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anorectal melanomas comprise approximately 1% of all melanomas and about 0.52% of all anorectal malignancies . common presentations for anorectal melanoma include rectal bleeding , anorectal pain , change in bowel habits or a rectal mass . therefore , given the lack of pathognomonic clinical complaints , early diag...
primary malignant melanoma of the anus and rectum is a rare and aggressive neoplasm that tends to invade locally and metastasize early in the course of the disease . it is often misdiagnosed as hemorrhoids or as one of the other benign anorectal conditions and is thus linked to an overall poor prognosis and a 5-year ...
general accounting office , 1991a ; iglehart , 1991a , 1991b , 1988a , 1988b ) , financing and cost - containment mechanisms ( u.s . general accounting office , 1991b ) , and levels of health care spending ( schieber , poullier , and greenwald , 1991 ) . however , little has been written about the comparative diffe...
international systems are frequently offered as models for health care reform . this study , focusing on preventive services for children and pregnant women in six industrialized countries , finds that a broad range of preventive services can be provided through health care systems with divergent financing and cost c...
microsurgery remains the gold standard for the treatment of intraventricular tumors [ 14 ] , but microsurgical approaches are not without limitations [ 512 ] . the desire for a less invasive but equally effective surgical approach to intraventricular pathology has directed the attention of many in the neurosurgical c...
introduction . though traditional microsurgical techniques are the gold standard for intraventricular tumor resection , the morbidity and invasiveness of microsurgical approaches to the ventricular system have galvanized interest in neuroendoscopic resection . we present a systematic review of the literature to provi...
one of the widely accepted techniques for restoring pit and fissure caries and prevention of caries development in adjacent pit and fissures is preventive resin restoration ( prr ) [ 14 ] . in this technique , decayed tooth tissue is replaced with composite resins and at the same time , intact pit and fissures are se...
objective : this study addresses the question of whether conservative methods of restoration may be applied efficaciously in permanent posterior teeth with proximal lesions and intact occlusal preventive resin restoration ( prr ) . the purpose of the present study was to assess the microleakage at amalgam - composite...
the introduction of the immunomodulatory drug lenalidomide has revolutionized the treatment of patients with myelodysplastic syndromes ( mds ) and deletion of the long arm of chromosome 5 . treatment with lenalidomide results in transfusion independence in the majority of patients , but some questions remain unresolv...
backgroundthe introduction of the immunomodulatory drug lenalidomide has revolutionized the treatment of patients with myelodysplastic syndromes ( mds ) and deletion of the long arm of chromosome 5 . treatment with lenalidomide results in transfusion independence in the majority of patients , but some questions remai...
post traumatic hip dislocations are very rare in children . neglected anterior hip dislocations in children are not described in literature so far . here , we present a case of 6 weeks old anterior hip dislocation successfully managed by open reduction . a 9-year - old male child presented with neglected anterior hip...
introduction : post traumatic hip dislocations are very rare in children . neglected anterior hip dislocations in children are not described in literature so far . here , we present a case of 6 weeks old anterior hip dislocation successfully managed by open reduction.case presentation : a 9-year - old male child presen...
a 55-year - old man with a 28-year history of diabetes was referred to our retina clinic for a regular ophthalmic examination for diabetic retinopathy . at the time of the first visit , the patient presented with proliferative diabetic retinopathy in both eyes and clinically significant macular edema . he had undergo...
a 60-year - old diabetic patient transferred to our retina clinic for a regular follow - up for diabetic retinopathy . he had uneventful cataract surgery at the time of pars plana vitrectomy in the right eye due to diabetic retinopathy at a private ophthalmologic hospital . six months after the surgery , neovascula...
chronic myelomonocytic leukemia ( cmml ) is a clonal hematopoietic stem cell neoplasm with overlapping myelodysplastic and myeloproliferative features . while progression to acute myeloid leukemia ( aml ) is common , the driving molecular aberrations involved in transformation remain obscure . clonal cytogenetic abno...
we have identified a novel 7.7 mb del(8)(q23.2q24.11 ) in a patient progressing to acute myeloid leukemia ( aml ) following a 12-year stable phase of chronic myelomonocytic leukemia ( cmml ) . a surprisingly high jak2 + allelic burden of 92% at the time of aml led us to delineate the molecular aberrations relevant for...
one - third of patients with epilepsy have seizures that are resistant to pharmacological therapy . resective surgery is effective for patients with pharmacoresistant epilepsy who have a localized area of epileptogenic tissue in noneloquent cortex . these masses of disorganized neuronal tissue are usually associate...
a 19-year - old man with cortical dysplasia and intractable focal seizures underwent a right temporal lobectomy . a hypothalamic hamartoma was subsequently recognized , and he then underwent mri - guided stereotactic laser ablation . unfortunately , he sustained damage to the bilateral medial mammillary bodies and ...
eosinophilic gastroenteritis is an uncommon disease that 's pathologically characterized by marked eosinophilic infiltration in any area of the gastrointestinal tract without the presence of parasitic infections , drug reactions or malignancy . since it was first described in 1937 by kaijer1 ) , approximately 300 cases...
eosinophilic gastroenteritis is defined as a disorder that selectively affects the gastrointestinal tract with eosinophil - rich inflammation in the absence of any known causes for eosinophilia . the clinical manifestations vary according to the site of the eosinophilic infiltrated layer of the bowel wall . eosinop...
leptospirosis is a bacterial zoonosis with global distribution , although it has been documented in developing and developed as well as temperate and tropical countries [ 1 , 2 ] . this disease occurs predominantly as a subclinical infection although cases of clinical disease with numerous nonpathognomonic signs and ...
the study compared the serological evidence of leptospirosis in 212 students in four schools ( veterinary , dental , advanced nursing education and pharmacy ) of the university of the west indies ( uwi ) , by testing for igg immunoglobulins to leptospira spp . using the enzyme - linked immunosorbent assay ( elisa ) and...
laparoscopic surgery of the prepared upper and lower gastrointestinal ( gi ) tract has been well reported . successful closure of ruptured duodenal ulcers associated with peritoneal soiling has demonstrated that laparoscopic techniques can be applied to repair of the perforated viscus . more controversial is the th...
elective laparoscopic colonic surgery is increasingly recognized as feasible and perhaps preferential . a case of laparoscopically assisted surgery for trauma to the rectum with bacterial peritonitis is presented . it presents an example of the application of this modality to the treatment of iatrogenic colon perfo...
