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Screening and counseling associated with obesity diagnosis in a national survey of ambulatory pediatric visits. | OBJECTIVE
To examine clinician-reported diagnosis of obesity and frequency of blood pressure assessment and diet and exercise counseling during ambulatory visits made by children and adolescents.
METHODS
The National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey 1997 to 2000 were... | 10.1542/peds.2004-1517 | 15,995,040 | D000293:Adolescent; D001795:Blood Pressure Determination; D002648:Child; D002675:Child, Preschool; D003376:Counseling; D019538:Health Care Surveys; D006801:Humans; D009765:Obesity; D050177:Overweight; D010372:Pediatrics; D015431:Weight Loss | Pediatrics | 2,005 | |
Fluoxetine, a selective serotonin-uptake inhibitor, enhances the anticonvulsant effects of phenytoin, carbamazepine, and ameltolide (LY201116). | Dose-response curves for the prototypical anticonvulsants phenytoin (PHT) and carbamazepine (CBZ), and a novel anticonvulsant, ameltolide (LY201116), were determined with and without pretreatment with the selective serotonin-uptake inhibitor fluoxetine by maximal electroshock seizure (MES) test in mice. Fluoxetine (2.5... | 10.1111/j.1528-1157.1992.tb01712.x | 1,534,297 | D000818:Animals; D001549:Benzamides; D002220:Carbamazepine; D003866:Depressive Disorder; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004827:Epilepsy; D005473:Fluoxetine; D008297:Male; D051379:Mice; D014179:Neurotransmitter Uptake Inhibitors; D010672:Phenytoin; D... | Epilepsia | 1,992 | D001549:Benzamides; D014179:Neurotransmitter Uptake Inhibitors; D005473:Fluoxetine; D012701:Serotonin; D002220:Carbamazepine; D010672:Phenytoin; C055323:ameltolide |
Genetic interaction between Ptc2 and protein phosphatase 4 (PP4) in the regulation of DNA damage response and virulence in Candida albicans. | In the pathogenic fungus Candida albicans, phosphoregulation of the checkpoint kinase Rad53 plays a crucial role in the filamentous growth response to genotoxic stresses. The protein phosphatase 4 (PP4) complex, containing Pph3 and either Psy2 or Psy4, is proved to play a critical role in Rad53 dephosphorylation. In pr... | 10.1093/femsyr/foz075 | 31,644,792 | D000818:Animals; D002176:Candida albicans; D004249:DNA Damage; D004271:DNA, Fungal; D005656:Fungal Proteins; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010749:Phosphoprotein Phosphatases; D010766:Phosphorylation; D000071636:Protein Phosph... | FEMS yeast research | 2,019 | D004271:DNA, Fungal; D005656:Fungal Proteins; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C; C080406:protein phosphatase 4 |
Associations of maternal metabolic profile with placental and fetal cerebral and cardiac hemodynamics. | OBJECTIVE
Maternal obesity and metabolic health affect pregnancy outcomes. We examined whether maternal metabolic profiles are associated with placental and fetal hemodynamics.
STUDY DESIGN
In a population-based prospective cohort study among 1175 women we examined the associations of an adverse maternal metabolic pr... | 10.1016/j.ejogrb.2020.12.011 | 33,360,239 | D005260:Female; D005333:Fetus; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D055442:Metabolome; D020768:Middle Cerebral Artery; D010920:Placenta; D011247:Pregnancy; D011446:Prospective Studies | European journal of obstetrics, gynecology, and reproductive biology | 2,021 | |
Binding characteristics of antibodies to the TSH receptor. | We have used fragments of the TSH receptor (TSHR) expressed in E. coli as glutathione S-transferase fusion proteins to produce rabbit polyclonal antibodies and a panel (n=5) of monoclonal antibodies to the extracellular fragment of the TSHR. The binding characteristics of the antibodies to linear, conformational, glyco... | 10.1677/jme.0.0200233 | 9,584,838 | D000818:Animals; D000911:Antibodies, Monoclonal; D001666:Binding Sites, Antibody; D015153:Blotting, Western; D016466:CHO Cells; D002469:Cell Separation; D006224:Cricetinae; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D011817:Rabbits; D011989:Receptors, Thyrotropin; D011... | Journal of molecular endocrinology | 1,998 | D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D011989:Receptors, Thyrotropin; D011994:Recombinant Proteins; D013972:Thyrotropin |
Expression of tissue non-specific alkaline phosphatase stimulates differentiated behaviour in specific transformed cell populations. | BACKGROUND
Tissue non-specific alkaline phosphatase (TN-AP) is a membrane-bound glycoprotein enzyme which is characterized by its phosphohydrolytic activity. This enzyme is distributed virtually in all mammalian tissues during embryonic development (it can be demonstrated as early as the 2-cell stage) where its express... | 10.1002/(SICI)1097-0185(199604)244:4<423::AID-AR1>3.0.CO;2-W | 8,694,278 | D000469:Alkaline Phosphatase; D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D016466:CHO Cells; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002461:Cell Line, Transformed; D002465:Cell Movement; D006224:Cricetinae; D005347:Fibroblasts; D018014:Gene Transfer Techniq... | The Anatomical record | 1,996 | D012333:RNA, Messenger; D014404:Tubulin; D000469:Alkaline Phosphatase |
Mass fragmentographic identification of polyamine metabolites in the urine of normal persons and cancer patients, and its relevance to the use of polyamines as tumour markers. | The mass fragmentographic identification of N-(2-carboxyethyl)-4-amino-n-butyric acid, N-(3-aminopropyl)-N1-(2-carboxyethyl)-1,4-diaminobutane, N,N1-bis(2-carboxyethyl)-1,4-diaminobutane, and delta-aminovaleric acid in acid-hydrolysed urines of a normal person and two cancer patients is described. A previous study, in ... | 10.1016/s0378-4347(00)84649-6 | 4,008,565 | D000596:Amino Acids; D000818:Animals; D000970:Antineoplastic Agents; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008223:Lymphoma; D009369:Neoplasms; D011073:Polyamines; D051381:Rats; D013997:Time Factors | Journal of chromatography | 1,985 | D000596:Amino Acids; D000970:Antineoplastic Agents; D011073:Polyamines |
Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components. | Oxidative stress is frequently mentioned in relation to the neurodegenerative diseases. This study examined the effect of three herb extracts, Hypericum perforatum, Ginkgo biloba L. and Apocynum venetum L., and their components on lipid hydroperoxide-induced oxidative stress in PC-12 cells. Among them, the extract of A... | 10.2152/jmi.52.249 | 16,366,510 | D000818:Animals; D000928:Antidepressive Agents; D000975:Antioxidants; D030010:Apocynum; D002454:Cell Differentiation; D004305:Dose-Response Relationship, Drug; D005502:Food; D020441:Ginkgo biloba; D020902:Hypericum; D008041:Linoleic Acids; D015227:Lipid Peroxidation; D008054:Lipid Peroxides; D020932:Nerve Growth Factor... | The journal of medical investigation : JMI | 2,005 | D000928:Antidepressive Agents; D000975:Antioxidants; D008041:Linoleic Acids; D008054:Lipid Peroxides; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C038649:13-hydroperoxy-9,11-octadecadienoic acid; C021304:hyperoside; D020932:Nerve Growth Factor; D011794:Quercetin |
[Is the lung a target organ in inflammatory bowel disease?]. | Inflammatory bowel disease is a systemic illness that may involve the lung. The most common manifestation of pulmonary involvement is an asymptomatic reduction in lung transfer factor for carbon monoxide (Dlco) and a small airway disorders easy to find in subjects with active disease. Some patients show a bronchial inf... | 11,822,102 | D000305:Adrenal Cortex Hormones; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D001982:Bronchial Diseases; D001987:Bronchiectasis; D002648:Child; D003093:Colitis, Ulcerative; D003424:Crohn Disease; D005765:Gastrointestinal Agents; D006801:Humans; D015212:Inflammatory Bowel Diseases; D... | Recenti progressi in medicina | 2,001 | D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D012460:Sulfasalazine; D001241:Aspirin | |
[Comparative analysis of in vitro test procedures for evaluating hemocompatibility of cardiovascular stents]. | Within the scope of this study existing in vitro techniques for testing the hemocompatibility of coronary stents were analysed and optimised. Static and quasi-stationary systems were compared to a pulsed flow model with respect to platelet activity. The streamlines were visualized by dye injection. Blood flow was measu... | 10.1515/bmte.2002.47.s1b.827 | 12,465,315 | D015906:Angioplasty, Balloon, Coronary; D001696:Biomechanical Phenomena; D001769:Blood; D001783:Blood Flow Velocity; D015926:Complement C3a; D023921:Coronary Stenosis; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008955:Models, Cardiovascular; D013193:Stainless Steel; D015607:Stents; D001620... | Biomedizinische Technik. Biomedical engineering | 2,002 | D001620:beta-Thromboglobulin; D013193:Stainless Steel; D015926:Complement C3a |
Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom. | The present study investigates the electrophysiological actions of BmK M1, an alpha-like toxin purified from the venom of the scorpion Buthus martensi Karsch, on voltage-gated Na+ channels. Using the voltage clamp technique, we assessed the BmK M1 activity on the cardiac Na+ channel (hH1) functionally expressed in Xeno... | 10.1016/s0014-5793(01)02365-1 | 11,322,948 | D000818:Animals; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression; D006801:Humans; D019476:Insect Proteins; D008564:Membrane Potentials; D008845:Microinjections; D008969:Molecular Sequence Data; D009498:Neurotoxins; D009865:Oocytes; D018408:Patch-Clamp Techniques; D018075:RNA, Complementary; D012604:Sc... | FEBS letters | 2,001 | C403888:BmK M1 neurotoxin; D019476:Insect Proteins; D009498:Neurotoxins; D018075:RNA, Complementary; D012604:Scorpion Venoms; D026941:Sodium Channel Blockers; D015222:Sodium Channels |
Fundamental study on subharmonic imaging by irradiation of amplitude-modulated ultrasound waves. | The second harmonic and subharmonic components, the frequencies of which are twice and one half the fundamental frequency, are included in echoes from contrast agents. An imaging method, which employs a second harmonic (second harmonic imaging), is widely used in medical diagnoses. On the other hand, subharmonic is exp... | 10.1121/1.2743160 | 17,614,523 | D000362:Agar; D003287:Contrast Media; D045423:Microbubbles; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D013018:Sound Spectrography; D014463:Ultrasonography | The Journal of the Acoustical Society of America | 2,007 | D003287:Contrast Media; D000362:Agar |
MATEO: a software package for the molecular design of energetic materials. | To satisfy the need of energetic materials chemists for reliable and efficient predictive tools in order to select the most promising candidates for synthesis, a custom software package is developed. Making extensive use of publicly available software, it integrates a wide range of models and can be used for a variety ... | 10.1016/j.jhazmat.2009.11.030 | 19,962,822 | D003196:Computer Graphics; D003198:Computer Simulation; D008958:Models, Molecular; D012984:Software; D014584:User-Computer Interface | Journal of hazardous materials | 2,010 | |
Recent progress of probing correlated electron states by point contact spectroscopy. | We review recent progress in point contact spectroscopy (PCS) to extract spectroscopic information out of correlated electron materials, with the emphasis on non-superconducting states. PCS has been used to detect bosonic excitations in normal metals, where signatures (e.g. phonons) are usually less than 1% of the meas... | 10.1088/0034-4885/79/9/094502 | 27,533,341 | Reports on progress in physics. Physical Society (Great Britain) | 2,016 | ||
The Sernbo score predicts 1-year mortality after displaced femoral neck fractures treated with a hip arthroplasty. | Background and purpose - Displaced femoral neck fractures (FNFs) are associated with high rates of mortality during the first postoperative year. The Sernbo score (based on age, habitat, mobility, and mental state) can be used to stratify patients into groups with different 1-year mortality. We assessed this predictive... | 10.1080/17453674.2017.1318628 | 28,426,259 | D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005265:Femoral Neck Fractures; D062785:Hemiarthroplasty; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D011446:Prospective St... | Acta orthopaedica | 2,017 | |
COVID-19, travel restrictions and environmental consequences. | The component of human life that has been most significantly altered by the COVID-19 epidemic is travel. Due to the upheaval produced by the pandemic breakout, countries are becoming increasingly avaricious and are scrambling to stockpile vaccines. The world has been locked down to reduce/control the pandemic outbreak,... | 10.1007/s10668-023-03146-8 | 37,363,034 | Environment, development and sustainability | 2,023 | ||
Pharmacokinetics of leucovorin (D,L-5-formyltetrahydrofolate) after intravenous injection and constant intravenous infusion. | The pharmacokinetics of the active and inactive diastereoisomers of leucovorin and its active metabolite, 5-methyltetrahydrofolate (5-CH3-THF) were studied after iv injection of leucovorin in normal human subjects at a dose of 28 mg/m2, and in patients given 500 mg/m2 daily by constant iv infusion for a 5.5 day period.... | 3,501,545 | D001711:Biotransformation; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D002955:Leucovorin; D013237:Stereoisomerism; D013763:Tetrahydrofolates | NCI monographs : a publication of the National Cancer Institute | 1,987 | D013763:Tetrahydrofolates; D002955:Leucovorin; C005984:5-methyltetrahydrofolate | |
Comparison of the effect of MTAD and conventional irrigation agents on apical leakage and push-out bond strength of root canal filling. | The aim of this study was to evaluate the effect of MTAD (a mixture of tetracycline isomer, an acid, and a detergent) and conventional irrigation agents on the apical leakage and push-out bond strength of root canal filling and to correlate the apical leakage and push-out bond strength. Root canals of 120 maxillary cen... | 10.1002/sca.21208 | 26,477,884 | D001840:Dental Bonding; D003763:Dental Leakage; D006801:Humans; D007180:Incisor; D055595:Mechanical Phenomena; D012388:Root Canal Irrigants; D018915:Root Canal Preparation | Scanning | 2,015 | D012388:Root Canal Irrigants |
Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. | Mesenchymal stem cells (MSCs) are increasingly being reported as occurring in a variety of tissues. Although MSCs from human bone marrow are relatively easy to harvest, the isolation of rodent MSCs is more difficult, thereby limiting the number of experiments in vivo. To determine a suitable cell source, we isolated ra... | 10.1007/s00441-006-0308-z | 17,053,900 | D000273:Adipose Tissue; D000818:Animals; D015415:Biomarkers; D001854:Bone Marrow Cells; D002452:Cell Count; D002454:Cell Differentiation; D049109:Cell Proliferation; D020219:Chondrogenesis; D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D008297:Male; D059630:Mesenchymal Stem Cells; D018485:Muscle Fibers, Skeletal... | Cell and tissue research | 2,007 | D015415:Biomarkers; D006025:Glycosaminoglycans; D006820:Hyaluronic Acid |
Outcomes research: an essential component of the advanced practice nurse role. | More research is needed that focuses on the effectiveness of nursing interventions in clinical settings. Advanced practice nurses are in the best position to conduct these studies, given their clinical expertise, access to subjects, master's-level research education, and need to demonstrate the effectiveness of their o... | 10.1097/00002800-200205000-00007 | 12,021,613 | D006801:Humans; D009720:Nurse Clinicians; D015403:Nursing Evaluation Research; D017063:Outcome Assessment, Health Care; D014481:United States | Clinical nurse specialist CNS | 2,002 | |
The use of cocaine as an anesthetic in lacrimal surgery. | We investigated if the results of routine urine drug screening for cocaine metabolites would be positive after dacryocystorhinostomy. Postoperative urine specimens were analyzed for the presence of benzoylecgonine, the major metabolite of cocaine, using the Syva Emit assay with an inhouse cutoff of 50 ng/mL. Confirmati... | 10.1093/jat/18.1.54 | 8,127,087 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D003042:Cocaine; D003608:Dacryocystorhinostomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015813:Substance Abuse Detection | Journal of analytical toxicology | 1,994 | C005618:benzoylecgonine; D003042:Cocaine |
What is molt-inhibiting hormone? The role of an ecdysteroidogenesis inhibitor in the crustacean molting cycle. | The in vivo molt-inhibitory effects of the ecdysone biosynthesis inhibitors 3-hydroxy-L-kynurenine and xanthurenic acid were investigated. These ecdysone biosynthesis inhibitors, isolated from the eyestalks of blue crabs (Callinectes sapidus), were injected into eyestalk-ablated crayfish (Procambarus clarkii). The acti... | 10.1073/pnas.86.17.6826 | 16,594,067 | Proceedings of the National Academy of Sciences of the United States of America | 1,989 | ||
Nonmonotoic fluctuation-induced interactions between dielectric slabs carrying charge disorder. | We investigate the effect of monopolar charge disorder on the classical fluctuation-induced interactions between randomly charged net-neutral dielectric slabs and discuss various generalizations of recent results [A. Naji et al., Phys. Rev. Lett. 104, 060601 (2010)] to highly inhomogeneous dielectric systems with and w... | 10.1063/1.3497039 | 21,054,060 | D001704:Biopolymers; D003102:Colloids; D017097:Electric Impedance; D008956:Models, Chemical; D055672:Static Electricity; D013499:Surface Properties; D013816:Thermodynamics | The Journal of chemical physics | 2,010 | D001704:Biopolymers; D003102:Colloids |
Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands. | A series of 99mTc complexes containing a hydrazinonicotinamide-conjugated cyclic IIb/IIIa receptor antagonist, cyclo(D-Val-NMeArg-Gly-Asp-Mamb-(hydrazinonicotinyl-5- (6-aminocaproic acid))), were synthesized in high yield using tricine or other aminocarboxylates as coligands. These 99mTc complexes have the potential to... | 10.1021/bc950069+ | 8,741,992 | D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007202:Indicators and Reagents; D007700:Kinetics; D008024:Ligands; D008969:Molecular Sequence Data; D009536:Niacinamide; D015609:Organotechnetium Compounds; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011869:Radio... | Bioconjugate chemistry | 1,996 | D007202:Indicators and Reagents; D008024:Ligands; D015609:Organotechnetium Compounds; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D009536:Niacinamide; D013667:Technetium |
Effects of N, P, K and S on metabolism: new knowledge gained from multi-level analysis. | Deficiency of mineral nutrients such as nitrate, phosphate, potassium and sulphate strongly affects the type and amount of metabolites produced by crops with knock-on effects on nutritional quality of the crop, its processing properties and disease resistance. Owing to the multitude of biochemical reactions underlying ... | 10.1016/j.pbi.2009.04.014 | 19,493,694 | D009584:Nitrogen; D010758:Phosphorus; D010944:Plants; D011188:Potassium; D013455:Sulfur | Current opinion in plant biology | 2,009 | D010758:Phosphorus; D013455:Sulfur; D009584:Nitrogen; D011188:Potassium |
Spatial analysis of neural tube defects in a rural coal mining area. | Shanxi province in northern China has one of the highest reported prevalence rates of neural tube defects (NTDs) in the world. The current study selected Heshun, the county with the highest rate of NTDs in Shanxi, as a study area and tested whether residence in a coal mining area was a contributing factor. A NTD cluste... | 10.1080/09603123.2010.491854 | 21,161,805 | D000328:Adult; D002681:China; D003032:Coal Mining; D005260:Female; D040362:Geographic Information Systems; D006801:Humans; D050498:Live Birth; D016015:Logistic Models; D008297:Male; D009436:Neural Tube Defects; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D012424:Rural Population; D012959:Soc... | International journal of environmental health research | 2,010 | |
Relationship between immunoglobulin levels and extremes of solar activity. | The possible relationship between epidemics and extremes of solar activity has been discussed previously. The purpose of the present study was to verify whether differences in the levels of immunoglobulins (IgA, IgG, IgM) could be noted at the highest (July 1989) and lowest (September 1986) points of the last (21st) an... | 10.1007/BF01270665 | 7,698,858 | D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D008297:Male; D008685:Meteorological Concepts; D012727:Sex Characteristics; D016082:Solar System | International journal of biometeorology | 1,995 | D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins |
Recipient atrial flutter masquerading as donor flutter in a heart transplant recipient. | Atrial flutter is common after orthotopic heart transplantation. We present the case of a patient who presented with atrial flutter on 12-lead electrocardiogram. On invasive electrophysiologic study, the donor heart was found to be in sinus rhythm and the recipient atrium was in flutter, which was dissociated from the ... | 10.1016/j.healun.2007.01.015 | 17,403,487 | D001282:Atrial Flutter; D003937:Diagnosis, Differential; D004562:Electrocardiography; D004568:Electrodiagnosis; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia; D011183:Postoperative Complications; D014019:Tissue Donors | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation | 2,007 | |
Gingival evaluation of the pediatric cardiac patient. | PURPOSE
Children with congenital cardiovascular diseases (CCDs) who suffer from dental diseases have an increased risk of infective endocarditis. In the light of recent evidence, oral inflammatory diseases may also increase the severity of their cardiovascular condition. The purpose of this study was to evaluate the gi... | 24,290,561 | D000293:Adolescent; D000704:Analysis of Variance; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D002648:Child; D017742:Dental Care for Chronically Ill; D003773:Dental Plaque; D005260:Female; D005881:Gingiva; D006801:Humans; D008297:Male; D009909:Oral Health; D010510:Periodontal Diseases; D015995:Preval... | Pediatric dentistry | 2,013 | ||
Topography of striate-extrastriate connections in neonatally enucleated rats. | It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas. In nearly all lateral ex... | 10.1155/2013/592426 | 24,199,194 | D000818:Animals; D003342:Corpus Striatum; D015353:Eye Enucleation; D051381:Rats; D014794:Visual Fields | BioMed research international | 2,013 | |
[Human brucellosis: epidemiological situation in Chile, 2001-2010]. | BACKGROUND
Brucellosis is a zoonosis whose economical impact in endemic countries is significant. Its magnitude for humans has been scarcely measured in Chile, therefore brucellosis was declared a reportable disease since 2004.
OBJECTIVE
To characterize the epidemiology of human brucellosis in Chile.
MATERIAL
Data ... | 24,522,310 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002006:Brucellosis; D002648:Child; D002675:Child, Preschool; D002677:Chile; D018563:Disease Notification; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D055815:Young Adult | Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia | 2,013 | ||
Effects of hormones, amino acids and specific inhibitors on rat heart heparin-releasable lipoprotein lipase and tissue neutral lipase activities during long-term perfusion. | Rat hearts were perfused for long periods in the presence of 14C-labeled amino acids. From these hearts, postheparin-effluent and a tissue homogenate containing lipoprotein lipase and neutral lipase, respectively, were derived. Lipolytic activity and 14C-labeled protein in both preparations were characterized by affini... | 10.1016/0005-2760(84)90299-6 | 6,375,731 | D000596:Amino Acids; D000818:Animals; D003078:Colchicine; D003513:Cycloheximide; D003600:Cytosol; D005934:Glucagon; D006493:Heparin; D006728:Hormones; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera; D007328:Insulin; D007700:Kinetics; D008049:Lipase; D008071:Lipoprotein Lipase; D008297:Male; D009206:Myocardium;... | Biochimica et biophysica acta | 1,984 | D000596:Amino Acids; D006728:Hormones; D007106:Immune Sera; D007328:Insulin; D014415:Tunicamycin; D006493:Heparin; D005934:Glucagon; D003513:Cycloheximide; D011433:Propranolol; D008049:Lipase; D008071:Lipoprotein Lipase; D003078:Colchicine; D009638:Norepinephrine |
From wires to veins: wet-process fabrication of light-weight reticulation photoanodes for dye-sensitized solar cells. | Different shapes of photoanodes, including wires, nets, and veins, were assembled via an all-wet process on various light-weight and low-cost Ni-plated substrates without any transparent conducting oxides to fabricate flexible dye-sensitized solar cells (DSSCs) with a wide range of shapes and substrate materials. | 10.1039/c3cc49692a | 24,556,784 | Chemical communications (Cambridge, England) | 2,014 | ||
Graves' disease presenting with severe cholestasis. | BACKGROUND
Hyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported.
PATIENT SUMMARY
The patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' diseas... | 10.1089/thy.2011.0267 | 22,458,973 | D000293:Adolescent; D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D001663:Bilirubin; D002779:Cholestasis; D005260:Female; D006111:Graves Disease; D006506:Hepatitis A; D035922:Hepatitis A Antibodies; D006801:Humans; D007075:Immunoglobulin M; D008111:Liver Function Tests; D008713:Methimazole; D011433:P... | Thyroid : official journal of the American Thyroid Association | 2,012 | D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D035922:Hepatitis A Antibodies; D007075:Immunoglobulin M; D008713:Methimazole; D011433:Propranolol; D001663:Bilirubin |
In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium. | Chicken egg yolk antibody (IgY) raised against Salmonella enteritidis or Salmonella typhimurium was found in highly specific activity levels by ELISA. S. enteritidis- and S. typhimurium-specific IgY powder, prepared by freeze-drying the egg yolk water-soluble fraction, contained 15.5 and 10.0% of specific IgY, respecti... | 10.1093/ps/81.5.632 | 12,033,412 | D000818:Animals; D000907:Antibodies, Bacterial; D000918:Antibody Specificity; D002645:Chickens; D015169:Colony Count, Microbial; D003429:Cross Reactions; D004530:Egg Yolk; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D007136:Immunoglobulins; D016253:Microscopy, Immu... | Poultry science | 2,002 | D000907:Antibodies, Bacterial; C016512:IgY; D007136:Immunoglobulins; D011208:Powders |
Influence of the perceived taste intensity of chemesthetic stimuli on swallowing parameters given age and genetic taste differences in healthy adult women. | PURPOSE
This study examined whether the perceived taste intensity of liquids with chemesthetic properties influenced lingua-palatal pressures and submental surface electromyography (sEMG) in swallowing, compared with water.
