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Association of the transfer coefficient of the lung for carbon monoxide with emphysema progression in male smokers. | A decreased transfer coefficient of the lung for carbon monoxide (K(CO)) is associated with emphysema. We evaluated whether in heavy smokers, baseline K(CO) was associated with the progression of computed tomography (CT)-detected emphysema, and the progression of airflow limitation. Heavy smokers, mean ± sd 41.3 ± 18.7... | 10.1183/09031936.00050711 | 21,565,924 | D002248:Carbon Monoxide; D018450:Disease Progression; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung; D008297:Male; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity; D011656:Pulmonary Emphysema; D012907:Smoking; D013147:Spirometry; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity | The European respiratory journal | 2,011 | D002248:Carbon Monoxide |
Hidden symmetry in chains of biological coupled oscillators. | We experimentally investigated spatiotemporal patterns in chains of coupled biological oscillators with boundaries and found hidden symmetric patterns that are not straightforwardly derived from explicit geometrical symmetry of the systems. We propose a model of coupled oscillators in chains with a hidden oscillator in... | 10.1103/PhysRevLett.92.228102 | 15,245,261 | D001683:Biological Clocks; D008954:Models, Biological | Physical review letters | 2,004 | |
A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity. | In contrast to T cells that respond to peptides presented by self MHC molecules, alloreactive T cells recognize determinants expressed on nonself MHC molecules. Because current positive selection models suggest that T cell affinity toward a nonself MHC molecule would be lower than that toward a self MHC molecule, we pr... | 9,190,931 | D002999:Clone Cells; D000939:Epitopes; D015234:HLA-A Antigens; D006801:Humans; D007519:Isoantigens; D010455:Peptides; D013602:T-Lymphocytes, Cytotoxic | Journal of immunology (Baltimore, Md. : 1950) | 1,997 | D000939:Epitopes; D015234:HLA-A Antigens; D007519:Isoantigens; D010455:Peptides | |
Immunological Responses to Total Hip Arthroplasty. | The use of total hip arthroplasties (THA) has been continuously rising to meet the demands of the increasingly ageing population. To date, this procedure has been highly successful in relieving pain and restoring the functionality of patients' joints, and has significantly improved their quality of life. However, these... | 10.3390/jfb8030033 | 28,762,999 | Journal of functional biomaterials | 2,017 | ||
Which complement assays and typings are necessary for the diagnosis of complement deficiency in patients with lupus erythematosus? A study of 25 patients. | INTRODUCTION
Deficiencies in components of the classical pathway of complement activation are strong risk factors for lupus erythematosus (LE).Yet, it has not been addressed whether the conventional measurements of the serum hemolytic CH50 activity and antigenic concentrations of C3 and C4 are sufficient to asses a def... | 10.1016/j.clim.2006.08.007 | 16,987,709 | D000328:Adult; D003176:Complement C3; D003181:Complement C4; D015941:Complement Hemolytic Activity Assay; D003165:Complement System Proteins; D005260:Female; D014644:Genetic Variation; D006649:Histocompatibility Antigens; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D008297:Male; D012189:Retrospective Studies | Clinical immunology (Orlando, Fla.) | 2,006 | D003176:Complement C3; D003181:Complement C4; D006649:Histocompatibility Antigens; D003165:Complement System Proteins |
Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. | The mechanisms by which steatosis renders hepatocytes susceptible to damage in non-alcoholic steatohepatitis (NASH) are unclear although fat accumulation is believed to increase hepatocyte susceptibility to inflammatory cytokines and oxidative stress. We therefore investigated the susceptibility of steatotic, hepatocyt... | 10.1002/jcb.21229 | 17,211,854 | D055372:AMP-Activated Protein Kinases; D045744:Cell Line, Tumor; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D006801:Humans; D050356:Lipid Metabolism; D046529:Microscopy, Electron, Transmission; D009097:Multienzyme Complexes; D019301:Oleic Acid; D010084:Oxidation-Reduction; D018384:Oxidative Stress... | Journal of cellular biochemistry | 2,007 | D009097:Multienzyme Complexes; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D019301:Oleic Acid; D020122:tert-Butylhydroperoxide; D013482:Superoxide Dismutase; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases |
Delayed biodegradation of a meniscal screw. | A biodegradable polylactide meniscal screw was removed 32 months after the original meniscal repair. It was then subjected to gel permeation chromatography and was found to have retained 64.7% of its original molecular weight. Although it is obvious that the manufacturers of biodegradable implants have succeeded in pro... | 10.1016/j.arthro.2004.04.018 | 15,243,418 | D020341:Absorbable Implants; D000328:Adult; D001182:Arthroscopy; D001863:Bone Screws; D002357:Cartilage Diseases; D003560:Cysts; D004868:Equipment Failure; D005547:Foreign Bodies; D006801:Humans; D007719:Knee Joint; D008297:Male; D008592:Menisci, Tibial; D008970:Molecular Weight; D011091:Polyesters; D012086:Reoperation... | Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2,004 | D011091:Polyesters; C033616:poly(lactide) |
The national trend in quality of emergency department pain management for long bone fractures. | BACKGROUND
Despite national attention, there is little evidence that the quality of emergency department (ED) pain management is improving.
OBJECTIVES
To compare the quality of ED pain management before and after implementation of the Joint Commission on the Accreditation of Healthcare Organizations' standards in 200... | 10.1197/j.aem.2006.08.015 | 17,192,448 | D000328:Adult; D004636:Emergency Service, Hospital; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D007591:Joint Commission on Accreditation of Healthcare Organizations; D008297:Male; D010146:Pain; D059408:Pain Management; D010147:Pain Measurement; D011787:Quality of Health Care; D012189:Retrospective Studies... | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2,007 | |
Policies for manual removal of placenta at vaginal delivery: variations in timing within Europe. | The length of the third stage of labour is a potential modifiable risk factor for postpartum haemorrhage at vaginal delivery, but there is no definitive evidence that early intervention to remove the placenta manually will prevent postpartum haemorrhage. We report a wide variation between countries in Europe in policie... | 10.1111/j.1471-0528.2008.01996.x | 19,087,083 | D036861:Delivery, Obstetric; D005060:Europe; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D007749:Labor Stage, Third; D018457:Placenta, Retained; D006473:Postpartum Hemorrhage; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D013997:Time Factors | BJOG : an international journal of obstetrics and gynaecology | 2,009 | |
Structural and functional photoacoustic molecular tomography aided by emerging contrast agents. | Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensiv... | 10.1039/c4cs00086b | 24,967,718 | D000818:Animals; D003287:Contrast Media; D017930:Genes, Reporter; D006801:Humans; D061088:Photoacoustic Techniques; D014054:Tomography | Chemical Society reviews | 2,014 | D003287:Contrast Media |
Chick subcutaneous and abdominal adipose tissue depots respond differently in lipolytic and adipogenic activity to α-melanocyte stimulating hormone (α-MSH). | In birds, α-MSH is anorexigenic, but effects on adipose tissue are unknown. Four day-old chicks were intraperitoneally injected with 0 (vehicle), 5, 10, or 50μg of α-MSH and subcutaneous and abdominal adipose tissue collected at 60min for RNA isolation (n=10). Plasma was collected post-euthanasia at 60 and 180min for m... | 10.1016/j.cbpa.2017.04.013 | 28,438,719 | D050153:Abdominal Fat; D050156:Adipogenesis; D000273:Adipose Tissue; D000818:Animals; D002645:Chickens; D004435:Eating; D008066:Lipolysis; D009074:Melanocyte-Stimulating Hormones | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology | 2,017 | D009074:Melanocyte-Stimulating Hormones |
A Flexible 12-Lead/Holter Device with Compression Capabilities for Low-Bandwidth Mobile-ECG Telemedicine Applications. | In recent years, a number of proposals for electrocardiogram (ECG) monitoring based on mobile systems have been delivered. We propose here an STM32F-microcontroller-based ECG mobile system providing both long-term (several weeks) Holter monitoring and 12-lead ECG recording, according to the clinical standard requiremen... | 10.3390/s18113773 | 30,400,587 | D002138:Calibration; D040421:Cell Phone; D004562:Electrocardiography; D004566:Electrodes; D006801:Humans; D020407:Internet; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D000068997:Smartphone; D012984:Software; D017216:Telemedicine | Sensors (Basel, Switzerland) | 2,018 | |
