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there is evidence corroborating the relationship of vascular dysfunction during the first decade of life with risk factors such as familial hypercholesterolemia and hypertension .
however , the question whether or not people exposed to cigarette smoke also develop these dysfunctions remains controversial .
numerous... | objectivemany diseases form their basis during childhood .
one example is the changes in vascular structure and function , leading to atherosclerosis . in this study , we have assessed the impact of exposure to cigarette smoke on blood pressure of elementary school children in kermanshah.methods80 elementary school c... |
the present analysis was performed as part of the diabetes and informatics ( dai ) study , a multicenter cohort study conducted by the dai study group ( diainf ) together with the italian association of clinical diabetologists ( amd ) and the italian national institute of health ( iss ) since september 1998 .
the aim... | objective the purpose of this study was to assess incidence of and risk factors for recurrent cardiovascular disease ( cvd ) in type 2 diabetes.research design and methods we estimated the incidence of recurrent cardiovascular events in type 2 diabetic patients , aged 4097 years , followed by a network of diabetes cl... |
electrophysiological brain signals are widely studied to get insights into the inner function of the brain .
the electro - encephalogram ( eeg ) , as an example , has been analyzed for decades and is particularly popular because of its noninvasiveness , wide availability , relatively small cost and excellent temporal... | electrophysiological signals such as the eeg , meg , or lfps have been extensively studied over the last decades , and elaborate signal processing algorithms have been developed for their analysis .
many of these methods are based on time - frequency decomposition to account for the signals ' spectral properties whil... |
written informed consent was obtained from the patient for publication of this case report and accompanying images .
a copy of the written consent is available for review by the editor - in - chief of this journal on request .
lumbar hernias are rare and good history and general physical examination can ru... | lumbar hernias are uncommon and about 300 cases have been reported till date . they commonly occur due to trauma , surgery and infection . they are increasingly being reported after motor vehicle collision injuries . however , spontaneous lumbar hernias are rare and are reported infrequently .
it is treated with diff... |
gastroesophageal reflux disease ( gerd ) is one of the most frequently occurring benign functional disorders in western industrial countries .
the effectiveness of laparoscopic antireflux surgery for recalcitrant gerd has been clearly demonstrated in several series .
these laparoscopic results , in combination with... | background and objectives : gastroesophageal reflux disease ( gerd ) is commonly associated with morbid obesity ( mo ) .
antireflux surgery has a higher failure rate in mo and addresses only one of the comorbidities present .
this paper reviews the results of laparoscopic rouxen - y gastric bypass ( lrygbp ) perfor... |
acute epidural hematoma ( edh ) accounts for 2.7% to 11% of traumatic brain injuries ( tbis ) , and if the size is large , the disease leads to devastating results.1712 ) generally , a small edh does not cause neurological deficits , and it has a good prognosis . however , if an initially small edh suddenly expands , t... | objectivea small epidural hematoma ( edh ) that has been diagnosed to be nonsurgical by initial brain computed tomography ( ct ) can increase in size and need surgical removal , resulting in a poor prognosis .
however , there have been few studies , which focused delayed operated edh .
therefore , we analyzed the c... |
asbestos and silica are well - known fibrogenic dusts . however , there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation .
previous studies have shown that asbestos stimulates superoxide anion production in alveolar macropha... | |
duodeno - duodenal intussusception , which involves the distal invagination of a segment of the duodenum , is a rare condition owing to the retroperitoneal fixation of the duodenum , which is sometime absent in cases of intestinal malrotation .
the vast majority ( 8090% ) of cases of intestinal intussusception are se... | highlightsintussusception is not always seen on ultrasonography but can revealed by a ct-scan.any child , and especially those with previous congenital disorders , must undergo upper gi- endoscopy at the presence of intermittent upper gastrointestinal symptoms as vomiting , abdominal pain and gastro - oesophageal reflu... |
it is characterized by autoantibodies that target against liver - specific and non - organ - specific antigens ( 1 ) .
corticosteroids , especially prednisone or prednisolone ( pd ) , have been the key drugs of initial antiinflammatory and immuno - suppressive therapy of autoimmune hepatitis in children ( 2 ) . howev... | prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children . however , long - term use of corticosteroid is associated with the risk of steroid - induced toxicities , and this situation requires newer immuno - suppressive agents for the treatment of autoimmune hepatitis , especiall... |
congenital mitral valve anomalies are very rare clinical entities involving one or more components of the mitral valve apparatus .
the majority of these abnormalities are causing mitral valve insufficiency and commonly presenting in the early part of life .
common clinical presentations include left ventricular out... | a 55-year - old male presented with stroke .
transesophageal echocardiogram and cardiac computed tomography revealed an unrecognized congenital malformation of the anterior mitral leaflet associated with anomalous left coronary circumflex artery , arising from the right coronary artery , diagnosed first by echocardio... |
nontraumatic spontaneous intracranial hemorrhage ( ich ) causes significant morbidity and mortality throughout the world .
ten to 20% of strokes are caused by ich in western countries.6 ) over 45 years of age , ich is common,5)16)21 ) but rare before then .
therefore , the goal of our study was to perform a descrip... | objectivespontaneous intracerebral hemorrhage ( ich ) in young adults is rare . the purpose of this study was to investigate causes , sites and other factors affecting the prognosis of ich in young adults aged 40 years.methodswe reviewed 39 consecutive patients diagnosed with spontaneous ich between january 2001 and j... |
given that almost three quarters of older adults lack decision - making capacity when urgent choices about life - sustaining treatment need to be made , older adults have long been encouraged by nurses and other health care providers to express their wishes for health care while they are healthy enough to meaningfully ... | older adults have long been encouraged to maintain their autonomy by expressing their wishes for health care before they become too ill to meaningfully participate in decision making .
this study explored the manner in which community - dwelling adults aged 55 and older plan for serious illness .
an online survey w... |
lung cancer is the leading cause of cancer death in most countries . although much effort has been made over the last few decades to improve the survival of lung cancer patients , overall five - year survival rates remain unsatisfactorily low ( 14% in the u.s.a . )
brain metastasis ( bm ) is a major cause of the low ... | the purpose of this prospective study was to determine whether using magnetic resonance imaging ( mri ) for early screening for brain metastases ( bm ) can improve quality of life , survival in patients with non - small cell lung cancer ( nsclc ) .
the study group comprised 183 patients newly diagnosed with nsclc .