staphylococcus aureus is a gram - positive bacterium , a ubiquitous pathogen that constitutes one of the major causes of infections in humans . the most consistently identified ecological niche for s. aureus in humans is in the anterior nares and up to one third of healthy people carry this organism in the nose at an...
summarywe present a basic mathematical model of staphylococcus aureus transmission in the usa based on natural history of infection and nationally representative data . we employed a susceptible - colonized - infected - recovered - susceptible compartmental modelling framework with two different phenotypes of s. aure...
increased interest in an esthetic facial appearance has led to an increase in the number of adult orthodontic patients . many patients underwent previous dental restorations to treat wear , attrition , missing teeth , and malformed teeth.1 distinct surface treatments are required to increase the bond strength between...
objectivethe aim of this study was to compare the shear bond strength ( sbs ) of orthodontic brackets bonded to zirconia surfaces using three different zirconia primers and one silane primer , and subjected to thermocycling.methodswe designed 10 experimental groups following the surface treatment and thermocycling . ...
of these newly diagnosed breast tumors , 6570% will express the estrogen receptor alpha ( er ) . estrogen activation of the er is required in the development of a healthy mammary gland . however , it also can be involved in the development of both primary and secondary breast cancers due to altered er signaling [ 3...
fulvestrant ( ici 182,780 ; ici ) is approved for the treatment of advanced metastatic breast cancer that is unresponsive to other endocrine therapies . berries are frequently consumed for their antioxidant , anti - inflammatory , and anticancer potential . in this study , we tested the efficacy of two berry extracts...
nowadays , insertion of an expandable metallic stent ( ems ) is the standard treatment to rescue obstructive jaundice caused by unresectable pancreaticobiliary malignancies . as one of the problematic complications of biliary ems , stent migration occurs in 1.8 - 8.3% of cases with covered biliary ems and in 0 - 2.4%...
metallic stent migration is a well - known complication which can not always be managed by removal or repositioning , especially in case of uncovered stent . we report a patient who developed obstructive jaundice due to migration of an expandable metallic stent ( ems ) inserted in the lower bile duct . trimming of ...
breast cancer is a malignancy arising from the epithelial tissues that line the terminal ductal - lobular units of the breast [ 1 , 2 ] . breast cancer ( bc ) is the most common cancer in females worldwide ; bc is the leading cause of cancer death among females , with an estimated 1.7 million cases and 521,900 deaths i...
epigenetic modifications are involved in breast carcinogenesis . identifying genes that are epigenetically silenced via methylation could select target patients for diagnostic as well as therapeutic potential . we assessed promoter methylation of breast cancer susceptibility gene 1 ( brca1 ) and 17 beta hydroxyster...
coronary artery disease ( cad ) including myocardial infarction ( mi ) is a leading cause of death worldwide [ 1 , 2 ] . the well - known conventional coronary risk factors include age , male sex , hypertension , diabetes mellitus , hypercholesterolemia , smoking and family history , which have been repeatedly demons...
coronary artery disease ( cad ) is a multifactorial disease with environmental and genetic determinants . the genetic determinants of cad have previously been explored by the candidate gene approach . recently , the data from the international hapmap project and the development of dense genotyping chips have enable...
vitamins are essential for nutrition and physiological function , and therefore , their intake is necessary for humans and animals , as the body is unable to synthesize these essential nutrients required for growth . vitamins can be classified into water - soluble and fat - soluble vitamins ; the former includes niac...
a novel and simple method for detecting six water - soluble vitamins in animal feed using high performance liquid chromatography equipped with a photodiode array detector ( hplc / pda ) and ion - pairing reagent was developed . the chromatographic peaks of the six water - soluble vitamins were successfully identified...
acute acalculous cholecystitis ( aac ) is a well - recognized but still poorly understood entity . it is well - known to occur in very sick patients already admitted in intensive care unit ( icu ) , e.g. , after major trauma , burns , sepsis , major non - biliary surgery and after parenteral feeding , with high incid...
aim : this study is aimed to evaluate the role of cholescintigraphy in management of acute acalculous cholecystitis.materials and methods : a total of thirty two patients who had presented to the surgical out - patient department or referred from in - patient department or intensive care unit between february 2008 and ...
the infection by this protozoan is called amoebiasis ; a primary intestinal infection which may be complicated by extra - intestinal infection ( 1 ) . this protozoan organism is the third leading parasitic cause of death in the developing world and is an important health risk to travelers in endemic areas ( 2 ) . a...
amoebic liver abscess is a complication of amoebiasis that needs early diagnosis and proper treatment before further complications occur . we report a-35 year old female presented by fever and dyspnea due to huge liver abscess complicated by massive right side empyema . the patient was effectively treated by percut...
huntington s disease ( hd ) is a devastating inherited neurodegenerative disease caused by an expansion of the cag repeat region in exon 1 of the huntingtin gene . although huntingtin is expressed throughout the body , the polyglutamine expanded protein is especially toxic to medium spiny neurons in the striatum and...
huntington s disease is a devastating , incurable neurodegenerative disease affecting up to 12 per 100,000 patients worldwide . the disease is caused by a mutation in the huntingtin ( htt ) gene . there is interest in reducing mutant huntingtin by targeting it at the mrna level , but the maximum tolerable dose and ...
the prevalence of asthma is approximately 300 million cases in the world and in thailand it affects approximately 6.9% of adults . the airway becomes swollen and inflamed and the muscles around the airway contract causing the bronchial tubes to narrow . symptoms and exacerbations of asthma include breathlessness , ...
introduction . vitamin d deficiency has been linked to an increased risk of asthma exacerbations . objective . this study aimed to compare vitamin d status during the period of severe asthma exacerbations and investigate if vitamin d supplementation improves asthma control . methods . a total of 47 asthmatic pati...
as an undergraduate chemistry major at the university of illinois in urbana - champaign , i did not have a clear idea of what i was going to do after college until i attended a standing - room - only seminar by sol spiegelman on his demonstration of phage q replication in vitro . it was not a difficult decision as a ...
the genetics society of america s thomas hunt morgan medal is awarded to an individual gsa member for lifetime achievement in the field of genetics . the 2014 recipient is frederick ausubel , whose 40-year career has centered on host microbe interactions and host innate immunity . he is widely recognized as a key ...
despite advances in insulin therapy , hypoglycaemia remains a significant concern and limits optimization of insulin dosing to achieve glycaemic targets.1 hypoglycaemia is associated with increased morbidity and cardiovascular risk.1 patients / caregivers may be fearful of nocturnal hypoglycaemia , which may affect sle...
