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despite the development of ever more efficacious and safe pharmacological treatments , cardiovascular diseases are still the leading cause of death and invalidity in the developed countries , and in most of the so called second world ( 1 ) .
arterial hypertension is one of the most relevant independent cardiovascul... | omega-3 polyunsaturated fatty acids ( pufas ) from fish and fish oils appear to protect against coronary heart disease : their dietary intake is in fact inversely associated to cardiovascular disease morbidity / mortality in population studies .
recent evidence suggests that at least part of their heart protective ef... |
the emerging phenomenon of so - called health tourism has been in europe since the time of ancient greece and rome ( 12 ) . the term health tourism was introduced in 1987 by goodrich ( 3 ) .
this multi - faceted topic has been considered as an academic one , from mid-1990s .
in addition to some books introducing ... | background : the aim of the present study was to appraisal the prose and cone of shiraz city in terms of its potential in the context of health tourism.methods:the statistical sample included medical and health tourism sector in the city of shiraz in the northwest of fars province , south of iran .
the efficient auth... |
the genes involved in the determination of the gonads comprise the wilms ' tumor suppressor gene wt1 , the orphan nuclear receptor sf-1 and the high mobility group family member sox9 ( parker et al . 1999 ) . after determination
, the differentiation of the testis depends on the testis - determining factor sry ( good... | platelet - derived growth factor ( pdgf)- a deficient male mice were found to develop progressive reduction of testicular size , leydig cells loss , and spermatogenic arrest . in normal mice ,
the pdgf - a and pdgf - r expression pattern showed positive cells in the seminiferous epithelium and in interstitial mesenc... |
therapeutic hypothermia instituted within 6 h of birth has been shown to improve neurodevelopmental outcomes in term newborns with moderate to severe hypoxic ischemic encephalopathy ( hie ) .
the majority of infants who would benefit from cooling are born at centers that do not offer the therapy , and adding the ... | objective : therapeutic hypothermia instituted within 6 h of birth has been shown to improve neurodevelopmental outcomes in term newborns with moderate to severe hypoxic
ischemic encephalopathy ( hie ) .
the majority of infants who would benefit from cooling are born at centers that do not offer the therapy , an... |
approximately 20% of lumbar hernias are congenital in nature , while remainder are acquired . congenital lumbar hernia ( clh )
is associated with a multitude of congenital anomalies involving various other organ systems of the body .
less than 50 cases of congenital lumbar hernia associated with other congenital an... | aim .
congenital lumbar hernia is an uncommon anomaly with only few cases reported in the english literature .
this study was done to study the incidence , age at presentation , sex , associated anomalies , surgical management , and postoperative morbidity and mortality of congenital lumbar hernia in pediatric pati... |
lymphoblastic lymphoma ( lbl ) is an aggressive form of non - hodgkin s lymphoma ( nhl ) , comprising approximately 2% of all adult nhl cases .
lbl generally shows a high response rate to initial chemotherapy ; however , relapse is common and overall survival is poor with treatment using conventional lymphoma regimen... | t - lymphoblastic lymphoma ( t - lbl ) is a rare form of aggressive non - hodgkin s lymphoma .
the standard approach for management of t - lbl involves intensive multiagent chemotherapy regimens for induction and consolidation phases with central nervous system prophylaxis and a maintenance phase lasting 12 - 18 mont... |
malaria is a disease of global importance resulting in morbidity and mortality worldwide [ 1 , 2 ] . although , since 2000 a reduction in the mortality rate of about 25% has been globally observed , nearly half of the world 's population is still living at risk of infection [ 1 , 3 ] leading to more than 0.5 million de... | malaria is an infectious disease that results in serious health problems in the countries in which it is endemic . annually
this parasitic disease leads to more than half a million deaths ; most of these are children in africa .
an effective vaccine is not available , and the treatment of the disease is solely depe... |
a 56-year - old male presented with chronic on and off pain in the left eye
his systemic examination revealed multiple subcutaneous tumors in distal upper limbs and more than 6 caf - au - lait macules ; but all were < 15 mm in diameter .
his vision was 20/30 in right eye and counting fingers at 3 feet in left eye .... | primary iridociliary cysts can induce plateau iris configuration and angle closure glaucoma .
we report a patient with bilateral , primary , ring - shaped , solitary iridociliary cysts .
the right eye displayed normal intraocular pressure , oppositional iridocorneal angle closure , and healthy optic nerve head .
... |
the number of end - stage renal disease patients requiring renal replacement therapy is increasing worldwide . in japan
peritoneal dialysis ( pd ) and hemodialysis ( hd ) are the two major dialysis modalities .
the prognosis associated with these modalities is a clinically important issue and has been debated for a... | to examine the relationship between dialysis modality and prognosis in japanese patients , we conducted a prospective multicenter observational study .
we recruited 83 background - matched peritoneal dialysis ( pd ) and 83 hemodialysis ( hd ) patients ( average age , 64.9 years ; men , 53.6% ; diabetic patients , 22.... |
past research and/or salary support : national institute of mental health k23 nimh 5 k23 mh070897 - 02 , role : pi ; nih / ncrr 5 ul1 rr024982 - 02 packer ( pi ) role : pilot study pi ; neuronetics grant - in - kind support for supplies and use of equipment ; the defense academy for credibility assessment ( formerly th... | refinements in the methods of diagnosis for psychiatric disorders are critically needed .
these new methods should be based on objectively measured brain characteristics that provide clinically useful information .
studying the brain with respect to psychiatric disorders , however , faces numerous challenges .
ut... |
if the amplitude of the cnv is related to the value of the temporal accumulator , variations in the cnv should be reflected in timing performance .
( 1999 , experiment 1 ) observed a correlation between the reproduced duration and the cnv amplitude , a finding that has been interpreted as evidence in support of this ... | the relation between the contingent negative variation ( cnv ) and time estimation is evaluated in terms of temporal accumulation and preparation processes .
the conclusion is that the cnv as measured from the electroencephalogram ( eeg ) recorded at fronto - central and parietal - central areas is not a direct refle... |
viruses are important causes of morbidity and mortality in elderly patients , and respiratory viral infections , particularly influenza , remain a significant cause of death in community - dwelling older adults .
influenza vaccination may have limited efficacy in this population , possibly due to age - associated dec... | cvt - e002 ( a proprietary extract ) was found to be effective in the prevention of upper respiratory infections ( uris ) in healthy adults , and institutionalized and community - dwelling seniors .
a multicenter , randomized , double - blind , placebo - controlled trial was carried out to determine effects of cvt - ... |
during 20042007 , serum samples from 1,036 sheep and goats in turkey were serologically screened for infection with pestiviruses of small ruminants .
