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[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists. | This letter describes the discovery, synthesis, SAR, and biological activity of [2.2.1]-bicyclic sultams as potent antagonists of the androgen receptor. Optimization of the series led to the identification of compound 25, which displayed robust pharmacodynamic effects in rats after oral dosing. | 10.1016/j.bmcl.2016.10.059 | 27,836,399 | D000284:Administration, Oral; D059002:Androgen Receptor Antagonists; D000818:Animals; D001643:Bridged Bicyclo Compounds; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D009282:Naphthalenesulfonates; D051381:Rats; D011944:Receptors, Androgen; D013329:Structure-Activity Relationship | Bioorganic & medicinal chemistry letters | 2,016 | D059002:Androgen Receptor Antagonists; D001643:Bridged Bicyclo Compounds; D009282:Naphthalenesulfonates; D011944:Receptors, Androgen; C016768:naphthosultone |
Involvement of epidermal growth factor (EGF)/EGF receptor autocrine and paracrine mechanism in human trophoblast cells: functional differentiation in vitro. | We have studied the expression of epidermal growth factor (EGF) and EGF receptors (EGF-R) in isolated human trophoblast cells at various stages of differentiation and also the biological significance of the EGF/EGF-R autocrine and paracrine mechanism. Cytotrophoblast cells were isolated from human placental tissues of ... | 10.1677/joe.0.1430291 | 7,530,287 | D001483:Base Sequence; D002454:Cell Differentiation; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D017931:DNA Primers; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular... | The Journal of endocrinology | 1,994 | D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D017931:DNA Primers; D010446:Peptide Fragments; D004815:Epidermal Growth Factor; D010928:Placental Lactogen; D066246:ErbB Receptors |
Efficacy of multi-stage sous-vide cooking on tenderness of low value beef muscles. | The efficacy of thermal activation of residual proteolytic enzymes on shear force and deformation of 72 beef supraspinatus (SS) and rectus femoris (RF) muscles was tested using multi-stage sous-vide cooking (M-SV; 1 h at 39 °C, 1 h at 49 °C, 4 h at 59 °C), single-stage sous-vide cooking (S-SV; 4 h at 59 °C), and waterb... | 10.1016/j.meatsci.2018.11.008 | 30,453,279 | D000818:Animals; D002417:Cattle; D003296:Cooking; D061353:Food Storage; D018482:Muscle, Skeletal; D010447:Peptide Hydrolases; D000069466:Red Meat; D033081:Shear Strength; D013696:Temperature | Meat science | 2,019 | D010447:Peptide Hydrolases |
Sagittal Alignment in Patients with Thoracic Myelopathy Caused by the Ossification of the Ligamentum Flavum: A Retrospective Matched Case-Control Study. | STUDY DESIGN
Retrospective case-control study.
OBJECTIVE
The aim of this study was to describe and compare the sagittal spinal alignment between patients with and without the ossification of the ligamentum flavum in the thoracic spine (TOLF).
SUMMARY OF BACKGROUND DATA
Although mechanical factors play an important ... | 10.1097/BRS.0000000000003791 | 33,534,440 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D017843:Ligamentum Flavum; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic; D012189:Retrospective Studies; D013118:Spinal Cord Diseases; D013904:Tho... | Spine | 2,021 | |
Health promotion through structured oral hygiene and good tooth alignment. | Aim
Periodontal diseases and caries are two of the most common forms of chronic degenerative diseases, with consequences not only for the oral cavity manifesting as tooth loss, orofacial pain and xerostomia, but also with effects on the cardiovascular system and, in the elderly, on the pneumonia rate. This can be preve... | 10.3205/dgkh000411 | 35,707,231 | GMS hygiene and infection control | 2,022 | ||
Association of glucocorticoid receptor polymorphism A3669G with decreased risk of developing diabetes in patients with Cushing's syndrome. | OBJECTIVE
Glucocorticoid receptor (GR) polymorphisms alter glucocorticoid (GC) sensitivity and have been associated with altered metabolic profiles. We evaluate the prevalence of the four GR (NR3C1) polymorphisms BclI, N363S, ER22/23EK, and A3669G in patients with Cushing's syndrome (CS) compared with healthy controls ... | 10.1530/EJE-11-0722 | 22,048,965 | D000328:Adult; D003480:Cushing Syndrome; D003920:Diabetes Mellitus; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011965:Receptors, Glucocorticoid | European journal of endocrinology | 2,012 | D011965:Receptors, Glucocorticoid |
The problems with contact-tracing apps. | As countries look to ease restrictions and manage second waves of cases, apps are appealing but fraught with issues, reports Adam Vaughan. | 10.1016/S0262-4079(20)30787-9 | 32,372,819 | New scientist (1971) | 2,020 | ||
Evaluation in Ayres Sensory Integration® Praxis Tests: Construct Validity and Internal Reliability. | IMPORTANCE
Assessment of praxis using valid and reliable measures is important for understanding factors affecting occupational participation.
OBJECTIVE
To evaluate evidence of construct validity and internal reliability of data gathered with four newly developed praxis tests.
DESIGN
Comparative descriptive design.... | 10.5014/ajot.2023.050138 | 37,589,659 | D002648:Child; D006801:Humans; D015203:Reproducibility of Results; D009788:Occupational Therapy; D012574:Schools | The American journal of occupational therapy : official publication of the American Occupational Therapy Association | 2,023 | |
Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow? | Attention deficit/hyperactivity disorder (ADHD) is one of the most frequent behavioral problems in school-age children. Although the etiology remains unclear, the involvement of the dopaminergic system has been suggested by genetic studies that report an overexpression of the dopamine transporter (DAT) gene. In spite o... | 10.1097/RLU.0b013e318219b49d | 21,716,015 | D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity; D001479:Basal Ganglia; D002560:Cerebrovascular Circulation; D003545:Cysteine; D004298:Dopamine; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D008297:Male; D017072:Neostriatum; D015609:Organotechnetium Compounds; D015899:T... | Clinical nuclear medicine | 2,011 | D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; C059659:technetium Tc 99m bicisate; D003545:Cysteine; D004298:Dopamine |
The ultimate straight line repair for unilateral cleft lips. | The straight line repair for unilateral cleft lips developed following the negative long term objective and subjective findings in a group of patients whose defects were repaired using the Millard technique. No revisional surgery had been undertaken. The straight line procedure achieves the aims of a cleft lip repair. ... | 10.1016/j.bjps.2007.10.017 | 18,023,632 | D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix; D002971:Cleft Lip; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008046:Lip; D008297:Male; D019651:Plastic Surgery Procedures; D016896:Treatment Outcome; D0... | Journal of plastic, reconstructive & aesthetic surgery : JPRAS | 2,009 | |
Russian nurses' readiness for transcultural care of palliative patients. | Palliative care involves an approach aimed at improving the quality of life of patients and their families, who are forced to cope with the problems associated with life-threatening diseases. This definition includes a growing group of patients around the world. It requires an extension of the definition of patients in... | 10.1186/s12904-023-01198-1 | 37,407,991 | D006801:Humans; D002675:Child, Preschool; D002648:Child; D000293:Adolescent; D011788:Quality of Life; D010166:Palliative Care; D006738:Hospices; D012426:Russia; D009726:Nurses | BMC palliative care | 2,023 | |
Evaluating the Effects of Metal Adduction and Charge Isomerism on Ion-Mobility Measurements using m-Xylene Macrocycles as Models. | Gas-phase ion-mobility spectrometry provides a unique platform to study the effect of mobile charge(s) or charge location on collisional cross section and ion separation. Here, we evaluate the effects of cation/anion adduction in a series of xylene and pyridyl macrocycles that contain ureas and thioureas. We explore ho... | 10.1021/jasms.2c00033 | 35,471,025 | D000838:Anions; D006371:Helium; D007536:Isomerism; D008670:Metals; D009584:Nitrogen; D011522:Protons; D014992:Xylenes; D015032:Zinc | Journal of the American Society for Mass Spectrometry | 2,022 | D000838:Anions; D008670:Metals; D011522:Protons; D014992:Xylenes; D006371:Helium; D015032:Zinc; D009584:Nitrogen; C031285:3-xylene |
Evaluation of safety and efficacy of azithromycin in lower respiratory tract infections (LRTI) | Azithromycin was given to 55 cases of lower respiratory tract infections in the doses of 500 mg on day 1, followed by 250 mg on days 2-5. It produced bacteriological cure in 70.8% patients and clinical cure or improvement in 69.09% of patients. 4.27% of patients had throat colonisation with new organisms, of which 9.09... | 9,057,364 | D000293:Adolescent; D000900:Anti-Bacterial Agents; D017963:Azithromycin; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D012141:Respiratory Tract Infections; D016896:Treatment Outcome | Indian journal of medical sciences | 1,996 | D000900:Anti-Bacterial Agents; D017963:Azithromycin | |
Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase. | Through large-scale sequencing of clones randomly selected from a library of human cDNAs, we have isolated a novel human gene termed hUQCR10. Its open reading frame encodes 63 amino acids that share 88.5% identity with the sequence of bovine ubiquinol-cytochrome C reductase 7.2-kDa protein (subunit X). A single 0.6-kb ... | 10.1007/s100380050008 | 10,697,962 | D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003593:Cytoplasm; D018076:DNA, Complementary; D014450:Electron Transport Complex III; D006801:Humans; D008928:Mitochondria; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid | Journal of human genetics | 2,000 | D018076:DNA, Complementary; D014450:Electron Transport Complex III |
The management of glottic and supraglottic cancers of the larynx in relation to neck metastasis. | OBJECTIVES
We evaluated the management of glottic and supraglottic laryngeal cancers in relation to neck metastasis.