basal insulin peglispro ( bil ) is a novel basal insulin with hepatopreferential action , resulting from reduced peripheral effects . this report summarizes hypoglycaemia data from five bil phase iii studies with insulin glargine as the comparator , including three doubleblind trials . prespecified pooled analyses ( ...
fans of doctor who , the quintessential british science fiction television series , have been able to enjoy the adventures of its main character ( the doctor ) for over three decades . as a time lord from the planet gallifrey , the doctor can regenerate his body completely as he nears death . the doctor s regenerativ...
regeneration of complex structures after injury requires dramatic changes in cellular behavior . regenerating tissues initiate a program that includes diverse processes such as wound healing , cell death , dedifferentiation , and stem ( or progenitor ) cell proliferation ; furthermore , newly regenerated tissues must...
the obesity treatment literature includes many sophisticated analyses , methods , and conclusions , yet the problem persists [ 13 ] . given all of the information now known , to move forward in intervention development and evaluation , more accurate measures of success are needed to monitor changes . the field of obe...
background . measuring success of obesity interventions is critical . several methods measure weight loss outcomes but there is no consensus on best practices . this systematic review evaluates relevant outcomes ( weight loss , bmi , % body fat , and fat mass ) to determine which might be the best indicator(s ) of ...
the presence of an idic(ph ) chromosome(s ) represents a mechanism for genomic bcrabl1 amplification and may contribute to resistance against targeted therapies based on imatinib or dasatinib . a 52yearold , previously healthy man presented to his local ed with worsening right groin pain of 2months duration , which beg...
key clinical messagean isodicentric philadelphia chromosome is an uncommon finding previously described as a secondary chromosomal abnormality in accelerated or blastphase of chronic myeloid leukemia ( cml ) with resistance to imatinib mesylate or dasatinib . here , we present a case with idic(ph ) chromosome identif...
testis tumors are rare , but it is the most common solid tumor in men under 45 years of age . although intracardiac metastases of testicular germ cell tumors occur rarely in clinics , they may lead to the congestive heart failure , paradoxical systemic emboli and vena cava superior syndrome with disseminated involvem...
although intracardiac metastasis of germ cell tumors is rare , it can be localized in the right or left heart by disseminating spread and give their cardiac symptoms depending on the location of metastatic mass . we present a 38-year - old male patient with a preliminary diagnosis of testicular tumor who was followed...
median arcuate ligament syndrome ( mals ) or celiac artery compression syndrome is a rare disorder caused by compression of celiac artery by the median arcuate ligament . clinical symptoms include postprandial abdominal pain , nausea , vomiting , epigastric bruit and weight loss . most of the patients with this syn...
median arcuate ligament syndrome is a rare disorder characterized by chronic postprandial abdominal pain and weight loss caused by compression on celiac artery . a 17-year - old girl with chronic severe abdominal pain and weight loss was referred to our clinic . other causes of chronic abdominal pain were investiga...
hence , compounds that selectively modulate the action as well as the levels of endocannabinoids represent templates for potential new therapeutic strategies . in this sense , the exogenous administration of the endocannabinoid anandamide is known to induce the decrease of blood pressure in spontaneously hypertensive...
in rat isolated mesenteric beds that were contracted with na as an in vitro model of the vascular adrenergic hyperactivity that usually precedes the onset of primary hypertension , the oral administration ( 3 daily doses ) of either 10 mg / kg genistein or 20 mg / kg daidzein potentiated the anandamide - induced redu...
in 1955 , pepys postulated that histamine ( ha ) could affect the immune response . since then , the influence of ha on immune and inflammatory reactions has been well documented . in the late 1970s and early 1980s , watanabe 's , schwartz 's , and panula 's groups in japan , france , and finland , respectively , dem...
neuroimmune dysregulation is a common phenomenon in different forms of central nervous system ( cns ) disorders . cross - links between central and peripheral immune mechanisms appear to be disrupted as reflected by a series of immune markers ( cd3 , cd4 , cd7 , hla - dr , cd25 , cd28 , and cd56 ) which show variabil...
high invasiveness and resistance to therapy are common biological and clinical characteristics of refractory cancer that represent major challenges for research and treatment . the mechanisms involved in tumor invasion include cell motility and migration , degradation of the extracellular matrix and interaction with ...
tumor cell invasion and resistance to therapy are the most intractable biological characteristics of cancer and , therefore , the most challenging for current cancer research and treatment paradigms . refractory cancers , including pancreatic cancer and glioblastoma , show an inextricable association between the high...
obtain frozen mouse embryonic fibroblasts ( mefs ) ( generated previously from individual embryo primary cultures ) from liquid nitrogen . thaw cells by immersing vial in 37c water with swirling until contents are completely thawed . add 9ml of dmem that has been supplemented with 10% fetal bovine serum and 1% peni...
the ability to genetically remove specific components of various cell signalling cascades has been an integral tool in modern signal transduction analysis . one particular method to achieve this conditional deletion is via the use of the cre - loxp system . this method involves flanking the gene of interest with lo...
the concept of endometriosis is based on histological confirmation of ectopic implants of glands and/or endometrial stroma sensitive to hormones but not including those located in the myometrium.123 the pathogenesis of the disease is probably multifactorial . retrograde menstruation is the most widespread theory that...
the widespread use of endoscopic ultrasound has facilitated the evaluation of subepithelial and surrounding lesions of the gastrointestinal tract . deep pelvic endometriosis , with or without infiltration of the intestinal wall , is a frequent disease that can be observed in women in their fertile age . patients of...
splenic artery aneurysms are the most common visceral artery aneurysms ( 1 ) . aberrant origin of splenic artery from the superior mesenteric artery ( sma ) is rare . aneurysms of an aberrant splenic artery are very uncommon with only 25 cases reported in literature ( 2 ) . we describe the imaging findings and the ...
we report a rare case of aneurysm of splenic artery arising anomalously from the superior mesenteric artery ( sma ) . the aneurysm was treated successfully by coil embolization of the splenic artery distal to aneurysm and then deploying a stent graft in the sma . a combination of stent graft and coil embolization f...
congenital heart disease is the most prevalent form of developmental abnormality in newborns , with an estimated prevalence of 1% , and is the leading non - infectious cause of infant mortality , with more than 29% of neonates who die of a birth defect having a cardiovascular deformity . congenital cardiovascular ano...
summarybackgroundventricular septal defect ( vsd ) is the most prevalent type of congenital heart disease and is a major cause of substantial morbidity and mortality in infants . accumulating evidence implicates genetic defects , especially in cardiac transcription factors , in the pathogenesis of vsd . however , vsd...