... |
hyponatraemia is the most commonly encountered electrolyte abnormality in hospitalised patients particularly in the intensive care unit ( icu ) . in a post - surgical icu ,
the syndrome of inappropriate secretion of antidiuretic hormone ( siadh ) is a frequent cause for hyponatraemia .
vaptans , a new group of vaso... | background and aims : conivaptan , a vasopressin receptor antagonist , is commonly used for the treatment of euvolaemic , hypervolaemic hyponatraemia .
usually , an intravenous ( iv ) bolus followed by infusion is administered for many days .
we decided to assess the effectiveness of single dose conivaptan for corr... |
the introduction and subsequent sustained global spread in the human population of influenza a viruses with a novel hemagglutinin ( ha ) subtype leads to an influenza pandemic .
the novel influenza pandemics that occurred during the last century resulted in considerable mortality and morbidity .
genetic investigati... | until 2001 , h6n1 influenza viruses in the hong kong bird markets were represented by a single stable a / teal / hong kong / w312/97-like lineage . beginning in 2001 , despite a reduction in overall prevalence , an increase was observed in the number of h6 viruses isolated from chickens and other hosts . to assess any ... |
using best evidence to inform healthcare decisions is widely recognized as a key
competency for all healthcare professionals .
academic institutions are implementing evidence - based healthcare
( ebhc ) as part of learning in the curriculum of healthcare professionals .
these
curricula usually cover critical ... | abstractaim : medical student educators play critical roles in evidence - based healthcare ( ebhc )
teaching and learning and as role models practicing ebhc .
this study assessed
their confidence to practice and teach ebhc , their attitude to ebhc and barriers
to practicing and teaching ebhc.methods:we conducte... |
the regulated expression of different families of retrotransposons and dna transposons has been described in different tissues and species . however , a detailed analysis of the transcripts or their temporal and spatial expression patterns has been reported in only a few cases . during drosophila embryogenesis ,
spat... | transposable elements ( retrotransposons and dna transposons ) comprise a large proportion of animal genomes , for example 20% in d. melanogaster , 36% in x. tropicalis and 45% in humans . after invading a new genome , the transposable element increases its copy number and subsequently accumulates mutations .
these m... |
we obtained formalin - fixed , paraffin - embedded tissue sections from 30 leiomyosarcoma patients at the university of texas md anderson cancer center ( mdacc ; houston , texas , usa ) .
these included samples from the retroperitoneum ( n = 12 ) , gastrointestinal tract ( n = 9 ) , uterus ( n = 6 ) , and skin ( n = ... | prune2 plays an important role in regulating tumor cell differentiation , proliferation , and invasiveness in neuroblastoma .
our previous study revealed that prune2/obscn two - gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor .
however , the associatio... |
child abuse is defined as any physical or emotional injury which causes harm or substantive risk of harm to the child 's health or welfare .
it includes sexual abuse , neglect , or being physically dependent upon an addictive drug at birth .
types of child abuse , include physical abuse , emotional abuse and neglec... | background : family violence , including child abuse , neglect , and domestic violence , is a public health problem .
the aim of this study was to provide data on prevalence and factors of orofacial lesions relating child abuse in iran to lend evidence to support preventing child abuse.materials and methods : the ove... |
oncocytes are observed in lesions of several organs such as the thyroid , kidney , pancreas , ovary , liver , and salivary gland . in the salivary glands ,
oncocytes are known to arise in warthin tumor , oncocytoma , oncocytic carcinoma , and oncocytosis .
oncocytosis is a rare non - neoplastic lesion that is class... | multifocal adenomatous oncocytic hyperplasia ( maoh ) is a non - neoplastic lesion that is classified as oncocytosis .
maoh is a rare entity of the parotid gland and accounts for approximately 0.1% of salivary gland lesions . here
, we report a case of maoh of the parotid gland .
the patient was a 71-year - old w... |
a 59 year - old female with a family history of mcd presented to our clinic with progressive loss of vision over a 40-year period .
there were multiple irregular grayish - white , dense , poorly delineated spots in the stroma . because her parents died at an early age , her family history was unclear .
of note , he... | to report a novel mutation within the chst6 gene , as well as describe light and electron microscopic features of a case of macular corneal dystrophy . a 59-year old woman with
macular corneal dystrophy in both eyes who had decreased visual acuity underwent penetrating keratoplasty .
further studies including light... |
various methods including chemical , electro - chemical , and physical deposition techniques have been employed to synthesize 1d zno nanostructures [ 3 - 5 ] . on the other hand ,
the wet - chemical methods [ 6 - 8 ] have been used for producing varied zno one - dimensional ( 1d ) nanostructures , such as nanotube , ... | zno nanorod arrays are prepared on a silicon wafer through a multi - step hydrothermal process . the aspect ratios and densities of the zno nanorod arrays
are controlled by adjusting the reaction times and concentrations of solution .
the investigation of field emission properties of zno nanorod arrays revealed a s... |
the adverse consequences of the acquired immune deficiency syndrome ( aids ) or t cell immunodeficiency provide evidence of the vital role of cytotoxic t - lymphocytes ( ctl ) in the immune response .
indeed , ctl are well - known elements of the immune response to virus - infected , tumour and allogeneic cells [ 13 ... | cytotoxic t - lymphocytes ( ctl ) are famous for their ability to kill tumor , allogeneic and virus - infected cells .
however , an emerging literature has now demonstrated that ctl also possess the ability to directly recognize and kill bacteria , parasites , and fungi . here
, we review past and recent findings d... |
skin tissue integrity is a crucial factor to maintain the homeostasis generated through physical barriers , separating the organism from the environment .
every disruption of dermal integrity triggers a complicated cascade of events , including rapid blood clot formation , inflammatory response , and wound healing , ... | skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components , accompanied by the accumulation of a vast number of myofibroblasts .
scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response... |
acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection occurring mostly in intensive care units.1 members of genus acinetobacter is gram negative , nonmotile nonspore forming encapsulated coccobacilli belonging to family neisseriaceae.2 it is an opportunistic pathogen... | background : antibiotic - resistant acinetobacter nosocomial infection is a leading problem .
it acts as an opportunistic pathogen to cause a wide spectrum of infection including nosocomial pneumonia , meningitis , endocarditis , skin and soft tissue infections , urinary tract infection , conjunctivitis , burn wound ... |
bone grafting is common in neurosurgery for spinal fusion and in orthopedic reconstruction surgery for revision hip replacement , repairing skeletal defects after a trauma , and for support when removing a tumor .
