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Controlled fed-batch fermentations of dilute-acid hydrolysate in pilot development unit scale. | Inhibitors formed during wood hydrolysis constitute a major problem in fermenting dilute-acid hydrolysates. By applying a fed-batch technique, the levels of inhibitory compounds may be held low, enabling high ethanol productivity. In this study, a previously developed fed-batch strategy was modified and implemented for... | 10.1385/abab:114:1-3:601 | 15,054,280 | D000143:Acids; D000465:Algorithms; D018533:Biomass; D019149:Bioreactors; D001709:Biotechnology; D002245:Carbon Dioxide; D002470:Cell Survival; D002482:Cellulose; D000431:Ethanol; D005285:Fermentation; D006601:Hexoses; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D015233:Models, Statistical; D012441:Saccharom... | Applied biochemistry and biotechnology | 2,004 | D000143:Acids; D006601:Hexoses; D002245:Carbon Dioxide; D000431:Ethanol; D002482:Cellulose |
Is the acetylcholine releasing protein mediatophore present in rat brain? | Mediatophore is a protein purified from the nerve terminal membranes of Torpedo electric organ. It confers to artificial membranes a calcium-dependent mechanism that translocates acetylcholine. When similar reconstitution experiments are applied to rat brain synaptosomal membranes they reveal the presence of mediatopho... | 10.1016/0014-5793(88)80475-7 | 3,384,100 | D000109:Acetylcholine; D000818:Animals; D001921:Brain; D008081:Liposomes; D008297:Male; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins; D011510:Proteolipids; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes; D013574:Synaptosomes | FEBS letters | 1,988 | D008081:Liposomes; D009419:Nerve Tissue Proteins; D011510:Proteolipids; C050299:mediatophore; C020485:proteoliposomes; D000109:Acetylcholine |
Complex optical constants on a subwavelength scale. | Optical phase contrast has for the first time been observed on a nanometer scale, with a near-field microscope of scattering type that maps the complete optical field of amplitude and phase. Backed by quasielectrostatic theory, we demonstrate the significance and experimental accessibility of even complex optical const... | 10.1103/PhysRevLett.85.3029 | 11,005,995 | Physical review letters | 2,000 | ||
PD Control-Based Reachable Set Synthesis for Singular Takagi-Sugeno Fuzzy Systems With Time-Varying Delay. | This article focuses on the reachable set synthesis problem for singular Takagi-Sugeno fuzzy systems with time-varying delay. The main contribution is that we design a proportional plus derivative state feedback controller to ensure that the singular fuzzy system is normal and the system states are bounded by a derived... | 10.1109/TCYB.2022.3210184 | 36,256,713 | IEEE transactions on cybernetics | 2,022 | ||
Analys. DNA: a computer program for nucleic acid sequence data processing. | A computer program written in BASIC language is described. The program allows processing and analysis of DNA data and has been designed to be used by persons with little or no computer experience. The operator using different options can search for direct homologies with varying degrees of matching, generate complement... | 6,097,194 | D000818:Animals; D001483:Base Sequence; D003201:Computers; D004247:DNA; D004262:DNA Restriction Enzymes; D004272:DNA, Mitochondrial; D006054:Goldfish; D006801:Humans; D012984:Software | Archivos de biologia y medicina experimentales | 1,984 | D004272:DNA, Mitochondrial; D004247:DNA; D004262:DNA Restriction Enzymes | |
Capsule endoscopy in refractory celiac disease. | BACKGROUND AND STUDY AIMS
Patients with refractory celiac disease (RCD) are at risk of intestinal T-cell lymphoma, which is difficult to diagnose because it often develops in the small bowel. We therefore studied whether wireless capsule endoscopy was able to detect ulcerative jejunitis or intestinal T-cell lymphomas t... | 10.1055/s-2007-966239 | 17,516,353 | D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy; D002446:Celiac Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms; D007579:Jejunal Diseases; D008198:Lymph Nodes; D016399:Lymphoma, T-Cell; D008297:Male; D008643:Mesentery; D008875:Middle Aged; D012189:Retrospect... | Endoscopy | 2,007 | |
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6. | Nuclear receptor coactivator 6 (NCOA6) is a transcriptional coactivator of nuclear receptors and other transcription factors. A general Ncoa6 knockout mouse was previously shown to be embryonic lethal, but we here generated liver-specific Ncoa6 knockout (Ncoa6 LKO) mice to investigate the metabolic function of NCOA6 in... | 10.14348/molcells.2022.2222 | 35,258,009 | D000818:Animals; D005576:Colforsin; D017362:Cyclic AMP Response Element-Binding Protein; D005943:Gluconeogenesis; D005947:Glucose; D005952:Glucose-6-Phosphatase; D022781:Hepatocytes; D008099:Liver; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D056918:Nuclear Receptor Coactivators; D000071248:Peroxi... | Molecules and cells | 2,022 | D017362:Cyclic AMP Response Element-Binding Protein; C405683:Ncoa6 protein, mouse; D056918:Nuclear Receptor Coactivators; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D005576:Colforsin; D019289:Pyruvic Acid; D005952:Glucose-6-Phosphatase; D005947:Glucose |
Toxic effects of bisphenol A on sexual and asexual reproduction in Hydra oligactis. | Hydra oligactis, an evolutionarily primitive invertebrate, produced eggs or testes (sexual reproduction) when starved at 10 degrees C, and produced buds (asexual reproduction) when fed at 20 degrees C. Bisphenol A (BPA) at 2-4 mg/L given to male or female hydra had adverse effects on both sexual and asexual reproductio... | 10.1007/s00244-004-0032-1 | 15,886,896 | D000818:Animals; D001559:Benzhydryl Compounds; D004305:Dose-Response Relationship, Drug; D004968:Estrogens, Non-Steroidal; D005260:Female; D006829:Hydra; D008297:Male; D010063:Ovum; D010636:Phenols; D012098:Reproduction; D012100:Reproduction, Asexual; D013696:Temperature; D013737:Testis; D014874:Water Pollutants, Chemi... | Archives of environmental contamination and toxicology | 2,005 | D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D014874:Water Pollutants, Chemical; C006780:bisphenol A |
Many dissimilar NusG protein domains switch between α-helix and β-sheet folds. | Folded proteins are assumed to be built upon fixed scaffolds of secondary structure, α-helices and β-sheets. Experimentally determined structures of >58,000 non-redundant proteins support this assumption, though it has recently been challenged by ~100 fold-switching proteins. Though ostensibly rare, these proteins rais... | 10.1038/s41467-022-31532-9 | 35,778,397 | D000595:Amino Acid Sequence; D000072756:Protein Conformation, alpha-Helical; D000072757:Protein Conformation, beta-Strand; D000072417:Protein Domains; D014157:Transcription Factors | Nature communications | 2,022 | D014157:Transcription Factors |
The Role of MET in Resistance to EGFR Inhibition in NSCLC: A Review of Mechanisms and Treatment Implications. | Utilizing targeted therapy against activating mutations has opened a new era of treatment paradigms for patients with advanced non-small cell lung cancer (NSCLC). For patients with epidermal growth factor (EGFR)-mutated cancers, EGFR inhibitors, including the third-generation tyrosine kinase inhibitor (TKI) osimertinib... | 10.3390/cancers15112998 | 37,296,959 | Cancers | 2,023 | ||
Secondary Use of Clinical Data to Enable Data-Driven Translational Science with Trustworthy Access Management. | University of Missouri (MU) Health Care produces a large amount of digitized clinical data that can be used in clinical and translational research for cohort identification, retrospective data analysis, feasibility study, and hypothesis generation. In this article, the implementation of an integrated clinical research ... | 26,821,445 | D000046:Academic Medical Centers; D019992:Databases as Topic; D057286:Electronic Health Records; D006801:Humans; D008490:Medical Informatics; D008923:Missouri; D057170:Translational Research, Biomedical | Missouri medicine | 2,015 | ||
Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression. | BACKGROUND
The androgen-regulated probasin (PB) promoter has been used extensively to target transgenes to the prostate in transgenic mice; however, limited data exist on the mechanism that dictates prostate-specific gene expression. Tissue-specific gene expression involves synergistic effects among transcription facto... | 10.1002/pros.21128 | 20,209,642 | D000727:Androgen-Binding Protein; D000728:Androgens; D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D047369:Chromatin Immunoprecipitation; D024202:Electrophoretic Mobility Shift Assay; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mic... | The Prostate | 2,010 | D000727:Androgen-Binding Protein; D000728:Androgens; C027519:probasin |