in vertebrates , dickkopf ( dkk ) family genes encode four secreted proteins ( dkk14 ) and a unique dkk3-related protein , soggy or dkk - like1 ( dkkl1 ) . dkks are potent inhibitors of -catenin stabilization in the wnt signaling pathway and suppress the expression of a variety of canonical wnt/-catenin signaling tar...
dickkopf ( dkk ) family proteins are secreted modulators of the wnt signaling pathway and are capable of regulating the development of many organs and tissues . we previously identified dkk3 to be a molecule predominantly expressed in the mouse embryonic retina . however , which cell expresses dkk3 in the developin...
gastric adenocarcinoma ( gc ) is the fifth most common cancer in the world , with approximately one million new cases and 730,000 deaths occurring annually . in the united states , approximately 21,600 new cases occurred in 2015 . therapeutic advances in gastric cancer have been slow and 5-year survival is less than ...
phosphatidylinositol-3-kinase ( pi3k ) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies . therapeutic targeting of pi3k pathway components has improved outcomes in chronic lymphocytic leukemia , kidney cancer , breast cancer , and neuroendocrine tumors . ...
treatment of limited stage of hodgkin lymphoma by introducing new chemotherapy regimens and combining radiotherapy and chemotherapy has significantly evolved in recent years and failure in treatment is seen only in 10 to 20% of patients . recently , there are tangible improvements in advanced stages of hodgkin lympho...
abstractbackground : despite multiple published studies reporting result of salvage regimens for relapsed and refractory hodgkin 's lymphoma , there are no comparisons of different combinations.patients and methods : a total of 44 patients identified with refractory or relapsed hodgkin 's lymphoma were considered eligi...
medication is central to treating and managing type ii diabetes mellitus , a prevalent age - related chronic illness . effective treatment is often undermined by nonadherence , with as many as half of patients not taking medications as prescribed [ 2 , 3 ] . nonadherence is traced to many causes but often involves ...
among patients with various levels of health literacy , the effects of collaborative , patient - provider , medication - planning tools on outcomes relevant to self - management are uncertain . objective . among adult patients with type ii diabetes mellitus , we tested the effectiveness of a medication - planning tool ...
deep sternal wound infection ( dswi ) is a severe and life - threatening complication of median sternotomy after cardiac surgery , with an incidence ranging from 1% to 3% and a mortality rate ranging from 19% to 29% . this complication is associated with prolonged hospital stay , augmented surgical load due to repe...
backgroundthis study aimed to investigate the influence of deep sternal wound infection on long - term survival following cardiac surgery.material/methodsin our institutional database we retrospectively evaluated medical records of 4732 adult patients who received open - heart surgery from january 1995 through december...
haemolytic uraemic syndrome ( hus ) is a thrombotic microangiopathy characterized by coombs - negative haemolytic anaemia , thrombocytopenia and microvascular thrombosis , with many patients also experiencing acute renal failure . approximately 90% of cases have typical hus , which is secondary to infection by a shig...
atypical haemolytic uraemic syndrome ( ahus ) is a rare and life - threatening disease caused by complement system dysregulation leading to uncontrolled complement activation and thrombotic microangiopathy . we report the case of an adult patient with plasmaphaeresis - resistant ahus and hypertension treated with the...
the arctic and antarctic regions are rich and diverse ecosystems for birds , fish , and mammals . this in turn means that there is a risk that migratory birds ( and other animals ) can bring pathogens or resistant bacteria into animal populations in the arctic and antarctic environments ( 42 ) . whether the introdu...
anthropogenic influences in the southern polar region have been rare , but lately microorganisms associated with humans have reached antarctica , possibly from military bases , fishing boats , scientific expeditions , and/or ship - borne tourism . studies of seawater in areas of human intervention and proximal to fre...
fishes are the largest group of vertebrates , with a wide variety of adaptive responses to diversified aquatic habitats and ecological limitations . also with respect to sex determination , unlike the situation in most vertebrates , where the male and female sexes are represented by two different individuals ( gonoch...
parodontidae fish show few morphological characteristics for the identification of their representatives and chromosomal analyses have provided reliable features for determining the interrelationships in this family . in this study , the chromosomes of apareiodon hasemani from the so francisco river basin , brazil , ...
actually ugtb is not rare disease but it is often overlooked disease . the main reasons for delayed diagnostic are two : vague clinical features and low index of suspicion . ugtb is an infectious contagious disease , and it is one of the most reasons for infertility .
tuberculosis is a disease with myriad presentations and manifestations ; it can affect any organ or tissue , excluding only hair and nails . doctors who are not familiar with extrapulmonary tuberculosis often overlook this disease . urogenital tuberculosis ( ugtb ) is the second most common form of tb in countries ...
traditionally , patients with liver cirrhosis have an auto - anticoagulation status because they often have an elevated prothrombin time ( pt ) or international normalized ratio ( inr ) [ 14 ] . however , the accumulated evidence suggests that cirrhotic patients have an increased risk of venous thromboembolism ( vte ...
backgroundrisk of venous thromboembolism ( vte ) , including deep vein thrombosis ( dvt ) and pulmonary embolism ( pe ) , may be increased in liver cirrhosis . we conducted a single - center study to explore the epidemiology , risk factors , and in - hospital mortality of vte in chinese patients with liver cirrhosis....
infertility is an important health problem , with an estimated prevalence of 48.5 million couples worldwide ( 1 ) . although infertility is mostly common in aging populations and in urban areas where women have their first child at an older age , the burden of infertility and its social consequences are predominantly...
introductionthis study illustrated the global contribution to assisted reproductive technologies ( arts ) research in medline database from 1998 to 2014.methodsin march 2015 , the medline database was searched for research publications indexed under reproductive techniques , assisted ( including the following mesh hea...
mesenchymal stem cells ( mscs ) are one of the most interesting types of adult stem cells that are isolated , cultured , manipulated ex vivo , and have the ability of self - renewal and differentiation into various mesodermal cell lineages ( 1 - 3 ) . since the first description of mscs by friedenstein et al in 1976 as...
objective(s):immunosuppressive property of mesenchymal stem cells ( mscs ) has great attraction in regenerative medicine especially when dealing with tissue damage involving immune reactions . the most attractive tissue sources of mscs used in clinical applications are bone marrow ( bm ) , adipose tissue ( at ) , and...
when attempting to measure potential health benefits , a number of methods are available including cost benefit analysis , cost - effectiveness analysis , and cost - of - illness analysis . the selection of an appropriate method should be consistent with the available data and the phenomenon being studied . benefi...
