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the use of accurate static references for centration , the improvement of accuracy of wavefront aberration measurements , and the refinement of ablation profiles are technological advances that have led the corneal refractive surgery to a high level of efficacy , predictability , and accuracy.13 specifically , these ad... | purposethe purpose of this study was to evaluate the visual , refractive , and aberrometric outcomes as well as the level of patient satisfaction and photic phenomena after myopic laser in situ keratomileusis ( lasik ) surgery using wavefront - guided ( wfg ) ablations based on measurements obtained with a high - resol... |
in different eukaryotic cells , glycosylated and non - glycosylated er - luminal as well as integral membrane proteins have been identified as erad substrates . based on the location of the misfolded lesion in the protein that is subjected to disposal , eradl ( lesion in the luminal region ) , eradc ( defect in the cyt... | in all eukaryotes the endoplasmic reticulum ( er ) has a central role in protein folding and maturation of secretory and membrane proteins . upon translocation into the er polypeptides are immediately subjected to folding and modifications involving the formation of disulfide bridges , assembly of subunits to multi - p... |
the last two decades have been subject to an increase in social awareness regarding the rights of all workers about workplace health and safety .
the laws and regulations in this area were established to protect workers and increase their welfare in the workplace .
irrespective of the context of the work environmen... | background : healthcare professionals encounter many medical risks while providing healthcare services to individuals and the community .
thus , occupational safety studies are very important in health care organizations . they involve studies performed to establish legal , technical , and medical measures that must ... |
the ocean components of the coupled model intercomparison project phase5 ( cmip5 ) global climate models ( gcms or climate models ) used by the intergovernmental panel on climate change ( ipcc ) to publish their fifth assessment report have a coarse resolution ( on the scale of 1 ) ( frieler et al .
this coarse res... | abstractprojections of climate change impacts on coral reefs produced at the coarse resolution ( ~1 ) of global climate models ( gcms ) have informed debate but have not helped target local management actions . here , projections of the onset of annual coral bleaching conditions in the caribbean under representative co... |
cancer of the gastric stump in patients previously operated on for benign disease was first mentioned by balfour in 1922 and was subsequently described by several authors . today
, cancer of the gastric stump is no longer the great rarity it was once considered to be . although the question whether gastric resection ... | carcinoma of the gastric stump as a late complication for resection of benign disease is a well recognized clinical entity.the risk of stump carcinoma , at least in western europe , is estimated to be increased twofold compared with the normal population.but in korea there has been one report .
recently we experience... |
obesity is regarded as a medical condition characterized by excessive accumulation of body fat to the extent that it has an adverse effect on health .
body mass index ( bmi ) , waist - hip ratio and body fat percentage are different measures used to identify obesity .
an index of less than 18.5 can be considered un... | abstractobjectivesthe purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre - maternal obesity / overweight when compared with pre - maternal normal weight women.material and methodsmedline and embase were searched from 1980 to july 2014 for cohort , case control and cross ... |
animal studies and case reports have suggested that methylphenidate ( mph ) exerts adverse effects on the reproductive system or gonadal hormones .
however , it is unclear whether mph treatment reduces testosterone levels in children with attention - deficit / hyperactivity disorder ( adhd ) . in this prospective stu... | abstractbackground : animal studies and case reports have suggested that methylphenidate exerts adverse effects on gonadal hormones .
this study aimed to determine whether methylphenidate alters testosterone levels in children with attention - deficit / hyperactivity disorder through comparison of those with or witho... |
malaria remains a serious health concern in sub - saharan africa . in cte d'ivoire , malaria accounts for 43% of outpatient visits with one - third of reported death in health facilities . due to the development and increasing resistance of p. falciparum to various antimalarial drugs available , the who introduced and ... | two years after the introduction of free artesunate - amodiaquine ( asaq ) and artemether - lumefantrine ( al ) for the treatment of uncomplicated malaria in public health facilities in cte d'ivoire , we carried out this study to compare their efficacy and tolerability in three surveillance sites .
it was a multicent... |
a 46-year - old woman presented with intermittent right flank pain she had experienced for a year .
physical examination revealed no significant findings such as tenderness at the costovertebral angle area , a palpable mass , or peripheral lymphadenopathy .
urinalysis , a complete blood count , and routine blood bi... | mesenteric fibromatosis is a rare benign disease characterized by proliferating fibrous tissue in the bowel mesentery .
we report a case of aggressive mesenteric fibromatosis with ureteral stenosis arising in a 46-year - old woman who suffered from intermittent right abdominal pain .
computed tomography revealed a ... |
the shs recruited a population based sample of 4,545 unrelated tribal members 45 year or older without regard to disease status from 13 tribal communities in arizona , oklahoma and north and south dakota .
this study uses data from a clinical visit in 198991 , which is the shs visit that has measures of urinary cadmi... | cadmium is an environmental pollutant that has been associated with cardiovascular disease in populations , but the relationship of cadmium with hypertension has been inconsistent .
we studied the association between urinary cadmium concentrations , a measure of total body burden , and blood pressure in american indi... |
serious side effects hamper pharmacological treatment of psychiatric illnesses such as schizophrenia and bipolar disorder .
all currently used second - generation antipsychotic drugs ( sgads ) including olanzapine are capable of triggering significant weight gain associated with adverse metabolic alterations [ 1 , 2 ... | experiments were performed in 3t3-l1 preadipocytes differentiated in vitro into adipocytes .
cells were treated with olanzapine and a 5-lipoxygenase ( 5-lox ) activating protein ( flap ) inhibitor mk-886 .
lipid content was measured using an oil red o assay ; 5-lox and flap mrna content was measured using quantitat... |
stable dispersion of sub - micron solid particles in polymer melts and solutions can be achieved in the presence of favorable polymer particle interactions . studying the rheological behavior of polymer composites reinforced with well - dispersed nanoparticles , often referred to as polymer nanocomposites ( pncs ) , h... | a scaling model is presented to analyze the nonlinear rheology of unentangled polymer melts filled with high concentration of small spherical particles . assuming the majority of chains to be reversibly adsorbed to the surface of the particles , we show that the emergence of nonlinearity in the viscoelastic response of... |
genomic guanine cytosine ( gc ) content in prokaryotes has been studied for > 50 years . since the pioneering works , which began in 1955
the first considerations of gc content evolution speculated on the absence of a selective force behind this pattern of gc content variability ( sueoka 1962 ) , a vision that was ... | one of the historic debates in molecular evolution concerns the strong variation in the genomic guanine cytosine ( gc ) content of prokaryotes , which ranges from approximately 2075% : is this factor selectively neutral , or is it the result of natural selection ? in a previous article published by our group , we show... |
epidural anesthesia is the most commonly used technique for providing not only peri - operative surgical anesthesia but postoperative analgesia in lower abdominal and limb surgeries .
