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the epstein - barr virus ( ebv ) is a gammaherpesvirus that primarily infects b cells and in some cases epithelial cells .
ebv infection leads to a lifelong latent phase in which the viral dna episome remains attached to the host s genome in the nucleus of the ebv - infected cells . like other latent viruses
, ebv ... | abstractthe epstein - barr virus ( ebv)-encoded noncoding rnas eber1 and eber2 are highly abundant through all four latency stages of ebv infection ( iii - ii - i-0 ) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro . in vivo ,
ebv - infected b cells derived from fre... |
a chronic , progressive , and complex metabolic disturbance , the metabolic syndrome ( mets ) , is closely related to serious cardiovascular and emotional complications [ 1 , 2 ] .
its increasing prevalence worldwide has pushed the mets more and more under the spotlight during the last decades .
incontrovertibly ... | the present trial aimed to evaluate the effects of pioglitazone on the mental status of nondiabetic metabolic syndrome patients . from 145 patients screened , 104 eligible volunteers ( 57% female ; age 2070 years ) were enrolled and randomly assigned to receive either pioglitazone ( uptitrated to 30 mg / day ; p = 53 ... |
study population - this study ( approved by the ethical committee of ain
shams university ) included 99 cases collected from cairo , egypt ( el demerdash and el
bakri hospitals ) , al qalubia ( banha hospital ) , al menia ( el menia hospital ) and al
monofia ( sheben el kom hospital ) from august 2011-february 20... | epstein - barr virus ( ebv ) plays a major role in liver pathology . similar to other
members of the herpesvirus family , ebv establishes a persistent infection in more
than 90% of adults .
the aim of this study was to evaluate the impact of ebv and
chronic hepatitis c co - infection ( hcv ) on biochemical and ... |
semipalatinsk is a well - known region of kazakhstan because of the presence of the semipalatinsk nuclear test site ( snts ) and its close proximity to china , where the lop nor test base is situated . in the period from 1949 to 1962 125 nuclear tests ( including 25 near - surface nuclear tests )
the date of 29 augus... | a tooth enamel electron spin resonance ( esr ) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the semipalatinsk region of kazakhstan , which was exposed to radioactive fallout traces from nuclear explosions in the semipalatinsk nuc... |
the concept of minimal invasive dentistry has evolved as a consequence of an increased understanding of caries and the development of adhesive restorative materials . within this concept , prevention and hard tissue preservation
are the primary goals , and dentists are encouraged to prefer a more conservative and bio... | the aim of this study was to evaluate the survival of single- and two - surface atraumatic restorative treatment ( art ) restorations in the primary and permanent dentitions of children from a high - caries population , in a field setting .
the study was conducted in the rainforest of suriname , south america .
art... |
sepsis and septic shock in newborn infants have a high risk of
morbidity and mortality . despite advances in medicine ,
early clinical signs are
nonspecific and the laboratory criteria are also not fully reliable .
warning signs and symptoms are often subtle and can easily be
confused with noninfective causes... | background .
sepsis is an important cause of mortality in newborns .
however , a single reliable marker is not available for the diagnosis of neonatal late - onset sepsis ( nls ) .
the aim of this study is to evaluate the value of serum amyloid a ( saa ) and procalcitonin ( pct ) in the diagnosis and follow - up ... |
uterine leiomyosarcoma ( lms ) represents 25 - 36% of uterine sarcomas and 1% of uterine malignancies .
although the disease is mostly confined to the uterus , the local and distant metastasis rates are high and long - term survival rates are between 20% and 60% .
the possible sites of metastasis are the peritoneal... | uterine sarcomas are rare and represent approximately 3.2% of all invasive uterine cancers .
the annual incidence rate is less than two per 100,000 women . the median age at which uterine sarcoma diagnosed is 56 years .
the most common histologic pattern is leiomyosarcoma ( lms ) which originates from the myometriu... |
oesophagus carcinoma is a common malignancy in china and its incidence in 2009 was 22.1 per 100,000 population.1 higher incidence has been reported in southern china including shantou .
about 15% of oesophageal cancers arise in the upper thoracic region of the oesophagus . because of its more posteriorly located anat... | introductionflattening filter - free ( fff ) radiation beams have recently become clinically available on modern linear accelerators in radiation therapy .
this study aimed to evaluate the dosimetric impact of using fff beams in intensity - modulated radiotherapy ( imrt ) for early - stage upper thoracic oesophageal ... |
endovascular treatment of large vessel acute ischemic strokes in appropriately selected patients has been endorsed as evidence - based care.1
2 the next steps in advancing this therapy are to develop systems of care that can be divided into prehospital and intra - hospital pathways .
other time - dependent treatmen... | backgrounddelays in delivering endovascular stroke therapy adversely affect outcomes .
time - sensitive treatments such as stroke interventions benefit from methodically developed protocols . clearly defined roles in these protocols allow for parallel processing of tasks , resulting in consistent delivery of care.obj... |
in the current issue senn and colleagues present their findings from a study aimed at validating a new version of the flotrac / vigileo monitor ( edward lifesciences , irvine , ca , usa ) , a system that measures cardiac output using the arterial pulse contour method .
the method was first used commercially in the ... | the present study was performed to test a new software version of the flotrac / vigileo using head - up head - down tilting in post - cardiac surgery patients .
impressive improvements in bland and altman limits of agreement from 37.5% to 21.6% were recorded .
the results , however could be attributed to a failure... |
the initial inflammatory response is inherently designed to eradicate microorganisms , promote healing following injury , and restore homeostasis .
however , perpetual or excessive inflammatory response may overwhelm the compensatory capacities of the host , eventuating in multiple - organ failure and patient demise ... | background .
morbid obesity is believed to be an extreme of the metabolic spectrum .
moreover , diabetes is hypothesized to be associated with a chronic inflammatory state that is not observed in nondiabetic healthy individuals .
we investigated the differences in expression of inflammatory cytokines induced by s... |
the terminology for squamous vulvar intraepithelial neoplasia ( vin ) was established by the international society for the study of vulvar disease ( issvd ) . in this classification ,
abnormal changes in vulvar tissue diagnosed by cytology are categorized as vin1 , vin2 , or vin3 , but vin1 has a low malignant potent... | summarybackgroundvin usual type appears to be related to the hpv s oncogenic types .
the aim of this prospective multicenter study was to evaluate the re - infection rate of high - risk hpv and the recurrence rate of vin usual type after surgical treatment.material/methodsthe study enrolled 103 women affected by vin ... |
bladder exstrophy is a rare malformation , with the incidence of 1 in every 30,00040,000 births .