background increased consumption of foods containing plant sterols has the potential to reduce the incidence of coronary heart disease ( chd ) and thus reduce costs associated with treating that disease in a significant way . this paper reports the results of an investigation of the potential monetary benefits of all...
although glaucoma is primarily a disease of the ganglion cells , the retinal nerve fiber layer ( rnfl ) is the most commonly imaged layer of the retina in the evaluation of glaucoma patients . even before the widespread use of imaging technologies , rnfl evaluation has always been an important part of the clinical exam...
purpose . to show how peripapillary spectral domain optical coherence tomography ( sdoct ) retinal thickness ( rt ) maps can complement retinal nerve fiber layer ( rnfl ) thickness maps in the evaluation of glaucoma patients . methods . after a complete eye exam with standard fundus photography and visual field testi...
vitamin d is a fat - soluble secosteroid prohormone ingested in the diet and produced in the skin following exposure to ultraviolet rays in sunlight , and conversion to active forms of vitamin d occurs in the liver and kidneys.1 the metabolic processes regulated by vitamin d include serum calcium and phosphate homeosta...
backgroundthe purpose of this cross - sectional study was to test the hypothesis that serum vitamin d levels are abnormally low in sleep clinic patients admitting to chronic nonspecific musculoskeletal pain and to assess the associated risk factors . a secondary purpose was to identify a clinical biomarker for vitami...
in 2011 , the prevalence in the us of end - stage renal disease ( esrd ) was 507,326 , and there were 88,931 deaths attributable to esrd.1 medicare costs for esrd were $ 34.3 billion in 2011 , accounting for over 6% of the total medicare budget . on january 1 , 2011 , medicare enacted an esrd bundled prospective paymen...
backgroundferric citrate is a novel phosphate binder which has the potential to reduce usage of erythropoietin - stimulating agents ( esas ) and intravenous ( iv ) iron used for anemia management during hemodialysis ( hd ) among patients with end - stage renal disease ( esrd ) . currently , the potential health care ...
psychogenic polydipsia ( ppd ) , a clinical disorder characterized by polyuria and polydipsia , is defined by hyponatremia found in 10 - 20% of those presenting with compulsive drinking . symptoms are not typically seen until the patient reaches their limit of maximal urine dilution ( 100 mosmol / kg with minimum uri...
psychogenic polydipsia , in its most severe form , can lead to acute water intoxication by way of extreme hyponatremia . this results in cerebral edema , mental status deterioration and can lead to life threatening intracranial hypertension if not identified and treated urgently . however , this treatment rarely in...
the increase in demand for poultry meat and eggs has necessitated the establishment of new farms and slaughter houses away from their original places of production , and consequently , a considerable increase in poultry transportation arises [ 1 , 2 ] . results obtained from an increasing body of research have convinci...
the modulating effects of ascorbic acid ( aa ) , vitamin e ( e ) , and a combination of aa and e ( aa + e ) against eight - hour road transportation stress were investigated in 120 pullets during the hot - dry season . the result obtained showed that handling , loading and transportation induced lymphopenia , neutrop...
photobiomodulation uses lowpower , highfluence light from lasers or leds in the red to nearinfrared range ( 6201,100 nm ) to modulate mitochondrial respiration in a nondestructive and nonthermal manner 1 , 2 . transcranial laser stimulation of the brain with nearinfrared light is a novel form of photobiomodulation ,...
background and objectivetranscranial laser stimulation of the brain with nearinfrared light is a novel form of noninvasive photobiomodulation or lowlevel laser therapy ( lllt ) that has shown therapeutic potential in a variety of neurological and psychological conditions . understanding of its neurophysiological effe...
lentiviral vectors are promising gene transfer agents for ex vivo correction of inherited or acquired genetic defects . hematopoietic disorders are well suited as targets for this approach , due to the relative ease with which these cells are harvested , transduced ex vivo with lentivirus , and reinfused into patient...
the p140k point mutant of mgmt allows robust hematopoietic stem cell ( hsc ) enrichment in vivo . thus , dual - gene vectors that couple mgmt and therapeutic gene expression have allowed enrichment of gene - corrected hscs in animal models . however , expression levels from dual - gene vectors are often reduced for o...
currently , approximately ten million people have chagas disease worldwide , with the disease burden being centered in latin america . sleeping sickness is another serious health problem , particularly in sub - saharan countries ; in the first half of the twentieth century , this disease practically decimated entire ...
approximately ten million people suffer from chagas disease worldwide , caused by trypanosoma cruzi , with the disease burden predominately focused in latin america . sleeping sickness is another serious health problem , caused by trypanosoma brucei , especially in sub - saharan countries . unfortunately , the drug...
this 34-year - old man had progressive visual loss in the left eye of 2 months . automated visual fields were symmetrically normal . after seeking a second opinion 14 days later , best - corrected visual acuity ( bcva ) of the left eye was 20/100 ( 6/30 ) with diffuse disc elevation and peripapillary nerve fiber hemo...
we present a healthy male subject who developed progressive visual loss in the left eye initially diagnosed as optic neuritis . upon suspicion of infectious etiology , testing was positive for tuberculosis . there were no signs or symptoms of active systemic tuberculosis infection . the patient responded swiftly to...
dental caries remains today the most common infectious disease which affects most of the population regardless of age . caries prevalence is high , and oral hygiene is not good , in poor and developing countries as well as albania . several studies have noted that children with disabilities have higher levels of ca...
introduction : this study was carried out at nine ( 9 ) special schools for disabled children in albania . the aim of the study is to determine the caries prevalence and oral hygiene status of children with different disabilities attending different schools for disabled at albania.methods:participants are grouped acc...
a 46-year - old caucasian man presented with a 10-year history of mild gait ataxia and undirected vertigo after fast head movements . he had a past medical history of resection of a thyroid adenoma and also for benign polyposis of the sigmoid colon . at the age of 41 years physical inspection revealed megalocephaly...
lhermitte - duclos disease ( ldd ; dysplastic cerebellar gangliocytoma ) is a rare hamartomatous lesion of the cerebellar cortex and this was first described in 1920 . ldd is considered to be part of the autosomal - dominant phacomatosis and cancer syndrome cowden disease ( cs ) . we examined the brain of a 46-year...
central nervous system ( cns ) involvement is a rare complication of acute promyelocytic leukemia ( apl ) and is encountered more frequently at the relapse stage than at presentation . the cns is the most commonly affected site of extramedullary relapse in apl [ 1 , 2 ] . the incidence of cns relapse ranges between...