many techniques and drug regimens , with partial or greater success , have been tried from time to time to calm the patients and to el... | background and aims : alpha ( -2 ) adrenergic agonists have both analgesic and sedative properties when used as an adjuvant in regional anesthesia .
a prospective randomized double - blind study was carried out to evaluate the efficacy of epidural route and to compare the efficacy and clinical profile of dexmedetomid... |
expertise in the field of root canal morphology is crucial for successful endodontic treatment . to avoid endodontic failure , especially during root canal preparation and/or obturation
, the practitioner must have ample knowledge of the root morphology . due to each tooth 's singularity ,
such characteristics incr... | the aim of this study was to investigate the root canal configuration , accessory canals and number of main foramina of 123 maxillary second molars by means of micro - computed tomography .
the teeth were scanned and reproduced with 3d software imaging .
the root canal configuration and number of main foramina were... |
genetic screening of the brca1 and brca2 genes is offered to families with high risk of breast and ovarian cancer . besides clear
pathogenic mutations and polymorphisms , unclassified variants ( uvs ) of unclear clinical relevance are found .
some of these uvs may result in aberrant splicing , by affecting the dono... | a rapid and easy method to screen for aberrant cdna would be a very useful diagnostic tool in genetics since a fraction of the dna variants found affect rna splicing .
the currently used rt - pcr methods require new primer combinations to study each variant that might affect splicing .
since mlpa is routinely used ... |
protein production production and purification of
recombinant human tpp1 from a chinese hamster ovary ( cho )
expression system
were conducted using modifications of methods described previously
( 9 ) .
cells were cultured in
1050-cm roller bottles for 9 days with serum - free dulbecco 's
modified e... | late infantile neuronal ceroid lipofuscinosis is a fatal childhood
neurological disorder caused by a deficiency in the lysosomal protease
tripeptidyl - peptidase 1 ( tpp1 ) .
tpp1 represents the only known mammalian
member of the s53 family of serine proteases , a group characterized by a
subtilisin - lik... |
obesity is traditionally defined as a weight 20% above the ideal weight , which corresponds to the lowest death rate for individuals of a specific height , gender and age ( 1 ) .
more recent guidelines for obesity have introduced the use of a measurement known as body mass index ( bmi ) , which is calculated by the i... | the imbalance between energy intake and expenditure is the main cause of excessive overweight and obesity .
technically , obesity is defined as the abnormal accumulation of 20% of body fat , over the individual 's ideal body weight .
the latter constitutes the maximal healthful value for an individual that is calcu... |
women diagnosed with gynaecological cancer are at risk for depression , anxiety and impaired quality - of - life ( qol ) even after treatment . , , , overall survival and hrqol are important components of assessing the effects anti - cancer treatment .
post - radiotherapy qol is not only depends upon the clinical var... | background : cancer specific survival and quality - of - life ( qol ) assessment are important in evaluating cancer treatment outcomes .
baseline demographic profiles have significant effects on follow - up health related qol ( hrqol ) and affect the outcome of treatments.materials and methods : post - operative gyna... |
hypersexual disorder is primarily conceptualized as a disorder of sexual desire , with an impulsivity component .
it has symptoms befalling impulsive , compulsive , and addiction domains such as recurrent and intense sexual thoughts , urges , or behaviors , inability to control or stop the sexual behavior , and repet... | hypersexual disorder has phenomenological resemblance with impulsive - compulsive spectrum disorders .
inhibitory repetitive transcranial magnetic stimulation ( rtms ) over the supplementary motor area ( sma ) has been found to be effective in the management of impulsive - compulsive behaviors .
inhibitory rtms ove... |
hepatosplenic t cell lymphoma ( hstl ) is a rare but very aggressive peripheral t cell lymphoma whose initial silent clinical presentation unfortunately delays the diagnosis and worsens the prognosis of patient survival .
we describe a case of a 62-year - old woman who presented at our clinic with a non - palpable pu... | backgroundhepatosplenic t cell lymphoma ( hstl ) is a rare but very aggressive peripheral t cell lymphoma whose initial silent clinical presentation unfortunately delays the diagnosis and worsens the prognosis of patient survival .
efforts should be aimed at early recognition and treatment.methodswe describe a case o... |
a series of data has accumulated over the past five years that raises questions about our current understanding of the
transcriptional process and its regulation . following the discovery of coactivators for nuclear receptors ( nrs ) , we have been
amazed at the plethora of these molecules that have been re... | a series of data has accumulated over the past five years that raises questions about our current understanding of
the transcriptional process and its regulation . following the discovery of coactivators for nuclear receptors ( nrs ) ,
a
large number of these molecules have been reported in the litera... |
hyaluronic acid is a suitable tool for lip augmentation and reduction of fine lines ; however , one must be aware of anatomic structures when injecting filler material into the lips and perioral area , and be familiar with the injection techniques .
to increase the volume of the lips , a procedure called lip augmenta... | aimto investigate the exact location and position of hyaluronic acid fillers in the perioral region by ultrasound and optical coherence tomography.introductionto date , there are few in vivo investigations in humans on the exact positioning of injectable hyaluronic acid fillers , and severe complications such as hemato... |
charcot - marie - tooth ( cmt ) , also known as hereditary motor and sensory neuropathy , is classified into two major categories : type 1 and type 2 based on the value of motor median nerve conduction velocity ( ncv ) .
cmt1 , also known as the demyelinating form of cmt , is clinically characterized by slow ncvs due... | charcot - marie - tooth ( cmt ) disease is a clinically and genetically heterogeneous group of disorders affecting both motor and sensory neurons in the peripheral nervous system .
mutations in the mfn2 gene cause an axonal form of cmt , cmt2a .
the v705i variant in mfn2 has been previously reported as a disease - ... |
tumor - bearing animals offer a variety of xenograft - based cancer models may greatly help understanding cancer biology , especially for the interactions among cancer cells and normal cells in vivo situation . for this purpose
the need of tumor - bearing animal models that can be elucidating the behaviour of cancer ... | physiological responses such as chronic inflammation and angiogenesis could be used as biomarkers for early detection of cancer with noninvasive imaging modalities .
the present study reports the application of magnetic resonance imaging instrument to image the binding of ferrioxamine with hemin that allows visualizi... |
the next volume of the international journal of telerehabilitation will be published in fall , 2014 .