of these , 11 serum samples from 7 sheep herds gave positive or doubtful reactions in the csfv antibody
specific elisa ( herdchek , idexx ) and were subjected to comm... | to determine why serum from small ruminants infected with ruminant pestiviruses reacted positively to classical swine fever virus ( csfv)specific diagnostic tests , we analyzed 2 pestiviruses from turkey .
they differed genetically and antigenically from known pestivirus species and were closely related to csfv .
c... |
to report on a case that developed an atypical form of occult choroidal neovascularization ( cnv ) after successful macular hole surgery .
visual acuity change , color fundus photographs , fluorescein and indocyanine green angiograms , and optical coherence tomography results were compared throughout the follow - up ... | purposeto report on a case that developed an atypical form of occult choroidal neovascularization ( cnv ) after successful macular hole surgery.methodsvisual acuity change , color fundus photographs , fluorescein and indocyanine green angiograms , and optical coherence tomography results were compared throughout the fo... |
two years previously , a mass involving the left thigh had been diagnosed after wide excision as multiple myeloma and the patient had undergone chemotherapy . after 6 months , the disappearance of serumal monoclonal protein and a free light chain in the urine indicated complete remission .
ugis demonstrated a luminal... | we report a case of multiple myeloma with gastric involvement occurring in a patient who underwent an upper gastrointestinal series ( ugis ) , ct and mri .
ugis depicted a luminal protruding mass , while contrast - enhanced ct demonstrated marked thickening of the gastric wall , with subtle contrast enhancement . at ... |
incarcerated hernia frequently requires emergency surgery since it is associated with intestinal obstruction and ischemia .
however , emergency surgery for intestinal obstruction has a high mortality and morbidity.1,2 recently , we were able to perform elective laparoscopic repair of a morgagni hernia causing obstruc... | plain radiographs of an 88-year - old woman who had experienced vomiting and abdominal distention for 3 days revealed a severely obstructed ileus , and abdominopelvic computed tomography revealed an incarcerated morgagni hernia .
the endoscope was passed through the constrictions from the diaphragmatic indentations a... |
lymphomatoid granulomatosis ( lg ) is a systemic , epstein barr virus ( ebv ) associated , b cell lymphoproliferative disorder with angiocentric / angiodestructive pattern .
lg occurs more frequently in patients with immunosuppressive conditions ( acquired immunodeficiency syndrome , wiskott - aldrich syndrome , and ... | lymphomatoid granulomatosis is a rare systemic angiocentric / angiodestructive , b cell lymphoproliferative disorder .
central nervous system involvement occurs as part of systemic disease .
isolated central nervous system disease is rare with only few case reports . a 53-year - old male presented with progressive ... |
typically , a complex cascade of events follows cutaneous injury aiming to repair the skin in sequential and overlapping phases beginning with an acute inflammatory response , matrix degradation , and tissue remodeling which subsides to the formation of a mature tissue .
adverse wound healing can lead to excessive sc... | directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies .
thus , antifibrotic interfering rna ( rnai ) therapy with exogenous microrna ( mir)-29b was proposed as a method to modulate extracellular matrix remodeling following cutaneous injury .
it was hypothesized that ... |
creating order and
complexity through self - assembly of simple molecular
building blocks is an important area of contemporary science .
yet , it is the external control over the molecular order that brings
about technological disruptions , as well exemplified by the success
of liquid crystals in display indu... | here ,
we present a new family of light - responsive , fluorinated
supramolecular liquid crystals ( lcs ) showing efficient and reversible
light - induced lc - to - isotropic phase transitions . our materials design
is based on fluorinated azobenzenes , where the fluorination serves
to strengthen the noncoval... |
multiple sclerosis ( ms ) is a chronic , autoimmune disease of the central nervous system characterized by demyelination of nerve cells with resultant scarring known as plaques .
it mostly occurs between the ages 20 and 40 and has more prevalence in female than male . in iran ,
fatigue is the most prevalent and dis... | background and aim : the psychological changes and physiological limitations during multiple sclerosis ( ms ) disease diminish the social relations .
consequently , losing social supports leads to more physical and psychological complications such as fatigue syndromes .
therefore , this study aimed to investigate t... |
bruxism is defined as diurnal or nocturnal parafunctional jaw muscle activity that is characterized by clenching , bracing , gnashing , and grinding of teeth .
parafunctions play an important role in oral and general health [ 2 , 3 ] .
muscle pain , headaches , tooth wear , temporomandibular joint disorders , and e... | objectives . the aim of this cross - sectional study was to identify sleeping patterns among dental students and their association with self - reported bruxism in riyadh colleges of dentistry and pharmacy ( rcsdp ) . methods .
a cross - sectional study was performed including 549 students ( 67 men and 482 women ) .
... |
the pulp and paper industry is modifying its pulping , bleaching , and effluent treatment technologies to reduce the environmental impact of mill effluents .
prebleaching of kraft pulps with xylanases lowers chlorine charges , which reduce chloroorganic discharges [ 13 ] .
tremblay and archibald reported the delign... | the most promising application of xylanases ( e.c .
3.2.1.8 ) is in the prebleaching of kraft pulp .
the present paper reports bleaching effects of a thermoalkali stable xylanase from cellulosimicrobium sp . mtcc 10645 .
the bacterium produced thermo - alkali stable xylanase in a basal medium supplemented with wh... |
the development of hepatic portal venous gas ( hpvg ) is rare but clinically important radiographic finding ( 1 , 2 ) .
it has been reported to have an association with numerous abdominal conditions , including inflammatory bowel diseases , bowel obstruction , and bowel necrosis ( 2 ) .
recently hpvg was also repor... | the development of hepatic portal venous gas ( hpvg ) is rare but it might be associated with serious disease and poor clinical outcome . recently , several iatrogenic causes of hpvg have been reported .
hpvg as a complication of endoscopic balloon dilatation is a previously unreported event .
we experienced a case... |
conjugated linoleic acid ( cla ) is a fatty acid mixture of positional geometric isomers of octadecadienoic acid ( linoleic acid 18 : 2n-6 ) with a conjugated double - bond system ( 1 ) .
different isomers of cla have varied biological functions , such as reducing carcinogenesis , decreasing adipose mass , and modula... | objective(s):this study examined whether conjugated linoleic acid ( cla ) supplementation affects insulin sensitivity and peroxisome proliferator - activated receptor gamma ( ppar- ) and glucose transporter type 4 ( glut-4 ) protein expressions in the skeletal muscles of rats during endurance exercise.materials and met... |
adhesion to dentin may be achieved either following an etch - and - rinse or a self - etch approach .
self - etch approach has been claimed to be user - friendlier and less technique - sensitive
. another important clinical benefit of self - etch adhesives is the absence of , or at least lower incidence of post... | objective .