METHOD
Swallowing was studied in 80 healthy women, stratified by age group and genetic taste s... | 10.1044/1092-4388(2013/13-0005) | 24,687,466 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D061545:Carbonated Water; D019343:Citric Acid; D003679:Deglutition; D004576:Electromyography; D000431:Ethanol; D005260:Female; D006801:Humans; D008875:Middle Aged; D010159:Palate; D011312:Pressure; D013649:Taste; D055697:Taste Perception; D014059:Tongue; D014867:W... | Journal of speech, language, and hearing research : JSLHR | 2,014 | D061545:Carbonated Water; D014867:Water; D019343:Citric Acid; D000431:Ethanol |
Hepatitis C: prevention and treatment. | Widespread screening of donor blood for hepatitis B led to the recognition that most cases of post-transfusion hepatitis were due to an agent or agents, collectively known as non-A, non-B. Until recently, the causative agent for non-A, non-B hepatitis was unknown. In 1988, a new agent, hepatitis C virus, was identified... | 1,901,188 | D001782:Blood Donors; D006526:Hepatitis C; D006801:Humans; D007370:Interferon Type I; D012698:Serologic Tests | American family physician | 1,991 | D007370:Interferon Type I | |
A membrane permeable fluorescent Ca2+ probe based on bis-BODIPY with branched PEG. | A new class of Ca2+ probes is developed based on PEG-BODIPY-BAPTA conjugates. These newly formed probes with BAPTA acid exhibit high sensitivity and selectivity for Ca2+ over other metal ions, can pass through the cell membranes of living cells without special procedures, and can monitor changes in the intracellular Ca... | 10.1039/c4tb01457j | 32,262,180 | Journal of materials chemistry. B | 2,015 | ||
Looking beyond the cancer cell for effective drug combinations. | Combinations of therapies are being actively pursued to expand therapeutic options and deal with cancer's pervasive resistance to treatment. Research efforts to discover effective combination treatments have focused on drugs targeting intracellular processes of the cancer cells and in particular on small molecules that... | 10.1186/s13073-016-0379-8 | 27,887,656 | D000818:Animals; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D019295:Computational Biology; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms; D016019:Survival Analysis;... | Genome medicine | 2,016 | D000970:Antineoplastic Agents |
Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis. | Although the effects of caffeine supplementation on combat sports performance have been extensively investigated, there is currently no consensus regarding its ergogenic benefits.This systematic review with meta-analysis aimed to summarize the studies investigating the effects of caffeine supplementation on different a... | 10.3390/nu14142996 | 35,889,953 | D054874:Athletic Performance; D002110:Caffeine; D019587:Dietary Supplements; D018737:Hand Strength; D058573:Performance-Enhancing Substances; D005082:Physical Exertion; D000076604:Physical Functional Performance | Nutrients | 2,022 | D058573:Performance-Enhancing Substances; D002110:Caffeine |
The System of Objectified Judgement Analysis (SOJA). A tool in rational drug selection for formulary inclusion. | Rational drug selection for formulary purposes is important. Besides rational selection criteria, other factors play a role in drug decision making, such as emotional, personal financial and even unconscious criteria. It is agreed that these factors should be excluded as much as possible in the decision making process.... | 10.2165/00003495-199753040-00002 | 9,098,659 | D002626:Chemistry, Pharmaceutical; D003661:Decision Support Techniques; D004358:Drug Therapy; D006801:Humans | Drugs | 1,997 | |
The effect of delivery type on uncoupling protein-2 levels. | OBJECTIVE
Uncoupling proteins (UCPs) are carrier proteins located in the mitochondrial inner membrane that disturb the proton gradient by re-transporting protons and that thus inhibit ATP synthesis. UCP-2 is found in in several tissues, particularly the brain. This study was performed to examine the effects of mode of ... | 10.3109/14767058.2015.1109619 | 26,479,203 | D002585:Cesarean Section; D036861:Delivery, Obstetric; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D008928:Mitochondria; D011247:Pregnancy; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D000071246:Uncoupling Protein 2 | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | 2,016 | D000071246:Uncoupling Protein 2 |
Synthesis and biological evaluation of 18F-labelled dopamine D3 receptor selective ligands. | The dopamine D3 receptor (D3R) is highly expressed in the limbic regions of the brain and closely related to a variety of neurological disorders including Parkinson's disease, schizophrenia and drug-seeking behavior. In vivo imaging of D3R with radio-labelled tracers and positron emission tomography (PET) has become a ... | 10.1016/j.bmcl.2022.128630 | 35,182,773 | D004298:Dopamine; D005462:Fluorine Radioisotopes; D008024:Ligands; D049268:Positron-Emission Tomography; D050637:Receptors, Dopamine D3; D014018:Tissue Distribution | Bioorganic & medicinal chemistry letters | 2,022 | D005462:Fluorine Radioisotopes; D008024:Ligands; D050637:Receptors, Dopamine D3; D004298:Dopamine |
Checkpoint inhibitor induced myositis - The value of MRI STIR. | •Treatment with immune checkpoint inhibitors can cause serious adverse events.•Myositis combined with myocarditis ad adverse event have a mortality for 50%.•Early diagnosis is important for better outcome.•Employing MRI STIR can rapidly diagnose, guide biopsy, and classify cases of immune-related myositis. | 10.1016/j.ensci.2022.100442 | 36,683,900 | eNeurologicalSci | 2,023 | ||
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. | Although human mast cells express G protein coupled receptors for the anaphylatoxin C3a, previous studies indicated that C3a causes mast cell degranulation, at least in part, via a C3a receptor-independent mechanism similar to that proposed for polycationic molecules such as compound 48/80. The purpose of the present s... | 10.1016/j.ejphar.2011.06.027 | 21,741,965 | D000595:Amino Acid Sequence; D015550:Cell Degranulation; D002460:Cell Line; D015926:Complement C3a; D006801:Humans; D008407:Mast Cells; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-... | European journal of pharmacology | 2,011 | C480039:MRGPRX2 protein, human; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; C510803:mas-related gene-X1 receptor, human; D003189:p-Methoxy-N-methylphenethylamine; D015926:... |
An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats. | The effects of glucagon on the ultrastructural appearance and acid glucosidase activities in the liver and heart of newborn rats were studied. Liver or heart glycogen-hydrolyzing activity of acid glucosidase increased 3 hours after birth and gradually decreased from 3 to 9 hours. Maltose-hydrolyzing activity of acid gl... | 10.1002/jemt.20000 | 14,722,905 | D000818:Animals; D000831:Animals, Newborn; D001343:Autophagy; D005934:Glucagon; D005959:Glucosidases; D006003:Glycogen; D006321:Heart; D022781:Hepatocytes; D008099:Liver; D008320:Maltose; D008854:Microscopy, Electron; D009206:Myocardium; D011500:Protein Synthesis Inhibitors; D051381:Rats; D013997:Time Factors | Microscopy research and technique | 2,004 | D011500:Protein Synthesis Inhibitors; D008320:Maltose; D006003:Glycogen; D005934:Glucagon; D005959:Glucosidases |
Factors affecting UV/H2O2 inactivation of Bacillus atrophaeus spores in drinking water. | This study aims at estimating the performance of the Bacillus atrophaeus spores inactivation by the UV treatment with addition of H2O2. The effect of factors affecting the inactivation was investigated, including initial H2O2 dose, UV irradiance, initial cell density, initial solution pH and various inorganic anions. U... | 24,792,469 | D000838:Anions; D001407:Bacillus; D060766:Drinking Water; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D013171:Spores, Bacterial; D013997:Time Factors; D014466:Ultraviolet Rays; D018508:Water Purification | Journal of photochemistry and photobiology. B, Biology | 2,014 | D000838:Anions; D060766:Drinking Water; D006861:Hydrogen Peroxide | |
Validation of a new dental plaque quantification method in dogs. | Current methods for the quantification of plaque accumulation in cats and dogs are well-accepted adaptations of traditional human models, but have required substantial modifications in order to compensate for the inherent differences in compliance, cooperation, and temperament between animals and humans. While these mo... | 10.1177/089875640702400103 | 17,500,484 | D000818:Animals; D003773:Dental Plaque; D003774:Dental Plaque Index; D004283:Dog Diseases; D004285:Dogs; D015203:Reproducibility of Results | Journal of veterinary dentistry | 2,007 | |
Sleep-disordered breathing among women with fibromyalgia syndrome. | BACKGROUND
In clinical practice, polysomnograms ("sleep studies") are seldom ordered for patients with fibromyalgia, although sleep issues dominate the symptom complex. One reason for this is the lack of understanding how information from these studies could aid clinical decisions.