three types of bone graft are used : autograft ( autologous graft ) , allograft , and alloplastic graft ... | abstractbone grafting is a commonly used orthopedic surgical procedure that will provide bone formation in bone defects or regions of defective bone healing .
a major complication following bone grafting is a postoperative recipient graft site infection that is associated with substantial mortality and increased use ... |
globally , mother - to - child transmission of hiv-1 results in approximately 370 000 infant infections each year .
hiv-1 early infant diagnosis ( eid ) programs aims to detect hiv infection as early as possible in hiv - exposed infant and to link them to care and treatment .
eid of hiv confers substantial benefit... | objectivethe purpose of this study is to assess the utility of web - based mobile technology monitoring tool , for ensuring linkages , and tracking of hiv - exposed child until 18 months of age.methodsthe early infant diagnosis ( eid ) follow - up system was designed as a tool for reminding the field level staff for f... |
regulation of gene expression is fundamental for the coordinate synthesis , assembly and localization of the macromolecular structures of cells .
this is achieved by a multi - step program that is highly interconnected and regulated at diverse levels ( fig .
it starts in the nucleus , where transcription factors bi... | abstract.post-transcriptional regulation of gene expression plays important roles in diverse cellular processes such as development , metabolism and cancer progression .
whereas many classical studies explored the mechanistics and physiological impact on specific mrna substrates , the recent development of genome - w... |
fetus in fetu ( fif ) was first described by meckel in the early 19th century , and it was defined as a mass containing a vertebral axis often associated with other organs or limbs around this central axis in 19351 ) . since then , this disease entity has been rarely reported .
with advance in prenatal diagnosis tech... | fetus - in - fetu ( fif ) is a rare congenital condition in which a fetiform mass is detected in the host abdomen and also in other sites such as the intracranium , thorax , head , and neck .
this condition has been rarely reported in the literature . herein , we report the case of a fetus presenting with abdominal c... |
during october 1 , 2010july 31 , 2011 , the centers for disease control and prevention ( cdc ; atlanta , georgia , usa ) asked all state public health laboratories to submit pandemic ( h1n1 ) 2009 virus positive respiratory specimens and virus isolates for antiviral susceptibility testing . laboratories were asked to ... | during october 2010july 2011 , 1.0% of pandemic ( h1n1 ) 2009 viruses in the united states were oseltamivir resistant , compared with 0.5% during the 200910 influenza season . of resistant viruses from 201011 and 200910 , 26% and 89% , respectively , were from persons exposed to oseltamivir before specimen collection .... |
the incidence of cutaneous melanoma ( cm ) is rapidly increasing in europe , especially in the caucasian population .
incidences are known to vary amongst white populations , reaching 15 cases per 100,000 inhabitants per year in scandinavia and 57 cases per 100,000 inhabitants per year in mediterranean countries [ 24... | background .
the incidence of cutaneous melanoma is rapidly increasing in europe .
active research is directed toward the identification of naevi as a risk factor . objective .
the aim of our case - control study was to observe different numbers of moles and different mole typology associations in order to evalua... |
head and neck squamous cell carcinoma ( hnscc ) is one of the most prevalent and lethal cancers worldwide ( argiris et al . , 2008 ) . despite recent advances in early detection , surgical techniques , radiation and chemotherapeutic regimes ( temam et al .
2009 ) , the survival rate and quality of life for patients w... | human papillomavirus ( hpv ) infection is well established as an etiological agent responsible for a number of pathologies affecting the stratified epithelia of skin and anogenital sites .
more recently , the infection by ( mucosal ) high - risk hpv types has also been found to be causally associated with squamous ce... |
crohn 's disease ( cd ) is a form of inflammatory bowel disease ( ibd ) affecting the entire gastrointestinal ( gi ) tract [ 14 ] .
cd is characterized by transmural inflammation of gi wall in a noncontiguous pattern anywhere from the mouth to the anus [ 5 , 6 ] .
it is believed that , in genetically predisposed in... | crohn 's disease ( cd ) is a chronic inflammatory bowel disease that can be diagnosed at any age .
there are two major patient groups based on diagnosis of this disease , before or after the age of 20 ( juvenile / adolescent or adult ) , with disease progression in adults usually milder than in juvenile cd patients .... |
contaminated sites are extensively present in europe where approximately 250,000 sites require cleanup interventions , as listed by the european environment agency .
several thousands of these sites are located in italy , and a total of 57 sites , defined in 2009 as national priority contaminated sites ( npcss ) , qu... | the national environmental remediation programme in italy includes sites with documented contamination and associated potential health impacts ( national priority contaminated sites npcss )
. sentieri project , an extensive investigation of mortality in 44 npcss , considered the area of taranto , a npcs where a numb... |
simultaneous bipolar dislocation of the clavicle is uncommon and unusual , although it has been documented as panclavicular dislocation , floating clavicle , and complete dislocation of the clavicle .
a review of the recent literature indicated that most bipolar clavicular dislocations have been treated non - operati... | introduction : simultaneous bipolar dislocation of the clavicle is uncommon and unusual , although it has been documented as panclavicular dislocation , floating clavicle , and complete dislocation of the clavicle .
a review of the recent literature indicated that most bipolar clavicular dislocations have been treate... |
neural stem cells ( nscs ) are multipotent cells that can give rise to various cell types in the central nervous system ( cns ) , including neurons , astrocytes , and oligodendrocytes ( alvarez - buylla et al . , 2002 ) .
in adult mammals , neurogenesis is limited to two brain regions ; the subventricular zone ( svz ... | in adult mammals , neural stem cells ( nscs ) are found in two niches of the brain ; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus .
neurogenesis is a complex process that is tightly controlled on a molecular level .
recently , micrornas ( mirnas ... |
torus hyperplasia is a very rare condition also known as focal pyloric hypertrophy ( 1 ) .
this lesion is caused by a circular muscle hypertrophy affecting the lesser curvature near the pylorus .
pathogenesis of the lesion is unclear , some considering it as a persistence of infantile pyloric hypertrophy to adultho... | primary or idiopathic hypertrophy of the pyloric muscle in adult , so called torus hyperplasia , is an infrequent but an established entity .
it is caused by a circular muscle hypertrophy affecting the lesser curvature near the pylorus .
since most of the lesions are difficult to differentiate from tumor , distal g... |
the incidence of non - hodgkin lymphoma ( nhl ) is rising worldwide and is higher in developed countries than in africa and asia .