this study evaluated the effect of ethylenediaminetetraacetic acid ( edta ) conditioning and carbodiimide ( edc ) pretreatment on the shear bond strength of two all - in - one self - etch adhesives to dentin .
methods .
flat coronal dentin surfaces were prepared on one hundred and sixty extracted huma... |
primary amyloid light - chain ( al ) amyloidosis is a rare form of plasma cell dyscrasia characterized by tissue deposits commonly made of monoclonal immunoglobulin light chain .
involvement of the heart , kidney , liver , and autonomic nervous systems is responsible for the poor prognosis of al amyloidosis .
patie... | abstractprimary amyloid light - chain ( al ) amyloidosis is a rare form of plasma cell dyscrasia characterized by tissue deposition of monoclonal immunoglobulin light chain .
kidney involvement is the most frequent manifestation , and patients usually present with glomerular disease.we report an exceptional case of b... |
lymphomatoid granulomatosis ( lyg ) is a rare epstein - barr virus ( ebv)-associated b - cell lymphoproliferative disorder that has similar characteristics as lymphomatous and granulomatous diseases .
the disease is pathologically classified as a large angiocentric and angiodestructive b - cell lymphoma that consists... | a 70-year - old man was admitted to our hospital for evaluation of a rapidly progressive erythrodermia .
he had superficial lymph node swelling and gluteal / inguinal nodosum - like lesions .
a skin biopsy of the erythrodermia showed dense mixed infiltrates distributed throughout the whole dermis , predominantly co... |
. however , symptoms may arise due to occasional obstruction or perforation ( 1 ) .
these objects and long , narrow , or pointed foreign bodies are associated with a high risk of impaction and perforation of the bowel walls ( 2 , 3 ) .
the ingestion of foreign bodies may also lead to penetrating injuries with compl... | foreign body ingestion is not uncommon in clinical practice , and it may occasionally lead to penetration injuries . emergency physicians and radiologists sometimes fail to obtain complete histories including ingestion and may overlook the possibility of foreign body - induced complications .
herein , we report a cas... |
basal cell carcinoma ( bcc ) is a slow growing malignant cutaneous tumor that is locally aggressive but it rarely metastasizes . histopathological examination of the excision biopsy has been the mainstay for diagnosis .
fine needle aspiration cytology ( fnac ) has been recently employed as a simple alternative tool i... | cutaneous basal cell carcinoma ( bcc ) is a slow growing locally aggressive malignant tumor .
it is usually diagnosed on histopathological examination of the excised biopsy . recently ,
fine needle aspiration cytology ( fnac ) is emerging as a simple alternative technique for rapid diagnostic work of nodular and pl... |
in recent years , the world has rapidly entered into an aging society . neglected diseases and illnesses have been continuously detected as our society is aging . like the condition that progresses very slowly in an elderly woman at an old age of over 90 , a number of problems may arise in treatment and decision - maki... | mucinous borderline ovarian tumors ( bots ) occur most often in women between the ages of 20 and 30 .
early - stage detection of the condition has a more favorable prognosis . in this case report , the authors present an elderly 93-year old woman who visited our hospital due to severe abdominal pain after being diagn... |
in general consideration of cervicofacial skeleton , the hyoid bone tends to be overlooked or is given scant attention . however , it is associated with several important functions of the human body such as deglutition , phonation , and respiration .
orthodontic myofunctional therapy has the potential to affect the h... | objective : to evaluate the position of hyoid bone in the subjects treated with twin block appliance.materials and methods : the sample consisted of 40 angle 's class ii division 1 subjects treated with twin block appliance .
lateral radiographs were taken before and after treatment . according to schudy 's facial di... |
cutaneous leishmaniasis ( cl ) is a major public health problem in many countries . however , there are many topical and systematic treatments for cl . at present ,
pentavalent antimonials are still the first drug of choice for the treatment of cl ( 1 ) .
systemic administration of pentavalent antimonials has been ... | pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis ( cl ) . like other treatments
, they can cause adverse reactions including musculoskeletal pain , gastrointestinal disturbances , and mild to moderate headaches . in this paper , we report the first case of an inf... |
metaplastic breast cancer is a rare entity , with an incidence of less than 0.1 - 0.5% of all breast malignancies .
neurofibromatosis type 1 ( nf1 ) is an autosomal dominant multisystem disorder affecting 1 in 3500 people .
it is associated with multiple neoplasms such as optic gliomas and peripheral nerve sheath t... | metaplastic breast cancer is a rare malignancy in the breast .
neurofibromatosis type 1 is an autosomal dominant multisystem disorder associated with multiple neoplasms such as optic gliomas and peripheral nerve sheath tumors .
the association of breast cancer with neurofibromatosis is very rare .
we present a ca... |
the introduction of national mammographic screening programmes and the increasing use of digital mammography and mri have dramatically changed the clinical presentation of dcis . prior to this , dcis made up a small proportion of all breast malignancy and was only diagnosed in patients presenting with a palpable mass ,... | introduction .
this article reviews current management strategies for dcis in the context of recent randomised trials , including the role of sentinel lymph node biopsy ( slnb ) , adjuvant radiotherapy ( rt ) and endocrine treatment
. methods .
literature review facilitated by medline , pubmed , embase and cochra... |
many recent studies have focused on cell therapies , scaffold based and cell based , for cardiovascular diseases primarily because these pathologies still rank among the top ten leading causes of mortality and morbidity worldwide .
annually , thousands of people die due to myocardial infarction , congestive heart fai... | over the years , cardiovascular diseases continue to increase and affect not only human health but also the economic stability worldwide .
the advancement in tissue engineering is contributing a lot in dealing with this immediate need of alleviating human health .
blood vessel diseases are considered as major cardi... |
hereditary sensory neuropathies ( hsn ) are clinically and genetically heterogeneous disorders of autosomal dominant or autosomal recessive inheritance characterized by axonal atrophy and degeneration , predominantly affecting the sensory neurons [ 13 ]
. hallmark features of the dominantly inherited variant subclass... | mutations in the serine palmitoyltransferase subunit 1 ( sptlc1 ) gene are the most common cause of hereditary sensory neuropathy type 1 ( hsn1 ) . here
we report the clinical and molecular consequences of a particular mutation ( p.s331y ) in sptlc1 affecting a patient with severe , diffuse muscle wasting and hypoton... |
understanding and correct analysis of the optical properties of the natural dentition such as color and translucency and the differences between the natural teeth and restorative materials are very important in accurate and consistent shade selection and the proper use of restorative materials in order to achieve clini... | the aim of the present study was to compare the translucency of different shades of two highly aesthetic multilayered restorative composite resins .