we cordially invite your submissions by october 1 , 2014 and accept original research , case studies , viewpoints , technology reviews , book reviews , and country reports that detail the current status of telerehabi... | the spring 2014 issue of the international journal of telerehabilitation ( ijt ) contains four informative and timely policy articles : ( 1 ) an invited commentary describing the exploratory process underway within physical therapy to create licensure portability for physical therapists , ( 2 ) an analysis of state tel... |
fgm / c is the incomplete or complete removal of female external genital organs for nontherapeutic reasons ( 1 ) .
at least 140 million females today are estimated to have suffered fgm / c ( 2 ) , and approximately 3 million women , including young females , every year are at risk of undergoing this procedure ( 3 ) .... | introductionfemale genital mutilation / cutting ( fgm / c ) is globally recognized as a violation of the human rights of females .
it has no health benefits and harms those who undergo the procedure .
midwives are therefore expected to be aware of how to manage these consequences and play a key role in the preventi... |
schistosomatidae ( platyhelminthes : digenea ) includes several digenetic endoparasites with complex life cycles , whose developmental stages alternate between intermediate ( freshwater gastropods ) and definitive hosts ( birds , reptiles , fishes , and mammals ) .
another important feature is the increased longevity... | schistosomes are digenean blood flukes of aves and mammals comprising 23 species .
some species are causative agents of human schistosomiasis , the second major neglected disease affecting over 230 million people worldwide .
modern technologies including the sequencing and characterization of nucleic acids and prot... |
clinical studies have demonstrated that increased level of inflammatory parameters related to acute phase reaction such as interleukin-6 or c - reactive protein ( crp ) predicts unfavorable outcome in ischemic stroke patients ( reviewed in ) .
hyperfibrinogenemia in acute cerebral ischemia is associated with increase... | hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome .
we hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently of baseline fibrinogen concentration .
we included 266 patients with first - ever ischemic stroke in whom plasma fib... |
a man in his eighties with a past medical history notable for 4 primary cutaneous melanomas ( all ajcc stage ia or 0 ) , squamous cell skin cancer , and severe actinic damage presented for routine skin cancer surveillance follow - up . on the left dorsal forearm ,
a new 8 mm bluish nodule was detected during photogra... | colonization of basal cell carcinoma ( bcc ) by melanoma cells is a unique and uncommonly reported cutaneous entity .
we describe a bluish nodule on the left forearm found during routine skin cancer surveillance examination with suspicious dermatoscopic findings including central - blue - white veil , sparse atypical... |
it is increasingly recognized that health workers , especially nurses and nursing technicians , are subject to a variety of health hazards .
several studies have indicated the need to identify , in a critical area such as an icu , the factors causing hazards , as well as strategies to avoid them , so that the health ... | this study analyzed occupational health hazards for intensive care unit ( icu ) nurses and nursing technicians , comparing differences in the number and types of hazards which occur at the beginning and end of their careers .
a descriptive cross - sectional study was carried out with 26 nurses and 96 nursing technici... |
bronchogenic cysts are congenital lesions that originate from the tracheobronchial tree in the sixth week of gestation .
their usual site is middle mediastinum , but infrequently these have been reported to present as a subcutaneous swelling or sinus .
a 3-year - old healthy male child born to non - consanguineous ... | bronchogenic cysts occur due to the anomalous development of the primitive tracheobronchial tree early in fetal life .
they are usually present in middle mediastinum .
rarely , they have been found in other locations .
we describe two patients with subcutaneous bronchogenic cysts located over manubrium sterni wit... |
found that serglycin is distinctively expressed in acute myeloid leukemia ( aml ) relative to lymphoblastic leukemia .
serglycin is also a selective marker distinguishing aml from philadelphia chromosome - negative chronic myeloproliferative disorders . in multiple myeloma cells ,
serglycin is a secreted protein de... | serglycin belongs to a family of small proteoglycans with ser - gly dipeptide repeats , and it is modified with different types of glycosaminoglycan side chains .
intracellular serglycin affects the retention and secretion of proteases , chemokines , or other cytokines by physically binding to these factors in secret... |
nonpolio afp case - patients showing signs of acute onset of focal weakness or paralysis characterized as flaccid ( reduced muscle tone ) and preceded by fever were considered for npev analysis .
august 2010 from children < 15 years of age who had afp symptoms were analyzed by using a modified world health organizati... | nonpolio acute flaccid paralysis is increasing in india . to determine viral causes
, we conducted cell culture and molecular analysis identification of nonpolio human enteroviruses associated with acute flaccid paralysis during march august 2010 in northern india .
the predominant nonpolio enterovirus found was e... |
proton pump inhibitors ( ppis ) have been used widely and achieved great benefits in managing acid - related upper gastrointestinal diseases , including gastroesophageal reflux disease ( gerd ) , peptic ulcer disease , helicobacter pylori infection , nonsteroidal anti - inflammatory drug ( nsaid)-associated gastric muc... | summarybackgrounduntil now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity .
the aim of this study is to compare the effect of lansoprazole ( 30 mg ) and pantoprazole ( 40 mg ) administered intravenously on gastric acidity.m... |
it results from invasion of pathogenic microorganisms ( bacteria , viruses , or fungi ) to the urinary tract system [ 1 , 2 ] .
incidence of disease in boys and girls has been reported 1% and 3 - 5% , respectively .
the disease manifests in three forms ; cystitis , pyelonephritis and asymptomatic bacteriuria [ 1 , ... | objectivethis study was performed to determine the relationship between urinary nitrite results and bacterial resistance to antimicrobial drugs in urinary tract infection of children.methodsin a cross - section study 119 children younger than 12 years with urinary tract infection were evaluated in qazvin children 's ho... |
despite the development of excellent diagnostic tools , there still remain patients with metastatic cancer in whom the site of the primary tumor can not be determined ; these patients are defined as having cancer of unknown primary ( cup ) [ 1 , 2 ] .
the prevalence of cup reportedly accounts for approximately 2 - 5%... | the optimal chemotherapeutic regimen for cancer of unknown primary ( cup ) remains uncertain .
we encountered 3 cases with cup who presented with thoracic lymph node metastasis . detailed physical examination and diagnostic tests , including laboratory investigations , bronchoscopy , upper and lower gastrointestinal ... |
on july 1 , 2004 , the 4 inmates from the california state prison in riverside county were hospitalized with signs and symptoms consistent with clinical botulism , including blurry vision , dysarthria , dysphagia , shortness of breath , and generalized muscle weakness .
