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Prognostic significance of let-7b expression in breast cancer and correlation to its target gene of BSG expression. | Let-7 microRNAs (miRNAs) are found in a wide range of species, and alterations of let-7 miRNA family member expression levels in humans are associated with various types of cancer. However, few researchers have reported alterations in let-7b levels in breast cancer (BC). Specifically, the use of altered let-7 expressio... | 10.1007/s12032-013-0773-7 | 24,264,599 | D000328:Adult; D000368:Aged; D051926:Basigin; D014408:Biomarkers, Tumor; D001941:Breast Diseases; D001943:Breast Neoplasms; D004076:Digoxigenin; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D008875:Middle Aged; D015345:Oligonucleotide Pr... | Medical oncology (Northwood, London, England) | 2,014 | C497886:BSG protein, human; D014408:Biomarkers, Tumor; D035683:MicroRNAs; D015345:Oligonucleotide Probes; C487931:mirnlet7 microRNA, human; D051926:Basigin; D004076:Digoxigenin |
Navigation-Assisted Minimally Invasive Surgery Deformity Correction. | Surgical correction of deformity is a complex endeavor. Although more traditional, open techniques remain important, minimally invasive surgery (MIS) techniques have been increasingly studied as an alternative approach. In particular, the circumferential MIS approach, which may incorporate a lateral/anterior as well as... | 10.1016/j.nec.2018.03.002 | 29,933,811 | D006801:Humans; D019060:Minimally Invasive Surgical Procedures; D013121:Spinal Curvatures; D013123:Spinal Fusion; D016896:Treatment Outcome | Neurosurgery clinics of North America | 2,018 | |
Alaska--warning up to managed care. | Alaskan healthcare providers are beginning to feel the heat from healthcare costs. The result is a move toward managed care and increased integration and collaboration. But the state's fragmented healthcare system is slowing progress. | 10,138,247 | D000413:Alaska; D002391:Catchment Area, Health; D003151:Community Health Centers; D003695:Delivery of Health Care; D004465:Economic Competition; D006764:Hospitals, Community; D006768:Hospitals, Federal; D006787:Hospitals, Veterans; D007348:Insurance, Health; D008329:Managed Care Programs; D008484:Medicaid; D013221:Stat... | Modern healthcare | 1,994 | ||
Spectrum, management and outcomes of structural and functional uropathies in children attending a tertiary care center in Karachi; Pakistan. | Causes and outcomes of children diagnosed with hydronephrosis in resource-limited countries with a low utilization of antenatal ultrasonography remain unexplored. We performed a retrospective, crosssectional study of all paediatric patients diagnosed with hydronephrosis and managed at a tertiary care center in Karachi,... | 30,410,153 | D002675:Child, Preschool; D003430:Cross-Sectional Studies; D019468:Disease Management; D005260:Female; D006801:Humans; D006869:Hydronephrosis; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010154:Pakistan; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014463:Ultrasonography... | JPMA. The Journal of the Pakistan Medical Association | 2,018 | ||
[Direct and indirect diabetes costs in the world]. | Diabetes is becoming one of the major public health problems because a great proportion of the healthcare expenditure has been spent on the treatment of its associated morbidity and mortality. Diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital ... | 14,764,977 | D000328:Adult; D000367:Age Factors; D001459:Bangladesh; D002648:Child; D017281:Cost of Illness; D003922:Diabetes Mellitus, Type 1; D004739:England; D005060:Europe; D005260:Female; D017048:Health Care Costs; D005102:Health Expenditures; D006801:Humans; D008097:Lithuania; D008297:Male; D008875:Middle Aged; D011788:Qualit... | Medicina (Kaunas, Lithuania) | 2,004 | ||
Dose optimization of intra-operative high dose rate interstitial brachytherapy implants for soft tissue sarcoma. | OBJECTIVE
A three dimensional (3D) image-based dosimetric study to quantitatively compare geometric vs. dose-point optimization in combination with graphical optimization for interstitial brachytherapy of soft tissue sarcoma (STS).
MATERIALS AND METHODS
Fifteen consecutive STS patients, treated with intra-operative, ... | 10.4103/0973-1482.59893 | 20,160,356 | D001918:Brachytherapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011880:Radiotherapy Planning, Computer-Assisted; D012509:Sarcoma; D012983:Soft Tissue Neoplasms | Journal of cancer research and therapeutics | 2,009 | |
[Experimental studies of intrahepatic portal vein embolization and embolic materials]. | The author has developed the intrahepatic portal vein embolization for the treatment of liver cancers. The purposes of this new method are 1) extension of indications for surgery by causing compensatory hypertrophy of non-embolized lobe, 2) prevention of dissemination of the tumor cells via the portal vein, 3) causing ... | 2,552,401 | D000818:Animals; D004285:Dogs; D004621:Embolization, Therapeutic; D005337:Fibrin; D007459:Iodized Oil; D008114:Liver Neoplasms, Experimental; D011169:Portal Vein; D013917:Thrombin | Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica | 1,989 | D007459:Iodized Oil; D005337:Fibrin; D013917:Thrombin | |
Poisson-Boltzmann analysis of the lambda repressor-operator interaction. | A theoretical study of the ion atmosphere contribution to the binding free energy of the lambda repressor-operator complex is presented. The finite-difference form of the Poisson-Boltzmann equation was solved to calculate the electrostatic interaction energy of the amino-terminal domain of the lambda repressor with a 9... | 10.1016/S0006-3495(92)81723-X | 1,477,279 | D010582:Bacteriophage lambda; D001483:Base Sequence; D055592:Biophysical Phenomena; D001703:Biophysics; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D004563:Electrochemistry; D008954:Models, Biological; D008969:Molecular Sequence Data; D009875:Operator Regions, Genetic; D012097:Repressor Proteins; D013816:Thermody... | Biophysical journal | 1,992 | D004279:DNA, Viral; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins |
Infestation of sheep dung by nematophagous fungi and implications for the control of free-living stages of gastro-intestinal nematodes. | A field trial was conducted to assess the rate at which dung becomes infested by fungi which parasitise nematodes (nematophagous fungi) after deposition. Sheep dung was placed on field plots of bare ground, ryegrass (Lolium perenne), browntop (Agrostis capillaris) and white clover (Trifolium repens) in summer (February... | 10.1016/s0304-4017(96)01149-1 | 9,211,650 | D000818:Animals; D004064:Digestive System; D005243:Feces; D003904:Mitosporic Fungi; D009348:Nematoda; D009349:Nematode Infections; D009520:New Zealand; D012756:Sheep; D012757:Sheep Diseases | Veterinary parasitology | 1,997 | |
Immunonephelometric assay for urinary total protein and albumin in mice. | A quantitative immunonephelometric assay for measuring total protein and albumin in mouse urine has been developed. Antisera to whole mouse sera or to mouse albumin was added to aliquots of urine and the antigen-antibody complexes formed were measured by laser nephelometry. Sample volumes were small (20 microliters) an... | 504,793 | D000419:Albuminuria; D000818:Animals; D000906:Antibodies; D003404:Creatinine; D005260:Female; D007700:Kinetics; D008722:Methods; D051379:Mice; D008809:Mice, Inbred C3H; D009391:Nephelometry and Turbidimetry; D011507:Proteinuria; D012756:Sheep; D013997:Time Factors | Research communications in chemical pathology and pharmacology | 1,979 | D000906:Antibodies; D003404:Creatinine | |
The Effects of Problem Drinking and Sexual Risk Among Mexican Migrant Workers on Their Community of Origin. | Although the financial remittances sent by male Mexican migrant workers residing in the United States can result in higher standards of living for their families and home communities, out-migration may lead to increased migrant problem drinking and sexual risk behaviors, which may in turn impact these same communities ... | 10.17730/humo.68.3.673vg846646w1617 | 20,169,008 | Human organization | 2,009 | ||
Adherence to Enhanced Recovery Protocols in NSQIP and Association With Colectomy Outcomes. | OBJECTIVE
To evaluate the effect of protocol adherence on length of stay (LOS) and recovery-specific outcomes after colectomy.
BACKGROUND
Enhanced recovery protocols (ERPs) may decrease postoperative morbidity and LOS; however, the effect of overall protocol adherence remains unclear.