PATIENTS AND METHODS
Fifty-two patients (51 males, 1 female; mean age 59.2 years; range 27 to 82 years) underwent surgery for primary laryngeal cancers. Preoperative and postoperative TNM classificatio... | 15,542,939 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms; D007825:Laryngectomy; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Ne... | Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat | 2,003 | ||
Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants. | BACKGROUND
Infants born preterm are at increased risk of developing cognitive and motor impairment compared with infants born at term. Early developmental interventions have been provided in the clinical setting with the aim of improving overall functional outcomes for these infants. Long-term benefits of these program... | 10.1002/14651858.CD005495.pub4 | 26,597,166 | D001724:Birth Weight; D002547:Cerebral Palsy; D003072:Cognition Disorders; D018479:Early Intervention, Educational; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D019957:Motor Skills Disorders; D009069:Movement Disorders; D010351:Patien... | The Cochrane database of systematic reviews | 2,015 | |
Burnout syndrome during residency in internal medicine and pediatrics in a country without working time directive. | PURPOSE
The purpose of this paper is to demonstrate burnout syndrome among internal medicine and pediatrics residents in a country that does not have the working time directive (WTD) and also to determine the risk factors and consequent impact on efficient functioning in clinical areas.
DESIGN/METHODOLOGY/APPROACH
A ... | 10.1108/IJHCQA-12-2012-0127 | 25,786,186 | D000328:Adult; D002055:Burnout, Professional; D005260:Female; D006801:Humans; D007388:Internal Medicine; D007396:Internship and Residency; D008297:Male; D010372:Pediatrics; D011795:Surveys and Questionnaires; D014421:Turkey; D016526:Workload; D055815:Young Adult | International journal of health care quality assurance | 2,014 | |
Role of osmoregulation in the actions of taurine. | Taurine regulates an unusual number of biological phenomena, including heart rhythm, contractile function, blood pressure, platelet aggregation, neuronal excitability, body temperature, learning, motor behavior, food consumption, eye sight, sperm motility, cell proliferation and viability, energy metabolism and bile ac... | 10.1007/s007260070004 | 11,140,357 | D000818:Animals; D006801:Humans; D010766:Phosphorylation; D015398:Signal Transduction; D013654:Taurine; D014882:Water-Electrolyte Balance | Amino acids | 2,000 | D013654:Taurine |
R-spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β-catenin signaling pathway. | OBJECTIVE
In this study, we measured the expression of R-spondin 2 (RSPO2) in periodontal ligament (PDL) tissue and cells. Further, we examined the effects of RSPO2 on osteoblastic differentiation of immature human PDL cells (HPDLCs).
BACKGROUND
R-spondin (RSPO) family proteins are secreted glycoproteins that play im... | 10.1111/jre.12611 | 30,284,717 | D000328:Adult; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D005260:Female; D015870:Gene Expression; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010006:Osteoblasts; D010513:Periodontal Ligament; D017207:Rats, Sprague-Dawley; D015398:Signal Transductio... | Journal of periodontal research | 2,019 | D036341:Intercellular Signaling Peptides and Proteins; C557408:Rspo2 protein, human; D051176:beta Catenin |
Phase I trial of homoharringtonine administered by prolonged continuous infusion. | Cephalotaxine alkaloids have been extensively used in the Peoples Republic of China for treatment of acute leukemias and solid tumors (Yu-hua, L., Shu-fen, G., Fu-ying, Z., Shu-zhi, X., and Hui-lin, Z. Chin. Med. J., 96: 303-305, 1983). Several Phase I trials of homoharringtonine have been completed in the United State... | 3,940,656 | D000328:Adult; D000368:Aged; D000470:Alkaloids; D004341:Drug Evaluation; D005260:Female; D006248:Harringtonines; D006410:Hematopoiesis; D000077863:Homoharringtonine; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009369:Neoplasms | Cancer research | 1,986 | D000470:Alkaloids; D006248:Harringtonines; D000077863:Homoharringtonine | |
Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. | The reproductive system of male mice homozygous for a mutation in the estrogen receptor (ER) gene (ER knock-out; ERKO) appears normal at the anatomical level. However, these males are infertile, indicating an essential role for ER-mediated processes in the regulation of male reproduction. Adult ERKO male mice have sign... | 10.1210/endo.137.11.8895349 | 8,895,349 | D000818:Animals; D003307:Copulation; D004822:Epididymis; D004848:Epithelium; D005260:Female; D005640:Follicle Stimulating Hormone; D006579:Heterozygote; D006720:Homozygote; D007248:Infertility, Male; D008098:Litter Size; D007986:Luteinizing Hormone; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, ... | Endocrinology | 1,996 | D011960:Receptors, Estrogen; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone |
Meiotic DNA metabolism in wild-type and excision-deficient yeast following UV exposure. | The effects of UV irradiation on DNA metabolism during meiosis have been examined in wild-type (RAD+) and mitotically defined excision-defective (rad1-1) strains of Saccharomyces cerevisiae that exhibit high levels of sporulation. The rad1-1 gene product is not required for normal meiosis: DNA synthesis, RNA synthesis,... | 10.1093/genetics/104.4.583 | 6,352,404 | D004260:DNA Repair; D004271:DNA, Fungal; D008540:Meiosis; D010641:Phenotype; D012441:Saccharomyces cerevisiae; D014466:Ultraviolet Rays | Genetics | 1,983 | D004271:DNA, Fungal |
Cytokine pattern in blister fluid and sera of patients with pemphigus. | BACKGROUND
Pemphigus is a chronic auto-immune blistering disease with four main variants, i.e. pemphigus vulgaris (PV), foliaceus (PF), erythematosus (PE) and vegetans. The common histological feature of this disease is acantholysis.
OBJECTIVE
The aim of this study was to compare levels of some cytokines in blister f... | 10.1159/000063895 | 12,218,224 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies; D001324:Autoantigens; D001768:Blister; D001826:Body Fluids; D015820:Cadherins; D002648:Child; D016207:Cytokines; D003877:Dermatitis, Contact; D051183:Desmoglein 1; D051184:Desmoglein 3; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D0... | Dermatology (Basel, Switzerland) | 2,002 | D001323:Autoantibodies; D001324:Autoantigens; D015820:Cadherins; D016207:Cytokines; C071894:DSG3 protein, human; D051183:Desmoglein 1; D051184:Desmoglein 3; D016209:Interleukin-8; D016753:Interleukin-10; D007371:Interferon-gamma |
Distal aortic reintervention after surgery for acute DeBakey type I or II aortic dissection: open versus endovascular repair. | OBJECTIVES
Aortic dissection DeBakey type I and II may require distal reinterventions after initial proximal repair. We evaluated outcomes following open versus endovascular approaches to distal aortic pathologies after surgery for acute dissection.