b cell non - hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis c virus ( hcv ) infection . the prevalence of hcv infection in patients with b c... | b cell non - hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis c virus ( hcv ) infection .
the mechanism by which hcv infection leads to lymphoproliferative disorder remains unclear .
our group established hcv transgenic mice that expressed the full hcv genome in b cells ... |
we studied 22 samples , from dogs , cattle , wildlife , and humans in cear , obtained from 1997 to 2003 ( table ) .
samples were antigenically characterized by using a monoclonal antibody ( mab ) panel against the viral nucleoprotein ( 35 ) .
isolates were injected into the brains of suckling mice , and brain impre... | rabies viruses circulating in cear , brazil , were identified by molecular analysis to be related to variants maintained by dogs , bats , and other wildlife .
most of these viruses are associated with human rabies cases .
we document the emergence of a rabies virus variant responsible for an independent epidemic cy... |
toxoplasma gondii ( t. gondii ) is an obligate intracellular protozoan parasite that causes toxoplasmosis , a usually asymptomatic disease in most immune - competent individuals but potentially severe in immune - compromised hosts .
successful control of this pathogen depends on the early production of the proinflamm... | macrophage migration inhibitory factor ( mif ) mediates immunity against toxoplasma gondii infection by inducing inflammatory cytokines required to control the parasite replication .
however , the role of this inflammatory mediator in the cell - mediated immune response against this infection is still poorly understo... |
implantation always involves penetration to the skin and damage of smaller or larger blood vessels through the surgical procedure and the implanted scaffold material will have direct contact with human blood .
scaffolds as medical implants require assessment of hemocompatibility to predict potential procoagulation or... | design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses . in this study ,
single wall carbon nanotubes ( swcnts ) and zein fibrous nanocomposite scaffo... |
the purpose of this study was to investigate the efficacy and safety of fixed dose combination ( fdc ) of olanzapine 5 mg and fluoxetine 20 mg in indian patients with severe or treatment resistant depression .
this was an open , non - comparative study of seven weeks duration with an initial placebo run in period of ... | objective : the purpose of this study was to investigate the efficacy and safety of fixed dose combination ( fdc ) of olanzapine 5 mg and fluoxetine 20 mg in indian patients with severe or treatment resistant depression.design : this was an open , non - comparative study of seven weeks duration with an initial placebo ... |
for ensuring post - endodontic restorations which provide tooth function and form with adequate force distribution , placement of fiber posts to the root canal are used commonly.1 moreover , the placement of a post is often needed for the restoration of a root canal treated tooth in order to support the core material.2... | purposethe aim of this study was to evaluate whether the push - out bond strength varies between oval and circular fiber posts , and to examine the effect on the resin cement thicknesses around the posts.materials and methodseighteen mandibular premolar roots were separated into two groups for oval and circular fiber p... |
pediatric soft - tissue sarcomas ( stss ) account for approximately 7% of all childhood tumors . out
though surgery is the mainstay of treatment , advent of neoadjuvant chemotherapy ( nact ) has reduced the incidence of recurrence / metastasis .
we present a case of ifs with early and unusual distant metastasis , l... | infantile fibrosarcoma ( ifs ) is a rare soft - tissue sarcoma originating from extremities and occasionally from axial soft tissue .
the prognosis is good with favorable long - term survival .
it is rarely metastasizing tumor , the chances being lesser with ifs originating from extremities .
use of neoadjuvant c... |
we studied 1,297 patients with type 1 diabetes from the nationwide finnish diabetic nephropathy study ( finndiane ) .
patients were required to have an onset of diabetes before 35 years of age and initiation of permanent insulin treatment within 1 year of diagnosis .
patients were classified into four groups based ... | objectivemannose - binding lectin ( mbl ) is an essential component of the acute - phase immune response and may thus play a role in the pathogenesis of type 1 diabetes and diabetic nephropathy .
the serum concentration of mbl is mainly genetically determined , and elevated concentrations have been associated with bo... |
gwas2 included 450 unrelated generalized vitiligo patients ( cases ) of non - hispanic / latino european ancestry ( eur ) from north america and europe , who met strict clinical criteria for generalized vitiligo .
controls for gwas2 were 3182 eur individuals not specifically known to have any autoimmune disease or ma... | in previous linkage and genome - wide association studies we identified 17 susceptibility loci for generalized vitiligo . by a second genome - wide association study , meta - analysis , and independent replication study ,
we have now identified 13 additional vitiligo - associated loci , including oca2-herc2 , a regio... |
now they need more attention because as the average life expectancy , elderly population , and subsequent resulting osteoporosis continue to increase , orthopaedic surgeons will get more such cases [ 14 ] .
intertrochanteric fractures in the elderly are associated with high rates of mortality , ranging from 15 to 20%... | background .
intertrochanteric fractures of the proximal femur are one of the most common fractures encountered , and dynamic hip screw with a side plate is the standard treatment . we compared a minimally invasive surgical technique with the conventional surgical technique used in the fixation of intertrochanteric f... |
nucleic acids are highly attractive class of therapeutics due to their potential to regulate any selected gene of interest . given their capacity to modulate conventionally undruggable targets , oligonucleotides ( ons ) have been extensively investigated as potential therapeutics to treat cancer , viral infections , ge... | nucleic acid therapy can be beneficial for the local treatment of gastrointestinal diseases that currently lack appropriate treatments . indeed , several oligonucleotides ( ons ) are currently progressing through clinical trials as potential treatments for inflammatory bowel diseases .
however , due to low uptake of ... |
increasing numbers of aesthetic procedures - especially cosmetic nonsurgical injection procedures - are performed every year ( 1 ) .
these procedures are generally safe , although cosmetic facial filler injections could lead to devastating complications such as blindness .
there are several reports ( most of which ... | cosmetic facial filler - related ophthalmic artery occlusion is rare but is a devastating complication , while the exact pathophysiology is still elusive .
cerebral angiography provides more detailed information on blood flow of ophthalmic artery as well as surrounding orbital area which can not be covered by fundus ... |
with the ever increasing importance of clinical effectiveness , audit and quality assurance ; it is becoming mandatory to grade one 's own treatment results .
the idea of individuals grading their own performance is a self - teaching exercise and improves the quality of future treatment .