METHODS
Using American College... | 10.1097/SLA.0000000000002566 | 29,064,887 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002985:Clinical Protocols; D003082:Colectomy; D000080482:Enhanced Recovery After Surgery; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, ... | Annals of surgery | 2,019 | |
Polymorphism analysis of csd gene in six Apis mellifera subspecies. | The complementary sex determination (csd) gene is the primary gene determining the gender of honey bees (Apis spp). In this study we analyzed the polymorphism of csd gene in six Apis mellifera subspecies. The genomic region 3 of csd gene in these six A. mellifera was cloned, and identified. A total of 79 haplotypes wer... | 10.1007/s11033-011-1069-7 | 21,687,972 | D000818:Animals; D001483:Base Sequence; D001516:Bees; D002681:China; D016000:Cluster Analysis; D017931:DNA Primers; D005796:Genes; D005828:Genetics, Population; D006239:Haplotypes; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D019849:Sex Determinatio... | Molecular biology reports | 2,012 | D017931:DNA Primers |
Cocaine regulation of brain preprothyrotropin-releasing hormone mRNA. | Clinical and preclinical evidence supports a possible role for thyrotropin-releasing hormone (TRH) in cocaine action. However, the interaction between cocaine and TRH has not been directly examined. In the following report we describe a solution hybridization RNase protection assay that can sensitively detect mRNA for ... | 10.1111/j.1471-4159.1993.tb03267.x | 8,436,966 | D000818:Animals; D015152:Blotting, Northern; D001921:Brain; D003042:Cocaine; D007267:Injections; D008297:Male; D011498:Protein Precursors; D012333:RNA, Messenger; D051381:Rats; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors; D014018:Tissue Distribution | Journal of neurochemistry | 1,993 | D011498:Protein Precursors; D012333:RNA, Messenger; C063596:prepro-thyrotropin-releasing hormone; D013973:Thyrotropin-Releasing Hormone; D003042:Cocaine |
Determination of Antiepileptic Drugs Using Dried Saliva Spots. | The present work describes the development and validation of an analytical method for the determination of the antiepileptic drugs (AEDs) phenytoin, phenobarbital, carbamazepine and its active metabolite carbamazepine-10,11-epoxide, in oral fluid using liquid chromatography coupled to a diode array detector. Correlatio... | 10.1093/jat/bky064 | 30,192,957 | D000927:Anticonvulsants; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003890:Desiccation; D016903:Drug Monitoring; D006801:Humans; D057230:Limit of Detection; D012015:Reference Standards; D015203:Reproducibility of Results; D012463:Saliva; D013048:Specimen Handling; D013057:Spectrum Analysis | Journal of analytical toxicology | 2,019 | D000927:Anticonvulsants |
Synergistic effect of ClO4- and Sr2+ adsorption on alginate-encapsulated organo-montmorillonite beads: Implication for radionuclide immobilization. | Perchlorate (ClO4-) and pertechnetate (TcO4-) exhibit similar adsorption characteristics on alkyl quaternary ammonium-modified montmorillonite (Mt), and 99mTcO4- normally coexists with 90Sr2+ in radionuclide-contaminated water. In this study, hexadecyl pyridinium (HDPy)-modified Mt (OMt) was encapsulated in alginate be... | 10.1016/j.jcis.2019.10.049 | 31,635,881 | Journal of colloid and interface science | 2,020 | ||
Laboratory tests for neuroendocrine tumours. | Neuroendocrine tumours (NETs) often have a good prognosis and have peculiar biological characteristics, among which the ability to produce and release biologically active substances. Hypersecretion of hormones, biogenic amines or growth factors often cause severe syndromes that are very debilitating. Now sensitive assa... | 10,932,599 | D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D004701:Endocrine Gland Neoplasms; D005770:Gastrointestinal Neoplasms; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D018358:Neuroendocrine Tumors; D010190:Pancreatic Neoplasms; D011471:Prostatic Neoplasms | The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) | 2,000 | D014408:Biomarkers, Tumor | |
Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines. | Specific gene promoter DNA methylation is becoming a powerful epigenetic biomarker in cancer diagnostics. Five genes (CDH1, CDKN2Ap16, RASSF1A, TERT, and WT1) were selected based on their frequently published potential as epigenetic markers. Diagnostic promoter methylation assays were generated based on bisulfite-conve... | 10.3390/ijms21134595 | 32,605,217 | D000368:Aged; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015820:Cadherins; D002289:Carcinoma, Non-Small-Cell Lung; D019175:DNA Methylation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011401:Promote... | International journal of molecular sciences | 2,020 | D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins |
Mutable yeast prion variants are stabilized by a defective Hsp104 chaperone. | Gorkovskiy et al. observed that many [PSI+ ] prion isolates, obtained in yeast with the mutant Hsp104T160M chaperone, propagate poorly in wild-type cells and suggested that Hsp104 is part of the cellular anti-prion system, curing many nascent [PSI+ ] variants. Here, we argue that the concept may require reassessment. W... | 10.1111/mmi.14643 | 33,190,361 | D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D010454:Peptide Termination Factors; D011328:Prions; D017510:Protein Folding; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D017384:Sequence Deletion | Molecular microbiology | 2,021 | D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D010454:Peptide Termination Factors; D011328:Prions; C068068:SUP35 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C070972:HsP104 protein, S cerevisiae |
Femtosecond Laser Assisted 3D Etching Using Inorganic-Organic Etchant. | Selective laser etching (SLE) is a technique that allows the fabrication of arbitrarily shaped glass micro-objects. In this work, we show how the capabilities of this technology can be improved in terms of selectivity and etch rate by applying an etchant solution based on a Potassium Hydroxide, water, and isopropanol m... | 10.3390/ma15082817 | 35,454,510 | Materials (Basel, Switzerland) | 2,022 | ||
Surviving social assistance: 12-month prevalence of depression in sole-support parents receiving social assistance. | BACKGROUND
Although it is generally recognized that poverty and depression can coexist among single parents receiving social assistance, there is insufficient research on this topic. The goals of this study therefore were to investigate the prevalence, correlates and health care expenditures associated with depression ... | 9,559,013 | D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000385:Aid to Families with Dependent Children; D002648:Child; D002675:Child, Preschool; D003866:Depressive Disorder; D005260:Female; D005382:Financing, Personal; D006801:Humans; D007223:Infant; D008297:Male; D009864:Ontario; D015995:Prevalence; D01... | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 1,998 | ||
Paraneoplastic neurological disorders. | The article provides an overview on the diagnosis and pathogenesis of paraneoplastic neurological disorders (PNDs), and subsequently the current therapeutic strategies in these patients. PNDs are nervous system dysfunctions in cancer patients, which are not due to a local effect of the tumor or its metastases. Most of ... | 10.1586/ern.10.134 | 20,925,471 | D001323:Autoantibodies; D002493:Central Nervous System Diseases; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D009419:Nerve Tissue Proteins; D009422:Nervous System Diseases; D020364:Paraneoplastic Polyneuropathy; D020361:Paraneoplastic Syndromes, Nervous System | Expert review of neurotherapeutics | 2,010 | D001323:Autoantibodies; D009419:Nerve Tissue Proteins |
Implementing Better Standard Instruments for Detecting Cirrhosis in Hepatitis C Patients. | An increasing number of hepatitis C diagnoses in the younger population could partly be due to the rising opioid epidemic and intravenous drug use. Using hepatic venous portal gradient (HVPG) and liver stiffness tests, this study investigates better early diagnostic markers in identifying cirrhosis-related complication... | 10.7759/cureus.44597 | 37,795,065 | Cureus | 2,023 | ||
Should Exercises be Painful or not? Effects on Clinical and Experimental Pain in Individuals with Shoulder Pain. | Exercise can reduce pain, however the effect of painful versus non-painful exercises is uncertain. The primary aim of this randomized crossover study was to compare the effect of painful versus nonpainful isometric shoulder exercises on pain intensity after exercise in individuals with rotator cuff-related shoulder pai... | 10.1016/j.jpain.2021.03.153 | 33,887,445 | D000328:Adult; D000698:Analgesia; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D017288:Pain Threshold; D017006:Rotator Cuff; D020069:Shoulder Pain | The journal of pain | 2,021 | |
A comparative cradle-to-gate life cycle assessment of three cotton stalk waste sustainable applications. | This paper presents a novel approach to utilizing agricultural waste. It compares three different applications for cotton stalks: fabrication of wood composites, bioethanol production, and biogas cradle-to-gate Life cycle assessment production processes. Cotton cultivation generates a lot of debris, mostly cotton stalk... | 10.1038/s41598-023-47817-y | 38,012,270 | D006801:Humans; D000818:Animals; D017753:Ecosystem; D056804:Biofuels; D002245:Carbon Dioxide; D058572:Carbon Footprint; D008018:Life Cycle Stages | Scientific reports | 2,023 | D056804:Biofuels; D002245:Carbon Dioxide |
