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haemophilus spp . generally colonize the upper respiratory tract and can cause infections such as bronchitis , sinusitis , epiglottitis , pneumonia and meningitis .
h. influenzae has been reported as a rare cause of genitourinary tract infection such as urinary tract infection , , , , , pyelonephritis , , prostatitis... | haemophilus species are known to colonize the upper respiratory tract and can cause infections .
however haemophilus influenzae has been rarely described as a cause of genitourinary tract infection .
we report a 44-year - old nonimmunocompromised japanese man with bacteremic pyelonephritis caused by a nontypable h.... |
the long - term survival of patients with hematological malignancies has improved dramatically over the past decades . nowadays ,
about 40% of patients with acute leukemia or high - grade non - hodgkin lymphoma survive for more than 5 years and about 30% of these patients can be cured . unfortunately , owing to their... | the spectacular improvement in long - term prognosis of patients with hematological malignancies since the 1980s , coupled with the subsequent improvement over the past decade in short- and mid - term survival in cases of critical illness , resulted in an increasing referral of such patients to the icu . a remaining qu... |
chronic hepatitis c ( chc ) is a major health care burden and a leading cause of end - stage liver disease and hepatocellular carcinoma ( hcc ) worldwide .
although non - uniform distributions of chc in certain areas complicate the establishment of global and regional epidemiology , the global prevalence of chc has b... | background : single - nucleotide polymorphisms ( snp ) in the inosine triphosphate pyrophosphatase ( itpa ) gene correlate with ribavirin ( rbv)-induced anemia in patients with chronic hepatitis c ( chc ) receiving combination therapy .
managing anemia is an early priority in the treatment process.objectives:the aim ... |
endometrial carcinoma is the most common cancer of the female genital tract in the western world .
endometrial carcinomas are generally thought to have a favorable prognosis due to early detection , and the majority of tumors are detected in early stages .
however , in fact this is not fully true , and there are im... | background . the aim was to evaluate predictive and prognostic factors in a large consecutive series of endometrial carcinomas and to discuss pre- and postoperative risk groups based on these factors .
material and methods . in a consecutive series of 4,543 endometrial carcinomas predictive and prognostic factors wer... |
fistula - in - ano is an abnormal hollow tract lined by unhealthy granulation tissue connecting a primary opening in the anal canal to a secondary opening in the perianal skin .
the fistula tract may be single or multiple and may extend from the same primary opening .
it is nearly always caused by a previous anorec... | background : fistula - in - ano when complicated by fournier 's gangrene is an unusual finding and always carries high morbidity .
this study details our experience in managing 10 cases.methods of study : case files of all patients managed in university of maiduguri teaching hospital and federal medical center of yol... |
congenital coarctation of the aorta is a narrowing of the descending aorta which typically is located at the ligamentum arteriosum just distal to the left subclavian artery .
this condition may be undiagnosed until adult life , when the clinical presentation most often is high blood pressure ( bp ) in both or more se... | the present case shows that a normal brachial blood pressure ( bp ) does not exclude severe coarctation and should be considered in normotensive patients presenting with a systolic murmur and/or unexplained severe left ventricular hypertrophy .
congenital coarctation of the aorta is a narrowing of the descending aort... |
multistep skin carcinogenesis assays were performed with mice with keratinocyte - specific deletion of the cnb1 gene ( cnb1xk5-crepr1)3 in parallel with cre - negative controls ( cnb1 ) .
detailed conditions for these assays as well as chromatin immunoprecipitation , immunoblotting , immunofluorescence , senescence -... | calcineurin inhibitors such as cyclosporin a ( csa ) are the mainstay of immunosuppressive treatment for organ transplant recipients .
squamous cell carcinoma ( scc ) of the skin is a major complication of treatment with these drugs , with a 65100 fold higher risk than in the normal population1 .
by contrast , the ... |
micrornas ( mirnas ) are single stranded non - coding rna molecules of 22 nucleotides ( nt ) that regulate gene expression via post - transcriptional and/or translational repression ( ambros , 2004 ) .
primary mirna ( pri - mirnas ) are transcribed in the nucleus by rna polymerase ii or iii , where 70 nt stem - loop ... | micrornas ( mirnas ) are small non - coding rnas ( 22 nucleotides ) regulating gene expression at the post - transcriptional level . by directing the rna - induced silencing complex ( risc ) to bind specific target mrnas
, mirna can repress target genes and affect various biological phenotypes .
functional mirna ta... |
prostate cancer , one of the most commonly diagnosed male malignancies in western countries , is now the leading cause of cancer - related death in men . over the years
, genetic epidemiological evidence has accumulated in favor of a considerable hereditary component in prostate cancer susceptibility . genetic linkag... | the sperm protein associated with the nucleus in the x chromosome ( spanx ) gene family encodes for proteins that are not only expressed in germ cells , but also in a number of tumors . in addition , spanx genes map in an interval of the x chromosome ( namely , xq27 ) , which has been found to be associated with famili... |
gli2 mice , in which the bovine k5 promoter drives the constitutive expression of mouse gli26 , develop bcc and bfh6,7 , which are both linked to deregulated hh signaling in humans7,8 .
gli2 mice show a reproducible pattern of lesions on the ear that successively involves hyper - keratosis ( flaking ) , thickening an... | basaloid skin tumors , including basal cell carcinoma ( bcc ) and basaloid follicular hamartoma ( bfh ) , are associated with aberrant hedgehog ( hh ) signaling1 and , in the case of bcc , an expanding set of genetic variants including keratin 5 ( k5)2 , an intermediate filament - forming protein .
we show that genet... |
most vertebrates are unable to grow and reach their normal adult form without the thyroid hormone [ 1 , 2 ] .
however , various subsequent studies revealed that thyroid hormone plays a key role in rat testis development [ 47 ] .
mammalian testis is a target of thyroid hormone action and altered thyroid function whi... | altered thyroid function during early stages of development is known to affect adversely testicular growth , physiology , and antioxidant defence status at adulthood .
the objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their... |
ewing 's sarcoma family of tumors are a group of small round - cell neoplasms , which include ewing 's sarcoma ( ews ) , primitive neuroectodermal tumor ( pnet ) , askins tumor , pnet of the bone , and extraosseous ewing 's sarcoma ( ess ) .
ewing 's sarcoma / peripheral primitive neuroectodermal tumor , presumed to ... | ewing 's sarcoma / peripheral primitive neuroectodermal tumors occur most often in bone and soft tissues of children and young adults .
the intracranial manifestation of the disease is rare , and when present , this is often misdiagnosed with other varieties of primary brain tumors .