Antioxidants--clinical aspects. | Interest in nutrition and food consumption in advanced countries has become an important instrument of active care for maintaining the population's health. Basic orientation in food composition and in topical knowledge about the effectiveness of individual nutrients in the human organism form an indispensable part of n... | 15,141,970 | D000975:Antioxidants; D006801:Humans; D009747:Nutritional Physiological Phenomena; D014815:Vitamins | Central European journal of public health | 2,004 | D000975:Antioxidants; D014815:Vitamins | |
Bioengineered microbes for soil health restoration: present status and future. | According to the United Nations Environment Programme (UNEP), soil health is declining over the decades and it has an adverse impact on human health and food security. Hence, soil health restoration is a need of the hour. It is known that microorganisms play a vital role in remediation of soil pollutants like heavy met... | 10.1080/21655979.2021.2004645 | 34,775,906 | D001673:Biodegradation, Environmental; D005818:Genetic Engineering; D063245:Plant Development; D012987:Soil; D012988:Soil Microbiology; D015262:Xenobiotics | Bioengineered | 2,021 | D012987:Soil; D015262:Xenobiotics |
Probiotics Mediate Intestinal Microbiome and Microbiota-Derived Metabolites Regulating the Growth and Immunity of Rainbow Trout (Oncorhynchus mykiss). | Emerging evidence confirms using probiotics in promoting growth and immunity of farmed fish. However, the molecular mechanisms underlying the host-microbiome interactions mediated by probiotics are not fully understood. In this study, we used rainbow trout (Oncorhynchus mykiss) as a model to investigate the internal me... | 10.1128/spectrum.03980-22 | 36,916,965 | Microbiology spectrum | 2,023 | ||
Expression of a functional influenza viral cap-recognizing protein by using a bovine papilloma virus vector. | The gene for the influenza viral PB2 protein, which recognizes and binds the 5'-terminal cap 1 structures (m7GpppNm) on eukaryotic mRNAs, was inserted into a bovine papilloma virus vector under the control of a mouse metallothionein I (MT-I) promoter. After transfection of this vector into mouse NIH 3T3 cells, a cell l... | 10.1073/pnas.82.13.4326 | 2,989,815 | D000818:Animals; D001426:Bacterial Proteins; D052688:Bovine papillomavirus 1; D002460:Cell Line; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII; D015252:Deoxyribonucleases, Type II Site-Specific; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D009980:Influenza A vir... | Proceedings of the National Academy of Sciences of the United States of America | 1,985 | D001426:Bacterial Proteins; D012315:RNA Caps; D014764:Viral Proteins; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific |
Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece. | A seroepidemiological study was conducted on a representative sample of the northern Greek population (healthy individuals, age range=1 day to 80 years) to assess the prevalence of antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA). Antibody concentrations were significantly elevated with age (analy... | 10.1002/jcla.20025 | 15,103,688 | D018829:Adhesins, Bacterial; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001886:Bordetella pertussis; D002648:Child; D002675:Child, Preschool; D006115:Greece; D006388:Hemagglutinins; D006801:Humans; D0... | Journal of clinical laboratory analysis | 2,004 | D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006388:Hemagglutinins; D007074:Immunoglobulin G; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; D037342:Pertussis Toxin |
Effect of Mesopore Development on Butane Working Capacity of Biomass-Derived Activated Carbon for Automobile Canister. | Kenaf-derived activated carbons (AKC) were prepared by H3PO4 activation for automobile canisters. The microstructural properties of AKC were observed using Raman spectra and X-ray diffraction. The textural properties were studied using N2/77 K adsorption isotherms. Butane working capacity was determined according to th... | 10.3390/nano11030673 | 33,803,161 | Nanomaterials (Basel, Switzerland) | 2,021 | ||
White light emission from heterojunction diodes based on surface-oxidized porous Si nanowire arrays and amorphous In-Ga-Zn-O capping. | A novel heterojunction white light emitting diode (LED) structure based on an array of vertically aligned surface-passivated p-type porous Si nanowires (PSiNWs) with n-type amorphous In-Ga-Zn-O (a-IGZO) capping is introduced. PSiNWs were initially synthesized by electroless etching of p-type Si (100) wafers assisted by... | 10.1039/c3nr05328h | 24,556,906 | Nanoscale | 2,014 | ||
[Quadruplet pregnancies: management and obstetric and pediatric outcome]. | Multi-fetal gestations are associated with increased frequency of maternal, fetal and neonatal complications. Data on the prognosis of multi-fetal pregnancies are of particular importance when the option of selective termination is considered. The present study details the obstetric management, neonatal outcome, and fo... | 1,401,772 | D000032:Abortion, Therapeutic; D000328:Adult; D002585:Cesarean Section; D002985:Clinical Protocols; D006233:Disabled Persons; D005260:Female; D005602:France; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D009774:Ob... | Journal de gynecologie, obstetrique et biologie de la reproduction | 1,992 | ||
Progressive bone loss during long-term home total parenteral nutrition. | Metabolic bone disease occurs in patients receiving prolonged home total parenteral nutrition (HTPN). We studied bone-mass status in 10 patients (seven males, three females, age 19-66 years) who had been receiving HTPN for 0 to 67 months (mean 24 months), mostly for short-bowel syndrome. Four patients had spinal osteop... | 10.1177/0148607190014002139 | 2,112,620 | D000328:Adult; D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic; D005260:Female; D005500:Follow-Up Studies; D006701:Home Nursing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis; D010289:Parenteral Nutrition, Total; D012778:Short Bowel Syndrome | JPEN. Journal of parenteral and enteral nutrition | 1,990 | |
Inner ear changes with intracochlear gentamicin administration in Guinea pigs. | OBJECTIVES/HYPOTHESIS
Transtympanic administration of gentamicin is reported to be a useful treatment for vertigo in such conditions as Meniere's disease, and determining appropriate clinical dosage of gentamicin is difficult. The authors examined the relation between gentamicin dosages and inner ear function in guinea... | 10.1097/00005537-200404000-00018 | 15,064,626 | D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents; D003051:Cochlea; D003593:Cytoplasm; D004333:Drug Administration Routes; D016057:Evoked Potentials, Auditory, Brain Stem; D005839:Gentamicins; D006168:Guinea Pigs; D009760:Nystagmus, Physiologic; D009995:Osmosis; D012665:Semicircular Canals... | The Laryngoscope | 2,004 | D000900:Anti-Bacterial Agents; D005839:Gentamicins |
Clinical and laboratory findings of disseminated Mycobacterium avium complex infection (DMAC) in a pair matched case-control study. | A pair matched case/control study was conducted from January 1991 to 30 June 1992 in order to define clinical and laboratory findings associated with DMAC infection in AIDS patients. Since DMAC infection is usually associated with advanced immunodeficiency, and therefore also with other opportunistic illnesses, in addi... | 10.1590/s0036-46651999000500002 | 10,602,540 | D017088:AIDS-Related Opportunistic Infections; D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection; D013997:Time Fac... | Revista do Instituto de Medicina Tropical de Sao Paulo | 1,999 | |
An Eye on Movement Disorders. | Eye disorders spanning a range of ocular tissue are common in patients with movement disorders. Highlighting these ocular manifestations will benefit patients and may even aid in diagnosis. In this educational review we outline the anatomy and function of the ocular tissues with a focus on the tissues most affected in ... | 10.1002/mdc3.13317 | 34,765,682 | Movement disorders clinical practice | 2,021 | ||
Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines. | Amifostine is a first-line cytoprotective drug used to prevent radiotherapy-induced or chemotherapy-induced injuries. However, its mechanism of action is not well understood. In this study, freshly harvested bone marrow cells were treated with amifostine and analyzed with a series of mitochondrial indices. In vitro res... | 10.1007/978-1-4614-7411-1_27 | 23,852,495 | D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate; D004999:Amifostine; D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells; D016207:Cytokines; D008297:Male; D051379:Mice; D008928:Mitochondria; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species | Advances in experimental medicine and biology | 2,013 | D016207:Cytokines; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D004999:Amifostine |