METHODS
One hundred and forty-one consecutive patients underwent 152... | 10.1093/ejcts/ezu488 | 25,527,171 | D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection; D001014:Aortic Aneurysm; D019917:Blood Vessel Prosthesis Implantation; D057510:Endovascular Procedures; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875... | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2,015 | |
BIOGENESIS FACTOR REQUIRED FOR ATP SYNTHASE 3 Facilitates Assembly of the Chloroplast ATP Synthase Complex. | Thylakoid membrane-localized chloroplast ATP synthases use the proton motive force generated by photosynthetic electron transport to produce ATP from ADP. Although it is well known that the chloroplast ATP synthase is composed of more than 20 proteins with α3β3γ1ε1δ1I1II1III14IV1 stoichiometry, its biogenesis process i... | 10.1104/pp.16.00248 | 27,208,269 | D017360:Arabidopsis; D029681:Arabidopsis Proteins; D025222:Chloroplast Proton-Translocating ATPases; D008565:Membrane Proteins; D009154:Mutation; D010641:Phenotype; D010788:Photosynthesis; D011485:Protein Binding; D025941:Protein Interaction Mapping; D021122:Protein Subunits; D020524:Thylakoids | Plant physiology | 2,016 | D029681:Arabidopsis Proteins; D008565:Membrane Proteins; D021122:Protein Subunits; C000622657:biogenesis factor required for ATP synthase 3, Arabidopsis; D025222:Chloroplast Proton-Translocating ATPases |
An Uncommon Complication with a Supraglottic Airway: The King LT. | General anesthesia was administered in an 18-year-old man for removal of hardware from his right knee using a King Laryngeal Tube supraglottic airway. An hour after extubation, he reported inability to swallow with no respiratory distress. Examination showed an edematous uvula, which took 3 days to subside with anti-in... | 10.1213/XAA.0000000000000263 | 26,579,612 | D000293:Adolescent; D000768:Anesthesia, General; D020878:Device Removal; D004487:Edema; D006801:Humans; D007442:Intubation, Intratracheal; D017214:Laryngeal Masks; D008297:Male; D011183:Postoperative Complications; D012119:Respiration; D014609:Uvula | A & A case reports | 2,016 | |
Acute Kidney Injury in Hospitalized Pediatric Patients. | Acute kidney injury (AKI) is pervasive, affecting a significant proportion of critically ill and noncritically ill children. Recent data demonstrate a clear independent association of escalating AKI severity with not only mortality, but also with longer-term disability and chronic kidney disease in children. The paradi... | 10.3928/19382359-20180619-02 | 30,001,443 | D058186:Acute Kidney Injury; D002648:Child; D002673:Child, Hospitalized; D019468:Disease Management; D006801:Humans; D017410:Practice Guidelines as Topic | Pediatric annals | 2,018 | |
Clinical efficacy and safety of two different hematoporphyrin monomethyl ether-mediated photodynamic therapy regimen in Chinese children with port-wine stain. | Hematoporphyrin monomethyl ether-photodynamic therapy (HMME-PDT) has achieved encouraging clinical outcomes in adult port-wine stain (PWS). Optimal treatment option for children with PWS was minimal. To compare whether the clinical effectiveness of HMME-PDT with the 5-min (fast) administration treatment regimen (FATR) ... | 10.1111/exd.14834 | 37,157,235 | D002648:Child; D006801:Humans; D000095225:East Asian People; D018324:Hemangioma, Capillary; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D019339:Port-Wine Stain; D016896:Treatment Outcome | Experimental dermatology | 2,023 | C494379:hematoporphyrin monomethyl ether; D017319:Photosensitizing Agents |
ZmmiR190 and its target regulate plant responses to drought stress through an ABA-dependent pathway. | MicroRNAs (miRNAs) are small, non-coding regulatory RNAs that regulate gene expression by facilitating target mRNA cleavage in plants. They are crucial for responses to diverse stresses. The novel drought-responsive miRNA ZmmiR190 was previously identified during an analysis of the maize transcriptome. In this study, w... | 10.1016/j.plantsci.2021.111034 | 34,620,438 | D000040:Abscisic Acid; D017360:Arabidopsis; D018556:Crops, Agricultural; D055864:Droughts; D018506:Gene Expression Regulation, Plant; D014644:Genetic Variation; D005838:Genotype; D035683:MicroRNAs; D012275:Oryza; D030821:Plants, Genetically Modified; D013312:Stress, Physiological; D014157:Transcription Factors; D003313... | Plant science : an international journal of experimental plant biology | 2,021 | D035683:MicroRNAs; D014157:Transcription Factors; D000040:Abscisic Acid |
Risk factors for soft tissue sarcomas in childhood: a case-control study. | A hospital-based case-control study on soft tissue sarcomas (STS) was conducted in 1983-84 in Torino and in Padova (Italy). Cases (36 children with rhabdomyosarcoma (RMS) and 16 non RMS-STS) were compared to 326 controls. Histories of parental smoking habits and occupations, parental and children's exposure to ionizing... | 10.1177/030089168907500418 | 2,815,346 | D016022:Case-Control Studies; D006801:Humans; D008423:Maternal Age; D012208:Rhabdomyosarcoma; D012307:Risk Factors; D012509:Sarcoma; D012907:Smoking; D012959:Socioeconomic Factors; D012983:Soft Tissue Neoplasms | Tumori | 1,989 | |
The systematic serology of Neisseria gonorrhoeae: antigens associated with pathogenesis in Neisseria spp. from man. | Sonicates of eight Neisseria species from man were analysed in a micro-Ouchterlony double-diffusion absorption assay in comparison with a gonococcal reference antiserum-antigen system. Five major gonococcal precipitin zones were identified which comprised genus-, species- and type-specific components. One antigen was f... | 10.1099/00222615-18-3-347 | 6,209,399 | D000942:Antigens, Bacterial; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D005779:Immunodiffusion; D009343:Neisseria; D009344:Neisseria gonorrhoeae; D009345:Neisseria meningitidis; D013045:Species Specificity; D014774:Virulence | Journal of medical microbiology | 1,984 | D000942:Antigens, Bacterial; D000939:Epitopes |
High total cholesterol levels in late life associated with a reduced risk of dementia. | OBJECTIVE
To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia.
METHODS
Neuropsychiatric, anthropometric, laboratory, and other assessments were conducted for 392 participants of a 1901 to 1902 birth cohort first examined at age 70. Follow-up examinati... | 10.1212/01.WNL.0000161870.78572.A5 | 15,911,792 | D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease; D001921:Brain; D002784:Cholesterol; D015331:Cohort Studies; D015897:Comorbidity; D015140:Dementia, Vascular; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia; D006949:Hyperlipidemias; D008137:Longitu... | Neurology | 2,005 | D014280:Triglycerides; D002784:Cholesterol |
Nurse scheduling in COVID-19-designated hospitals in China: A nationwide cross-sectional survey. | AIM
This study aimed to investigate scheduling in COVID-19-designated hospitals, including working hours, rest days, adverse nursing outcomes and their relationship.
BACKGROUND
Hospitals are at the forefront of COVID-19 prevention and control, and nurses are the main force on the frontline of the epidemic. Nursing sh... | 10.1111/jonm.13832 | 36,191,302 | D006801:Humans; D000086382:COVID-19; D003430:Cross-Sectional Studies; D010561:Personnel Staffing and Scheduling; D006761:Hospitals; D002681:China; D011795:Surveys and Questionnaires; D009741:Nursing Staff, Hospital | Journal of nursing management | 2,022 | |
Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury. | Oxidative stress is known to play a critical role in the pathogenesis of various disorders, especially in ischemia/reperfusion (I/R) injury. We identified an apoptosis-inducing humoral factor and named this novel post translationally modified secreted form of eukaryotic translation initiation factor 5A (eIF5A) "oxidati... | 10.1038/s41598-019-50073-8 | 31,534,168 | D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002545:Brain Ischemia; D015687:Cell Hypoxia; D020244:Infarction, Middle Cerebral Artery; D008297:Male; D009474:Neurons; D018384:Oxidative Stress; D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins; D051381:Rats; D011918:Rats, Inbr... | Scientific reports | 2,019 | D051017:Apoptosis Regulatory Proteins; D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins |
Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro. | Plasmodium vivax is the most widely distributed human malaria parasite. Despite its importance, both clinical research and basic research have been hampered by lack of a convenient in vitro culture system, in part due to the parasite's infection preference of reticulocytes rather than mature erythrocytes. The use of re... | 24,291,603 | D000818:Animals; D016645:Aotidae; D018929:Cell Culture Techniques; D002460:Cell Line; D015925:Cryopreservation; D004900:Erythroblasts; D006801:Humans; D016780:Malaria, Vivax; D051379:Mice; D010966:Plasmodium vivax; D012156:Reticulocytes | Parasitology international | 2,014 | ||
Associations between ADHD and eating disorders in relation to comorbid psychiatric disorders in a nationally representative sample. | The objective of this study was to examine whether previously observed associations of attention-deficit/hyperactivity disorder (ADHD) with eating disorders (EDs) are at least partially attributable to other underlying psychopathology. Data came from 4719 participants aged 18-44 years in the National Comorbidity Survey... | 10.1016/j.psychres.2017.11.026 | 29,172,099 | D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D001068:Feeding and Eating Disorders; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders; D011599:Psy... | Psychiatry research | 2,018 | |
[ "Weight phobia". A discussion of the problem of "atypical" and "not otherwise specified" eating and weight disorders]. | A number of authors have stated that the problem of classifying patients whose diagnosis does not meet all the criteria of anorexia and bulimia nervosa has not been satisfactorily solved. The question has been asked if it is justified to regard characteristics like "weight phobia" or body image disturbance as valid dia... | 10.1055/s-2000-13238 | 10,780,153 | D000855:Anorexia; D001828:Body Image; D001835:Body Weight; D002032:Bulimia; D001068:Feeding and Eating Disorders; D006801:Humans; D010556:Personality Tests; D011569:Psychiatric Status Rating Scales | Psychotherapie, Psychosomatik, medizinische Psychologie | 2,000 | |