BCO App: tools for generating BioCompute Objects from next-generation sequencing workflows and computations. | The BioCompute Object (BCO) standard is an IEEE standard (IEEE 2791-2020) designed to facilitate the communication of next-generation sequencing data analysis with applications across academia, government agencies, and industry. For example, the Food and Drug Administration (FDA) supports the standard for regulatory su... | 10.12688/f1000research.25902.1 | 33,299,553 | D019295:Computational Biology; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D063731:Mobile Applications; D057188:Workflow | F1000Research | 2,020 | |
Bench-to-bedside review: outcome predictions for critically ill patients in the emergency department. | The escalating number of emergency department (ED) visits, length of stay, and hospital overcrowding have been associated with an increasing number of critically ill patients cared for in the ED. Existing physiologic scoring systems have traditionally been used for outcome prediction, clinical research, quality of care... | 10.1186/cc3518 | 16,137,387 | D018806:APACHE; D000328:Adult; D002648:Child; D016638:Critical Illness; D004636:Emergency Service, Hospital; D006801:Humans; D017063:Outcome Assessment, Health Care; D019095:Point-of-Care Systems; D011379:Prognosis; D018805:Sepsis; D012720:Severity of Illness Index; D016019:Survival Analysis; D015599:Trauma Severity In... | Critical care (London, England) | 2,005 | |
Comparison of fast spin-echo versus conventional spin-echo MRI for evaluating meniscal tears. | OBJECTIVE
We compare sensitivities of conventional spin-echo and fast spin-echo sequences in the evaluation of meniscal tears. Furthermore, we reevaluate the results from prior studies comparing these two sequences to understand why there are differing conclusions regarding the efficacy of fast spin-echo sequences as a... | 10.2214/ajr.184.6.01841740 | 15,908,523 | D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012680:Sensitivity and Specificity; D000070600:Tibial Meniscus Injuries | AJR. American journal of roentgenology | 2,005 | |
Lost in spatial translation - A novel tool to objectively assess spatial disorientation in Alzheimer's disease and frontotemporal dementia. | Spatial disorientation is a prominent feature of early Alzheimer's disease (AD) attributed to degeneration of medial temporal and parietal brain regions, including the retrosplenial cortex (RSC). By contrast, frontotemporal dementia (FTD) syndromes show generally intact spatial orientation at presentation. However, cur... | 25,913,063 | D000368:Aged; D000544:Alzheimer Disease; D016022:Case-Control Studies; D002540:Cerebral Cortex; D003221:Confusion; D005260:Female; D057180:Frontotemporal Dementia; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe; D013028:Spac... | Cortex; a journal devoted to the study of the nervous system and behavior | 2,015 | ||
Effects of HMGB1 on proliferation and apoptosis of human brain glioma CD133 cells. | OBJECTIVE
To understand the effects of HMGB1 recombinant lentivirus vector on proliferation and apoptosis on CD133 cells after transfecting a human glioma cell strain CD133.
METHOD
The CD133 human glioma cell strain cultured in vitro was transfected with HMGB1 lentiviral vector and empty vector, respectively, while C... | 10.4149/bll_2015_091 | 26,350,087 | D017209:Apoptosis; D001932:Brain Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015316:Genetic Therapy; D005822:Genetic Vectors; D005910:Glioma; D024243:HMGB1 Protein; D006801:Humans; D016086:Lentivirus; D011994:Recombinant Proteins; D014162:Transfection | Bratislavske lekarske listy | 2,015 | D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D011994:Recombinant Proteins |
Air pollution attributable postneonatal infant mortality in U.S. metropolitan areas: a risk assessment study. | BACKGROUND
The impact of outdoor air pollution on infant mortality has not been quantified.
METHODS
Based on exposure-response functions from a U.S. cohort study, we assessed the attributable risk of postneonatal infant mortality in 23 U.S. metropolitan areas related to particulate matter <10 microm in diameter (PM10... | 10.1186/1476-069X-3-4 | 15,128,459 | D000393:Air Pollutants; D000397:Air Pollution; D001724:Birth Weight; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D004781:Environmental Exposure; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D012140:Respiratory Tract Diseases; D018570:Risk Assessment; D013398:Sudde... | Environmental health : a global access science source | 2,004 | D000393:Air Pollutants |
Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells. | Transforming growth factor beta 1 (TGF-beta 1), a potential regulator of growth of prostate cancer cells, exerts its effects through interaction with membrane receptors. In the present study, an attempt was made to establish a correlation between TGF-beta 1 sensitivity and TGF-beta receptor expression in three prostate... | 8,548,772 | D001483:Base Sequence; D002455:Cell Division; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms; D018125:Receptors, Transforming Growth Factor beta; D015398:Signal Transduction; D016212:Transforming Growth Factor beta; D014407:Tumo... | Cancer research | 1,996 | D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta | |
Effects of semen processing on the generation of reactive oxygen species and mitochondrial membrane potential of human spermatozoa. | This study was designed to evaluate the effects of semen processing on the generation of intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) in spermatozoa, and to develop reliable indexes for the evaluation of sperm quality during sperm preparation. Swim-up and density gradient centr... | 10.1111/j.1439-0272.2010.01123.x | 21,729,130 | D000328:Adult; D053627:Asthenozoospermia; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D053078:Membrane Potential, Mitochondrial; D011446:Prospective Studies; D017382:Reactive Oxygen Species; D012661:Semen; D055101:Semen Analysis; D013081:Sper... | Andrologia | 2,012 | D017382:Reactive Oxygen Species |
[The use of virtual communities in the support to patients with breast cancer]. | Thinking about virtual communities as a space for interaction and the sharing of experiences, especially among individuals affected by chronic diseases, the scope of this study was to analyze the role and nature of support offered by virtual communities to breast cancer patients. It is a descriptive study with a qualit... | 10.1590/1413-812320182310.14612018 | 30,365,854 | D001943:Breast Neoplasms; D003430:Cross-Sectional Studies; D004644:Emotions; D005260:Female; D006801:Humans; D061108:Social Media; D060756:Social Networking; D012944:Social Support | Ciencia & saude coletiva | 2,018 | |
Dapsone in the treatment of cutaneous leishmaniasis. | Fifty patients with cutaneous leishmaniasis were treated with dapsone (DDS) approximately 2 mg per kilogram body weight per day for 21 days. Forty patients (80%) were declared cured on the basis of clinical and pathologic criteria. Follow-up examination after 6 months revealed no recurrences. No major side effects were... | 10.1111/j.1365-4362.1986.tb03435.x | 3,531,044 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003622:Dapsone; D005260:Female; D006801:Humans; D007896:Leishmaniasis; D008297:Male; D008875:Middle Aged; D011897:Random Allocation | International journal of dermatology | 1,986 | D003622:Dapsone |
The impact of climate change on the soil/moisture regime of Scottish mineral soils. | The likely impact of climate change on the moisture regime of Scottish soils and consequently on agriculture and land use has been addressed using a novel Geographic Information Systems (GIS) approach. Current estimates of changes in summer precipitation by the year 2030 are 0% with an associated uncertainty of +/- 11%... | 10.1016/0269-7491(94)90039-6 | 15,091,767 | Environmental pollution (Barking, Essex : 1987) | 1,994 | ||
Effects of human pancreatic growth hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and somatomedin-C concentrations in normal women throughout the menstrual cycle. | Human pancreatic tumor GH-releasing factor-40 (hpGRF-40) selectively stimulates GH secretion in normal men and in some adults with GH deficiency. To study its effects in women, we administered hpGRF-40 (3.33 micrograms/kg) or an equivalent volume of vehicle as an iv bolus at 0900 h to 10 normal women during the early f... | 10.1210/jcem-59-5-1006 | 6,434,583 | D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D008597:Menstrual Cycle; D010446:Peptide Fragments; D010908:Pituitary Hormones, Anterior; D011388:Prol... | The Journal of clinical endocrinology and metabolism | 1,984 | D010446:Peptide Fragments; D010908:Pituitary Hormones, Anterior; D013002:Somatomedins; C036893:somatotropin releasing factor 40; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone |
Habitat-specific foraging strategies in Australasian gannets. | Knowledge of top predator foraging adaptability is imperative for predicting their biological response to environmental variability. While seabirds have developed highly specialised techniques to locate prey, little is known about intraspecific variation in foraging strategies with many studies deriving information fro... | 10.1242/bio.018085 | 27,305,927 | Biology open | 2,016 | ||