central nervous system ( cns ) involvement in acute promyelocytic leukemia ( apl ) is rare , and the presence of cns symptoms at the time of diagnosis of apl is even rarer . we report 2 cases of apl presenting with cns involvement . a 43-yr - old woman presented with easy bruising and stuporous mentality . her comp...
members of the genus trichophyton are the most common agents of dermatophytosis in humans and other animals , and are associated with a variety of clinical aspects ( 1 - 3 ) . the most frequent species of dermatophytes are trichophyton mentagrophytes , t. tonsurans , and t. rubrum , and these species cause a multip...
background : the high degree of phenotypic similarity among trichophyton species makes their identification difficult.objectives:the current study aims to establish the use of rolling circle amplification ( rca ) based on internal transcribed spacer ribosomal dna ( its rdna ) as a powerful , simple , and rapid procedur...
the appearance of multiple malignancies in the same patient is a rare occurrence , which can either be synchronous or metachronous . the incidence of multiple malignancies varies with age , sex , geographic origin , and site and type of tumors . the etiology is multifactorial , and some of the factors involved in t...
multiple malignancies may occur in the same patient , and a few reports describe cases with multiple hematologic and non - hematologic neoplasms . we report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung . a 62-year -...
saprolegnia parasitica is a fish pathogenic oomycete ( water mould ) , belonging to the saprolegniales order and known to infect a wide range of fish , amphibians , and crustaceans relevant to aquaculture and to aquatic ecosystems ( van west et al . it causes saprolegniosis , a disease characterised by visible white ...
here we describe the first application of transient gene silencing in saprolegnia parasitica , a pathogenic oomycete that infects a wide range of fish , amphibians , and crustaceans . a gene encoding a putative tyrosinase from s. parasitica , sptyr , was selected to investigate the suitability of rna - interference ...
acute pancreatitis ( ap ) is characterized by an inflammatory affection of the exocrine pancreatic tissue and disturbances of pancreatic microcirculation.1 depending on the severity of ap , irreversible perfusion failure with consecutive tissue hypoxia and necrosis can complicate the course of the disease and trigger s...
acute pancreatitis ( ap ) is characterized by disturbances of pancreatic microcirculation . it remains unclear whether platelets contribute to these perfusion disturbances . the aim of our study was to investigate platelet activation and function in experimental ap . acute pancreatitis was induced in rats : ( 1 )...
dichelobacter nodosus is a gram - negative anaerobic bacterium and the main causative organism of ovine foot rot . foot rot is a contagious and crippling disease affecting the feet of sheep , characterized by a range of symptoms depending on severity , from a nonprogressive interdigital dermatitis ( in benign foot ro...
ovine foot rot is an infection of the feet of sheep , mainly caused by dichelobacter nodosus . in its virulent form , it is highly contagious and debilitating , causing significant losses in the form of decline in wool growth and quality and poor fertility . current methods of treatment are ineffective in complete ...
the most outstanding feature of cells is that they produce a large amount of insulin , the only hormone that lowers blood glucose , and secrete it continuously in response to changes in the extracellular glucose concentration . insulin secretion from pancreatic cells also is modified by a variety of nutrients , hormo...
abstractnewly generated insulinsecreting cells for use in cell therapy for insulindeficient diabetes mellitus require properties similar to those of native pancreatic cells . pancreatic cells are highly specialized cells that produce a large amount of insulin , and secrete insulin in a regulated manner in response to...
in the last decade , the use of 3d image processing has been increased especially for medical applications ; this leads to increase the qualified radiologists ' number who navigate , view , analyse , segment , and interpret medical images . the analysis and visualization of the image stack received from the acquisiti...
the experimental study presented in this paper is aimed at the development of an automatic image segmentation system for classifying region of interest ( roi ) in medical images which are obtained from different medical scanners such as pet , ct , or mri . multiresolution analysis ( mra ) using wavelet , ridgelet , a...
duck virus hepatitis ( dvh ) is one of the most economic import diseases to all duck - growing farms because of its high potential mortality if the infection is not controlled . the morbidity is 100% and the mortality may reach 95100% , in the first week of age . survived ducklings after dhv infection have a solid ...
the present study aimed to investigate the protective effect of glycyrrhizin ( locally isolated and purified from licorice root ) against duck hepatitis virus through the assessment of some hematological and biochemical parameters . one hundred and sixty white pekin ducklings one day old were randomly divided into...
since 2011 , pneumonia has overtaken cerebrovascular disorders as the third leading cause of death in japan . elderly people are particularly prone to developing severe pneumonia because of various underlying conditions ( 1 ) . nutritional support plays an integral role in the treatment of critically ill patients a...
for nutritional support of critically ill patients , the enteral route is preferred over the parenteral route . although nasojejunal feeding can be superior to gastric feeding when gastrointestinal symptoms occur , it does not necessarily solve the problem of large gastric residual volumes . we report the successfu...
over the past decades , considerable advances have been made in the use of long - course crt in rectal cancer . based on a number of pivotal studies in the us which demonstrated positive effects on local control ( lc ) and overall survival ( os ) with the addition of rt and chemotherapy following surgical resection i...
the addition of 5-fluorouracil ( 5-fu ) or its prodrug capecitabine to radiotherapy ( rt ) is a standard approach in the neo - adjuvant treatment of patients with rectal tumors extending beyond the muscularis propria ( stage ii ) and/or with clinical evidence of regional lymph node metastases ( stage iii ) . according ...
the short - wave near - infrared ( sw - nir ) region , 7001100 nm , is suitable for nondestructive or noninvasive analysis of biological and biomedical materials [ 13 ] . compared with long - wave nir region ( 11002526 nm ) , the short - wave near - infrared can penetrate more deeply into a sample with less heating...
a multichannel short - wave near - infrared ( sw - nir ) spectrometer module based on charge - coupled device ( ccd ) detection was designed . the design relied on a tungsten lamp enhanced by light emitting diodes , a fixed grating monochromator and a linear ccd array . the main advantages were high optical resolut...
charcot spinal arthropathy ( csa ) is a rare , progressive vertebral joint degeneration that occurs in the setting of any preexisting condition characterized by decreased afferent innervation severe enough to impair the normal protective sensation of joints of the vertebral column1 ) . historically , csa occurs most ...
charcot spinal arthropathy is a rare , progressive type of vertebral joint degeneration that occurs in the setting of any preexisting condition characterized by decreased afferent innervation to the extent that normal protective joint sensation in the vertebral column is impaired . the authors report on a case of cha...