it occurs when the abdominal wall and underlying structures , including the ventral wall of the bladder , fail to fuse in utero . as a result
, the lower urinary tract is exposed , and the everted bladder appears throu... | background : the aim of this study was to investigate the efficacy of the rectus abdominis myo - peritoneal flap ( ramp ) technique for the closure and augmentation of small , non - elastic , non - compliant bladder exstrophies.materials and methods : the ramp technique was used in three boys with bladder exstrophy who... |
prevalence of diabetes is rising rapidly in developing countries , and the global number of diabetes is estimated to reach 366 million in 2030 among adults aged 20 years [ 1 , 2 ] .
both type 1 and type 2 diabetes are powerful and independent risk factors for coronary artery disease ( cad ) , stroke , and peripheral ... | objectives . to assess thyroid function and associated risk factors in nepalese diabetes mellitus patients . methods .
a cross - sectional study was carried out among 419 diabetes mellitus patients at b. p. koirala institute of health sciences , dharan , nepal .
information on demographic and anthropometric variabl... |
legionellosis is most often attributed to inhalation of contaminated aerosols from manmade water systems or , in the case of legionella longbeachae , to inhalation of contaminated potting mixes or composts [ 13 ] . from 2003 to 2004 , active population - based surveillance for atypical bacterial respiratory pathogens w... | members of the gram - negative genus legionella are typically found in freshwater environments , with the exception of l. longbeachae , which is present in composts and potting mixes . when contaminated aerosols are inhaled , legionellosis may result , typically as either the more serious pneumonia legionnaires ' disea... |
this species of wild boars live in condensed populations in south and southwest , north and northeast forests of iran .
wild boar as omnivores consume everything including vegetables , mushrooms , seeds , larvae , reptiles , mammals , birds and their eggs and even carrion and corps of animals .
hence , they are con... | background : wild boars , sus scrofa , of wide distribution considered as a potential source of zoonotic parasites .
the current study aimed to assess the prevalence of helminth infections in wild boars in the persian gulf coastal area ( bushehr province ) , southwestern iran.methods:twenty-five wild boars , includin... |
it is widely accepted that patients with unilateral amblyopia can have a relative afferent pupillary defect ( rapd ) .
there have been many reports demonstrating a reduction in the pupil response for amblyopic eyes ( brenner 1969 ; greenwald and folk 1983 ; portnoy et al 1983 ; firth 1990 ; barbur et al 1994 ; donahu... | relative afferent pupillary defects ( rapds ) in amblyopia have been reported , and it is widely accepted that amblyopes can have an rapd .
we investigated whether or not this could be confirmed by the use of binocular pupillography .
we examined twelve patients ( 6 males and 6 females , aged 757 years ) with unila... |
more than 40 years ago , the structural composition of antibodies and functional consequences thereof became elucidated by crystallizing and analyzing haptenbinding fab fragments .
the first xray structure of an antibody was revealed in 1973 when poljak et al .
published the structure at 2.8 resolution of the f... | summaryhaptenbinding antibodies have for more than 50 years played a pivotal role in immunology , paving the way to antibody generation ( as haptens are very important and robust immunogens ) , to antibody characterization ( as the first structures generated more than 40 years ago were those of hapten binders ) , and... |
accurate elucidation of lesions in patients with traumatic brain injury ( tbi ) is essential for guiding treatment strategies , for providing information regarding final outcomes .
diffuse axonal injury ( dai ) is the predominant mechanism of tbi , and its sequelae are the most frequent cause of poor clinical outcome... | diffuse axonal injury is the predominant mechanism of injuries in patients with traumatic brain injury .
neither conventional brain computed tomography nor magnetic resonance imaging has shown sufficient sensitivity in the diagnosis of diffuse axonal injury . in the current study , we attempted to demonstrate the use... |
odontogenesis is controlled by interactions between the epithelial and mesenchymal components of developing dental tissues .
it is thought to be initiated by an increase in the level of angiogenic stimuli and a concomitant decrease in the level of angiogenic inhibitors .
these factors are produced by tumor cells , ... | background : cyst and tumors arise from tissue remains of odontogenesis , these interactions have been considered to play an important role in the tumorigenesis of odontogenic lesions .
the connective tissue stroma has an essential role in the preservation of epithelial tissues and minor alterations in the epithelium... |
negative myoclonus ( nm ) is a condition characterized by brief postural lapses of muscle tone , which can be demonstrated via electromyography ( emg ) recordings.1,2 nm frequently occurs in association with metabolic encephalopathies .
the emg correlate of nm is a brief ( < 500 ms ) silent period that is not precede... | here we report a patient who suffered an acute infarction of the contralateral postcentral cerebral cortex and subsequently developed unilateral partial epilepsy with negative myoclonus .
the findings of brain magnetic resonance imaging , polygraphic recordings of the postcentral somatosensory area , and response to ... |
namcs is a probability sample survey of office - based physicians in the united states conducted by cdc s national center for health statistics .
bureau of the census has been responsible for field operations and data collection since namcs became an annual survey in 1989 .
a report describing sample design , sampl... | during the 1990s , as antimicrobial resistance increased among pneumococci , many organizations promoted appropriate antimicrobial use to combat resistance .
we analyzed data from the national ambulatory medical care survey , an annual sample survey of visits to office - based physicians , and the national hospital a... |
modern dental education integrates conventional methods and new training policies such as simulation and virtual reality systems [ 13 ] .
the current approach to training of hand skills for dental students involves the use of voxel - based models in order to represent a virtual tooth model . however , it is not easy ... | objective : educational teaching of the diagnosis of resorbed root for pulpectomy in deciduous teeth radiography has always been a big challenge in pediatric dentistry.the purpose of the study was to propose a new practical methodology to improve the quality of learning in students of dentistry.materials and methods : ... |
plants are indeed essential to mankind and most plants are harmless , but some cause irritant , allergic and phototoxic dermatitis when in contact with human skin .
most dermatitis inducing plants belong to a limited number of families like alliacae , anacardiaceae , cactaceae , compositae , cruciferae , hennadiaceae... | background : plants are ubiquitous in nature and are essential for human life , though some do have detrimental effects . in india , there are various indigenous and foreign plants that are well known to cause dermatitis , parthenium hysterophorus being the foremost.aims of the study : to study the clinical features of... |
metabolic syndrome describes a combination of metabolic abnormalities that include central obesity , dyslipidemia , hypertension , insulin resistance , and a pro - inflammatory and pro - thrombotic state .
an important group of pharmacological targets for the treatment of metabolic syndrome are the peroxisome prolife... | abstract.glycogen synthase 2 ( gys-2 ) is the ratelimiting enzyme in the storage of glycogen in liver and adipose tissue , yet little is known about regulation of gys-2 transcription .
the peroxisome proliferator - activated receptors ( ppars ) are transcription factors involved in the regulation of lipid and glucose... |
a 36-year - old woman was referred to our clinic with a diagnosis of foveal cyst ou , which were detected upon fundus examination in june 2005 .