A neocentromere on human chromosome 3 without detectable alpha-satellite DNA forms morphologically normal kinetochores. | A neocentromere at 3q26 was observed in a father and his daughter on a chromosome 3 with deleted centromeric region. No alpha-satellite DNA was detectable at the 3q26 neocentromere, but it was weakly positive with anticentromere (CREST) antibodies. Electron microscopy showed that the neocentromere formed microtubule-as... | 10.1007/s004120050319 | 9,914,367 | D000328:Adult; D000818:Animals; D002503:Centromere; D002675:Child, Preschool; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D004276:DNA, Satellite; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007231:Infant, Newborn; D018386:Kinetochores | Chromosoma | 1,998 | D004276:DNA, Satellite; D005819:Genetic Markers |
In vitro efficacy of amitraz, coumaphos, deltamethrin and lindane against engorged female Rhipicephalus (Boophilus) annulatus and Haemaphysalis bispinosa ticks. | The present study compares the in vitro efficacy of four chemical acaricides, viz. amitraz, coumaphos, deltamethrin and lindane, against Rhipicephalus (Boophilus) annulatus and Haemaphysalis bispinosa ticks based on adult immersion tests. Amitraz, at 350 ppm, elicited 29.2 ± 4.17% mortality against R. (B.) annulatus, 1... | 10.1007/s10493-018-0262-y | 29,737,450 | D056810:Acaricides; D000818:Animals; D003372:Coumaphos; D005260:Female; D001556:Hexachlorocyclohexane; D066298:In Vitro Techniques; D026863:Ixodidae; D009570:Nitriles; D011722:Pyrethrins; D048494:Rhipicephalus; D013045:Species Specificity; D013983:Tick Control; D014052:Toluidines | Experimental & applied acarology | 2,018 | D056810:Acaricides; D009570:Nitriles; D011722:Pyrethrins; D014052:Toluidines; C017180:decamethrin; C014983:amitraz; D001556:Hexachlorocyclohexane; D003372:Coumaphos |
Microinjection of Live Mammalian Cells: A Delivery Method that Provides Added Versatility to the Study of Cellular Function. | Microinjection is a technique that allows for the delivery of a diverse array of compounds and biomolecules into live mammalian cells. As a result, the behavior of injected biomolecules and their resulting effects can be observed in the native environments of mammalian cells in real time. This capability allows for mor... | 10.1007/978-1-4939-8831-0_30 | 30,353,534 | D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D005347:Fibroblasts; D017408:Guidelines as Topic; D051379:Mice; D008845:Microinjections; D061848:Optical Imaging; D019076:Transgenes | Methods in molecular biology (Clifton, N.J.) | 2,019 | |
Seaweed Porphyra yezoensis polysaccharides with different molecular weights inhibit hydroxyapatite damage and osteoblast differentiation of A7R5 cells. | Vascular calcification (VC) is a common pathological manifestation in patients with cardiovascular diseases, leading to high mortality in patients with chronic kidney diseases. The deposition of hydroxyapatite (HAP) crystals on vascular smooth muscle cells leads to cell damage, which promotes osteogenic transformation.... | 10.1039/c9fo01732a | 32,232,300 | D000469:Alkaline Phosphatase; D000818:Animals; D001011:Aorta; D001806:Blood Urea Nitrogen; D002118:Calcium; D002454:Cell Differentiation; D002460:Cell Line; D002470:Cell Survival; D003404:Creatinine; D017886:Durapatite; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; ... | Food & function | 2,020 | D011134:Polysaccharides; D017382:Reactive Oxygen Species; D053495:Osteopontin; D010758:Phosphorus; D017886:Durapatite; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium |
Sexual harassment: an ominous liability for healthcare professionals. | Sexual harassment can arise in virtually any employment setting. Healthcare facilities must be careful to avoid sexual harassment of their employees both by other employees and by the myriad other persons who may come into contact with their employees in the workplace. Much of what makes sexual harassment an actionable... | 10.1002/jhrm.5600190304 | 10,538,433 | D005260:Female; D006268:Health Facilities; D006801:Humans; D016365:Liability, Legal; D008297:Male; D010559:Personnel Management; D019555:Physician-Nurse Relations; D010824:Physicians' Offices; D011209:Power, Psychological; D012308:Risk Management; D017406:Sexual Harassment; D014481:United States; D017132:Workplace | Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management | 1,999 | |
Mesenchymal transcription factor Fkh6 is essential for the development and differentiation of parietal cells. | The role of transcription factor forkhead homologue 6 (Fkh6) gene expressed only in gastrointestinal mesenchymes on the differentiation of gastric epithelia was analyzed by inactivating the gene by targeting disruption. Gastric mucosa exhibited hyperplasias with disordered glandular structures in the absence of gene. M... | 10.1006/bbrc.2001.4247 | 11,162,636 | D000818:Animals; D002454:Cell Differentiation; D003106:Colon; D004268:DNA-Binding Proteins; D004848:Epithelium; D051858:Forkhead Transcription Factors; D005753:Gastric Mucosa; D005822:Genetic Vectors; D006965:Hyperplasia; D007150:Immunohistochemistry; D008648:Mesoderm; D051379:Mice; D018345:Mice, Knockout; D018613:Micr... | Biochemical and biophysical research communications | 2,001 | D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; C099993:Foxl1 protein, mouse; D014157:Transcription Factors; D012260:Ribonucleases |
Synthesis and characterisation of large chlorapatite single-crystals with controlled morphology and surface roughness. | This work describes the synthesis of chlorapatite single crystals using the molten salt method with CaCl(2) as a flux. By manipulating the processing conditions (amount of flux, firing time and temperature, and cooling rates) it is possible to manipulate the crystal morphology from microscopic fibres to large crystals ... | 10.1007/s10856-012-4717-0 | 22,806,077 | D001031:Apatites; D049109:Cell Proliferation; D003460:Crystallization; D006358:Hot Temperature; D006801:Humans; D059630:Mesenchymal Stem Cells; D008855:Microscopy, Electron, Scanning; D033362:Powder Diffraction; D013499:Surface Properties | Journal of materials science. Materials in medicine | 2,012 | D001031:Apatites |
Protective effects of relaxin in ischemia/reperfusion-induced intestinal injury due to splanchnic artery occlusion. | 1. Splanchnic artery occlusion (SAO) followed by reperfusion causes endothelial injury and inflammation which contribute to the pathophysiology of shock. We investigated the effects of relaxin (RLX), known to afford protection against the deleterious effects of cardiac ischemia/reperfusion, given to rats subjected to s... | 10.1038/sj.bjp.0706811 | 16,847,443 | D000818:Animals; D001157:Arterial Occlusive Diseases; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D007413:Intestinal Mucosa; D007422:Intestines; D008315:Malondialdehyde; D009195:Peroxidase; D011065:Poly(ADP-ribose) Polymerases; D051381:Rats; D017208:Rats, Wistar; D012065:Relaxin; D015427:Reperfusio... | British journal of pharmacology | 2,006 | D008315:Malondialdehyde; D012065:Relaxin; D009195:Peroxidase; D013482:Superoxide Dismutase; D011065:Poly(ADP-ribose) Polymerases |
New binuclear Mn(II) and Fe(II) complexes supported by 1,4,8-triazacycloundecane. | Two new binuclear metal complexes supported by 1,4,8-triazacycloundecane (tacud) are reported. [Fe(2)(tacud)(2)(μ-Cl)(2)Cl(2)] (1) and [Mn(2)(tacud)(2)(μ-Cl)(2)Cl(2)] (2) are isomorphs consisting of bis(μ-chloro) bridged metal centers along with terminal chloro groups and tacud ligands. Both compounds 1 and 2 crystalli... | 10.1039/c0dt01379j | 21,321,733 | D000473:Alkanes; D056831:Coordination Complexes; D018360:Crystallography, X-Ray; D007501:Iron; D008280:Magnetics; D008345:Manganese; D008968:Molecular Conformation; D013696:Temperature | Dalton transactions (Cambridge, England : 2003) | 2,011 | D000473:Alkanes; D056831:Coordination Complexes; D008345:Manganese; D007501:Iron; C022884:undecane |
Therapeutic drug monitoring of 5-fluorouracil. | PURPOSE
For over 50 years, 5-FU has played a critical role in the systemic chemotherapy of cancer patients. 5-FU serves as the main backbone of combination chemotherapy for patients with colorectal cancer in both the adjuvant and metastatic disease settings. Herein, we review the current status of 5-FU therapeutic drug... | 10.1007/s00280-016-3054-2 | 27,217,046 | D000964:Antimetabolites, Antineoplastic; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005472:Fluorouracil; D006801:Humans; D009369:Neoplasms | Cancer chemotherapy and pharmacology | 2,016 | D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil |
MicroRNA-181 inhibits the proliferation, drug sensitivity and invasion of human glioma cells by targeting Selenoprotein K (SELK). | Gliomas are aggressive type of brain tumors and cause significant human mortality world over. The frequent relapses, development of drug resistance, the adverse effects of the chemotherapy and dearth of the therapeutic targets form the major hurdles in glioma treatment. Several studies suggest that microRNAs (miRs) are... | 31,737,213 | American journal of translational research | 2,019 | |||
