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depending on the primary site there may be a different prognosis and biological characteristics ; in fact , an aggressive clinical course and a high rate of systemic relapse after curative resection in the abdominal primary site are observed .
when surgical margins are close , especially in high - grade sarcomas , pr... | sarcomas arising from the chest wall account for less than 20% of all soft tissue sarcomas , and at this site , primitive tumors are the most frequent to occur .
leiomyosarcoma is a malignant smooth muscle tumor and the best outcomes are achieved with wide surgical excision . although advancements have been made in t... |
in eukaryotes , dna is packaged into a group of histone proteins to form nucleosome , the basic structural unit of chromatin .
dimers of four distinct histone proteins ( h2a , h2b , h3 , and h4 ) constitutes the histone octamer that is a structural scaffold for nucleosome . because dna is tightly packaged in nucleoso... | polycomb group ( pcg ) proteins are conserved chromatin regulators involved in the control of key developmental programs in eukaryotes .
they collectively provide the transcriptional memory unique to each cell identity by maintaining transcriptional states of developmental genes .
pcg proteins form multi - protein ... |
cyclophosphamide , doxorubicin , vincristine , and prednisolone ( chop ) therapy is an effective systemic chemotherapy for non - hodgkin 's lymphoma , and chop - based regimens have been widely used .
however , most of these drugs can not cross the blood - brain barrier , and thus they fail to attain effective concen... | cerebral involvement frequently occurs in association with progression or relapse of malignant lymphoma .
chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisolone , the standard chemotherapy for malignant lymphoma , is an ineffective treatment for cerebral involvement because these drugs can ... |
atherosclerosis is the major cause of cardiovascular morbidity and mortality , with underlying pathological processes that may begin during childhood [ 1 , 2 ] .
although the exact causes of atherosclerosis are not clear , it is thought to involve lipoprotein influx into the wall , across the endothelium , and chroni... | this paper presents an automatic detection method for thin boundaries of silver - stained endothelial cells ( ecs ) imaged using light microscopy of endothelium mono - layers from rabbit aortas . to achieve this ,
a segmentation technique was developed , which relies on a rich feature space to describe the spatial ne... |
in the previous issue of critical care , wittbrodt and colleagues report the results of their long - term follow - up of human subjects from a randomized trial comparing hydroxyethyl starch and ringer 's acetate solution . at first glance
, the authors ' observations appear to be pedestrian and could be misperceive... | long - term follow - up of randomized prospective trials of treatments in the intensive care unit may allow us to attain some understanding of the causes of post - intensive care syndrome .
this in turn may allow us to produce better long - term outcomes among survivors of critical illness . |
however , the egna - neumarkt glaucoma study stated that the burden of pacg in europe has been underestimated previously .
the prevalence in this study was 0.6% , which accounts for about a quarter of all primary glaucoma cases .
the most frequent type was chronic angle closure , which is more insidious and hence m... | objectives . to determine if hyperopia is a risk factor for primary angle - closure glaucoma ( pacg ) in the dutch population and to identify other biometrical parameters as risk factors for pacg including axial length ( al ) , anterior chamber depth ( acd ) , and k values . methods .
the study population consisted o... |
type 2 diabetes mellitus ( t2 dm ) is a chronic disease arising from both environmental and genetic factors .
t2 dm is characterized by disrupted secretory activity in pancreatic -cells , resistance to insulin action in peripheral tissues , or both together .
new treatment options for t2 dm are needed because curre... | background . our aim was to define the conditions that affect therapeutic success when dipeptidyl peptidase-4 ( dpp-4 ) inhibitor is added to metformin monotherapy .
materials and methods .
we reviewed the medical records of 56 patients who had received dpp-4 inhibitor as an add - on to metformin monotherapy and ev... |
this network enabled assessment of serum samples from patients during the early clinical phase of infection .
of these samples , 377 were positive for igg against puuv , of which 330 were positive for igm against puuv by an in - house elisa ( 11 ) and immunoblot assay ( recomline bunyavirus ; mikrogen , neuried , ger... | to investigate 2,017 cases of hantavirus disease in germany , we compared 38 new patient - derived puumala virus rna sequences identified in 2010 with bank vole derived small segment rna sequences .
the epidemic process was driven by outbreaks of 6 puumala virus clades comprising strains of human and vole origin .