after mastectomy , she had been started on toremifen , at a daily dose of 40 mg .
optical coherence tomography ( oct ) showed a focal defect of the outer retinal layer ou ... | to describe the clinical and optical coherence tomography ( oct ) features of a macular hole ( mh ) or its precursor lesion in patients treated with systemic antiestrogen agents .
we reviewed the medical history of the patient , ophthalmic examination , and both fundus and oct findings .
three female patients recei... |
chronic pain is defined as pain lasting over a period of at least 3 months.1 patients with chronic pain are frequently seen in departments of hand surgery.2 whereas a large proportion of patients benefit from surgical interventions , some continue to suffer from pain regardless of such therapeutic measures.3 depending ... | the aim of this prospective study was to examine to what extent anxiety and depressive symptoms predict the level of pain at 4-month follow - up in hand surgery patients .
a total of 132 consecutive patients ( mean age : 51.517.1 years , 51.9% female ) of a tertiary center for hand surgery participated in this study ... |
the papers in this issue cover aging , as well as depression , dementia , and stroke , and include a range of interventions , including manipulations in behavior ( physical and cognitive activity / exercise ) , physiological factors ( caloric restriction , cholesterol ) , pharmacologic treatments ( ampa receptors ) , m... | neuroplasticity can be defined as a final common pathway of neurobiological processes , including structural , functional or molecular mechanisms , that result in stability or compensation for age- or disease - related changes .
the papers in this issue address the aging process , as well as depression , dementia , a... |
population studies in sweden and many other countries show that hypertension is a common condition , which seriously affects future health and quality of life .
it is also evident that other diseases and cardiovascular risk factors interact with high blood pressure in determining the individual global risk .
those ... | this study investigated the association between score and the 2007 esh - esc blood pressure categories and explored achievements of blood pressure goals considering global risk . in 20012005 , a random sample of inhabitants aged 3074 years in southwestern sweden was invited to a survey of cardiovascular risk factors . ... |
dengue infection , an arthropod - borne viral hemorrhagic fever , continues to be a major challenge to public health in south - east asia .
estimates suggest that annually over 50 million cases of severe dengue occur in asian countries with a case fatality rate of lesser than 5% . of these
although dengue virus is ... | background : the spectrum of liver dysfunction in children with dengue infection is wide and has been associated with disease severity.aims:this study was undertaken to estimate the range of hepatic involvement in dengue infection in children.materials and methods : this study assessed the biochemical and clinical prof... |
bone metastases originating from esophageal cancer are uncommon and occur in about 9% of newly diagnosed patients , and prognosis is poor .
generally , treatment for cancer patients with distant metastasis differs from that for patients without distant metastasis .
the standard treatment for patients with distant m... | a 63-year - old man visited the clinic with numbness in the right hand .
magnetic resonance imaging demonstrated multiple low - intensity lesions in the cervical vertebrae and sacrum , which was suspicious of cervical bone metastasis .
fluorodeoxyglucose positron emission tomography / computed tomography revealed a... |
animals and treatment : the experimental design was approved by the
laboratory animal care and use committee of iwate university , iwate , japan .
eight clinically
healthy holstein bull calves , aged 10 3 weeks , were purchased from a government farm
( national livestock breeding center , morioka , japan ) and... | abstracteight holstein calves ( 10 3 weeks ) were used to examine the interaction between a
bacteria - based probiotic agent ( probiotic ) and the function of peripheral blood
mononuclear cells ( pbmcs ) .
the probiotic , consisting of lactobacillus
plantarum , enterococcus faecium and clostridium
butyricum ... |
an 18-month - old male patient , weighing 12 kg , was scheduled for removal of foreign body of the upper gastrointestinal tract using endoscopy under anesthesia on an outpatient basis .
the patient was delivered vaginally at 39 weeks gestational age , weighing 3,180 g. he was diagnosed with a tracheoesophageal fistul... | an 18 month - old boy underwent endoscopic foreign body removal under anesthesia on an outpatient basis and the operation took approximately 5 minutes .
stridor developed in both lung fields 6 hours after emergence from anesthesia , and severe croup developed , with cyanosis of the lips and aggravated stridor 20 hour... |
lynch syndrome , also known as hereditary nonpolyposis colorectal cancer ( hnpcc ) , is an autosomal dominant disorder associated with a germline mutation in one of the dna mismatch repair ( mmr ) genes , most commonly mlh1 and msh2 and less frequently msh6 and pms2 .
lynch syndrome is characterized by a strongly inc... | lynch syndrome ( hnpcc ) is a dominantly inherited disorder characterized by germline defects in dna mismatch repair ( mmr ) genes and the development of a variety of cancers , predominantly colorectal and endometrial .
we present a 44-year - old woman who was shown to carry the truncating msh2 gene mutation that had... |
india has a low public spending on health care , and the private out of pocket expenditure ( oope ) on health is one of the highest in the world .
one study estimated that 32.5 million people have fallen below the poverty line in 19992000 due to oope on health and overall poverty increased by 3.2% after accounting fo... | background : out of pocket expenditure ( oope ) for any illness is still a major problem in india .
several evidence is available regarding growing oope and its impact on household poverty
. however , limited evidence is there regarding oope on multiple disease conditions in public hospitals.aim:to estimate the oop... |
the korean society of nephrology has maintained an end - stage renal disease ( esrd ) registry since 1986 . however , serum mineral data have only been collected since 2012 . in 2013 , there were 59,918 dialysis patients registered by the korean society of nephrology ( hemodialysis , 52,378 ; peritoneal dialysis , 7,54... | the term ' chronic kidney disease - mineral bone disorder ' ( ckd - mbd ) is a new term that , in contrast to the old term ' renal osteodystrophy ' , implies a systemic syndrome associated with cardiovascular morbidity and mortality .
this new terminology is in line with previous studies that show elevated serum calc... |
is quinolinic acid ( quin or 2,3-pyridine - dicarboxylic acid ) an enemy at home ?
indeed , it could be : the presence of this endogenous molecule in the brain constitutes a major risk because under normal physiological conditions quin is a component of a major metabolic pathway of tryptophan degradation and can mo... | quinolinic acid ( quin ) , an endogenous metabolite of the kynurenine pathway , is involved in several neurological disorders , including huntington s disease , alzheimer s disease , schizophrenia , hiv associated dementia ( had ) etc .
quin toxicity involves several mechanisms which trigger various metabolic pathway... |
almost
40 years after the first report of their existence , intense
activity aimed at the chemical synthesis of the chlorosulfolipids
( 15 , figure 1 ) began independently and essentially simultaneously in at least
four research groups around the world .
apparently purely coincidental ,
this confluence of r... | a second - generation synthesis of
three structurally related chlorosulfolipids
has been developed .