none had a history of injection drug use and ha... | foodborne botulism occurred among inmates at 2 prisons in california in 2004 and 2005 . in the first outbreak ,
4 inmates were hospitalized , 2 of whom required intubation . in the second event ,
1 inmate required intubation .
pruno , an alcoholic drink made illicitly in prisons , was the novel vehicle for these ... |
the chapel hill consensus conference ( chcc ) on the nomenclature of systemic vasculitis defined pan or alternatively classic pan as a condition characterized by the necrotizing inflammation of medium - sized or small arteries , without glomerulonephritis or vasculitis in the arterioles , capillaries , or venules . in... | classic polyarteritis nodosa ( pan ) ) is a medium - sized vessel vasculitis that usually occurs in middle - aged men .
one of the dramatic manifestations of pan that requires surgical intervention is multiple small bowel perforations .
many studies have reported a high rate of mortality in pan due to acute abdomin... |
the human brain is a complex and efficient information system . learning changes this system as we adapt to information in the environment .
professional musicians comprise a special population for studying learning because they often begin intensive music training early in life and excel in various cognitive tasks ,... | musicians undergoing long - term musical training show improved emotional and cognitive function , which suggests the presence of neuroplasticity .
the structural and functional impacts of the human brain have been observed in musicians . in this study , we used data - driven functional connectivity analysis to map l... |
the muscle damage theory of delayed onset muscle soreness ( doms ) indicates that muscle pain
is caused by tiny lacerations of the muscle during strenuous exercise1,2,3 , and the muscular spasm theory states that muscle pain induced by
exercise causes muscular spasms , which cause local ischemia , inducing secretio... | [ purpose ] this study examined the effect of the distance between the two electrodes on delayed
onset muscle soreness during microcurrent therapy .
[ methods ] in this study 24 healthy
women who had nt exercised regularly for six months were selected and randomly divided
into two groups .
delayed onset muscl... |
sleep disorders have been described in the medical literature since the 19th century.1 obstructive sleep apnea ( osa ) is a treatable but markedly underdiagnosed condition of frequent breathing pauses during sleep .
osa is defined by recurrent episodes of apnea ( complete cessation of airflow ) or hypopnea associated... | objectivemany cases of obstructive sleep apnea ( osa ) involve collapse of the tongue base and soft palate during sleep , causing occlusion of the upper airway and leading to oxygen desaturation .
existing therapies can be effective , but they are plagued by patient adherence issues and the invasiveness of surgical a... |
ischemic stroke is the third leading cause of death worldwide with 5 million annual deaths .
every years approximately 795,000 people experience a stroke and someone dies of stroke in the united states every 3 - 4 minutes .
one of the prominent objectives of stroke research has been to investigate factors that coul... | objective .
the purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke ( ais ) patients . methods . a cohort of all adult patients presenting to the emergency department ( ed ) with an ais from march 2004 to december 2005 were selected .
the lipid pr... |
the dimensions of the edentulous residual ridge are not stable because of bone resorption and mucosal changes from muscle dynamics or tissue irritation . thus , complete
an ideal denture base would continuously adapt to the mucosa and thus should be flexible .
however , it also has to support the teeth during funct... | the ideal properties of a denture are adequate rigidity on polished surface to bear masticatory forces and at the same time , flexibility and softness on the tissue surface for proper and even distribution of masticatory forces .
the problem with conventional denture is rigidity of tissue surface ; leads to uneven di... |
the results are gripping hopkins and brett suggest that ' the neurocognitive impairments in ards [ acute respiratory distress syndrome ] survivors are long lasting and likely permanent ' .
i shall argue that it is difficult to pull apart the diverse factors that might prevent a patient 's return to clear thinking ... | a growing consensus seems to be emerging that neurocognitive outcomes are poor for patients who have been critically ill with acute respiratory distress syndrome and multiple organ failure .
however , intensive care unit delirium , post - traumatic stress disorder , and other outcomes must be considered as potentiall... |
techniques for directly assessing and quantifying rna by high - throughput sequencing , collectively known as rna - seq , have revealed unexpected complexity and diversity in human transcriptomes .
many previously unknown transcripts that are being detected are low - abundance long intergenic non - coding rnas ( lncr... | initial high - throughput rna sequencing ( rna - seq ) experiments have revealed a complex and dynamic transcriptome , but because it samples transcripts in proportion to their abundances , assessing the extent and nature of low - level transcription using this technique has been difficult . a new assay , rna capturese... |
a 75-year - old caucasian female , awaiting elective laparoscopic cholecystectomy , complained to her general practitioner of persistent cough , dyspnoea and low - grade fever that had lasted for more than one month .
she presented to the emergency department , where a chest radiograph showed areas of consolidation i... | a 75-year - old female underwent a high resolution computed tomography ( hrct ) scan for recurrent bronchitis and cough .
hrct images showed an anomalous supernumerary bronchus to the right upper lobe directly arising from the right side of distal trachea , corresponding to tracheal bronchus ( trb ) .
trb can cause... |
this study aims to report the expansion of a choroidal rupture site caused by blunt ocular trauma using scanning laser ophthalmoscope - optical coherence tomography .
the clinical course of a 15-year - old girl with a traumatic ocular injury after being hit in the eye by an elbow was evaluated . upon the first examin... | backgroundthis study aims to report the expansion of a choroidal rupture site caused by blunt ocular trauma using scanning laser ophthalmoscope - optical coherence tomography.case reportthe clinical course of a 15-year - old girl with a traumatic ocular injury after being hit in the eye by an elbow was evaluated . upon... |
studies on major depression , anxiety , schizophrenia , mania , autism , obesity , and drug addiction have implicated the involvement of serotonergic ( 5-ht ) abnormalities in these diseases .
serotonin acts via receptors which were classified into seven families ( 5-ht17 ) and at least 14 different subtypes ( barnes... | affinities of arylpiperazinylalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione for serotonin transporter and their acid base properties were evaluated .
the dissociation constant ( pka ) of compounds 122 were determinated by potentiometric titration and calculated using pkalc 3.1 module... |
prostate cancer is the third most common cancer in man and is the most commonly encountered malignancy in clinical practice . in the us , there were 27,360 deaths attributed to prostate cancer and 192,280 new cases diagnosed in 2009 .
about 1 in 6 males develop prostate cancer and 1 in 35 males die of this disease . ... | prostate cancer is the third most common cancer in man .
about 1 in 6 males developed prostate cancer and 1 in 35 males die of this disease .
