To identify the relative importance of positive (facilitators) and negative (barriers) contributors to living with chronic pain after spinal cord injury (SCI).
DESIGN
Mixed-methods: (1) Qualitative (n=35): individual, semistructured, open-ended interviews identifying facilitator/barrier themes; (2) Quantita... | 10.1016/j.apmr.2016.10.018 | 27,894,730 | D000223:Adaptation, Psychological; D000328:Adult; D000367:Age Factors; D000700:Analgesics; D059350:Chronic Pain; D003142:Communication; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D059408:Pain Management; D010353:Patient Education as Topic; D011788:Quality of Life; D0... | Archives of physical medicine and rehabilitation | 2,017 | D000700:Analgesics |
Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro. | Circular RNAs (circRNAs) are crucial in gene regulatory networks and disease development, yet circRNA expression in myocardial infarction (MI) is poorly understood. Here, we harvested myocardium samples from domestic pigs 3 days after closed-chest reperfused MI or sham surgery. Cardiac circRNAs were identified by RNA-s... | 10.3390/ijms22031390 | 33,573,240 | D000818:Animals; D015687:Cell Hypoxia; D019295:Computational Biology; D017023:Coronary Angiography; D004195:Disease Models, Animal; D015536:Down-Regulation; D005260:Female; D053263:Gene Regulatory Networks; D006801:Humans; D032386:Myoblasts, Cardiac; D009203:Myocardial Infarction; D015428:Myocardial Reperfusion Injury;... | International journal of molecular sciences | 2,021 | D000079962:RNA, Circular |
Vertebral artery reconstruction. A successful technique in selected patients. | Fourteen patients were selected to have a total of 15 vertebral artery reconstructions in a four-year period. They all had incapacitating neurologic symptoms, and detailed investigations had been done to rule out other possible causes. If more than one lesion was present in the angiogram, priority was given to the reco... | 10.1097/00000658-198104000-00008 | 7,212,807 | D000368:Aged; D001157:Arterial Occlusive Diseases; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries; D003251:Constriction, Pathologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012092:Replantation; D012501:Saphenous Vein; D013348:Subclavian Artery; D014711:V... | Annals of surgery | 1,981 | |
Retracted: Effect of Grading Rehabilitation Nursing Mode on Limb Function, Speech Rehabilitation, and Quality of Life of Stroke Patients. | [This retracts the article DOI: 10.1155/2022/6956406.]. | 10.1155/2023/9825301 | 37,387,939 | Evidence-based complementary and alternative medicine : eCAM | 2,023 | ||
Optical assays based on colloidal inorganic nanoparticles. | Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20 nm diameter size range) to undergo a color change from red to blue upon aggregation. AuNP assays can be based on cros... | 10.1039/c8an00731d | 29,924,108 | D003124:Colorimetry; D006046:Gold; D053768:Metal Nanoparticles; D053761:Nanocomposites; D012822:Silicon Dioxide; D012834:Silver | The Analyst | 2,018 | D012834:Silver; D006046:Gold; D012822:Silicon Dioxide |
The impact of consumer phase models in microbial risk analysis. | In quantitative microbiological risk assessment (QMRA), the consumer phase model (CPM) describes the part of the food chain between purchase of the food product at retail and exposure. Construction of a CPM is complicated by the large variation in consumer food handling practices and a limited availability of data. The... | 10.1111/j.1539-6924.2010.01481.x | 20,738,819 | D000818:Animals; D002167:Campylobacter; D002645:Chickens; D008962:Models, Theoretical; D016012:Poisson Distribution; D011202:Poultry Products; D011336:Probability; D018570:Risk Assessment; D040242:Risk Reduction Behavior | Risk analysis : an official publication of the Society for Risk Analysis | 2,011 | |