DT-diaphorase activity and the cytotoxicity of quinones in C3H/10T1/2 mouse embryo cells. | A permanent mouse fibroblast cell line derived from C3H mouse embryos, C3H/10T1/2 C18, was used to study the cytotoxicity of some model quinones under conditions in which DT-diaphorase (EC 1.6.99.2) activity was induced or inhibited. Sudan III [1-[[4-(phenylazo)phenyl]azo]-2-naphthalenol] and 3-methylcholanthrene (MCA)... | 10.1016/0006-2952(88)90373-5 | 2,455,523 | D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D002083:Butylated Hydroxyanisole; D002470:Cell Survival; D002478:Cells, Cultured; D001728:Dicumarol; D004790:Enzyme Induction; D005347:Fibroblasts; D008748:Methylcholanthrene; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D0118... | Biochemical pharmacology | 1,988 | D011809:Quinones; D002083:Butylated Hydroxyanisole; D008748:Methylcholanthrene; D001728:Dicumarol; D001189:Aryl Hydrocarbon Hydroxylases; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases |
Do warming blankets increase bacterial counts in the operating field in a laminar-flow theatre? | Patient warming systems are used routinely to prevent hypothermia under anaesthesia. Airflow from warming blankets may potentially influence bacterial counts either by pumping 'dirty air' from floor level to the operating area or by blowing the patients' skin cells into the operating field from airflow under the blanke... | 10.1302/0301-620x.84b4.11974 | 12,043,764 | D001512:Bedding and Linens; D015169:Colony Count, Microbial; D004780:Environment, Controlled; D006358:Hot Temperature; D006801:Humans; D009873:Operating Rooms | The Journal of bone and joint surgery. British volume | 2,002 | |
Role of rapid virological response in prediction of sustained virological response to Peg-IFN plus ribavirin in HCV / HIV co-infected individuals. | The objective of the study was to evaluate the role of rapid virological response (RVR) in predicting sustained virological response (SVR) rates to hepatitis C virus (HCV) therapy. 65 HIV / HCV co-infected patients commenced HCV treatment per protocol. HIV / HCV patients with a mean CD4 count of 502 were treated for 24... | 10.1111/j.1365-2893.2008.00969.x | 18,221,297 | D000328:Adult; D000998:Antiviral Agents; D005260:Female; D005838:Genotype; D015658:HIV Infections; D016174:Hepacivirus; D006526:Hepatitis C; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008297:Male; D011092:Polyethylene Glycols; D012367:RNA, Viral; D011994:Recombinant Proteins; D012189:Retr... | Journal of viral hepatitis | 2,008 | D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin |
In vitro activity of levofloxacin and FK-037 against aerobic isolates from spontaneous bacterial peritonitis. | Spontaneous bacterial peritonitis is a potentially fatal complication of ascites, most often caused by the Enterobacteriaceae or streptococci. We have evaluated the in vitro activity of FK-037, a new cephalosporin, cefotaxime, cefpirome, ceftazidime, levofloxacin, and ofloxacin against a collection of 124 isolates from... | 10.1179/joc.1995.7.3.197 | 7,562,013 | D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001420:Bacteria, Aerobic; D015296:Ceftizoxime; D004755:Enterobacteriaceae; D006801:Humans; D007536:Isomerism; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin; D010538:Peritonitis; D013291:Streptococcus | Journal of chemotherapy (Florence, Italy) | 1,995 | D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; C079769:cefoselis; D064704:Levofloxacin; D015242:Ofloxacin; D015296:Ceftizoxime |
Percutaneous transplantation of human umbilical cord blood-derived multipotent stem cells in a canine model of spinal cord injury. | OBJECT
The authors describe a method for percutaneous transplantation of human umbilical cord blood (hUCB)-derived multipotent stem cells (MSCs) under fluoroscopic guidance. The investigators then tested whether percutaneous transplantation of hUCB-derived MSCs improved neurological functional recovery after acute spin... | 10.3171/2009.6.SPINE08710 | 19,951,029 | D000818:Animals; D002232:Carbocyanines; D003287:Contrast Media; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D004285:Dogs; D005456:Fluorescent Dyes; D005471:Fluoroscopy; D006801:Humans; D007124:Immunoenzyme Techniques; D039902:Multipotent Stem Cells; D011897:Random Allocation; D013119:S... | Journal of neurosurgery. Spine | 2,009 | C101089:CM-DiI; D002232:Carbocyanines; D003287:Contrast Media; D005456:Fluorescent Dyes |
Medical practice today. What members have to say research. | MGMA members employ creative ideas for weathering change in healthcare. | 20,669,743 | D001291:Attitude of Health Personnel; D057172:Economic Recession; D006123:Group Practice; D019538:Health Care Surveys; D006801:Humans; D014481:United States | MGMA connexion | 2,010 | ||
A label-free impedimetric DNA sensing chip integrated with AC electroosmotic stirring. | AC electroosmosis (ACEO) flow and label-free electrochemical impedance spectroscopy are employed to increase the hybridization rate and specifically detect target DNA (tDNA) concentrations. A low-ionic-strength solution, 6.1μS/cm 1mM Tris (pH 9.3), was used to produce ACEO and proved the feasibility of hybridization. A... | 23,357,000 | D015374:Biosensing Techniques; D004247:DNA; D058266:Dielectric Spectroscopy; D004867:Equipment Design; D019544:Equipment Failure Analysis; D044085:Microfluidics; D020411:Oligonucleotide Array Sequence Analysis; D013194:Staining and Labeling; D018511:Systems Integration | Biosensors & bioelectronics | 2,013 | D004247:DNA | |
Scatter analysis of discrete-sized chromatin fragments favours a cylindrical organization. | Fragments of chromatin containing 23 +/- 2.5 nucleosomes have been fractionated after light nuclease treatment of chicken erythrocyte nuclei. Low-angle scattering measures the total z-average radius of gyration of the already well-defined particles and the shape of scatter curves can be compared with three-dimensional ... | 10.1111/j.1432-1033.1985.tb09098.x | 4,029,135 | D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D002843:Chromatin; D004912:Erythrocytes; D008433:Mathematics; D009502:Neutrons; D009707:Nucleosomes; D010316:Particle Size; D010446:Peptide Fragments; D011487:Protein Conformation; D012542:Scattering, Radiation; D014965:X-Rays | European journal of biochemistry | 1,985 | D002843:Chromatin; D009707:Nucleosomes; D010446:Peptide Fragments |
Subclinical, hemodynamic, and echocardiographic abnormalities of high pulse pressure in hypertensive and non-hypertensive adults. | BACKGROUND
High pulse pressure (PP) is associated with cardiovascular events, but subclinical abnormalities in cardiac structure and function in relation to high pulse pressure are not well described.
METHODS AND RESULTS
2225 hypertensive and 1380 non-hypertensive participants with adequate echocardiographic left ven... | 23,173,105 | American journal of cardiovascular disease | 2,012 | |||
Impact of an online, individualised, patient reported outcome measures based patient decision aid on patient expectations, decisional regret, satisfaction, and health-related quality-of-life for patients considering total knee arthroplasty: Results from a randomised controlled trial. | RATIONALE
Total knee arthroplasty is a common surgical procedure but not appropriate for all patients with knee osteoarthritis. Patient decision aids (PtDAs) can promote shared decision making and enhance understanding and expectations of procedures among patients, resulting in better discussions between patients and h... | 10.1111/jep.13804 | 36,575,631 | D006801:Humans; D017060:Patient Satisfaction; D019645:Arthroplasty, Replacement, Knee; D011446:Prospective Studies; D009042:Motivation; D011788:Quality of Life; D020370:Osteoarthritis, Knee; D010549:Personal Satisfaction; D003661:Decision Support Techniques; D000071066:Patient Reported Outcome Measures | Journal of evaluation in clinical practice | 2,023 | |
Sex determination and disorders of sex development according to the revised nomenclature and classification in 46,XX individuals. | There have been considerable advances concerning understanding of the early and later stages of ovarian development; a number of genes have been implicated and their mutations have been associated with developmental abnormalities. The most important genes controlling the initial phase of gonadal development, identical ... | 10.14310/horm.2002.1272 | 20,688,619 | D041321:Chromosomes, Human, X; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005835:Genitalia; D005838:Genotype; D023961:Gonadal Dysgenesis, 46,XX; D006801:Humans; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D012732:Sex Determination Analysis; D019849:Sex Determination Processes; D046468... | Hormones (Athens, Greece) | 2,010 | |
Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies. | Mitochondria act as key organelles in cellular bioenergetics and biosynthetic processes producing signals that regulate different molecular networks for proliferation and cell death. This ability is also preserved in pathologic contexts such as tumorigenesis, during which bioenergetic changes and metabolic reprogrammin... | 10.1111/febs.16218 | 34,606,156 | D006801:Humans; D042967:Electron Transport Complex I; D009369:Neoplasms; D008928:Mitochondria; D004734:Energy Metabolism; D063646:Carcinogenesis; D059016:Tumor Microenvironment | The FEBS journal | 2,022 | D042967:Electron Transport Complex I |
Testis sparing surgery in the treatment of bilateral testicular germ cell tumors and solitary testicle tumors: A single institution experience. | BACKGROUND AND OBJECTIVE
To assess the oncologic and functional outcomes of testicular sparing surgery (TSS) based on a single institution experience.