we report such a case of extrao... |
nitric oxide ( no ) is known to have several important vasculo - protective effects ( el - mas et al 1997 ; grdal et al 2005 ) . reduced production of no may lead to atherosclerosis ( lscher and vanhoutte 1990 ; harrison 1997 ; shimokawa 1999 ) .
the synthesis of no from the amino acid , l - arginine , is catalysed b... | we recruited 560 unrelated patients with ischemic stroke and 153 unrelated controls to undertake a genetic analysis for association between the nos3 gene and ischemic stroke .
all the subjects were chinese of han descent . because the nos3 gene spans about 21 kb of dna and contains 26 exons , we selected a single nuc... |
it is located at the interface of these two vastly different environments , and thus is charged with making the final decision about what , from an uncontrolled and often hostile chemical surround , should be incorporated into the highly controlled biochemical environment within .
taste is the beginning of a long che... | taste is the final arbiter of which chemicals from the environment will be admitted to the body .
the action of swallowing a substance leads to a physiological consequence of which the taste system should be informed .
accordingly , taste neurons in the central nervous system are closely allied with those that rece... |
a 36-year - old man visited the emergency department of inje university haeundae paik hospital with severe pain in both lower limbs for 1 day . a physical examination revealed pale , pulseless , and cold lower limbs .
one year ago , he had been diagnosed with kimura disease ( kd ) after excision of a right upper limb... | kimura disease ( kd ) is an immune - mediated chronic inflammatory disease of unknown etiology .
kd has many complications associated with hypereosinophilia , including various forms of allergic reactions and eosinophilic lung disease .
additionally , hypereosinophilia is associated with hypercoagulability , which ... |
businesses offering goods and services to consumers often request feedback from former customers to assess strengths and weaknesses and to leverage positive feedback and testimonials as marketing materials . as these testimonials become more digitized and more public on sites like yelp , facebook , and google+ , busine... | objective .
the primary objective of this investigation is to determine which individual and aggregate factors of residential addiction treatment centers are most significant influencers of alumni satisfaction .
design .
survey targeted alumni of residential addiction treatment facilities .
alumni were queried ... |
the majority of japanese patients with type 2 diabetes mellitus are not obese , as reported by kosaka and ogata more than 50 years ago .
eastern asian subjects might share common characteristics of the disease , comparable to those reported in korean people .
it is , therefore , debatable whether we can apply epide... | aims . we analyzed the prevalence of nephropathy according to past body weight status in japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain
. methods .
we examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus accordin... |
monoamine oxidases ( mao ) are mitochondrial enzymes responsible for the metabolic breakdown of monoamines ( serotonin , norepinephrine , and dopamine ) in neuronal tissues causing depletion of monoamines and clinical depression ; while mao inhibitors ( maois ) result in the clinical improvement of mood states .
inte... | linezolid is a synthetic antimicrobial agent of the oxazolidinone class with weak , nonspecific inhibitor of monoamine oxidase enzymes .
concomitant therapy with an adrenergic or serotonergic agent or consuming tyramine ( > 100 mg / day ) may induce serotonin syndrome ( ss ) .
we present a case report of near - fat... |
aerobic ammonia oxidation , the first and rate - limiting step in nitrification , is the only biological process converting reduced to oxidized inorganic nitrogen species on earth . for over 100 years ,
this process was thought to be mediated by autotrophic beta - proteobacteria and gamma - proteobacteria ( aob ) o... | thaumarchaeota range among the most abundant archaea on earth .
initially classified as
mesophilic crenarchaeota , comparative genomics has recently revealed that they form a separate and deep - branching phylum within the archaea .
this novel phylum comprises in 16s rrna gene trees not only all known archaeal am... |
chronic obstructive pulmonary disease ( copd ) is a chronic respiratory disease characterized by a progressive decline in lung function and accompanied by respiratory symptoms , primarily dyspnea , cough , and sputum production.1,2 given the progressive nature of the disease , the aim of treatments is to reduce symptom... | purposein the absence of head - to - head clinical trials comparing the once - daily , long - acting beta2-agonists olodaterol and indacaterol for the treatment of chronic obstructive pulmonary disease ( copd ) , an indirect treatment comparison by systematic review and synthesis of the available clinical evidence was ... |
diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion , insulin action , or both ( 1 ) .
the chronic hyperglycemia of diabetes is associated with long - term damage , dysfunction , and failure of different organs , especially of eyes , kidneys , nerves , ... | introduction : diabetes is a group of metabolic diseases characterized by hyperglycemia , and represents a disease of the modern age , disease of the 21st century .
prevention of this disease is listed as imperative .
aim of this article was to evaluate questionnaires on the assessment of risk factors for diabetes ... |
acute right heart syndrome ( arhs ) may be defined as sudden deterioration in the right ventricular ( rv ) function and failure of the rv of the heart to deliver adequate blood flow to the pulmonary circulation , resulting in systemic hypoperfusion . in the context of critical illness
evidence of central venous press... | acute right heart syndrome is a sudden deterioration in right ventricular performance , resulting in right ventricular failure and confers significant in - hospital morbidity and mortality . in critically ill patients , the syndrome is often undiagnosed and untreated , as these patients do not usually exhibit the commo... |
in rare conditions , bacteria from carbuncles can spread into the bloodstream and migrate to other areas of the body , causing serious complications such as septicemia and infections in the liver , bones , joints , heart , and central nervous system .
we describe an original case of forehead carbuncle with intractabl... | although carbuncles are commonly seen and may heal on their own or respond well to treatment , in rare conditions , bacteria from carbuncles can spread into the bloodstream and migrate to other areas of the body .
herein , we report on an elderly female who suffered from forehead carbuncle with intractable headache ,... |
hydroxyl radicals , generated by cellular
oxidative stress and inflammation , damage nucleobases or deoxyribose sugars , or both
in dna . at 2-deoxyguanosines ,
hydroxyl radical - mediated hydrogen abstraction at the deoxyribose
c5-position followed by attack at the guanine c8 carbon forms
an n7-centered radi... | diastereomeric 8,5-cyclopurine 2-deoxynucleosides ,
containing a covalent bond between the deoxyribose and the purine
base , are induced in dna by ionizing radiation .
they are suspected
to play a role in the etiology of neurodegeneration in xeroderma pigmentosum
patients .
if not repaired , the s-8,5-cyclo... |
the collective arrangement of the teeth in function is quite important and has been subjected to a great deal of analysis and discussion over the years . as the mandible moves laterally , the lower posterior teeth leave their centric contact with the upper teeth and travel sideways down a path dictated by the condyles ... | background and aims
this study observed occlusal contacts and their area on the teeth during lateral mandibular movements .
the percentage of each occlusal pattern was determined .
materials and methods
fifty subjects ( male : 27 , female : 23 ) , aged 20 - 29 years , were included in the study .