Exponential stabilization of fixed and random time impulsive delay differential system with applications. | In this work, we study the problem of p-th moment global exponential stability for functional differential equations and scalar chaotic delayed equations under random impulsive effects. Meanwhile, the p-th moment global exponential synchronization for the proposed equations is also discussed, whereas the main results a... | 10.3934/mbe.2021121 | 33,892,551 | Mathematical biosciences and engineering : MBE | 2,021 | ||
Implementation evaluation of an Irish secondary-level whole school programme: a qualitative inquiry. | Whole-of-school programmes (WSPs) are recommended to promote physical activity for adolescents. The Active School Flag (ASF) programme for secondary-level schools is one such WSP. Due to the difficulties of incorporating WSPs into the complex school system, there is a risk of poor implementation. The monitoring of unan... | 10.1093/heapro/daac131 | 36,287,522 | D000293:Adolescent; D006801:Humans; D012572:School Health Services; D012574:Schools; D036301:Qualitative Research; D017144:Focus Groups; D015444:Exercise | Health promotion international | 2,022 | |
Evolution of a Communication System by Sensory Exploitation of Startle Behavior. | New communication signals can evolve by sensory exploitation if signaling taps into preexisting sensory biases in receivers [1, 2]. For mate attraction, signals are typically similar to attractive environmental cues like food [3-6], which amplifies their attractiveness to mates, as opposed to aversive stimuli like pred... | 26,687,622 | D000819:Animal Communication; D000818:Animals; D005075:Biological Evolution; D005260:Female; D006135:Gryllidae; D008297:Male; D009474:Neurons; D013216:Reflex, Startle; D012726:Sexual Behavior, Animal | Current biology : CB | 2,015 | ||
Harnessing the liquid-phase exfoliation of graphene using aliphatic compounds: a supramolecular approach. | The technological exploitation of the extraordinary properties of graphene relies on the ability to achieve full control over the production of a high-quality material and its processing by up-scalable approaches in order to fabricate large-area films with single-layer or a few atomic-layer thickness, which might be in... | 10.1002/anie.201402696 | 25,044,532 | Angewandte Chemie (International ed. in English) | 2,014 | ||
Tuning the Friction Characteristics of Gecko-Inspired Polydimethylsiloxane Micropillar Arrays by Embedding Fe₃O₄ and SiO₂ Particles. | In order to improve stiffness of polydimethylsiloxane (PDMS) pillars while maintaining high friction, the effects of embedding Fe3O4 and SiO2 particles on the friction behavior of PDMS micropillars are studied. Both types of added particles increase the stiffness of the PDMS composite, but affect the friction behavior ... | 10.1021/acsami.5b03301 | 26,042,962 | ACS applied materials & interfaces | 2,015 | ||
Determining optimal cardiac preload during resuscitation using measurements of ventricular compliance. | BACKGROUND
While the right ventricular end-diastolic volume index (RVEDVI) has been shown to be a better indicator of preload than cardiac filling pressures, optimal values during resuscitation from trauma are unknown. This study examines right ventricular stiffness as a guide to optimal values of RVEDVI.
METHODS
Pro... | 10.1097/00005373-200104000-00011 | 11,303,161 | D000328:Adult; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D002496:Central Venous Pressure; D002985:Clinical Protocols; D003187:Compliance; D003971:Diastole; D005260:Female; D005440:Fluid Therapy; D015600:Glasgow Coma Scale; D006801:Humans; D015601:Injury Severity Score; D016014:Linear Models; D008297:Mal... | The Journal of trauma | 2,001 | |
Negative urgency and expectancies increase vulnerability to binge eating in bulimia nervosa. | Negative urgency (NU), the tendency to act impulsively when distressed, is associated with binge eating. Women who believe that eating alleviates negative affect are also more likely to binge eat. Thus, it is hypothesized that the individuals with high levels of NU, and who endorse these eating expectancies, will binge... | 10.1080/10640266.2018.1418253 | 29,384,460 | D000293:Adolescent; D000328:Adult; D032763:Behavior Control; D056912:Binge-Eating Disorder; D052018:Bulimia Nervosa; D004644:Emotions; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D011569:Psychiatric Status Rating Scales; D055815:Young Adult | Eating disorders | 2,018 | |
[Design and validation of a satisfaction questionnaire in patients with urolithiasis treated by extracorporeal shock wave lithotripsy (ESWL).] | OBJECTIVES
Studying the psychosocial sphere of patients who undergo any treatment allows to have more information about its repercussion and can help the choice of an appropriate and personalized treatment. Due to the absence of specific instruments at present, the objective is to design and validate a health questionn... | 30,741,650 | D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D010549:Personal Satisfaction; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D052878:Urolithiasis | Archivos espanoles de urologia | 2,019 | ||
PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager. | We report on the development of the PennPET Explorer whole-body imager. Methods: The PennPET Explorer is a multiring system designed with a long axial field of view. The imager is scalable and comprises multiple 22.9-cm-long ring segments, each with 18 detector modules based on a commercial digital silicon photomultipl... | 10.2967/jnumed.119.229997 | 31,227,573 | D000328:Adult; D002138:Calibration; D004867:Equipment Design; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007700:Kinetics; D008875:Middle Aged; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D012825:Silicon; D051598:Whole Body Imaging | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2,020 | D012825:Silicon |
Interdependence of profilin, cation, and nucleotide binding to vertebrate non-muscle actin. | The interaction of profilin and non-muscle beta,gamma-actin prepared from bovine spleen has been investigated under physiologic ionic conditions. Profilin binding to actin decreases the affinity of actin for MgADP and MgATP by about 65- and 13-fold, respectively. Kinetic measurements indicate that profilin binding to a... | 10.1021/bi001520+ | 11,052,670 | D000199:Actins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000818:Animals; D001665:Binding Sites; D002413:Cations, Divalent; D002417:Cattle; D003285:Contractile Proteins; D004985:Ethenoadenosine Triphosphate; D007700:Kinetics; D008274:Magnesium; D008840:Microfilament Proteins; D008956:Models, Chemi... | Biochemistry | 2,000 | D000199:Actins; D002413:Cations, Divalent; D003285:Contractile Proteins; D004985:Ethenoadenosine Triphosphate; D008840:Microfilament Proteins; D051304:Profilins; D020033:Protein Isoforms; C042937:aza-epsilon-ADP; D000244:Adenosine Diphosphate; D014364:Tryptophan; D000255:Adenosine Triphosphate; D008274:Magnesium |
Pulmonary fibrosis of low calcium diet fed guinea pigs induced by the administration of a soluble immune complex. | Feeding animals a low calcium diet leads to lymphangiectasis of peribronchial lymphatic vessels, sometimes followed by overflow of lymphatic fluid into the surrounding tissue. Adding a soluble immune complex (SIC) to the diet, the peculiar diffuse interstitial pneumonia and finally pulmonary fibrosis were noted. Small ... | 10.1016/s0232-1513(81)80063-1 | 7,250,297 | D000818:Animals; D000936:Antigen-Antibody Complex; D002136:Calcium, Dietary; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011658:Pulmonary Fibrosis | Experimental pathology | 1,981 | D000936:Antigen-Antibody Complex; D002136:Calcium, Dietary |
Size-dependent reactivity of rhodium deuteride cluster anions Rh3Dn - (n = 0-3) toward dinitrogen: The prominent role of σ donation. | Nitrogen (N2) fixation is a challenging task for chemists. Adsorption of N2 on transition metal (TM) sites has been identified as a prerequisite for activating the very stable N≡N triple bond in both industrial and biological processes. The importance of π back-donation (filled orbitals of TM → π* orbitals of N2) betwe... | 10.1063/5.0077183 | 35,168,360 | The Journal of chemical physics | 2,022 | ||
Serotype Identification of Human Adenoviruses Associated with Influenza-Like Illnesses in the Philippines from 2006-2012 by Microneutralization and Molecular Techniques. | OBJECTIVES
Human adenoviruses (HAdV) are known to cause a wide range of diseases including acute respiratory infections, conjunctivitis, and acute gastroenteritis. In this study, we aimed to determine the serotypes of HAdV in patients with influenza-like illness (ILI) in the Philippines from 2006-2012 and to describe t... | 10.1016/j.ijid.2022.02.008 | 35,150,916 | D000258:Adenovirus Infections, Human; D000260:Adenoviruses, Human; D002648:Child; D005838:Genotype; D006801:Humans; D007251:Influenza, Human; D010679:Philippines; D010802:Phylogeny; D012141:Respiratory Tract Infections; D065288:Serogroup | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2,022 | |