in total nine shades from esthet.x and ten shades from filtek supreme composite resins were chosen .
discs of each shade were prepared ( n = 3 ) and light - cured . to... |
human breast cancer represents a group of highly heterogeneous lesions , consisting of about 20 morphologically distinct subtypes 1,2 .
breast cancers also have highly variable molecular and immunohistochemical signatures , and could be roughly divided into 5-categories based on expression of estrogen receptor ( er )... | human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically and immnohistochemically distinct subtypes with substantially different prognoses .
our recent studies have suggested that all breast cancer subtypes , however , may share a common pathway , tumor cell buddin... |
medical errors ( mes ) and adverse drug reactions ( adr ) still persist as important factors for outpatient and in - patient treatments .
additional awareness of patient safety has been established since 1999 , when the institute of medicine issued its report to err is human : building a safer health system .
the... | medication errors ( me ) and adverse drug reactions still continue to be the important factors for out- and in - patient treatments .
mes are critical troubles in all hospitalized populations that can increase length of hospital stay , expenses , mortality and morbidity . in many countries ,
clinical pharmacists ha... |
the global annual incidence of primary malignant central nervous system ( cns ) tumors is around 37 per million for male and 26 per million for female [ 1 , 2 ] , with gliomas constituting the majority . in the past several years
, it has been well established that quite a few clinical and histopathological paramet... | introduction . the ability to reliably differentiate neoplastic from nonneoplastic specimen and ascertain the tumour grade of diffusely infiltrating gliomas ( digs ) is often challenging . aims and objective . to evaluate utility of image morphometry in identifying dig areas and to predict tumour grade .
materials an... |
bariatric surgery is the most effective treatment for severe obesity often resulting in excess weight loss of 5080% [ 1 , 2 ] and improved psychological wellbeing and health - related quality of life ( hrqol ) [ 35 ] .
in addition , particularly , roux en - y gastric bypass ( rygb ) has been shown to lead to remissio... | objective . to investigate the predictive value of type 2 diabetes and lack of physical activity for mental health and health - related quality of life after roux - en - y gastric bypass
. method .
forty severely obese patients undergoing roux - en - y gastric bypass were included in the gasmito study .
informati... |
wegener 's granulomatosis is an uncommon systemic disease characterized by necrotizing vasculitis of small blood vessels with granuloma formation .
central nervous system manifestations of wg include cranial neuritis , mononeuritis multiplex , cerebral vasculitis , and meningeal involvement .
subdural hematoma as a... | wegener 's granulomatosis ( wg ) is a systemic vasculitis , which can involve any organ system in the body ; however , involvement of central nervous system at presentation is very uncommon .
dural involvement in wg has been infrequently reported ; however , presentation with subdural hematoma as the initial manifest... |
the clinical efficacy of many existing antibiotics is being threatened by the emergence of multidrug resistant pathogens .
many infectious diseases have been known to be treated with herbal remedies throughout the history of mankind .
there is a continuous and urgent need to discover new antimicrobial compounds wit... | objective : this study aims to phytochemical and antimicrobial study of euphorbia hirta euphorbiaceae).materials and methods : antimicrobial activity of flavonoids ( free and bound ) of euphorbia hirta l. was determined by disc diffusion assay against four bacteria ( escherichia coli , pseudomonas aeruginosa , proteus ... |
many different types of alloys are available in the dental market , which can be used for prosthetic applications .
the most important factors affecting the choice of these alloys are mechanical properties , workability , biocompatibility and resistance to corrosion.1 some metallic elements are completely safe in the... | purposethe aim of this study was to evaluate the effects of repeated porcelain firing process on the corrosion rates of the dental alloys.materials and methodscr - co , cr - ni and pd - ag alloys were used for this study .
each metal supported porcelain consisted of 30 specimens of 10 for 7 , 9 and 11 firing each .
... |
during april 2008december 2009 in shandong province , 613 blood samples were obtained from hybrid wild boars that had not been vaccinated against prrsv ( table ) . the herd check prrs commercial elisa kit
( idexx laboratories , norcross , ga , usa ) was used for serologic analysis ; 167 ( 27.2% ) of 613 samples were ... | we conducted a serologic investigation of porcine reproductive and respiratory syndrome virus ( prrsv ) in hybrid wild boar herds in china during 20082009 .
prrsv isolates with novel genetic markers were recovered .
experimental infection of pigs indicated that hybrid wild boars are involved in the epidemiology of ... |
there are various types of bags such as shoulder bags and
backpacks , and various styles of carrying a bag .
people use these different types of bags to
carry the things they require in their daily lives .
while carrying a bag and walking , the
body is subjected to physical stress owing to the weight of the b... | [ purpose ] this study was performed to investigate the effect of the length of backpack
shoulder straps on upper trapezius muscle pain threshold and craniovertebral angle .
[ subjects and methods ] there were 25 participants , with ages from 15 to 23 years old .
upper trapezius pain threshold and craniovertebra... |
prior studies reported an association between ambient air concentrations of total suspended particles and so2 during pregnancy and adverse pregnancy outcomes .
we examined the possible impact of particulate matter up to 10 microm ( pm10 ) and up to 2.5 microm ( pm2 .
5 ) in size on intrauterine growth retardation (... | |
radiation retinopathy is a chronic and progressive retinal microangiopathy that can occur even years after radiation treatment for cancer .
radiation retinopathy has been reported secondary to treatment of intraocular tumors , such as uveal melanoma , retinoblastoma , as well as cephalic , nasopharyngeal , orbital , ... | we report a case of a 60-year - old asian male who developed radiation retinopathy 23 years after initial radiotherapy for nasopharyngeal carcinoma and was successfully treated with yellow pattern 577-nm micropulse laser .
secondary macular edema and visual acuity improved following a single treatment session with mi... |
the utilization of multiple pharmacologic agents is an essential component of modern day anesthetic practice .
while there have been numerous advancements in recent years in both analgesic and amnestic medications available for an anesthesiologist to use in clinical practice , the cadre of neuromuscular blocking agen... | pharmacological advances in anesthesia in recent decades have resulted in safer practice and better outcomes .
these advances include improvement in anesthesia drugs with regard to efficacy and safety profiles .
although neuromuscular blockers were first introduced over a half century ago , few new neuromuscular bl... |
gastrointestinal ischemia arises due to a sudden reduction in intestinal blood flow , and it most commonly occurs due to mesenteric thrombosis , vasculitis and torsion of the intestine .
in occlusive conditions , the collateral circuit of the intestine is occluded , which can be seen due to traumas , surgery on aorta... | gastrointestinal ischemia is caused by ischemic colitis in 5060% of cases and is associated with high morbidity and mortality among patients .