METHODS
The authors conducted a cha... | 10.1097/01.rhu.0000249771.97221.36 | 17,149,057 | D001049:Apnea; D015992:Body Mass Index; D005260:Female; D005356:Fibromyalgia; D006801:Humans; D008875:Middle Aged; D017286:Polysomnography; D012119:Respiration; D012893:Sleep Wake Disorders | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases | 2,006 | |
A new variant of cytolethal distending toxin in a clinical isolate of Campylobacter hyointestinalis. | Increasing numbers of Campylobacter hyointestinalis have been isolated from humans and animals with gastroenteritis, although the virulence mechanism of this species remains largely unknown. Here, we show that C. hyointestinalis isolated from a patient with diarrhoea in Thailand produced a novel variant of cytolethal d... | 10.1099/jmm.0.000145 | 26,220,191 | D001427:Bacterial Toxins; D002169:Campylobacter Infections; D044862:Campylobacter hyointestinalis; D002470:Cell Survival; D004269:DNA, Bacterial; D003967:Diarrhea; D004847:Epithelial Cells; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017422:Sequence A... | Journal of medical microbiology | 2,015 | D001427:Bacterial Toxins; D004269:DNA, Bacterial; C067044:cytolethal distending toxin |
Mechanism of fibrosis in experimental tacrolimus nephrotoxicity. | The clinical use of tacrolimus (FK506) is limited by nephrotoxicity. The pathogenesis of fibrosis in chronic FK506 nephrotoxicity remains unknown. Because transforming growth factor (TGF)-beta plays a key role in the fibrogenesis of many diseases, including cyclosporine nephrotoxicity, we studied a salt-depleted rat mo... | 10.1097/00007890-199712270-00034 | 9,422,427 | D000818:Animals; D005109:Extracellular Matrix; D016326:Extracellular Matrix Proteins; D005355:Fibrosis; D019084:Fluorescent Antibody Technique, Indirect; D015870:Gene Expression; D007672:Kidney Cortex; D007674:Kidney Diseases; D007679:Kidney Medulla; D008297:Male; D017395:Plasminogen Activator Inhibitor 1; D051381:Rats... | Transplantation | 1,997 | D016326:Extracellular Matrix Proteins; D017395:Plasminogen Activator Inhibitor 1; D017673:Sodium Chloride, Dietary; D019063:Tenascin; D016212:Transforming Growth Factor beta; D012083:Renin; D016559:Tacrolimus |
Reaction of neurons of arcuate region of hypothalamus to microiontophoretic application of serotonin at different stages of the estrous cycle in rats. | Sensitivity to serotonin was investigated in single neurons of the arcuate region of the hypothalamus as the center of tonic regulation of gonadotropic function in conditions of its microiontophoretic application in different stages of the estrous cycle in rats. It was shown that at the diestrus-II stage of the estrous... | 10.1007/BF01186883 | 3,736,834 | D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus; D004971:Estrus; D005260:Female; D007478:Iontophoresis; D007986:Luteinizing Hormone; D009474:Neurons; D051381:Rats; D012701:Serotonin | Neuroscience and behavioral physiology | 1,986 | D012701:Serotonin; D007986:Luteinizing Hormone |
Genital ulcer disease. | Preview What are the main causes of genital ulcer disease in the United States? Why is clinical diagnosis so difficult? What role will molecular diagnostics have in the future? The authors answer these questions and provide a functional approach to successful management of three common types of sexually transmitted gen... | 10.1080/00325481.1995.11946043 | 29,231,097 | Postgraduate medicine | 1,995 | ||
Evolution of Antibiotic Use and Cost in Patients with Community-Acquired Pneumonia. | OBJECTIVE
To investigate the evolution and efficiency of the clinical management (particularly shift therapy) of patients with community-acquired pneumonia (CAP) in a hospital setting.
STUDY DESIGN AND METHODS
This was a retrospective analysis of 120 hospitalised patients who were treated with antibiotics for CAP in ... | 10.2165/00044011-200222090-00005 | 29,492,854 | Clinical drug investigation | 2,002 | ||
Post-imatinib surgery in advanced/metastatic GIST: is it worthwhile in all patients? | BACKGROUND
Surgical indication for metastatic gastrointestinal stromal tumor (GIST) treated with imatinib is not yet established.
MATERIALS AND METHODS
We analyzed 80 patients who underwent surgery for metastatic GIST after imatinib therapy from July 2002 to October 2007. Patients were divided into those with surgery... | 10.1093/annonc/mdp310 | 19,628,568 | D000970:Antineoplastic Agents; D001549:Benzamides; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors; D006801:Humans; D000... | Annals of oncology : official journal of the European Society for Medical Oncology | 2,010 | D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate |
The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve. | The obligate intracellular protozoan parasite Toxoplasma gondii creates and enters into a unique membrane-bounded cytoplasmic compartment, the parasitophorous vacuole, when invading mammalian host cells. By microinjecting polar fluorescent molecules into individual T. gondii-infected fibroblasts, we show here that the ... | 10.1073/pnas.91.2.509 | 8,290,555 | D000595:Amino Acid Sequence; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium; D002478:Cells, Cultured; D003593:Cytoplasm; D005347:Fibroblasts; D016650:Fluorescein-5-isothiocyanate; D006801:Humans; D007425:Intracellular Membranes; D007546:Isoquinolines; D008845:Microinjections; D008856:Microscopy,... | Proceedings of the National Academy of Sciences of the United States of America | 1,994 | D007546:Isoquinolines; D015335:Molecular Probes; D010455:Peptides; C017475:lucifer yellow; D016650:Fluorescein-5-isothiocyanate; D002118:Calcium |
Sero-prevalence and associated risk factors of Toxoplasma gondii infection among pregnant women attending antenatal care at Felege Hiwot Referral Hospital, northwest Ethiopia. | OBJECTIVE
To determine the prevalence of toxoplasmosis and to assess the possible risk factors associated with the infection among pregnant women attending antenatal care center at Felege Hiwot Referral Hospital, Bahir Dar town, northwest Ethiopia.
METHODS
A hospital based cross-sectional study was designed to determ... | 26,276,286 | Asian Pacific journal of tropical medicine | 2,015 | |||
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p. | Cytochrome P450 1A2 (CYP1A2) is one of the most abundant and important drug metabolizing enzymes in human liver. However, little is known about the post-transcriptional regulation of CYP1A2, especially the mechanisms involving microRNAs (miRNAs). This study applied a systematic approach to investigate the post-transcri... | 10.1016/j.bcp.2017.08.012 | 28,822,783 | D018931:Antineoplastic Agents, Hormonal; D002460:Cell Line; D049109:Cell Proliferation; D003198:Computer Simulation; D019388:Cytochrome P-450 CYP1A2; D005485:Flutamide; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D064747:Lansoprazole; D035683:MicroRNAs; D054328:Proton Pump Inhibitors; D012323:RNA P... | Biochemical pharmacology | 2,017 | D018931:Antineoplastic Agents, Hormonal; D035683:MicroRNAs; D054328:Proton Pump Inhibitors; D012333:RNA, Messenger; D064747:Lansoprazole; D005485:Flutamide; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2 |
Risks and Benefits of Increased Nut Consumption: Cardiovascular Health Benefits Outweigh the Burden of Carcinogenic Effects Attributed to Aflatoxin B₁ Exposure. | Nuts are rich in nutrients and mounting evidence shows that consumption reduces cardiovascular disease (CVD) incidence. Nuts may also be a major source of aflatoxin B₁, a potent liver carcinogen and the risk/benefit balance is unknown. Based on national statistics and data from the PREDIMED intervention trial, we estim... | 10.3390/nu9121355 | 29,236,075 | D016604:Aflatoxin B1; D002273:Carcinogens; D002318:Cardiovascular Diseases; D002319:Cardiovascular System; D004034:Diet Surveys; D005260:Female; D005506:Food Contamination; D005516:Food Microbiology; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms; D008297:Male; D018977:Micronutrients; D008875:Middle Aged; D... | Nutrients | 2,017 | D002273:Carcinogens; D018977:Micronutrients; D016604:Aflatoxin B1 |
Efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation and chronic kidney disease. | BACKGROUND
Direct oral anticoagulants (DOACs) are effective alternatives to warfarin for stroke prevention in patients with atrial fibrillation (AF) including patients with CKD III. However, data on patient outcomes with DOACs for advanced CKD are limited, while warfarin use is controversial.
METHODS
A retrospective ... | 10.1111/pace.13811 | 31,599,969 | D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants; D001281:Atrial Fibrillation; D004617:Embolism; D065427:Factor Xa Inhibitors; D005260:Female; D006470:Hemorrhage; D006801:Humans; D007676:Kidney Failure, Chronic; D008297:Male; D051436:Renal Insufficiency, Chronic; D012189:Retrospective Studies; D020521:St... | Pacing and clinical electrophysiology : PACE | 2,019 | D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D014859:Warfarin |
[The XPS of complexes of zinc salts with alpha-amino acids]. | The XPS of solid complexes of ZnCl2/ZnSO4/ZnOAc2 with alpha-Met/His have been investigated. The results indicate that Zn2+ coordinate with O atom of carboxyl group and N atom of alpha-amino. The N atom of imidazolyl also participates the coordination. While the S atom of methylthio does not coordinate with Zn2+. This r... | 12,953,584 | D000596:Amino Acids; D002614:Chelating Agents; D006639:Histidine; D008715:Methionine; D015394:Molecular Structure; D009942:Organometallic Compounds; D015032:Zinc; D017967:Zinc Compounds | Guang pu xue yu guang pu fen xi = Guang pu | 2,001 | D000596:Amino Acids; D002614:Chelating Agents; D009942:Organometallic Compounds; D017967:Zinc Compounds; D006639:Histidine; D008715:Methionine; D015032:Zinc | |
[Analysis of the secondary structure of the regulatory region of mRNA of the Escherichia coli rpsA gene]. | The rpsA gene of E. coli coding for the ribosomal protein S1 was inserted into the plasmid pGEM-3Z under the control of a T7 promoter. The resulted plasmid was used for mRNA preparation in vitro. The toeprint analysis of the rpsA mRNA revealed a strong S1 dependence: 30S ribosomal subunits lacking S1 were inactive in t... | 8,274,171 | D001483:Base Sequence; D004926:Escherichia coli; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010957:Plasmids; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D012045:Regulatory Sequences, Nucleic Acid; D012269:Ribosomal Proteins | Bioorganicheskaia khimiia | 1,993 | D012269:Ribosomal Proteins; C015494:ribosomal protein S1 | |
[Liver transplantation in patients with hepatocellular carcinoma]. | Hepatocellular carcinoma (HCC) is the third most common malignancy, with a new incidence of more than 11,000 cases per year and the second most common cause of malignancy-related death in Korean males. In Korea, more than 80% of all HCCs have developed from hepatitis B virus (HBV)-related cirrhotic livers. Liver transp... | 201006252 | 20,571,302 | D015415:Biomarkers; D006528:Carcinoma, Hepatocellular; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D016031:Liver Transplantation; D008297:Male; D009367:Neoplasm Staging; D012008:Recurrence; D012720:Severity of Illness Index | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi | 2,010 | D015415:Biomarkers |
Evaluating photographic scales of facial pores and diagnostic agreement of tests using latent class models. | BACKGROUND
Ordinal severity scales illustrated by photographs have been widely developed to help dermatologists in evaluating skin problems or improvements. Numerous scales have been published, and none of them were used for assessing facial pores.