prostate cancer behavior ranges from microscopic tumors to aggressive cancer with metastatic potential .
while metastasis to bone is relatively common , prostate cancer rar... |
bilateral salpingo - oophorectomy ( bso ) causes an abrupt decline in estrogen and acute increase in gonadotropin .
previous studies have shown an increase in the rate of coronary heart disease after bso.1,2 it has also been demonstrated that the risks of vertebral and hip fractures in women who have undergone bso in... | purposethe aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo - oophorectomy ( bso ) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.patients and methodsa total of 110 women were recruited for this study from the outpat... |
chronic obstructive pulmonary disease ( copd ) is the third leading cause of death in the us , with cigarette smoking being the most important environmental risk factor .
cigarette smoke inhalation alters the expression profile of oxidants and antioxidants in the lungs and produces an enormous oxidant burden .
anti... | oxidative stress provokes endoplasmic reticulum ( er ) stress - induced unfolded protein response ( upr ) in the lungs of chronic obstructive pulmonary ( copd ) subjects .
the antioxidant , glutathione peroxidase-1 ( gpx-1 ) , counters oxidative stress induced by cigarette smoke exposure . here
, we investigate whe... |
cherubism is a rare disease of autosomal dominant inheritance characterized by
painless , frequently symmetrical , enlargement of the jaws as a result of the replacement
of bone with fibrous tissue [ 1 - 16,20,29 ] .
the disease is also called familial fibrous dysplasia of the jaws , but recent genetic
investig... | abstractobjectivescherubism is a congenital childhood disease of autosomal dominant
inheritance .
this disease is characterized by painless bilateral
enlargement of the jaws , in which bone is replaced with fibrous tissue .
the condition has sui generis clinical , radiographic and
histological features , of w... |
congenital mirror movement disorder designates involuntary movements on one side of the body that occur as mirror of the intentional movements on the contralateral side .
a two - month old male infant was brought to the hospital due to bilateral identical movements of the hands . except for bilateral involuntary synk... | introduction : congenital mirror movement disorder designates involuntary movements on one side of the body that occur as mirror of the intentional movements on the contralateral side .
colpocephaly is described as persistence of fetal configuration of lateral ventricles.case presentation : a two - month old male inf... |
after cell fate determination and morphogenesis , neurons continue to differentiate by entering the phase of synapse formation .
most synaptic material required for this process is synthesized in the cell body of neurons and transported to synapses by microtubule ( mt)-based molecular motors ( fig .
mt - based mole... | synapse formation is a highly regulated process that requires the coordination of many cell biological events .
decades of research have identified a long list of molecular components involved in assembling a functioning synapse . yet how the various steps , from transporting synaptic components to adhering synaptic ... |
end - stage renal disease ( esrd ) has emerged as a major public health problem , with an alarming increase in incidences and a challenge for both developing and developed countries.1 globally , it is estimated that 1.9 million patients are currently receiving renal replacement therapy ( rrt ) , mainly dialysis.2 the n... | backgrounda number of reports suggest a link between depression and nonadherence to recommended management for end - stage renal disease ( esrd ) patients on maintenance dialysis . however , the relationship between nonadherence and other psychosocial factors have been inadequately examined.objectivesto examine the pre... |
we also describe the ultrasonography ( usg ) , computed tomography ( ct ) , and magnetic resonance imaging ( mri ) features with surgical and histopathological confirmation .
a 32-year - old male patient was referred to the radiology department for ct examination of the face with symptoms of swelling in the left side... | nasolabial cyst is a non - odontogenic , extraosseous , soft tissue cyst , commonly unilateral , located in the nasolabial fold .
bilateral nasolabial cysts are of rare occurrence .
this case report describes the multimodality imaging appearance of bilateral nasolabial cysts with a review of literature . |
there is a clear link between age and susceptibility to a wide range of diseases [ reviewed in ( niccoli and partridge 2012 ) ] and key among the age - related diseases that are rising in incidence is diabetes and metabolic syndrome .
ageing has specific consequences on mammalian physiology , but it also interacts wi... | ageing can be characterised by a general decline in cellular function , which affects whole - body homoeostasis with metabolic dysfunction a common hallmark of ageing .
the identification and characterisation of the genetic pathways involved are paramount to the understanding of how we age and the development of the... |
however , the use of this method has been limited because the superficial layer of the skin , the stratum corneum , is not sufficiently permeable to allow effective transfer of medication into the bloodstream . to enhance transportion of drugs through the skin , several approaches , including chemical enhancers ( johns... | prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery using a cymbal transducer array . in this study the physiologic response to ultrasound mediated transdermal insulin delivery is compared to that of subcutaneously administered insulin .
anesthetized rats ( 350550 g ) were di... |
tumors of the chest wall are uncommon and include benign and malignant diagnoses which can be further classified into those arising from bony structures and those of soft tissue origin .
the clinical findings and the radiological appearance of soft tissue chest wall tumors has been previously reported in the literatu... | abstractthe purpose of our study was to determine the clinical usefulness of percutaneous image - guided biopsy of chest wall masses .
a retrospective study of 28 patients who underwent image - guided biopsy of chest wall masses from 2005 to 2007 was performed . in 19 ( 68% ) patients ,
the mass was detected as par... |
during investigation of physical and genetic interactome of heat shock protein 90 ( hsp90 ) in saccharomyces cerevisiae several putative interacting proteins were identified , among them 2 protein pih1 and tah1 was named after their characteristic .
protein interacting with hsp90 was termed as pih1 ( also known as no... | recently discovered r2tp complex is an important multiprotein complex involved in multiple cellular process like snornp biogenesis , pikk signaling , rna polymerase ii assembly and apoptosis . within r2tp
complex , pih1 tightly interacts with rvb1/rvb2 and with tah1 to form r2tp macromolecular complex . r2tp
comple... |
it is estimated that today more than 347 million people suffer from diabetes mellitus ( dm ) globally .
diabetic retinopathy ( dr ) , one of the most common complications of dm , accounts for about 5% of world blindness ; this represents almost 5 million people in 2002 .
approximately 80% of all patients with dm du... | background . it is estimated that 347 million people suffer from diabetes mellitus ( dm ) , and almost 5 million are blind due to diabetic retinopathy ( dr ) .
the progression of dr can be slowed down with early diagnosis and treatment . therefore our aim was to develop a novel automated method for dr screening .
m... |
over millions of years , eukaryotic organisms evolved fine - tuned metabolic mechanisms for orchestrating the conversion of diverse carbon substrates into cellular energy .