Effect of 17 beta-estradiol on immunoglobulin secretion by human tonsillar lymphocytes in vitro. | Sex steroid hormones play a role in the complex network of immune responses but the mechanism of their action is still unclear. Effects of a wide range of doses of 17 beta-estradiol (E2: 0.2-100 ng/ml) on human tonsillar lymphocyte cultures were examined. B and T lymphocyte enriched preparations were stimulated with va... | 10.1016/0960-0760(94)90142-2 | 8,142,292 | D015703:Antigens, CD; D001402:B-Lymphocytes; D002478:Cells, Cultured; D004247:DNA; D004958:Estradiol; D006684:HLA-DR Antigens; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007376:Interleukin-2; D008214:Lymphocytes; D014066:Palatine Tonsil; D010835:Phytohemagglutinins; D0... | The Journal of steroid biochemistry and molecular biology | 1,994 | D015703:Antigens, CD; D006684:HLA-DR Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007376:Interleukin-2; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2; D004958:Estradiol; D004247:DNA |
Assembly and Function of the Bacillus anthracis S-Layer. | Bacillus anthracis, the anthrax agent, is a member of the Bacillus cereus sensu lato group, which includes invasive pathogens of mammals or insects as well as nonpathogenic environmental strains. The genes for anthrax pathogenesis are located on two large virulence plasmids. Similar virulence plasmids have been acquire... | 10.1146/annurev-micro-090816-093512 | 28,622,090 | D001408:Bacillus anthracis; D008562:Membrane Glycoproteins; D055503:Protein Multimerization | Annual review of microbiology | 2,017 | D008562:Membrane Glycoproteins; C055764:S-layer proteins |
Knowledge, treatment seeking and preventive practices in respect of malaria among patients with HIV attending Lagos University Teaching Hospital, Nigeria. | The synergistic interaction between Human Immunodeficiency virus (HIV) disease and malaria makes it mandatory for patients with HIV to respond appropriately in preventing and treating malaria. Such response will help to control the two diseases. This study assessed the knowledge of 495 patients attending the HIV clinic... | 10.4314/thrb.v13i4.63347 | 26,592,054 | D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008288:Malaria; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D011446:Prospective Studies; D012959:Socioeconomic Factors | Tanzania journal of health research | 2,011 | |
Comparison of Internal Standard Approaches for SRM Analysis of Alpha-Synuclein in Cerebrospinal Fluid. | Absolute protein quantification by selected reaction monitoring (SRM, also MRM) is an alternative to immunoassays, and the gold standard here is the addition of stable-isotope labeled (SIL) proteins (PSAQ). Cerebrospinal fluid (CSF) is the preferred source of biomarkers for neurological diseases, and recent improvement... | 10.1021/acs.jproteome.7b00660 | 29,183,121 | D006801:Humans; D007553:Isotope Labeling; D012015:Reference Standards; D015203:Reproducibility of Results; D051844:alpha-Synuclein | Journal of proteome research | 2,018 | D051844:alpha-Synuclein |
Ultrasound-guided delivery of thymidine kinase-nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy. | AIM
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Since no targeted therapy is available, gene-directed enzyme prodrug therapy (GDEPT) could be an attractive strategy for treating TNBC.
MATERIALS & METHODS
Polyethylene glycol (PEG)ylated-poly(lactic-co-glycolic acid)/polyethyleneimine n... | 10.2217/nnm-2017-0328 | 29,790,803 | D000818:Animals; D017209:Apoptosis; D001388:Aziridines; D045744:Cell Line, Tumor; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007773:Lactates; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles; D009601:Nitroreductases; D011092:Polyethylene Glycols; D013937:Thymidine Kinase; D014162:Transfection; D064... | Nanomedicine (London, England) | 2,018 | D001388:Aziridines; D007773:Lactates; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; C100099:tretazicar; D009601:Nitroreductases; D013937:Thymidine Kinase |
Omalizumab for chronic spontaneous urticaria in "complex" patients: data from real-life clinical practice. | INTRODUCTION
Omalizumab is a recombinant humanized anti-IgE monoclonal antibody, approved for patients affected by chronic spontaneous urticaria resistant to antihistamines. Although the clinical benefit of omalizumab has been established in several clinical trials, there are very little data about long-term treatment ... | 10.2147/DDDT.S214307 | 31,564,834 | D000328:Adult; D000368:Aged; D018926:Anti-Allergic Agents; D000080223:Chronic Urticaria; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007558:Italy; D008297:Male; D008875:Middle Aged; D000069444:Omalizumab; D011788:Quality of Life; D012189:Retrospective Studies | Drug design, development and therapy | 2,019 | D018926:Anti-Allergic Agents; D000069444:Omalizumab |
Hemoglobin oxygenation of venous-perfused forearm flaps. | To understand how venous flaps function we investigated whether blood flowing via the venous network reaches the capillaries of the skin. While measuring spectrophotometrically intracapillary hemoglobin oxygenation of fasciocutaneous forearm flaps in 12 patients, flap perfusion was changed by manipulating nutrient vess... | 10.1097/00000637-199812000-00011 | 9,869,139 | D000328:Adult; D000368:Aged; D002196:Capillaries; D002294:Carcinoma, Squamous Cell; D005260:Female; D005542:Forearm; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms; D010100:Oxygen; D012039:Regional Blood Flow; D012867:Skin; D013053:Spectrophotometry; D013524:Surgical Fla... | Annals of plastic surgery | 1,998 | D006454:Hemoglobins; D010100:Oxygen |
Study on the Heterogeneity of T-DM1 and the Analysis of the Unconjugated Linker Structure under a Stable Conjugation Process. | Trastuzumab emtansine (T-DM1) is a target-specific anticancer antibody-drug conjugate (ADC). In the present study, critical quality attributes for different manufactured products, such as the drug to antibody ratio (DAR), conjugation site, and site conjugation ratio, are similar, which is contrary to the traditional vi... | 10.1021/acsomega.9b00430 | 31,459,971 | ACS omega | 2,019 | ||
Ethics and practice in organ transplantation in patients infected with human immunodeficiency virus. | In sum, much more needs to be known about the issue of transplantation in HIV-infected patients before the current state of extremely limited access to transplantation for these patients can be medically and ethically justified. Approaches to remedy this situation may include well-designed outcome studies; revision of ... | 11,873,755 | D000075202:Contraindications; D003422:Critical Care; D003657:Decision Making; D004992:Ethics, Medical; D004993:Ethics, Nursing; D015658:HIV Infections; D017048:Health Care Costs; D015276:Health Care Rationing; D006801:Humans; D017053:Infection Control; D020380:Needs Assessment; D024802:Nurse's Role; D016377:Organ Trans... | Critical care nurse | 2,000 | ||
Improving Mental Health and Well-Being through Informal Mindfulness Practices: An Intervention Study. | BACKGROUND
Mindfulness-based programs have been shown to be effective in reducing stress, anxiety, and depression symptoms, and enhancing well-being. However, it remains unclear whether longer formal mindfulness practices are necessary to obtain such results. We therefore aimed to assess the effectiveness of a program ... | 10.1111/aphw.12216 | 32,851,775 | D001007:Anxiety; D003863:Depression; D006801:Humans; D008603:Mental Health; D064866:Mindfulness; D013315:Stress, Psychological; D011795:Surveys and Questionnaires | Applied psychology. Health and well-being | 2,021 | |
Percutaneous sclerotherapy with OK-432 for lymphocele after pelvic or para-aortic lymphadenectomy: preliminary results. | BACKGROUND
Lymphoceles can result from disruption of lymphatic vessels after surgical procedures in areas with extensive lymphatic networks. Percutaneous catheter drainage with sclerotherapy can be performed for the treatment of lymphoceles. OK-432 has been used to treat benign cysts, such as lymphangioma and ranula. T... | 10.1186/s42155-022-00332-z | 36,264,442 | CVIR endovascular | 2,022 | ||
New hexamethine-hemicyanine dyes for the development of integrated optochemical sensors. | New far-visible absorbing anilino-cyanine dyes have been synthesised for future application as chromoionophores in integrated waveguide absorbance optodes based on bulk optodes. The effect of the heterocycle, of the substitution of the heterocyclic nitrogen and of the type of heptamethine central ring on the pKa values... | 10.1007/s00216-006-1068-z | 17,226,002 | D000814:Aniline Compounds; D002232:Carbocyanines; D004396:Coloring Agents; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010777:Photochemistry; D012996:Solutions | Analytical and bioanalytical chemistry | 2,007 | D000814:Aniline Compounds; D002232:Carbocyanines; D004396:Coloring Agents; D012996:Solutions; C023650:aniline |
Non-arteritic anterior ischemic optic neuropathy as first manifestation of antiphospholipid syndrome in a young patient. | CASE REPORT
We report the case of a young patient with unilateral anterior ischemic optic neuropathy, with no known cardiovascular risk factors and visual acuity preserved with positive anticardiolipin antibodies as a unique find.