CDKN2A deletion in pediatric versus adult glioblastomas and predictive value of p16 immunohistochemistry. | Cell cycle regulator genes are major target of mutation in many human malignancies including glioblastomas (GBMs). CDKN2A is one such tumor suppressor gene which encodes p16INK4a protein and serves as an inhibitor of cell cycle progression. Very few studies are available regarding the association of CDKN2A deletion wit... | 10.1111/neup.12014 | 23,311,918 | D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms; D002648:Child; D002675:Child, Preschool; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D017353:Gene Deletion; D019942:Genes, p16; D005909:Glioblastoma; D006801:Humans; D007150:Immu... | Neuropathology : official journal of the Japanese Society of Neuropathology | 2,013 | D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16 |
A fuzzy decision-making system for video tracking with multiple objects in non-stationary conditions. | Computer vision remains challenged by tracking multiple objects in motion frames, despite efforts to improve surveillance, healthcare, and human-machine interaction. This paper presents a method for monitoring several moving objects in non-stationary settings for autonomous navigation. Additionally, at each phase, move... | 10.1016/j.heliyon.2023.e22156 | 38,034,808 | Heliyon | 2,023 | ||
Differential effects of anoxia and glutamate on cultured neocortical neurons. | That glutamate increases in the extracellular space of the brain during hypoxia or ischemia and that this amino acid, in high enough concentrations, kills neurons has led investigators to use glutamate and study the mechanisms underlying neuronal excitotoxicity as a model for acute cell death that occurs with low oxyge... | 10.1006/exnr.1997.6764 | 9,514,836 | D000255:Adenosine Triphosphate; D000818:Animals; D017209:Apoptosis; D002118:Calcium; D015687:Cell Hypoxia; D048429:Cell Size; D002478:Cells, Cultured; D018698:Glutamic Acid; D017136:Ion Transport; D008959:Models, Neurological; D019579:Neocortex; D009474:Neurons; D009498:Neurotoxins; D010100:Oxygen; D051381:Rats; D01720... | Experimental neurology | 1,998 | D009498:Neurotoxins; D018698:Glutamic Acid; D000255:Adenosine Triphosphate; D010100:Oxygen; D002118:Calcium |
Cancer immunosurveillance by gut T cells. | T cells primed in the gut influence immune responses to extraintestinal tumors. | 10.1126/science.adi3357 | 37,289,885 | D006801:Humans; D009369:Neoplasms; D013601:T-Lymphocytes; D007157:Immunologic Surveillance; D041981:Gastrointestinal Tract; D000818:Animals; D051379:Mice | Science (New York, N.Y.) | 2,023 | |
Kinase inhibitor selectivity profiling using differential scanning fluorimetry. | Fast, robust, and inexpensive screening methods are the heart of drug discovery processes. Moreover, it is useful to have access to several established assay formats, for validation purposes. If a targeted protein is an enzyme, the logical and widely used approach is the direct measurement of the effect of the added li... | 10.1007/978-1-61779-337-0_7 | 21,960,218 | D057075:Enzyme Assays; D005470:Fluorometry; D057166:High-Throughput Screening Assays; D008024:Ligands; D011485:Protein Binding; D047428:Protein Kinase Inhibitors; D055550:Protein Stability; D013379:Substrate Specificity | Methods in molecular biology (Clifton, N.J.) | 2,012 | D008024:Ligands; D047428:Protein Kinase Inhibitors |
Detachment of retinal pigment epithelium in retinopathy due to malaria. | CASE REPORT
A 45-year-old man was diagnosed with malaria with neurological involvement. Two months later he referred metamorphopsia in the left eye. Malarial retinopathy was observed in the fundus examination. The Optic Coherence Tomography (OCT) of the macula showed parafoveal pigment epithelium detachment (DEP). Spec... | 10.1016/j.oftal.2018.03.005 | 29,807,845 | D000962:Antimalarials; D002596:Chad; D004318:Doxycycline; D004912:Erythrocytes; D005451:Fluorescein Angiography; D006801:Humans; D016779:Malaria, Cerebral; D016778:Malaria, Falciparum; D008297:Male; D008875:Middle Aged; D011241:Prednisone; D011802:Quinidine; D011803:Quinine; D012163:Retinal Detachment; D012166:Retinal ... | Archivos de la Sociedad Espanola de Oftalmologia | 2,018 | D000962:Antimalarials; D011803:Quinine; D011802:Quinidine; D004318:Doxycycline; C016713:quinidine gluconate; D011241:Prednisone |