ischemic proctosigmoiditis is a very rare disorder with only few cases reported . due to collateral blood supply the rectum
is only affected in 25% of all cases of ischemic ... |
recent research suggests that there is a symbiotic relationship between the non - self ' microbiota and self ' immune system , and both should be considered as one in the superorganism theory .
the microbiota has been shown to have profound effects in the development of gut - associated lymphoid tissue , the differ... | the advent of vaccination and improved hygiene have eliminated many of the deadly infectious pathogens in developed nations .
however , the incidences of inflammatory diseases , such as inflammatory bowel disease , asthma , obesity and diabetes are increasing dramatically .
research in the recent decades revealed t... |
adenomatoidodontogenic tumor ( aot ) is a slow growing lesion , constituting only 2.2% to 7.1% of all odontogenic tumors and 0.1% of jaw tumors , with a predilection for the anterior maxilla of young females in the second decade of life [ 14 ] .
patients are usually referred to dentists with complaints of impacted te... | the present report describe the surgical therapy , clinical course , orthodontic treatment and morphological characteristics of an adenomatoid odontogenic tumor in the maxilla of an 11-year - old patient .
the cystic tumor filled the maxillary sinus and involved a tooth .
marsupialization was accompanied by partial... |
a total of 23 neuropathic diabetic foot patients participated ( 17 men , 6 women ) .
mean age was 59.1 ( sd 12.6 ) years , and mean bmi was 33.0 ( 8.7 ) kg / m .
mean duration of diabetes was 13.8 ( 10.1 ) years , and mean hba1c level was 7.3 ( 1.1 ) percent .
a total of 18 patients had a history of plantar foot ... | objectivetherapeutic footwear for diabetic foot patients aims to reduce the risk of ulceration by relieving mechanical pressure on the foot .
however , footwear efficacy is generally not assessed in clinical practice .
the purpose of this study was to assess the value of in - shoe plantar pressure analysis to evalu... |
mycoplasma hominis usually colonizes the lower urogenital tract and can cause pyelonephritis , pelvic inflammatory disease , chorioamnionitis , rupture of fetal membranes , preterm labor , postpartum fever , postabortal fever , and neonatal infection.19 this organism is a marker for sexual activity , as demonstrated by... | mycoplasma species can not be identified by routine bacteriological culture methods and are resistant to common antimicrobial agents .
mycoplasma hominis usually colonizes the lower urogenital tract and causes pyelonephritis , pelvic inflammatory disease , chorioamnionitis , rupture of fetal membranes , preterm labor... |
the traditional approach to disorders consequent to brain injury centers on the description of concrete symptoms that be shown to correlate significantly with injuries to particular brain regions .
this approach began with the pioneering works of broca and wernicke , and has continued in much contemporary work in n... | summarybackgroundit is well known that traumatic brain injury often changes the way the patient perceives reality , which often means a distortion of the perception of self and the world .
the purpose of this article is to understand the processes of identity change after traumatic brain injury.case reportwe describe... |
although applying the pesticides in rice has increased grain production , their use has raised serious concern . beside the high cost of the pesticides ,
the use of pesticides may contaminate the products , as well as posing a serious danger to human health ( 1 ) .
carbamates , or urethanes , are a group of organic... | a gas chromatography mass spectrometry with spike calibration curve method was used to quantify three carbamate pesticides residue in cooked white rice and to estimate the reduction percentage of the cooking process duration.the selected pesticides are three carbamate pesticides including carbaryl and pirimicarb that t... |
,-unsaturated carboxylic
acids undergo rh(iii)-catalyzed decarboxylative coupling with ,-unsaturated o - pivaloyl oximes to provide substituted pyridines in good
yield .
the carboxylic acid , which is removed by decarboxylation , serves
as a traceless activating group , giving 5-substituted pyridines with
ver... | |
bone is one of the most common sites of metastasis in advanced cancer , present in approximately 5075% of patients .
bone metastases are especially prevalent in patients with prostate , breast , or lung primaries [ 24 ] and are of great concern to both physicians and patients as they can result in complications such ... | objectiveto investigate the quality of life ( qol ) following palliative radiotherapy for painful bone metastases.methodsa literature search was conducted in ovidsp medline ( 1946jan week 4 2014 ) , embase ( 1947week 5 2014 ) , and the cochrane central register of controlled trials ( dec 2013 ) databases .
the search... |
oxaliplatin , a platinum - based chemotherapeutic agent , is effective for the treatment of advanced colorectal cancer.15 unlike other platinum derivatives , oxaliplatin does not cause significant renal impairment or ototoxicity .
the dose - limiting toxicity of oxaliplatin is related to peripheral nerve function and... | backgroundpatients with colorectal cancer treated with oxaliplatin are at risk of hypersensitivity reactions , with the incidence estimated to be 12%20% .
coinfusion of dexamethasone and oxaliplatin could potentially reduce the incidence of these reactions , but oxaliplatin is reported to be incompatible with alkalin... |
in living organisms , communication between individual cells and between cells and the environment plays essential roles in various cellular processes including growth , differentiation , migration , and apoptosis.1 these cellular processes are mediated in large part by signaling pathways triggered by interactions betw... | signaling pathways mediated by receptor tyrosine kinases ( rtks ) and their ligands play important roles in the development and progression of human cancers , which makes rtk - mediated signaling pathways promising therapeutic targets in the treatment of cancer .
compared with small - molecule compounds , antibody - ... |
interpreting the clinical significance of genomic information depends on broad access to dna sequence variants and clinical information about those tested .
some proprietary genetic test providers have developed privately controlled databases containing information essential to interpreting the results of their tests... | sole - source business models for genetic testing can create private databases containing information vital to interpreting the clinical significance of human genetic variations . but incomplete access to those databases threatens to impede the clinical interpretation of genomic medicine . national health systems and i... |
diabetic foot syndrome is one of the most common complications of diabetes . alongside neuropathy and ischemia
this syndrome includes infections within the soft tissues and bony structures of the foot ( as a consequence of neurogenic and vascular abnormalities ) and a less frequent complication
neuropathic osteoart... | the paper presents a case of charcot foot in a patient with long standing type 2 diabetes and complicated by peripheral neuropathy .
it was initially diagnosed by an ultrasound examination and subsequently confirmed by an x - ray and an magnetic resonance imaging .
diabetic neuropathy is nowadays the most frequent ... |
abdominal aortic aneurysm ( aaa ) is a life - threatening disease when rupture occurs .
elective open surgical repair ( osr ) has been the optimal therapy to prevent aaa rupture . however , after the first introduction by parodi et al .