the assessment of ortho... | objective : the aim of the study was to evaluate the effect of post- treatment critical evaluation on the quality of orthodontic care in a postgraduate orthodontic clinic.materials and methods : orthodontic treatment outcome of 109 consecutively treated cases was evaluated in phase - i evaluation . following phase - i ... |
concentrations of ambient pm2.5 ( particulate matter < 2.5 microm in aerodynamic diameter ) were associated with increased mortality in two prospective cohort studies . in this paper ,
i assess whether the weight of the evidence supports a causal association .
i assumed the study population in each city to have the... | |
beryllium was released into the air from routine operations and three accidental fires at the rocky flats plant ( rfp ) in colorado from 1958 to 1989 .
we evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks o... | |
the motility of nk cells in tissue or tumor microenvironment is likely driven by chemotactic signaling resulting in an approximation to key sites of interest , although nk cell motility in tumors is also driven by the expression of nkg2d ligands .
therefore , similar to a t - cell sampling dendritic cells , nk cells ... | natural killer ( nk ) cell - mediated cytotoxicity is governed by the formation of a lytic immune synapse in discrete regulated steps , which give rise to an extensive array of cellular checkpoints in accessing nk cell - mediated cytolytic defense .
appropriate progression through these cell biological steps is criti... |
appropriate timing of treatment is the key to successful intensive care ; treatment that is delayed could be as detrimental as treatment that is premature .
therefore , lange and colleagues , in this issue of critical care , reported on the time course of the expression of the different isoforms of the nitric oxide s... | appropriate timing of treatment assumes particular importance in critical care .
lange and colleagues recently reported on the time course of the different nitric oxide synthase ( nos ) isoforms , nitrosative stress , and poly(adp - ribosylation ) during pseudomonas aeruginosa pneumonia - induced ovine septic shock .... |
steroid hormones have been traditionally associated with regulation of peripheral organs , associated with stress ( corticosterone ) or with gonadal function ( estrogen and androgens ) . over the years , it became evident that these hormones also act within the hypothalamus , in a feedback regulatory loop , to affect t... | several new observations have shifted the view of the hippocampus from a structure in charge of cognitive processes to a brain area that participates in the formation of emotional memories , in addition to its role in cognition . specifically , while the dorsal hippocampus is involved in the processing of cognitive mem... |
primary amenorrhea is the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older .
common hormonal cause of primary amenorrhea includes pituitary dysfunction , chronic systemic disease , and absent ovarian function .
gonadal failure in genetically xx individuals is o... | background : primary amenorrhea is defined as the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older .
hormonal disorders are main causes of primary amenorrhea .
common hormonal cause of primary amenorrhea includes pituitary dysfunction and absent ovarian functio... |
we report the case of a 13yearold boy with neuromuscular proximal thoracic scoliosis who was found to have significant torsion of the left main bronchus during general anesthesia for posterior instrumented spinal fusion of t2 to l4 .
this patient had a background history of multicore myopathy , which resulted in prog... | key clinical messagepulmonary function tests such as flowvolume loops and reconstructive radiological imaging may aid the detection of large airway obstruction prior to corrective surgery for severe scoliosis .
intraoperative use of halogravity traction may help to reduce the severity of the scoliosis , and thus the ... |
portal hypertension , always accompanies by cirrhosis , can lead to lots of complications including varices hemorrhage , ascites , hypersplenism and hepatic encephalopathy .
the risk of varices bleeding in patients with portal hypertension was approximately 30% over 2 years .
nowadays , the treatment for patients w... | background : the purpose of this article was to clarify the optimal management concerning transjugular intrahepatic portosystemic shunts ( tipss ) and surgical shunting in treating portal hypertension.methods:all databases , including cbm , cnki , wfpd , medline , embase , pubmed and cochrane up to february 2014 , were... |
the frequency of prenatal hydronephrosis diagnosed by ultrasound has been reported to be 0.65.4% of newborns [ 39 ] . among infants with hydronephrosis ,
hydronephrosis has been reported to be transient or physiological in nature ( 4188% ) or secondary to pelviureteric junction obstruction ( 1030% ) , vesicoureteric ... | backgroundhydronephrosis is a common congenital condition .
the detection of fetal hydronephrosis by ultrasound presents a treatment dilemma .
this study aims to examine postnatal follow - up and treatment for hydronephrosis diagnosed prenatally.material/methodsthis was a retrospective study of 210 infants with hyd... |
d - penicillamine has been known as one of the agents that are able to induce pemphigus ( 1,2 ) .
n-(2-mercapto-2-methylpropionyl)-l - cysteine ] is a thiol compound contained two free sulfhydryl groups , whereas d - penicillamine has only one sulfhydryl radical ( 3 ) .
while drug - induced pemphigus was not infreq... | bucillamine is a disease modifying anti - rheumatic drug , structurally similar to d - penicillamine .
although d - penicillamine - induced pemphigus has been not infrequently demonstrated , pemphigus associated with bucillamine was rarely reported .
we describe a patient complicating pemphigus vulgaris after bucil... |
the - and -lactam
scaffolds are found in various
biologically relevant compounds . additionally , these core structures
are crucial intermediates in the synthesis of various natural products
as well as pharmaceuticals , prompting the development of new methods
for the synthesis of these valuable structures . ... | sulfone - substituted
- and -lactams have been prepared
in a single step with high diastereoselectivity .
sulfonylglutaric
anhydrides produce intermediates that readily decarboxylate to provide
-lactams with high diastereoselectivity .
substituents at the
3- or 4-position of the glutaric anhydride induce ... |
almost 40%60% of patients with colorectal cancer ( crc ) develop metastasis , predominantly in the liver .
tumor angiogenesis has been implicated as a major factor in the development and spread of these metastases .
the recent discovery of vascular endothelial growth factor - c ( vegf - c ) and vegf receptor-3 ( ve... | background . colorectal cancer ( crc ) is the most common form of cancer diagnosed in australia across both genders .
approximately , 40%60% of patients with crc develop metastasis , the liver being the most common site .
almost 70% of crc mortality can be attributed to the development of liver metastasis .
this ... |
carotid blow - out syndrome is the most feared complication in head and neck surgery .
the syndrome occurs in 3% to 4% of all head and neck cancer patients and is easy to happen following fistula formation , bad wound healing and tumor recurrence .
carotid blow - out syndrome presents an average of 2.7 years after ... | abstractthe patient had thyroid cancer and underwent subtotal thyroidectomy .
local recurrence occurred on both sides 5 years and 6 months later .
the sterno - hyoid muscle and sterno - thyroid muscle were severed and the tumor around the cricoid cartilage was removed .