according to the world health organization ( who ) , approximately 5% of the world population or 365 million people has either moderate or severe hearing loss of either congenital or acquired etiology . in korea , some 300,000 people are believed to have some hearing loss , which is the second highest of 15 disabilit...
this brief communication introduced a systematic way to find a professional audiology clinic developed for patients and professionals by the american academy of audiology , american speech - language - hearing association , and healthy hearing . patients can access each organization 's website to find professionals a...
therefore , the first and the most important strategy to confront this is the comprehensive implementation of tobacco control programs . however , this implementation can not be easily achieved because tobacco companies try their best to seek new customers for their products and replace those who quit smoking or died o...
background : a report of the activities of countries worldwide for six main policies to control tobacco use is published once every 2 years by the world health organization ( who ) . our objective was to perform a quantitative analysis for it in countries and regions to make a simple view of its programs.methods:this...
apart from use in operative cases and cardiac laboratories , transesophageal echocardiography ( tee ) in now being increasingly used in critical care units . the complications with its use are primarily related to gastrointestinal , cardiovascular , and respiratory systems along with some miscellaneous problems related...
the use of transesophageal echocardiography ( tee ) has been increasing over the past few years . it is considered a semi - invasive monitor and a safe diagnostic device . though complications are rare , they must be known to operators who frequently perform tee . tee probes are known to cause tissue heating and ...
influenza , an infectious respiratory disease caused by influenza viruses , is one of the main causes of excess winter deaths ( ewds ) in europe [ 1 - 3 ] . annual flu epidemics are associated with high morbidity and mortality rates , especially among the elderly and those with underlying health conditions ; these gr...
summaryinfluenza , an infectious respiratory disease , is one of the main causes of excess winter deaths ( ewds ) in europe . annual flu epidemics are associated with high morbidity and mortality rates , especially among the elderly , those with underlying health conditions and pregnant women.health care workers ( hc...
functionalized , nitrogen - containing heterocycles constitute a widespread structural motif in biologically active compounds(1 ) and an invaluable template for chiral auxiliaries(2 ) in asymmetric synthesis.(3 ) in particular , tetrahydroisoquinolines ( thiqs ) and indoles are common structural motifs in important com...
a highly facile , straightforward synthesis of 1-(3-indolyl)-tetrahydroisoquinolines was developed using either simple copper or iron catalysts . n - protected and unprotected tetrahydroisoquinolines ( thiq ) could be used as starting materials . extension of the substrate scope of the pronucleophile from indoles t...
asthma is a chronic inflammatory disease of the airways affecting over 300 million people worldwide , and its prevalence is rising , especially in children and within developing countries . new studies indicated that in allergic disorders , including asthma , innate immunity is deregulated by allergens that promote s...
this study aimed at exploring innate and adaptive immunity in allergic asthma by investigation of mrna expression of pattern recognition receptors , t - cell - specific cytokines , and transcription factors . mouse models for mild and severe asthma , with similar pathological characteristics observed in humans , were...
to report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma ( lsc ) and increase people s awareness of the disease . a 58-year - old male patient was diagnosed with lsc ; however , after the end of the second course of chemotherapy , his white blood cells increased ...
purposeto report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma ( lsc ) and increase people s awareness of the disease.patients and methodsa 58-year - old male patient was diagnosed with lsc ; however , after the end of the second course of chemotherapy , his white...
the age of smoking onset is decreasing in both developed and developing countries and most of the developed countries have implemented several policies in order to reduce smoking rates , more specifically among adolescents . this is because the age at initiation of cigarette smoking is one of the important determinan...
background : notwithstanding the importance of smoking stages evaluation in adolescents , there is not an appropriate instrument for its measurement . this study aims to introduce an appropriate instrument for measurement of smoking stages in adolescents and to examine its validity using latent class analysis ( lca ) m...
coracoid fractures can be missed and the treatment for coracoid process fractures is still controversial . the case presented here is of an isolated coracoid process fracture which was treated surgically . a 15-years old male presented after 4 days of injury complaining of persistent pain in the right shoulder follow...
introduction : isolated coracoid fractures are rare and few scattered cases are reported in literature . coracoid fractures can be missed and the treatment for coracoid process fractures is still controversial . the case presented here is of an isolated coracoid process fracture which was treated surgically.case repo...
trabeculectomy remains the surgery of choice in patients with advanced glaucomatous optic neuropathy ( gon ) . in conventional trabeculectomy , efforts have been made to improve the outcomes and reduce the complications of trabeculectomy . in this regard , the ex - press glaucoma implant was introduced as a nonvalv...
we describe an innovative technique for performing standardized low cost glaucoma filtration surgery using a polytetrafluoroethylene ( ptfe ) intravenous cannula . the trocar of a 24 gauge ( 24 g ) ptfe intravenous cannula was used to create a trabeculectomy ostium and its tube was inserted under a partial thickness ...
periodontal disease may present a wide variation of its appearance , which brings lack of uniformity on the criteria that define its aspects . conventional dental radiography , widely employed as a tool to determine the situation ( presence and extension ) of periodontal disease , is considered adequate to surveys of...
the reproducibility of measurements of alveolar bone loss on radiographs may be a problem on epidemiologic studies , as they are based on comparisons of the diagnosis of various examiners . the aim of the present research paper was to assess the inter- and intra - examiner reproducibility of measurements of the inter...
since it has been introduced by yasargil in the 1970s11 ) , the pterional or the fronto - temporo - sphenoidal approach has been widely used to approach lesions of the sellar or suprasellar region , circle of willis and sylvian fissure . although the standard pterional approach has been accepted as a safe and appropria...
objectivethe lateral supraorbital ( lso ) approach is a modified method of the classic pterional approach and it has advantages of short skin incision and small craniotomy compared with the pterional approach . this study was designed to compare the two approaches in the surgical treatment of unruptured intracranial ...
the finding of a renal mass on imaging is suggestive of metastatic non - small cell lung cancer in the presence of a lung tumor but can also have another origin . we describe the case of a patient diagnosed with stage iv lung cancer based on a renal metastasis . a second opinion including review of histopathological ...
backgroundthe finding of a renal mass on imaging is suggestive of metastatic non - small cell lung cancer in the presence of a lung tumor but can also have another origin.case reportwe describe the case of a patient diagnosed with stage iv lung cancer based on a renal metastasis . a second opinion including review of...
different etiologies for cystic lesions in the lumbar spinal canal have been reported in the literature , among them hemorrhagic cysts , perineural cysts , dermoid cysts , and parasitic cysts . the most common lesion seems to originate from the facet joints : the synovial cyst , which represents a protrusion of the s...