the criteria... |
zinc deficiency is an important cause of morbidity due to infectious diseases and growth - faltering among young children . increased demand of zinc due to rapid growth and decreased intake of zinc due to inadequate feeding practices predispose preschool children , especially living in communities of low socioeconomic ... | community - based data relating to factors influencing zinc deficiency among preschool children in india are inadequate . data of a large , double - blinded , randomized , controlled zinc - supplementation trial were used for assessing the descriptive epidemiology of zinc deficiency among children aged 635 months ( n=9... |
intradural disc herniation ( idh ) is a rare disease and its incidence is reported as 0.26 - 0.30% of all disc herniations16 ) .
idhs primarily occur as a result of chronic degenerative diseases and rarely occur due to traumatic events1,14 ) .
traumatic lumbar spine lesions usually result in bony fractures and para... | intradural lumbar disc herniation is a rare disease . according to the reports of intradural lumbar disc herniations ,
most cases have developed as a chronic degenerative disc diseases .
traumatic intradural lumbar disc herniations are even rarer .
a 52-year - old man visited our emergency center with numbness in... |
initially , they were considered as metastasis from an occult primary tumor in gonads , but now it is known that they arise either as a consequence of abnormal migration of germ cells during embryogenesis or from a different histogenetic origin .
choriocarcinoma of liver without a detectable primary tumor in gonads ,... | choricarcinoma is a beta human chorionic gonadotrophin secreting neoplasm pertinent to uterus and pregnancy mostly .
it occurs primarily in gonads but rarely in extragonadal sites .
primary hepatic choriocarcinoma is an extremely rare tumor .
most of the reported cases are seen in infants representing metastasis ... |
human ifn-2 ( il-28a ) is a relatively new cytokine , in which the genomic structure resembles that of the il-10 family , but the protein structure is more closely related to type i ifn than to interleukin- ( il- ) 10 [ 1 , 2 ] .
for example , it can induce antiviral activity in cell lines , though the potency is wea... | this study investigated the expression levels of interferon- ( ifn- ) 2 in peripheral blood and tissues .
the results showed that the levels of ifn-2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis ( ar ) and combined rhinitis with asthma ( ar + as ) , which was positively correlated with the leve... |
sodium nitrate ( nano2 ) is one of important environmental toxicants and poses important health risks .
most countries use nano2 as food additive as a source of color and flavor preservation in meat products and this chemical can also be found in water resources .
consumption of nano2 at low levels for long time ca... | sodium nitrate ( nano2 ) widely used as food additive for coloring and preserving meat has been reported to induce oxidative stress and cause histopathologic changes , nitrosative tissue damage , and lipid peroxidation in liver and kidney .
therefore , the present study compared the curative effect of chlorophyll fro... |
placental polyp is a somewhat pedunculated remnant of chorionic tissue retained in the uterine cavity for an indefinite time .
it may result in abnormal uterine bleeding and slightly elevated detectable titers of serum -human chorionic gonadotropin ( hcg ) .
these pedunculated masses of villi are often found within... | placental polyp is retained placental tissue within the endometrial cavity , which forms a nidus for inflammation and bleeding .
there are very few reported cases of the clinical placental polyp . here
, we report a case of 34-year - old g4l3ab1 woman with the chief complaint of intermittent vaginal bleeding since ... |
halogen bonding has emerged in recent
years as an effective alternative
to hydrogen bonding in directing the formation of self - assembling
architectures , with fruitful applications in many chemical and biological systems .
halogen bonding is an electrostatically
driven noncovalent interaction between a halo... | halogen bonding , due to its directionality
and tunable strength ,
is being increasingly utilized in self - assembling materials and crystal
engineering . using density functional theory ( dft ) and molecular mechanics
( opls / cm1ax ) calculations ,
multiply halogen bonded complexes of brominated
imidazole... |
in recent years , the development of an integrated nanotherapeutic system which can allow for an online imaging and deliver targeted therapy has been the subject of interest in clinical oncology .
this emerging nanotechnology has allowed the manipulation of nanoparticles ( nps ) to assume multiple functionalities.14 ... | in this study , we synthesized a multifunctional nanoparticulate system with specific targeting , imaging , and drug delivering functionalities by following a three - step protocol that operates at room temperature and solely in aqueous media .
the synthesis involves the encapsulation of luminescent mn : zns quantum ... |
benign prostatic hyperplasia ( bph ) is found in over half of 60-year - old men and in almost all 80-year - old men who develop bladder outlet obstruction ( boo ) and lower urinary tract symptoms ( luts ) .
boo is the initial pathophysiological change caused by an enlarged adenoma and is followed by detrusor overacti... | purposethe aim of this research was to assess the value of the transitional zone index ( tzi ) and intravesical prostatic protrusion ( ipp ) from transrectal ultrasonography in evaluating the severity and progression of disease by analyzing the relationship between the 2 parameters and symptoms , clinical history , and... |
apert syndrome ( acrocephalosyndactylia ) is a developmental malformation characterized by craniosynostosis , a cone - shaped calvarium ( acrocephaly ) , hypertelorism , midface hypoplasia , pseudo cleft - palate , a parrot beak - shaped nose , pharyngeal attenuation , and syndactyly of the hands and feet.1 - 3 the inh... | the purpose of this report is to present apert syndrome patient by highlighting craniofacial characteristics and orthodontic approach to treatment.the patient , a 16-day - old female and the second child of healthy parents , was admitted to our department with primary complaint of cleft palate .
she had a cone - shap... |
electrostatic potentials and free energies were calculated
with a modified version of the delphi program , adapted to solve the nonlinear
poisson - boltzmann equation for protein - membrane systems .
delphi yields
finite - difference solutions to the poisson - boltzmann equation ( the fdpb
method ) for a ... | the heterotrimeric g protein transducin is a key component of the
vertebrate phototransduction cascade .
transducin is peripherally attached to
membranes of the rod outer segment , where it interacts with other proteins at
the membrane - cytosol interface . however , upon sustained activation by light ,
t... |
, it accounts for the largest number of deaths from malignant neoplasms in women and the third largest number in men .
however , since the recurrence rate of t1 colorectal cancer ( invasion no deeper than the submucosa ) without lymph node metastasis is approximately 1% , the outcome of t1 colorectal cancer is consid... | the patient was a 68-year - old man who was admitted to our hospital with a liver tumor . abdominal ultrasonography and computed tomography revealed a liver tumor 30 mm in diameter . on colonoscopy , a pedunculated tumor with a central depression ( 20 mm in diameter )
was observed in the ascending colon , and this tu... |
the cases were collected from our melanoma database , and 30 patients who were treated from january 2001 to december 2010 were retrospectively reviewed .