[Specifics in pediatric arterial cerebral infarctions]. | Despite the number of potential causes, most children with ischemic cerebrovascular disease are classified into a few major categories: 1) cardioembolic stroke; 2) moyamoya syndrome; 3) complication(s) connected with systemic disease, with a known risk of a cerebrovascular event; 4) cervicocephalic arterial dissection;... | 10.1016/s0929-693x(00)00200-1 | 11,270,256 | D000367:Age Factors; D001167:Arteritis; D020215:Carotid Artery, Internal, Dissection; D002533:Cerebral Angiography; D002544:Cerebral Infarction; D002648:Child; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009072:Moyamoya Disease; D011159:Population Surveillance; D012008:Recurrence; ... | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | 2,001 | |
Paroxysmal Sympathetic Hyperactivity in Stroke. | OBJECTIVE
Paroxysmal sympathetic hyperactivity (PSH) is a life-threatening neurological emergency associated with severe brain injury. Stroke-related PSH, particularly post-aneurysmal subarachnoid hemorrhage (aSAH) PSH, has been relatively understudied and is often misdiagnosed as an aSAH-related hyperadrenergic crisis... | 10.1016/j.wneu.2023.07.002 | 37,423,330 | World neurosurgery | 2,023 | ||
Interactions of lesion detectability and size across single-slice DBT and 3D DBT. | Three dimensional image modalities introduce a new paradigm for visual search requiring visual exploration of a larger search space than 2D imaging modalities. The large number of slices in the 3D volumes and the limited reading times make it difficult for radiologists to explore thoroughly by fixating with their high ... | 10.1117/12.2293873 | 32,435,080 | Proceedings of SPIE--the International Society for Optical Engineering | 2,018 | ||
Feeding laying hens with lactobacilli improves internal egg quality and animal health. | Feeding animals with lactobacilli strains is a biotechnological strategy to improve production, food quality, and animal health. Thus, this study aimed to select new lactic acid bacteria (LAB) able to improve laying hens health and egg production. Forty Bovans White layers (two days old) were randomly divided into four... | 10.1007/s11274-023-03820-z | 37,925,366 | D000818:Animals; D005260:Female; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D002645:Chickens; D004032:Diet; D019587:Dietary Supplements; D056546:Lactobacillales; D007778:Lactobacillus | World journal of microbiology & biotechnology | 2,023 | |
Cor triatriatum dexter in an adult diagnosed by transesophageal echocardiography: a case report. | Cor triatriatum dexter is a rare congenital heart malformation in which a persistent right sinus venosus valve divides the right atrium into two chambers. Before echocardiography, this anomaly has been rarely diagnosed before surgery or death. This is a case of cor triatriatum dexter in an adult with lifelong exertiona... | 10.1016/s0894-7317(05)80025-2 | 8,611,301 | D003310:Cor Triatriatum; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D006344:Heart Septal Defects, Atrial; D006801:Humans; D008297:Male; D008875:Middle Aged | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography | 1,995 | |
Does impedance cardiography reliably estimate left ventricular ejection fraction? | OBJECTIVE
The objective of our study was to evaluate impedance cardiography (IMP) as a noninvasive method to determine the left ventricular ejection fraction (LVEF). METHODS. A total of 24 patients, 8 men and 16 women, aged 45.0 +/- 12.9 years, participated in the study. They used cardiotoxic chemotherapeutic drugs or ... | 10.1007/BF02025304 | 8,732,810 | D000903:Antibiotics, Antineoplastic; D002307:Cardiography, Impedance; D003971:Diastole; D004317:Doxorubicin; D004562:Electrocardiography; D005260:Female; D006321:Heart; D006333:Heart Failure; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015635:Radionuclide Ventriculogra... | Journal of clinical monitoring | 1,996 | D000903:Antibiotics, Antineoplastic; D014003:Tin Polyphosphates; D004317:Doxorubicin; D013670:Sodium Pertechnetate Tc 99m |
Benign cystic mesothelioma of the peritoneum: report of a case. | A 36-year-old multiparous woman presented with the chief complaint of mass and fullness over the lower abdomen for the previous 3 months. Abdominal ultrasound revealed a uniloculated, thin-walled cyst attached to the peritoneal surface of the right lower abdomen. The cyst was surgically excised and confirmed to be cyst... | 1,977,865 | D000328:Adult; D003560:Cysts; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma; D010534:Peritoneal Neoplasms; D014463:Ultrasonography | Journal of the Formosan Medical Association = Taiwan yi zhi | 1,990 | ||
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. | Presenilins 1 and 2 (PS1 and 2) are the catalytic subunits of γ-secretase, a multiprotein protease that cleaves amyloid protein precursor and other type I transmembrane proteins. Previous studies with mouse models or cells have indicated differences in PS1 and PS2 functions. We have recently reported that clinical γ-se... | 10.1074/jbc.RA119.008041 | 31,167,792 | D000544:Alzheimer Disease; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D064113:CRISPR-Cas Systems; D055785:Gene Knockdown Techniques; D057809:HEK293 Cells; D006801:Humans; D006868:Hydrolysis; D051379:Mice; D053764:Presenilin-1; D053766:Presenilin-2; D013379:Substrate Specificity | The Journal of biological chemistry | 2,019 | C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D053829:Amyloid Precursor Protein Secretases |
The adoption of climate-smart agriculture to address wildfires in the Maya Golden Landscape of Belize: Smallholder farmers' perceptions. | Ecosystems around the globe are enduring wildfires with greater frequency, intensity, and severity and this trend is projected to continue as a result of climate change. Climate-smart agriculture (CSA) has been proposed as a strategy to prevent wildfires and mitigate climate change impacts; however, it remains poorly u... | 10.1016/j.jenvman.2023.118562 | 37,423,190 | D006801:Humans; D000075923:Wildfires; D017753:Ecosystem; D000067565:Farmers; D001531:Belize; D000383:Agriculture; D005390:Fires; D057231:Climate Change | Journal of environmental management | 2,023 | |
Enabling fast ionic transport in CeO2-La1-2BaBiFeO3 nanocomposite electrolyte for low temperature solid oxide fuel cell application. | Recent studies indicate that electrolyte ionic conductivity plays a pivotal role in reducing the operating temperature of solid oxide fuel cells (SOFCs). In this regard, nanocomposite electrolytes have drawn significant attention owing to their enhanced ionic conductivity and fast ionic transport. In this study, we fab... | 10.1039/d3ra01698f | 37,435,385 | RSC advances | 2,023 | ||
Processing of procarboxypeptidase A and other zymogens in murine mast cells. | By cDNA sequence analyses the proteases found within the secretory granules of immune/inflammatory cells appear to be translated initially as zymogens, but by amino-terminal sequencing they are stored within the granules in an active form. We now show that murine mast cell carboxypeptidase A (MC-CPA) is produced in a z... | 7,929,294 | D000595:Amino Acid Sequence; D000818:Animals; D002268:Carboxypeptidases; D043422:Carboxypeptidases A; D002401:Cathepsin B; D020789:Cathepsin C; D002478:Cells, Cultured; D053818:Chymases; D003978:Diazomethane; D004151:Dipeptides; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D004792:Enzyme Precursors; D00545... | The Journal of biological chemistry | 1,994 | D004151:Dipeptides; D004792:Enzyme Precursors; D011994:Recombinant Proteins; C509190:Tpsb2 protein, mouse; C089960:glycylphenylalanine diazomethyl ketone; D003978:Diazomethane; D002268:Carboxypeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020789:Cathepsin C; D043422:Carboxypeptidases A; D012697:... | |
[Ecdysten in the treatment of giardiasis]. | The drug ecdisten as tablets is the natural compound ecdisteron was extracted from Rhaponticum carthamoides (Willd.) Jljin. Ecdisten was tested in the treatment of 32 and 3 patients with persistent and acute giardiasis, respectively. A ten-day course of ecdisten, 5 mg 3 or 4 times a day, resulted in a clinical and para... | 12,224,262 | D000284:Administration, Oral; D000328:Adult; D000981:Antiprotozoal Agents; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004334:Drug Administration Schedule; D005260:Female; D005873:Giardiasis; D006801:Humans; D008297:Male; D010936:Plant Extracts; D013256:Steroids | Meditsinskaia parazitologiia i parazitarnye bolezni | 2,002 | D000981:Antiprotozoal Agents; D010936:Plant Extracts; D013256:Steroids; C088647:ecdystene | |
Use of gesture development in profiling children's prelinguistic communication skills. | PURPOSE
Comparing children's skills across and within domains of development has become a standard in providing early intervention services. Profiling a child's strengths and challenges can help in making decisions regarding eligibility, diagnosis, and intervention. Profiling is particularly important for children who ... | 10.1044/1058-0360(2008/07-0041) | 19,029,535 | D002663:Child Language; D002675:Child, Preschool; D003147:Communication Disorders; D002658:Developmental Disabilities; D005868:Gestures; D006801:Humans; D007223:Infant; D008607:Intellectual Disability; D007398:Interpersonal Relations; D007807:Language Tests; D013060:Speech | American journal of speech-language pathology | 2,009 | |