Signature-peptide approach to detecting proteins in complex mixtures. | The objective of the work presented in this paper was to test the concept that tryptic peptides may be used as analytical surrogates of the protein from which they were derived. Proteins in complex mixtures were digested with trypsin and classes of peptide fragments selected by affinity chromatography, lectin columns w... | 10.1016/s0021-9673(99)00951-6 | 10,722,087 | D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010455:Peptides; D011506:Proteins; D012015:Reference Standards; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014357:Trypsin | Journal of chromatography. A | 2,000 | D010455:Peptides; D011506:Proteins; D014357:Trypsin |
Prayer and forgiveness: Beyond relationship quality and extension to marriage. | The majority of the world population profess religious/spiritual beliefs and prayer is a form of spiritual activity common across numerous religious/spiritual belief systems. Three studies therefore examined the role of prayer in romantic relationships. Study 1 (n = 91) showed that prayer for a dating partner predicted... | 10.1037/fam0000331 | 28,504,520 | D005260:Female; D061347:Forgiveness; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008393:Marriage; D012067:Religion; D012069:Religion and Psychology; D012747:Sexual Partners; D018454:Spouses; D055815:Young Adult | Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) | 2,017 | |
Modulating the Perceived Softness of Real Objects Through Wearable Feel-Through Haptics. | In vision, Augmented Reality (AR) allows the superposition of digital content on real-world visual information, relying on the well-established See-through paradigm. In the haptic domain, a putative Feel-through wearable device should allow to modify the tactile sensation without masking the actual cutaneous perception... | 10.1109/TOH.2023.3271825 | 37,134,036 | IEEE transactions on haptics | 2,023 | ||
[Chronic urogenital sinus expansion in reconstruction of high persistent cloaca]. | OBJECTIVE
To explore the clinical efficacy of the chronic balloon expansion in urethral and vaginal reconstruction for high persistent cloaca.
METHODS
Clinical data of 21 children with high persistent cloaca undergoing chronic balloon expansion technique in Cangzhou Central Hospital and Capital Pediatric Institute fr... | 26,704,003 | D002908:Chronic Disease; D002988:Cloaca; D005260:Female; D006801:Humans; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D014521:Urethra; D014621:Vagina | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | 2,015 | ||
Highly accelerated multi-shot intravoxel incoherent motion diffusion-weighted imaging in brain enabled by parametric POCS-based multiplexed sensitivity encoding. | Recently, intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) has also been demonstrated as an imaging tool for applications in neurological and neurovascular diseases. However, the use of single-shot diffusion-weighted echo-planar imaging for IVIM DWI acquisition leads to suboptimal data quality: for ... | 10.1002/nbm.5063 | 37,871,617 | NMR in biomedicine | 2,023 | ||
[Do We Have to Wait for the Result of the Intraoperative Quick Parathormone Test in Preoperative Localised Sporadic Parathyroid Adenoma?] | BACKGROUND
In the recent years, targeted surgery, especially minimally invasive parathyroidectomy, has become the procedure of choice to treat sporadic primary hyperparathyroidism (pHPT) and is performed after preoperative standardised, accurate and reliable localisation. The intraoperative quick parathyroid hormone (q... | 10.1055/a-0655-7791 | 30,134,495 | D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands; D010281:Parathyroid Hormone; D010282:Parathyroid Neoplasms; D016105:Parathyroidectomy; D012086:Reoperation; D013997:Time Factors | Zentralblatt fur Chirurgie | 2,018 | D010281:Parathyroid Hormone |
Kinetic studies of enzymatic hydrolysis of insoluble cellulose: Derivation of a mechanistic kinetic model. | A comprehensive mechanistic kinetic model for enzymatic hydrolysis of insoluble cellulose has been synthesized by combining models for several key aspects which have been derived independent of each other. The model takes into account the major contributing factors: the nature of the enzyme system, the structure of cel... | 10.1002/bit.260251115 | 18,548,602 | Biotechnology and bioengineering | 1,983 | ||
Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats. | The cholinergic system is involved in cognition and several forms of dementia, including Alzheimer's disease, and nicotine administration has been shown to improve cognitive performance in both humans and rodents. While experiments with humans have shown that nicotine improves the ability to handle an increasing workin... | 10.1016/j.bbr.2006.01.008 | 16,488,025 | D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D003367:Cotinine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006624:Hippocampus; D018782:Maze Learning; D008568:Me... | Behavioural brain research | 2,006 | D018722:Nicotinic Agonists; D009538:Nicotine; D020932:Nerve Growth Factor; D003367:Cotinine |
Favorable effect of cotransfection with TGF-beta and CTLA4Ig of the donor kidney on allograft survival. | BACKGROUND/AIMS
Gene transfer of viral interleukin 10 (vIL-10) or transforming growth factor beta (TGF-beta) successfully prolonged liver and heart graft survival. Here we assessed whether injection of adenovirus (Ad) coding vIL-10 (AdvIL-10) or TGF-beta3 (AdTGF-beta3) prolonged kidney allograft survival. Since we prev... | 10.1159/000077611 | 15,057,025 | D000069594:Abatacept; D000256:Adenoviridae; D000818:Animals; D015870:Gene Expression; D006085:Graft Survival; D006801:Humans; D018796:Immunoconjugates; D016030:Kidney Transplantation; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D014162:Transfection; D016212:Transforming Growth Factor beta | American journal of nephrology | 2,004 | D018796:Immunoconjugates; D016212:Transforming Growth Factor beta; D000069594:Abatacept |
Potassium: weighing the evidence for supplementation. | Changes in potassium levels clearly have hemodynamic significance. In mechanistic terms, they affect the transmembrane potential of vascular smooth muscle cells. They also influence the levels and activity of pressor hormones and of intracellular messengers involved in vasoconstriction. Furthermore, they alter the body... | 10.1080/21548331.1988.11703592 | 3,142,907 | D000818:Animals; D002463:Cell Membrane Permeability; D004231:Diuresis; D005069:Evaluation Studies as Topic; D005527:Food, Fortified; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension; D009131:Muscle, Smooth, Vascular; D011188:Potassium; D014661:Vasoconstriction; D014664:Vasodilation | Hospital practice (Office ed.) | 1,988 | D011188:Potassium |
Pre-performance psychological states and performance in an elite climbing competition. | The purpose of the present study was to assess the relationship between pre-performance psychological states and expert performance in non-traditional sport competition. Nineteen elite male sport climbers (M=24.6, SD=4.0 years of age) completed the Competitive State Anxiety Inventory-2 and the Positive and Negative Aff... | 10.1111/j.1600-0838.2009.00904.x | 19,486,480 | D000328:Adult; D000339:Affect; D001007:Anxiety; D054874:Athletic Performance; D003163:Competitive Behavior; D006801:Humans; D008297:Male; D009051:Mountaineering; D010555:Personality Inventory; D011594:Psychometrics; D012647:Self-Assessment; D012931:Social Environment; D013315:Stress, Psychological; D055815:Young Adult | Scandinavian journal of medicine & science in sports | 2,010 | |
Terbium Ion Doping in Ca3Co4O9: A Step towards High-Performance Thermoelectric Materials. | The potential of thermoelectric materials to generate electricity from the waste heat can play a key role in achieving a global sustainable energy future. In order to proceed in this direction, it is essential to have thermoelectric materials that are environmentally friendly and exhibit high figure of merit, ZT. Oxide... | 10.1038/srep44621 | 28,317,853 | Scientific reports | 2,017 | ||
Synergistic antitumor effect of suberoylanilide hydroxamic acid and cisplatin in osteosarcoma cells. | Cisplatin, as a first-line chemotherapy drug, has been widely applied for therapy of osteosarcoma. However, its application is limited by drug resistance and serious side effects, including nephrotoxicity and ototoxicity. Suberoylanilide hydroxamic acid (SAHA) is a newly developed histone deacetylase (HDAC) inhibitor, ... | 10.3892/ol.2018.9224 | 30,197,679 | Oncology letters | 2,018 | ||
Outcomes of Endoscopic Submucosal Dissection vs Esophagectomy for T1 Esophageal Squamous Cell Carcinoma in a Real-World Cohort. | BACKGROUND & AIMS