key advances include highly stereocontrolled
additions to ,-dichloroaldehydes , kinetic resolutions
of complex chlorinated vinyl epoxide intermediates , and z - selective alkene cross metatheses of cis - vinyl... |
adenoid cystic carcinoma is a relatively rare epithelial tumor of the minor salivary glands that is clinically characterized by slow growth , high frequency of local recurrence and perineural invasion ( 1,2 ) .
the most common localization is the parotid gland , followed by the submandibular and sublingual glands ( 2... | adenoid cystic carcinoma is a rare neoplasm commonly originating from the minor salivary glands .
the clinical findings typical of this tumor include slow growth , perineural invasion and high frequency of local recurrence . in this study ,
a patient presented with a tongue base lesion that was treated with surgica... |
despite advances in therapies and health - care and increasingly sophisticated guidelines , sub - optimal diabetes control remains the norm in many countries with adverse consequences for the individual with diabetes and burgeoning costs for the wider health economy . over the last few years
, a greater understanding... | aims : the second diabetes attitudes , wishes and needs ( dawn-2 ) study assessed psychosocial issues and health - care provision of people with diabetes , their family members and health - care professionals.materials and methods : participants completed an online , telephone or in - person survey designed to assess h... |
bilateral diaphragmatic paralysis ( bdp ) manifests as respiratory muscle weakness , and prompt evaluation and management are important . however , in some cases , the diaphragm is the initial or the only muscle involved
. it can be myopathic or neuropathic in origin , although some cases are considered idiopathic , ... | abstractbilateral diaphragmatic paralysis ( bdp ) manifests as respiratory muscle weakness , and its association with critical illness polyneuropathy ( cip ) was rarely reported . here , we present a patient with bdp related to cip , who successfully avoided tracheostomy after diagnosis and management.a 71-year - old m... |
mutagenesis plasmid ptuc202 , which carries the mccj25
biosynthetic gene cluster ( 9 ) ,
was used as the template for site - directed mutagenesis .
mutagenesis was
performed with the quikchange site - directed mutagenesis kit ( stratagene ) in
the presence of 6% dmso . for each targeted codon ,
a pair ... | microcin j25 ( mccj25 ) is a 21-residue plasmid - encoded ribosomally
synthesized lariat - protoknot antibacterial peptide that targets bacterial rna
polymerase .
mccj25 consists of an 8-residue cycle followed by a 13-residue
tail that loops back and threads through the cycle .
we have performed
systema... |
hibernation is a behavioural and physiological adaptation of endothermic animals which enhances survival during extended seasonal periods of reduced food supply and low ambient temperature when core body temperatures can be close to 0c .
the ability to hibernate is found throughout the class mammalia and involves dif... | neurogenesis occurs in the adult mammalian hippocampus , a region of the brain important for learning and memory .
hibernation in siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h ( from 35 - 36c to + 46c ) permits accumulation of mitotic cells at diffe... |
limited hospital financial and personnel resources coupled with the need for established evidence - based clinical practice have forced surgeons and anaesthetists to consider appropriate triage for the immediate postoperative management of patients who have been subjected to major head and neck surgery .
poor nutriti... | critical care unit ( ccu ) beds are a limited resource and in increasing demand .
studies have shown that complex head and neck patients can be safely managed on a ward setting given the appropriate staffing and support .
this retrospective case series aims to quantify the ccu care received by patients following to... |
the self - organization of supramolecular structures driven by weak
intermolecular interactions is one of the most fascinating thermodynamic
phenomena in biology , chemistry , and physics .
because the interactions
are weak , many different structures can be formed with the same type
of building blocks . in b... | cryogenic transmission electron microscopy
( cryo - tem ) studies suggest
that ttbc molecules self - assemble in aqueous solution to form single - walled
tubes with a diameter of about 35 . in order to reveal the arrangement
and mutual orientations of the individual molecules in the tube , we
combine informa... |
mutations affecting the emd gene that encodes the inner nuclear membrane - associated protein emerin cause the x - linked form of emery - dreifuss muscular dystrophy ( edmd1 ) .
an indistinguishable disease phenotype ( edmd2 ) is caused by mutations in the lmna gene encoding lamin a / c .
the finding that the alter... | mutations in genes encoding nuclear envelope proteins , particularly lmna encoding the a - type lamins , cause a broad range of diverse diseases , referred to as laminopathies .
the astonishing variety of diseased phenotypes suggests that different mechanisms could be involved in the pathogenesis of laminopathies . i... |
although primary gastric lymphoma accounts for only 1% to 7% of all gastric malignant tumors , it constitutes approximately 60% of lymphomas of the gastrointestinal tract.1,2 gastric lymphoma occurs primarily in middle - aged patients ( age , 40 to 60 years ) , with no sex predilection.1 - 3 since isaacson and wright4 ... | mucosa - associated lymphoid tissue ( malt ) lymphoma of the stomach is the most common extranodal lymphoma of the gastrointestinal tract .
it is usually accompanied by helicobacter pylori infection , and eradication of h. pylori remains the mainstay of treatment for gastric malt lymphoma .
however , there is no co... |
in recent years , many malaria endemic countries around the world have made substantial progress in reducing their burden of the disease and 34 of 97 countries are in progress of malaria elimination and eight of them are as being in the malaria elimination phase .
effective malaria elimination efforts prevent malaria... | background : malaria elimination efforts face with substantial challenges and the role of health workers in address this challenge , particularly advocates and mobilizes communities .
the aim of the study was to explore perceptions of health workers in relation to eliminating malaria in order to better understand the... |
hsp70 has been shown to play an active role in oncogenic transformation and be abundantly expressed in most cancer cells .
plasma membrane hsp70 was demonstrated to act as a tumor - specific recognition structure for preactivated nk cells expressing high amounts of cd94 .
furthermore , the amount of membrane - boun... | nk cells represent a potential tool for adoptive immunotherapy against tumors .
membrane - bound hsp70 acts as a tumor - specific marker enhancing nk cell activity . using flow cytometry the effect of in vitro stimulation with il-2 or il-15 alone or in combination with hsp70-derived 14-mer peptide ( tkd ) on cell sur... |
kikuchi - fujimoto disease constituted 2.1% of 1724 lymph node biopsy specimens in a study published from tirupati and has been occasionally reported from india .
involvement of central nervous system ( cns ) is very rare in kikuchi - fujimoto disease .
we report this case of kikuchi - fujimoto disease with cns inv... | central nervous system involvement in kikuchi - fujimoto disease is a very rare clinical manifestation .
we report a 15-year - old girl who presented to us with fever , drowsiness , neck swellings , and involuntary closure of both eyelids of 2 days duration .
magnetic resonance imaging brain showed t2-weighted and ... |
a 74-year - old woman was referred to our emergency department because of pyrexia and productive cough for a few days .