METHODS
A five-point photographic scale of facial pores was formulate... | 10.1080/14764172.2016.1247969 | 27,775,445 | D000328:Adult; D005260:Female; D006801:Humans; D015233:Models, Statistical; D009666:Nose; D015588:Observer Variation; D010781:Photography; D011336:Probability; D015203:Reproducibility of Results; D012867:Skin; D015595:Skin Aging | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology | 2,017 | |
In vitro Cleavage and Electrophoretic Mobility Shift Assays for Very Fast CRISPR. | CRISPR-Cas9 has transformed biomedical research and medicine through convenient and targeted manipulation of DNA. Time- and spatially-resolved control over Cas9 activity through the recently developed very fast CRISPR (vfCRISPR) system have facilitated comprehensive studies of DNA damage and repair. Understanding the f... | 10.21769/BioProtoc.4138 | 34,604,444 | Bio-protocol | 2,021 | ||
Positive selection versus demography: evolutionary inferences based on an unusual haplotype structure in Drosophila simulans. | Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of Drosophila simulans displaying an unusual large-scale haplotype structure. The multilocus analysis, based on summary statistics using specifi... | 10.1093/molbev/msl031 | 16,757,657 | D000818:Animals; D005075:Biological Evolution; D003710:Demography; D004330:Drosophila; D006239:Haplotypes; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic; D012641:Selection, Genetic | Molecular biology and evolution | 2,006 | |
Gastric volvulus associated with agenesis of the left lobe of the liver in a child: a case treated by laparoscopic gastropexy. | Association of gastric volvulus with agenesis of the left lobe of the liver is very rare and mostly reported in adults. We report a case of gastric volvulus associated with agenesis of the left lobe of the liver in a child, which was successfully treated by laparoscopic gastropexy. | 10.1016/j.jpedsurg.2007.09.072 | 18,206,488 | D000015:Abnormalities, Multiple; D002675:Child, Preschool; D013505:Digestive System Surgical Procedures; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D010535:Laparoscopy; D008099:Liver; D008297:Male; D011860:Ra... | Journal of pediatric surgery | 2,008 | |
Treatment of monozygotic twins with obsessive compulsive disorder using cognitive therapy and exposure with ritual prevention. | BACKGROUND
Assessment and treatment of cohabiting monozygotic (MZ) twins with obsessive compulsive disorder (OCD) is a possible challenge for clinical psychologists.
AIMS
This study aims to present a detailed history of two sets of cohabiting MZ twins with OCD, and describe the adaption of cognitive behavior therapy ... | 10.1017/S1352465809990117 | 19,563,690 | D000328:Adult; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder; D014430:Twins, Monozygotic | Behavioural and cognitive psychotherapy | 2,009 | |
Outcome of penile revascularization for arteriogenic erectile dysfunction after pelvic fracture urethral injuries. | OBJECTIVE
To review our experience with penile revascularization for patients with bilateral occlusion of the deep internal pudendal arteries after pelvic fracture urethral injury (PFUI).
MATERIALS AND METHODS
We identified 17 patients who had undergone penile revascularization with end-to-side anastomosis of the dee... | 23,206,787 | D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D001157:Arterial Occlusive Diseases; D019074:Epigastric Arteries; D006801:Humans; D018783:Impotence, Vasculogenic; D008297:Male; D008875:Middle Aged; D010413:Penis; D012189:Retrospective Studies; D012421:Rupture; D014521:Urethra; D055815:Young Adult | Urology | 2,012 | ||
Two sides of the same coin? Rare and pest plants native to the United States and Canada. | Plant biodiversity is at risk, with as many as 10% of native species in the United States being threatened with extinction. Habitat loss has led a growing number of plant species to become rare or threatened, while the introduction or expansion of pest species has led some habitats to be dominated by relatively few, mo... | 10.1890/11-1915.1 | 22,908,710 | D002170:Canada; D003247:Conservation of Natural Resources; D003710:Demography; D017753:Ecosystem; D006802:Human Activities; D058865:Introduced Species; D010802:Phylogeny; D063245:Plant Development; D010944:Plants; D011003:Ploidies; D014481:United States | Ecological applications : a publication of the Ecological Society of America | 2,012 | |
Food intake, its relationship to body weight and age, and its apparent nutritional adequacy in New Guinean children. | Previous nutritional investigations in New Guinea have shown low intakes of protein and of energy yet the nutritional status of children and their ability to thrive have been regarded as better than could be expected. To investigate this apparent paradox, the dietary intakes of 482 New Guinean children, aged 1-18 years... | 10.1093/ajcn/28.12.1443 | 803,007 | D000293:Adolescent; D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009512:New Guinea; D009749:Nutrition Surveys; D009752:Nutritional Status | The American journal of clinical nutrition | 1,975 | |
Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease. | Lipids play an important role as risk or protective factors in Alzheimer's disease (AD). Previously it has been shown that plasmalogens, the major brain phospholipids, are altered in AD. However, it remained unclear whether plasmalogens themselves are able to modulate amyloid precursor protein (APP) processing or if th... | 10.1100/2012/141240 | 22,547,976 | D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor; D001921:Brain; D002460:Cell Line; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010955:Plasmalogens; D011499:Protein Processing, Post-Translatio... | TheScientificWorldJournal | 2,012 | D016564:Amyloid beta-Protein Precursor; D010955:Plasmalogens; D012313:RNA; D053829:Amyloid Precursor Protein Secretases |
Analytical design of modified Smith predictor in a two-degrees-of-freedom control scheme for second order unstable processes with time delay. | A modified form of Smith predictor is designed for controlling unstable second order plus time delay (USOPTD) processes, with/without a zero. USOPTD process transfer functions arise in modeling of many chemical and biological systems, such as isothermal continuous stirred tank reactors (CSTR) carrying out autocatalytic... | 10.1016/j.isatra.2008.06.005 | 18,706,559 | ISA transactions | 2,008 | ||
Oligoclonal expansion of CD4(+)CD28(-) T lymphocytes in recipients of allogeneic hematopoietic cell grafts and identification of the same T cell clones within both CD4(+)CD28(+) and CD4(+)CD28(-) T cell subsets. | Recipients of allogeneic bone marrow grafts have clonally expanded CD8(+)CD28(-) T lymphocytes during the early period after transplantation, which leads to skewing of T cell receptor (TCR) repertoires. Here, we have addressed the question of whether clonal expansion of CD28(-) T cells is also observed in CD4(+) T lymp... | 10.1038/sj.bmt.1703045 | 11,438,827 | D000595:Amino Acid Sequence; D018106:CD28 Antigens; D015496:CD4-Positive T-Lymphocytes; D002455:Cell Division; D019070:Cell Lineage; D002999:Clone Cells; D022801:Complementarity Determining Regions; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016176:... | Bone marrow transplantation | 2,001 | D018106:CD28 Antigens; D022801:Complementarity Determining Regions; D016693:Receptors, Antigen, T-Cell, alpha-beta |
SHRSP/Izm and WKY/NCrlCrlj rats having a missense mutation in Abcg5 deposited plant sterols in the body, but did not change their biliary secretion and lymphatic absorption-comparison with Jcl:Wistar and WKY/Izm rats. | We had previously found plant sterols deposited in the bodies of stroke-prone spontaneously hypertensive rats (SHRSP)/Sea and Wistar Kyoto (WKY)/NCrlCrlj rats that had a missense mutation in the Abcg5 cDNA sequence that coded for ATP-binding cassette transporter (ABC) G5. We used SHRSP/Izm, WKY/NCrlCrlj, and WKY/Izm ra... | 10.1271/bbb.110667 | 22,484,926 | D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters; D000042:Absorption; D019943:Amino Acid Substitution; D000818:Animals; D001646:Bile; D001794:Blood Pressure; D006973:Hypertension; D008074:Lipoproteins; D042601:Lymphatic Vessels; D008297:Male; D020125:Mutation... | Bioscience, biotechnology, and biochemistry | 2,012 | D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters; C480692:Abcg5 protein, rat; D008074:Lipoproteins; D009711:Nucleotides; D010840:Phytosterols |
Therapeutic hypothermia in term infants after perinatal encephalopathy: the last 5 years in Switzerland. | BACKGROUND
Therapeutic hypothermia (TH) following perinatal asphyxial encephalopathy in term infants improves mortality and neurodevelopmental outcome. In Europe, most neonatal units perform active cooling whereas in Switzerland passive cooling is predominantly used.
