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Elemental Metabolomics for Prediction of Term Gestational Outcomes Utilising 18-Week Maternal Plasma and Urine Samples. | A normal pregnancy is essential to establishing a healthy start to life. Complications during have been associated with adverse perinatal outcomes and lifelong health problems. The ability to identify risk factors associated with pregnancy complications early in gestation is vitally important for preventing negative fo... | 10.1007/s12011-020-02127-6 | 32,239,374 | D005260:Female; D006801:Humans; D007231:Infant, Newborn; D055432:Metabolomics; D010920:Placenta; D010949:Plasma; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth | Biological trace element research | 2,021 | |
A Statistical Model to Analyze Clinician Expert Consensus on Glaucoma Progression using Spatially Correlated Visual Field Data. | PURPOSE
We developed a statistical model to improve the detection of glaucomatous visual field (VF) progression as defined by the consensus of expert clinicians.
METHODS
We developed new methodology in the Bayesian setting to properly model the progression status of a patient (as determined by a group of expert clini... | 10.1167/tvst.5.4.14 | 27,622,079 | Translational vision science & technology | 2,016 | ||
Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarker. | Barrett's esophagus (BE) is a precursor of the esophageal adenocarcinoma (EAC). BE- development and its progression to cancer is associated with gastroesophageal reflux disease. However, there is currently no molecular risk prediction model that accurately identifies patients at high risk for EAC. Here, we investigated... | 10.18632/oncotarget.28198 | 35,178,191 | D000230:Adenocarcinoma; D000818:Animals; D001471:Barrett Esophagus; D015415:Biomarkers; D002471:Cell Transformation, Neoplastic; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms; D006801:Humans; D053583:Interleukin-1beta; D008679:Metaplasia; D051379:Mice; D059506:Telomere Shortening | Oncotarget | 2,022 | D015415:Biomarkers; C508585:IL1B protein, human; D053583:Interleukin-1beta |
p-Nitrophenol removal by combination of powdered activated carbon adsorption and ultrafiltration - comparison of different operational modes. | Ultrafiltration is classified as a low-pressure membrane technology which effectively removes particulate matter and microorganisms and to a certain extent dissolved organic matter (15-25%) and colour. The technology has been optimized and is becoming competitive compared to conventional processes for larger scale plan... | 10.1016/j.watres.2008.07.009 | 18,752,826 | D000327:Adsorption; D002606:Charcoal; D009596:Nitrophenols; D015203:Reproducibility of Results; D014462:Ultrafiltration; D018508:Water Purification | Water research | 2,008 | D009596:Nitrophenols; D002606:Charcoal |
Pap smear screening for small cell carcinoma of the uterine cervix: a case series and review of the literature. | OBJECTIVE
Small cell carcinoma of the uterine cervix (SMCC) is extremely rare, and an aggressive disease that proliferates rapidly. It was often reported that the diagnostic accuracy of cytologic smears in diagnosing SMCC was low. This is a report of the Severance Hospital experience with the patients suffering from SM... | 10.3802/jgo.2011.22.1.39 | 21,607,094 | Journal of gynecologic oncology | 2,011 | ||
Cross-Cultural Adaptation and Validation of the Italian Version of SWAL-QOL. | The aim of the study was to evaluate the reliability and validity of the Italian SWAL-QOL (I-SWAL-QOL). The study consisted of five phases: item generation, reliability analysis, normative data generation, validity analysis, and responsiveness analysis. The item generation phase followed the five-step, cross-cultural, ... | 10.1007/s00455-016-9720-z | 27,444,734 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D065246:Culturally Competent Care; D003680:Deglutition Disorders; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011788:Quality of Life; D015203:Reproducibility o... | Dysphagia | 2,016 | |
In vitro determination of transdermal permeation of synthetic musks and estimated dermal uptake through usage of personal care products. | Synthetic musks, chemical constituents of personal care products, enter the human body through dermal contact. Elucidation of the mechanisms underlying transdermal permeation of synthetic musks should enhance our understanding of their uptake and distribution in human skin and allow accurate evaluation of associated hu... | 10.1016/j.chemosphere.2017.01.001 | 28,129,620 | D000279:Administration, Cutaneous; D000328:Adult; D000818:Animals; D001578:Benzopyrans; D003358:Cosmetics; D004781:Environmental Exposure; D006801:Humans; D066298:In Vitro Techniques; D012867:Skin; D012869:Skin Absorption; D013552:Swine; D013764:Tetrahydronaphthalenes; D014992:Xylenes | Chemosphere | 2,017 | D001578:Benzopyrans; D003358:Cosmetics; D013764:Tetrahydronaphthalenes; D014992:Xylenes; C033119:galaxolide; C031447:musk xylene; C033116:acetyl methyl tetramethyl tetralin; C031448:musk ketone |
The impact of genetic and experimental studies on classification and therapy of the epilepsies. | Different types of epilepsy are associated with gene mutations, in which seizures can be the only symptom (genetic epilepsies) or be one of the elements of complex clinical pictures that are often progressive over time (epileptic or epileptogenic encephalopathies). In epileptogenic encephalopathies, epileptic seizures ... | 10.1016/j.neulet.2017.05.026 | 28,522,348 | D000818:Animals; D001927:Brain Diseases; D004827:Epilepsy; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation; D010641:Phenotype; D012640:Seizures | Neuroscience letters | 2,018 | |
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease. | The search for new drug candidates against Alzheimer's disease (AD) remains a complex challenge for medicinal chemists due to its multifactorial pathogenesis and incompletely understood physiopathology. In this context, we have explored the molecular hybridization of pharmacophore structural fragments from known bioact... | 10.1016/j.bmc.2022.116952 | 35,930,852 | D000110:Acetylcholinesterase; D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D015195:Drug Design; D006801:Humans; D006835:Hydrazones; D008024:Ligands; D015394:Molecular Structure; D009447:Neuroblastoma; D018696:Neuroprotective Agents; D010880:Piperidin... | Bioorganic & medicinal chemistry | 2,022 | D016229:Amyloid beta-Peptides; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D006835:Hydrazones; D008024:Ligands; D018696:Neuroprotective Agents; D010880:Piperidines; D000110:Acetylcholinesterase |
Regulation of epithelial chloride channels by protein phosphatase. | A combination of planar bilayer and patch-clamp techniques was used to determine whether apical membrane Cl- channels of shark (Squalus acanthias) rectal gland (SRG) were regulated by a phosphorylating and dephosphorylating cycle. In channel reconstitution studies, apical membrane vesicles of SRG were purified, incubat... | 10.1152/ajpcell.1991.260.6.C1217 | 1,711,776 | D000255:Adenosine Triphosphate; D000818:Animals; D002462:Cell Membrane; D018118:Chloride Channels; D002712:Chlorides; D005576:Colforsin; D004284:Dogfish; D004988:Ethers, Cyclic; D007473:Ion Channels; D007700:Kinetics; D008051:Lipid Bilayers; D008565:Membrane Proteins; D019319:Okadaic Acid; D010749:Phosphoprotein Phosph... | The American journal of physiology | 1,991 | D018118:Chloride Channels; D002712:Chlorides; D004988:Ethers, Cyclic; D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D005576:Colforsin; D019319:Okadaic Acid; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases |
Variable clinical phenotypes of alpha-thalassemia syndromes. | Genetic mutations of the alpha genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of alpha-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in ... | 10.1100/tsw.2009.69 | 19,618,088 | D006580:Genetic Carrier Screening; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening; D010641:Phenotype; D013577:Syndrome; D017085:alpha-Thalassemia | TheScientificWorldJournal | 2,009 | |
Equivalent Efficacy but Different Safety Profiles of Gemcitabine Plus Nab-Paclitaxel and FOLFIRINOX in Metastatic Pancreatic Cancer. | FOLFIRINOX (FFX) and gemcitabine + nab-paclitaxel (GN) are the most common chemotherapy regimens in first-line treatment of metastatic pancreatic cancer (PC). They have not been compared each other in a prospective trial, but only in retrospective studies, which can thus be affected by several biases. In order to overc... | 10.3390/biom11060780 | 34,067,288 | D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D003841:Deoxycytidine; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D000077150:Oxaliplat... | Biomolecules | 2,021 | C000627770:folfirinox; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000077146:Irinotecan; D017239:Paclitaxel; D002955:Leucovorin; D005472:Fluorouracil; D000093542:Gemcitabine |
Comparison of triacylglycerol synthesis in rat brown and white adipocytes. Effects of hypothyroidism and streptozotocin-diabetes on enzyme activities and metabolic fluxes. | 1. Adipocytes were isolated from the interscapular brown fat and the epididymal white fat of normal, streptozotocin-diabetic and hypothyroid rats. 2. Measurements were made of the maximum rate of triacylglycerol synthesis by monitoring the incorporation of [U-14C]glucose into acylglycerol glycerol in the presence of pa... | 10.1042/bj2500325 | 3,355,527 | D000273:Adipose Tissue; D002001:Adipose Tissue, Brown; D000367:Age Factors; D000818:Animals; D003921:Diabetes Mellitus, Experimental; D004951:Esterification; D005227:Fatty Acids; D005947:Glucose; D007037:Hypothyroidism; D066298:In Vitro Techniques; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred St... | The Biochemical journal | 1,988 | D005227:Fatty Acids; D014280:Triglycerides; D005947:Glucose |
A new method for performing continuous manometry during pleural effusion drainage. | BACKGROUND
Pleural manometry can predict the presence of trapped lung and guide large-volume thoracentesis. The current technique for pleural manometry transduces pressure from the needle or intercostal catheter, necessitating intermittent cessation of fluid drainage at the time of pressure recordings.