DISCUSSION
Non-arteritic anterior ischemic optic neuropathy in the context of antiphosp... | 24,365,401 | D016736:Antiphospholipid Syndrome; D006801:Humans; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic | Archivos de la Sociedad Espanola de Oftalmologia | 2,014 | ||
Non-radioisotopic detection of human xenogeneic DNA in a mouse transplantation model. | Xenogeneic mouse models are widely used for the study of human tumor growth and metastasis. To date, few methods have been developed to track and quantitate the colonization of mouse organs with transplanted human cells. In this paper, a family of nonradioisotopic DNA oligonucleotide probes that are complementary to se... | 10.1006/mcpr.1996.0019 | 8,737,398 | D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D003110:Colonic Neoplasms; D004247:DNA; D006801:Humans; D017710:Lymphocyte Transfusion; D051379:Mice; D016513:Mice, SCID; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D012091:Repetitive Sequences, Nucleic Acid; D0... | Molecular and cellular probes | 1,996 | D015345:Oligonucleotide Probes; D004247:DNA |
Homing in on the homeless: assessing the physical health of homeless adults in Los Angeles County using an original method to obtain physical examination data in a survey. | OBJECTIVE
Public policy that decreases the finding for social services may combine with the ascendancy of corporate managed care to increase the health care deficit. Assessing the health impact of these policy changes on various populations is a fundamental challenge for health services research. Disadvantaged populati... | 8,943,989 | D000328:Adult; D015982:Bias; D005260:Female; D006305:Health Status Indicators; D006703:Ill-Housed Persons; D006801:Humans; D015141:Los Angeles; D008297:Male; D015588:Observer Variation; D010808:Physical Examination; D015995:Prevalence; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires | Health services research | 1,996 | ||
Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim50. | The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. Tim50 is a major receptor for transporting the precursor protein across the mitochondrial inner membrane in TIM23 complex. However, the interaction of divalent metal... | 23,098,911 | D002118:Calcium; D002413:Cations, Divalent; D006801:Humans; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D017434:Protein Structure, Tertiary | Biochemical and biophysical research communications | 2,012 | D002413:Cations, Divalent; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C438387:TIMM23 protein, human; C509348:TIMM50 protein, human; D002118:Calcium | |
[Long-term result of low anterior resection with stapling devices for rectal cancer]. | BACKGROUND & OBJECTIVE
Currently, to preserve the anal function and improve the patients' quality of life, low anterior resection has become the preferred option in curative rectal cancer surgery. As the use of stapling instruments provides more reliable anastomoses in low anterior resection for rectal cancer, it enlar... | 15,566,668 | D000230:Adenocarcinoma; D002288:Adenocarcinoma, Mucinous; D000231:Adenocarcinoma, Papillary; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms; D016015:Logistic Models; D008297:Mal... | Ai zheng = Aizheng = Chinese journal of cancer | 2,004 | ||
[Quantitative Analysis of Heavy Metals in Water with LIBS Based on Signal-to-Background Ratio]. | There are many influence factors in the precision and accuracy of the quantitative analysis with LIBS technology. According to approximately the same characteristics trend of background spectrum and characteristic spectrum along with the change of temperature through in-depth analysis, signal-to-background ratio (S/B) ... | 26,717,770 | Guang pu xue yu guang pu fen xi = Guang pu | 2,015 | |||
The Combination of Laser Therapy and Metal Nanoparticles in Cancer Treatment Originated From Epithelial Tissues: A Literature Review. | Several methods have been employed for cancer treatment including surgery, chemotherapy and radiation therapy. Today, recent advances in medical science and development of new technologies, have led to the introduction of new methods such as hormone therapy, Photodynamic therapy (PDT), treatments using nanoparticles an... | 10.15171/jlms.2016.13 | 27,330,701 | Journal of lasers in medical sciences | 2,016 | ||
Plasma homocysteine levels in 10 patients with polycythemia. | Polycythemia and hyperhomocysteinemia are risk factors for thrombosis. Since red blood cells actively metabolize methionine to homocysteine, we investigated whether or not patients with polycythemia have increased plasma levels of homocysteine, which might contribute to their increased thrombotic risk. In ten patients ... | 9,234,587 | D000328:Adult; D000368:Aged; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006710:Homocysteine; D006801:Humans; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D011086:Polycythemia; D011087:Polycythemia Vera; D012307:Risk Factors; D013927:Thrombosis | Haematologica | 1,997 | D006710:Homocysteine | |
Zinc protection against cadmium-induced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells. | Adult female rats were treated subcutaneously (s.c.) with zinc chloride (ZnCl2, 10 or 20 mg kg-1 body weight, bw) four times during two ovarian cycles. The third injection was accompanied by cadmium chloride (CdCl2) administration sc (2.5, 5 and 10 mg kg-1 bw). The fourth zinc (Zn) treatment was followed by mating. ZnC... | 10.1023/a:1018362603065 | 9,002,180 | D000818:Animals; D002104:Cadmium; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone; D006107:Granulosa Cells; D007247:Infertility, Female; D007986:Luteinizing Hormone; D008297:Male; D011247:Pregnancy; D011374:Progesterone; D051381:Rats; D015032:Zinc | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine | 1,997 | D002104:Cadmium; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015032:Zinc |
Neural encoding of the speech envelope by children with developmental dyslexia. | Developmental dyslexia is consistently associated with difficulties in processing phonology (linguistic sound structure) across languages. One view is that dyslexia is characterised by a cognitive impairment in the "phonological representation" of word forms, which arises long before the child presents with a reading p... | 27,433,986 | D000293:Adolescent; D002648:Child; D003463:Cues; D004410:Dyslexia; D004569:Electroencephalography; D006801:Humans; D009474:Neurons; D010700:Phonetics; D011932:Reading; D012660:Semantics; D013060:Speech; D013067:Speech Perception | Brain and language | 2,016 | ||
Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects. | The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology and tropical medicine. Eco-friendly vector control programs are crucial to fight, ... | 10.1007/s11356-017-9752-4 | 28,755,145 | D000818:Animals; D003715:Dengue; D006801:Humans; D007303:Insect Vectors; D008288:Malaria; D009032:Mosquito Control; D000074823:One Health; D000071244:Zika Virus; D000071243:Zika Virus Infection | Environmental science and pollution research international | 2,018 | |
Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: clinical validation. | BACKGROUND
There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping (FT) that uses evolutionary algorithms (EAs) and... | 10.1186/s40035-018-0124-x | 30,147,869 | Translational neurodegeneration | 2,018 | ||
Cognition and aided speech recognition in noise: specific role for cognitive factors following nine-week experience with adjusted compression settings in hearing aids. | The working memory model for Ease of Language Understanding (ELU) proposes that language understanding under taxing conditions is related to explicit cognitive capacity. We refer to this as the mismatch hypothesis, since phonological representations based on the processing of speech under established conditions may not... | 10.1111/j.1467-9450.2009.00745.x | 19,778,388 | D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003071:Cognition; D032882:Comprehension; D005260:Female; D006310:Hearing Aids; D034381:Hearing Loss; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D009... | Scandinavian journal of psychology | 2,009 | |
Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines. | The knockdown of genes that are over-expressed in cancer, and function in tumor onset and/or progression, is an attractive tool to impair the growth of tumor cells. Synthetic nucleic acids such as antisense oligodeoxynucleotides (AS-ODNs) or small-interfering RNAs (siRNAs) were applied against different tumor-associate... | 10.1007/978-1-60327-070-0_2 | 18,369,813 | D002452:Cell Count; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D015536:Down-Regulation; D004354:Drug Screening Assays, Antitumor; D004794:Enzyme Repression; D005453:Fluorescence; D006801:Humans; D008967:Molecular Biology; D016376:Oligonucleotides, Antisense; D034741... | Methods in molecular biology (Clifton, N.J.) | 2,007 | D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering; C509186:TERT protein, human; D019098:Telomerase |