Synthesis and Properties of Energy-Rich Methanofullerenes Containing Norbornadiene and Quadricyclane Moieties. | The energy-rich methanofullerenes were synthesized for the first time by the reaction of fullerene C60 with mono- and bisquadricyclane esters of malonic acid. The C-C bond cleavage in the quadricyclane moieties of new hybrid molecules takes place in the presence of catalytic amounts of Cu, Pd, and Pt salts or complexes... | 10.1021/acs.joc.8b00119 | 29,533,625 | The Journal of organic chemistry | 2,018 | ||
Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis. | We isolated a cDNA clone encoding a novel SRY-type HMG box (Sox) protein, designated Sox24, from a rainbow trout ovary cDNA library. On the basis of the HMG box amino acid sequence, Sox24 can be categorized into the same subgroup of Sox proteins as SOX4, SOX11, and SOX22. The proteins in this group also share a highly ... | 10.1016/s0378-1119(98)00100-0 | 9,602,142 | D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004247:DNA; D018076:DNA, Complementary; D005260:Female; D029941:Fish Proteins; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D005796:Genes; D006609:High Mobility Group Proteins; D008969:Molecular Sequence Data; D017686:O... | Gene | 1,998 | D018076:DNA, Complementary; D029941:Fish Proteins; D006609:High Mobility Group Proteins; D012333:RNA, Messenger; C112950:RtSox24 protein, Oncorhynchus mykiss; D014157:Transcription Factors; D004247:DNA |
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer. | BACKGROUND
Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and wh... | 10.1002/hed.25459 | 30,549,356 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms; D008297:Male; D020784:Matrix Metalloproteinase 8; D008875:Middle Aged; D030361:Papillomavirus Infections; D0... | Head & neck | 2,019 | D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8 |
The Influence of ESG Ratings On Idiosyncratic Stock Risk: The Unrated, the Good, the Bad, and the Sinners. | This study analyzes whether stocks of companies with environmental social governance (ESG) rating show lower idiosyncratic risk. The main analysis covers 898,757 company-month observations of US stocks in the period from 1991 to 2018 and controls for stocks' exposure to liquidity, mispricing, innovations in volatility ... | 10.1007/s41471-023-00155-1 | 36,844,611 | Schmalenbachs Zeitschrift fur betriebswirtschaftliche Forschung = Schmalenbach journal of business research | 2,023 | ||
Day-to-day deviations in sleep parameters and biological aging: Findings from the NHANES 2011-2014. | OBJECTIVES
The majority of the previous research has focused on the impact of average sleep parameters on longevity. In this study, we aimed to investigate the associations of day-to-day deviations in sleep parameters with biological ages among 6052 adults participating in the 2011-2014 waves of the US National Health ... | 10.1016/j.sleh.2023.07.018 | 37,648,648 | Sleep health | 2,023 | ||
Minimally Invasive Cell-Free Human Embryo Aneuploidy Testing (miPGT-A) Utilizing Combined Spent Embryo Culture Medium and Blastocoel Fluid -Towards Development of a Clinical Assay. | Preimplantation genetic testing for aneuploidies (PGT-A) using trophectoderm (TE) biopsy samples is labour intensive, invasive, and subject to sampling bias. In this study, we report on the efficacy and factors affecting accuracy of a technique we pioneered for minimally invasive preimplantation genetic testing for ane... | 10.1038/s41598-020-64335-3 | 32,350,403 | D000782:Aneuploidy; D001755:Blastocyst; D000073888:Cell-Free Nucleic Acids; D003470:Culture Media; D004622:Embryo, Mammalian; D006801:Humans; D008297:Male; D019836:Preimplantation Diagnosis | Scientific reports | 2,020 | D000073888:Cell-Free Nucleic Acids; D003470:Culture Media |
The distribution and functional relevance analysis of runs of homozygosity (ROHs) in Chinese Han female population. | Extended homozygosity is a genomic region in which the copies inherited from parents are identical, and has obvious inter-individual differences in length and frequency. Runs of homozygosity (ROHs), regarded as a type of structure variations, may have potential capacity in regulating gene transcription. To learn more a... | 10.1007/s00438-017-1378-1 | 28,980,070 | D044466:Asian People; D002681:China; D002877:Chromosomes, Human; D005260:Female; D015894:Genome, Human; D006720:Homozygote; D006801:Humans; D007963:Leukocytes, Mononuclear; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci | Molecular genetics and genomics : MGG | 2,018 | |
Molecular variability of Czech plum pox virus isolates. | Seventy-two Czech plum pox virus (PPV) isolates from different hosts were tested by double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). In addition, the coat protein mobility and the RsaI restriction fragment length polymorphism (RFLP) pattern of reverse transcription-polymerase chain reaction-(RT-P... | 10,073,232 | D000911:Antibodies, Monoclonal; D015153:Blotting, Western; D018153:Czech Republic; D004797:Enzyme-Linked Immunosorbent Assay; D010935:Plant Diseases; D017801:Plum Pox Virus; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012703:Serotyping | Acta virologica | 1,998 | D000911:Antibodies, Monoclonal | |
Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function. | Matrix metalloproteinases (MMPs) have recently become interesting as potential anticancer drugs. RO-28-2653 is a promising compound because of its antimetastatic and antiangiogenic activities. Due to the structural similarity of RO-28-2653 to mitochondriotoxic agents, speculation has arisen that this substance might im... | 10.1016/s0006-2952(01)00867-x | 11,992,641 | D000818:Animals; D004791:Enzyme Inhibitors; D008297:Male; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D008929:Mitochondria, Heart; D010879:Piperazines; D011743:Pyrimidines; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration | Biochemical pharmacology | 2,002 | D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D010879:Piperazines; D011743:Pyrimidines; C453902:Ro 28-2653; D020782:Matrix Metalloproteinases |
TNF plays an essential role in tumor regression after adoptive transfer of perforin/IFN-gamma double knockout effector T cells. | We have recently shown that effector T cells (T(E)) lacking either perforin or IFN-gamma are highly effective mediators of tumor regression. To rule out compensation by either mechanism, T(E) deficient in both perforin and IFN-gamma (perforin knockout (PKO)/IFN-gamma knockout (GKO)) were generated. The adoptive transfe... | 10.4049/jimmunol.170.4.2004 | 12,574,370 | D019264:Adoptive Transfer; D000818:Animals; D015703:Antigens, CD; D001667:Binding, Competitive; D019496:Cancer Vaccines; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D018984:Epitopes, T-Lymphocyte; D007141:Immunoglobulin Fc Fragments; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous;... | Journal of immunology (Baltimore, Md. : 1950) | 2,003 | D015703:Antigens, CD; D019496:Cancer Vaccines; D018984:Epitopes, T-Lymphocyte; D007141:Immunoglobulin Fc Fragments; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D011993:Recombinant Fusion Proteins; D... |
Oxygen uptake during the mixing of saliva with ascorbic acid under acidic conditions: possibility of its occurrence in the stomach. | Human saliva, which contains nitrite, is normally mixed with gastric juice, which contains ascorbic acid (AA). When saliva was mixed with an acidic buffer in the presence of 0.1 mM AA, rapid nitric oxide formation and oxygen uptake were observed. The oxygen uptake was due to the oxidation of nitric oxide, which was for... | 10.1016/s0014-5793(03)00820-2 | 12,935,887 | D000143:Acids; D001205:Ascorbic Acid; D002498:Centrifugation; D005750:Gastric Juice; D005753:Gastric Mucosa; D006801:Humans; D009569:Nitric Oxide; D010084:Oxidation-Reduction; D010100:Oxygen; D010101:Oxygen Consumption; D012463:Saliva; D013861:Thiocyanates; D013997:Time Factors | FEBS letters | 2,003 | D000143:Acids; D013861:Thiocyanates; D009569:Nitric Oxide; D001205:Ascorbic Acid; D010100:Oxygen |
Replacement of ruptured chordae tendineae of the mitral valve with autologous pericardial chordae. | Severe mitral regurgitation owing to rupture of chordae tendineae has been repaired in 10 patients by construction of new chordae from autologous pericardium. The site of rupture was the posterior leaflet in eight patients, the anterior leaflet in one patient, and both leaflets in one patient. Cardiac catheterization d... | 351,296 | D000368:Aged; D000790:Angiocardiography; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002815:Chordae Tendineae; D005260:Female; D005500:Follow-Up Studies; D006341:Heart Rupture; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency; D010496:Pericardium; D011652:Pulmonary Cir... | The Journal of thoracic and cardiovascular surgery | 1,978 | ||