The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review. | Background and aim
Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) with a... | 10.1016/j.jtcme.2022.10.004 | 36,685,079 | Journal of traditional and complementary medicine | 2,023 | ||
Lactational exposure to methylmercury in the hamster. | Syrian Golden hamster dams were administered 203Hg-labelled methyl mercury (MeHg; 1.6 mumol/kg) 1 day after parturition and milk was collected twice during the 1st week. The excretion of 203Hg in milk and the uptake, retention and tissue distribution of 203Hg in the pups was studied using gamma counting. The fraction o... | 10.1007/s002040050164 | 7,755,483 | D000818:Animals; D000833:Animals, Suckling; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D008722:Methods; D008767:Methylmercury Compounds; D008892:Milk | Archives of toxicology | 1,995 | D008767:Methylmercury Compounds; C004925:methylmercuric chloride |
Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study. | Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this study is to investigate how the cerebral 5-HT system associates to disturbanc... | 10.3390/brainsci12050654 | 35,625,040 | Brain sciences | 2,022 | ||
Control of neural chaos by synaptic noise. | We study neural automata - or neurobiologically inspired cellular automata - which exhibits chaotic itinerancy among the different stored patterns or memories. This is a consequence of activity-dependent synaptic fluctuations, which continuously destabilize the attractor and induce irregular hopping to other possible a... | 10.1016/j.biosystems.2006.09.013 | 17,084,962 | D000465:Algorithms; D003198:Computer Simulation; D008959:Models, Neurological; D009010:Monte Carlo Method; D009415:Nerve Net; D016571:Neural Networks, Computer; D017711:Nonlinear Dynamics; D013569:Synapses; D049490:Systems Biology | Bio Systems | 2,007 | |
Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. | Overexpression of matrix metalloproteinases (MMPs) is a major pathological factor causing cartilage destruction in osteoarthritis (OA). This study aimed to investigate the effects and mechanisms of sesamol on expression of MMPs in activated chondrosarcoma cells. Sesamol significantly attenuated TNF-α- and IL-1β-induced... | 10.1021/jf1046738 | 21,428,299 | D000818:Animals; D052117:Benzodioxoles; D045744:Cell Line, Tumor; D019902:Chondrocytes; D004195:Disease Models, Animal; D015536:Down-Regulation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases; D016328:NF-kappa B; D010003:Osteoarthritis; D010636:Phenols; ... | Journal of agricultural and food chemistry | 2,011 | D052117:Benzodioxoles; D016328:NF-kappa B; D010636:Phenols; D020011:Protective Agents; C025583:sesamol; D020782:Matrix Metalloproteinases |
Curcumin-Polyethylene Glycol Loaded on Chitosan-Gelatin Nanoparticles Enhances Burn Wound Healing in Rat. | The aim of the present study was to evaluate effects of curcumin-polyethylene glycol loaded on chitosan-gelatin nanoparticles (C-PEG-CGNPs) on burn wound healing in rat as a model study. Sixty healthy male White Wistar rats were randomized into four experimental groups of 15 animals each: Control group (Control) was tr... | 10.1093/jbcr/irac048 | 35,420,679 | D051381:Rats; D008297:Male; D000818:Animals; D012837:Silver Sulfadiazine; D048271:Chitosan; D002056:Burns; D005780:Gelatin; D003474:Curcumin; D053148:Caspase 3; D009824:Ointments; D011092:Polyethylene Glycols; D016159:Tumor Suppressor Protein p53; D017208:Rats, Wistar; D014945:Wound Healing; D053758:Nanoparticles; D019... | Journal of burn care & research : official publication of the American Burn Association | 2,022 | D012837:Silver Sulfadiazine; D048271:Chitosan; D005780:Gelatin; D003474:Curcumin; D053148:Caspase 3; D009824:Ointments; D011092:Polyethylene Glycols; D016159:Tumor Suppressor Protein p53; D019253:Proto-Oncogene Proteins c-bcl-2 |
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