Association Between Active Commuting and Incident Cardiovascular Diseases in Chinese: A Prospective Cohort Study. | Background Active commuting is related to a higher level of physical activity but more exposure to ambient air pollutants. With the rather serious air pollution in urban China, we aimed to examine the association between active commuting and risk of incident cardiovascular disease in the Chinese population. Methods and... | 10.1161/JAHA.119.012556 | 31,576,770 | D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases; D002681:China; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D057566:Self Report; D014186:Transportation; D014505... | Journal of the American Heart Association | 2,019 | |
The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. | The repair of DNA double-strand breaks (DSBs) is essential to maintain genomic integrity. In higher eukaryotes, DNA DSBs are predominantly repaired by non-homologous end joining (NHEJ), but DNA ends can also be joined by an alternative error-prone mechanism termed microhomology-mediated end joining (MMEJ). In MMEJ, the... | 10.1093/nar/gkp905 | 19,892,829 | D000818:Animals; D034961:Antigens, Nuclear; D002352:Carrier Proteins; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D045643:DNA Repair Enzymes; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D000072200:Ku Autoantigen; D000076228:MRE11 Homologue Protein; D010063:Ovum; D011995:Recombinatio... | Nucleic acids research | 2,010 | D034961:Antigens, Nuclear; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C510917:Mre11 protein, Xenopus; C511600:NBN protein, Xenopus; C542167:Rad50 protein, Xenopus; D025521:Tumor Suppressor Proteins; D029867:Xenopus Proteins; D051747:DNA-Activated Protein Kinase; D000076228:MRE11 Homologue Protein; D0000722... |
Improved Anti-Prion Nucleic Acid Aptamers by Incorporation of Chemical Modifications. | Nucleic acid aptamers are innovative and promising candidates to block the hallmark event in the prion diseases, that is the conversion of prion protein (PrP) into an abnormal form; however, they need chemical modifications for effective therapeutic activity. This communication reports on the development and biophysica... | 10.1089/nat.2020.0899 | 32,991,255 | D000818:Animals; D052157:Aptamers, Nucleotide; D001665:Binding Sites; D006801:Humans; D009696:Nucleic Acids; D017096:Prion Diseases; D011328:Prions; D011485:Protein Binding; D052156:SELEX Aptamer Technique | Nucleic acid therapeutics | 2,020 | D052157:Aptamers, Nucleotide; D009696:Nucleic Acids; D011328:Prions |
Challenges of Dental Hygienists in a Multidisciplinary Team Approach During Palliative Care for Patients With Advanced Cancer: A Nationwide Study. | PURPOSE
Palliative care is constructed by various kinds of professionals. This study aimed to identify the challenges that dental hygienists (DHs) encountered when working with other professionals in a multidisciplinary team approach in palliative care for advanced cancer patients.
METHODS
We conducted the following ... | 10.1177/1049909120960708 | 32,969,232 | D003430:Cross-Sectional Studies; D003756:Dental Hygienists; D006801:Humans; D009369:Neoplasms; D010166:Palliative Care; D010348:Patient Care Team; D011795:Surveys and Questionnaires | The American journal of hospice & palliative care | 2,021 | |
Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. | The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin-Sca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes Lin-CD122+CD49a+ progenitors t... | 10.1126/science.aba4177 | 33,766,856 | D000818:Animals; D006411:Hematopoiesis, Extramedullary; D007113:Immunity, Innate; D007371:Interferon-gamma; D007694:Killer Cells, Natural; D008099:Liver; D008214:Lymphocytes; D054503:Lymphoid Progenitor Cells; D038041:Lymphopoiesis; D051379:Mice; D017471:Receptors, Interferon; D015398:Signal Transduction; D020825:T-Box... | Science (New York, N.Y.) | 2,021 | C000611649:IFNG protein, mouse; D017471:Receptors, Interferon; D020825:T-Box Domain Proteins; C406820:T-box transcription factor TBX21; D007371:Interferon-gamma |
Hg Doping Induced Reduction in Structural Disorder Enhances the Thermoelectric Performance in AgSbTe2. | Defect engineering, achieved by precise tuning of the atomic disorder within crystalline solids, forms a cornerstone of structural chemistry. This nuanced approach holds the potential to significantly augment thermoelectric performance by synergistically manipulating the interplay between the charge carrier and lattice... | 10.1021/jacs.3c09643 | 37,942,795 | Journal of the American Chemical Society | 2,023 | ||
Prion protein-dependent regulation of p53-MDM2 crosstalk during endoplasmic reticulum stress and doxorubicin treatments might be essential for cell fate in human breast cancer cell line, MCF-7. | In this study, we investigated the effect of doxorubicin and tunicamycin treatment alone or in combination on MDM-, Cul9-and prion protein (PrP)-mediated subcellular regulation of p53 in the context of apoptosis and autophagy. MTT analysis was performed to determine the cytotoxic effect of the agents. Apoptosis was mon... | 10.1016/j.yexcr.2023.113656 | 37,245,583 | D006801:Humans; D005260:Female; D000072002:Prion Proteins; D016159:Tumor Suppressor Protein p53; D014415:Tunicamycin; D061986:MCF-7 Cells; D001943:Breast Neoplasms; D004317:Doxorubicin; D059865:Endoplasmic Reticulum Stress; D011328:Prions; D051736:Proto-Oncogene Proteins c-mdm2; D017209:Apoptosis; D045744:Cell Line, Tu... | Experimental cell research | 2,023 | D000072002:Prion Proteins; D016159:Tumor Suppressor Protein p53; D014415:Tunicamycin; D004317:Doxorubicin; D011328:Prions; D051736:Proto-Oncogene Proteins c-mdm2; C497206:MDM2 protein, human |
Action Control of Colorectal Cancer Screening Participation with fecal immunochemical test (FIT). | BACKGROUND
Most of the individuals concerned by colorectal cancer screening recognize the importance of screening participation. However, the screening rates for this cancer remain low in most countries, including France. Based on the action control framework, the present study aimed to (i) explore the distribution of ... | 10.1007/s12529-021-09976-y | 33,786,774 | D001290:Attitude; D015179:Colorectal Neoplasms; D055088:Early Detection of Cancer; D006801:Humans; D033182:Intention; D011582:Psychological Theory; D011795:Surveys and Questionnaires | International journal of behavioral medicine | 2,022 | |
Glycine tomentella Hayata inhibits IL-1β and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells. | BACKGROUND
To assess the effects of Glycine tomentella Hayata (GTH), a traditional herbal medicine for treatment of rheumatic diseases on the expression of the proinflammatory cytokines and on the clearance of apoptotic cells by macrophages.
METHODS
RAW264.7 cells were cultured with lipopolysaccharide (LPS) in the pr... | 10.1186/1423-0127-17-83 | 21,054,849 | D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D019204:GTP-Binding Proteins; D005998:Glycine; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D008264:Macrophages; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D052247:Nitric Oxide Sy... | Journal of biomedical science | 2,010 | D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D052247:Nitric Oxide Synthase Type II; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D020780:Mat... |
Investigation of the relationship between convenient visits and doctors' fatigue using burnout and work engagement scales. | OBJECTIVES
Fatigue caused by high workload is often responsible for the high attrition among doctors, and has contributed to a disruption in community medicine. In order to address this problem, institutional mechanisms at the hospital level are required. Previous studies have shown that systemic measures at the hospit... | 10.11236/jph.62.9_556 | 26,608,045 | D000328:Adult; D001071:Appointments and Schedules; D002055:Burnout, Professional; D005260:Female; D006801:Humans; D008297:Male; D014940:Work Schedule Tolerance | [Nihon koshu eisei zasshi] Japanese journal of public health | 2,015 | |
[Effect of P53 Expression on Prognosis of Patients with Double Expressor Lymphoma]. | OBJECTIVE
To investigate the effect of P53 expression on prognosis of patients with double expressor lymphoma(DEL) and the interaction between the expression of MYC, BCL2 and P53 in diffuse large B-cell lymphoma(DLBCL).
METHODS
Eighty-eight patients with newly diagnosed DLBCL from 1st September 2012 to 31th May 2018 ... | 10.19746/j.cnki.issn.1009-2137.2019.05.023 | 31,607,305 | D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53 | Zhongguo shi yan xue ye xue za zhi | 2,019 | D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53 |
A novel SPINK5 donor splice site variant in a child with Netherton syndrome. | BACKGROUND
Netherton syndrome (NS) is a genodermatosis caused by loss-of-function mutations in SPINK5, resulting in aberrant LEKTI expression.