these mechanisms include changes in gene transcription , allosteric regulation of metabolic enzymes by fluxing pools of intermediary metabolites ... | in recent years , protein lysine acetylation has emerged as a prominent and conserved regulatory posttranslational modification that is abundant on numerous enzymes involved in the processes of intermediary metabolism .
well - characterized mitochondrial processes of carbon utilization are enriched in acetyl - lysine... |
headache is the most common neurological symptom , but has a low healthcare and public profile , which is associated with under treatment and under recognition , despite being amongst the top ten causes of disability .
the arab world covers a large geographical area over the continents of africa and asia with an esti... | the epidemiology of headache in arab countries was systematically reviewed through medline identification of four papers reporting headache prevalence in the arab nations of qatar , saudi arabia ( 2 papers ) and oman .
the prevalence of headache varied from 8 to 12% in saudi arabia to 72.5% in qatar and 83.6% in oman... |
a 49-year - old male presented with an incidentally detected right renal mass on a health examination .
the patient had no symptoms or signs associated with the renal mass but presented with mild anemia ( hemoglobin , 11.6 g / dl ) and elevated alkaline phosphate ( 170 u / l ) .
an abdominal ct performed in another... | a 49-year - old man presented with an incidentally detected right renal mass on a health examination .
the abdominal computed tomography and magnetic resonance imaging showed a 3-cm right renal mass suspected of being a hypovascular tumor , such as papillary renal cell carcinoma , and an osteoblastic metastatic lesio... |
this study was approved by the ethical committee of the federal university of cear ,
brazil . all the children and
we included 40 h. pylori - positive children ( 18 females and 22 males )
from eight-18 years old with a mean age of 13.2 ( standard deviation = 3.2 ) years .
these
children had previously partici... | helicobacter pylori infection is one of the most common infections
worldwide and is associated with gastric diseases .
virulence factors such as vaca and
caga have been shown to increase the risk of these diseases .
studies have suggested a
causal role of caga epiya - c in gastric carcinogenesis and this fact... |
pulmonary tuberculosis is a common infection worldwide . in iran , particularly in the eastern part , fluctuations in tuberculosis prevalence are seen due to the migration of people from afghanistan . in smear - positive pulmonary tuberculosis ,
currently , the follow - ups are performed at the end of months 2 , 4 , ... | pulmonary tuberculosis is a common infection worldwide . in the eastern part of iran ,
fluctuations in tuberculosis prevalence are seen due to the migration of people from afghanistan .
the aim of this study was to evaluate the time of bacteriologic sputum conversion after treatment and affecting factors in those w... |
uric acid ( 2,6,8-trihydroxypurine , ua , figure 1 ) , the principal breakdown product of human purine metabolism , is mainly excreted by the kidney . normally , most of ua produced from the catabolism is reabsorbed into the blood circulation system and then passes through the kidney into urine . when ua in human urine... | based on the inhibitory effect of uric acid ( ua ) on luminol - co2 + chemiluminescence ( cl ) system , a sensitive method for the determination of ua at nanomolar level by flow injection ( fi ) cl was proposed .
the proposed method was successfully applied to real - time monitoring of ua excretion in human 24 h uri... |
studies on cancer - associated venous thromboembolism ( vte ) have encompassed a variety of perspectives , including incidence rates , related risk factors , prophylaxis , and treatment , for a range of tumors .
although few prospective studies have investigated the incidence of and risk factors for vte in asian pati... | purposepharmacologic thromboprophylaxis is routinely recommended for western cancer patients undergoing major surgery for prevention of venous thromboembolism ( vte ) .
however , it is uncertainwhetherroutine administration of pharmacologic thromboprophylaxis is necessary in all asian surgical cancer patients .
thi... |
once simply considered as the guardians of the central nervous system ( cns ) , microglia have more recently emerged as key players in regulating neuronal network excitability . indeed , physical and chemical alterations in the extracellular environment promote the synthesis and release of several microglia - derived... | microglia - neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability , such as epilepsy and neuropathic pain .
while a series of potential messengers have been postulated as substrates of the communication between microglia and neurons , including ... |
wolff parkinson white ( wpw ) syndrome is caused by pre - excitation of ventricle due to an abnormal accessory pathway , bundle of kent , between atria and ventricle bypassing atrio - ventricular node .
patients may present with symptoms ranging from mild chest discomfort , palpitation and hypotension to severe car... | we report a case of fibroid uterus with wolff parkinson white ( wpw ) syndrome in a 48-year - old female , posted for elective hysterectomy .
patient gave history of short recurrent episodes of palpitation and electrocardiograph confirmed the diagnosis of wpw syndrome .
the anaesthetic management of these patient... |
primary prevention efforts for cardiovascular disease ( cvd ) focus on the identification and modification of 3 established risk factors ( hypercholesterolemia , hypertension , and type 2 diabetes mellitus),1 which are associated with substantial longterm risk of cvd . for example , adults with one risk factor at midli... | backgroundprimary prevention of cardiovascular disease ( cvd ) focuses on treatment of risk factors , including hypercholesterolemia , hypertension , and type 2 diabetes mellitus .
we investigated whether a healthy diet in adolescence prevents development of clinical risk factors or incidence of cvd in adulthood.meth... |
thyroid nodules and cancer have long been considered to occur predominantly among women . on the other hand ,
male gender has been reported to be an important risk factor for the development of the subgroup of well - differentiated thyroid cancers , based on the occurrence of larger tumors , worse prognosis in follic... | to investigate the correlation between gender and the clinical presentation of papillary thyroid cancer and the long - term followup results , 435 patients who underwent total or near - total thyroidectomy were enrolled in this study . among these papillary thyroid cancer patients , 12.2% showed lymph node metastases a... |
it is well known that the shape and size of the inorganic nanoparticles have a great influence on their physical properties . in recent years
, the synthesis of nanoparticles with well - controlled morphology and size has received lots of interest for their potential applications in nanoscale plasmon photonics , drug... | a simple electrochemical deposition was developed to synthesize the cuprous oxide ( cu2o ) octahedra on aluminum foils .
the average edge length of the octahedra is about 300 nm .
the chemical composition of the octahedra was determined using energy dispersive x - ray spectroscopy and electron energy - loss spectr... |
the number of the patients with heart failure is increasing in both developed and developing countries , with approximately 1%2% of adults in developed countries experiencing heart failure ( 2 ) . in iran , the number of these patients is estimated to be about 3,500 out of 100,000 ( 3 ) .
meanwhile , about 50%55% of ... | introductioninner strength is a factor for mental health and well - being and , consequently , a dynamic component of holistic healing .