she underwent replacements of three valves for mitral , tricuspid , and aortic regurgitation at 15 , 10 , and 2 years earlier .
vital signs showed blood pressure of 110/60 mmhg , temperature of ... | key clinical messageit is well - known that the major organisms for mycotic aneurysms are staphylococcus aureus , salmonella spp but is extremely rare in streptococcus pneumoniae in postantibiotic era .
we demonstrated the first case with multiple mycotic aneurysms simultaneously generated in the splenic and hepatic ... |
gastric cancer is the second leading cause of cancer - related death worldwide . in western countries ,
the incidence of gastric cancer has been decreasing , whereas it remains a main cause of cancer - related death in korea .
the incidence of ovarian metastasis or krukenberg tumor after curative resection of gastr... | purposethis study was conducted to validate the survival benefit of metastasectomy plus chemotherapy over chemotherapy alone for treatment of krukenberg tumors from gastric cancer and to identify prognostic factors for survival.materials and methodsclinical data from 216 patients with krukenberg tumors from gastric can... |
drug - induced hypersensitivity syndrome is a severe adverse drug reaction , which often manifests as an erythematous skin eruption , fever , lymphadenopathy , peripheral blood eosinophilia , and visceral organ involvement ( 1 ) .
many drugs cause hypersensitivity syndrome , including anticonvulsants , sulfonamides ,... | an 82-yr - old man was presented with fever and cough accompanied by generalized erythematous rash .
he had taken mexiletine for 5 months , as he had been diagnosed with dilated cardiomyopathy and ventricular arrhythmia .
laboratory studies showed peripheral blood eosinophilia and elevated liver transaminase levels... |
gliomas and glioneuronal tumors constitute the largest and most heterogeneous group of primary central nervous system tumors and diffuse astrocytic tumors ( who grades ii - iv ) comprise roughly 60% of all the primary intracranial tumors , with an annual incidence of 5 - 7/100,000 person - years .
glioblastoma ( gbm ... | background : though the tumor grade is a key factor influencing the choice of therapies , particularly determining the use of adjuvant radiation and specific chemotherapy protocols , role of abnormality in phosphatase and tensin homolog ( pten ) expression and variation in epidermal growth factor receptor ( egfr ) labe... |
in an early ana - world , sequence - independent electrostatic interactions between prebiotically - generated nucleic acids and peptides generate ana - fibers ( fig .
growth is driven by the recruitment of basic amyloidogenic peptides through interactions with uncompensated nucleic acid negative charges at fiber ends... | recent experimental support has been generated for a model of prebiotic development that postulates a role for amyloid - nucleic acid ( ana)-fibers as the earliest replicating entities capable of undergoing darwinian evolution . here , this new model is compared with existing rna - world models with a particular focus ... |
a healthy periodontal complex is the one which is capable of withstanding the stress of mastication , tooth brushing , trauma from foreign objects , tooth preparation associated with crown and bridge , subgingival restorations , orthodontics , inflammation , and frenulum pull .
a frenum is a small band or fold of muc... | anatomical aberrations and abnormalities are frequently associated with functional , psychosocial , and emotional problems .
one such aberration is crestal attachment of frenum or muscle on the alveolar processes of the jaws .
crestal attachment of buccinator muscle is a rare phenomenon , which may pose various pro... |
it occurs throughout the water column in deep oceans , and it exerts a significant impact on various biogeochemical cycles .
marinobacter aquaeolei is involved in redox reactions that utilize oxygen and nitrate as terminal electron acceptors .
it exhibits hydrocarbon - degrading mechanisms and is capable of diverse... | the trna structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process .
trna modification enzymes are prevalent in bacteria , archaea , and eukaryotes .
trna gm18 methyltransferase ( trmh ) and trna m1g37 methyltransfera... |
lowering blood pressure to values below 140/90 mm hg is of great value for patients with essential hypertension . for those with comorbidities such as diabetes mellitus or renal impairment ,
the target should even be lower , but with the available antihypertensive drugs , many patients either can not obtain full con... | electrical activation of the carotid baroreceptor system is an attractive therapy for the treatment of resistant hypertension . in the past
, several attempts were made to directly activate the baroreceptor system in humans , but the method had to be restricted to a few selected patients .
adverse effects , the nee... |
differentiated thyroid cancer ( dtcs ) account for 80% of all thyroid cancers and generally affected patients have a good prognosis .
while cancer - specific mortality of low risk ( tumor node metastasis [ tnm ] stage i ) patients is approximately 1% at 20 years , this increases to 2545% at 10 years after diagnosis... | objectives : the study was performed to evaluate the incremental value of single photon emission computed tomography / computed tomography ( spect / ct ) over planar radioiodine imaging before radioiodine ablation in the staging , management and stratification of risk of recurrence ( ror ) in differentiated thyroid can... |
in 1981 , i reported on the early results of knee replacement with a total condylar prosthesis in ninety - one patients who had advanced seropositive rheumatoid arthritis .
between 1975 and 1978 , 117 knee replacements were performed in ninety - one patients .
all of the patients had seropositive rheumatoid arthrit... | eighty knee replacements with a total condylar prosthesis in patients who had rheumatoid arthritis were followed for ten years . at ten years , nineteen knees needed revision and sixty - one prostheses were still functioning .
the major reasons for revision were loosening of the tibial component or late bacteremic se... |
studies using in vitro assay systems and biomarkers have proved mutagenic activity in air samples from urban and industrialized areas .
the international agency for research on cancer ( iarc ) classifies as carcinogens substances and compounds present in air emissions from industrial facilities such as some heavy met... | spatial aggregation of different industrial facilities leads to simultaneous release of pollutant emissions .
our objective is to study cancer mortality risk associated with residence in the vicinity of pollutant factories .
we used data on industries for year 2007 ( 3458 facilities ) . for the 8,098 spanish towns ... |
sildenafil is increasingly used off - label for treatment of pulmonary hypertension ( ph ) of various etiologies in infants and children .
persistent pulmonary hypertension of the newborn ( pphn ) and ph associated with congenital heart disease , chronic lung disease , or congenital diaphragmatic hernia are common co... | objectiveto examine the effect of sildenafil therapy on development of severe retinopathy of prematurity ( rop ) requiring surgical intervention in premature infants.study designwe identified premature infants who were discharged from pediatrix medical group neonatal intensive care units from 20032012 and who received ... |
there is growing evidence that breast lesions characterized by adenosquamous proliferation ( asp ) , whether in the form of a radial sclerosing lesion ( incorporating radial scar and complex sclerosing lesion ; rsl ) , a sclerosing papilloma or similar lesions , are phenotypically similar to lowgrade adenosquamous carc... | abstractwe sought to determine if adenosquamous proliferation of early cellular radial sclerosing lesions of the breast harbours hot spot mutations and to help clarify its relationship to lowgrade adenosquamous carcinoma as a potential form of early neoplasia .