OBJECTIVES
To ... | 10.1159/000358842 | 24,820,119 | D000368:Aged; D003948:Diagnostic Techniques, Respiratory System; D004322:Drainage; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D010996:Pleural Effusion; D011446:Prospective Studies | Respiration; international review of thoracic diseases | 2,014 | |
Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies. | Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the maintenance and the transfer of a correct genome to daughter cells through a selection of DNA repair, cell cycle regulation, and programmed cell death processes. Canoni... | 10.3390/cancers13153819 | 34,359,720 | Cancers | 2,021 | ||
Hamster zonae pellucidae cannot induce physiological acrosome reactions in chemically capacitated hamster spermatozoa in the absence of albumin. | Cauda epididymal hamster spermatozoa were capacitated with D-penicillamine in a chemically defined (protein-free) medium (= "chemical" capacitation). Hamster zonae pellucidae were incapable of inducing functional acrosome reactions in chemically capacitated hamster sperm in a protein-free medium during sperm-egg coincu... | 10.1095/biolreprod41.1.117 | 2,804,202 | D000177:Acrosome; D000418:Albumins; D000818:Animals; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D010063:Ovum; D010396:Penicillamine; D013075:Sperm Capacitation; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa; D015044:Zona Pellucida | Biology of reproduction | 1,989 | D000418:Albumins; D010396:Penicillamine |
Major trends in the microbial etiology of nosocomial infection. | To determine trends in the microbial etiology of nosocomial infections in the 1980s, surveillance data on the microbiology of documented nosocomial infection reported to the National Nosocomial Infections Surveillance System and from the University of Michigan Hospital were analyzed. Antimicrobial susceptibility data o... | 10.1016/0002-9343(91)90346-y | 1,928,195 | D001419:Bacteria; D001424:Bacterial Infections; D002177:Candidiasis; D003428:Cross Infection; D006801:Humans; D014481:United States | The American journal of medicine | 1,991 | |
Dietary fat and blood pressure in humans. | The regulation of blood pressure by dietary means represents an important approach toward the reduction of morbidity and mortality of heart disease. The results of our dietary intervention studies demonstrated that a lowered saturated fat, higher polyunsaturated fat diet had a lowering effect on both systolic and diast... | 2,189,038 | D000328:Adult; D001794:Blood Pressure; D004041:Dietary Fats; D005260:Female; D006801:Humans; D008041:Linoleic Acids; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic | Klinische Wochenschrift | 1,990 | D004041:Dietary Fats; D008041:Linoleic Acids | |
Overexpression of the 18A2/mts1 gene and down-regulation of the TIMP-2 gene in invasive human glioma cell lines in vitro. | Invasion of the reconstituted extracellular matrix composite, Matrigel, by eight human glioma-derived cell lines and human fetal brain cells was assessed in vitro using 8 microns polycarbonate filters in a modified Boyden migration chamber. With the exception of one low grade glioma derived cell line, all lines studied... | 10.1111/j.1365-2990.1994.tb01017.x | 7,898,625 | D015152:Blotting, Northern; D001921:Brain; D002478:Cells, Cultured; D015536:Down-Regulation; D015870:Gene Expression; D005910:Glioma; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D009363:Neoplasm Proteins; D011506:Proteins; D019716:Tissue Inhibitor of Metalloproteinase-2 | Neuropathology and applied neurobiology | 1,994 | D009363:Neoplasm Proteins; D011506:Proteins; D019716:Tissue Inhibitor of Metalloproteinase-2 |
Cervical spinal arachnoid cyst in a dog. | An 18-month-old, intact male Akita presented with a 12-month history of progressive ataxia, hypermetria, and loss of conscious proprioception of the thoracic and pelvic limbs. Neurological examination and myelography localized a lesion at cervical vertebrae 1 and 2 consistent with an arachnoid cyst. Hemilaminectomy and... | 10,738,602 | D000818:Animals; D016080:Arachnoid Cysts; D002574:Cervical Vertebrae; D004283:Dog Diseases; D004285:Dogs; D007796:Laminectomy; D008297:Male | The Canadian veterinary journal = La revue veterinaire canadienne | 2,000 | ||
Investigating structural changes induced by nucleotide binding to RecA using difference FTIR. | Nucleotide binding to RecA results in either the high-DNA affinity form (Adenosine 5'-triphosphate (ATP)-bound) or the more inactive protein conformation associated with a lower affinity for DNA (Adenosine 5'-diphosphate (ADP)-bound). Many of the key structural differences between the RecA-ATP and RecA-ADP bound forms ... | 10.1016/S0006-3495(02)75566-5 | 11,916,875 | D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003903:Deuterium; D004305:Dose-Response Relationship, Drug; D006859:Hydrogen; D006868:Hydrolysis; D009711:Nucleotides; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011938:Rec A Recombinases; D013050:Spectrom... | Biophysical journal | 2,002 | D009711:Nucleotides; D014867:Water; D000244:Adenosine Diphosphate; D006859:Hydrogen; D000255:Adenosine Triphosphate; D003903:Deuterium; D011938:Rec A Recombinases |
Immunohistochemical Expression of Progesterone Receptors in Nonmeningothelial Central Nervous System Tumors. | INTRODUCTION
Immunostaining of progesterone receptors (PRs) has been described as a prognostic factor related to recurrences in meningiomas. However, its expression in other primary intracranial tumors has been poorly studied. In this paper, we compare the pattern of expression of the receptor in meningiomas with that ... | 10.1097/PAI.0000000000000318 | 26,766,127 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011980:Receptors, Progesterone; D055815:Young Adult | Applied immunohistochemistry & molecular morphology : AIMM | 2,017 | D011980:Receptors, Progesterone |
Conventional Versus Distal Laparoscopic One-Anastomosis Gastric Bypass: a Randomized Controlled Trial with 1-Year Follow-up. | BACKGROUND
There is no consensus on the ideal small bowel length that should be bypassed in laparoscopic one-anastomosis gastric bypass (OAGB). This study aimed to compare the safety and efficacy of conventional versus distal techniques of laparoscopic OAGB.
METHODS
This randomized controlled trial involved 60 adults... | 10.1007/s11695-019-03991-5 | 31,177,364 | D000328:Adult; D002784:Cholesterol; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006454:Hemoglobins; D006801:Humans; D007501:Iron; D010535:Laparoscopy; D008297:Male; D010281:Parathyroid Hormone; D011788:Quality of Life; D012709:Serum Albumin; D014280:Triglycerides; D015431:Weight Loss | Obesity surgery | 2,019 | D006454:Hemoglobins; D010281:Parathyroid Hormone; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D007501:Iron |
EMT-cancer cells-derived exosomal miR-27b-3p promotes circulating tumour cells-mediated metastasis by modulating vascular permeability in colorectal cancer. | BACKGROUND
Metastasis is the main cause of death in colorectal cancer (CRC). Circulating tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which underwent epithelial-mesenchymal transition (EMT), are associated with metastasis and responsible for poor prognosis. EMT cancer cells modulate ... | 10.1002/ctm2.595 | 34,936,736 | D000368:Aged; D002199:Capillary Permeability; D002465:Cell Movement; D049109:Cell Proliferation; D015179:Colorectal Neoplasms; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulati... | Clinical and translational medicine | 2,021 | C000711187:MIRN27b microRNA, human; D035683:MicroRNAs |
Followup of psychoanalysis five to ten years after termination: I. Stability of change. | Seven out of 17 patients interviewed in a long-term followup of psychoanalysis showed either improvement in psychological functioning or a retention of psychological gains they had made during the course of psychoanalysis. Six patients deteriorated in their psychological functioning, but their gains were restored with ... | 10.1177/000306519003800209 | 2,362,072 | D000339:Affect; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009769:Object Attachment; D011572:Psychoanalysis; D011936:Reality Testing; D012649:Self Concept; D013997:Time Factors; D014937:Work | Journal of the American Psychoanalytic Association | 1,990 | |
Towards optical frequency geopotential difference measurements via a flying drone. | Geopotential and orthometric height differences between distant points can be measured via timescale comparisons between atomic clocks. Modern optical atomic clocks achieve statistical uncertainties on the order of 10-18, allowing height differences of around 1 cm to be measured. Frequency transfer via free-space optic... | 10.1364/OE.483767 | 37,157,357 | Optics express | 2,023 | ||
Ganaxolone: A New Treatment for Neonatal Seizures. | Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce "de novo" injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of... | 10.3389/fncel.2017.00246 | 28,878,622 | Frontiers in cellular neuroscience | 2,017 | ||
Predictive models and early postoperative recurrence evaluation for hepatocellular carcinoma based on gadoxetic acid-enhanced MR imaging. | BACKGROUND
The prognosis of hepatocellular carcinoma (HCC) is still poor largely due to the high incidence of recurrence. We aimed to develop and validate predictive models of early postoperative recurrence for HCC using clinical and gadoxetic acid-enhanced magnetic resonance (MR) imaging-based findings.