medical records were reviewed for demographics , clinical and pathological information , immediate as well as remote postoperative events and outcomes , with a mini... | backgrounda retrospective study was conducted to review the overall survival and treatment outcomes of high grade melanoma in the extremity to explore the clinical features of malignant melanoma of the hand and foot , and the therapeutic efficacies and survival rate after amputation.methodsthe clinical data of 30 patie... |
granulocyte macrophage colony - stimulating factor ( gm - csf ) is a hematopoietic growth factor which was originally recognized as a stimulator for the proliferation of granulocytes and macrophages from bone marrow precursor cells .
it has also been shown to promote the survival and activation of mature myeloid cell... | granulocyte macrophage - colony stimulating factor ( gm - csf ) is a hematopoietic growth factor , which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells . in autoimmune and inflammatory diseases ,
th17 cells have been considered as strong inducers of tissue inflammation .... |
hypertrophic cardiomyopathy ( hcm ) is the most common cause of sudden death in young patients .
whereas especially patients with a nonobstructive form of hcm are thought to stay stable for a long time ; a small distinct subset of patients can develop end stage heart failure , which includes a reduction of systolic f... | abstractwe report the case of a 17yearold female patient with known hypertrophic cardiomyopathy and a wolffparkinsonwhite syndrome .
she came to our department for further evaluation of a new diagnosed dilated cardiomyopathy characterized by an enlargement of the left ventricle and a fall in ejection fraction .
cli... |
bacteriocins are toxins produced by the bacteria to inhibit the growth of similar or closely related bacterial strain(s ) during stress conditions .
they are structurally , functionally , and ecologically diverse , produced by almost all major lineages of eubacteria and archaebacteria .
ribosomal encoded bacterioci... | xenorhabdus nematophila , a gram - negative bacterium belonging to the family enterobacteriaceae is a natural symbiont of a soil nematode from the family steinernematidae . in this study cloning ,
expression , and purification of broad range iron regulated multidomain bacteriocin called xenocin from x. nematophila ( ... |
comet lysis buffer ( 2.5 m sodium chloride , 100 mm edta ( ph 8.0 ) , 1% sarkosyl , 10 mm tris hcl ( ph 8.0 ) , 10% dmso , 10% triton x-100 ) . comet alkali solution ( 0.3 m sodium hydroxide , 1 mm edta ) .
cryopreservation medium ( 50% foetal calf serum [ fcs ] , 10% dmso , 40% dulbecco 's modified eagle 's medium ... | backgroundhydrogen peroxide ( h2o2 ) is a common reactive oxygen intermediate generated by various forms of oxidative stress.aimthe aim of this study was to investigate the dna damage capacity of h2o2 in hepg2 cells.methodscells were treated with h2o2 at concentrations of 25 m or 50 m for 5 min , 30 min , 40 min , 1 h ... |
telemedicine utilization is rising due to the increased availability and decreased cost of communication technology , in parallel with growing recognition of key areas of health care that may benefit from its use .
although phone communication continues to be a common form of patient - provider communication , intern... | telemedicine is an increasingly recognized option for cost - effective management of chronic conditions .
we surveyed sleep clinic patients about their experiences and preferences regarding different forms of telemedicine .
adult sleep clinic patients seen between 2009 and 2011 received a brief survey either by pos... |
chromosome 22q13.3 deletion syndrome is a well - recognized cause of global developmental delay ( gdd ) [ 1 , 2 ] while duplication of the same chromosome is a rare occurrence [ 35 ] .
the presence of both abnormalities in the same family has never been reported , to our knowledge .
we report the presence of 22q13.... | chromosome 22q13.3 deletion syndrome is a well - recognized cause of global developmental delay , while duplication of the same chromosome is a rare occurrence .
the presence of both abnormalities in the same family has never been reported , to our knowledge .
we report a rare occurrence of 22q13.3 duplication and ... |
in this study , we retrospectively selected 75 cases of formalin - fixed , paraffin - embedded hair - bearing adult skin samples between 2002 and 2009 at asan medical center .
samples were taken from the margins of routine surgical procedures such as excisional biopsy or excision for benign / malignant skin lesions t... | backgroundcd99 is a cell surface transmembrane glycoprotein expressed in various tissues .
cd99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells .
however , there has been no comprehensive study of cd99 expression in normal skin .... |
glaucoma remains the third or fourth most common cause of blindness in different regions around the globe .
since this is a treatable disease , early diagnosis and adequate follow - up are gaining importance .
also , direct and indirect economic burdens tend to increase for governments with patients extended lifeti... | purpose . to compare two different spectral - domain optical coherence tomography ( oct ) systems in regard to full macular thickness ( mt ) and ganglion cell layer - inner plexiform layer ( gcipl ) measures and in regard to structure - function correlation when compared to standard automated perimetry ( sap ) . method... |
in order to introduce a new plant variety to the markets commercially , it is necessary to register a newly bred variety , which relies upon the results of dus ( distinctness , uniformity , and stability ) tests ; that is , for a new genotype to be registered as a commercial variety , it needs to be distinct ( d ) from... | identification and registration of new rice varieties are very important to be free from environmental effects and using molecular markers that are more reliable .
the objectives of this study were , first , the identification and distinction of 40 rice varieties consisting of local varieties of iran , improved varie... |
sequence - defined biopolymers ,
such as proteins and nucleic acids ,
incorporate backbone and side - chain constituents that endow these
macromolecules with the ability to fold into well - defined secondary
and tertiary structures .
the complexity and functionality of these
folded biopolymers has spurred i... | peptoids are a family of synthetic
oligomers composed of n - substituted
glycine units . along with other
foldamer
systems ,
peptoid oligomer sequences can be predictably designed to form a variety
of stable secondary structures .
it is not yet evident if foldamer
design can be extended to reliably crea... |
malaria remains a serious global health problem , killing more than one million people per year .
the number of malaria cases has fallen by more than 50% in 43 countries over the past decade . a modeling analysis of malaria prevention activities in 34 african countries suggested that about 730,000 lives were saved be... | globalization and urbanization with their inherent developmental activities and ecological transformations impact on malaria epidemiology .
entomological factors involved in malaria transmission in periurban lusaka were assessed prior to vector control reintroduction .
data was collected through standard entomologi... |
hydrocephalus refers to the accumulation of excessive cerebrospinal fluid ( csf ) within the brain or cranial vault .
medical treatment of hydrocephalus , which aims to reduce csf production , is usually only palliative .
surgical shunting of csf from the ventricular system to another body cavity , usually the peri... | case summary ventriculoperitoneal shunt placement is the most commonly utilised surgical treatment for hydrocephalus in human and veterinary patients .