A low-cost flow cytometric assay for the detection and quantification of apoptosis using an anionic halogenated fluorescein dye. | We describe here a technical improvement of an established colorimetric method used to detect and measure the occurrence of apoptosis in mammalian cells during in vitro cell culture. This assay uses an anionic halogenated fluorescein dye that is taken up by apoptotic cells at the stage of phosphatidylserine externaliza... | 10.2144/000112908 | 18,778,255 | D017304:Annexin A5; D017209:Apoptosis; D001681:Biological Assay; D045744:Cell Line, Tumor; D004396:Coloring Agents; D005434:Flow Cytometry; D019793:Fluorescein; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D012516:Osteosarcoma; D015203:Reproducibility of Results | BioTechniques | 2,008 | D017304:Annexin A5; D004396:Coloring Agents; D005456:Fluorescent Dyes; D019793:Fluorescein |
Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escape. | Infection with high-risk types of human papillomavirus (HPV) can cause the development of malignant tumors. To study mechanisms responsible for immune escape of tumor cells infected with HPV16, we previously used mouse oncogenic TC-1 cells producing HPV16 E6 and E7 oncoproteins to derive TC-1 clones resistant to immuni... | 10.1007/s00262-007-0418-9 | 17,962,940 | D000818:Animals; D000951:Antigens, Neoplasm; D000939:Epitopes; D005260:Female; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D006801:Humans; D016056:Immunodominant Epitopes; D007167:Immunotherapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009369:Neoplasms; D015513:Oncogene Proteins; ... | Cancer immunology, immunotherapy : CII | 2,008 | D000951:Antigens, Neoplasm; D000939:Epitopes; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D016056:Immunodominant Epitopes; D015513:Oncogene Proteins; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16 |
Colloid milium of the oral cavity: a rare presentation. | Colloid milium (CM) is a rare condition characterized by the presence of multiple dome-shaped amber- or flesh-colored papules developing on sun-exposed skin. It is a degenerative condition linked to excessive sun exposure and possibly exposure to petroleum products and hydroquinone. The origin of the colloid deposition... | 10.1016/j.tripleo.2007.11.032 | 18,329,566 | D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005148:Facial Dermatoses; D006801:Humans; D008297:Male; D009059:Mouth Diseases; D010787:Photosensitivity Disorders; D017444:Skin Diseases, Papulosquamous; D013472:Sunlight | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics | 2,008 | |
Ion-coupling determinants of Na+-driven and H+-driven flagellar motors. | The bacterial flagellar motor is a tiny molecular machine that uses a transmembrane flux of H(+) or Na(+) ions to drive flagellar rotation. In proton-driven motors, the membrane proteins MotA and MotB interact via their transmembrane regions to form a proton channel. The sodium-driven motors that power the polar flagel... | 10.1016/s0022-2836(03)00096-2 | 12,628,250 | D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004926:Escherichia coli; D005407:Flagella; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D008565:Membrane Proteins; D020409:Molecular Motor Proteins; D008969:Molecular Sequence Data; D010957:Plasmids; D017386:Se... | Journal of molecular biology | 2,003 | D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D008565:Membrane Proteins; D020409:Molecular Motor Proteins; C063010:MotA protein, Bacteria; C064779:MotB protein, Bacteria; C089633:MotX protein, bacteria; C088135:MotY protein, Vibrio; C107540:PomA protein, Vibrio; C107541:PomB protein, Vibrio; D0... |
Will lowering population levels of serum cholesterol affect total mortality? Expectations from the Honolulu Heart Program. | Major campaigns now underway to reduce the serum cholesterol levels of entire national populations have not given serious consideration to the high rates of noncardiovascular disease and death associated with low cholesterol levels (less than 190 mg/dl). To explore this problem, the relationships between serum choleste... | 10.1016/0895-4356(92)90034-k | 1,569,429 | D000368:Aged; D001213:Asian; D002423:Cause of Death; D002543:Cerebral Hemorrhage; D002784:Cholesterol; D015331:Cohort Studies; D003198:Computer Simulation; D003327:Coronary Disease; D006801:Humans; D008107:Liver Diseases; D008173:Lung Diseases, Obstructive; D008297:Male; D009026:Mortality; D009369:Neoplasms; D016016:Pr... | Journal of clinical epidemiology | 1,992 | D002784:Cholesterol |
Identification of hot and cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts. | The organization of genomic sequences is dynamic and undergoes change during the process of evolution. Many of the variations arise spontaneously and the observed genomic changes can either be distributed uniformly throughout the genome or be preferentially localized to some regions (hot spots) compared to others. Conv... | 10.1038/srep00297 | 22,389,766 | D003080:Cold Temperature; D016680:Genome, Bacterial; D006358:Hot Temperature; D009169:Mycobacterium tuberculosis; D020641:Polymorphism, Single Nucleotide | Scientific reports | 2,012 | |
Lung function in the absence of respiratory symptoms in overweight children and adolescents. | OBJECTIVE
To describe lung function findings in overweight children and adolescents without respiratory disease.
METHODS
This was a cross-sectional study involving male and female overweight children and adolescents in the 8-18 year age bracket, without respiratory disease. All of the participants underwent anthropom... | 24,831,397 | D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight; D012123:Pulmonary Ventilation; D012120:Respiration Disorders; D012129:Respiratory Function Tests; D055105:Waist Circumference | Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia | 2,014 | ||
Incidence of epicardial connections between the right pulmonary vein carina and right atrium during catheter ablation of atrial fibrillation: A comparison between the conventional method and unipolar signal modification. | BACKGROUND
When performing an electrical isolation of ipsilateral pulmonary veins (PVs) for atrial fibrillation, physicians often need additional radiofrequency (RF) ablation in the carina region between the superior and inferior PVs to achieve a right PV isolation because of intercaval bundles between the right PVs an... | 10.1002/joa3.12672 | 35,222,755 | Journal of arrhythmia | 2,022 | ||
Increased vigabatrin entry into the brain by polysorbate 80 and sodium caprate. | The effects of a non-ionic surfactant, polysorbate 80, and the sodium salt of the saturated fatty acid, sodium caprate (C10), as potential brain absorption enhancers for vigabatrin were studied. Vigabatrin is an enzyme-activated irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase that increases brain ... | 10.1211/0022357011775343 | 11,273,010 | D000818:Animals; D000927:Anticonvulsants; D001831:Body Temperature; D001921:Brain; D003652:Decanoic Acids; D004912:Erythrocytes; D005079:Excipients; D008297:Male; D011136:Polysorbates; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D020888:Vigabatrin; D005680:gamma-Aminobutyric... | The Journal of pharmacy and pharmacology | 2,001 | D000927:Anticonvulsants; D003652:Decanoic Acids; D005079:Excipients; D011136:Polysorbates; C031071:decanoic acid; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin |
Extended-release formulations of tramadol in the treatment of chronic pain. | INTRODUCTION
Tramadol is a centrally acting analgesic available throughout the world. Its dual opioid and non-opioid mechanisms of action, favorable efficacy and safety clinical profiles and non-controlled regulatory status in most markets contribute to its widespread use. A drawback of the immediate-release formulatio... | 10.1517/14656566.2011.576250 | 21,609,187 | D000701:Analgesics, Opioid; D000818:Animals; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D006801:Humans; D055118:Medication Adherence; D010146:Pain; D014147:Tramadol | Expert opinion on pharmacotherapy | 2,011 | D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D014147:Tramadol |
Purification and characterization of an acid phosphatase from the commercial mushroom Agaricus bisporus. | Acid phosphatase [AP; EC 3.1.3.2], a key enzyme involved in the synthesis of mannitol in Agaricus bisporus, was purified to homogeneity and characterized. The native enzyme appeared to be a high molecular weight type glycoprotein. It has a molecular weight of 145 kDa and consists of four identical 39-kDa subunits. The ... | 10.1023/a:1002450221778 | 15,188,886 | D000135:Acid Phosphatase; D000249:Adenosine Monophosphate; D000364:Agaricus; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004492:Edetic Acid; D004591:Electrophoresis, Polyacrylamide Gel; D004791:Enzyme Inhibitors; D005636:Fructosephosphates; D005656:Fungal Proteins... | Antonie van Leeuwenhoek | 2,000 | D004791:Enzyme Inhibitors; D005636:Fructosephosphates; D005656:Fungal Proteins; D005994:Glycerophosphates; D006023:Glycoproteins; D008355:Mannitol Phosphates; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D010710:Phosphates; D021122:Protein Subunits; D013644:Tartrates; C030070:mannitol-1-phosphate; C008644:... |
Genetic and molecular analysis of a new unbalanced X;18 rearrangement: localization of the diminished ovarian reserve disease locus in the distal Xq POF1 region. | BACKGROUND
Diminished ovarian reserve (DOR) is a heterogeneous disorder causing infertility, characterized by a decreased number of oocytes, the genetic cause of which is still unknown.