Esophagectomy is the standard treatment for early-stage esophageal squamous cell carcinoma (EESCC), but patients who undergo this procedure have high morbidity and mortality. Endoscopic submucosal dissection (ESD) is a less-invasive procedure for treatment of EESCC, but is considered risky because thi... | 10.1016/j.cgh.2018.04.038 | 29,704,682 | D000368:Aged; D002681:China; D000069916:Endoscopic Mucosal Resection; D004938:Esophageal Neoplasms; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D005260:Female; D017048:Health Care Costs; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retr... | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association | 2,019 | |
Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys. | To examine the origin and assembly of glomerular basement membranes (GBMs), affinity purified anti-laminin IgG was directly coupled to horseradish peroxidase (HRP) and intravenously injected into newborn rats. Kidneys were then processed for peroxidase histochemistry and microscopy. Within 1 h after injection, anti-lam... | 10.1083/jcb.100.6.1988 | 3,889,015 | D000818:Animals; D000831:Animals, Newborn; D001485:Basement Membrane; D002196:Capillaries; D004727:Endothelium; D004848:Epithelium; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D007678:Kidney Glomerulus; D007797:Laminin; D008854:Microscopy, Electron; D051381:Rats;... | The Journal of cell biology | 1,985 | D007797:Laminin |
Bacterial Biofilm Components Induce an Enhanced Inflammatory Response Against Metal Wear Particles. | PURPOSE
Aseptic implant loosening is still a feared complication in the field of orthopaedics. Presumably, a chronic inflammatory response is induced by wear particles, which leads to osteoclast generation, bone degradation and hence loosening of the implant. Since it has been demonstrated in the literature that most i... | 10.2147/TCRM.S280042 | 33,324,065 | Therapeutics and clinical risk management | 2,020 | ||
Anhedonia difference between major depressive disorder and bipolar disorder II. | OBJECTIVE
This study aims to explore the difference in anhedonia between Major Depressive Disorder (MDD) and Bipolar Disorder II (BD-II), and attempt to distinguish the two diseases through Snaith-Hamilton Pleasure Scale (SHAPS).
METHODS
A total of 164 drug-free depressive patients (98 MDD patients, 66 BD-II patients... | 10.1186/s12888-021-03548-w | 34,706,699 | D059445:Anhedonia; D001714:Bipolar Disorder; D003865:Depressive Disorder, Major; D006801:Humans; D057181:Pleasure; D012372:ROC Curve | BMC psychiatry | 2,021 | |
COVID-19 annual update: a narrative review. | Three and a half years after the pandemic outbreak, now that WHO has formally declared that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on recent developments in genetic and genomic research on COVID-19, and we give an outlook on state-of-the-art therapeutical approaches, as the ... | 10.1186/s40246-023-00515-2 | 37,488,607 | D006801:Humans; D000086382:COVID-19; D000086402:SARS-CoV-2; D019143:Evolution, Molecular; D055106:Genome-Wide Association Study; D023281:Genomics | Human genomics | 2,023 | |
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression. | Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 subjects from a prospective 10-year study, we identify 26 IM driver genes in diverse pathways including chromatin regulation (ARID1A) a... | 10.1016/j.ccell.2023.10.004 | 37,890,493 | Cancer cell | 2,023 | ||
7 nm/V DC tunability and millivolt scale switching in silicon carrier injection degenerate band edge resonators. | We demonstrate electro-optical tuning of degenerate band edge resonances in Si photonic waveguides for applications including tunable filters, low voltage switches, and modulators. Carrier injection modulation is enabled by introducing periodic Si slabs to electrically connect the resonator to P and N dopants. Measured... | 10.1364/OE.24.023481 | 27,828,411 | Optics express | 2,016 | ||
Diversity synthesis via C-H bond functionalization: concept-guided development of new C-arylation methods for imidazoles. | Herein, we have formulated the concept of systematic derivatization of a structural motif via C-H bond functionalization. This concept may not only serve as a blueprint for new strategies in diversity synthesis but also provide systematic guidance for the identification of unsolved and important synthetic challenges. T... | 10.1021/ja036157j | 12,940,740 | D001555:Benzene Derivatives; D007093:Imidazoles | Journal of the American Chemical Society | 2,003 | D001555:Benzene Derivatives; D007093:Imidazoles; C059194:2-phenylimidazole |
Long-term Concentrations of Nitrogen Dioxide and Mortality: A Meta-analysis of Cohort Studies. | BACKGROUND
Concentrations of outdoor nitrogen dioxide (NO2) have been associated with increased mortality. Hazard ratios (HRs) from cohort studies are used to assess population health impact and burden. We undertook meta-analyses to derive concentration-response functions suitable for such evaluations and assessed thei... | 10.1097/EDE.0000000000000847 | 29,746,370 | D000397:Air Pollution; D015331:Cohort Studies; D004781:Environmental Exposure; D006801:Humans; D009026:Mortality; D009585:Nitrogen Dioxide; D012621:Seasons | Epidemiology (Cambridge, Mass.) | 2,018 | D009585:Nitrogen Dioxide |
Characterization of the human visual V6 complex by functional magnetic resonance imaging. | Magnetoencephalography of a visual area along the human parieto-occipital sulcus suggested that this region represents the human homologue of the monkey visual area V6 complex (visual area V6/visuomotor area V6A) involved in the integration of visual and somatomotor information. We used functional magnetic resonance im... | 10.1046/j.1460-9568.2003.02645.x | 12,786,987 | D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D014793:Visual Cortex | The European journal of neuroscience | 2,003 | |
Predicting transition to the supine sleep position in preterm infants. | The purpose of this secondary analysis was to determine what factors predict the transition of preterm infants to the supine sleep position prior to hospital discharge (N = 286). The supine position reduces the risk of sudden infant death syndrome. Factors found to predict a greater than 1-week transition to the supine... | 10.1097/ANS.0000000000000051 | 25,365,287 | D001724:Birth Weight; D005260:Female; D005544:Forecasting; D005865:Gestational Age; D017408:Guidelines as Topic; D006760:Hospitalization; D006786:Hospitals, Urban; D006801:Humans; D007223:Infant; D007224:Infant Care; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009518:New York; D016684:Prone Posit... | ANS. Advances in nursing science | 2,014 | |
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. | The discoveries of mutations in SNCA were seminal findings that resulted in the knowledge that α-synuclein (αS) is the major component of Parkinson's disease-associated Lewy bodies. Since the pathologic roles of these protein inclusions and SNCA mutations are not completely established, we characterized the aggregation... | 10.1111/jnc.12806 | 24,984,882 | D000682:Amyloid; D002478:Cells, Cultured; D006801:Humans; D009154:Mutation; D010300:Parkinson Disease; D066329:Protein Aggregates; D051844:alpha-Synuclein | Journal of neurochemistry | 2,014 | D000682:Amyloid; D066329:Protein Aggregates; D051844:alpha-Synuclein |
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. | Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting the Wnt co-receptors LRP5/6. Here we show that Krm2 functions independently from Dkks during neural crest (NC) induction in Xenopus. Krm2 is co-expressed with, and regulated by, canonical Wnts... | 10.1242/dev.005942 | 17,978,005 | D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D004625:Embryo, Nonmammalian; D047108:Embryonic Development; D005260:Female; D017930:Genes, Reporter; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008156:Luci... | Development (Cambridge, England) | 2,007 | C555475:LRP6 protein, human; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008565:Membrane Proteins; D011973:Receptors, LDL; D051153:Wnt Proteins; D029867:Xenopus Proteins; C471148:kremen1 protein, Xenopus; C471149:kremen2 protein, Xenopus; D008156:Luciferases |
One-pot hydrothermal synthesis of highly luminescent nitrogen-doped amphoteric carbon dots for bioimaging from Bombyx mori silk - natural proteins. | Nitrogen-doped carbon dots (CDs) have attracted great interest due to their extraordinary properties, especially their enhanced emission efficiency, and thus a facile synthesis of nitrogen-doped CDs with high emission efficiency is critical for practical applications. To improve the emission efficiency of CDs, herein w... | 10.1039/c3tb20418a | 32,260,873 | Journal of materials chemistry. B | 2,013 | ||
Case Series: Pneumorrhachis Secondary to Spontaneous Pneumomediastinum. | BACKGROUND
Pneumorrhachis (PR) describes the clinical finding of air within the spinal canal and rarely has been associated with spontaneous pneumomediastinum. There is little medical literature addressing the evaluation and management of these patients in the emergency department.