METHODS
In t... | 10.1186/s13244-022-01359-5 | 36,617,581 | Insights into imaging | 2,023 | ||
Operative Efficiency in Deep Inferior Epigastric Perforator Flap Reconstruction: Key Concepts and Implementation. | The deep inferior epigastric perforator flap has become one of the most popular approaches for autologous breast reconstruction after mastectomy. As much of health care has moved to a value-based approach, reducing complications, operative time, and length of stay in deep inferior flap reconstruction is becoming increa... | 10.1016/j.cps.2022.11.002 | 36,813,406 | D006801:Humans; D005260:Female; D008408:Mastectomy; D061525:Perforator Flap; D001943:Breast Neoplasms; D019074:Epigastric Arteries; D016462:Mammaplasty; D012189:Retrospective Studies | Clinics in plastic surgery | 2,023 | |
Disc battery swallowers--two contrasting cases. | Increased use and availability of disc batteries has been reflected in the number of children presenting following ingestion of such batteries. An expectant, non operative policy is advocated. Battery manufacturers, however, recommend immediate removal of the battery. Two cases presented here illustrate contrasting mod... | 10.1177/003693309003500209 | 2,374,907 | D002057:Burns, Chemical; D002675:Child, Preschool; D011211:Electric Power Supplies; D005260:Female; D005547:Foreign Bodies; D006801:Humans; D007223:Infant; D008297:Male; D008787:Metoclopramide; D013270:Stomach | Scottish medical journal | 1,990 | D008787:Metoclopramide |
Factors determining long-term outcomes and survival in patients with coronary artery disease and ventricular tachyarrhythmias: a single center experience. | A Single-Center Experience. The influence, after ICD implantation, of concomitant CABG, angioplasty, and other antiischemic therapeutic interventions, like treatment with beta-blockers, on outcome and mortality of patients with VT or VF due to CAD remains uncertain. The univariate and multivariate risks of recurrence o... | 10.1111/j.1540-8159.2000.tb07059.x | 11,139,964 | D000319:Adrenergic beta-Antagonists; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000806:Angiotensin-Converting Enzyme Inhibitors; D001026:Coronary Artery Bypass; D003327:Coronary Disease; D017147:Defibrillators, Implantable; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Hu... | Pacing and clinical electrophysiology : PACE | 2,000 | D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors |
Noninvasive and minimally-invasive optical monitoring technologies. | With recent advancements in micro-fabrication and nano-fabrication techniques as well as advancements in the photonics industry, there is now the potential to develop less invasive portable sensors for monitoring micronutrients and other substances used to assess overall health. There have been many technology innovati... | 10.1093/jn/131.5.1596S | 11,340,124 | D002648:Child; D005260:Female; D005947:Glucose; D006801:Humans; D018977:Micronutrients; D009752:Nutritional Status; D009904:Optical Rotation; D011048:Polarography; D013059:Spectrum Analysis, Raman | The Journal of nutrition | 2,001 | D018977:Micronutrients; D005947:Glucose |
Biomass recalcitrance: a multi-scale, multi-factor, and conversion-specific property. | Recalcitrance of plant biomass to enzymatic hydrolysis for biofuel production is thought to be a property conferred by lignin or lignin-carbohydrate complexes. However, chemical catalytic and thermochemical conversion pathways, either alone or in combination with biochemical and fermentative pathways, now provide avenu... | 10.1093/jxb/erv267 | 26,060,266 | D018533:Biomass; D006868:Hydrolysis; D008031:Lignin; D010944:Plants | Journal of experimental botany | 2,015 | C036909:lignocellulose; D008031:Lignin |
Visual Search Asymmetry Due to the Relative Magnitude Represented by Number Symbols. | In visual search tasks, physically large target stimuli are more easily identified among small distractors than are small targets among large distractors. The present study extends this finding by presenting preliminary evidence of a new search asymmetry: stimuli that symbolically represent larger magnitude are identif... | 10.3390/vision5030042 | 34,564,340 | Vision (Basel, Switzerland) | 2,021 | ||
Basic principles of electrohaemodynamics. | Electrohaemodynamics (EHD) is a method of measuring cardiac output continuously, also cardiac index, stroke volume, blood flow through limbs, vascular resistance, useful work output from the heart, elastic properties of arterial walls, and contractile and rate of energy generation properties of heart muscle. The method... | 10.1016/0141-5425(81)90101-1 | 7,464,087 | D002302:Cardiac Output; D004548:Elasticity; D006321:Heart; D006439:Hemodynamics; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009206:Myocardium; D010992:Plethysmography, Impedance | Journal of biomedical engineering | 1,981 | |
Extraction of the essential oil from endemic Origanum bilgeri P.H.Davis with two different methods: comparison of the oil composition and antibacterial activity. | The antibacterial activity and chemical composition of the essential oils (EOs) isolated from Origanum bilgeri P.H.Davis by two different extraction methods, i.e., hydrodistillation (HD) and solvent-free microwave extraction (SFME), were examined. This endemic Origanum species had shown very good antibacterial activity... | 10.1002/cbdv.201100259 | 22,782,881 | D000900:Anti-Bacterial Agents; D001419:Bacteria; D002623:Chemistry Techniques, Analytical; D008401:Gas Chromatography-Mass Spectrometry; D009822:Oils, Volatile; D031341:Origanum; D035261:Plant Components, Aerial | Chemistry & biodiversity | 2,012 | D000900:Anti-Bacterial Agents; D009822:Oils, Volatile |
Treatment of large acetabular defects: a surgical technique utilizing impaction grafting into a metallic mesh. | BACKGROUND
Revision total hip arthroplasty in cases with severe acetabular bone loss is challenging. In the presence of combined cavitary and segmental defects without superior acetabular coverage, reconstructions with a structural acetabular allograft protected by a cage or a custom-made triflange cage have been the t... | 10.1007/s11420-013-9350-z | 24,426,876 | HSS journal : the musculoskeletal journal of Hospital for Special Surgery | 2,013 | ||
The mouse pink-eyed dilution gene: association with human Prader-Willi and Angelman syndromes. | Complementary DNA clones from the pink-eyed dilution (p) locus of mouse chromosome 7 were isolated from murine melanoma and melanocyte libraries. The transcript from this gene is missing or altered in six independent mutant alleles of the p locus, suggesting that disruption of this gene results in the hypopigmentation ... | 10.1126/science.257.5073.1121 | 1,509,264 | D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins; D002884:Chromosomes, Human, Pair 15; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008544:Melanocytes; D008546:Melanoma, Experimental; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D051379:Mice; D008817:Mice, Mutant St... | Science (New York, N.Y.) | 1,992 | D002352:Carrier Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C489600:OCA2 protein, human; D011506:Proteins; C076239:P protein, mouse; D004247:DNA |
Assessing the acceptability of incentivising HPV vaccination consent form return as a means of increasing uptake. | BACKGROUND
Uptake of human papillomavirus (HPV) vaccination is high overall but there are disparities in uptake, particularly by ethnicity. Incentivising vaccination consent form return is a promising approach to increase vaccination uptake. As part of a randomised feasibility trial we qualitatively assessed the accept... | 10.1186/s12889-018-5278-z | 29,558,923 | D000293:Adolescent; D032962:Consent Forms; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D009042:Motivation; D030361:Papillomavirus Infections; D053918:Papillomavirus Vaccines; D010290:Parents; D010342:Patient Acceptance of Health Care; D036301:Qualitative Research; D012201:Reward; D011795:Surveys and Qu... | BMC public health | 2,018 | D053918:Papillomavirus Vaccines |
The Parent-Child Relationship and Posttreatment Child Outcomes Across Two Treatments for Oppositional Defiant Disorder. | This study examined the degree to which the parent-child relationship uniquely predicted clinical outcomes in externalizing problems and adaptive skills in children meeting diagnostic criteria for oppositional defiant disorder and whether facets of this relationship moderated the effects of two unique psychosocial trea... | 10.1080/15374416.2018.1555761 | 30,730,774 | D000293:Adolescent; D000328:Adult; D019958:Attention Deficit and Disruptive Behavior Disorders; D002648:Child; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D010287:Parent-Child Relations; D010290:Parents; D016896:Treatment Outcome | Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 | 2,020 | |
Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. | INTRODUCTION
To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased cerebral edema.