METHODS
Forty-one patients with bilateral and 3 patients with solitary testicle tumors were referred to our institution. The inclusion criteria for TSS were normal ser... | 10.1002/jso.23777 | 25,195,665 | D000293:Adolescent; D000328:Adult; D053713:Azoospermia; D059247:Fertility Preservation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal; D009919:Orchiectomy; D059351:Organ Sparing Treatments; D013076:Sperm Count... | Journal of surgical oncology | 2,015 | D013739:Testosterone |
Transcutaneous Electrical Acupoint Stimulation in Early Life Changes Synaptic Plasticity and Improves Symptoms in a Valproic Acid-Induced Rat Model of Autism. | Autism spectrum disorder (ASD) is a developmental disorder characterized by social behavior deficit in childhood without satisfactory medical intervention. Transcutaneous electrical acupoint stimulation (TEAS) is a noninvasive technique derived from acupuncture and has been shown to have similar therapeutic effects in ... | 10.1155/2020/8832694 | 33,456,456 | D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000367:Age Factors; D000818:Animals; D001321:Autistic Disorder; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling; D008297:Male; D009473:Neuronal Plasticity; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid; D014828:Vocal... | Neural plasticity | 2,020 | D014635:Valproic Acid |
Polyethylene-starch extrudates as erodible carriers for bioactive materials: I. Erodibility and in vitro dye release studies. | The objective of the present investigation is to develop and evaluate polyethylene-starch based carriers for sustaining the release of bioactive materials. Polyethylene-starch carriers were prepared by incorporating various amounts of corn starch 0, 40, 80, and 100% in polyethylene beads with and without dye. Acid oran... | 10.1177/088532829400800306 | 8,176,638 | D004396:Coloring Agents; D004337:Drug Carriers; D008855:Microscopy, Electron, Scanning; D011095:Polyethylenes; D013213:Starch | Journal of biomaterials applications | 1,994 | D004396:Coloring Agents; D004337:Drug Carriers; D011095:Polyethylenes; D013213:Starch |
Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison. | OBJECTIVE
To assess the safety and efficacy of early amino acid (AA) administration in preterm neonates <28 weeks gestational age.
STUDY DESIGN
Prospective data collection for 1 year for the late AA group (AA started at 12-30 h) and for another year with practice change to early AA administration (immediately after s... | 10.1038/sj.jp.7211611 | 17,024,139 | D000596:Amino Acids; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D019370:Observation; D010288:Parenteral Nutrition; D011446:Prospective Studies; D018805:Sepsis; D014508:Urea; D015430:Weight Gain | Journal of perinatology : official journal of the California Perinatal Association | 2,006 | D000596:Amino Acids; D014508:Urea |
Tuberculous infection in a vascular prosthesis: a case of aortic graft infection resulting from disseminated tuberculosis. | Insertion of an aortic prosthetic bypass graft in a patient with untreated disseminated tuberculosis resulted in graft infection with formation of a pseudoaneurysm. Microbiologic cultures implicated Mycobacterium tuberculosis as the causative agent, and a subsequent review of the literature indicated this report to be ... | 10.1001/archsurg.1977.01370010081016 | 401,636 | D001011:Aorta; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D014398:Tuberculosis, Renal | Archives of surgery (Chicago, Ill. : 1960) | 1,977 | |
Risk and direct protective factors for youth violence: results from the National Longitudinal Study of Adolescent Health. | BACKGROUND
The majority of studies on youth violence have focused on factors that increase the risk for youth violence.
PURPOSE
To assess whether determinants of violence operate as risk factors, direct protective factors, or both during adolescence and young adulthood.
METHODS
Data from participants in the Nationa... | 10.1016/j.amepre.2012.04.023 | 22,789,958 | D000293:Adolescent; D000294:Adolescent Behavior; D000367:Age Factors; D005195:Family Relations; D005260:Female; D006801:Humans; D007604:Juvenile Delinquency; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D010379:Peer Group; D012307:Risk Factors; D014481:United States; D014754:Violence; D055815:Yo... | American journal of preventive medicine | 2,012 | |
The Impact of Expasyl® Gingival Retraction Paste on the Bond Strength of Self-etch and Total-etch Systems. | OBJECTIVE
To evaluate the influence of Expasyl® gingival retraction paste on the shear bond strength of self-etch and total-etch adhesive systems.
MATERIALS AND METHODS
Twenty-four specimens of extracted, caries-free, sound human molars were used in this study. The molars were then cut vertically into halves through ... | 10.5005/jp-journals-10024-1686 | 26,162,250 | D000134:Acid Etching, Dental; D001252:Astringents; D003188:Composite Resins; D001840:Dental Bonding; D003764:Dental Materials; D003804:Dentin; D060745:Gingival Retraction Techniques; D006801:Humans; D008422:Materials Testing; D010756:Phosphoric Acids; D011109:Polymethacrylic Acids; D019279:Resin Cements; D033081:Shear ... | The journal of contemporary dental practice | 2,015 | D001252:Astringents; D003188:Composite Resins; D003764:Dental Materials; D010756:Phosphoric Acids; D011109:Polymethacrylic Acids; C425843:Prime and Bond NT; D019279:Resin Cements; C121818:Tetric ceram; C030242:phosphoric acid |
Sedentary Behavior Is an Independent Predictor of Mortality in Subjects With COPD. | BACKGROUND
The terms sedentary behavior and physical inactivity have been confusingly mixed. Although the association between physical inactivity and mortality has been shown previously in subjects with COPD, this association had not yet been investigated with regard to sedentarism. The aim of this work was to investig... | 10.4187/respcare.05306 | 28,270,544 | D000368:Aged; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D029424:Pulmonary Disease, Chronic Obstructive; D012189:Retrospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:T... | Respiratory care | 2,017 | |
Extracting knowledge from a large primary health care database using a knowledge-based statistical approach. | Clinical databases from automated medical records represent a growing resource for deriving new medical knowledge. In this study a large primary health care database was explored with respect to the association between hypertension and diabetes. Data collection was made with a query language, and data analysis performe... | 10.1007/BF00999270 | 2,093,741 | D000368:Aged; D000369:Aged, 80 and over; D001185:Artificial Intelligence; D003628:Database Management Systems; D016208:Databases, Factual; D003661:Decision Support Techniques; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D008432:Mathematical Computing; D008875:Midd... | Journal of medical systems | 1,990 | |
[Treatment of inguinal hernia: a prospective study comparing Bassini's procedure, the inguinal pre-peritoneal prosthesis and the Lichtenstein technique]. | Inguinal hernia surgery has aroused considerable interest in recent years, with numerous advances being proposed to treat these disorders. Bassini's procedure, based on the importance of the transversalis fascia as a fundamental containment mechanism, was for many years the treatment of choice for inguinal hernia. In o... | 12,192,926 | D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006552:Hernia, Inguinal; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D012008:Recurrence; D013526:Surgical Mesh; D013997:Time Factors | Chirurgia italiana | 2,002 | ||
Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery. | The synthetic peptide bearing Arg-Gly-Asp (RGD) sequence is considered to specifically bind to alpha(v)beta(3) integrin expressed on endothelial cells in the angiogenic blood vessels, which provides a potential to inhibit the tumor growth. As a carrier for the RGD peptide, hydrophobically modified glycol chitosan (HGC)... | 10.1016/j.jconrel.2003.12.020 | 15,023,468 | D000595:Amino Acid Sequence; D020533:Angiogenesis Inhibitors; D048271:Chitosan; D002757:Cholanes; D002793:Cholic Acids; D004337:Drug Carriers; D042783:Endothelial Cells; D016650:Fluorescein-5-isothiocyanate; D006801:Humans; D039302:Integrin alphaVbeta3; D008722:Methods; D009842:Oligopeptides; D010316:Particle Size; D01... | Journal of controlled release : official journal of the Controlled Release Society | 2,004 | D020533:Angiogenesis Inhibitors; D002757:Cholanes; D002793:Cholic Acids; D004337:Drug Carriers; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C118638:glycol-chitosan; C047981:arginyl-glycyl-aspartic acid; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate; C007036:cholanic acid |
Athletic footwear, leg stiffness, and running kinematics. | CONTEXT
The leg acts as a linear spring during running and hopping and adapts to the stiffness of the surface, maintaining constant total stiffness of the leg-surface system. Introducing a substance (eg, footwear) may affect the stiffness of the leg in response to changes in surface stiffness.