migration of the peritoneal catheter is an uncommon but well - documented complication in people , usually occurring within the first 3 months postoperatively , altho... |
between 25% and 30% of non - small cell lung cancer ( nsclc ) patients will develop metastatic disease in the brain ( brain metastases from non - small cell lung cancer
frequently they are the first site of recurrence in early - stage nsclc patients treated with definitive therapies [ 15 ] .
the prognosis is poor f... | in the systemic treatment of brain metastases from non - small cell lung cancer ( bmf - nsclc ) chemo- and targeted therapy are used .
response rates after platinum - based chemotherapy , range from 23% to 45% .
development of epidermal growth factor receptor tyrosine kinase inhibitors ( egfr - tkis ) : gefitinib o... |
many organs can be herniated into the scrotum such as small intestine , appendix , colon , and ovaries .
ureteral herniation is extremely rare , usually asymptomatic and is reported as isolated case report or small series .
we report the case of an 88-year - old man treated for inguinoscrotal hernia where the left ... | an inguinoscrotal hernia is a common disorder that usually contains intraperitoneal organs ( small intestine , colon , appendix , ovaries ) .
extraperitoneal ureteral herniation into an inguinoscrotal hernia is a rare condition and often associated with congenital abnormalities or postoperative anatomic changes .
a... |
in the closed structure of the p2x cation channel , three -helical transmembrane domains cross the membrane obliquely : in rat p2x2 receptors , these intersect at thr339 . replacing thr339 by lysine in one , two or three subunits progressively increased chloride permeability and reduced unitary conductance .
this imp... | |
the incidence of non - hodgkin lymphoma ( nhl ) is 100200-fold higher in hiv - infected individuals than in the general population .
nhl is an aids - defining illness and in 35% of cases , the lymphoma is the initial manifestation of aids .
the most common hiv - associated lymphomas are diffuse large b cell lymphom... | primary mediastinal large b cell lymphoma ( pmlbcl ) is a subtype of diffuse large b cell lymphoma arising in the mediastinum with distinctive clinical and morphological features .
though diffuse large b cell lymphoma is one of the most common non - hodgkin lymphoma associated with aids , there are no data available ... |
cardiovascular disease ( cvd ) is the main cause of death in maintenance hemodialysis ( mhd ) patients .
both aortic artery calcification ( aac ) and cardiac valve calcification ( cvc ) have a high incidence in dialysis patients .
the diagnosis of vascular calcification is usually based on very expensive and highly... | background : this study was to investigate the relationship among aortic artery calcification ( aac ) , cardiac valve calcification ( cvc ) , and mortality in maintenance hemodialysis ( mhd ) patients.methods:all mhd patients in shanghai ruijin hospital in july 2011 were included . to follow up for 42 months , clinical... |
in an era of finite resources and ever - increasing medical possibilities , every health care system faces challenges in determining which new health technologies , including medical devices , should be introduced into clinical practice.1 while technology can improve safety2 and have other benefits , it can also bring ... | purposeintroducing new health technologies , including medical devices , into a local setting in a safe , effective , and transparent manner is a complex process , involving many disciplines and players within an organization .
decision making should be systematic , consistent , and transparent .
it should involve ... |
in anterior cruciate ligament ( acl ) reconstruction , the use of bone patellar tendon bone graft ( bptb ) has been decreasing due to increased anterior knee pain , weakness of extensor power and difficulty of kneeling position . instead , the use of hamstring tendon has been increasing1,2 ) ; however , the disadvantag... | purposethis study evaluated mid - term results of anterior cruciate ligament ( acl ) reconstruction using the pinn - acl crosspin system that allowed for short graft fixation.materials and methodsforty - three patients underwent single - bundle acl reconstruction with a 4-strand semitendinosus tendon graft using the pi... |
autosomal - recessive renal tubular dysgenesis ( ar - rtd ) is a rare inherited disorder caused by mutations in the genes encoding any of the components of the renin
angiotensin system ( ras ) including renin , angiotensinogen , angiotensin - converting enzyme ( ace ) and type 1 angiotensin ii receptor .
fetuses ma... | autosomal - recessive renal tubular dysgenesis ( ar - rtd ) is a rare disorder caused by a genetic defect in the renin
angiotensin system .
although ar - rtd has typically been known as a lethal disease due to refractory hypotension and renal failure immediately after birth , few cases have reported survival of the... |
patients with ibd should be periodically examined regarding their dermatologic conditions . in a previous report from iran ,
the prevalence of dermatological manifestations was reported to be 5.9% in patients with ibd with a higher rate in crohn s disease ( 7.29% ) compared with patients with ulcerative colitis ( 4.0... | some dermatologic manifestations are common in ulcerative colitis ( uc ) . herein , we present a 36-year - old woman with ulcerative colitis and uncommon nasal mucosa pyoderma vegetans .
the patient presented to our hospital with symptoms of active colitis and a concomitant 345 cm dermato - mucosal lesion in her left... |
sepsis is the main cause of mortality in pediatric intensive care units ( picus ) .
it is caused by numerous infectious agents , inducing multiple organ dysfunction syndrome ( mods ) , multiple organ failure ( mof ) , and even death .
several studies have demonstrated that the severity of sepsis , as well as early ... | backgroundto investigate the prognostic value of procalcitonin ( pct ) , high - sensitivity c - reactive protein ( hs - crp ) , and pancreatic stone protein ( psp ) in children with sepsis.material/methodsa total of 214 patients with sepsis during hospitalization were enrolled .
serum levels of pct , hs - crp , and p... |
rna can play an important functional role in catalysis , e.g. ribozymes are rna enzymes that cleave rna phosphodiester bonds at specific sites ( 1 ) ; see ( 2 ) for an overview of potential therapeutic applications of ribozymes to cleave mrnas of oncogenes ( ras or bcr - abl ) and viral transcripts ( hiv-1 ) , to overc... | rnaomics , analogous to proteomics , concerns aspects of the secondary and tertiary structure , folding pathway , kinetics , comparison , function and regulation of all rna in a living organism . given recently discovered roles played by micro rna , small interfering rna , riboswitches , ribozymes , etc . , it is impor... |
central neuropathic pain ( central pain ) is pain caused by a disease or lesion in the central nervous system .
central pain develops in about 8% of stroke patients ( andersen et al 1995 ) , 25% of patients with multiple sclerosis ( osterberg et al 2005 ) , and 40%50% of patients with spinal cord injury ( budh et al ... | central neuropathic pain ( central pain ) is treated with antidepressants , various anticonvulsants , opioids , and cannabinoids , but in many cases treatment is insufficient and associated with a range of side - effects .
this review addresses a new treatment for neuropathic pain , the anticonvulsant pregabalin .