METHOD
Next-generation sequencing of SPINK5 (NM_001127698.1) was carried out and functional studies were performed by immunofluorescence microscopy of a lesional skin biopsy u... | 10.1002/mgg3.1611 | 33,534,181 | D002675:Child, Preschool; D006801:Humans; D008297:Male; D009154:Mutation; D056770:Netherton Syndrome; D010641:Phenotype; D012326:RNA Splicing; D000074163:Serine Peptidase Inhibitor Kazal-Type 5 | Molecular genetics & genomic medicine | 2,021 | C120650:SPINK5 protein, human; D000074163:Serine Peptidase Inhibitor Kazal-Type 5 |
Perceptual evaluation of alaryngeal speech. | The aim of this study was to compare the self-assessed vocal handicap of laryngectomees treated with three different communication methods: tracheoesophageal speech, esophageal speech and electrolarynx. Forty-eight patients, 40 males and 8 females, who had undergone total laryngectomy for laryngeal carcinoma were enrol... | 23,397,768 | D001307:Auditory Perception; D005260:Female; D006801:Humans; D007825:Laryngectomy; D007830:Larynx; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires | Collegium antropologicum | 2,012 | ||
[Anesthetic procedures in endoscopic interventions of the respiratory system]. | Choice and application of anaesthesia in patients undergoing endoscopies of the airways have to take into consideration several specific aspects, starting with preanaesthetic investigation and premedication. On principle local anaesthesia may be administered as well as general anaesthesia or a combination of both. Usin... | 3,087,071 | D000768:Anesthesia, General; D000772:Anesthesia, Local; D000779:Anesthetics, Local; D001999:Bronchoscopy; D002245:Carbon Dioxide; D006439:Hemodynamics; D006801:Humans; D010100:Oxygen; D011229:Preanesthetic Medication; D012018:Reflex; D012140:Respiratory Tract Diseases | Zeitschrift fur Erkrankungen der Atmungsorgane | 1,986 | D000779:Anesthetics, Local; D002245:Carbon Dioxide; D010100:Oxygen | |
Measurement and FEM/BEM simulation of transverse effects in SAW resonators on lithium tantalate. | It is well known that transverse effects contribute significantly to the loss of SAW resonators on lithium tantalate. In particular, for frequencies above resonance, the surface wave is not guided inside the transducer and radiates into the busbars. In addition, because bulk modes can also be excited, scalar models are... | 10.1109/TUFFC.2013.6644743 | 24,158,295 | IEEE transactions on ultrasonics, ferroelectrics, and frequency control | 2,013 | ||
Hematological changes in human lymphotropic-T virus type 1 carriers. | The human T-lymphotropic virus type 1 (HTLV-1), isolated in 1980, causes T-cell leukemia/lymphoma in adulthood, a type of lymphoproliferative disease, and chronic HTLV-1-associated myelopathy, a disease that causes paralysis of the lower limbs, which occur in about 5% of cases in this viral infection. This study aimed ... | 10.3389/fmicb.2022.1003047 | 36,353,451 | Frontiers in microbiology | 2,022 | ||
Mapping and direct valuation: do they give equivalent EQ-5D-5L index scores? | OBJECTIVE
Utility values of health states defined by health-related quality of life instruments can be derived from either direct valuation ('valuation-derived') or mapping ('mapping-derived'). This study aimed to compare the utility-based EQ-5D-5L index scores derived from the two approaches as a means to validating t... | 10.1186/s12955-015-0361-y | 26,438,167 | D000328:Adult; D000368:Aged; D001943:Breast Neoplasms; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011594:Psychometrics; D011788:Quality of Life; D012044:Regression Analysis; D015203:Reproducibility of Results; D011795:Surveys and Questionn... | Health and quality of life outcomes | 2,015 | |
DMSA renal scans in adults with acute pyelonephritis. | The 99mTc-DMSA scan is accepted as the most sensitive imaging modality for detecting areas of renal parenchymal scarring. More recently the DMSA scan has also been shown to be of value in imaging areas of renal parenchymal involvement in both children and adults with acute pyelonephritis. We assessed the acute DMSA sca... | 8,869,786 | D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011704:Pyelonephritis; D011877:Radionuclide Imaging; D012008:Recurrence; D0... | Clinical nephrology | 1,996 | D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer | |
Polymorphism of the prion protein in mammals: a phylogenetic approach. | PrP, the principal factor modulating resistance/susceptibility to transmissible spongiform encephalopathies, is a well conserved protein bearing strong phylogenetic information, in spite of its relatively short sequence. The construction of the PrP tree allows inferring the probable ancestral sequence for Bovidae where... | 10.2174/187221509787236156 | 19,149,740 | D019943:Amino Acid Substitution; D000818:Animals; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D008322:Mammals; D008954:Models, Biological; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011328:Prions; D013045:Species Specificity | Recent patents on DNA & gene sequences | 2,009 | D011328:Prions |
The family context of autism spectrum disorders: influence on the behavioral phenotype and quality of life. | This article reports the findings from a longitudinal program of research examining the bidirectional influences of the family environment on the behavioral phenotype of autism, and describes a newly developed family psychoeducation program, titled Transitioning Together, designed to reduce family stress, address behav... | 24,231,173 | D000293:Adolescent; D002648:Child; D002659:Child Development Disorders, Pervasive; D019260:Expressed Emotion; D005192:Family Health; D005195:Family Relations; D005196:Family Therapy; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D010641:Phenotype; D015397:Program Evaluation; D011788:Quality of Life; D0... | Child and adolescent psychiatric clinics of North America | 2,014 | ||
Immunohistowax processing, a new fixation and embedding method for light microscopy, which preserves antigen immunoreactivity and morphological structures: visualisation of dendritic cells in peripheral organs. | AIMS
To describe a new fixation and embedding method for tissue samples, immunohistowax processing, which preserves both morphology and antigen immunoreactivity, and to use this technique to investigate the role of dendritic cells in the immune response in peripheral tissues.
METHODS
This technique was used to stain ... | 10.1136/jcp.53.7.518 | 10,961,175 | D000818:Animals; D003713:Dendritic Cells; D004926:Escherichia coli; D005260:Female; D007111:Immunity, Cellular; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013194:Staining and Labeling; D013601:T-Lymphocytes; D016707:Tissue Fixation | Journal of clinical pathology | 2,000 | |
A simulation model for colorectal cancer screening: potential of stool tests with various performance characteristics compared with screening colonoscopy. | OBJECTIVE
Many new stool tests intended to detect neoplastic cells or cell products are developed at present for colorectal cancer (CRC) screening. The aim of this study was to simulate a population-based screening setting to assess and compare the potential for early detection and prevention of CRC of screening based ... | 10.1158/1055-9965.EPI-04-0411 | 15,734,968 | D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008297:Male; D008390:Markov Chains; D008403:Mass Screening; D008875:Middle Aged; D009780:Occult Blood; D012680:Sensitivity and Specificity | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 2,005 | |
There are no caterpillars in a wicked forest. | Species trees represent the historical divergences of populations or species, while gene trees trace the ancestry of individual gene copies sampled within those populations. In cases involving rapid speciation, gene trees with topologies that differ from that of the species tree can be most probable under the standard ... | 26,365,816 | D049810:Genetic Speciation; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree | Theoretical population biology | 2,015 | ||
α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. | In the brain, AMPA-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain-containing 6 (ABHD6), a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecular complexes, but its... | 10.1073/pnas.1524589113 | 27,114,538 | D000200:Action Potentials; D000818:Animals; D002462:Cell Membrane; D002478:Cells, Cultured; D057809:HEK293 Cells; D006624:Hippocampus; D006801:Humans; D051379:Mice; D008994:Monoacylglycerol Lipases; D009474:Neurons; D000072417:Protein Domains; D018091:Receptors, AMPA; D009435:Synaptic Transmission | Proceedings of the National Academy of Sciences of the United States of America | 2,016 | D018091:Receptors, AMPA; C527261:ABHD6 protein, mouse; D008994:Monoacylglycerol Lipases |
Qubit leakage suppression by ultrafast composite pulses. | The leakage suppression problem is considered for a three-level ladder-type quantum system, in which the first two levels are the qubit system and the third is the leakage state weakly coupled to the qubit system. We show that two (three) phase- and amplitude-controlled pulses are sufficient for arbitrary qubit control... | 10.1364/OE.27.003944 | 30,876,018 | Optics express | 2,019 | ||
Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. | Wild-type and palmitoylation defective mutants of the murine G protein G11alpha were transfected into HEK293 cells. Wild-type G11alpha was membrane associated, Cys9Ser Cys10Ser G11alpha was present in the soluble fraction whilst both Cys9Ser G11alpha and Cys10Ser G11alpha were distributed between the fractions. Express... | 10.1016/s0014-5793(97)00300-1 | 9,175,863 | D000818:Animals; D002460:Cell Line; D004789:Enzyme Activation; D019204:GTP-Binding Proteins; D006801:Humans; D051379:Mice; D009154:Mutation; D010169:Palmitic Acids; D010727:Phosphoric Diester Hydrolases; D051381:Rats; D018025:Receptors, Thyrotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D014162:Trans... | FEBS letters | 1,997 | D010169:Palmitic Acids; D018025:Receptors, Thyrotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D010727:Phosphoric Diester Hydrolases; C021491:glycerophosphoinositol glycerophosphodiesterase; D019204:GTP-Binding Proteins |
miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway. | BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, plays a role in the organization of super-enhancers and transcriptional activation of oncogenes in cancer and is recognized as a promising target for cancer therapy. microRNAs (miRNAs), endogenous small noncoding RNAs, cause mRNA degradat... | 10.1016/j.ymthe.2020.04.001 | 32,320,642 | D017209:Apoptosis; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D004260:DNA Repair; D030541:Databases, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015723:Gene Library; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms; D034622:RNA In... | Molecular therapy : the journal of the American Society of Gene Therapy | 2,020 | C441289:BRD4 protein, human; D018797:Cell Cycle Proteins; C000589719:MIRN1293 microRNA, human; D035683:MicroRNAs; D014157:Transcription Factors |
A rare cause of scalp swelling in infancy: delayed subaponeurotic fluid collections in five cases. | Subaponeurotic (subgaleal) fluid collection (DSFC) is a rare clinical entity of unknown etiology. We aimed to present our series of infants who were diagnosed with DSCF at Ankara University Children's Hospital. We retrospectively reviewed clinical findings, imaging studies, laboratory tests, management, and clinical co... | 10.1007/s00381-018-04040-9 | 30,613,856 | D000072700:Conservative Treatment; D004487:Edema; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012535:Scalp | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | 2,019 | |
Carbohydrate metabolism. Evaluation in women with de novo hypertension in late pregnancy. | OBJECTIVE
To evaluate carbohydrate metabolism in both diabetic and nondiabetic women with de novo hypertension in late pregnancy.