METHODS
We prospectively enrolled and collecte... | 10.1016/j.jstrokecerebrovasdis.2008.09.012 | 19,251,191 | D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001921:Brain; D001929:Brain Edema; D002543:Cerebral Hemorrhage; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D... | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2,009 | D053327:Apolipoprotein E4; D001057:Apolipoproteins E |
Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation. | The aim of this study was to investigate the role of oxidative stress in cystine crystal formation and whether salvianolic acid B, a natural antioxidant, could prevent cystine-mediated oxidative injury in vivo and in vitro. The levels of oxidative stress and antioxidase activity in cystine stone patients were assessed.... | 10.1007/s00240-019-01114-4 | 30,778,619 | D000818:Animals; D001572:Benzofurans; D002478:Cells, Cultured; D003553:Cystine; D006801:Humans; D007669:Kidney Calculi; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018384:Oxidative Stress | Urolithiasis | 2,019 | D001572:Benzofurans; D003553:Cystine; C076944:salvianolic acid B |
Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma. | Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with proximal gains and telomeric losses. Whether this lymphoma is a distinct category or a particular va... | 10.3324/haematol.2018.207928 | 30,733,272 | D000293:Adolescent; D000328:Adult; D002051:Burkitt Lymphoma; D002648:Child; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D004247:DNA; D004252:DNA Mutational Analysis; D005260:Female; D018628:Gene Dosage; D020869:Gene Expression Profiling; D018858:Germinal Center; D006801:Humans; D007150:Immunohi... | Haematologica | 2,019 | D004247:DNA |
Dataset of an actual life-risk insurance portfolio. | The foundation of the insurance business is built on data, the latter being one of the most valuable assets of any insurer. In fact, the risk structure to which an insurance company is exposed can actually be deduced by reviewing its customer database. It is not surprising, therefore, that access to real insurance data... | 10.1016/j.dib.2022.108655 | 36,426,067 | Data in brief | 2,022 | ||
[The concept of basic therapy of chronic polyarthritis with D-penicillamine: clinical experiences over 10 years]. | Rheumatoid arthritis is a chronic lifelong disease, facts which must be considered when concepts of therapy are developed. This paper reports retrospectively analyzed results of long-term therapy using D-penicillamine. One-hundred-sixteen patients were selected for critical analysis from among 257 treated patients. Jud... | 3,145,661 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid; D001175:Arthrography; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010396:Penicillamine; D012189:Retrospectiv... | Zeitschrift fur Rheumatologie | 1,988 | D002097:C-Reactive Protein; D010396:Penicillamine | |
Reliability and validity of the Turkish version of the Physical Activity Questionnaire for Older Children (PAQ-C) | Background/aim
The Physical Activity Questionnaire for Older Children (PAQ-C) is one of the most frequently used questionnaires for evaluating moderate to vigorous levels of physical activity in children. However, a Turkish version of the questionnaire was not available. This study aimed to create a... | 10.3906/sag-1806-212 | 30,764,593 | D000293:Adolescent; D002648:Child; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014421:Turkey | Turkish journal of medical sciences | 2,019 | |
Low molecular weight serine proteinase inhibitors of the human intervertebral disc. | Human lumbar disc tissue when extracted with 4M GuHCl and subjected to dissociative CsCl density gradient ultracentrifugation yielded trypsin inhibitor activity in the low bouyant density fractions (rho less than or equal to 1.38 g/ml). Disc proteoglycans sedimented in the high bouyant density fractions (rho greater th... | 3,483,324 | D002499:Centrifugation, Density Gradient; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D006801:Humans; D007403:Intervertebral Disc; D008970:Molecular Weight; D011509:Proteoglycans; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors | Biochemistry international | 1,987 | D011509:Proteoglycans; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors | |
Three-dimensional catheter navigation of airways using continuous-sweep limited angle fluoroscopy on a C-arm. | Purpose: To develop an imaging-based 3D catheter navigation system for transbronchial procedures including biopsy and tumor ablation using a single-plane C-arm x-ray system. The proposed system provides time-resolved catheter shape and position as well as motion compensated 3D airway roadmaps. Approach: A continuous-sw... | 10.1117/1.JMI.8.5.055001 | 34,671,695 | Journal of medical imaging (Bellingham, Wash.) | 2,021 | ||
Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. | Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients. In this study, we found that the expressions of anti-oxidant proteins (gamma-glutamylcysteine ligase heavy chain (gamma-GCL h), heme oxygenase-1, thioredoxin and peroxiredoxin1) in TAM-resistant MCF-7 (TAMR-MCF-7) cells w... | 10.1016/j.freeradbiomed.2008.05.011 | 18,539,158 | D018931:Antineoplastic Agents, Hormonal; D000975:Antioxidants; D001483:Base Sequence; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D005721:Glutamate-Cysteine Ligase; D006801:Humans; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; D034741:RNA, Small Interfering; D011960:Receptors, Estrogen; D015398:S... | Free radical biology & medicine | 2,008 | D018931:Antineoplastic Agents, Hormonal; D000975:Antioxidants; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; D034741:RNA, Small Interfering; D011960:Receptors, Estrogen; D013629:Tamoxifen; D005721:Glutamate-Cysteine Ligase |
Studies on the role of lipid peroxidation in the acute toxicity of TCDD in rats. | Lipid peroxidation has been shown to be enhanced following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), but its role in TCDD toxicity is unclear. The present study was undertaken to further elucidate the relations between lipid peroxidation and TCDD lethality. A time course and dose-response experiment in Lo... | 10.1111/j.1600-0773.1990.tb00769.x | 2,371,248 | D000818:Animals; D000975:Antioxidants; D001835:Body Weight; D056486:Chemical and Drug Induced Liver Injury; D004147:Dioxins; D004731:Endotoxins; D005227:Fatty Acids; D015227:Lipid Peroxidation; D008099:Liver; D008297:Male; D000072317:Polychlorinated Dibenzodioxins; D051381:Rats; D011919:Rats, Inbred Strains; D013217:St... | Pharmacology & toxicology | 1,990 | D000975:Antioxidants; D004147:Dioxins; D004731:Endotoxins; D005227:Fatty Acids; D000072317:Polychlorinated Dibenzodioxins; D013858:Thiobarbiturates |
A reversible ischemia model in gerbil cochlea. | A completely reversible cochlear-ischemia animal model was developed, and an initial study of ischemia/reperfusion-induced cochlear function change is presented. The bulla of the anesthetized gerbil was opened through a ventral approach and the anterior inferior cerebellar artery and its branches were exposed. Cochlear... | 10.1016/0378-5955(95)00192-1 | 8,647,743 | D000818:Animals; D001158:Arteries; D003051:Cochlea; D015834:Cochlear Diseases; D004195:Disease Models, Animal; D007758:Ear, Inner; D005849:Gerbillinae; D006198:Hair Cells, Auditory; D007511:Ischemia; D017078:Laser-Doppler Flowmetry; D017084:Otoacoustic Emissions, Spontaneous; D012039:Regional Blood Flow; D015427:Reperf... | Hearing research | 1,995 | |
Paradoxical changes of muscle glutamine release during hyperinsulinemia euglycemia and hypoglycemia in humans: further evidence for the glucose-glutamine cycle. | Insulin suppresses and counterregulatory hormones increase proteolysis. Therefore, if proteolysis were a major factor determining amino acid fluxes in plasma, one would expect release of glutamine into plasma to be suppressed by insulin under euglycemic conditions and to be stimulated under hypoglycemic conditions. How... | 10.1016/j.metabol.2004.04.009 | 15,334,386 | D000328:Adult; D001786:Blood Glucose; D005260:Female; D005542:Forearm; D005947:Glucose; D005973:Glutamine; D006728:Hormones; D006801:Humans; D006946:Hyperinsulinism; D007003:Hypoglycemia; D007700:Kinetics; D008297:Male; D018482:Muscle, Skeletal | Metabolism: clinical and experimental | 2,004 | D001786:Blood Glucose; D006728:Hormones; D005973:Glutamine; D005947:Glucose |
Suicide prevention centers. Ecological study of effectiveness. | While suicide prevention services are continually expanding, efforts to measure their efficacy are seldom found in the literature. This study examines the effect of suicide prevention centers in North Carolina on the suicide rate in 1970. The data are examined in a ecological context, i.e., pertinent demographic variab... | 10.1097/00005053-197701000-00004 | 830,797 | D000328:Adult; D000367:Age Factors; D003156:Community Mental Health Services; D003419:Crisis Intervention; D004637:Emergency Services, Psychiatric; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage; D008605:Mental Health Services; D008875:Middle Aged; D009657:North Carolina; D012737:Sex Factors; D013405:Su... | The Journal of nervous and mental disease | 1,977 | |
[Recurrent functional ovarian cysts following laparoscopy fenestration]. | The laparoscopic fenestration of functional ovarian cysts with a benign appearance is well known. After aspiration of the contents of the cyst, a window is cut in the cyst wall for an endocystic inspection. In this way, samples for cytology as well as histopathology are obtained. A laparoscopic fenestration was perform... | 10.1055/s-2008-1036293 | 2,533,120 | D004715:Endometriosis; D005260:Female; D006801:Humans; D010535:Laparoscopy; D009364:Neoplasm Recurrence, Local; D010048:Ovarian Cysts; D010051:Ovarian Neoplasms; D011183:Postoperative Complications; D012008:Recurrence; D013724:Teratoma; D000267:Tissue Adhesions | Geburtshilfe und Frauenheilkunde | 1,989 | |
Nomograms to help inform women considering Down's syndrome screening. | OBJECTIVE
To derive graphical information for use in counselling women considering whether or not to have maternal serum screening for Down's syndrome.