... |
toxic cyanobacterial blooms in eutrophic lakes , ponds , and reservoirs are a common occurrence around the world [ 13 ] .
cyanobacteria of the genera microcystis , anabaena , nostoc , and planktothrix produces a wide range of potent toxins , including a family of heptapeptide hepatotoxins , referred to as microcystin... | for the first time a microcystin - degrading bacterium ( nv-3 isolate ) has been isolated and characterized from a nz lake .
cyanobacterial blooms in new zealand ( nz ) waters contain microcystin ( mc ) hepatotoxins at concentrations which are a risk to animal and human health .
degradation of mcs by naturally occu... |
pancreatic heterotopia is defined as the presence , outside its usual location , of pancreatic tissue which lacks anatomical and vascular continuity with the pancreas proper ( 1 ) .
the heterotopic pancreas ( hp ) is a relatively uncommon congenital anomaly , with an incidence between 0.55% and 13.7% in autopsy serie... | heterotopic , aberrant or ectopic pancreas is defined as the presence of pancreatic tissue in topographic anomaly , with no anatomical , neural or vascular connection to the normal pancreas . it is a rare condition found mainly in stomach , duodenum and jejunum .
ileal heterotopic pancreas is an uncommon condition an... |
cytomegalovirus ( cmv ) infection still remains a major cause of morbidity and mortality in allogeneic stem cell transplantation ( sct ) recipients .
while cmv infection of the central nervous system ( cns ) in acquired immune deficiency syndrome patients has been reported relatively frequently , it is an unusual pre... | despite the prophylaxis and preemptive strategies using potent antiviral agents , cytomegalovirus ( cmv ) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation ( sct ) recipients . delayed immune reconstitution after sct , such as cord blood and t - cell depleted sct with t... |
lateral gene transfer ( lgt ) is a phenomenon central to prokaryotic evolution and adaptation . with the increasing use and sophistication of genomics technologies and bioinformatics tools , estimates of the extent of laterally transferred genes
a recent study estimated that an average of 81% of the genes in any give... | lateral gene transfer ( lgt ) impacts on the evolution of prokaryotes in both the short and long - term .
the short - term impacts of mobilized genes are a concern to humans since lgt explains the global rise of multi drug resistant pathogens seen in the past 70 years .
however , lgt has been a feature of prokaryot... |
diabetes mellitus ( dm ) is a clinical syndrome characterized by hyperglycemia because of absolute or relative deficiency of insulin . the diagnosis of dm is based on blood glucose estimations .
blood collection is an invasive procedure , and may be traumatizing , especially in diabetic patients who require routine d... | aims and objectives : the purpose of this study was to estimate and assess any correlation between random capillary blood glucose ( rcbg ) and unstimulated whole salivary glucose ( uwsg ) , as well as to estimate various salivary parameters , such as flow rate , ph , buffering capacity , and the influence of these fact... |
due to increasing life expectancy of the dentition , older adults are experiencing root caries and gingival recession , putting them at even higher risk for periodontal disease .
root caries is the major cause of tooth loss in older adults , and tooth loss is the most significant oral health - related negative variab... | root caries is one of the most significant dental problems among older adults today .
many studies have demonstrated that older adults are at greater risk for developing root caries .
here we examine what risk factors older adults are prone to and explain how they contribute to higher rates of oral disease , in par... |
overweight and obesity is an increasing problem globally . the prevalence is often estimated by body mass index ( bmi ; weight in kg divided by squared height in meters ) . in epidemiological surveys , height and weight are often gathered using self - report questionnaires .
this type of data collection is advantageo... | backgroundbody mass index ( bmi ) based on self - reported height and weight has been criticized as being biased because of an observed tendency for overweight and obese people to overestimate height and underestimate weight , resulting in higher misclassification for these groups .
we examined the validity of bmi ba... |
the functions of the salivary glands are controlled by the autonomic nervous system and influenced by the sensory nervous system .
when parasympathetic impulses dominate , salivary flow is greatly enhanced and the saliva has a low protein content .
studies of animal and human innervation have revealed that parasymp... | cevimeline is a novel muscarinic acetylcholine receptor agonist currently being developed as a therapeutic agent for xerostomia .
we examined the effects of cevimeline on salivary and plasma levels of substance - p- ( sp- ) , calcitonin - gene - related - peptide- ( cgrp- ) , and vasoactive - intestinal - polypeptide... |
the technique of lymphatic mapping and sentinel lymph node biopsy ( slnb ) has emerged in the last two decades as a minimally invasive approach to evaluate regional lymph node basins in patients with intermediate and high - risk primary cutaneous melanoma . in particular , slnb is now recommended as a staging procedure... | the american society of clinical oncology guidelines recommend sentinel lymph node biopsy ( slnb ) for all patients with melanoma tumors of intermediate thickness ( between 1 and 4 mm ) . in case of patients with thick melanoma tumors ( > 4 mm ) , slnb may be recommended as well , for staging purposes and to facilitate... |
the chronic diseases like cardiovascular diseases , diabetes and cancer contributes to almost half of the all - cause mortality in india . weighted prevalence of ischemic heart diseases was observed as 25.3/1000 population , and 118.0/1000 population for diabetes mellitus in an urban area of india .
it was observed d... | since a very long time , a significant number of patients have been seeking treatment at complementary and alternative medicine health facilities , but the disease burden at these facilities has never been assessed and documented .
present cross - sectional study was carried out at ayurvedic tertiary care hospital to... |
proinflammatory cytokines ( il-1 , il-6 , and tnf- ) may significantly influence the development of obesity and concomitant disorders such as type 2 diabetes , arterial hypertension and metabolic disorders .
it is suggested , that il-6 may affect the increase of free fatty acids level .
tnf- is secreted mainly by m... | backgroundthe development of obesity and related disorders , e.g. , type ii diabetes ( t2d ) , hypertension , and metabolic disturbances is strongly related to increased levels in proinflammatory cytokines ( il-1 , il-6 , and tnf- ) . both il-6 and tnf-
are secreted by adipocytes and their concentration correlates wi... |
the empa - reg outcome trial ( clinicaltrials.gov identifier , nct01131676 ) recently announced the effects of empagliflozin on the cardiovascular outcomes ( cvo ) and mortality in persons with type 2 diabetes mellitus ( t2 dm ) . in this seminal cvo trial ( cvot ) , 7020 patients with t2 dm with coexisting cardiovascu... | this article discusses the recently published empa - reg outcome trial , which assessed cardiovascular outcomes with empagliflozin therapy in persons with type 2 diabetes mellitus and coexisting cardiovascular disease .
the article describes the background and challenges of modern cardiovascular outcome trials , poin... |
primary neuroendocrine carcinoma ( nec ) of the breast is a rare distinct clinicopathological entity , comprising 0.5 - 2% of breast carcinomas world - wide . in 2003 ,
primary nec of the breast was identified as a distinct entity by the world health organization ( who ) classification of tumors .