CASE REPORT
We present a series of ... | 26,589,562 | D000328:Adult; D003371:Cough; D006801:Humans; D008297:Male; D008478:Mediastinal Emphysema; D063205:Pneumorrhachis; D014057:Tomography, X-Ray Computed; D055815:Young Adult | The Journal of emergency medicine | 2,016 | ||
Mercury emissions to the atmosphere from anthropogenic sources in Europe in 2000 and their scenarios until 2020. | The paper reviews the current state of knowledge regarding European emissions of mercury and presents estimates of European emissions of mercury to the atmosphere from anthropogenic sources for the year 2000. This information was then used as a basis for Hg emission scenario development until the year 2020. Combustion ... | 10.1016/j.scitotenv.2006.06.023 | 16,887,169 | D000393:Air Pollutants; D003247:Conservation of Natural Resources; D017753:Ecosystem; D004784:Environmental Monitoring; D005060:Europe; D005544:Forecasting; D007220:Industrial Waste; D008628:Mercury | The Science of the total environment | 2,006 | D000393:Air Pollutants; D007220:Industrial Waste; D008628:Mercury |
Repeated forms, testing intervals, and SDMT performance in a large multiple sclerosis dataset. | BACKGROUND
The Symbol Digit Modalities Test (SDMT), the most reliable and sensitive measure of cognition in people with multiple sclerosis (PwMS), is increasingly used in clinical trials and care.
OBJECTIVES
We aimed to establish how SDMT performance is influenced by repeating forms and frequency of use in PwMS.
ME... | 10.1016/j.msard.2022.104375 | 36,544,304 | D006801:Humans; D009103:Multiple Sclerosis; D012189:Retrospective Studies; D003072:Cognition Disorders; D003071:Cognition; D009483:Neuropsychological Tests | Multiple sclerosis and related disorders | 2,022 | |
Multifractals embedded in short time series: An unbiased estimation of probability moment. | An exact estimation of probability moments is the base for several essential concepts, such as the multifractals, the Tsallis entropy, and the transfer entropy. By means of approximation theory we propose a new method called factorial-moment-based estimation of probability moments. Theoretical prediction and computatio... | 10.1103/PhysRevE.94.062201 | 28,085,321 | Physical review. E | 2,016 | ||
Equine tracheobronchial lavage: comparison of lavage cytologic and pulmonary histopathologic findings. | Differential cell counts were done on bronchial lavage specimens from 166 horses. Postmortem gross and histologic examinations were done to determine the pathologic diagnosis of the lungs from these horses. Ninety-two (55%) were normal, 18 (11%) had interstitial pneumonia, 13 (8%) had bronchopneumonia, 13 (8%) had foca... | 3,970,417 | D000818:Animals; D001980:Bronchi; D002452:Cell Count; D006734:Horse Diseases; D006736:Horses; D008168:Lung; D012140:Respiratory Tract Diseases; D013183:Sputum; D013396:Suction; D007507:Therapeutic Irrigation; D014132:Trachea | American journal of veterinary research | 1,985 | ||
Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. | We demonstrated in a previous study that murine double minute (Mdm)-2 is essential for exercise-induced skeletal muscle angiogenesis. In the current study, we investigated the mechanisms that regulate Mdm2 activity in response to acute exercise and identified VEGF-A as a key stimulator of Mdm2 phosphorylation on Ser(16... | 10.1096/fj.15-276964 | 26,578,686 | D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D042783:Endothelial Cells; D005260:Female; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D006801:Humans; D007093:Imidazoles; D008297:Male; D051379:Mice; D018485:Muscle Fibers, Skeletal; D018482:Muscle, Skeletal; D010766:Phosphorylation;... | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2,016 | D051858:Forkhead Transcription Factors; D007093:Imidazoles; D010879:Piperazines; D042461:Vascular Endothelial Growth Factor A; D012694:Serine; C482205:nutlin 3; D051736:Proto-Oncogene Proteins c-mdm2 |
[Extract of Serenoa repens in the treatment of benign prostatic hyperplasia and lower urinary tract symptoms]. | This literature review focuses on the use of Serenoa repens extracts in the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Extracts of Serenoa repens produce marked anti-inflammatory, anti-androgenic and antiproliferative effects. Various extracts differ in their activity depen... | 29,901,305 | D006801:Humans; D008297:Male; D010936:Plant Extracts; D011470:Prostatic Hyperplasia; D028024:Serenoa; D014570:Urologic Diseases | Urologiia (Moscow, Russia : 1999) | 2,018 | D010936:Plant Extracts; C040972:saw palmetto extract | |
Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. | BACKGROUND
This study aimed to evaluate initial hyperleukocytosis and neutrophilia as prognostic indicators in patients with nasopharyngeal carcinoma.
METHODS
A retrospective analysis of 5,854 patients identified from a cohort of 6,035 patients diagnosed with nasopharyngeal carcinoma was performed with initial hyperl... | 10.1371/journal.pone.0136752 | 26,336,064 | D000328:Adult; D002277:Carcinoma; D005260:Female; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms; D009367:Neoplasm Staging; D009504:Neutrophils; D011379:Prognosis; D016016:Proportional Hazards Models; D... | PloS one | 2,015 | |
Volumetric changes in the transferred flap after anterior craniofacial reconstruction. | The goal of craniofacial reconstruction is not only life-saving but also facial aesthetics. From this viewpoint the authors evaluated the facial symmetry of patients after craniofacial reconstruction. The subjects were seven patients reconstructed after craniofacial resections. Their CT or MR images were evaluated just... | 10.1055/s-2006-951313 | 17,048,130 | D000293:Adolescent; D000328:Adult; D002648:Child; D035262:Cranial Fossa, Anterior; D005147:Facial Bones; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012886:Skull; D019292:Skull Ba... | Journal of reconstructive microsurgery | 2,006 | |
A novel method for cross-species gene expression analysis. | BACKGROUND
Analysis of gene expression from different species is a powerful way to identify evolutionarily conserved transcriptional responses. However, due to evolutionary events such as gene duplication, there is no one-to-one correspondence between genes from different species which makes comparison of their express... | 10.1186/1471-2105-14-70 | 23,444,967 | D000818:Animals; D003627:Data Interpretation, Statistical; D004967:Estrogens; D019143:Evolution, Molecular; D005399:Fishes; D020869:Gene Expression Profiling; D018869:Heat-Shock Response; D014158:Transcription, Genetic | BMC bioinformatics | 2,013 | D004967:Estrogens |
Pregnancy outcomes in systemic lupus erythematosus (SLE) women. | Background Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory condition with multi-organ involvement predominantly affecting young women. There are very limited studies in pregnancy in Asian SLE patients and therefore we embarked on this study to identify pregnancy outcomes of Malaysian women with ... | 31,553,696 | D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic; D008181:Lupus Nephritis; D011225:Pre-Eclampsia; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012189:Retrospective Studies | Hormone molecular biology and clinical investigation | 2,019 | ||
Neuromorphic Engineering: From Biological to Spike-Based Hardware Nervous Systems. | The human brain is a sophisticated, high-performance biocomputer that processes multiple complex tasks in parallel with high efficiency and remarkably low power consumption. Scientists have long been pursuing an artificial intelligence (AI) that can rival the human brain. Spiking neural networks based on neuromorphic c... | 10.1002/adma.202003610 | 33,165,986 | D004738:Engineering; D006801:Humans; D016571:Neural Networks, Computer; D009474:Neurons | Advanced materials (Deerfield Beach, Fla.) | 2,020 | |
Self-reported flushing and genotypes of ALDH2, ADH2, and ADH3 among Taiwanese Han. | The aims of this study are to investigate whether self-reported facial flushing postalcohol consumption (PAC) among subjects with ALDH2*1/*1 can be attributed to ADH2 or ADH3 and whether the prediction of ALDH2 genotype can be improved by examining the combination of flushing and other accompanying reactions of PAC sen... | 9,726,271 | D000328:Adult; D000368:Aged; D000426:Alcohol Dehydrogenase; D000428:Alcohol Drinking; D000437:Alcoholism; D016022:Case-Control Studies; D000431:Ethanol; D005006:Ethnicity; D005260:Female; D005483:Flushing; D015971:Gene Expression Regulation, Enzymologic; D005838:Genotype; D006801:Humans; D007527:Isoenzymes; D008297:Mal... | Alcoholism, clinical and experimental research | 1,998 | D007527:Isoenzymes; D000431:Ethanol; D000426:Alcohol Dehydrogenase | |
Indocyanine green video angiography in patients with age-related maculopathy-related retinal pigment epithelial detachments. | Previous studies have stressed the benefit of laser photocoagulation for patients with age-related macular degeneration (AMD) and well-defined subretinal neovascularization (SRN). However, such lesions account for only 30% of cases with exudative age-related maculopathy. Especially in patients with retinal pigment epit... | 7,528,587 | D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011446:Prospective Studies; D012163:Retina... | German journal of ophthalmology | 1,994 | D007208:Indocyanine Green | |
Comparative Outcomes of Primary Gingivoperiosteoplasty and Secondary Alveolar Bone Grafting in Patients with Unilateral Cleft Lip and Palate. | BACKGROUND
The role of primary gingivoperiosteoplasty in the repair of alveolar clefts remains controversial. The aim of this study was to compare the outcomes of primary gingivoperiosteoplasty and secondary alveolar bone grafting in patients with unilateral cleft lip and palate.