METHODS AND RESULTS
We describe a family with a new unbalanced X;18 translocation der(X) associated with either fully attenuated or ... | 10.1093/humrep/der266 | 21,859,812 | D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D041321:Chromosomes, Human, X; D005260:Female; D020868:Gene Silencing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle A... | Human reproduction (Oxford, England) | 2,011 | |
Improvement of the production of GFPuv-beta1,3-N-acetylglucosaminyltransferase 2 fusion protein using a molecular chaperone-assisted insect-cell-based expression system. | A stable Tn-5B1-4 insect cell line co-expressing the recombinant GFPuv-beta1,3-N-acetylglucosaminyltransferase 2 (GFPuv-beta3GnT2) protein fused to a melittin signal sequence with a lectin-like molecular chaperone, human calnexin (hCNX) or human calreticulin (hCRT), was constructed. The expression of either of these mo... | 10.1002/bit.20362 | 15,609,270 | D000818:Animals; D001709:Biotechnology; D012831:Bombyx; D037281:Calnexin; D037282:Calreticulin; D002460:Cell Line; D049452:Green Fluorescent Proteins; D006801:Humans; D018832:Molecular Chaperones; D017351:N-Acetylglucosaminyltransferases; D011401:Promoter Regions, Genetic; D011993:Recombinant Fusion Proteins | Biotechnology and bioengineering | 2,005 | D037282:Calreticulin; D018832:Molecular Chaperones; D011993:Recombinant Fusion Proteins; D037281:Calnexin; D049452:Green Fluorescent Proteins; D017351:N-Acetylglucosaminyltransferases; C428132:B3GNT2 protein, human |
Sigmoid colon perforation at CT colonography secondary to a possible obstructive mechanism: report of a case. | We report a case of colonic perforation in CT colonography, which was observed in a sigmoid colon segment contained within an inguinal hernia. At surgery, apart from the perforation, a normal large-bowel wall was found. Although rare, perforation may occur in patients with normal bowel wall, possibly resulting from a m... | 10.1007/s10350-007-0309-3 | 17,665,253 | D000368:Aged; D012809:Colon, Sigmoid; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006552:Hernia, Inguinal; D006801:Humans; D007415:Intestinal Obstruction; D007813:Laparotomy; D008297:Male; D012421:Rupture; D012810:Sigmoid Diseases | Diseases of the colon and rectum | 2,007 | |
Cycling to Meet Fate: Connecting Pluripotency to the Cell Cycle. | Pluripotent stem cells are characterized by their high proliferative rates, their ability to self-renew and their potential to differentiate to all the three germ layers. This rapid proliferation is brought about by a highly modified cell cycle that allows the cells to quickly shuttle from DNA synthesis to cell divisio... | 10.3389/fcell.2018.00057 | 29,974,052 | Frontiers in cell and developmental biology | 2,018 | ||
cis/trans-[Pt(C∧N)(C≡CR)(CNBu)] Isomers: Synthesis, Photophysical, DFT Studies, and Chemosensory Behavior. | cis/trans Isomerism can be a crucial factor for photophysical properties. Here, we report the synthesis and optical properties of a series of trans- and cis-alkynyl/isocyanide cycloplatinated compounds [Pt(C∧N)(C≡CR)(CNBu)] [R = C6H4-4-OMe 1, 3-C4H3S 2; C∧N = 2-(2,4-difluorophenyl)pyridine (dfppy) (a), 4-(2-pyridyl)ben... | 10.1021/acs.inorgchem.3c01196 | 37,458,185 | Inorganic chemistry | 2,023 | ||
Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1). | Flap endonuclease-1 (FEN-1) is a structure-specific endonuclease that is critical for the resolution of single-stranded DNA flap intermediates that form during long patch DNA base excision repair (BER). This investigation reports that Plasmodium species encode FEN-1 homologs. Protein sequence analysis revealed the N an... | 10.1016/j.molbiopara.2007.08.008 | 17,928,073 | D000818:Animals; D001665:Binding Sites; D002413:Cations, Divalent; D003001:Cloning, Molecular; D004247:DNA; D004720:Endonucleases; D004791:Enzyme Inhibitors; D004926:Escherichia coli; D005092:Exonucleases; D045585:Flap Endonucleases; D015870:Gene Expression; D007700:Kinetics; D008274:Magnesium; D008345:Manganese; D0089... | Molecular and biochemical parasitology | 2,008 | D002413:Cations, Divalent; D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; D011994:Recombinant Proteins; D008345:Manganese; D004247:DNA; D004720:Endonucleases; D005092:Exonucleases; D045585:Flap Endonucleases; D008274:Magnesium |
Treacher Collins syndrome: A case report and review of ophthalmic features. | Treacher Collins syndrome is a congenital disorder with bilaterally symmetric anomalies of the structures developing from the first and second branchial arches. The ocular and orbital features are an obligatory component for the diagnosis. We presented a case of typical, complete syndrome and also reviewed the varied o... | 10.1016/j.tjo.2016.07.002 | 29,018,745 | Taiwan journal of ophthalmology | 2,016 | ||
[Port wine stains and Pulsed Dye Laser: study of prognostic factors in 74 Moroccan patients]. | Pulsed dye laser (LCP) is currently the gold standard for Port wine stains (PWS) treatment. However, predictive clinical criteria indicating a right or poor response are not yet clear in our context. This study aims to determine the factors associated with poor/good response in Moroccan patients with PWS treated with L... | 10.11604/pamj.2016.25.218.9229 | 28,292,171 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005145:Face; D005260:Female; D006801:Humans; D054025:Lasers, Dye; D008297:Male; D009018:Morocco; D017060:Patient Satisfaction; D019339:Port-Wine Stain; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin; D01689... | The Pan African medical journal | 2,016 | |
Physical evaluation of a maize-based extruded snack with curry powder. | Response surface methodology was used to analyze the effect of screw speed (200-280 rpm), feed moisture (13.0-17.0%, wet basis), and curry powder (6.0-9.0%) on the bulk density, lateral expansion, and firmness of maize-based extruded snack with curry powder. Regression equations describing the effect of each variable o... | 10.1002/food.200300388 | 15,053,354 | D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005511:Food Handling; D019649:Food Industry; D005524:Food Technology; D012212:Rheology; D017365:Spices; D003313:Zea mays | Die Nahrung | 2,004 | |
Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. | OBJECTIVE
A hallmark of chronic HBV (cHBV) infection is the presence of impaired HBV-specific CD8+ T cell responses. Functional T cell exhaustion induced by persistent antigen stimulation is considered a major mechanism underlying this impairment. However, due to their low frequencies in chronic infection, it is curren... | 10.1136/gutjnl-2018-316641 | 30,622,109 | D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes; D015331:Cohort Studies; D005260:Female; D015684:Gene Products, pol; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014758:Viral Core Proteins; D019562:Viral Load | Gut | 2,019 | D015684:Gene Products, pol; C066027:P protein, Hepatitis B virus; D014758:Viral Core Proteins |
Data quality. An illustration of its potential impact upon a diagnosis-related group's case mix index and reimbursement. | The Health Care Finance Administration has developed a Medicare reimbursement methodology that will include an adjustment factor for hospital case mix. The patient classification scheme proposed for use in determining a hospital's case mix is the AUTOGRP Diagnosis-Related Groups (DRG) methodology developed at Yale Univ... | 6,418,985 | D003365:Costs and Cost Analysis; D003953:Diagnosis-Related Groups; D006785:Hospitals, University; D008499:Medical Records; D006278:Medicare; D009820:Ohio; D012051:Reimbursement Mechanisms; D013514:Surgical Procedures, Operative; D014481:United States | Medical care | 1,983 | ||
Comparative genomics of streptococcal species. | Microbial genome sequencing has produced an unprecedented amount of new information and insights into an organism's metabolic activities, virulence properties, and evolution. The complete genome sequence has been reported for four different species of streptococci, including Streptococcus pyogenes, S. agalactiae, S. pn... | 15,232,152 | D016680:Genome, Bacterial; D013045:Species Specificity; D013291:Streptococcus | The Indian journal of medical research | 2,004 | ||
Electrogenerated chemiluminescence of Si quantum dots in neutral aqueous solution and its biosensing application. | Electrogenerated chemiluminescence (ECL) of semiconductor quantum dots (QDs) has been considered as a powerful technique in the fabrication of biosensor, however, high-toxicity of heavy metal ion containing in QDs severely limits their further applications, and the search for the alternative benign nanomaterials with h... | 10.1016/j.bios.2016.10.011 | 27,825,526 | D015374:Biosensing Techniques; D004247:DNA; D004735:Energy Transfer; D006046:Gold; D057230:Limit of Detection; D049449:Luminescence; D019216:Metals, Heavy; D053758:Nanoparticles; D045663:Quantum Dots; D012666:Semiconductors; D012825:Silicon | Biosensors & bioelectronics | 2,017 | D019216:Metals, Heavy; D006046:Gold; D004247:DNA; D012825:Silicon |
Decoding of intended saccade direction in an oculomotor brain-computer interface. | OBJECTIVE
To date, invasive brain-computer interface (BCI) research has largely focused on replacing lost limb functions using signals from the hand/arm areas of motor cortex. However, the oculomotor system may be better suited to BCI applications involving rapid serial selection from spatial targets, such as choosing ... | 10.1088/1741-2552/aa5a3e | 28,098,561 | D000818:Animals; D062207:Brain-Computer Interfaces; D004567:Electrodes, Implanted; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009802:Oculomotor Nerve; D010775:Photic Stimulation; D017397:Prefrontal Cortex; D011897:Random Allocation; D012438:Saccades | Journal of neural engineering | 2,017 | |
MicroRNA-149 suppresses the malignant phenotypes of ovarian cancer via downregulation of MSI2 and inhibition of PI3K/AKT pathway. | OBJECTIVE
Ovarian cancer (OC) is one of the most lethal gynecologic malignant tumors. Emerging evidence has indicated that the dysregulation of microRNAs (miRNAs/miRs) participates in the OC progression. It has been revealed that miR-149 acts either as an oncogene or a tumour suppressor in various human tumors. The cur... | 10.26355/eurrev_202001_19895 | 31,957,818 | D015536:Down-Regulation; D005260:Female; D006801:Humans; D035683:MicroRNAs; D008875:Middle Aged; D010051:Ovarian Neoplasms; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D016601:RNA-Binding Proteins | European review for medical and pharmacological sciences | 2,020 | C551557:MIRN149 microRNA, human; C438151:MSI2 protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; D051057:Proto-Oncogene Proteins c-akt |
Adult Pineal Region Atypical Teratoid Rhabdoid Tumor: A Case for Aggressive Surgical and Chemoradiation Management with Comprehensive Literature Review. | BACKGROUND
Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system neoplasm classified as an embryonal grade IV neoplasm by the World Health Organization. ATRT generally occurs in children younger than 3 years, with 85 pathologically confirmed cases reported in adults. It is most comm... | 10.1016/j.wneu.2020.06.144 | 32,599,188 | D000328:Adult; D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures; D018335:Rhabdoid Tumor; D013724:Teratoma | World neurosurgery | 2,020 | |
Progress of Materials and Devices for Neuromorphic Vision Sensors. | The latest developments in bio-inspired neuromorphic vision sensors can be summarized in 3 keywords: smaller, faster, and smarter. (1) Smaller: Devices are becoming more compact by integrating previously separated components such as sensors, memory, and processing units. As a prime example, the transition from traditio... | 10.1007/s40820-022-00945-y | 36,242,681 | Nano-micro letters | 2,022 | ||
Comprehensive Dental Treatment under General Anesthesia Improves Mastication Capability in Children with Early Childhood Caries-A One-Year Follow-Up Study. | BACKGROUND
Using the granulometry of ready-to-swallow food boluses, this study investigated the evolution of masticatory capability of children with Early Childhood Caries (ECC) after comprehensive dental treatment under general anesthesia (GA).