DESIGN
Statistical modelling of the frequency distribution of estimated Down's syndrome risk for four marker combinations.
RESULTS
Nomograms are provided showing fo... | 10.1016/0301-2115(95)02514-6 | 8,902,435 | D006063:Chorionic Gonadotropin; D004314:Down Syndrome; D004964:Estriol; D005189:False Positive Reactions; D005260:Female; D005315:Fetal Diseases; D005817:Genetic Counseling; D006801:Humans; D008403:Mass Screening; D008423:Maternal Age; D011296:Prenatal Diagnosis; D012307:Risk Factors; D000509:alpha-Fetoproteins | European journal of obstetrics, gynecology, and reproductive biology | 1,996 | D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol |
The immune response to apoptotic cells. | Programmed cell death (PCD) can be divided into two distinct but linked sequential processes, killing of the cells and removal of the dead cells, which may be a neighboring cell or a professional phagocyte. Following internalization of the apoptotic cell, the phagocyte typically triggers neither the development of a pr... | 10.1111/j.1749-6632.1999.tb07933.x | 10,668,475 | D000818:Animals; D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D000917:Antibody Formation; D017209:Apoptosis; D004277:DNA, Single-Stranded; D005720:Gamma Rays; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D017710:Lymphocyte Transfusion; D008214:Lymphocytes; D051379:Mice; D008807:Mice, Inb... | Annals of the New York Academy of Sciences | 1,999 | D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D007075:Immunoglobulin M |
Determination of affinity constants and response factors of the noncovalent dimer of gramicidin by electrospray ionization mass spectrometry and mathematical modeling. | The dimerization of gramicidin, a 15-residue membrane peptide, in solution can be viewed as a model for protein-protein interactions. We reported previously that the dimer can be observed when electrosprayed from organic solvents and that the abundances of the dimer depends on the dielectric constant of the solvent. He... | 10.1016/j.jasms.2005.04.001 | 15,914,025 | D000900:Anti-Bacterial Agents; D019281:Dimerization; D006096:Gramicidin; D015233:Models, Statistical; D021241:Spectrometry, Mass, Electrospray Ionization | Journal of the American Society for Mass Spectrometry | 2,005 | D000900:Anti-Bacterial Agents; D006096:Gramicidin |
[Biliary ileus--a rare complication of cholecystolithiasis]. | The diagnosis of ileus caused by biliary stones occurs very rarely, with the range of 2 % worldwide. This complication of cholecystolithiasis caused by the stone fistulation into gastrointestinal tract and its subsequent obstruction occurs mostly in elderly and has a high mortality rate. During the course of ten years ... | 18,064,790 | D000369:Aged, 80 and over; D001658:Biliary Fistula; D041761:Cholecystolithiasis; D004378:Duodenal Diseases; D005260:Female; D005705:Gallbladder Diseases; D006801:Humans; D007412:Intestinal Fistula; D007415:Intestinal Obstruction; D008875:Middle Aged | Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti | 2,007 | ||
Meat disgust is negatively associated with meat intake - Evidence from a cross-sectional and longitudinal study. | Meat consumption is increasingly seen as unsustainable, unhealthy, and unethical. Understanding what factors help people reduce their meat intake is urgently needed. One such factor is meat disgust, a feeling reported by many vegetarians, and which could be a promising basis for meat reduction interventions. However, m... | 10.1016/j.appet.2021.105299 | 33,965,435 | D000328:Adult; D003430:Cross-Sectional Studies; D014676:Diet, Vegetarian; D000078382:Disgust; D006801:Humans; D008137:Longitudinal Studies; D008460:Meat; D000066988:Vegetarians | Appetite | 2,021 | |
The critical role of ultra-low-energy vibrations in the relaxation dynamics of molecular qubits. | Improving the performance of molecular qubits is a fundamental milestone towards unleashing the power of molecular magnetism in the second quantum revolution. Taming spin relaxation and decoherence due to vibrations is crucial to reach this milestone, but this is hindered by our lack of understanding on the nature of v... | 10.1038/s41467-023-36852-y | 36,964,152 | Nature communications | 2,023 | ||
Early intervention for hearing impairment: differences in the timing of communicative and linguistic development. | This paper reports in-depth case study material which illuminates the impact of early aiding on the rate of acquisition of communicative and linguistic behaviours of a small group of severely and profoundly deaf infants (average better ear impairment of 101 dB) aided between 3 and 6 months of age. A comparison is made ... | 10.3109/03005369509076750 | 8,861,408 | D000367:Age Factors; D002663:Child Language; D002675:Child, Preschool; D005260:Female; D006310:Hearing Aids; D006312:Hearing Loss, Bilateral; D006319:Hearing Loss, Sensorineural; D006801:Humans; D007223:Infant; D007804:Language Development; D008137:Longitudinal Studies; D008297:Male; D013067:Speech Perception | British journal of audiology | 1,995 | |
Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity. | Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging. In the past few years, a number of intelligent molecular imaging probes with fluorescence, magnetic resonance imaging (MRI), positron electron tomography... | 10.1039/d0bm00895h | 32,627,767 | D057054:Molecular Imaging; D015335:Molecular Probes; D049329:Nanostructures; D011446:Prospective Studies | Biomaterials science | 2,021 | D015335:Molecular Probes |
Evaluation of the FlexSure HP whole blood antibody test for diagnosis of Helicobacter pylori infection. | OBJECTIVE
Rapid, inexpensive, reliable tests are needed to facilitate the diagnosis of Helicobacter pylori infection. We evaluated the accuracy of the new FlexSure HP whole blood test (SmithKline Diagnostics, Inc.), a rapid, qualitative in-office test for the detection of antibodies to H. pylori utilizing whole blood o... | 10.1111/j.1572-0241.1998.00604.x | 9,820,383 | D000907:Antibodies, Bacterial; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity | The American journal of gastroenterology | 1,998 | D000907:Antibodies, Bacterial |
Optimising access and provision of interventional radiology service to patients by utilising a new referral system. | OBJECTIVE
Implementing a streamlined interventional radiology (IR) service in the UK has been a challenge. This study aims to review a set of changes introduced in IR at a tertiary centre, including a new referral process and the designation of IR clinical nurse specialists.