health - promoting behaviors are appropriate activities to improve health status and prevent the progression of the functional defect resulting from heart failure .
the present st... |
antimalarials are frequently used for presumptive treatment of fever especially in malaria endemic regions . in view of the increasing resistance to existing antimalarials
, india switched to artemisinin based therapy as first line antimalarial treatment in its national vector borne disease control programme . in 200... | objective . with large scale rollout of artemisinin based therapy in the national malaria control programme of india , a risk management plan is needed .
this depends on adverse drug reaction ( adr ) reporting by the healthcare professionals ( hcps ) . for the programme to be successful ,
an understanding of the mi... |
african trypanosomiasis is one of the neglected diseases currently ravaging several countries in the sub - saharan africa . the disease , which affects both humans and animals , is fatal if left untreated .
chemotherapy which forms the major means of controlling the disease scourge is currently faced with many challe... | current chemotherapies against trypanosomiasis are beset with diverse challenges , a situation which underscores the numerous research efforts aimed at finding newer and effective treatments .
arginine kinase of trypanosome has been validated as target for drug development against trypanosomiasis .
the present stud... |
after meningitis , brain abscesses represent the second most common intracranial complication of chronic otitis media ( com)14 ) , with an associated mortality rate ranging between 7% and 61% in most large series11,14 ) .
roughly 50% of brain abscesses in adults and 25% in children are believed to stem from otogenic ... | despite significant advances in the treatment of all forms of chronic otitis media ( com ) , complications still can and do occur , with intracranial complications representing the most life - threatening cases , often requiring immediate therapeutic intervention . herein , we present a rare case of rapidly progressing... |
during free time between clinical procedures , patients performed a spatial learning task on a bedside laptop computer .
our testing protocol is approved by the institutional review boards of thomas jefferson university and the university of california , los angeles . in this task
, patients learned the locations o... | grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system .
such cells , which have been identified in rats , bats , and monkeys , are believed to support a wide range of spatial behaviors . by recording neuronal activity from neurosurgical patients performing a virtu... |
mathematical models
for assessing drug permeability and predicting in vivo drug release from nanoparticle formulations would
be useful both in the design phase and during preclinical testing
where avoiding the extensive use of animals would be highly desirable .
such models would facilitate the design of formul... | drug release from liposomal formulations
is governed by a complex
interplay of kinetic ( i.e. , drug permeability ) and thermodynamic factors
( i.e. , drug partitioning to the bilayer surface ) .
release studies
under sink conditions that attempt to mimic physiological conditions
are insufficient to deciphe... |
upper gastrointestinal ( ugi ) cancers ( gastric and esophagus cancer ) constitute a major health problem worldwide ( 1 ) .
although a decreasing incidence of gastric cancer has been observed during the last decades , it remains the fourth most common cancer worldwide and the second leading cause of cancer - related ... | aimthe present study aimed to evaluate the prevalence of positive family history of these cancers in a large population - based sample of tehran province , capital of iran.backgroundupper gastrointestinal ( ugi ) cancers ( gastric and esophagus cancer ) constitute a major health problem worldwide .
a family history o... |
cissampelos sympodialis is a plant found in the northeast and southeast regions of brazil and its extract is popularly used in the treatment of both inflammatory and allergic diseases .
studies using the aqueous fraction of the ethanolic extract obtained from its leaves ( afl ) have confirmed its immunomodulatory e... | cissampelos sympodialis eichl is a plant from the northeast and southeast of brazil .
its root infusion is popularly used for treatment of inflammatory and allergic diseases .
we investigated whether warifteine , its main alkaloid , would have anti - inflammatory effect due to a blockage of neutrophil function . in... |
diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin or when the body can not effectively use the insulin it produces .
loss of -cell function caused by reduced insulin synthesis and secretion is one of the key events in the pathogenesis of type 2 diabetes .
normal cells can ... | background . oxidative stress induced by reactive oxygen and nitrogen species
is critically involved in the impairment of -cell function during the development of diabetes . methods .
hit - t15 cells were cultured in 5% co2 and then preincubated with gelam honey extracts ( 20 , 40 , 60 , and 80 g / ml ) as well as... |
nanostructured zno has been the source of great scientific interest , toward both the understanding and exploitation of its intrinsic properties and the performance in optoelectronic applications due to its direct wide band gap of 3.35 ev at 300 k and the high exciton binding energy of 60 mev .
consequently , fabrica... | zno nanowires with both good crystallinity and oxygen vacancies defects were synthesized by thermal oxidation of zn substrate pretreated in concentrated sulfuric acid under the air atmosphere , ar- and air - mixed gas stream .
the photoluminescence spectra reveal that only near - band - edge ( nbe ) emission peak was... |
an implantable cardioverter defibrillator ( icd ) is indicated for patients who were resuscitated from sudden cardiac death due to fatal ventricular tachyarrhythmias . in the past decade ,
several studies showed the superiority of an icd over antiarrthythmic drug therapy1)2 ) and nowadays , icd has proven to be effec... | a 50-year - old man , who underwent a procedure for an implantable cardioverter defibrillator ( icd ) , visited the outpatient department of our clinic after suffering multiple icd shocks .
the icd interrogation revealed recurrent shock due to a high frequency of noise that is sensed by the device as ventricular fibr... |
duplicate or redundant publication describes a practice where 2 or more articles that share substantially similar information are published by the same author(s ) , without clear , visible reference to the previous publication .
it is time and resource wasting for the readers , peer reviewers , and editors and unnece... | objective .
the aim of this study was to ( a ) determine the rate of redundant publication in the pediatrics literature and ( b ) to characterize these articles .
methods . index articles in jama pediatrics , pediatrics , and the journal of pediatrics from 2010 were identified using pubmed .
possible redundant ma... |
kawasaki disease ( kd ) is a self - limited , systemic vasculitis of unknown etiology that affects the small and medium - sized blood vessels of the body .
occur in children less than 5 years of age , and the incidence is highly varied , ranging from 4 to 216 per 100,000 children less than 5 years of age worldwide . ... | sensorineural hearing loss ( snhl ) that is seldom cited as a kawasaki disease ( kd ) complication is known as an additional , potentially severe , and frequently irreversible sequel .
furthermore the vestibular functions of kd have been underestimated and it could be an important complication combined with snhl in k... |
dementia is a multifaceted syndrome that lays claim to a growing burden of global disease : the most recent estimates suggest that there are 44 million affected individuals worldwide and a further 7.7 million new cases annually ( 1,2 ) . underpinned by a shifting demographic and associated epidemiological profile world... | objectivetype 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men .