METHODS
Sixteen children with ECC were assessed before and over one year... | 10.3390/ijerph20010677 | 36,612,993 | D006801:Humans; D002675:Child, Preschool; D002648:Child; D008409:Mastication; D005500:Follow-Up Studies; D011788:Quality of Life; D003733:Dental Caries Susceptibility; D003731:Dental Caries; D002611:Cheese; D000768:Anesthesia, General; D003729:Dental Care | International journal of environmental research and public health | 2,022 | |
Rheology of blood by NMR. | Pipe flow of blood in tubes of 1 and 7 mm inner diameter, respectively, was investigated employing two-dimensional NMR velocity imaging and PFG propagator measurements at different Reynolds numbers between 10 and 3500. The results are compared to flow of a water/glycerol mixture of matching viscosity under identical co... | 10.1006/jmre.2001.2387 | 11,531,367 | D000818:Animals; D018056:Hemorheology; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D013552:Swine | Journal of magnetic resonance (San Diego, Calif. : 1997) | 2,001 | |
Paediatric rhabdoid meningioma: clinical and therapeutic features findings: case series of 3 patients. | INTRODUCTION
Pediatric Rhabdoid Meningioma (RM) are the rarest, but most aggressive subtypes of meningioma, related to a severe prognosis. They account for 1-3% of all intracranial meningiomas.
CASE PRESENTATIONS
We report an institutional experience of 3 cases through which we discuss clinical, histological and ther... | 10.1159/000535715 | 38,091,966 | Pediatric neurosurgery | 2,023 | ||
Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review of the literature. | Pleural effusion or ascites complicating plasmacytoma is rare and has a poor prognosis. A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained a very good partial response. After MP he was diagnose... | 10.2169/internalmedicine.51.7061 | 22,687,849 | D000368:Aged; D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols; D001201:Ascites; D001897:Boronic Acids; D000069286:Bortezomib; D017809:Fatal Outcome; D006801:Humans; D007952:Leukemia, Plasma Cell; D008297:Male; D008558:Melphalan; D016066:Pleural Effusion, Malignant; D011241:Predniso... | Internal medicine (Tokyo, Japan) | 2,012 | D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D008558:Melphalan; D011241:Prednisone |
The adolescent athlete: a musculoskeletal update. | Adolescent athletes are participating in new and popular sports. What are today's musculoskeletal concerns for these athletes? The purpose of this paper is to provide an update on what is currently known about the young athlete and how contributing factors of injury have changed accordingly. Preventative measures are i... | 10.2519/jospt.1983.5.1.20 | 18,806,438 | The Journal of orthopaedic and sports physical therapy | 1,983 | ||
The association of marital relationship and perceived social support with mental health of women in Pakistan. | BACKGROUND
Marital circumstances have been indicated to be a salient risk factor for disproportionately high prevalence of depression and anxiety among Pakistani women. Although social support is a known buffer of psychological distress, there is no clear evidence as to how different aspects of marital relations intera... | 10.1186/1471-2458-13-1150 | 25,226,599 | D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety; D003863:Depression; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008393:Marriage; D008875:Middle Aged; D010154:Pakistan; D010549:Personal Satisfaction; D011569:... | BMC public health | 2,013 | |
The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke. | Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. We investigated whether the monocyte to high-density lipoprotein ratio (MHR) is related to HT. Consecutive patients with ischemic stroke within 24 h of symptom onset were included in this study. HT was diagnosed by follow-u... | 10.18632/aging.102757 | 32,023,223 | D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D000083302:Hemorrhagic Stroke; D006801:Humans; D015994:Incidence; D000083242:Ischemic Stroke; D008075:Lipoproteins, HDL; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D012307:Risk Factors | Aging | 2,020 | D008075:Lipoproteins, HDL |
The effects of anticoagulant therapy re-initiation after gastrointestinal bleeding: A systematic review and meta-analysis. | WHAT IS KNOWN AND OBJECTIVE
Long-term anticoagulant/antithrombotic therapy is widely used for the management of thromboembolic conditions. Gastrointestinal bleeding is a common collateral manifestation of anticoagulant/antithrombotic therapy that complicates its administration. The continuation or discontinuation of an... | 10.1111/jcpt.13442 | 34,101,229 | D000925:Anticoagulants; D004334:Drug Administration Schedule; D005343:Fibrinolytic Agents; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D010975:Platelet Aggregation Inhibitors; D012307:Risk Factors; D013927:Thrombosis | Journal of clinical pharmacy and therapeutics | 2,021 | D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors |
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression. | Our previous studies revealed that pregnancy associated breast cancer (PABC) had significantly reduced nuclear p63 expression in myoepithelia, while intense cytoplasmic p63 expression in associated epithelia. Our current study assessed these epithelia using immunohistochemistry with a panel of aggressiveness and invasi... | 10.7150/ijbs.6.428 | 20,714,441 | D001943:Breast Neoplasms; D016000:Cluster Analysis; D003593:Cytoplasm; D056915:DNA Copy Number Variations; D004847:Epithelial Cells; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D011247:Pregnancy; D011252:Pregnancy Complicat... | International journal of biological sciences | 2,010 | C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins |
Time course of interferon levels, antiviral state, 2',5'-oligoadenylate synthetase and side effects in healthy men. | The kinetics of the biologic response following a single intramuscular injection of 18 X 10(6) units of recombinant human interferon-alpha 2a (rHuIFN-alpha 2a) was investigated during 11 courses in 10 healthy individuals. Serial peripheral blood mononuclear cell (PBM) samples were assayed for their biologic responsiven... | 10.1089/jir.1987.7.29 | 3,035,034 | D015088:2',5'-Oligoadenylate Synthetase; D000328:Adult; D000998:Antiviral Agents; D004790:Enzyme Induction; D005334:Fever; D006801:Humans; D007370:Interferon Type I; D007700:Kinetics; D007962:Leukocytes; D008231:Lymphopenia; D008297:Male; D014721:Vesicular stomatitis Indiana virus | Journal of interferon research | 1,987 | D000998:Antiviral Agents; D007370:Interferon Type I; D015088:2',5'-Oligoadenylate Synthetase |
Conscientious refusal and health professionals: does religion make a difference? | Freedom of Conscience and Freedom of Religion should be taken to protect two distinct sets of moral considerations. The former protects the ability of the agent to reflect critically upon the moral and political issues that arise in her society generally, and in her professional life more specifically. The latter prote... | 10.1111/bioe.12059 | 24,117,664 | D026688:Bioethical Issues; D003242:Conscience; D034462:Dissent and Disputes; D026690:Ethics, Clinical; D006282:Health Personnel; D006806:Human Rights; D006801:Humans; D016079:Refusal to Treat; D012068:Religion and Medicine | Bioethics | 2,014 | |
Nitric oxide release from polydimethylsiloxane-based polyurethanes. | Localized nitric oxide (NO) release from polymeric materials holds much promise for the prevention of coagulation often associated with implantable and extracorporeal blood-contacting devices. Films of polyurethane (PU) containing incorporated polyethyleneimine were thus exposed to NO gas to form diazeniumdiolates (NON... | 10.5301/jabfm.5000192 | 24,744,231 | D065966:Absorption, Physicochemical; D001672:Biocompatible Materials; D003198:Computer Simulation; D004058:Diffusion; D004129:Dimethylpolysiloxanes; D004343:Drug Implants; D007700:Kinetics; D008422:Materials Testing; D008956:Models, Chemical; D009569:Nitric Oxide; D020030:Nitric Oxide Donors; D011140:Polyurethanes | Journal of applied biomaterials & functional materials | 2,014 | D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D004343:Drug Implants; D020030:Nitric Oxide Donors; D011140:Polyurethanes; D009569:Nitric Oxide; C013830:baysilon |