METHODS
A new process of referring patient... | 10.1259/bjr.20210727 | 34,591,603 | D006801:Humans; D008505:Medical Staff, Hospital; D009720:Nurse Clinicians; D009741:Nursing Staff, Hospital; D017060:Patient Satisfaction; D015642:Radiology, Interventional; D012017:Referral and Consultation; D062606:Tertiary Care Centers; D006113:United Kingdom | The British journal of radiology | 2,022 | |
Use of the 2nd generation TRAK human assay did not improve prediction of relapse after antithyroid medical therapy of Graves' disease. | OBJECTIVE
Antithyroid drug treatment (ATD) is used world-wide in the treatment of thyrotoxicosis in patients with Graves' disease (GD). The main problem is a relapse rate of 30 to 50% within 2 years after the treatment has stopped. The measurement of thyrotropin receptor antibodies (TRAb) in serum has been used to conf... | 10.1530/eje.0.1460173 | 11,834,425 | D000328:Adult; D000368:Aged; D000818:Animals; D013956:Antithyroid Agents; D001323:Autoantibodies; D005260:Female; D006111:Graves Disease; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating; D008297:Male; D008875:Middle Aged; D011989:Receptors, Thyrotropin; D011994:Recombinant Proteins; D012008:Recurrence; D01... | European journal of endocrinology | 2,002 | D013956:Antithyroid Agents; D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; D011994:Recombinant Proteins; C094372:thyrotropin-binding inhibitory immunoglobulin; D014284:Triiodothyronine; D013974:Thyroxine |
Biogenesis of sesquiterpene lactones pseudoguaianolides from germacranolides: theoretical study on the reaction mechanism of terminal biogenesis of 8-epiconfertin. | The fundamental study of the biogenetic origin of natural products has always been limited from the experimental point of view because proposed reaction mechanisms have only been supported on the molecular structures of reagents and the reaction products. In a seminal contribution, Ortega and Maldonado (Ortega, A.; Mal... | 10.1021/jo802445n | 19,055,363 | D002244:Carbon; D003198:Computer Simulation; D007783:Lactones; D008956:Models, Chemical; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; D013816:Thermodynamics | The Journal of organic chemistry | 2,009 | D007783:Lactones; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C432449:germacranolide; C012259:confertin; D002244:Carbon |
Lipids in Neurodegenerative Diseases. | Lipids are undoubtedly the major constituents of the cell membranes of all living organisms, and the most efficient source of energy [...]. | 10.3390/ijms241411523 | 37,511,282 | D006801:Humans; D019636:Neurodegenerative Diseases; D002462:Cell Membrane; D008055:Lipids | International journal of molecular sciences | 2,023 | D008055:Lipids |
Expression and properties of three novel fungal lipases/sterol esterases predicted in silico: comparison with other enzymes of the Candida rugosa-like family. | Lipases from the Candida rugosa-like family are enzymes with great biotechnological interest. In a previous work, several enzymes from this family were identified by in silico mining of fungal genomes. Here, we describe the cloning, expression, and characterization of putative lipases from the genomes of Nectria haemat... | 10.1007/s00253-015-6890-9 | 26,272,094 | D001234:Aspergillus niger; D003001:Cloning, Molecular; D019295:Computational Biology; D005670:Fusarium; D015870:Gene Expression; D006868:Hydrolysis; D007700:Kinetics; D008049:Lipase; D055156:Ophiostoma; D002787:Sterol Esterase; D013379:Substrate Specificity; D014242:Trichoderma | Applied microbiology and biotechnology | 2,015 | D002787:Sterol Esterase; D008049:Lipase |
Chemical, experimental, and clinical studies on endogenous ouabain-like substance in hypertension. | A heat-stable, low molecular weight, anionic substance(s) capable of inhibiting 3H-ouabain binding and Na+-K+-ATPase activity could be extracted from human urine and plasma. The level of the inhibitor was elevated in 40%-50% of essential hypertensives, compared to controls, and also in some of the offspring of hyperten... | 2,579,533 | D000328:Adult; D000368:Aged; D000818:Animals; D001792:Blood Platelets; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension; D007473:Ion Channels; D007668:Kidney; D008297:Male; D008875:Middle Aged; D010042:Ouabain; D011188:Potassium; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin;... | Advances in nephrology from the Necker Hospital | 1,985 | D007473:Ion Channels; D012701:Serotonin; D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium | |
Propofol or thiopentone: effects on intraocular pressure associated with induction of anaesthesia and tracheal intubation (facilitated with suxamethonium). | Changes in intraocular pressure (IOP) were studied in patients given propofol 2.1 mg kg-1 (n = 30) or thiopentone 4.9 mg kg-1 (n = 30) followed by suxamethonium 1.0 mg kg-1 and tracheal intubation. Half the patients in each group received an additional smaller dose of the same induction agent (propofol 1.0 mg kg-1 or t... | 10.1093/bja/59.4.431 | 3,494,468 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous; D000777:Anesthetics; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D007429:Intraocular Pressure; D007442:Intubation, Intratracheal; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; ... | British journal of anaesthesia | 1,987 | D000777:Anesthetics; D010636:Phenols; D013390:Succinylcholine; D013874:Thiopental; D015742:Propofol |
[A girl with a painful hip after a splits]. | A 14-year-old girl had a painful hip after making a splits on a trampoline. On X-ray we discovered an avulsion fracture of the spina iliaca anterior superior, which healed in 6 weeks with conservative treatment. | 22,617,064 | D000293:Adolescent; D001265:Athletic Injuries; D005260:Female; D006617:Hip Dislocation; D006620:Hip Fractures; D006801:Humans; D007085:Ilium; D011859:Radiography | Nederlands tijdschrift voor geneeskunde | 2,012 | ||
[Microbiological and resistance profiles of community acquired and nosocomial intra abdominal infections in surgery of National Hospital Guillermo Almenara, Lima, Peru]. | OBJECTIVE
To determine the microbiological and resistance profiles of community acquired and nosocomial intra abdominal infections (IAIs) at the Surgery Service of Emergency and surgery critical care units from the Hospital Nacional Guillermo Almenara Irigoyen.
MATERIAL AND METHODS
From August 1st, 2013 till July 31s... | 27,409,087 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D003131:Combined Modality Therapy; D017714:Community-Acquired Infections; D003428:Cross Infection; D004322:Drainage; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria; D016905:Gram... | Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru | 2,016 | D000900:Anti-Bacterial Agents | |
Demonstration of Non-Gaussian Restricted Diffusion in Tumor Cells Using Diffusion Time-Dependent Diffusion-Weighted Magnetic Resonance Imaging Contrast. | The diffusion-weighted magnetic resonance imaging (DWI) technique enables quantification of water mobility for probing microstructural properties of biological tissue and has become an effective tool for collecting information about the underlying pathology of cancerous tissue. Measurements using multiple b-values have... | 10.3389/fonc.2016.00179 | 27,532,028 | Frontiers in oncology | 2,016 | ||
Hypertensive disease, preterm birth, fetal growth restriction and chronic inflammatory disorders of the placenta: experiences in a single institution with a standardized protocol of investigation. | PURPOSE
Chronic inflammatory disorders of the placenta, in particular villitis of unknown etiology (VUE), chronic deciduitis (CD), chronic chorioamnionitis (CC), chronic histiocytic intervillositis (CHI), and eosinophilic/T-cell chorionic vasculitis (ETCV) can exclusively be diagnosed histologically. Using a standardiz... | 10.1007/s00404-021-06293-3 | 34,693,459 | D002908:Chronic Disease; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation; D006801:Humans; D006973:Hypertension; D007231:Infant, Newborn; D007249:Inflammation; D010920:Placenta; D010922:Placenta Diseases; D011247:Pregnancy; D047928:Premature Birth; D012196:Review Literature as Topic | Archives of gynecology and obstetrics | 2,022 | |
Penicillin-nonsusceptible pneumococcus in acute otitis media in New York City. | OBJECTIVE
To determine the proportion of children with acute otitis media (AOM) presenting in our catchment area in New York City who were infected with nonsusceptible Streptococcus pneumoniae and to determine the susceptibility of these organisms to penicillins and other antibiotics commonly used to treat AOM.