the who classific... | cases of primary neuroendocrine carcinoma ( nec ) of the breast have been reported , though rare .
we report the case of a 45-year - old woman presented with jaundice and evaluated to have liver metastasis from neuroendocrine origin .
she underwent whole body positron emission tomography / computed tomography , whi... |
malignant unilateral or bilateral ureteral obstruction may be secondary to direct tumor invasion , extrinsic compression , or encasement by metastatic retroperitoneal or pelvic lymph nodes .
the selection of cancer patients for diversion should take into account factors such as tumor stage , prognosis of the primary ... | purposewe assessed the efficacy and safety of insertion of a polytetrafluoroethylene membrane - covered self - expandable metallic stent ( uventa stent ) for palliation of malignant ureteral obstruction on the basis of our early results.materials and methodseighteen patients underwent uventa stent insertion for extrins... |
typically , using standard assessment criteria , approximately 50 to 100 channel targets are detected in chondrocytes .
not surprisingly the dataset from each study are rather different to each other , but there is a common set of 7 probes that are detected in all 10 of these studies .
it is important to note that ... | to date , a range of ion channels have been identified in chondrocytes using a number of different techniques , predominantly electrophysiological and/or biomolecular ; each of these has its advantages and disadvantages .
here we aim to compare and contrast the data available from biophysical and microarray experimen... |
chronic obstructive pulmonary disease ( copd ) is characterized by progressive and partially reversible airflow limitation , and it is among the leading causes of mortality worldwide.1 copd is a multicomponent disease , and patients present a range of comorbidities that have an impact on prognosis and may increase the ... | purposewe investigated the association between cognitive impairment and chronic obstructive pulmonary disease ( copd ) , taking into account demographic and clinical variables evaluated during routine practice.patients and methodswe performed a post hoc analysis of a cross - sectional study that included subjects with ... |
intestinal helminths are among the most common and widespread of human infections , contributing to poor nutritional status , anemia and impaired growth ( 1 ) .
intestinal helminthiases are also known to aggravate pre - existing anemia by decreasing appetite and thus food and iron intake ( 2 , 3 ) .
worldwide , an... | backgroundthe incidence and hematological effects of helminth infection during pregnancy were investigated among pregnant women in isiala , mbano , southeast nigeria.methods:totally 282 pregnant women were enlisted for the study between october 2011 and september 2012 .
stool samples were examined for intestinal helm... |
soft tissue sarcomas are very rare tumors ; however , there are many histologic subtypes . among those subtypes ,
furthermore , among sarcomas originating within the retroperitoneum , which constitute 1015% of all soft tissue sarcomas , liposarcomas are the most common histologic type , accounting for 41% of these tu... | retroperitoneal liposarcoma is a rare tumor .
the dimension and weight of liposarcoma are variable ; those over 20 kg are called
giant liposarcoma. herein , we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures... |
eight members with schwannomatosis from four consecutive generations of a family included in this study were selected according to the following criteria : age : > 30 years ; two or more nonintradermal schwannomas , at least one with histological confirmation ; no evidence of vestibular tumor on high - quality magnetic... | purpose : schwannomatosis , a subtype of neurofibromatosis , is characterized by multiple benign , nonvestibular , nonintradermal schwannomas .
although the tumor suppressor smarcb1 gene has been frequently identified as the underlying genetic cause of half of familial and ~10% of sporadic schwannomatosis , for most ... |
emergence of bacterial resistance to many different antibiotics is considered as a great concern in human health .
pseudomonas aeruginosa ( pa ) has been recognized as one of the significant pathogens of nosocomial infections ( 1 ) .
key mechanism of antibiotic resistance in p. aeruginosa is the expulsion of antibi... | background and objectives : pseudomonas aeruginosa ( pa ) is one of the most important causes of nosocomial infections and has an intrinsic resistance to many antibiotics . among all the resistance - nodulation - division ( rnd )
pumps of p. aeruginosa , mexab - oprm is the first efflux pump found to target multiple ... |
severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit ( icu ) setting .
the endotoxin ( lipopolysaccharide [ lps ] ) derived from the outer membranes of gram - negative bacteria is considered a major factor in the pathogenesis of sepsis .
the toll - like receptor ( tl... | background and aims : severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit setting .
endotoxin , derived from the outer membranes of gram - negative bacteria , is considered a major factor in the pathogenesis of sepsis .
this study investigated the effect of alteco e... |
a recent report published by the american association of colleges of nursing ( aacn ) noted that over 67,000 qualified applicants were not accepted into baccalaureate and graduate nursing programs in the usa in 2010 .
the report also noted that almost two - thirds of the nursing schools participating in the survey no... | the shortage of nursing faculty has contributed greatly to the nursing workforce shortage , with many schools turning away qualified applicants because there are not enough faculty to teach . despite the faculty shortage , schools are required to admit more students to alleviate the nursing shortage .
clinical groups... |
ameloblastoma is seen to have a benign appearance on histology , irrespective of its variable clinical behavior .
microscopically various patterns have been described ( follicular , plexiform , acanthomatous , papilliferous - keratotic , granular cell type , desmoplastic , vascular , and dentinoameloblastoma).[13 ] m... | ameloblastoma is a slow growing odontogenic epithelial tumor of jaw .
it accounts for 1% of all tumors and cysts arising in maxilla and mandible .
although it is locally invasive and has a marked tendency to recur , metastasis is rare . of the various histological patterns of ameloblastoma ,
the granular cell typ... |
mesenteric and omental mesothelial cysts are responsible for only 1 in 100,000 of adult hospital admissions , and are thus left low on the list of differential diagnoses for abdominal pain .
further evaluation of such masses is first directed at determining a tissue origin if possible .
lymphangioma accounts for th... | highlightsmesenteric cystic masses account for a very small fraction of abdominal pain cases.symptoms arise likely as a result of mass effect , even when these lesions are small.on detection of these lesions by imaging , it is important to exclude neuroendocrine tumors.complete surgical excision is curative of symptoms... |
in the past , a number of studies1,2 have given insight into the epidemiology of primary open - angle glaucoma .
for caucasians , it is estimated that almost 2% of the population will suffer from the disease , and for afro - caribbeans this percentage goes to almost 8% . according to the world health organization , a... | the purpose of our systematic review is to document the adverse events that follow phacoemulsification in eyes with trabeculectomy due to glaucoma and to determine whether phacoemulsification jeopardizes the survival of the trabeculectomy .
our research was based on english- and non - english - language articles obta... |
in the united states , 166 million dental restorations were placed in 2005,1 and clinical studies suggest that more than half were replacements for
failed restorations.2 it is anticipated that the
emphasis on replacement therapy will increase with the phasing out of dental amalgam .