four lowgrade adenosquamous carcinomas , early radial sc... |
caud is classified into saccular variety and globular variety , the former being more common than the latter .
the cause and effect relationship between anterior urethral diverticulum ( aud ) and anterior urethral valve ( auv ) has been extensively debated .
some authors do not distinguish between aud and auv , whi... | congenital anterior urethral diverticulum ( caud ) is an uncommon condition in children .
we describe 2 patients of caud who presented with ventral penile swelling ; in one , the site of swelling was just proximal to corona which is quite rare .
the diagnosis was made on usg and mcu .
both patients had normal r... |
postoperativeadhesions are almost inevitable after most abdominal surgeries . the severity and extent of adhesions are , however , variable , and , fortunately , the majority of adhesions do not manifest clinically . in spite of this , adhesive intestinal obstruction is common in adults and considered the second caus... | objectives . adhesive intestinal obstruction ( aio )
is rare in the pediatric age group and its treatment is still controversial .
this is a retrospective review of our experience in infants and children with aio .
patients and methods .
the records of infants and children with aio between january 2001 and dece... |
gastric and gastroesophageal junction ( gej ) adenocarcinoma is an aggressive disease with a 5-year survival rate of 5 - 20% in advanced disease 1 . the international trastuzumab for gastric cancer ( toga ) trial demonstrated that patients with human epidermal receptor 2 ( her2 ) overexpressing tumours benefit from tar... | therapy with trastuzumab confers a survival benefit in her2 positive advanced gastric and gastroesophageal adenocarcinoma .
her2 status is evaluated by immunohistochemistry ( ihc ) and in situ hybridization ( ish ) .
an ish ratio of her2 to centromere 17 ( cep17 ) 2.0 is considered amplified .
this assumes that c... |
type i neurofibromatosis , also referred to as von recklinghausen s disease , is an autosomal dominant disease characterized by neurofibromas and abnormal cutaneous pigmentation ( cafe - au - lait spot ) .
its malignant transformation , that is malignant peripheral nerve sheath tumor ( mpnst ) , accounts for about 51... | malignant peripheral nerve sheath tumor ( mpnst ) is defined as any malignant tumor arising from or differentiating toward the cells of the peripheral nerve sheath .
mpnst accounts for about 510% of all soft tissue tumors and is often associated with neurofibromatosis type i ( nf-1 , von recklinghausen s disease ) . ... |
the south sudan ministry of health and world health organization implemented a clinic - based cholera surveillance system that captured basic patient data , laboratory results ( if available ) , and outcomes .
a suspected cholera case - patient was defined as anyone with acute watery diarrhea ( diagnosed by a clinici... | following mass population displacements in south sudan , preventive cholera vaccination campaigns were conducted in displaced persons camps before a 2014 cholera outbreak .
we compare cholera transmission in vaccinated and unvaccinated areas and show vaccination likely halted transmission within vaccinated areas , il... |
antiretroviral therapy ( art ) plays an important role in the management of hiv - positive patients to prevent the disease progression , further immunosuppression , and the great amount of mortality and morbidity associated with the disease .
nvp is most commonly used non - nucleoside reverse transcriptase inhibitor ... | aims and objectives : to study the change in the incidence and pattern of nevirapine ( nvp)-induced adverse cutaneous reactions ( adr ) after commencement of revised national aids control organisation ( naco ) guidelines for initiation of antiretroviral therapy ( art ) since nov 2011.materials and methods : the study w... |
anxiety disorders ( ads ) are the most common type of psychiatric disorders , with a mean incidence of 18.1% and a lifetime prevalence of 28.8% ( kessler et al 2005 ) .
ads results in a great economic burden as it was estimated that they account for a $ 42.3 billion annual cost in the united states , with over 50% of... | anxiety disorders ( ads ) are the most common type of psychiatric disorders , with a mean incidence of 18.1% and a lifetime prevalence of 28.8% .
pharmacologic options studied for treating ads may include benzodiazepines , tricyclic antidepressants ( tca ) , selective serotonin reuptake inhibitors ( ssris ) , noradre... |
raves are parties with loud , electronic techno - rock music , laser light shows , and all - night dancing held in clandestine locations , including warehouses , nightclubs , and farm fields1 .
the underground or noncommercial music featured at raves which is produced by computers and include little or no vocals is... | club drugs which include ecstasy , gamma - hydroxybutyrate ( ghb ) , ketamine , and rohypnol ( flunitrazepam ) have become popular with participants in raves , because they are perceived to enhance energy , endurance , sociability and sexual arousal .
these drugs vary in their pharmacologic properties , physiologica... |
the exposure of cultured rat hepatocytes to mono(2-ethylhexyl)phthalate ( mehp ) for 72 hr resulted in marked induction of peroxisomal enzyme activity ( beta - oxidation ; cyanide - insensitive palmitoyl coa oxidase ) and concomitant increases in the number of peroxisomes .
similar treatment of cultured guinea pig , ... | |
critical limb ischemia ( cli ) , a severe condition of perfusion insufficiency in the lower extremities , commonly leads to peripheral artery occlusive disease ( paod ) .
cli is often caused by atherosclerosis related to hypertension , diabetes , or smoking ; to date , no effective medical therapy is available for cl... | abstractperfusion difference is used as a parameter to evaluate microcirculation . this study aims to differentiate lower - limb perfusion insufficiency from neuropathy to prevent possible occurrence of failed back surgery syndrome ( fbss).patients were retrospectively gathered from 134 fbss cases diagnosed in the past... |
pulmonary tumor thrombotic microangiopathy ( pttm ) is an uncommon , fatal , malignancy - related complication causing marked pulmonary hypertension , right heart failure , and death .
tumor emboli in the vasculature with consequent local activation of coagulation and by widespread fibrocellular intimal proliferation... | pulmonary tumor thrombotic microangiopathy ( pttm ) is a rare , malignancy - related complication that causes marked pulmonary hypertension , right heart failure , and death .
we report on a patient with locally advanced breast cancer whose course was complicated by fatal pttm based on clinical and laboratory finding... |
there have been major changes in accepting medical sciences students , including nursing students , in the university entrance examinations around the world in recent years .
now it is widely accepted that university students should not only fit their future profession in all aspects but also have enough knowledge an... | background : understanding why the graduates from the high schools choose nursing is essential for the health policy makers in each country and iran is not an exception . the aim of this study was to develop an instrument measuring the influential factors on career choice among iranian nursing students.materials and me... |
in ontario , canada , the routine pediatric immunization schedule includes vaccines against diphtheria , pertussis , tetanus , polio , hemophilus influenzae type b ( hib ) and pneumococcus administered at 2 , 4 and 6 mo of age , and vaccines against measles , mumps and rubella ( mmr vaccine ) and meningococcal disease ... | using a population - based self - controlled case series design , we examined data on children born between the years 2002 and 2009 in the province of ontario , canada .