Communication skills for mobile remote presence technology in clinical interactions. | The use of mobile robotic units for teleconsultation means that the clinician's cognitive and attention skills are divided between tele-operation of the robotic unit and the consultation with the patient. We developed a communication guide based on evidence-based patient-centred interviewing and telephone conferencing ... | 10.1258/135763307780096168 | 17,359,575 | D000293:Adolescent; D000328:Adult; D000368:Aged; D003142:Communication; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010817:Physician-Patient Relations; D019114:Remote Consultation | Journal of telemedicine and telecare | 2,007 | |
Messenger RNA for an antigen-specific binding molecule from an antigen-specific T-cell hybrid. | The T-cell hybridoma 51H7D specifically binds the hapten azobenzenearsonate (ABA). An antiserum (anti-PCIF) specific for antigenic determinants shared by antigen-binding molecules of T cells (TABM) was used to precipitate polyribosomes containing mRNA for TABM from this T-cell hybridoma. The resultant mRNA was translat... | 10.1073/pnas.81.5.1524 | 6,200,878 | D000818:Animals; D004247:DNA; D000939:Epitopes; D006825:Hybridomas; D051379:Mice; D008970:Molecular Weight; D010944:Plants; D011132:Polyribosomes; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D013601:T-Lymphocytes; D014908:Triticum; D010132:p-Azobenzenearsonate | Proceedings of the National Academy of Sciences of the United States of America | 1,984 | D000939:Epitopes; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D010132:p-Azobenzenearsonate; D004247:DNA |
Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. | Hypoxia results in differential expression of specific genes in certain cell types. In endothelial cells, hypoxia activates several genes that are known to be inducible by transcription factor AP-1, including endothelin-1 and platelet-derived growth factor-B (PDGF-B). In this study we demonstrated that other AP-1-induc... | 10.1016/0167-4781(95)00116-x | 7,578,260 | D001665:Binding Sites; D015687:Cell Hypoxia; D002478:Cells, Cultured; D017364:Collagenases; D016232:Endothelins; D004727:Endothelium; D005786:Gene Expression Regulation; D016758:Genes, jun; D006367:HeLa Cells; D006801:Humans; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D018808:Transcription Factor A... | Biochimica et biophysica acta | 1,995 | D016232:Endothelins; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D018808:Transcription Factor AP-1; D017364:Collagenases |
Eribulin targets a ch-TOG-dependent directed migration of cancer cells. | Non-cytotoxic concentrations of microtubule targeting agents (MTAs) interfere with the dynamics of interphase microtubules and affect cell migration, which could impair tumor angiogenesis and metastasis. The underlying mechanisms however are still ill-defined. We previously established that directed cell migration is d... | 10.18632/oncotarget.6147 | 26,497,677 | D000970:Antineoplastic Agents; D001665:Binding Sites; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D002633:Chemotaxis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005663:Furans; D006801:Humans; D007659:Ketones; D008869:Microtubule-Associated Proteins; D008870:Microtubules; D009361:Neoplasm Invasiv... | Oncotarget | 2,015 | D000970:Antineoplastic Agents; C454180:CKAP5 protein, human; D005663:Furans; D007659:Ketones; D008869:Microtubule-Associated Proteins; D014404:Tubulin; D050257:Tubulin Modulators; C490954:eribulin |
CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice. | Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive optic nerve degeneration and retinal ganglion cell loss. Axonal transport deficits have been demonstrated to be the earliest crucial pathophysiological changes underlying axonal degeneration in glaucoma. Here, we explore... | 10.1038/s41419-021-04445-6 | 34,897,284 | D000818:Animals; D001370:Axonal Transport; D001369:Axons; D004195:Disease Models, Animal; D005901:Glaucoma; D007429:Intraocular Pressure; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D012165:Retinal Ganglion Cells | Cell death & disease | 2,021 | D000076222:Mechanistic Target of Rapamycin Complex 1 |
Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. | Insulin-like growth factor I (IGF-I) plays a critical role in the induction of cell cycle progression and survival in many cell types. However, there is minimal IGF-I binding to hepatocytes, and a role for IGF-I in hepatocyte signaling has not been elucidated. The dynamics of IGF-I receptor (IGF-IR) activation were exa... | 10.1053/jhep.2002.37138 | 12,447,877 | D000818:Animals; D002478:Cells, Cultured; D004815:Epidermal Growth Factor; D022781:Hepatocytes; D018972:Insulin-Like Growth Factor Binding Protein 3; D010766:Phosphorylation; D051381:Rats; D017526:Receptor, IGF Type 1; D015398:Signal Transduction; D014443:Tyrosine; D019061:src-Family Kinases | Hepatology (Baltimore, Md.) | 2,002 | D018972:Insulin-Like Growth Factor Binding Protein 3; D014443:Tyrosine; D004815:Epidermal Growth Factor; D017526:Receptor, IGF Type 1; D019061:src-Family Kinases |
Investigations into the reduction of powder adhesion to stainless steel surfaces by surface modification to aid capsule filling. | The adhesion force of powder particles to stainless steel surfaces, which had been modified by various metal coatings, has been measured using a centrifuge technique. The surfaces were characterised by surface roughness and surface free energy measurements, whereas the particles, which had a particle size of 32-45 micr... | 10.1016/s0378-5173(98)00363-9 | 10,205,629 | D002214:Capsules; D002498:Centrifugation; D004349:Drug Packaging; D007785:Lactose; D011208:Powders; D013193:Stainless Steel; D013213:Starch | International journal of pharmaceutics | 1,999 | D002214:Capsules; D011208:Powders; D013193:Stainless Steel; D013213:Starch; D007785:Lactose |
Variation of candidate genes in triglyceride metabolism. | After more than a decade of study, investigators are grappling for a consensus regarding the relationship between variation in candidate genes and plasma triglyceride concentration. Certain variants of LPL--both rare variants, in the case of loss-of-function mutations in kindreds with chylomicronemia, and common varian... | 10.1177/204748730000700503 | 11,143,760 | D003327:Coronary Disease; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D008071:Lipoprotein Lipase; D012680:Sensitivity and Specificity; D014280:Triglycerides | Journal of cardiovascular risk | 2,000 | D014280:Triglycerides; D008071:Lipoprotein Lipase |
60-W average power in 810-fs pulses from a thin-disk Yb:YAG laser. | We demonstrate a passively mode-locked diode-pumped thin-disk Yb:YAG laser generating 810-fs pulses at 1030 nm with as much as 60 W of average output power (without using an amplifier). At a pulse repetition rate of 34.3 MHz, the pulse energy is 1.75 microJ and the peak power is as high as 1.9 MW. The beam quality is c... | 10.1364/ol.28.000367 | 12,659,446 | Optics letters | 2,003 | ||
Use of opioids and other analgesics by older adults in the United States, 1999-2010. | BACKGROUND AND OBJECTIVE
There has been concern over rising use of prescription opioids in young and middle-aged adults. Much less is known about opioid prescribing in older adults, for whom clinical recommendations and the balance of risks and benefits differ from younger adults. We evaluated changes in use of opioids... | 10.1111/pme.12613 | 25,352,175 | D000368:Aged; D000700:Analgesics; D000701:Analgesics, Opioid; D003430:Cross-Sectional Studies; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010818:Practice Patterns, Physicians'; D014481:United States | Pain medicine (Malden, Mass.) | 2,015 | D000700:Analgesics; D000701:Analgesics, Opioid |
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