global
concerns regarding me... | restoring posterior teeth with resin - based composite materials continues to gain popularity among
clinicians , and the demand for such aesthetic restorations is increasing . indeed , the most common
aesthetic alternative to dental amalgam is resin composite .
moderate to large posterior composite
restorations... |
sarcoidosis is a rare condition with a prevalence of 4.46.3 patients per 100,000 personyears in australia , a figure similar to that of the united state 1 , 2 .
it is a multisystem granulomatous disorder of unknown etiology predominantly affecting young and middleaged adults 3 , 4 .
diagnostic criteria are based on... | key clinical messagesarcoidosis is a diagnosis that should be considered in patients receiving interferon therapy , who present with anemia and multiorgan dysfunction regardless of the duration of their treatment . when sarcoidosis is suspected , bone marrow biopsy should be considered especially for cases predominant ... |
apratoxins are potent
cytotoxins derived from marine cyanobacteria . because of their biological activity and intriguing
structures ,
we recently established that
apratoxins prevent cotranslational translocation and thereby downregulate
various receptors , including receptor tyrosine kinases ( rtks ) , and
... | apratoxins
are cytotoxic natural products originally isolated from
marine cyanobacteria that act by preventing cotranslational translocation
early in the secretory pathway to downregulate receptor levels and
inhibit growth factor secretion , leading to potent antiproliferative
activity . through rational desi... |
seizure in patients with systemic lupus erythematosus ( sle ) is considered to be one of the major manifestations of the disease .
the prevalence of seizure has been documented as about 10 to 20% in the patients with sle ( 1 , 2 ) .
this neuropsychiatric event is likely to be primary to the sle or secondary due to ... | a 51-yr - old female was referred to our outpatient clinic for the evaluation of generalized edema .
she had been diagnosed with idiopathic thrombocytopenic purpura ( itp ) .
she had taken no medicine . except for the itp , she had no history of systemic disease .
she was diagnosed with systemic lupus erythematos... |
stress urinary incontinence ( sui ) , pelvic organ prolapse , and chronic pelvic pain are frequent complaints of women in perimenopause and menopause and result mainly from pelvic floor insufficiency .
proper statics of the pelvic floor provides adequate support for the urethra and bladder , which determines the corr... | objectivesin physiotherapeutic practice , special attention is being given to the reciprocal anatomical , physiological , and biomechanical relationship of the pelvis and the structures connected to it .
however , the scientific literature shows mainly the theoretical information about their mutual connections .
th... |
thermal spring 's microbiomes have been in attention of the scientific community since past few decades .
these springs , being hub of diverse microflora , increase the probability of vast gene pool of uncultured microbiota .
metagenomics have helped the microbiologist to reveal the genome of the rest of the 99%... | insights about the distribution of the microbial community prove to be the major goal of understanding microbial ecology which remains to be fully deciphered .
hot springs being hub for the thermophilic microbiota attract the attention of the microbiologists .
deulajhari hot spring cluster is located in the angul d... |
an article recently published demonstrated the efficacy of eculizumab in the treatment of children with severe hematopoietic stem cell transplantation - associated thrombotic micro - angiopathy ( hsct - tma ) .
we report the case of an adult with hsct - tma successfully treated with eculizumab .
hsct - tma is a rar... | a 30-year - old man with acquired aplastic anemia underwent an hla - identical bone marrow transplant .
he developed a grade iii acute graft versus host disease ( gvhd ) refractory to various lines of treatment .
on post - transplant day 196 , he was diagnosed with stem cell transplantation - associated thrombotic ... |
numerous medical conditions are known to produce psychotic symptoms that resemble schizophrenia , including metabolic and neurological disorders ( cummings 1996 ) .
we describe a young woman with schizophrenia - like psychotic symptoms and functional decline in the context of diagnosed aceruloplasminemia , a disorder... | schizophrenia - like illnesses occur in a variety of medical and neurological conditions but to date have not been described in association with aceruloplasminemia .
aceruloplasminemia is an autosomal recessive disorder of iron metabolism which leads to iron deposition in the basal ganglia , thalamus , cerebellum and... |
we screened
a collection of sponge- and marine fungi - derived extracts
( n = 2500 ) and pure compounds ( n = 400 ) using a primary cell - based in vitro model of hiv-1 latency
that is re - engineered for optimal sensitivity and miniaturized for
high - throughput screening .
two hits were initially
given hi... | an extract of humicola fuscoatra ( ucsc strain
no .
108111a ) was shown to reactivate latent hiv-1 expression in an
in vitro model of central memory cd4 + t cells .
we report the bioassay - guided
isolation and structure determination of several resorcyclic acid
lactones , including four known compounds , r... |
warfarin is highly effective in reducing stroke risk in patients with atrial fibrillation ( af ) .
however , using warfarin is not easy ; effort is needed to educate patients about drug and dietary interactions , and serial monitoring of the international normalization ratio ( inr ) is required . as a result ,
a re... | atrial fibrillation ( af ) is an emerging epidemic in both high - income and low - income countries , mainly because of global population aging .
stroke is a major complication of af , and af - related ischemic stroke is more disabling and more fatal than other types of ischemic stroke .
however , because of concer... |
the author has not received any funding or benefits from industry or elsewhere to conduct this study . | there remain tremendous opportunities to improve the stability and safety of american health care . within this context ,
residents and residency programs face two essential questions : how to reduce the risk to patients resulting from resident inexperience , and how to change our programs to create the safer physici... |
attention to women 's health has evolved from a limited focus on reproductive and breast health to encompassing all aspects of health from birth through old age . in the era of individualized and precision medicine , innovative medical , surgical , pharmacological , regenerative , and genetic technologies are available... | abstractthe national institutes of health 's ( nih ) commitment to improving health outcomes for women and men through rigorous science has been compromised by the lack of basic science evidence obtained from female animals . to correct this limitation , in june 2015
the nih announced expectations that sex , as a b... |
thymic neuroendocrine ( ne ) tumors associated with multiple endocrine neoplasia type 1 ( men-1 ) are rare , variably documented in 1 - 8% cases .
thymic ne tumors are usually detected about 7 - 29 years following surgical treatment of primary hyperparathyroidism ( phpt ) in men-1 .
transcervical thymectomy ( tct )... | thymic neuroendocrine ( ne ) tumors are a rare manifestation of multiple endocrine neoplasia syndrome type 1 ( men-1 ) .
they are malignant and aggressive tumors and form a major cause of mortality in men-1 .
transcervical thymectomy ( tct ) at the time of parathyroid surgery for primary hyperparathyroidism ( phpt ... |
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