( 1 ) , endovascular aneurysm repair ( evar ) has increased dramatically and is... | this study was designed to compare the hospital - related costs of elective abdominal aortic aneurysm ( aaa ) treatment and cost structure between endovascular aneurysm repair ( evar ) and open surgical repair ( osr ) in korean health care system .
one hundred five primary elective aaa repairs ( 79 osrs and 26 evars ... |
mite demodex is an ectoparasite infesting the areas of face rich in pilo - sebaceous units and less commonly other seborrheic sites like upper and medial region of chest and back are also involved .
majority of the patients are immune - compromised though immunocompetent are not spared , nevertheless atypical present... | demodicosis is a common parasitic infection of the hair follicles and the pilosebaceous unit by the demodex mites viz .
demodex folliculorum and demodex brevis .
infection by this parasite is common among immunocompromised and elderly .
we report a case of facial demodicosis which presented like atypical rosacea ... |
pyrethrums are organic , environment - friendly insecticides having a knock down effect on a variety of insects .
pyrethrin and pyrethroids have quick action against insects , low toxicity , repellent properties , and virtually no insect immunity .
the very low potential for toxicity in human being is due to its ... | this report describes a 35 year old male who presented with seizures after consuming 4 - 5 bottles of all - out a commercial composition of pyrethroid used as insecticides .
our case report supports authors reporting an association of pyrethroid poisoning with status epilepticus . |
przyjcie na oddzia intensywnej opieki ( oit ) bywa poprzedzone wydarzeniami , ktre mog prowadzi do trwaych ubytkw neurologicznych .
ocena stenia biaka s100 w osoczu moe by klinicznie uyteczna w przewidywaniu , jaki bdzie stan neurologiczny pacjenta po nagym zatrzymaniu krenia ( nzk ) .
nie wiadomo , czy wyniki te m... | introductionadmission to the intensive care unit ( icu ) may be preceded by dramatic events leading to permanent neurological injury .
plasma s100 protein levels are proved to be clinically useful in predicting neurological outcome following cardiac arrest .
it is unclear , however , whether this may be extrapolate... |
given the ongoing incidence of human immunodeficiency virus ( hiv ) infection , thanks to the effectiveness of antiretroviral therapy ( art ) , especially its well - known subclass of protease inhibitors ( pis ) that are coming up every day , hiv - infected patients are going to live longer than ever before .
in addi... | background : there is strong evidence regarding the patterns of alteration in the blood parameters in human immunodeficiency virus ( hiv)-positive patients .
however , no consensus has been reached in this regard and the results vary from different regions and studies .
our study aims to report these patterns in a ... |
clostridium perfringens ( c. perfringens ) is a ubiquitous bacterium broadly distributed in environment .
it also presents as a normal intestinal flora of humans and domestic animals . c. perfringens is an arsenal producing a wide range of bacterial toxins , of which
genes encoding 17 distinct toxins have been iden... | introduction . clostridium perfringens ( c. perfringens )
beta2 toxin ( cpb2 ) is an important virulent factor of necrotic enteritis in both animals and humans .
however , studies of its pathogenic roles and functional mechanisms have been hampered due to the difficulty of purification and lack of specific antibodi... |
we report the unique case of a patient with brachiocephalic deep venous thrombosis ( dvt ) and persistent foramen ovale ( pfo ) who developed ischemic stroke in the absence of other risk factors for stroke .
this may suggest the need for more detailed search for the embolic source in selected cases .
a large percen... | up to 40% of ischemic strokes have no known cause ( cryptogenic ) .
the prevalence of persistent foramen ovale ( pfo ) amongst patients with cryptogenic stroke ( cs ) is twice as high as that of the normal population , therefore suggesting a causal relationship between the two entities .
however , pfo by itself is ... |
recently , several cases of splenic cyst with high serum levels of carbohydrate antigen 19 - 9 ( ca 19 - 9 ) , cancer antigen 125 ( ca 125 ) and carcinoembryonic antigen ( cea ) have been reported .
it has been suggested that the cysts are produced by the inner epithelium of the cyst .
splenic cysts are mostly asym... | splenic cyst is a relatively rare disease ; however , the occurrence of complications associated with its rupture is even more rare .
a 20-year - old female patient who had severe abdominal and left shoulder pain was admitted to our hospital .
the patient 's abdomen was hard and tender to the touch and she presente... |
since guinto , et al . reported a case of spontaneous regression of a herniated lumbar disc in 1984 , this phenomenon in lumbar discs has been well documented and discussed [ 2 - 4 ] .
however , there have been fewer reports of spontaneous regression of cervical disc herniation ( cdh ) [ 5 - 7 ] , especially ones con... | the spontaneous regression of herniated cervical discs is not a well - established phenomenon .
however , we encountered a case of a spontaneous regression of a severe radiculopathic herniated cervical disc that was treated with acupuncture , pharmacopuncture , and herb medicine .
the symptoms were improved within ... |
because coronary heart diseases often manifest as abnormalities of the ventricular geometry and wall kinematics , noninvasive cine medical imaging techniques are of significant clinical value , such as magnetic resonance imaging ( mri ) , to provide shape and motion information of the myocardium ( ) . in the past thre... | although accurate and robust estimations of the deforming cardiac geometry and kinematics from cine tomographic medical image sequences remain a technical challenge , they have significant clinical value .
traditionally , boundary or volumetric segmentation and motion estimation problems are considered as two sequent... |
accidents can take place in a wide variety of environments and settings ; however , the home , which people regard as the safest place , is the most likely location .
home accidents comprise 35% of all unintentional injuries in childhood , and the majority of victims are toddlers and pre - school children .
televis... | backgroundfemoral artery pseudoaneurysm following cardiac catheterization is a serious groin complication requiring careful assessment and prompt intervention.aimsthe risk of femoral artery pseudoaneurysm is estimated at 0.6 to 17% following diagnostic and interventional procedures.methodsthe clinical use of bedside ul... |
antireflection ( ar ) technology plays an important role in the fabrication of high - efficiency solar cells by increasing light coupling into the active region of devices .
generally , a relatively low - light reflectivity can be obtained for crystalline silicon solar cells by combining surface texturization with si... | an efficient antireflection coating is critical for the improvement of silicon solar cell performance via increased light coupling . here
, we have grown well - aligned zno nanowhisker ( nw ) arrays on czochralski silicon solar cells by a seeding - growth two - step process . it is found that the zno nws have a great... |
scientific collaboration often necessitates sharing data with researchers outside the organization that collects and maintains the data .
sharing microdata records of individual information on a relatively small number of subjects carries a risk of disclosure ( determining the identity of one or more individuals ) ... | objective . ensuring privacy of research subjects when epidemiologic data are shared with outside collaborators involves masking ( modifying ) the data , but overmasking can compromise utility ( analysis potential ) .