we specifically examined how socioeconomic status ( ses ) influences rates of adverse events following immunization ( aefi ) , defined as emergency ... |
aging and weight loss have visible effects on the skin . structural changes to the skin associated with aging , such as changes in fat distribution and loss of collagen and elastic fibers , cumulate in a loss of tone and elasticity and manifest as wrinkles.1,2 substantial weight loss has also been shown to be associate... | backgroundthe objective of this study was to investigate the efficacy , safety , and subject satisfaction of the calcium hydroxylapatite - based dermal filler radiesse in a novel body vectoring technique to correct skin flaccidity in the thighs , abdomen , and brachial zones.methodsfemale subjects with self - evaluated... |
allergic rhinitis ( ar ) is an upper airway disease that 's caused by an ige - mediated inflammatory reaction after allergen exposure ( 1 ) , and it could contribute to decreased social activity , a poor quality of school life and decreased productivity in moderate - to - severe symptomatic patients ( 2 - 4 ) .
its i... | objectivesthe allergic rhinitis and its impact on asthma ( aria ) guidelines were suggested for use to classify allergic rhinitis ( ar ) .
however , few studies have been performed in asians .
the objective of this study is to identify the clinical characteristics of ar in korean patients according to the aria guid... |
they most commonly affect men in their elderly 60s and occur in the upper respiratory tract ( paranasal sinuses , nose , nasopharynx , and tonsils ) .
they also occur in lymph nodes , lung , thyroid , gastrointestinal tract , liver , spleen , pancreas , testes , breast , or skin ( 2 ) .
although extramedually plasm... | extramedullary plasmacytoma of the liver is a very rare tumor .
although a few cases of extramedullary plasmacytoma of the liver have been reported , we could not find any report on truly localized extramedullary plasmacytoma of the liver in the literature .
the patient was a 63-yr - old man who exhibited a solitar... |
samples were purchased from grocery stores , health food shops , and pharmacies in norway .
all stores were located in oslo and akershus , two densely populated counties in norway .
it was attempted to purchase at least three different products of the same type of vegetable oil ( e.g. at least three different produ... | backgroundthere is convincing evidence that replacing dietary saturated fats with polyunsaturated fats ( pufa ) decreases risk of cardiovascular diseases .
therefore , pufa rich foods such as vegetable oils , fatty fish , and marine omega-3 supplements are recommended .
however , pufa are easily oxidizable and ther... |
nutrition is the first need of man ; his general health and well being are much dependent on his nutritional status . nutritional deficiency disorders
the most commonly occurring disorders are those associated with protein calorie malnutrition or with vitamin deficiencies . among the vitamin deficiencies , vitamin a ... | this case reports a rare condition of scurvy which posed a diagnostic difficulty .
however , a thorough medical and diet history , along with clinical and histopathological examination aided in prompt diagnosis and successful management of the case .
occurrence of scurvy in today 's contemporary society is said to ... |
central to the way featureextract processes annotation information is a simple but powerful concept the use of an annotation string , which is a string of characters the same length as the dna string .
this is best illustrated by a short example showing how the start of the yeast gene ybr062c will be annotated :
... | work on a large number of biological problems benefits tremendously from having an easy way to access the annotation of dna sequence features , such as intron / exon structure , the contents of promoter regions and the location of other genes in upsteam and downstream regions .
for example , taking the placement of i... |
it remains unclear how cardiac resynchronization therapy ( crt ) improves symptom status in heart failure population .
crt is one of the major treatment for patients suffering from refractory heart failure ( hf ) despite an optimal drug regimen .
huge previous trialsconfirmed improvement in both symptom status ( ny... | background . changes in peripheral muscle in heart failure lead to a shift from aerobic to early anaerobic metabolism during exercise leading to ergoreflex overactivation and exaggerated hyperventilation evaluated by the ve / vco2 slope . methods .
50 patients ( 38 males , 59 12 years ) performed cardio - pulmonary ... |
odontogenic ghost cell carcinoma ( ogcc ) is a rare odontogenic tumor characterized by the presence of ghost cells .
it can appear as a de novo tumor or may arise in a preexisting calcifying odontogenic cyst ( coc ) .
until now , only 31 cases of ogccs have been reported in literature . because of the limited numbe... | odontogenic ghost cell carcinoma ( ogcc ) is an exceptionally rare malignant odontogenic epithelial tumor .
it is characterized by ameloblastic - like islands of epithelial cells with aberrant keratinization in the form of ghost cells with varying amounts of dysplastic dentin .
malignant histological characteristic... |
hepatitis b ( hb ) vaccine is highly immunogenic and efficacious in preventing hepatitis b virus ( hbv ) infection ( 1 - 6 ) .
long - term protection by hb vaccination is dependent on the persistence of strong immunologic memory ( 7 - 11 ) .
immune memory is a key characteristic of specific immune response and resi... | background : the long - term duration of cell - mediated immunity induced by neonatal hepatitis b virus ( hbv ) vaccination is unknown.objectives:study was designed to determine the cellular immunity memory status among young adults twenty years after infantile hb immunization.patients and methods : study subjects were... |
hemiplegic shoulder pain ( hsp ) is one of the most common complications after acute stroke .
a stroke patient with a flaccid shoulder also has a high likelihood of experiencing hsp during rehabilitation and daily life .
hsp has negative effects on poststroke functional recovery , activities of daily living , quali... | abstractbackground : hemiplegic shoulder pain ( hsp ) is one of the most common comorbidities in stroke patients with flaccid shoulders .
the pain limits functional motor recovery and affects the activities of daily living after acute stroke .
this study investigated the effects of hyaluronic acid ( ha ) injection ... |
mitochondria are double - membrane cytoplasmic organelles essential for energy supply to the cell . adenosine-5-triphosphate ( atp ) ,
the molecular unit of currency for intracellular energy transfer , is produced by the last of five multisubunit complexes embedded in the inner mitochondrial membrane , which form the... | mitochondrial respiratory chain ( rc ) disorders are a group of genetically and clinically heterogeneous diseases .
this is because protein components of the rc are encoded by both mitochondrial and nuclear genomes and are essential in all cells .
in addition , the biogenesis and maintenance of mitochondria , inclu... |
in recent years the
focus in proteomics has shifted from cataloging
the parts list of gene products inside the cell toward
understanding the structural and functional properties of proteins
in a systematic and high - throughput manner .