SETTI... | 10.1016/S0194-5998(99)70118-X | 10,388,872 | D000208:Acute Disease; D002439:Cefotaxime; D002511:Cephalosporins; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D009519:New York City; D010033:Otitis Media; D010406:Penicillins; D013296:Streptococcus pneumoniae | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 1,999 | D002511:Cephalosporins; D010406:Penicillins; D002439:Cefotaxime |
De novo donor-specific anti-HLA antibodies after kidney transplantation are associated with impaired graft outcome independently of their C1q-binding ability. | Many aspects of post-transplant monitoring of donor-specific (DSA) and non-donor-specific (nDSA) anti-HLA antibodies on renal allograft survival are still unclear. Differentiating them by their ability to bind C1q may offer a better risk assessment. We retrospectively investigated the clinical relevance of de novo C1q-... | 10.1111/tri.12887 | 27,862,352 | D000328:Adult; D000368:Aged; D000906:Antibodies; D001706:Biopsy; D015922:Complement C1q; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006680:HLA Antigens; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency; D012189:Retrospective Studies; D... | Transplant international : official journal of the European Society for Organ Transplantation | 2,017 | D000906:Antibodies; D006680:HLA Antigens; D015922:Complement C1q |
Benoxacor induction of terbuthylazine detoxification in Zea mays and Festuca arundinacea. | The action of safener benoxacor on the detoxification of terbuthylazine (TBA) in Zea mays and Festuca arundinacea was ascertained by the investigation of the effects of benoxacor on the activity of glutathione-S-transferases (GSTs) in the shoots of the two plant species. TBA treatment generally reduced GST activity tow... | 10.1021/jf047948n | 15,796,583 | D004591:Electrophoresis, Polyacrylamide Gel; D031751:Festuca; D005982:Glutathione Transferase; D006540:Herbicides; D007700:Kinetics; D010078:Oxazines; D018520:Plant Shoots; D014227:Triazines; D003313:Zea mays | Journal of agricultural and food chemistry | 2,005 | D006540:Herbicides; D010078:Oxazines; D014227:Triazines; D005982:Glutathione Transferase; C037565:terbutylazine; C085163:benoxacor |
Invasive thymomas: diagnosis and evaluation by computed tomography. | Ten cases of invasive thymoma examined by computed tomography (CT) and by conventional chest roentgenography are reviewed. In each case, CT showed at least one significant abnormality that was not disclosed by conventional techniques. Computed tomography was especially effective in detecting pleural implants above the ... | 7,069,019 | D003964:Diaphragm; D005260:Female; D006338:Heart Neoplasms; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010496:Pericardium; D010997:Pleural Neoplasms; D012186:Retroperitoneal Neoplasms; D013945:Thymoma; D013953:Thymus Neoplasms; D014057:Tomography, X... | Journal of computer assisted tomography | 1,982 | ||
The Effect of Educational Intervention on the Patient's Willingness to Carry out the Immunochemical Faecal Occult Blood Test for Colorectal Cancer. | BACKGROUND
There is now compelling evidence that screening for colorectal cancer may result in significantly reduced mortality. Screening tests for colorectal cancer are not systematically performed in Bulgaria.
AIM
This article explores the effect of an educational intervention on the willingness of patients to part... | 10.1515/sjph-2015-0032 | 27,646,731 | Zdravstveno varstvo | 2,015 | ||
A proteomic approach to identifying proteins differentially expressed in conidia and mycelium of the entomopathogenic fungus Metarhizium acridum. | Metarhizium spp. is an important worldwide group of entomopathogenic fungi used as an interesting alternative to chemical insecticides in programs of agricultural pest and disease vector control. Metarhizium conidia are important in fungal propagation and also are responsible for host infection. Despite their importanc... | 10.1016/j.funbio.2010.04.007 | 20,943,168 | D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional; D005656:Fungal Proteins; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006110:Grasshoppers; D052981:Metarhizium; D008969:Molecular Sequence Data; D025282:Mycelium; D040901:Proteomics; D013045:Species Specificity; D... | Fungal biology | 2,010 | D005656:Fungal Proteins |
A comparative analysis of mono- and disaccharide benzyl fucopyranosides. | The syntheses and X-ray analyses of two fucopyranosides, the monosaccharide benzyl 3,4-di-O-acetyl-2-hydroxy-beta-D-fucopyranoside, C(17)H(22)O(7), and the disaccharide 1-benzyl O-(2,3-di-O-acetyl-4,6-O-benzylidene-beta-D-glucopyranosyl)-(1-->2)-3,4-O-isopropylidene-beta-D-fucopyranoside, C(33)H(40)O(12), are described... | 10.1107/S0108270102012556 | 12,205,380 | D002236:Carbohydrate Conformation; D002241:Carbohydrates; D008958:Models, Molecular | Acta crystallographica. Section C, Crystal structure communications | 2,002 | D002241:Carbohydrates |
Epidemiology, clinical features and treatment outcome of Wilms' tumor in Taiwan: a report from Taiwan Pediatric Oncology Group. | BACKGROUND AND PURPOSE
Taiwan Pediatric Oncology Group (TPOG)-W-91 is the first multi-institutional Wilms' tumor study for children in Taiwan. This clinical trial used a multidisciplinary approach, based on and similar to the National Wilms' Tumor Study 4. The study was conducted to evaluate the epidemiological charact... | 15,083,240 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms; D008297:Male; D016016:Proportional Hazards Models; D016019:Survival Analysis; D013624:Taiwan; D016896:Trea... | Journal of the Formosan Medical Association = Taiwan yi zhi | 2,004 | ||
Elastic retrograde intramedullary percutaneous pinning for fifth metacarpal neck fractures: A series of 32 patients. | The aim of our study was to evaluate an original surgical technique for the treatment of fifth metacarpal neck fractures: elastic retrograde intramedullary percutaneous pinning (ERIPP). From January 2014 to January 2016, patients with a fifth metacarpal neck fracture with greater than 30° volar displacement and/or clin... | 10.1016/j.hansur.2017.04.004 | 28,551,317 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001864:Bone Wires; D004185:Disability Evaluation; D005594:Fracture Fixation, Intramedullary; D017102:Fracture Healing; D050723:Fractures, Bone; D018737:Hand Strength; D006801:Humans; D050279:Metacarpal Bones; D008875:Middle Aged; D055815:Young Adult | Hand surgery & rehabilitation | 2,017 | |
Simultaneous determination of pseudoephedrine hydrochloride and diphenhydramine hydrochloride in cough syrup by gas chromatography (GC). | A simple, rapid and precise gas chromatographic method has been developed for the simultaneous determination of pseudoephedrine hydrochloride and diphenhydramine hydrochloride in cough syrup, using a SS column of 10% OV 1 on chromosorb W-HP (80-100 mesh) and nitrogen as a carrier gas at a flow rate of 30 ml min(-1). Th... | 10.1016/s0039-9140(97)00277-4 | 18,967,146 | Talanta | 1,998 | ||
Importance of QT/RR hysteresis correction in studies of drug-induced QTc interval changes. | QT/RR hysteresis and QT/RR adaptation are interlinked but separate physiological processes signifying how quickly and how much QT interval changes when heart rate changes, respectively. While QT interval duration is, as a rule, corrected for heart rate in terms of the QT/RR adaptation, the correction for QT/RR hysteres... | 10.1007/s10928-018-9587-8 | 29,651,591 | D064420:Drug-Related Side Effects and Adverse Reactions; D004562:Electrocardiography; D006321:Heart; D006339:Heart Rate; D006801:Humans; D004364:Pharmaceutical Preparations | Journal of pharmacokinetics and pharmacodynamics | 2,018 | D004364:Pharmaceutical Preparations |
Spectrum of antibacterial activity and mode of action of a novel tris-stilbene bacteriostatic compound. | The spectrum of activity and mode of action of a novel antibacterial agent, 135C, was investigated using a range of microbiological and genomic approaches. Compound 135C was active against Gram-positive bacteria with MICs for Staphylococcus aureus ranging from 0.12-0.5 μg/ml. It was largely inactive against Gram-negati... | 10.1038/s41598-018-25080-w | 29,720,673 | D000900:Anti-Bacterial Agents; D004305:Dose-Response Relationship, Drug; D016680:Genome, Bacterial; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009154:Mutation; D013267:Stilbenes | Scientific reports | 2,018 | D000900:Anti-Bacterial Agents; D013267:Stilbenes |
The psychosocial outcome of adolescent-onset schizophrenia: a 12-year followup. | This study examines the educational/occupational outcome and social situation of patients treated for schizophrenia in adolescence (age at admission 11.5-17.9 years; mean 16.0 years). Out of 96 consecutively admitted patients between 1976 and 1987, 85 (89%) could be traced and 65 (68%) were reassessed more than 10 year... | 10.1093/oxfordjournals.schbul.a033495 | 11,087,013 | D000208:Acute Disease; D000293:Adolescent; D017668:Age of Onset; D002648:Child; D015986:Confounding Factors, Epidemiologic; D004522:Educational Status; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008297:Male; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factor... | Schizophrenia bulletin | 2,000 | |
Relationships of Inflammatory Factors and Risk Factors with Different Target Organ Damage in Essential Hypertension Patients. | BACKGROUND
Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its c... | 10.4103/0366-6999.206343 | 28,524,828 | D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000368:Aged; D000959:Antihypertensive Agents; D004797:Enzyme-Linked Immunosorbent Assay; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D051436:Renal Insuffic... | Chinese medical journal | 2,017 | D000959:Antihypertensive Agents; D000685:Serum Amyloid A Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D053802:Tryptases |
High-intensity focused ultrasound combined with hysteroscopic resection for the treatment of placenta accreta. | OBJECTIVE
The aim of this study was to evaluate the safety and efficacy of a combination of high-intensity focused ultrasound (HIFU) and hysteroscopic resection while treating placenta accreta (PA).