methods of statistical disclosure control for protecting privacy may be impractical for individual r... |
we report a case of a healthy 22-year - old man who underwent an arthroscopic right acl reconstruction with hamstring grafts in january 2010 , 6 months after his initial injury .
the graft was fixed with an endobutton ( smith & nephew , andover , ma , usa ) for the femoral side , and a biosure bioabsorbable screw ( s... | infections following anterior cruciate ligament reconstruction are rare , with no previous reports citing mycobacterium abscessus as the culprit pathogen . a 22-year - old man presented twice over three years with a painful discharging sinus over his right tibia tunnel site necessitating repeated arthroscopy and washou... |
they have poor communication with the normal lymph systems and therefore collect lymph.[15 ] the most common location in the mouth is the dorsum of tongue , followed by lips , buccal mucosa , soft palate , and floor of the mouth .
these tumors typically present in children younger than 2 years and in a significant nu... | lymphangiomas are developmental malformations and have a marked predilection for the head and neck region .
they are benign proliferation of lymphatic vessels and represents hamartomas of malformed lymphatics .
the most common location in the mouth is the dorsum of tongue , followed by lips , buccal mucosa , soft p... |
the rate of endometriosis is estimated to be approximately 1015% in women of reproductive age and 2550% in infertile women .
several mechanisms for the association of endometriosis with infertility have been proposed , including altered pelvic anatomy , impaired ovarian function , distorted microenvironment , altered... | backgroundthe aim of this study was to investigate the effect of natural cycle ( nc ) endometrial preparation for frozen - thawed embryo transfer ( fet ) in women with advanced endometriosis.material/methodsthis retrospective study included 179 patients with stage iii
iv endometriosis who underwent 233 fet cycles at ... |
in the early 1970s , this picture of thymic selection was still being colored in .
immunologists were unaware that the antigens recognized by t cells were peptides bound to mhc molecules . and tcrs themselves
peter doherty laid out the nobel prize winning rules of what is now known as self - mhc restriction in 197... | in the 1970s , michael bevan showed that t cells only recognize antigens in cells that have the same type of major histocompatibility complex ( mhc ) molecule present in the thymus where the t cells mature .
his work provided the first clues to how thymic self - mhc molecules select the cells that make up the mature ... |
coomb 's positive hemolytic anemia is a very rare cause of anemia associated with tb and only few case reports have been published . the case presented here had tuberculosis lymphadenitis associated coomb 's positive hemolytic anemia which resolved on treatment with anti tuberculous treatment .
a 19-year - old girl p... | anemia in tuberculosis is usually anemia of chronic disease .
severe hemolytic anemia is exceedingly rare in tuberculosis patients .
we report a patient diagnosed with tubercular lymphadenitis complicated by coomb 's positive hemolytic anemia .
patient responded well to antituberculous treatment .
hematological... |
the incidence rate ranges from 4.5 to 20% after pneumonectomy and is 0.5% after lobectomy .
the risk of developing a bronchopleural fistula is greater when surgery is performed for a malignancy and even more when radiation or chemotherapy is given [ 1 , 2 , 3 ] . until now
there are no established guidelines , nor ... | bronchopleural fistulas can occur as a rare but severe complication after pulmonary resection .
established guidelines for the proper treatment of patients with bronchopleural fistulas do not exist .
apart from attempts to close the fistula , emphasis is placed on preventive measures , early treatment with antibiot... |
there has been a recent surge in interest in the eastern philosophies for mental health care .
for instance , successful amalgamation of zen 's principles with cognitive behavioral therapy ( cbt ) in the form of dialectical behavioral therapy ( dbt ) , as well as the psychotherapeutic application of mindfulness is on... | the bhagavad gita is based on a discourse between lord krishna and arjuna at the inception of the kurukshetra war and elucidates many psychotherapeutic principles . in this article
, we discuss some of the parallels between the gita and contemporary psychotherapies .
we initially discuss similarities between psycho... |
central diabetes insipidus ( cdi ) results from deficiency synthesis , release of arginine vasopressin ( avp ) , or both .
polyuria and polydipsia are important clues to the diagnosis ; nonetheless , approximately 40% of the patients have symptoms other than polyuria and polydipsia at presentation .
infants may hav... | objective . in pediatric central diabetes insipidus ( cdi ) , etiology diagnosis and pituitary function monitoring are usually delayed .
this study aimed to illustrate the importance of regular follow - up and pituitary function monitoring in pediatric cdi .
methods .
the clinical , hormonal , and neuroradiologic... |
retroperitoneal fibrosis ( rpf ) is a rare disease with an unclear etiology and is characterized by chronic nonspecific inflammation of the retroperitoneum .
the hallmark of this disease and its main complication is ureteral entrapment , which is often silent and progressive , .
several studies have noted that pati... | retroperitoneal fibrosis ( rpf ) is a rare disease characterized by the presence of fibroinflammatory tissue around the abdominal aorta and ureteral entrapment in most cases .
idiopathic rpf is frequently reported in association with autoimmune diseases ; however , there have been few reports of idiopathic rpf associ... |
the dutch healthcare inspectorate is in search for a better insight into how to measure the quality of integrated care .
the central purpose of this study was to identify indicators that provide insight into the performance of the chain as a whole , by means of a clinical logic model .
the extent to which such requ... | introductionthe dutch healthcare inspectorate is in search for a better insight into how to measure the quality of integrated care .
the central purpose of this study was to identify indicators that provide insight into the performance of the chain as a whole , by means of a clinical logic model.theory and methodscha... |
in patients with type 2 diabetes , glycaemic control typically deteriorates over time due to the progressive nature of the disease , and a significant proportion of patients with type 2 diabetes will require exogenous insulin therapy to reach glycaemic goals 1,2 .
once - daily basal insulin is the most convenient str... | aimsto compare the efficacy and safety of two insulin intensification strategies in patients with type 2 diabetes inadequately controlled on basal insulin glargine with metformin and/or pioglitazone.methodsa multinational , randomized , open - label trial that compared insulin lispro low mixture ( lm25 ; n = 236 ) twic... |
a critical need within the biochemical and biomedical research sector is the identification of low - abundance biomarkers that are predictive of early - stage disease or that correlate with therapeutic outcome or toxicity.(1 ) while the interest in the potential and value of biomarkers has never been greater , the rese... | many low - abundance biomarkers for early detection of cancer and other diseases are invisible to mass spectrometry because they exist in body fluids in very low concentrations , are masked by high - abundance proteins such as albumin and immunoglobulins , and are very labile .
to overcome these barriers , we created... |
most of the procedures are performed under sedation and/or analgesia due to the discomfort or pain , and adequate sedation may improve the quality of colonoscopy .