OBJECTIVE
To determine ... | 17,273,463 | Journal of athletic training | 2,006 | |||
Respiratory muscle force and ventilatory function in adolescents. | In 94 girls and 90 boys, aged 12.5-20.3 yr, the relationship of respiratory pressures or forces with lung volumes and ventilatory flows was studied. There was great variability in respiratory muscle performance, which helps to explain differences in lung volumes between individuals. Respiratory muscle force increases a... | 3,396,676 | D000293:Adolescent; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D009119:Muscle Contraction; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012132:Respiratory Muscles; D012727:Sex Characteristics | The European respiratory journal | 1,988 | ||
Effect of quinacrine treatment on the activity of acid hydrolases (phosphatase, N-acetyl-beta-glucosaminidase, glucosidase, galactosidase and esterase) in Tetrahymena. | The effect of phospholipase A2 (PLA2) inhibitor, quinacrine, on the activity of hydrolytic enzymes in Tetrahymena pyriformis homogenate, was investigated. The activity of all of the enzymes studied (acid phosphatase, N-acetyl-beta-glusosaminidase, glucosidase, galactosidase and esterase) was significantly reduced in th... | 10.1002/cbf.928 | 11,746,211 | D000098:Acetophenones; D000118:Acetylglucosaminidase; D000135:Acid Phosphatase; D000818:Animals; D000962:Antimalarials; D002458:Cell Fractionation; D004791:Enzyme Inhibitors; D004950:Esterases; D005696:Galactosidases; D005959:Glucosidases; D006867:Hydrolases; D011796:Quinacrine; D013769:Tetrahymena pyriformis | Cell biochemistry and function | 2,001 | D000098:Acetophenones; D000962:Antimalarials; D004791:Enzyme Inhibitors; D006867:Hydrolases; D004950:Esterases; D000135:Acid Phosphatase; D005696:Galactosidases; D005959:Glucosidases; D000118:Acetylglucosaminidase; D011796:Quinacrine; C006821:4-bromophenacyl bromide |
[Evaluation of potential damage to the regenerate during callus molding after mandibular distraction osteogenesis. Experimental study using an animal model]. | BACKGROUND
Molding the regenerate created by distraction osteogenesis has clinically been shown to be an efficient lifeboat, good enough that for complex three-dimensional deformities final adjustments by molding the regenerate may be part of the treatment plan. The study assessed the limits of molding a regenerate, ta... | 10.1007/s10006-005-0611-y | 15,856,346 | D000818:Animals; D015519:Bone Density; D001861:Bone Regeneration; D016723:Bone Remodeling; D002146:Bony Callus; D004285:Dogs; D005260:Female; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008334:Mandible; D019857:Osteogenesis, Distraction | Mund-, Kiefer- und Gesichtschirurgie : MKG | 2,005 | |
Relationship between asthma control status, the Asthma Control Test™ and urgent health-care utilization in Asia. | BACKGROUND AND OBJECTIVE
Accurate assessment of control is an integral part of asthma management. We investigated the relationship between control status derived from the Global Initiative for Asthma (GINA), the Asthma Control Test (ACT) and urgent health-care utilization.
METHODS
Asthma Insights and Reality in Asia-... | 10.1111/j.1440-1843.2011.01954.x | 21,362,102 | D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D001208:Asia; D001249:Asthma; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003695:Delivery of Health Care; D005260:Female; D019538:Health Care Surveys; D006760:Hospitalization; D006801:Humans; D008297:Male; D008991:Monitoring, Phy... | Respirology (Carlton, Vic.) | 2,011 | |
Ultrasound-Guided Ganglionectomy of a Flexor Hallucis Longus Ganglion Cyst Using Coablation Technology: A Case Report. | A 44-year-old woman with a history of an open ganglionectomy 2 years prior presented with a recurrent ganglion cyst. The ganglion cyst, extending from the flexor hallucis longus tendon sheath, was confirmed with magnetic resonance imaging. The patient declined another surgical incision. An experimental procedure was pe... | 10.1002/pmrj.12084 | 30,688,038 | D000328:Adult; D017115:Catheter Ablation; D005260:Female; D045888:Ganglion Cysts; D015171:Ganglionectomy; D006801:Humans; D025321:Surgery, Computer-Assisted; D013710:Tendons; D014463:Ultrasonography | PM & R : the journal of injury, function, and rehabilitation | 2,019 | |
The Use of Multiparametric Magnetic Resonance Imaging for Follow-up of Patients Included in Active Surveillance Protocol. Can PSA Density Discriminate Patients at Different Risk of Reclassification? | INTRODUCTION
The objective of this study was to test Prostate Imaging Reporting and Data System (PI-RADS) classification on multiparametric magnetic resonance imaging (mpMRI) and MRI-derived prostate-specific antigen density (PSAD) in predicting the risk of reclassification in men in active surveillance (AS), who under... | 10.1016/j.clgc.2020.04.006 | 32,493,676 | D005500:Follow-Up Studies; D006801:Humans; D061705:Image-Guided Biopsy; D008279:Magnetic Resonance Imaging; D008297:Male; D000081364:Multiparametric Magnetic Resonance Imaging; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D057832:Watchful Waiting | Clinical genitourinary cancer | 2,020 | D017430:Prostate-Specific Antigen |
MOF-Derived Bimetallic Pd-Co Alkaline ORR Electrocatalysts. | The development of highly active, durable, and low-cost electrocatalysts for the oxygen reduction reaction (ORR) has been of paramount importance for advancing and commercializing fuel cell technologies. Here, we report on a novel family of Pd-Co binary alloys (PdCo, x = 1-6) embedded in bimetallic organic framework (B... | 10.1021/acsami.2c10074 | 36,153,946 | ACS applied materials & interfaces | 2,022 | ||
Stromal Clues in Endometrial Carcinoma: Loss of Expression of β-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor. | Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epit... | 10.1097/PGP.0000000000000233 | 26,367,784 | D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015820:Cadherins; D018269:Carcinoma, Endometrioid; D016889:Endometrial Neoplasms; D004717:Endometrium; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; ... | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists | 2,016 | D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D051176:beta Catenin |
Potentiating effects of leukotriene B4 and prostaglandin E2 on urinary sodium excretion by the dog kidney. | A synergistic vasodilatation was recently demonstrated with leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in the cutaneous microcirculation. The present study addresses this question to the renal microcirculation, with respect to its eventual influence on the net transport of sodium, infusing small doses of LTB4 (1... | 10.1016/0262-1746(85)90052-6 | 2,987,978 | D000818:Animals; D015232:Dinoprostone; D004231:Diuresis; D004285:Dogs; D004357:Drug Synergism; D005260:Female; D007668:Kidney; D007975:Leukotriene B4; D009318:Natriuresis; D011458:Prostaglandins E | Prostaglandins, leukotrienes, and medicine | 1,985 | D011458:Prostaglandins E; D007975:Leukotriene B4; D015232:Dinoprostone |
Determination of stromal signatures in breast carcinoma. | Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumor... | 10.1371/journal.pbio.0030187 | 15,869,330 | D001943:Breast Neoplasms; D018076:DNA, Complementary; D004273:DNA, Neoplasm; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma; D006801:Humans; D015999:Multivariate Analysis; D020411:Oligonucleotide Array Sequence Analysis; D012983:Soft Tissue Neoplasms; D017154:Stromal Cells | PLoS biology | 2,005 | D018076:DNA, Complementary; D004273:DNA, Neoplasm |
Programmable Versus Differential Pressure Ventriculoperitoneal Shunts for Pediatric Hydrocephalus: A 20-Year Single-Center Experience From Saudi Arabia. | Background Shunt malfunction is the most common complication after ventriculoperitoneal shunt (VPS) insertion for pediatric hydrocephalus. The incidence of shunt malfunction and the need for VPS revision may be related to the type of valve used in the shunt. Therefore, we aimed to compare the outcome of VPS in the pedi... | 10.7759/cureus.43369 | 37,700,950 | Cureus | 2,023 | ||
Induction of parturition in a commercial dairy herd: clinical management and treatment. | Twenty-six dairy cattle were treated with dexamethasone during medium to late pregnancy to induce premature calving. Thirteen produced calves within an average of 5-6 days of treatment. The remainder were given a subsequent injection of cloprostenol 10 days after the steroid treatment and, with one exception, all calve... | 10.1136/vr.111.16.363 | 7,147,658 | D000818:Animals; D002417:Cattle; D003008:Cloprostenol; D003907:Dexamethasone; D005260:Female; D007273:Injections, Intramuscular; D007751:Labor, Induced; D007752:Obstetric Labor, Premature; D011247:Pregnancy | The Veterinary record | 1,982 | C035966:dexamethasone 21-phenylpropionate; D003008:Cloprostenol; D003907:Dexamethasone |
[Laser therapy of elderly patients with pneumonia]. | The aim of the study was to evaluate the efficiency of laser therapy included into the treatment of pneumonia in the elderly. A follow-up included the analysis of their clinical status and external respiratory function, pulmonary blood flow, and immunological parameters in 2 matched groups of pneumonia patients aged 60... | 11,550,371 | D000368:Aged; D006801:Humans; D028022:Low-Level Light Therapy; D008875:Middle Aged; D011014:Pneumonia | Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury | 2,001 | ||
Psychologic and psychosocial aspects of renal transplantation. | This article focuses on some of the more common psychologic and psychosocial issues which confront renal transplant patients and their families. Even though renal graft failure is not life threatening as it is in heart and liver graft failure, the renal transplant patient nonetheless undergoes psychologic turmoil and s... | 10.1097/00002727-199502000-00010 | 7,866,893 | D000223:Adaptation, Psychological; D005190:Family; D006801:Humans; D016030:Kidney Transplantation | Critical care nursing quarterly | 1,995 | |