diabetes is also a risk factor for dementia , but whether the association is similar in women and men remains unknown .
we performed a meta - analysis of unpublished data to estimate the sex - specific relationsh... |
we have a limited capacity to process all of the visual information that enters our visual field at any point in time .
for this reason , selective attention to salient stimuli is necessary as it helps us decide where to move our eyes next . in this regard ,
our attentional system enhances the processing of relevan... | inhibition of return ( ior ) refers to a bias against returning the attention to a previously attended location . as a foraging facilitator
it is thought to facilitate systematic visual search . with respect to neutral stimuli ,
this is generally thought to be adaptive , but when threatening stimuli appear in our e... |
we report a case of a 64 year old caucasian male with a history of kidney transplant , after an aortic valve repair who was recovering in the cardiac critical care unit .
a consult was placed to the transplant surgery team on post - operative day four after aortic valve exploration and repair of a paravalvular prosth... | highlightsfemoral herniation of transplanted ureter is a rare occurrence and has not been documented in the literature to date.such patients may present with transplant kidney failure due to obstructive uropathy.diagnosis includes physical exam , transplant kidney ultrasound or ct of abdomen and pelvis.treatment should... |
feline leukemia virus ( felv ) is a highly contagious virus that is readily spread among cats in casual close contact , which can include sharing food and water , as well as mutual grooming .
approximately one - third of cats exposed to felv develop progressive viremia and most die of felv - related diseases within 3... | objectivesfeline leukemia virus ( felv ) is a potentially life - threatening oncogenic retrovirus .
the p27 viral core protein is produced by the virus in infected feline cells , is found in the cytoplasm in several blood cells and can be free in the serum and plasma .
elisa or particle - based immunoassay are comm... |
during last 10 years , several high throughput and even high output structure determination pipelines ( mostly using x - ray diffraction methods ) were developed by a number of multi - institutional consortia .
they all share the same goal : rapid progress from the cloning of a protein gene to the determination an... | new protocols and instrumentation significantly boost the outcome of structural biology , which has resulted in significant growth in the number of deposited protein data bank structures .
however , even an enormous increase of the productivity of a single step of the structure determination process may not significa... |
haemosuccus pancreaticus is a rare and potentially life threatening clinical entity , and is described as bleeding from the ampulla of vater via the pancreatic duct .
the syndrome is classically attributed to erosion of the splenic artery aneurysm in to the pancreatic duct or bleeding in to a pseudopancreatic cyst as... | haemosuccus pancreaticus is an unusual cause of severe upper gastrointestinal bleeding and results from rupture of splenic artery aneurysm into the pancreatic duct .
more commonly , it is a pseudoaneurysm of the splenic artery which develops as sequelae of pancreatitis .
however , true aneurysm of the splenic arte... |
viruses exploit the molecular machinery of the infected host to support their own life cycle and target host defense mechanisms to escape host resistance .
this is achieved by establishing a virus - specific protein interaction network that perturbs cell processes , such as dna replication , gene expression , growth ... | viral infections often cause diseases by perturbing several cellular processes in the infected host .
viral proteins target host proteins and either form new complexes or modulate the formation of functional host complexes . describing and understanding the perturbation of the host interactome following viral infecti... |
cz and croscarmellose sodium ( ccs ) were gift samples from torrent pharma , ahmedabad , india and wockhardt research centre , aurangabad , india respectively .
directly compressible mannitol ( pearlitol sd 200 ) , sodium stearyl fumarate ( ssf ) were generous gifts from strides arco labs , bangalore , india , glenma... | fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance .
a 32 full factorial design was applied to investigate the combined effect of two formulation variables : amount of croscarmellose sodium and camphor .
croscarmellose sodium ( 2 - 8% w / w ) was used... |
nontuberculous mycobacterial ( ntm ) organisms are widely distributed in the environment and the frequency of ntm pulmonary disease has been reported to be increasing ( 1 , 2 ) .
ntm species are divided into slow - growing and rapid - growing species by the runyon classification ( 2 ) .
representatives of the slow ... | we aimed to compare the ct findings of nontuberculous mycobacterial pulmonary diseases caused by mycobacterium avium - intracellulare complex ( mac ) and mycobacterium abscessus .
two chest radiologists analyzed retrospectively the thin - section ct findings of 51 patients with mac and 36 with m. abscessus infection ... |
pepe ) in the containers in the spring of 2002 . a disease suspected as mucor soft rot occurred on cherry tomato ( lycopersicon esculentum ) in agricultural products wholesale market in jinju .
the fungus attacked only dropping fruits in the field or cracks of matured fruits of cherry tomato ( fig .
the infected pa... | a soft rot of fruits caused by mucor racemosus occurred on cherry tomato collected in agricultural products wholesale market in jinju , korea .
the disease infection usually occurred wounded areas after cracking of fruits . at first , the lesions started with water soaked and rapidly softened and diseased lesion grad... |
patients with relapsed / refractory ( r / r ) b - precursor acute lymphoblastic leukemia ( all ) and patients whose minimal residual disease ( mrd ) persists during front - line treatment or who become mrd positive following treatment have a poor leukemia - free survival ( lfs ) . despite improvements in upfront treatm... | patients with relapsed / refractory ( r / r ) b - precursor acute lymphoblastic leukemia ( all ) and patients whose minimal residual disease persists during treatment have a poor leukemia - free survival . despite improvements in front - line therapy ,
the outcome in these patients remains poor , especially after rel... |
several types of monochromators have been developed for electron microscopy in this decade and are now available as a tool for material characterization .
they can reduce the energy spread of incident electrons to milli - electron - volt level .
monochromators can improve a diverse range of electron microscopy tech... | a few practical aspects of monochromators recently developed for transmission electron microscopy are briefly reviewed .
the basic structures and properties of four monochromators , a single wien filter monochromator , a double wien filter monochromator , an omega - shaped electrostatic monochromator and an alpha - s... |
( nephropathy , neuropathy , and retinopathy ) and macrovascular diseases ( atherosclerosis of coronary , cerebral , and peripheral arteries ) are prevalent in diabetic patients .
diabetes is associated with polyvascular , accelerated , and diffuse atherosclerotic diseases . in advanced stages , the chances of athero... | diabetes is associated with hyperglycemia and increased thrombin production . however
, it is unknown whether a combination of high glucose and thrombin can modulate the expression of napdh oxidase ( nox ) subtypes in human aortic endothelial cells ( haecs ) .
moreover , we investigated the role of a diabetes - ass... |
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