sedation for endoscopy can be classified into minimal , moderate , and deep sedation , depending on the different types of procedures , and moderate sed... | backgroundpropofol is widely used in sedation for colonoscopy , but its adverse effects on cardiovascular and respiratory systems are still concerning .
the present study investigated whether target controlled infusion ( tci ) of propofol could provide a better sedation quality than manually controlled infusion ( mci... |
over the past 20 years , erythropoiesis stimulating agents ( esas ) have been a mainstay in anemia treatment in chronic kidney disease ( ckd ) and end - stage renal disease ( esrd ) patients .
although anemia treatment improves survival in this population , correction of hemoglobin ( hb ) to a normal range using esas... | it has been previously reported that a higher erythropoiesis stimulating agent ( esa ) dose in hemodialysis patients is associated with adverse outcomes including mortality ; however the causal relationship between esa and mortality is still hotly debated .
we hypothesize esa dose indeed exhibits a direct linear rela... |
non - melanomatous skin cancer ( nmsc ) is the single most common cancer in the us with an incidence of 2 - 3 million cases per year .
nmsc is comprised of basal cell carcinoma ( bcc ) and squamous cell carcinoma ( scc ) , and also includes merkel cell carcinoma ( mcc ) and adnexal tumors .
while surgical excision ... | purposenon - melanomatous skin cancer ( nmsc ) is the single most common cancer in the us .
radiation therapy is an excellent treatment alternative to surgery
. high - dose - rate ( hdr ) brachytherapy and external beam radiotherapy ( ebrt ) are commonly used radiation treatment modalities but little data is publis... |
human respiratory syncytial virus ( rsv ) is one of the most important infectious agents causing acute lower respiratory tract illness , such as bronchiolitis and pneumonia , in infants and young children [ 1 , 2 ] .
viral rna generated during rsv replication is recognized by host pattern recognition molecules , such... | human respiratory syncytial virus ( rsv ) sometimes causes acute and severe lower respiratory tract illness in infants and young children .
rsv strongly upregulates proinflammatory cytokines and the platelet - activating factor ( paf ) receptor , which is a receptor for streptococcus pneumoniae , in the pulmonary epi... |
clinical pharmacologists play an important role in the development of these skills by teaching clinical pharmacology and therapeutics ( cp&t ) to undergraduate medical students .
although the approaches to teaching cp&t have undergone many changes over the last decennia , it is essential that the actual teaching of c... | backgroundthe rational prescribing of drugs is an essential skill of medical doctors .
clinical pharmacologists play an important role in the development of these skills by teaching clinical pharmacology and therapeutics ( cp&t ) to undergraduate medical students .
although the approaches to teaching cp&t have unde... |
allogeneic hematopoietic stem cell transplantation ( hsct ) is the treatment of choice for many hematological malignancies and primary immunodeficiencies .
gvhd , the life - threatening and frequent complication of allogeneic hsct ( 1 ) , is due to mature donor t cells present in the transplant .
however , removal ... | cd4+cd25 + immunoregulatory t cells play a pivotal role in preventing organ - specific autoimmune diseases and in tolerance induction to allogeneic organ transplants .
we investigated whether these cells could also control graft - versus - host disease ( gvhd ) , the main complication after allogeneic hematopoietic s... |
each year 300 million to 3 billion people are infected and more than 600,000 die , making malaria the most important vector - borne disease in the world .
of the five parasites that infect humans ( p. falciparum , p. vivax , p. malariae , p. ovale , and p. knowlesi ) , p. falciparum causes the most severe disease and... | to examine human gene expression during uncomplicated p. falciparum malaria , we obtained three samples ( acute illness , treatment , and recovery ) from 10 subjects and utilized each subject 's recovery sample as their baseline . at the time of acute illness ( day 1 ) , subjects had upregulation of innate immune respo... |
pmds were obtained from lister et al . , generated from bisulfite sequencing in fibroblast cells .
dnam data and hypomethylation block regions were obtained from hansen et al .. affymetrix hgu133plus2 expression data was obtained from the gene expression barcode project .
idat files for 17 normal colon and 34 colon... | visualization is an integral aspect of genomics data analysis where the output of procedures performed in computing environments like bioconductor is often visualized .
algorithmic - statistical analysis and interactive visualization are usually disjoint but are most effective when used iteratively .
we introduce t... |
during the last decades , there have been great advancements in the field of preventive medicine .
research has demonstrated that nutrition plays a crucial role in the prevention of chronic diseases .
it proposes to consider food not only vital to survive , but also a mean for mental and physical well - being , con... | background : during the last decades , there have been great advancements in the field of preventive medicine .
research has demonstrated that nutrition plays a crucial role in the prevention of chronic diseases .
the concept of functional food was first introduced in japan during the 1980s .
it proposes to consi... |
service quality is an important element in growth , success and survival of any given organization , assuming the importance of a principle for predicting future developments of the organization ( 1). considering the ongoing globalization process , health care rendering systems development as well as the increase in pe... | background : radiology department as a service provider organization requires realization of quality concept concerning service provisioning knowledge , satisfaction and all issues relating to the customer as well as quality assurance and improvement issues .
at present , radiology departments in hospitals are regard... |
obesity is linked to many deleterious health consequences , including insulin resistance , type 2 diabetes ( t2d ) and the metabolic syndrome , a group of metabolic risk factors predisposing to t2d , and cardiovascular disease .
low - grade , chronic inflammation is considered as one of the most important mechanisms ... | chronic inflammation is considered a causal risk factor predisposing to insulin resistance .
however , evidence is accumulating that inflammation confined to the liver may not be causal to metabolic dysfunction . to investigate this
, we assessed if hepatic inflammation explains the predisposition towards insulin r... |
clubroot caused by the obligate soil - borne parasite plasmodiophora brassicae is considered the most important soil - borne disease of brassica crops , such as broccoli , cabbage , canola and others ( dixon 2014 ; donald and porter 2009 ; donald and porter 2014 ) .
primary phases that occur in the root hair and seco... | a sand solution technique demonstrated the capacity for a commercial seaweed extract from durvillaea potatorum and ascophyllum nodosum ( seasol commercial ) to significantly suppress infection of broccoli by plasmodiophora brassicae . in the primary stages of infection ,
the extract reduced the number of plasmodia fo... |
all procedures followed the nih guidelines for the care and use of laboratory animals , and were approved by the columbia university or national institute of dental and craniofacial research animal care and use committees .
t2r32-sapphire mice are transgenics engineered to express the blue shifted gfp - derivative , ... | in the tongue , distinct classes of taste receptor cells detect the five basic tastes , sweet , sour , bitter , sodium salt , and umami1,2 . among these qualities , bitter and sour stimuli
are innately aversive , whereas sweet and umami are appetitive , and generally attractive to animals .
in contrast , salty tast... |
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