the tumor extended into the space between t... |
errors in the health care system are due to a diverse interaction of human behavior , socio - cultural aspects , technical aspects of the system , as well as a range of system weaknesses . various categories of errors present as an overlap between human and system causes .
when working conditions lead to circumstance... | background : a limited framework of incident reporting exists in most of the health care system in pakistan .
this poses a risk to the patient population and therefore there is a need to find the causes behind the lack of such a system in healthcare settings in pakistan.aims:to determine the attitudes and perceived b... |
sulfonamides and sulfones
serve both as useful intermediates in
organic synthesis and as important target
molecules in their own right . for example , enantioenriched
secondary benzylic sulfonamides and sulfones display a range of biological
activity ( e.g. , protein tyrosine phosphatase inhibitor , antisepsi... | the
development of efficient methods for the generation of enantioenriched
sulfonamides and sulfones is an important objective for fields such
as organic synthesis and medicinal chemistry ; however , there have
been relatively few reports of direct catalytic asymmetric approaches
to controlling the stereochem... |
gold nanorods ( gnrs ) are anisotropic particles
whose surface plasmon
modes can be tuned as a function of aspect ratio , with optical resonances
ranging from visible to near - infrared wavelengths .
gnrs
have been investigated as contrast agents for optical biomedical imaging
modalities such as optical coh... | stable
aqueous dispersions of citrate - stabilized gold nanorods
( cit - gnrs ) have been prepared in scalable fashion by surfactant exchange
from cetyltrimethylammonium bromide ( ctab)-stabilized gnrs , using
polystyrenesulfonate ( pss ) as a detergent .
the surfactant exchange
process was monitored by inf... |
many psychoactive substances have therapeutic function as analgesics or anesthetics and high addiction potential ( 1 ) .
are commonly used on the other hand an opioid consumption is traditionally common in iran .
the effects of different addictives on body systems have been reported ; however , there is not enough ... | background : psychoactive substances affect mainly central nervous system and brain function causing changes in behavior.objectives:the purpose of this study was to determine the effects of different psychoactive substances on serum biochemical parameters.patients and methods : the study included 324 drug dependents , ... |
research interest is increasing in biomaterials with the potential to stimulate bone healing have gained interest to improve treatment outcome for patients with osteoporotic fractures .
calcium phosphate cements ( cpc ) has been used in bone surgery for many years .
the bio - inspired combination of the inorganic c... | backgroundthe aim of the current study was to measure and compare the effect of various biomaterials for the healing of osteoporotic bone defects in the rat femur using 18f - sodium fluoride dpet-ct.material/methodsosteoporosis was induced by ovariectomy and a calcium - restricted diet .
after 3 months , rats were op... |
m. tuberculosis isolates were obtained from the laboratory of mycobacteriology of the institut pasteur de tunis as part of the national tuberculosis surveillance program . all samples ( 884 specimens ) from patients with suspected tb residing in northern tunisia ( bizerte ) from august 2001 to october 2003 were forward... | multidrug - resistant tuberculosis was diagnosed in 21 hiv - negative , nonhospitalized male patients residing in northern tunisia .
a detailed investigation showed accelerated transmission of a mycobacterium tuberculosis clone of the haarlem type in 90% of all patients .
this finding highlights the epidemic potent... |
the goals of surgical management include correction and maintenance of sagittal and coronal alignment , establishment of length and rotation , and early functional range of movements of knee and ankle .
interlocking nailing of tibial fractures is desirable because this technique allows some load sharing , spares extr... | aim . to evaluate the clinical use of blocking screws as a supplement to stability in distal tibial metaphyseal fractures treated with statically locked intramedullary nail .
main outcome measurement . alignment and reduction
preoperatively , postoperatively , and at healing were the main outcome measured with an e... |
this was a retrospective study that included consecutive cases undergoing surgery for primary rhegmatogenous rd in patients with pseudophakia after phacoemulsification between the dates of january 2000 and june 2008 that had a follow - up duration of at least 12 months .
eyes were excluded from the study if they had ... | purposeto evaluate the clinical features and surgical outcomes for primary rhegmatogenous retinal detachments ( rds ) in patients with pseudophakia after phacoemulsification.methodsthe medical records of patients with pseudophakia after phacoemulsification and intraocular lens implantation who had undergone surgery for... |
the patient was an 11-year - old boy with no family history of optic neuropathy or dystonia .
he presented with focal dystonia in the right upper limb at 3 years of age , and his disease progressed over 4 years to dystonia in both the upper and the lower limbs on his dominant right side . at 5 years of age
however ... | this article reports the case of an 11-year - old boy with progressive dystonia caused by the homoplasmic g14459a mitochondrial dna mutation .
the patient presented with focal dystonia in the right upper limb at 3 years of age , which progressed over 4 years to exhibit dystonia in both the upper and lower limbs . at ... |
fibrous dysplasia of bone is characterized by the replacement of medullary bone with fibro - osseous tissue .
this results in the distortion and overgrowth of bone , leading to characteristic deformities . based on the bony involvement , fibrous dysplasia
is divided into three types : monostotic , polyostotic , and... | mccune albright syndrome ( mas ) comprises a triad of fibrous dysplasia of bone , caf - au - lait macule , and endocrinopathy .
the disease is due to activating mutation of g protein - coupled receptor leading to hyperfunction of glands .
hansen 's disease is caused by infection with mycobacterium leprae and is se... |
pseudouridine ( ) is the most abundant post - transcriptional rna base modification and the enzymes responsible for this isomerization of uridine and the positions modified in the rnas , are conserved ( 14 ) .
this modification is important in the structure and function of small rnas ( 511 ) , including small nuclea... | pseudouridine synthase 1 ( pus1p ) is an unusual site - specific modification enzyme in that it can modify a number of positions in trnas and can recognize several other types of rna .
no consensus recognition sequence or structure has been identified for pus1p .
human pus1p was used to determine which structural o... |
midfacial defects are classified as midline midfacial defects , that include the nose and/or upper lip ; and lateral defects , which include the orbital contents and cheek .
facial prosthesis is generally considered over surgical reconstruction to restore function and appearance in patients with facial defects that r... | facial prosthesis is generally considered over surgical reconstruction to restore function and appearance in patients with facial defects that resulted from cancer resection .
retention of the prosthesis is challenging due to its size and weight .