a key step toward this goal is the comprehensive characterization
of ... | the
conjugation of complex post - translational modifications ( ptms )
such as glycosylation and small ubiquitin - like modification ( sumoylation )
to a substrate protein can substantially change the resulting peptide
fragmentation pattern compared to its unmodified counterpart , making
current database sear... |
all animals were anesthetized with an intraperitoneal injection of 1 g / kg body weight ( b.w . )
five mice had a polyethylene ( pe50 ) catheter with an adapted tip ( eppendorf , 0030 001.222 ) inserted into a femoral vein . through this catheter , a 15 mmol / l mncl2 solution ( in 0.9% nacl ) was infused at the rate... | objectivewe studied whether manganese - enhanced high - field magnetic resonance ( mr ) imaging ( mehfmri ) could quantitatively detect individual islets in situ and in vivo and evaluate changes in a model of experimental diabetes.research design and methodswhole pancreata from untreated ( n = 3 ) , mncl2 and glucose -... |
the whitehall ii cohort is an ongoing study of british civil servants . at study inception ( 19851988 ) , 10,308 participants ( 67% men , age range 3555 years ) underwent a clinical examination and completed a self - administered questionnaire .
all participants provided written informed consent , and the university ... | objective : to examine the association between alcohol consumption in midlife and subsequent cognitive decline.methods:data are from 5,054 men and 2,099 women from the whitehall ii cohort study with a mean age of 56 years ( range 4469 years ) at first cognitive assessment .
alcohol consumption was assessed 3 times in... |
posterior inferior cerebellar artery ( pica ) aneurysms comprise 1% of all intracranial aneurysms , which are usually located at the vertebral artery ( va)-pica junction or just distal to it .
the pica is well known for its varied anatomical origin and course , originating below the foramen magnum in 18% normal arter... | extracranially located posterior inferior cerebellar artery ( pica ) aneurysms are rare with only 21 cases reported till date .
they may arise either from the proximal segment of an extracranially originating pica or from the tip of its caudal loop when it dips below the foramen magnum .
a 16-year - old female pres... |
igg4-related disease is a newly recognized fibroinflammatory condition characterized by tumefactive lesions , a dense lymphoplasmacytic infiltrate rich in igg4-positive plasma cells , storiform fibrosis , often but not always elevated serum igg4 concentration and a favorable response to steroids ( stone et al . , 2012 ... | igg4-related disease is a newly recognized systemic disease characterized by involving a wide range of organs .
it includes the pancreas , biliary tree , salivary glands , periorbital tissues , upper aerodigestive tract , retroperitoneum , mediastinum , aorta , soft tissue , skin , central nervous system , breast , k... |
pituitary tumors are second frequently diagnosed primary cns tumors in both korea and the unites states1523 ) . the conventional classifications are based on the size and functional status of tumors .
furthermore , several other classifications of suprasellar extension and parasellar extension of pituitary adenomas h... | objectivethe inter - rater reliability of the modified knosp 's classification was measured before the analysis .
the clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal... |
acetaminophen ( apap , 4-hydroxyacetanilide ) , a nonsteroidal analgesic and antipyretic drug , is used for the treatment of a variety of arthritic and rheumatic conditions with musculoskeletal pain and in other painful disorders such as headache , dysmenorrhea , myalgia , and neuralgia .
it is also indicated in cond... | acetaminophen ( apap ) is a widely used analgesic and antipyretic drug , but at high dose it leads to undesirable side effects , such as hepatotoxicity and nephrotoxicity .
the aim of this study was to evaluate the protective role of ddm - gsh , a mixture of l - cysteine , l - methionine , and l - serine in a weight ... |
leiomyosarcoma ( lms ) of the inferior vena cava ( ivc ) is a slowly developing tumor which arise from smooth muscle cells of the wall of ivc in 38% cases.1 this tumor reside at the level of segment i represented by sub - renal ivc in 38% cases.2
a 50-year old patient , with no previous medical history , consulted fo... | vascular leiomyosarcoma ( lms ) are unique .
the inferior vena cava ( ivc ) is the most affected organ ( about 38% cases ) .
we report the observation of a 50-year old woman who consulted for right upper quadrant pain .
imaging studies revealed a retroperitoneal mass that mimic a lms of the ivc .
the patient wa... |
to report a case of orbital capillary hemangioma in an adult who was successfully treated with topical timolol maleate 0.5% solution .
we report an adult patient with a relatively large orbital capillary hemangioma who was successfully treated with a topical -blocker solution
. this treatment might be applica... | purposeto report a case of orbital capillary hemangioma in an adult who was successfully treated with topical timolol maleate 0.5% solution.methodscase report.resultsa 43-year - old female presented both superficial and deep orbital capillary hemangioma .
topical timolol maleate was applied twice daily .
the superf... |
first described by kaijser in 1937 , eosinophilic enteritis is an uncommon gastrointestinal disorder characterized by symptoms of abdominal pain and partial obstruction .
laparotomy and biopsy reveals pathologic findings of eosinophilic infiltration of bowel wall in the absence of parasitic or extraintestinal disease... | as the popularity of laparoscopic cholecystectomy continues to grow , evaluation of patients with documented cholelithiasis and concomitant vague abdominal complaints becomes less rigorous .
we present the case of a patient with chronic cholecystitis documented by history and ultrasonography , incidentally noted on l... |
the cardia study is an ongoing , prospective , multicenter , observational study of the natural history of the development of cardiovascular disease risk from young adulthood to midlife . in 1985 ,
5,115 young adults between the ages of 18 and 30 years were randomly selected from four u.s .
cities : birmingham , al... | objectivealthough hyperinsulinemia , a surrogate of insulin resistance , may play a role in the pathogenesis of hypertension ( htn ) , the longitudinal association between fasting insulin level and htn development is still controversial .
we examined the relation between fasting insulin and incidence of htn in a larg... |
facial pain may be due to many etiologies , including neurological , vascular , or dental in origin .
patients will often make the first attempt at diagnosis in that he or she chooses to consult either a dentist or the primary doctor .
neurological and vascular causes of facial pain are rare compared to dental and ... | the etiologies of facial pain are innumerable , thus facial pain misdiagnosis and resultant mismanagement is common .
numb chin syndrome presents with hypoesthesia and/or anesthesia in the dermatomal distribution of the inferior alveolar or the mental nerve . in this case report
, we will discuss a case of intracta... |
it is formed by the rami of the ischium and the pubic bone . the foramen is partially closed by a strong musculoaponeurotic barrier consisting of an internal and an external obturator membrane and an internal and an external obturator muscle .
the obturator canal is situated in the cranial portion of this membrane wi... | background : we performed a pilot study review of 7 female patients suffering with obturator neuralgia produced by a type i obturator hernia .
diagnosis and laparoscopic treatment of this rare hernia are presented.methods:patients with chronic pelvic pain and signs of obturator neuralgia were identified retrospective... |
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