AIMS
(i) To determine how many infants were cooled... | 23,116,611 | D000704:Analysis of Variance; D001238:Asphyxia Neonatorum; D001831:Body Temperature; D004569:Electroencephalography; D006801:Humans; D007036:Hypothermia, Induced; D002534:Hypoxia, Brain; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D012189:Retrospective Studies; D013557:Switzerland | Early human development | 2,013 | ||
Neonatal atypical hemolytic uremic syndrome due to methylmalonic aciduria and homocystinuria. | BACKGROUND
Inborn errors of cobalamin (Cbl) absorption and metabolism form a large group of rare diseases that include Cbl-C disorder. Among the renal complications of Cbl-C disorder, atypical hemolytic uremic syndrome (HUS) is the least common and has been described only in a small number of cases.
CASE-DIAGNOSIS/TR... | 10.1007/s00467-012-2152-6 | 22,447,314 | D000592:Amino Acid Metabolism, Inborn Errors; D065766:Atypical Hemolytic Uremic Syndrome; D002352:Carrier Proteins; D006463:Hemolytic-Uremic Syndrome; D006712:Homocystinuria; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010088:Oxidoreductases; D014806:Vitamin B 12 Deficiency | Pediatric nephrology (Berlin, Germany) | 2,012 | D002352:Carrier Proteins; C508359:MMACHC protein, human; D010088:Oxidoreductases |
Evaluation of SBRC-gastric and SBRC-intestinal methods for the prediction of in vivo relative lead bioavailability in contaminated soils. | In this study, lead (Pb) bioaccessibility in contaminated soils was assessed using an in vitro method (SBRC) encompassing gastric (SBRC-G) and intestinal (SBRC-I) phases. Initially, bioaccessibility studies were performed with a Pb reference material (Pb acetate, 1-10 mg L(-1)) in order to determine the influence of pH... | 10.1021/es803238u | 19,603,669 | D000818:Animals; D001682:Biological Availability; D004784:Environmental Monitoring; D005260:Female; D005753:Gastric Mucosa; D007413:Intestinal Mucosa; D007854:Lead; D008954:Models, Biological; D012989:Soil Pollutants; D013552:Swine | Environmental science & technology | 2,009 | D012989:Soil Pollutants; D007854:Lead |
Higher vitamin D levels in HIV-infected out-patients on treatment with boosted protease inhibitor monotherapy. | OBJECTIVES
We investigated the vitamin D status of patients receiving frequently used types of combination antiretroviral therapy (cART), including boosted protease inhibitor (PI) monotherapy.
METHODS
For this cross-sectional study, out of 450 HIV-infected patients followed in the Hospital Severo Ochoa (Madrid, Spain... | 10.1111/hiv.12049 | 23,738,846 | D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D044383:Black People; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections; D017320:HIV Protease Inhibitors; D006370:Heliotherapy; D006801:Humans; D008297:Male; D010045:Outpatients; D013030:Spain; D019562:Viral Load; D014807:Vitamin D; D01... | HIV medicine | 2,013 | D017320:HIV Protease Inhibitors; D014807:Vitamin D |
Determination of insulin resistance in surgery: the choice of method is crucial. | BACKGROUND & AIMS
In elective surgery, postoperative hyperglycaemia and insulin resistance are independent risk factors for complications. Since the simpler HOMA method has been used as an alternative to the hyperinsulinemic normoglycemic clamp in studies of surgery induced insulin resistance, we compared the two metho... | 24,581,942 | D000328:Adult; D000368:Aged; D017558:Elective Surgical Procedures; D005260:Female; D015309:Glucose Clamp Technique; D006706:Homeostasis; D006801:Humans; D006943:Hyperglycemia; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preopera... | Clinical nutrition (Edinburgh, Scotland) | 2,015 | ||
Prevalence of insulin resistance in Korean women with polycystic ovary syndrome according to various homeostasis model assessment for insulin resistance cutoff values. | OBJECTIVE
To investigate the various homeostasis model assessment for insulin resistance (HOMA-IR) cutoff values in a large population of healthy controls and to evaluate the prevalence of IR in women with polycystic ovary syndrome (PCOS).
DESIGN
Case control study.
SETTING
Reproductive endocrinology center.
PATI... | 10.1016/j.fertnstert.2019.06.035 | 31,542,165 | D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome; D015995:Prevalence; D056910:Republic of Korea; D055815:Young Adult | Fertility and sterility | 2,019 | |
[Magnetic resonance-ultrasound fusion guided transperineal prostate biopsy for the diagnosis of prostate cancer]. | OBJECTIVE
To investigate the application value of magnetic resonance-ultrasound fusion (MR-USF) guided transperineal prostate biopsy (TPPB) in the diagnosis of prostate cancer.
METHODS
Relevant data were collected retrospectively from 77 patients undergoing MR-USF guided TPPB (n = 22) or 12-core systematic prostate b... | 34,898,070 | D006801:Humans; D061705:Image-Guided Biopsy; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011446:Prospective Studies; D011467:Prostate; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional | Zhonghua nan ke xue = National journal of andrology | 2,020 | ||
Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever. | Interleukin (IL)-13 is produced by T helper 2 (Th2)-type cells and inhibits the production of proinflammatory cytokines by activated monocytes, while IL-18 is a pleiotropic cytokine that induces interferon-gamma and plays an important role in the development of Th1-type cells. Role of the shift from a Th1-type response... | 10.1111/j.1574-695X.2001.tb01575.x | 11,335,143 | D006801:Humans; D018793:Interleukin-13; D020382:Interleukin-18; D011379:Prognosis; D019595:Severe Dengue | FEMS immunology and medical microbiology | 2,001 | D018793:Interleukin-13; D020382:Interleukin-18 |
Toxic effect of silver and platinum nanoparticles toward the freshwater microalga Pseudokirchneriella subcapitata. | The growing use of nanoparticles in a wide range of products has resulted in their release into the aquatic environment; therefore, an understanding of the toxic effects of nanoparticles on aquatic organisms is of permanent importance. The aim of this study was to evaluate the toxicity of silver and platinum nanopartic... | 10.1007/s00128-015-1505-9 | 25,742,926 | D059001:Aquatic Organisms; D002734:Chlorophyll; D000460:Chlorophyta; D005618:Fresh Water; D053758:Nanoparticles; D010788:Photosynthesis; D010984:Platinum; D012834:Silver; D014874:Water Pollutants, Chemical | Bulletin of environmental contamination and toxicology | 2,015 | D014874:Water Pollutants, Chemical; D002734:Chlorophyll; D012834:Silver; D010984:Platinum |
Prognostic and Predictive Factors in Elderly Patients With Glioblastoma: A Single-Center Retrospective Study. | Glioblastoma (GBM) is the most common primary malignant intracranial tumor and the median age at diagnosis is 65 years. However, elderly patients are usually excluded from clinical studies and age is considered as an independent negative prognostic factor for patients with GBM. Therefore, the best treatment method for ... | 10.3389/fnagi.2021.777962 | 35,173,600 | Frontiers in aging neuroscience | 2,021 | ||
Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. | Interleukin-10 (IL-10) is an acid-sensitive protein of 35 kD that has pleiotropic effects including inhibition of cytotoxic T-cell response, induction of major histocompatibility complex type II in B lymphocytes, induction of B-cell growth and differentiation, and autocrine growth factor activity in monocytes. We and o... | 7,780,129 | D001402:B-Lymphocytes; D001483:Base Sequence; D002455:Cell Division; D006801:Humans; D016753:Interleukin-10; D016483:Lymphoma, AIDS-Related; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured | Blood | 1,995 | D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D011994:Recombinant Proteins; D016753:Interleukin-10 | |
A budget impact analysis of bezlotoxumab versus standard of care antibiotics only in patients at high risk of CDI recurrence from a hospital management perspective in Germany. | BACKGROUND
Clostridioides difficile infection (CDI) is one of the leading nosocomial infections, resulting in increased hospital length of stay and additional treatment costs. Bezlotoxumab, the first monoclonal antibody against CDI, has an 1 A guideline recommendation for prevention of CDI, after randomized clinical tr... | 10.1186/s12913-021-06970-8 | 34,496,836 | D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000080908:Broadly Neutralizing Antibodies; D016360:Clostridioides difficile; D005858:Germany; D006761:Hospitals; D006801:Humans; D012008:Recurrence; D059039:Standard of Care | BMC health services research | 2,021 | D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000080908:Broadly Neutralizing Antibodies; C000613978:bezlotoxumab |
Responsiveness and minimal important change of the Oxford Shoulder Score, EQ-5D, and the Fear-Avoidance Belief Questionnaire Physical Activity subscale in patients undergoing arthroscopic subacromial decompression. | INTRODUCTION
Adequate responsiveness and knowledge of the minimal important change (MIC) is essential when using patient-reported outcome measures to assess treatment efficacy.