DESIGN
A retrospective study.
SETTING
A university teaching hospital in China.
METHODS
This study included 25 patie... | 10.1111/1471-0528.14743 | 28,856,861 | D000328:Adult; D002585:Cesarean Section; D005260:Female; D005500:Follow-Up Studies; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D015907:Hysteroscopy; D007902:Length of Stay; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D010298:Parity; D010920:Placenta; D010921:Placenta Accreta; D01124... | BJOG : an international journal of obstetrics and gynaecology | 2,017 | |
Levosimendan improves exercise performance in patients with advanced chronic heart failure. | AIMS
Cardiopulmonary exercise test (CPET) provides parameters such as peak VO2 and ventilation/CO2 production (VE/VCO2) slope, which are strong prognostic predictors in patients with stable advanced chronic heart failure (ADHF). The study aim was to evaluate the effects of the inodilator levosimendan on CPET in patient... | 10.1002/ehf2.12047 | 27,708,855 | ESC heart failure | 2,015 | ||
Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond. | Biochemical and molecular imaging of cancer using positron emission tomography (PET) plays an increasing role in the care of cancer patients. Most clinical work to date uses the glucose analogue [(18)F]fluorodeoxyglucose (FDG) to detect accelerated and aberrant glycolysis present in most tumors. Although clinical FDG P... | 10.1158/1078-0432.CCR-07-0074 | 17,575,208 | D000818:Animals; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009369:Neoplasms; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals | Clinical cancer research : an official journal of the American Association for Cancer Research | 2,007 | D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18 |
[Transanal lateral lymph node dissection surgery for 5 cases of mid-low rectal cancer]. | Objective: To evaluate the feasibility and safety of transanal lateral lymph node dissection for mid-low rectal cancer. Methods: A descriptive case series research method was used. Clinical and pathological data of 5 mid-low rectal cancer patients who underwent transanal lateral lymph node dissection at Department of C... | 10.3760/cma.j.issn.1671-0274.2019.08.014 | 31,422,618 | D000230:Adenocarcinoma; D000328:Adult; D001003:Anal Canal; D000714:Anastomosis, Surgical; D003106:Colon; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008297:Male; D008643:Mesentery; D008875:Middle Aged; D009367:Neoplasm Staging; D00... | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | 2,019 | |
Active Surveillance in Adults with Low-Risk Papillary Thyroid Microcarcinomas: A Prospective Study. | The acceptance and results of active surveillance in patients with low-risk papillary thyroid microcarcinomas (PTMC) are unknown in populations other than the Japanese population. This was the objective of the present prospective study. We selected patients ≥20 years who had thyroid nodules ≤1.2 cm with intermediate or... | 10.1055/a-1015-6684 | 31,683,339 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013964:Thyroid Neoplasms; D016606:Th... | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme | 2,019 | |
Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. | To investigate a possible association between vitamin D receptor genotype and development of postmenopausal osteoporosis, a longitudinal study from 1977 to 1995 was carried out on women living in Oslo, Norway. One hundred and eighteen premenopausal women born in 1930 were included in a study of pre- and postmenopausal ... | 10.1530/eje.0.1350096 | 8,765,980 | D000368:Aged; D015519:Bone Density; D015331:Cohort Studies; D005260:Female; D050723:Fractures, Bone; D005838:Genotype; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal; D017698:Postmenopause; D018167:Receptors, Calcitriol | European journal of endocrinology | 1,996 | D018167:Receptors, Calcitriol |
Hydrophobic-ionic chromatography. Its application to purification of porcine pancreas enzymes. | 1. All the porcine pancreas enzymes tested, regardless of their pI's were adsorbed on Amberlite CG-50 (a weakly acidic cation exchange resin) at pH 4, where the ion-exchange group (carboxyl group) is not dissociated. The adsorption is hardly influenced by ionic strength. 2. At pH 4, the adsorbed enzymes were partially ... | 10.1093/oxfordjournals.jbchem.a132671 | 316,432 | D000681:Amylases; D000818:Animals; D002268:Carboxypeptidases; D002852:Chromatography, Ion Exchange; D003851:Deoxyribonucleases; D007610:Kallikreins; D008049:Lipase; D010179:Pancreas; D012997:Solvents; D013552:Swine; D014357:Trypsin; D000516:alpha-Amylases | Journal of biochemistry | 1,979 | D012997:Solvents; D003851:Deoxyribonucleases; D008049:Lipase; D000681:Amylases; D000516:alpha-Amylases; D002268:Carboxypeptidases; D007610:Kallikreins; D014357:Trypsin |
Viscosity Landscape of Phase-Separated Lipid Membrane Estimated from Fluid Velocity Field. | In cell membranes, the functional constituents such as peptides, proteins, and polysaccharides diffuse in a sea of lipids as single molecules and molecular aggregates. Thus, the fluidity of the heterogeneous multicomponent membrane is important for understanding the roles of the membrane in cell functionality. Recently... | 10.1016/j.bpj.2020.01.009 | 32,053,773 | D002462:Cell Membrane; D002784:Cholesterol; D004058:Diffusion; D008051:Lipid Bilayers; D008055:Lipids; D010713:Phosphatidylcholines; D014783:Viscosity | Biophysical journal | 2,020 | D008051:Lipid Bilayers; D008055:Lipids; D010713:Phosphatidylcholines; D002784:Cholesterol |
Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa. | INTRODUCTION
The rapid clearance of factor IX necessitates frequent intravenous administrations to achieve effective prophylaxis for patients with hemophilia B. Subcutaneous administration has historically been limited by low bioavailability and potency. Dalcinonacog alfa was developed using a rational design approach ... | 10.1371/journal.pone.0240896 | 33,112,889 | D000818:Animals; D001682:Biological Availability; D004195:Disease Models, Animal; D004285:Dogs; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005164:Factor IX; D005260:Female; D002836:Hemophilia B; D007279:Injections, Subcutaneous; D008297:Male; D008958:Models, Molecular; D010314:Partial Thromboplastin Ti... | PloS one | 2,020 | D005164:Factor IX |
miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells. | Short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fiber exert myriad of beneficial effects including the amelioration of inflammation. SCFAs exist as anions at luminal pH; their entry into the cells depends on the expression and function of monocarboxylate transporters. In this regard, sodiu... | 10.1152/ajpgi.00148.2021 | 34,231,393 | D018938:Caco-2 Cells; D006801:Humans; D007413:Intestinal Mucosa; D035683:MicroRNAs; D027501:Monocarboxylic Acid Transporters | American journal of physiology. Gastrointestinal and liver physiology | 2,021 | C532045:MIRN29a microRNA, human; D035683:MicroRNAs; D027501:Monocarboxylic Acid Transporters; C476760:SLC5A8 protein, human |
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. | Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase (LH), hydroxylysyl galactosyltransferase (GT) and galactosylhydroxylysyl glucosyltransferase (GGT) activities in vitro. To investigate the in vivo importance of LH3-catalyzed lysine hydroxylation and hydroxylysine-linked glycosylations, ... | 10.1242/jcs.02780 | 16,467,571 | D000818:Animals; D001485:Basement Membrane; D002384:Catalysis; D003094:Collagen; D005700:Galactosyltransferases; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D005964:Glucosyltransferases; D006031:Glycosylation; D006901:Hydroxylysine; D051379:Mice; D018345:Mice, Kno... | Journal of cell science | 2,006 | D006901:Hydroxylysine; D003094:Collagen; C510730:lysyl hydroxylase 3, mouse; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; D005700:Galactosyltransferases; D005964:Glucosyltransferases; C023236:UDPgalactose-collagen galactosyltransferase; C023247:UDP glucose-collagen glucosyltransferase |
Investigation of an Alternative Marker for Hypermutability Evaluation in Different Tumors. | A growing number of studies have shown immunotherapy to be a promising treatment strategy for several types of cancer. Short tandem repeats (STRs) have been proven to be alternative markers for the evaluation of hypermutability in gastrointestinal (GI) cancers. However, the status of STRs and microsatellite instability... | 10.3390/genes12020197 | 33,572,856 | D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D002292:Carcinoma, Renal Cell; D015179:Colorectal Neoplasms; D004273:DNA, Neoplasm; D004938:Esophageal Neoplasms; D005260:Female; D016368:Frameshift Mutation; D006801:Humans; D008113:Liver Neoplasms; D008175:Lung Neoplasms; D053842:Microsatellite Instability; D018895... | Genes | 2,021 | D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm |
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