STUDY DESIGN
Sixty-nine nondiabetic pregnant women were studied: 33 with gestational hypertension, 15 with preeclampsia and 21 normotensives in the control group. Eight women with gestatio... | 9,284,010 | D000328:Adult; D001786:Blood Glucose; D016640:Diabetes, Gestational; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension; D007328:Insulin; D011225:Pre-Eclampsia; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011446:Prospective Studies | The Journal of reproductive medicine | 1,997 | D001786:Blood Glucose; D007328:Insulin | |
Serotonin in the gastrointestinal tract. | PURPOSE OF REVIEW
To assess the role of serotonin and its control in the manifestations and treatment of lower functional gastrointestinal disorders.
RECENT FINDINGS
Recent literature has explored several novel concepts in the association of serotonin and symptoms, alterations in tissue levels of serotonin and its re... | 10.1097/med.0b013e32831e9c8e | 19,115,522 | D003672:Defecation; D004435:Eating; D005767:Gastrointestinal Diseases; D041981:Gastrointestinal Tract; D006801:Humans; D006897:Hydroxyindoleacetic Acid; D043183:Irritable Bowel Syndrome; D019964:Mood Disorders; D011985:Receptors, Serotonin; D012701:Serotonin; D018490:Serotonin Agents | Current opinion in endocrinology, diabetes, and obesity | 2,009 | D011985:Receptors, Serotonin; D018490:Serotonin Agents; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid |
A neonatal blueprint for cardiac regeneration. | Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have establ... | 25,108,892 | D000818:Animals; D000831:Animals, Newborn; D049109:Cell Proliferation; D006321:Heart; D006801:Humans; D051379:Mice; D009206:Myocardium; D012038:Regeneration | Stem cell research | 2,014 | ||
Practices of Initiation of Vasoactive Drugs in Relation to Resuscitation Fluids in Children with Septic Shock: A Prospective Observational Study. | Background: The role of vasoactive medications in septic shock is well-defined, but the appropriate time of initiation of these medications in reference to fluid boluses is not clear. We planned to study prospectively the practices and outcome of initiation of vasoactive infusions with respect to resuscitation fluids b... | 10.5005/jp-journals-10071-23954 | 34,733,036 | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | 2,021 | ||
Prevalence and experiences of Wisconsin women turned away from Catholic settings without receiving reproductive care. | OBJECTIVE
To estimate prevalence of being turned away from a Catholic healthcare setting without receiving desired reproductive care among Wisconsin women and to document firsthand accounts of these experiences.
STUDY DESIGN
Between October 2019 and April 2020, we fielded a two-stage survey to Wisconsin women aged 18... | 10.1016/j.contraception.2021.05.007 | 34,023,379 | D002410:Catholicism; D005260:Female; D016519:Hospitals, Religious; D006801:Humans; D015995:Prevalence; D013246:Sterilization, Tubal; D014922:Wisconsin | Contraception | 2,021 | |
Tumor necrosis factor-alpha effects on rat gastric enterochromaffin-like cells. | Gastric enterochromaffin-like (ECL) cells are histamine-producing cells in the gastric epithelium which are responsible for the peripheral regulation of acid secretion. The gastric mucosa is frequently infected with Helicobacter pylori, leading to increased levels of the pro-inflammatory cytokine tumor necrosis factor-... | 10.1159/000057710 | 12,021,482 | D000818:Animals; D017209:Apoptosis; D015153:Blotting, Western; D024202:Electrophoretic Mobility Shift Assay; D019861:Enterochromaffin-like Cells; D005753:Gastric Mucosa; D016328:NF-kappa B; D009569:Nitric Oxide; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha | Digestion | 2,002 | D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide |
Fabrication and Deposition of Copper and Copper Oxide Nanoparticles by Laser Ablation in Open Air. | The proximity of the "post-antibiotic era", where infections and minor injuries could be a cause of death, there are urges to seek an alternative for the cure of infectious diseases. Copper nanoparticles and their huge potential as a bactericidal agent could be a solution. In this work, Cu and Cu oxide nanoparticles we... | 10.3390/nano10020300 | 32,050,620 | Nanomaterials (Basel, Switzerland) | 2,020 | ||
The effect of hypoxia and catecholamines on regional expression of heat-shock protein-72 mRNA in neonatal piglet brain. | The present study has shown that hypoxia leads to expression of heat-shock protein in the brain of newborn piglets and this process is almost completely abolished by depletion of catecholamines prior to the hypoxic episode. The piglets were anesthetized and mechanically ventilated. One hour of hypoxia was generated by ... | 10.1016/0006-8993(96)00363-0 | 8,842,392 | D000818:Animals; D000831:Animals, Newborn; D001921:Brain; D002540:Cerebral Cortex; D004791:Enzyme Inhibitors; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D002534:Hypoxia, Brain; D017403:In Situ Hybridization; D008781:Methyltyrosines; D010100:Oxygen; D012333:RNA, Messenger; D012016:Reference Values; ... | Brain research | 1,996 | D004791:Enzyme Inhibitors; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D008781:Methyltyrosines; D012333:RNA, Messenger; D019805:alpha-Methyltyrosine; D014446:Tyrosine 3-Monooxygenase; D010100:Oxygen |
The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update. | The COVID-19 pandemic led to widespread use of telemedicine and highlighted its importance in improving access to sleep care and advocating for sleep health. This update incorporates the lessons learned from such widespread utilization of telehealth to build on the American Academy of Sleep Medicine's 2015 position pap... | 10.5664/jcsm.9194 | 33,599,202 | D000047:Academies and Institutes; D000086382:COVID-19; D006801:Humans; D056508:Sleep Medicine Specialty; D012893:Sleep Wake Disorders; D017216:Telemedicine; D014481:United States | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2,021 | |
[The bleeding ulcer of the duodenum: the procedure in unreliable hemostasis]. | The treatment of patients with bleeding duodenal ulcers is still one of the most complicated and discussable problems in surgery. The aim of this study was an attempt to predict the relapse of bleeding from ulcer of the duodenum on the basis of the experience in the treatment of 539 patients with this disease, 101 of w... | 10,410,511 | D000328:Adult; D004381:Duodenal Ulcer; D004630:Emergencies; D006489:Hemostatic Techniques; D006801:Humans; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors | Khirurgiia | 1,999 | ||
Oxidative stress response signaling pathways in trabecular meshwork cells and their effects on cell viability. | PURPOSE
To clarify the primary oxidative stress response signaling pathways in trabecular meshwork (TM) cells and their effects on cell viability.