OBJECTIVE
The objective of this study was to evaluate the responsiveness and MIC of common outcomes in patients with subacromial impingement ... | 10.1016/j.jseint.2021.05.008 | 34,505,098 | JSES international | 2,021 | ||
Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV. | (-)-Cannabidiol [(-)-CBD] has recently gained prominence as a treatment for neuro-inflammation and other neurodegenerative disorders; interest is also developing in its synthetic enantiomer, (+)-CBD, which has a higher affinity to CB1 / CB2 receptors than the natural stereoisomer. We have developed an inexpensive, ster... | 10.1016/j.tetlet.2021.152891 | 34,658,452 | Tetrahedron letters | 2,021 | ||
Low-amplitude, low-frequency electric field-stimulated bone cell proliferation may in part be mediated by increased IGF-II release. | We have developed an in vitro model incorporating a low-amplitude (10(-7) V/cm), low frequency (f less than 100 Hz), capacitively coupled electric field in order to study the mechanism through which an electric field may increase bone cell proliferation. Utilizing this model we have previously shown that electric field... | 10.1002/jcp.1041500112 | 1,730,789 | D001842:Bone and Bones; D002455:Cell Division; D004558:Electric Stimulation; D006801:Humans; D007335:Insulin-Like Growth Factor II; D007700:Kinetics; D012516:Osteosarcoma; D012333:RNA, Messenger; D014407:Tumor Cells, Cultured | Journal of cellular physiology | 1,992 | D012333:RNA, Messenger; D007335:Insulin-Like Growth Factor II |
Activity of different revertant agents on multidrug resistance: in vitro evaluation of their combination. | The revertant activity of different compounds has been assayed on a multidrug-resistant human breast-cancer cell line (MCF 7/Dx). The calcium-channel blocker nicardipine showed the higher revertant ability when compared to cefoperazone or cyclosporin A at concentrations close to the pharmacological range. Interestingly... | 7,904,261 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D002438:Cefoperazone; D002455:Cell Division; D016572:Cyclosporine; D004317:Doxorubicin; D004351:Drug Resistance; D006801:Humans; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009529:Nicardipine; D012333:RNA, Messeng... | International journal of tissue reactions | 1,993 | D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D002438:Cefoperazone; D004317:Doxorubicin; D016572:Cyclosporine; D009529:Nicardipine; D013936:Thymidine | |
Inhibition of norepinephrine and caffeine-induced activation by ryanodine and thapsigargin in rat mesenteric arteries. | We examined the effects of ryanodine and thapsigargin on changes in cytoplasmic [Ca2+] (Cai) and muscle tension in rat mesenteric resistance arteries induced by norepinephrine (NE) and caffeine. Both ryanodine and thapsigargin markedly inhibited the increase in Cai and contractile responses to caffeine in physiological... | 10.1097/00005344-199505000-00022 | 7,630,163 | D000818:Animals; D002110:Caffeine; D002118:Calcium; D000252:Calcium-Transporting ATPases; D003593:Cytoplasm; D004305:Dose-Response Relationship, Drug; D008297:Male; D008638:Mesenteric Arteries; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular; D009638:Norepinephrine; D051381:Rats; D017207:Rats, Sprague-Dawl... | Journal of cardiovascular pharmacology | 1,995 | D013729:Terpenes; D012433:Ryanodine; D002110:Caffeine; D019284:Thapsigargin; D000252:Calcium-Transporting ATPases; D002118:Calcium; D009638:Norepinephrine |
Efficacy and Safety of Vasopressin as First-Line Treatment of Distributive and Hemorrhagic Shock States. | Background: Norepinephrine remains the first-line option to manage patients with circulatory shock. Limited evidence exists evaluating noncatecholamine compounds as first-line monotherapy for managing noncardiogenic shock. Objective: To compare vasopressin monotherapy with norepinephrine monotherapy for reversal of dis... | 10.1177/1060028019882035 | 31,625,395 | D000328:Adult; D001794:Blood Pressure; D015331:Cohort Studies; D003404:Creatinine; D005260:Female; D006339:Heart Rate; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine; D016016:Proportional Hazards Models; D012189:Retros... | The Annals of pharmacotherapy | 2,020 | D014662:Vasoconstrictor Agents; D014667:Vasopressins; D019344:Lactic Acid; D003404:Creatinine; D009638:Norepinephrine |
[Exeresis of reparative giant cell granuloma: intentional section of the inferior dental nerve followed by its repair]. | The authors report the case of a nine year old girl, who was treated for a giant cell reparative granuloma of the right mandible. Surgical excision of this tumor was accomplished via a transoral approach and intentional division of the mental neurovascular bundle. Immediate gross repair of the nerve was carried out at ... | 3,470,876 | D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell; D006801:Humans; D008336:Mandibular Diseases; D008340:Mandibular Nerve; D008722:Methods; D011859:Radiography; D013997:Time Factors; D014070:Tooth | Revue de stomatologie et de chirurgie maxillo-faciale | 1,986 | ||
Stimulation of murine cultured mast cells under anaerobic conditions: inhibition of arachidonic acid release. | The exocytosis of beta-hexosaminidase from either IgE-antigen- or calcium ionophore A23187-stimulated murine bone-marrow-derived mast cells was not affected by oxygen-depleted conditions regardless of the absence of glucose from the medium. No detectable changes in the content of ATP were observed when the cells were t... | 10.1016/0165-2478(87)90118-0 | 3,123,379 | D000255:Adenosine Triphosphate; D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D000941:Antigens; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D000001:Calcimycin; D002478:Cells, Cultured; D007073:Immunoglobulin E; D008407:Mast Cells; D051379:Mice | Immunology letters | 1,987 | D000941:Antigens; D001095:Arachidonic Acids; D016718:Arachidonic Acid; D007073:Immunoglobulin E; D000001:Calcimycin; D000255:Adenosine Triphosphate |
Bound valley edge states in the continuum. | Topological valley photonics provides a unique way to manipulate the flow of light. In general, valley edge states that exhibit unidirectional propagation and are immune to defects and disorders could be realized at the interface between two valley photonic crystals with opposite valley Chern numbers. Herein, by mergin... | 10.1364/OL.463458 | 35,709,062 | Optics letters | 2,022 | ||
Oxidative phosphorylation in rat skeletal muscles after space flight on board biosatellites. | Polarographic analysis of biological oxidation in rat's skeletal muscles after the 18- and 22-day flights revealed changes specific for the flight animals: oxidative phosphorylation uncoupling, distinct inertness of energy accumulation after 10 hrs of landing. Tissue respiration's inhibition was observed in both flight... | 11,540,674 | D000818:Animals; D001081:Apyrase; D004734:Energy Metabolism; D007521:Isocitrate Dehydrogenase; D008291:Malate Dehydrogenase; D008931:Mitochondria, Muscle; D018763:Muscle Fatigue; D018482:Muscle, Skeletal; D010088:Oxidoreductases; D010101:Oxygen Consumption; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D... | Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology | 1,997 | D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001081:Apyrase | |
Integrated magnetic tweezers and single-molecule FRET for investigating the mechanical properties of nucleic acid. | Many enzymes promote structural changes in their nucleic acid substrates via application of piconewton forces over nanometer length scales. Magnetic tweezers (MT) is a single molecule force spectroscopy method widely used for studying the energetics of such mechanical processes. MT permits stable application of a wide ... | 27,320,203 | D004247:DNA; D031541:Fluorescence Resonance Energy Transfer; D008280:Magnetics; D055595:Mechanical Phenomena; D009690:Nucleic Acid Conformation; D052898:Optical Tweezers; D000072760:Single Molecule Imaging | Methods (San Diego, Calif.) | 2,016 | D004247:DNA | |
Effect of Protease Combined with Heat Treatment on the Volatile Composition and Aroma Quality in Liqueur Wine. | The aim of this paper was to compare the effects of two clarification methods, protease combined with heat treatment and bentonite, on the aroma quality of liqueur wines, and to identify and analyze the overall differences between the basic components and volatile aroma compounds of liqueur wines after the two treatmen... | 10.3390/molecules28135129 | 37,446,791 | D014920:Wine; D009812:Odorants; D010447:Peptide Hydrolases; D001546:Bentonite; D006358:Hot Temperature; D008401:Gas Chromatography-Mass Spectrometry; D010450:Endopeptidases; D052617:Solid Phase Microextraction; D055549:Volatile Organic Compounds | Molecules (Basel, Switzerland) | 2,023 | D010447:Peptide Hydrolases; D001546:Bentonite; D010450:Endopeptidases; D055549:Volatile Organic Compounds |
Longitudinal evaluation of cardiovascular function in six healthy cats aged 1-8 years. | OBJECTIVES
The purpose of this study was to determine the impact of ageing on the cardiovascular system of healthy adult cats.
METHODS
Six experimental cats were used. Echocardiography and measurements of systolic blood pressure (SBP) were performed every year for 8 years (from 1 year of age to 8 years of age) in all... | 10.1177/1098612X20932255 | 32,552,525 | D000818:Animals; D002415:Cats; D003971:Diastole; D004452:Echocardiography; D006352:Heart Ventricles; D013599:Systole; D018487:Ventricular Dysfunction, Left; D016277:Ventricular Function, Left | Journal of feline medicine and surgery | 2,021 |
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