retention can be achieved by using medical grade adhesives , resilie... |
the incidence of well - differentiated thyroid carcinoma , particularly papillary cancer , has been increasing since the last 2030 years . the surveillance , epidemiology and end results ( seer ) database shows more than a 2-fold increase in thyroid cancer since 1995 .
an important contributing factor for the increas... | clinical and pathological characteristics of incidental papillary thyroid microcancer cases , surgical , medical , and nuclear treatment methods , and patients ' outcome were studied during follow - up period of 102 months .
we studied 37 patients with incidental papillary thyroid microcancer ( i - ptm ) .
the surg... |
misdiagnosis of bipolar disorder is a potentially serious problem for patients , which sometimes leads to inappropriate treatment.1 however , it is not unusual for bipolar disorder to be misdiagnosed as a major depressive disorder.2 previous studies have shown that the proportion of cases of bipolar disorder misdiagnos... | misdiagnosis of bipolar disorder is a serious , but not unusual problem for patients . nevertheless , there are few biomarkers for distinguishing unipolar and bipolar disorder .
near - infrared spectroscopy ( nirs ) is a noninvasive and useful method for the measurement of hemoglobin concentration changes in the cort... |
chronic subdural hematoma ( csdh ) is a rare complication of unruptured aneurysm clipping surgery5,12 ) . because csdh signs and symptoms may appear slowly ,
it can cause problems such as headache , dizziness , seizure , and hemiparesis , and requires surgical drainage .
mori et al.11 ) reported severe complication... | objectivechronic subdural hematoma ( csdh ) is a rare complication of unruptured aneurysm clipping surgery .
the purpose of this study was to identify the incidence and risk factors of postoperative csdh after surgical clipping for unruptured anterior circulation aneurysms.methodsthis retrospective study included 518... |
helicobacter pylori have infected nearly half of the world s population . in the developing countries , more than 90% of adults
are typically infected during their early childhood , and once acquired the infection would last for several decades ( 1 ) .
helicobacter pylori infection is the main cause of gastritis an... | background : persistent helicobacter pylori infection confers an increased risk for serious illnesses such as peptic ulcers and gastric cancer .
various cytokines are involved in the regulation of inflammatory immune response in h. pylori - infected gastric mucosa.objectives:the current study aimed to obtain evidence... |
tuberous sclerosis complex ( tsc ) is a genetic disorder that can affect almost all organ systems .
renal manifestations occur with high frequency , the most prevalent being angiomyolipoma ( aml ) .
tsc - associated amls tend to be larger , more numerous , and more likely to cause spontaneous hemorrhage compared wi... | renal calculi in patients with renal angiomyolipomas are difficult to treat because of the hemorrhagic potential of these tumors .
we describe the case of a 65-year - old man having tuberous sclerosis complex - associated multifocal renal angiomyolipomas with a large renal calculus . the patient presented with left f... |
the diagnosis of unexplained syncopal episodes and sustained palpitations remains a difficult task in clinical cardiology .
standard 24 h holter monitoring has a low diagnostic yield , while implantable loop recorder ( ilr ) has a higher diagnostic yield , but it is expensive and mildly invasive , making its role in ... | aimssynarr - flash study ( monitoring of syncopes and/or sustained palpitations of suspected arrhythmic origin ) is an international , multicentre , observational , prospective trial designed to evaluate the role of external 4-week electrocardiogram ( ecg ) monitoring in clinical work - up of unexplained syncope and/or... |
conflict of interest : jjf is a consultant for nkt therapeutics and receives research funding from nkt therapeutics and astellas .
red cell transfusions are frequently used to treat severe anemia and to reduce the effects of sickle cells . unlike many patient populations , patients with scd have a much higher risk of... | in patients with sickle cell disease , hyperhemolysis is a rare but life - threatening complication of transfusion . in this case report , we describe a 61 year - old woman with hemoglobin sickle cell ( sc ) disease and history of alloimmunization who developed hyperhemolysis associated with a transfusion .
she was f... |
the vertebral fractures is the most common complications of osteoporosis.13 ) these fractures result in significant mortality and morbidity including prolonged and intractable pain.4,13 ) percutaneous vertebroplasty , a therapeutic procedure for filling the collapsed vertebral body with polymethylmethacrylate , provide... | we experienced a 73-year - old male with lumbar nerve root compression due to leakage of bone cement after vertebroplasty .
he was underwent vertebroplasty for acute osteoporotic l4 compression fracture at our hospital .
after vertebroplasty , his back pain was improved but right leg pain was newly developed .
lu... |
stridor in children is usually due to airway pathology but neurological conditions causing stridor are not infrequent . in cases with an underlying neurological pathology causing stridor , the treatment of the underlying cause usually relieves the stridor .
we report the association of stridor in a child presenting w... | stridor in children is usually , but not always caused by airway pathology .
the anesthesiologists should have a sound knowledge of the neurological associations of stridor and its management .
in such cases , prompt treatment of the neurological pathology usually resolves the stridor and may prevent unnecessary ai... |
the success of dental implant is primarily based on good osseointegration , which depends on the biocompatibility of the implant material and implant surface properties , as well as on the quantity and quality of remaining tissue.1 commercially pure titanium and titanium alloys are traditional materials used in most co... | purposethis study was performed to define attachment and growth behavior of osteoblast - like cells and evaluate the gene expression on zirconia compared to titanium.materials and methodsmc3t3-e1 cells were cultured on ( 1 ) titanium and ( 2 ) zirconia discs .
the tetrazolium - based colorimetric assay ( mtt test ) w... |
techniques for instrumented fixation and fusion of the cervical spine have rapidly advanced in the past 30 years .
these techniques have helped surgeons adequately manage complex trauma , tumor , and degenerative pathologies .
hadra in 1890 described the use of wiring and graft techniques to perform the first spina... | study design : a multicenter , retrospective case series.objective:in the past several years , screw fixation of the cervical spine has become commonplace . for the most part ,
this is a safe , low - risk procedure . while rare , screw backout or misplaced screws can lead to morbidity and increased costs .
we repor... |
biological variation allows for a unique craniofacial character and many asymmetries found in each individual .
a neurodevelopmental disorder has been defined as an impairment of the growth and development of the brain or central nervous system .
a narrower use of the term refers to a disorder of the brain function... | background : abnormal brain development due to neurodevelopmental disorders in children has always been an important concern , but yet has to be considered as a significant public health problem , especially in the low- and middle - income countries including nigeria.aims:the aim of this study is to determine whether a... |
the verbal informed patient consent was acquired for the case report publication during the acute rehabilitation .