Characterisation of local Ghanaian chickens: growth performance evaluation based on Richards growth model and genetic size scaling. | The Richards growth model was fitted to body weight-age data of local and SASSO T44 chickens to describe their growth performance. Males had higher (P < 0.05) asymptotic mature weights than females. Within the local chicken population, birds from the savannah zone had higher (P < 0.05) asymptotic mature weights compare... | 10.1007/s11250-011-9825-1 | 21,455,693 | D000818:Animals; D001835:Body Weight; D002645:Chickens; D004777:Environment; D005260:Female; D005838:Genotype; D005869:Ghana; D016014:Linear Models; D008297:Male; D008954:Models, Biological; D017678:Sex Distribution; D012741:Sexual Maturation | Tropical animal health and production | 2,011 | |
Effect of hexavalent chromium on proliferation and differentiation to adipocytes of 3T3-L1 fibroblasts. | Heavy metals contamination has become an important risk factor for public health and the environment. Chromium is a frequent industrial contaminant and is also used in orthopaedic joint replacements made from cobalt-chromium-alloy. Since hexavalent chromium (Cr(VI)) was reported as genotoxic and carcinogenic in differe... | 24,576,443 | D041721:3T3-L1 Cells; D017667:Adipocytes; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002857:Chromium; D004785:Environmental Pollutants; D005347:Fibroblasts; D051379:Mice | Toxicology in vitro : an international journal published in association with BIBRA | 2,014 | D004785:Environmental Pollutants; D002857:Chromium; C074702:chromium hexavalent ion | |
The first case of micropapillary adenocarcinoma associated with cystic airspace in a non-smoking man. | Lung cancers associated with cystic airspaces are attracting increasing attention because of delayed diagnosis. The cancers that usually occur in smokers comprise lepidic, papillary, and/or acinar adenocarcinoma, but a micropapillary type has not been described to date. Pulmonary micropapillary adenocarcinoma was added... | 10.1002/rcr2.513 | 31,867,109 | Respirology case reports | 2,020 | ||
Arterial elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy. | Systolic and pulse blood pressures are stronger predictors of stroke, coronary heart disease, myocardial infarction, heart failure, end-stage renal disease, and cardiovascular mortality than diastolic pressure. Furthermore, diastolic pressure is inversely related to coronary heart disease and cardiovascular mortality. ... | 10.1177/107424840100600102 | 11,452,332 | D000328:Adult; D000368:Aged; D000375:Aging; D000959:Antihypertensive Agents; D001011:Aorta; D001158:Arteries; D001794:Blood Pressure; D002318:Cardiovascular Diseases; D004548:Elasticity; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension; D008875:Middle Aged; D020521:Stroke; D013599:Systole; D014655:Vascular Re... | Journal of cardiovascular pharmacology and therapeutics | 2,001 | D000959:Antihypertensive Agents |
Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. | Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence in... | 10.1002/ijc.25504 | 20,533,550 | D015331:Cohort Studies; D015179:Colorectal Neoplasms; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D052756:Nutritional Sciences; D017698:Postmenopause; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys ... | International journal of cancer | 2,011 | |
Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022. | BACKGROUND
Enhanced Recovery After Surgery (ERAS) has been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016. The aim of the present article was to update the ERAS guidelines in liver surgery using a modified Delphi method based on a systematic review of the literature.
METHOD... | 10.1007/s00268-022-06732-5 | 36,310,325 | D006801:Humans; D000080482:Enhanced Recovery After Surgery; D000082622:Preoperative Exercise; D056164:Teaching Rounds; D008099:Liver | World journal of surgery | 2,023 | |
Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli. | We present evidence that human immunodeficiency virus (HIV) reverse transcriptase (RT) can substitute for DNA polymerase I in bacteria. Expression of HIV RT enables an Escherichia coli mutant, polA12 recA718, containing a temperature-sensitive mutation in DNA polymerase I, to grow at a nonpermissive temperature. The pl... | 10.1073/pnas.92.3.684 | 7,531,338 | D004256:DNA Polymerase I; D004261:DNA Replication; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli; D005816:Genetic Complementation Test; D006678:HIV; D006801:Humans; D009154:Mutation; D010957:Plasmids; D012194:RNA-Directed DNA Polymerase; D013696:Temperature; D015215:Zidovudine | Proceedings of the National Academy of Sciences of the United States of America | 1,995 | D015215:Zidovudine; D012194:RNA-Directed DNA Polymerase; D004256:DNA Polymerase I |
A metastatic glomus jugulare tumor. A temporal bone report. | The clinicopathologic findings in the temporal bone of a patient with a highly malignant metastasizing glomus jugulare tumor are reported. The patient exhibited all the symptoms of primary malignant tumors of the ear, including facial paralysis, otorrhea, pain, hearing loss, tinnitus, dizziness, and vertigo. He was tre... | 6,326,582 | D000328:Adult; D001918:Brachytherapy; D003037:Cobalt Radioisotopes; D003131:Combined Modality Therapy; D005925:Glomus Jugulare Tumor; D006470:Hemorrhage; D006801:Humans; D007759:Labyrinth Diseases; D008297:Male; D008416:Mastoid; D010236:Paraganglioma, Extra-Adrenal; D011883:Radium; D012888:Skull Neoplasms; D013701:Temp... | The American journal of otology | 1,984 | D003037:Cobalt Radioisotopes; D011883:Radium | |
To grab the stroma by the horns: from biology to cancer therapy with mesenchymal stem cells. | Mesenchymal stem or stromal cells (MSCs) are precursor cells that play important roles in tumorigenesis. MSCs are recruited to tumors from local and distant sources to form part of the tumor microenvironment. MSCs influence tumor progression by interacting with cancer cells, endothelial cells, immune cells, and cancer ... | 10.18632/oncotarget.1040 | 23,744,479 | D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D009362:Neoplasm Metastasis; D009369:Neoplasms; D059016:Tumor Microenvironment | Oncotarget | 2,013 | |
Factors influencing colonisation with gentamicin resistant gram negative organisms in the neonatal unit. | The proportion of babies colonised with gentamicin resistant Gram negative organisms in a nursery over a 30 month period did not correlate with the quantity or duration of aminoglycosides used, but it did correlate with two indicators of workload: the number of baby days and a score based on the level of nursing care r... | 10.1136/adc.63.5.533 | 3,389,870 | D001424:Bacterial Infections; D003422:Critical Care; D004352:Drug Resistance, Microbial; D005839:Gentamicins; D006090:Gram-Negative Bacteria; D006801:Humans; D007224:Infant Care; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D013997:Time Factors | Archives of disease in childhood | 1,988 | D005839:Gentamicins |
[Tuberculosis miliar in a patient treated with intravesical instillations of bacillus Calmette-Guérin]. | Tuberculosis miliar is a very rare complication of bacillus Calmette-Guérin (BCG) immunotherapy that is associated to high mortality. Thus, early diagnosis and treatment is essential. At present, there is a polymerase chain reaction technique (PCR) which is a rapid diagnostic method with elevated sensitivity. Treatment... | 10.1016/s0210-5691(06)74485-0 | 16,729,480 | D000276:Adjuvants, Immunologic; D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine; D004269:DNA, Bacterial; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure; D009163:Mycobacterium bovis; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic; D014391:Tub... | Medicina intensiva | 2,006 | D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D004269:DNA, Bacterial |
Long-wavelength photosensitivity in coral planula larvae. | Light influences the swimming behavior and settlement of the planktonic planula larvae of coral, but little is known regarding the photosensory biology of coral at this or any life-history stage. Here we used changes in the electrical activity of coral planula tissue upon light flashes to investigate the photosensitivi... | 10.1086/BBLv222n2p88 | 22,589,399 | D000818:Animals; D037421:Anthozoa; D003116:Color; D055724:Electrophysiological Phenomena; D056890:Eukaryota; D007814:Larva; D008027:Light; D010775:Photic Stimulation; D013559:Symbiosis | The Biological bulletin | 2,012 | |
Clinical, Biochemical, Radiological, Genetic and Therapeutic Analysis of Patients with COMP Gene Variants. | Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia type 1 (MED1) are two rare skeletal disorders caused by cartilage oligomeric matrix protein (COMP) variants. This study aims to analyze the genotype and phenotype of patients with COMP variants. Clinical information for 14 probands was collected; DNA was ex... | 10.1007/s00223-021-00920-6 | 34,709,441 | D000130:Achondroplasia; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D006801:Humans; D064235:Matrilin Proteins; D009154:Mutation | Calcified tissue international | 2,022 | C577544:COMP protein, human; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins |
Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment. | The mouse bone marrow micronucleus (MN) assay holds a key position in all schemes for detecting potential human carcinogens and mutagens. It was therefore of concern when Shelby et al. reported that only 5 of 25 rodent carcinogens defined by the U.S. NTP were positive in the assay. Further, each of these positive respo... | 10.1289/ehp.94102758 | 9,657,707 | D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D006801:Humans; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens | Environmental health perspectives | 1,994 | D002273:Carcinogens; D009153:Mutagens |
[Clinical study of Philadelphia chromosome-positive adult acute lymphoblastic leukemia]. | OBJECTIVE
To study the clinical characteristics, risk factors and therapeutic outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia (Ph(+)aALL).