degenerative changes in the lumbar spine can be followed by cystic changes . most reported intraspinal cysts are ganglion or synovial cysts . ligamentum flavum pseudocyst , as a cystic lesion in the lumbar spine , is a rare and unusual cause of neurologic signs and symptoms and is usually seen in elderly persons ( ...
the relationship between autism and imitation deficits was envisaged long time ago by ritvo and province , short after autism was originally described in the work of kanner . the imitative ability has been acknowledged to play an essential role in normal development , as it can be used by infants to acquire and maste...
it has been suggested that children with autism are particularly deficient at imitating novel gestures or gestures without goals . in the present study , we asked high - functioning autistic children and age - matched typically developing children to imitate several types of gestures that could be either already known ...
the den2-s2 virus used in the primary screen was isolated via serial passage of den2-ngc ( a gift from dr . a. de silva unc - ch ) in d.mel-2 cells ( invitrogen ) . the experimental schedule for the primary and secondary screens is outlined in fig . the human screen was done with huh-7 cells treated independently ...
dengue fever ( df ) is the most frequent arthropod - borne viral disease of humans , with almost half of the world 's population at risk of infection1 . the high prevalence , lack of an effective vaccine , and absence of specific treatment conspire to make df a global public health threat1 , 2 . given their compact...
standing from a seated position and walking are basic components of many daily activities and have been analyzed using various methods . the sit - to - walk ( stw ) task involves the sequential motions occurring from standing to initiating gait . magnan1 and kerr2 , 3 examined the stw task using a three - dim...
[ purpose ] the purpose of this study was to clarify the validity of accelerometer data for quantifying fluidity during the sit - to - walk task . [ subjects ] the participants were 16 healthy young males . [ methods ] the timing of events ( task onset , maximum trunk inclination , and first heel strike ) was d...
gangliocytic paragangliomas ( gps ) are rare and peculiar benign tumors , encountered mostly in the periampullary area of the duodenum and much less frequently in the jejunum or third part of the duodenum . some studies have reported that approximately 90% of gps are found in the second part of the duodenum , from ...
gangliocytic paragangliomas ( gps ) are rare tumors of the duodenum , presenting as single sessile or pedunculated polypoid masses . clinical manifestations of duodenal gps can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdominal pain . ...
block copolymers self - assemble on the 10100 nm length scale and are attractive materials to structure direct inorganic components into materials with mesoscale features . one route to such materials involves the use of block copolymers as sacrificial templates . this strategy involves selective degradat...
selective degradation of block copolymer templates and backfilling the open mesopores is an effective strategy for the synthesis of nanostructured hybrid and inorganic materials . incorporation of more than one type of inorganic material in orthogonal ways enables the synthesis of multicomponent nanomateria...
in the previous issue of critical care , kushimoto and colleagues reported on the clinical usefulness of transpulmonary thermodilution - derived extravascular lung water ( evlw ) and the pulmonary vascular permeability index ( pvpi ) in the diagnosis of acute respiratory distress syndrome ( ards ) . in an observation...
the recent berlin definition has made some improvements in the older definition of acute respiratory distress syndrome ( ards ) , although the concepts and components of the definition remained largely unchanged . in an effort to improve both predictive and face validity , the berlin panel has examined a number of ad...
amino acid substitution is known as an important strategy to detect , and to analyze key residues in the structural and functional properties of proteins , and in the protein - ligand interactions ( yang et al . , 1997 ; chiaoto et al . , 2007 ; bogan and thorn , 1998 ; lo conte et al . it has also been used in a n...
technical strategies like amino acid substitution and residue modification have been widely used to characterize the importance of key amino acids and the role that each residue plays in the structural and functional properties of protein molecules . however , there is no systematic approach to assess the impact of the...
adaptive radiation requires organismal evolvability , ecological opportunities , and diversifying selection which create new niches in terms of physical space and new interactions between organisms and environment or allow empty ones to be colonised by adaptive lineages [ 14 ] . this process is directly relevant to t...
adaptive radiation in bacteria has been investigated using wrinkly spreaders ( ws ) , a morphotype which colonises the air - liquid ( a - l ) interface of static microcosms by biofilm formation with a significant fitness advantage over competitors growing lower down in the o2-limited liquid column . here , we investi...
the age - standardized incidence is approximately 1 per 100,000 women in the united states and few cases have been reported since 1957.2- 4 hcc is aggressive during pregnancy and has a poor prognosis with an overall one - year survival of 23% , which could be explained by two main etiologies : estrogen elevation whic...
hepatocellular carcinoma ( hcc ) is very rare during pregnancy and has a worse prognosis in pregnant women compared to those who are not pregnant . we present a case of hcc in a 41- year - old pregnant patient who was referred to our academic hospital.the patient presented with chief complaints of abdominal pain , ja...
systemic lupus erythematosus ( sle ) is an autoimmune disease that may involve multiple organs . herein , we report a case of fatal gastrointestinal vasculitis as a rare presentation of systemic lupus erythematosus in a 34-year - old woman . a 34-year - old woman was admitted to our hospital because of progressive ...
this case report demonstrates fatal gastrointestinal vasculitis as a rare presentation of systemic lupus erythematosus . a 34-year - old woman presented with abdominal pain and diarrhea . anti nuclear antibody was positive and high titre of anti - ds dna antibody was also reported . treatment with corticosteroid an...
primary tumors of the trachea are rare , occurring in less than 2 out of 1,000,000 persons per year representing less than 0.1% of cancer death . adenoid cystic carcinoma ( acc ) is the second most common primary malignant tracheal neoplasm after squamous cell carcinoma . acc commonly arises at the distal portion o...
primary malignant tracheal tumors are not common and adenoid cystic carcinoma ( acc ) of trachea is rare . we report an extremely rare case of acc of proximal trachea , which was diagnosed in a 42-year - old male who presents with 6-month history of dyspnea . lateral skiagram of neck , computed tomography , and magne...
cases evaluated in this study were selected from patients who underwent biopsies during a 12-month period . two hundred ninety three female patients with 314 lesions underwent us - guided biopsies at a single facility . the mean patient age was 39.9 years with a range of 17 - 81 years . the vast majority of the m...
objectivethis study aims to evaluate the degree of inter- and intraobserver agreement when characterizing breast abnormalities using the breast imaging reporting and data system ( bi - rads)-ultrasound ( us ) lexicon , as defined by the american college of radiology ( acr).materials and methodstwo hundred ninety three ...