institutional review board approval was not sought for this case report . whether a patient visits a clinic or
is admitted to the hospital , the importance of a detailed physical examination must be em... | this case report describes the detection of homonymous hemianopsia and delirium during the admission physical examination of a patient with esophageal adenocarcinoma , resulting in the new diagnosis of subacute hemorrhagic stroke .
the poststroke visual field defect can result in significant disability and reduction ... |
higher energy intake than expenditure causes excessive accumulation of fat and leads to the development of obesity and associated metabolic disorders , which has reached epidemic proportions not only in developed countries but worldwide .
furthermore , obesity can lead to the development of various co - morbidities ,... | backgroundfibroblast growth factor 21 ( fgf21 ) belongs to the large family of fibroblast growth factors ( fgfs ) .
even though fgf signaling has been mainly implicated in developmental processes , recent studies have demonstrated that fgf21 is an important regulator of whole body energy expenditure and metabolism , ... |
endometriosis affecting the rectum accounts for a small but significant group of women with severe pelvic pain . perhaps because of the inadequacy of conservative or medical measures , many authors advocate the complete surgical removal of rectovaginal disease , even if surgery involving the rectum is required .
we r... | background : anterior rectal resection is sometimes necessary to treat deeply infiltrating rectovaginal endometriosis . we describe a completely laparoscopic approach as a new way of excising rectal endometriosis that can be used without opening any part of the rectum .
this avoids opening the abdomen or any risk of ... |
thymic carcinoma is an aggressive anterior mediastinal malignancy that can cause severe chest pain , although its incidence is rare .
echocardiography is useful for assessing chest pain in the emergency room , but the diagnosis of an extracardiac mass can be missed .
the purpose of this report is to describe the va... | we report a case of thymic carcinoma that was initially detected by echocardiography in an 80-year - old male who visited the emergency room for chest pain and had a history of myocardial infarction and percutaneous coronary intervention .
transthoracic echocardiography showed a huge extracardiac mass that was locate... |
bromodomains are epigenetic
readers that specifically recognize
acetyl - lysine ( kac ) marks on proteins . targeting
this protein interaction
module with small molecules has recently emerged as a potential therapeutic
strategy for the treatment of several diseases including cancer and
inflammation . to dat... | the
p300/cbp - associated factor plays a central role in retroviral
infection and cancer development , and the c - terminal bromodomain provides
an opportunity for selective targeting . here
, we report several new
classes of acetyl - lysine mimetic ligands ranging from mm to low micromolar
affinity that we... |
every human voice is unique as it was found to be quantitatively composed of components called phonemes that have a pitch , cadence , and inflection .
hence human voice has been used as one of the popular biometrics in biosecurity applications ; it can be used to authenticate a person 's identity ( identification )... | voice biometrics has a long history in biosecurity applications such as verification and identification based on characteristics of the human voice .
the other application called voice classification which has its important role in grouping unlabelled voice samples , however , has not been widely studied in research ... |
medical doctors move across borders being motivated by higher salaries , better working conditions , new professional experience , and training and career opportunities . in europe ,
migration of medical doctors has been observed since the 1940s and has shown various dynamics over the years .
european integration h... | this chapter aims at providing an insight into some major aspects linked to migration of medical doctors within europe .
the article describes main factors which contribute to doctors migration .
further , the current and future mobility trends in europe are discussed .
a major part of this chapter is dedicated t... |
imipramine was found to improve mood while being used in a protocol to search for an antipsychotic : ' iproniazid , a drug used in the treatment of tuberculosis , was likewise found to have beneficial effects on mood .
the former , a tricyclic antidepressant ( tca ) , and the latter , a monoamine oxidase inhibitor ( ... | the current clinical use of psychotropic drugs is transnosologically oriented .
this is facilitated by the current classification of mental disorders ( international classification of diseases , 10th revision [ icd-10 ] ) and is perhaps justified if depression and psychosis ( taken here as examples ) are considered a... |
africa , the population size of the city of tshwane in 2011 was roughly equal to 3 million .
the city is home to over 5,000 businesses out of which 1,603 businesses operate within the central business district of tshwane , known as pretoria . according to the annual report issued by the city of tshwane metropolitan m... | objective . the objective was to investigate factors that affect the efficient management of solid waste produced by commercial businesses operating in the city of pretoria , south africa .
methods .
data was gathered from 1,034 businesses .
efficiency in solid waste management was assessed by using a structural ... |
parkinson 's disease ( pd ) is a neurodegenerative condition characterised clinically as a movement disorder consisting of bradykinesia , rigidity and rest tremor , as a consequence of striatal dopamine depletion secondary to degeneration of the dopaminergic neurons of the substantia nigra .
in addition , pathology i... | parkinson 's disease ( pd ) is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia nigra .
the motor disorder responds well to dopamine - replacement therapies , though these result in significant adverse effects due to non - physi... |
panoramic radiography is a cost - effective , low - dose method used in dental radiology for evaluating oral health status in routine dental practice.1 this technique allows examination of the maxillary and mandibular arches and their supporting structures on a single image.23 the advantages of panoramic radiography ar... | purposethe aim of this study was to determine the frequency of significant panoramic radiographic findings and eventual treatment requirements before conventional or implant supported prosthetic treatment in asymptomatic edentulous patients.materials and methodsa total of 743 asymptomatic edentulous patients were retro... |
spinal epidural lipomatosis ( sel ) is a rare disease that is characterized by pathologic overgrowth of lumbar or thoracic epidural fat tissue .
although the etiology of sel is not known , sel has been frequently diagnosed in obese patient groups and exogenous steroid administration groups , so steroid metabolism is ... | spinal epidural lipomatosis ( sel ) is an abnormal localized accumulation of fat tissues in the epidural space .
it is strongly related with steroid administration .
the symptoms of sel are various and range from back pain to paraplegia . in severe cases ,
decompressive laminectomy is the choice of treatment .
... |
increased long - term survival following effective treatment of childhood lymphomas has placed greater emphasis on residual sequelae of therapy for lymphoma and the impact of these sequelae as the cause of further morbidity and mortality . following treatment of childhood hodgkin 's disease ,
cardiac pathology is s... | objectives . we studied long - term effects of therapy for childhood lymphoma on cardiac function . design and patients .
we prospectively evaluated 45 survivors of childhood lymphoma , using clinical parameters , electrocardiography and echocardiography .
further comparisons were made between lymphoma subgroups an... |
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