METHODS
The clinical data of 117 newly diagnosed adults with Ph(+)ALL in our hospital between January 1995 and December 2009 were retrospectively an... | 22,339,953 | D000328:Adult; D001549:Benzamides; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010677:Philadelphia Chromosome; D010879:Piperazines; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D011379:Prognosis; D011743:Pyrimidines; D012189:Retrospective Studies | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | 2,011 | D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate | |
Integration of single-molecule detection with endonuclease IV-assisted signal amplification for sensitive DNA methylation assay. | We demonstrate the development of a new fluorescent biosensor for sensitive DNA methylation assay by integrating single-molecule detection with endo IV-assisted signal amplification. This biosensor possesses the characteristics of good selectivity and high sensitivity with a detection limit of 7.3 × 10-17 M. It can dis... | 10.1039/d0cc08306b | 33,507,186 | D015374:Biosensing Techniques; D004247:DNA; D019175:DNA Methylation; D043223:Deoxyribonuclease IV (Phage T4-Induced); D056945:Hep G2 Cells; D006801:Humans; D000072760:Single Molecule Imaging | Chemical communications (Cambridge, England) | 2,021 | D004247:DNA; D043223:Deoxyribonuclease IV (Phage T4-Induced) |
Direct administration of testosterone increases rat tibial epiphyseal growth plate width. | Local injection of hormones into the tibial epiphyseal growth plate offers a possible model to answer whether sex steroids can affect bone growth directly. To answer this question, we injected different doses of testosterone enanthate (4, 40, 120 and 400 micrograms/100 g of rat weight) once into the tibial epiphyseal g... | 10.1530/acta.0.1210401 | 2,800,918 | D000818:Animals; D006132:Growth Plate; D007334:Insulin-Like Growth Factor I; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone; D013977:Tibia | Acta endocrinologica | 1,989 | D013739:Testosterone; D007334:Insulin-Like Growth Factor I; C004648:testosterone enanthate |
Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. | CONTEXT
There is a paucity of effective, well-tolerated drugs available for migraine prophylaxis.
OBJECTIVE
To determine whether treatment with the angiotensin II receptor blocker candesartan is effective as a migraine-prophylactic drug.
DESIGN AND SETTING
Randomized, double-blind, placebo-controlled crossover stud... | 10.1001/jama.289.1.65 | 12,503,978 | D000328:Adult; D000804:Angiotensin II; D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders; D012720:Severity of Illness Index; D013777:Tetrazoles; D016896:Tr... | JAMA | 2,003 | D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013777:Tetrazoles; D000804:Angiotensin II; C081643:candesartan |
Endoscopic definition of esophagogastric junction for diagnosis of Barrett's esophagus: importance of systematic education and training. | The diagnosis of Barrett's esophagus (BE) requires an accurate recognition of the columnar-lined esophagus at endoscopy. However, a universally accepted standardized endoscopic grading system of BE was lacking prior to the development of the Prague 'circumferential and maximal' criteria. In this system, the landmark fo... | 10.1111/j.1443-1661.2009.00895.x | 19,961,518 | D001471:Barrett Esophagus; D004724:Endoscopy; D004943:Esophagogastric Junction; D006801:Humans; D007564:Japan; D011237:Predictive Value of Tests; D015203:Reproducibility of Results | Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society | 2,009 | |
Prediction of aortic valvular area and gradient by noninvasive techniques. | Sixty-two patients with isolated aortic valvular stenosis were analyzed by a series of common noninvasive procedures and by cardiac catheterization. The data from 50 of these were evaluated in a retrospective fashion by multiple regression methods to determine significant objectively obtained predictors of aortic-left ... | 10.1016/0002-8703(78)90361-7 | 146,423 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis; D002118:Calcium; D006328:Cardiac Catheterization; D006332:Cardiomegaly; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011312:Pressure; D013997:Time Factors | American heart journal | 1,978 | D002118:Calcium |
Who Is Your Doctor? Analysis of Patient-Reported and EHR-Imputed Primary Care Physician. | Significant efforts have been made to improve physician-to-physician communication and care coordination during transition of care in order to reduce adverse events and readmissions. As electronic health records (EHRs) become widely available, many hospitals have implemented physician collaboration and hand-off tools t... | 29,295,061 | D003142:Communication; D057286:Electronic Health Records; D006760:Hospitalization; D006801:Humans; D018802:Patient-Centered Care; D058007:Physicians, Primary Care; D011320:Primary Health Care | Studies in health technology and informatics | 2,017 | ||
Morphogenesis and pathogenesis of chronic lung diseases. vii. Kinetics of alkaline phosphatase active cells during the development of experimental lung granulomas. | The circulating cells arriving at the formation site of the experimentally induced lung granuloma were quantitatively and qualitatively determined during their development by estimation of alkaline phosphatase active free cells. These represent 32 per cent the 2nd day and 27 per cent the 4th, of all the lung granuloma ... | 127,940 | D000469:Alkaline Phosphatase; D000818:Animals; D002908:Chronic Disease; D006099:Granuloma; D008171:Lung Diseases; D008297:Male; D009000:Monocytes; D011817:Rabbits | Morphologie et embryologie | 1,975 | D000469:Alkaline Phosphatase | |
Observations about family interaction and the effect of therapy: interviews with families eight years after the onset of schizophrenia. | This study focused on the development of and changes in the interaction within a family after the onset of schizophrenia in a family member. Special attention is given to the possible effects of various treatments on the interaction. Our method was a circular interview of all family members in a joint session 8 years a... | 10.1111/j.1545-5300.1989.00373.x | 2,599,064 | D005190:Family; D005196:Family Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012559:Schizophrenia; D013997:Time Factors | Family process | 1,989 | |
Diffusion regulated growth characteristics of a spherical prevascular carcinoma. | Recently a mathematical model of the prevascular phases of tumor growth by diffusion has been investigated (S.A. Maggelakis and J.A. Adam, Math. Comput. Modeling, in press). In this paper we examine in detail the results and implications of that mathematical model, particularly in the light of recent experimental work ... | 10.1007/BF02462267 | 2,397,329 | D000818:Animals; D002455:Cell Division; D004058:Diffusion; D006131:Growth Inhibitors; D008433:Mathematics; D008954:Models, Biological; D009336:Necrosis; D009374:Neoplasms, Experimental; D010101:Oxygen Consumption | Bulletin of mathematical biology | 1,990 | D006131:Growth Inhibitors |
[Hepatitis A outbreak in Transdanubia (Hungary): molecular connections and epidemiological conclusions - 2006]. | INTRODUCTION
Hepatitis A virus (HAV) is one of the most important cause of fecally transmitted acute infectious hepatitis worldwide. In Hungary, beside the sporadic HAV infections, outbreaks also occur, particularly in Northeast part of the country where the subgenotype IA is endemic. The reported number of HAV cases w... | 10.1556/OH.2007.28096 | 17,526,446 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006506:Hepatitis A; D030041:Hepatitis A virus; D006801:Humans; D006814:Hungary; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M; D007223:Infant; D008... | Orvosi hetilap | 2,007 | D007075:Immunoglobulin M |
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