METHODS
Porcine TM cells were treated with 600 μM or 800 μM H₂O₂, and their time-dependent morphologic changes were observed. Phosphorylation of protein kinase B (Akt), ex... | 23,805,040 | D000818:Animals; D002070:Butadienes; D048430:Cell Shape; D002470:Cell Survival; D002867:Chromones; D006861:Hydrogen Peroxide; D007093:Imidazoles; D007150:Immunohistochemistry; D048031:JNK Mitogen-Activated Protein Kinases; D009025:Morpholines; D009570:Nitriles; D018384:Oxidative Stress; D010766:Phosphorylation; D051057... | Molecular vision | 2,013 | D002070:Butadienes; D002867:Chromones; D007093:Imidazoles; D009025:Morpholines; D009570:Nitriles; D011725:Pyridines; C113580:U 0126; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D006861:Hydrogen Peroxide; D051057:Proto-Oncogene Proteins c-akt; D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mito... | |
[Endoscopic retrograde cholangiopancreatography combined with laparoscopic cholecystectomy]. | In 11 of 82 patients undergoing laparoscopic cholecystectomy, preoperative endoscopic retrograde cholangiopancreatography (ERCP) was performed. Indications were biliary pancreatitis in 5 and suspected common bile duct (CBD) stones in the other 6 (based on US or liver function tests, or both). The biliary tree was norma... | 8,436,314 | D002760:Cholangiopancreatography, Endoscopic Retrograde; D017081:Cholecystectomy, Laparoscopic; D042882:Gallstones; D006801:Humans; D010195:Pancreatitis; D011300:Preoperative Care; D014463:Ultrasonography | Harefuah | 1,993 | ||
Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study. | BACKGROUND
Recent data suggest that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decrease fracture risk and increase bone mineral density (BMD).
METHODS
This cross-sectional study is set in southeastern Australia. We evaluated the association between statin use, fracture risk, and BMD in 1375 ... | 10.1001/archinte.162.5.537 | 11,871,921 | D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005265:Femoral Neck Fractures; D050723:Fractures, Bone; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008297:Male; D008875:Middle Aged; D014904:Wester... | Archives of internal medicine | 2,002 | D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors |
Computer-based anesthesiology paging system. | UNLABELLED
For more than a century, Mayo Clinic has used various communication strategies to optimize the efficiency of physicians. Anesthesiology has used colored wooden tabs, colored lights, and, most recently, a distributed video paging system (VPS) that was near the end of its useful life. A computer-based anesthes... | 10.1213/01.ane.0000063826.27415.5a | 12,818,966 | D000776:Anesthesiology; D003195:Computer Communication Networks; D003201:Computers; D008838:Microcomputers; D012984:Software | Anesthesia and analgesia | 2,003 | |
An investigation into the relationship between region specific quality of life and adverse tuberculosis treatment outcomes in Istanbul, Turkey. | BACKGROUND AND OBJECTIVE
Istanbul has the highest incidence of tuberculosis (TB) in Turkey. It is also the largest city, with considerable differences in quality of life across its urban regions. The aim of this study is to investigate the relationship between (i) the diverse quality of life across specific urban regio... | 24,674,616 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010349:Patient Compliance; D011788:Quality of Life; D012189:Retrospective Studies; D017211:Treatment Failure; D014397:Tuberc... | Revista portuguesa de pneumologia | 2,014 | ||
Acoustic analysis of the closing sounds of implanted prosthetic heart valves. | Previous in vitro studies [K. J. Reynolds, Ph.D. thesis (1994); K. J. Reynolds and R. O. Stephen, J. Acoust. Soc. Am. 97, 60-68 (1995)] have shown that it is possible to detect minor mechanical changes to a prosthetic heart valve by acoustic analysis of the valve's closing sounds. This current study investigates the so... | 10.1121/1.413663 | 7,608,408 | D000162:Acoustics; D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D012119:Respiration; D013016:Sound; D013997:Time Factors | The Journal of the Acoustical Society of America | 1,995 | |
A multi-compartment model for interneurons in the dorsal lateral geniculate nucleus. | GABAergic interneurons (INs) in the dorsal lateral geniculate nucleus (dLGN) shape the information flow from retina to cortex, presumably by controlling the number of visually evoked spikes in geniculate thalamocortical (TC) neurons, and refining their receptive field. The INs exhibit a rich variety of firing patterns:... | 10.1371/journal.pcbi.1002160 | 21,980,270 | D000200:Action Potentials; D000818:Animals; D002118:Calcium; D019295:Computational Biology; D003198:Computer Simulation; D003712:Dendrites; D055724:Electrophysiological Phenomena; D005829:Geniculate Bodies; D066298:In Vitro Techniques; D007395:Interneurons; D007473:Ion Channels; D007700:Kinetics; D051379:Mice; D008822:... | PLoS computational biology | 2,011 | D007473:Ion Channels; D002118:Calcium |
Short-term persistence of high health care costs in a nationally representative sample of children. | OBJECTIVES
Little is known about the persistence of health care costs in children. Determining whether children with high health expenses continue to have high expenses over time can help in the development of targeted programs and policies to decrease costs, plan equitable health insurance strategies, and provide insi... | 10.1542/peds.2005-2264 | 17,015,496 | D000293:Adolescent; D000367:Age Factors; D002648:Child; D002662:Child Health Services; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D019988:Disabled Children; D005260:Female; D017048:Health Care Costs; D019538:Health Care Surveys; D005102:Health Expenditures; D006285:Health Planning; D0068... | Pediatrics | 2,006 | |
Intracranial papillary endothelial hyperplasia (Masson's tumour) following gamma knife radiosurgery for temporal lobe epilepsy. | We present a rare case of intracranial papillary endothelial hyperplasia, or 'Masson's tumour,' following gamma knife radiosurgery for epilepsy. A 59-year-old woman presented with a 4-month history of escalating headaches and progressive neurological deficit. MR scan of brain showed enlargement of an enhancing right te... | 10.1136/practneurol-2016-001573 | 28,232,387 | D018952:Antigens, CD34; D001932:Brain Neoplasms; D004806:Ependymoma; D004833:Epilepsy, Temporal Lobe; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011183:Postoperative Complications; D016634:Radiosurgery | Practical neurology | 2,017 | D018952:Antigens, CD34 |
Interactions between the GroE chaperonins and rhodanese. Multiple intermediates and release and rebinding. | Efficient renaturation of urea-denatured rhodanese using the chaperonin GroE system requires GroEL, GroES, and ATP. At high concentrations this renaturation also requires the substrate thiosulfate to have been present during GroEL-rhodanese complex formation. When thiosulfate is present the GroEL-rhodanese complex can ... | 10.1074/jbc.270.37.21517 | 7,665,563 | D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D018835:Chaperonin 10; D018834:Chaperonin 60; D007700:Kinetics; D011485:Protein Binding; D011489:Protein Denaturation; D017510:Protein Folding; D013884:Thiosulfate Sulfurtransferase | The Journal of biological chemistry | 1,995 | D018835:Chaperonin 10; D018834:Chaperonin 60; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D013884:Thiosulfate Sulfurtransferase |
PreSurgMapp: a MATLAB Toolbox for Presurgical Mapping of Eloquent Functional Areas Based on Task-Related and Resting-State Functional MRI. | The main goal of brain tumor surgery is to maximize tumor resection while minimizing the risk of irreversible postoperative functional sequelae. Eloquent functional areas should be delineated preoperatively, particularly for patients with tumors near eloquent areas. Functional magnetic resonance imaging (fMRI) is a non... | 10.1007/s12021-016-9304-y | 27,221,107 | D000465:Algorithms; D001921:Brain; D001931:Brain Mapping; D001932:Brain Neoplasms; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011300:Preoperative Care; D012815:Signal Processing, Computer-Assisted; D012984:Software | Neuroinformatics | 2,016 |
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