METHODS
In this prospective study, th... | 10.1097/PRS.0000000000001897 | 26,710,026 | D064728:Alveolar Bone Grafting; D016009:Chi-Square Distribution; D002675:Child, Preschool; D002971:Cleft Lip; D002972:Cleft Palate; D015331:Cohort Studies; D054893:Cone-Beam Computed Tomography; D005260:Female; D005500:Follow-Up Studies; D005893:Gingivoplasty; D006801:Humans; D007223:Infant; D008297:Male; D010521:Perio... | Plastic and reconstructive surgery | 2,016 | |
Associations between race, discrimination and risk for chronic disease in a population-based sample from Canada. | A major epidemiological finding emerging from studies using U.S. samples is that racial differences in experiences of discrimination are associated with racial differences in health. A newer area of research is exploring the population-level dynamics between race, discrimination, and health status in various societies.... | 10.1016/j.socscimed.2017.10.009 | 29,100,138 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada; D002908:Chronic Disease; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012306:Risk; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires | Social science & medicine (1982) | 2,017 | |
Accuracy of orthognathic surgery with customized titanium plates-Systematic review. | This systematic review aimed to evaluate the accuracy of customized titanium plates in orthognathic surgery compared to standard outcome in virtual surgical planning. PRISMA and JBI guidelines were followed. Research protocol was registered in PROSPERO. Six databases and two gray literature repositories were used as so... | 10.1016/j.jormas.2020.06.011 | 32,622,000 | D001860:Bone Plates; D006801:Humans; D057909:Orthognathic Surgery; D056948:Orthognathic Surgical Procedures; D014025:Titanium | Journal of stomatology, oral and maxillofacial surgery | 2,021 | D014025:Titanium |
Effect of Modified Peristaltic Phacoemulsification Device on Efficiency and Post-Occlusion Pressure Surge. | Purpose
To evaluate efficiency of grooving, nuclear fragment removal, and changes in pressure control in the Oertli Faros using traditional peristaltic and Speed and Precision (SPEEP) features. The SPEEP mode uses novel peristaltic technology permitting independent control of flow and vacuum.
Methods
A porcine lens m... | 10.2147/OPTH.S416604 | 37,600,145 | Clinical ophthalmology (Auckland, N.Z.) | 2,023 | ||
Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels. | BACKGROUND/AIMS
Arctigenin possesses biological activities, but its underlying mechanisms at the cellular and ion channel levels are not completely understood. Therefore, the present study was designed to identify the anti-arrhythmia effect of arctigenin in vivo, as well as its cellular targets and mechanisms.
METHOD... | 10.1159/000354532 | 24,280,730 | D000157:Aconitine; D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac; D020746:Calcium Channels, L-Type; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005663:Furans; D007473:Ion Channels; D017705:Lignans; D008297:Male; D0... | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2,013 | D000889:Anti-Arrhythmia Agents; D020746:Calcium Channels, L-Type; D005663:Furans; D007473:Ion Channels; D017705:Lignans; D015221:Potassium Channels; D015222:Sodium Channels; C071942:arctigenin; D000157:Aconitine |
Effect of nonlinear summation of synaptic currents on the input-output properties of spinal motoneurons. | A single spinal motoneuron receives tens of thousands of synapses. The neurotransmitters released by many of these synapses act on iontotropic receptors and alter the driving potential of neighboring synapses. This interaction introduces an intrinsic nonlinearity in motoneuron input-output properties where the response... | 10.1152/jn.00439.2005 | 16,079,193 | D000818:Animals; D002415:Cats; D003198:Computer Simulation; D004056:Differential Threshold; D019706:Excitatory Postsynaptic Potentials; D008564:Membrane Potentials; D008959:Models, Neurological; D009046:Motor Neurons; D009433:Neural Inhibition; D017711:Nonlinear Dynamics; D013116:Spinal Cord; D013569:Synapses; D009435:... | Journal of neurophysiology | 2,005 | |
In vivo analysis of a superantigen-induced T cell suppressor factor. | We have previously reported that the superantigen staphylococcal enterotoxin B (SEB) was able to suppress an immune response to sheep red blood cells when administered intravenously to mice. While the capacity of the superantigens to stimulate lymphocytes and accessory cell functions has been thoroughly examined, it is... | 10.1006/cimm.1996.0037 | 8,603,438 | D000818:Animals; D000917:Antibody Formation; D004768:Enterotoxins; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018089:Superantigens; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regula... | Cellular immunology | 1,996 | D004768:Enterotoxins; D018089:Superantigens; D013491:Suppressor Factors, Immunologic; C031818:enterotoxin B, staphylococcal |
Factors that preclude the successful use of monopharmacy in the medical treatment of patients with epilepsy. | A neurologist conducted research efforts for more than 12 years as a step toward the establishment of monotherapy for epilepsy. Of 406 patients with epilepsy, seizures could be controlled for more than one year in 72% and for more than 3 years in 54%. Monotherapy was given to 57% of all the patients with a success rate... | 10.1111/j.1440-1819.1990.tb01405.x | 2,124,285 | D000328:Adult; D000927:Anticonvulsants; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial; D004827:Epilepsy; D004833:Epilepsy, Temporal Lobe; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male | The Japanese journal of psychiatry and neurology | 1,990 | D000927:Anticonvulsants |
Observations from a 'special selective drive' conducted under National Leprosy Elimination Programme in Karjat taluka and Gadchiroli district of Maharashtra. | The special selective drive (SSD) was conducted on a request from the Joint Director of Health Services (Leprosy and TB) Government of Maharashtra. The study team comprised the Foundation for Medical Research (FMR), assisted by a member of the Acworth Leprosy Hospital Society for Research, Rehabilitation and Education ... | 20,704,074 | D003150:Community Health Workers; D057210:Delayed Diagnosis; D005260:Female; D006266:Health Education; D007722:Health Knowledge, Attitudes, Practice; D006297:Health Services Accessibility; D006801:Humans; D007194:India; D007918:Leprosy; D008297:Male; D011320:Primary Health Care; D012424:Rural Population | Indian journal of leprosy | 2,009 | ||
The parageneses thermodynamic analysis of chemoautotrophic CO2 fixation archaic cycle components, their stability and self-organization in hydrothermal systems. | The parageneses physico-chemical analysis based on a method of thermodynamic potentials has been used to study the system of C-H-O organic compounds, which are, in particular, components of biomimetically built primordial cycles of carbon dioxide chemoautotrophic fixation. Thermodynamic data for aqueous organic compoun... | 10.1016/j.jtbi.2008.11.032 | 19,168,083 | D001105:Archaea; D002245:Carbon Dioxide; D002627:Chemistry, Physical; D052837:Chemoautotrophic Growth; D017753:Ecosystem; D008954:Models, Biological; D009792:Oceans and Seas; D010084:Oxidation-Reduction; D013696:Temperature; D013816:Thermodynamics; D018707:Volcanic Eruptions | Journal of theoretical biology | 2,009 | D002245:Carbon Dioxide |
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