... |
imaging has an important role to play in the management of breast diseases , which often present as breast mass , breast pain and the likes .
breast imaging has only come of age in the twenteith century , beginning with the introduction of mammography , which stemmed from the discoveries of x - rays and radiation in ... | background : breast imaging plays a vital role in the multidisciplinary approach to management of breast disease .
a baseline data is apt and necessary for collaborative studies.materials and methods : this is a prospective descriptive study carried out between january 2009 and december 2013 at our institution .
pa... |
the incidence of cutaneous melanoma ( cm ) continues to increase in the caucasian population in the united states . in 2014 , women only accounted for 42% of the 76,100 new melanoma cases and only 33% of the 9,710 deaths associated with cm in the united states .
indeed , gender disparity in melanoma outcome is so con... | backgroundgender disparity in melanoma outcome is consistently observed , suggesting that gender is as an important prognostic factor .
however , the source of this gender disparity in melanoma remains unclear.objectivethis article reviews advances in our understanding of gender differences in melanoma and how such d... |
parathyroid dysfunction is well known in long duration lithium treatment , though it is less frequent when compared to hypothyroidism .
we are reporting a patient who developed hypercalcemia while on treatment with lithium , requiring surgical treatment .
a 28-year - old lady reported to the endocrinology departmen... | lithium salts are widely used in psychiatric practice and are known to induce thyroid dysfunction .
lithium - induced parathyroid dysfunction is rare .
we are reporting a case of hyperparathyroidism in a 28-year - old female patient who was on lithium carbonate for 2 years , when she developed osteopenia and girdle... |
, actin is a key player in the development of neurons and maintenance of neuronal physiology . in developing neurons
, actin provides the structural network for morphogenesis . in adult neurons , actin participates in the formation and dynamics of pre- and postsynaptic structural integrity .
therefore , it is not a... | shank proteins ( shank1 , shank2 , and shank3 ) act as scaffolding molecules in the postsynaptic density of many excitatory neurons .
mutations in shank genes , in particular shank2 and shank3 , lead to autism spectrum disorders ( asd ) in both human and mouse models .
shank3 proteins are made of several domains t... |
gamma - secretase is a key protease activity involved in the production of alzheimer 's disease a amyloid peptides and in regulated intramembrane processing of a subset of membrane receptors , including notch ( reviewed in ) .
a is proteolytically derived from the type i integral amyloid precursor protein ( app ) b... | gamma - secretase is involved in the production of a amyloid peptides .
it cleaves the transmembrane domain of the amyloid precursor protein ( app ) at alternative sites to produce a and the app intracellular domain ( aicd ) .
metal ions play an important role in a aggregation and metabolism , thus metal chelators ... |
epilepsy is the most common serious chronic neurological brain disorder afflicting humankind , with no racial , socioeconomic , national , or geographic predilections ; it affects more than 50 million people worldwide .
the tendency of epilepsy to onset in children renders its socioeconomic impact disproportionate ; ... | previously , we have identified -alanine as a potential endogenous anticonvulsant molecule .
-alanine occurs within the human central nervous system and has been identified as both an inhibitory neuromodulator and neurotransmitter that is bioavailable to brain after oral administration . during preliminary compoundin... |
cells migrate by coordinating cytoskeletal - mediated extensions and contractions concomitantly with making and breaking contacts to an underlying substratum . to orchestrate directional movements , cells must activate a specific site(s ) at the membrane periphery in response to a polarized external cue ( fig . 1 ;
c... | for many years after the discovery of actin filaments and microtubules , it was widely assumed that their polymerization , organization , and functions were largely distinct .
however , in recent years it has become increasingly apparent that coordinated interactions between microtubules and filamentous actin are inv... |
hyperphosphatemia is a risk factor for secondary hyperparathyroidism , a serious complication that increases the risk of cardiovascular diseases in hemodialysis patients .
lanthanum carbonate ( lac ) , a phosphate binder that does not contain calcium , has been reported to decrease serum phosphorus levels .
it has ... | lanthanum carbonate ( lac ) is a non - calcium - based phosphate binder used to treat hyperphosphatemia in patients with chronic kidney disease .
oral administration of lac is difficult in patients undergoing tube feeding or those who are of advanced age because it is essential to chew the lac tablet sufficiently bef... |
despite the fact that the outcome of patients with systemic lupus erythematosus ( sle ) has improved considerably over the last decades , neuropshychiatric involvement remains a main cause of morbi - mortality
1 ,
2 , being responsible for up to 19% of deaths in sle
3 ,
4 .
the real prevalence of neuropsychia... | neuropsychiatric lupus is a major diagnostic challenge , and a main cause of morbidity and mortality in patients with systemic lupus erythematosus ( sle ) . magnetic resonance imaging ( mri )
is , by far , the main tool for assessing the brain in this disease .
conventional and advanced mri techniques are used to h... |
transurethral resection of the prostate ( turp ) is considered the standard treatment for men with benign prostatic hyperplasia ( bph ) ( 1 ) . however , this procedure is associated with significant morbidity . in order to minimize the perioperative morbidity of turp procedures , various minimally invasive alternative... | the aim of this study was to develop a new simple method for measuring the vaporized volume and to evaluate the outcome of high - power potassium - titanyl - phosphate ( ktp ) photoselective laser vaporization .
a total of 65 patients , with a mean age of 67.7 yr ( range 53 to 85 ) , were included in the primary anal... |
endoscopic treatment of stone disease in children has developed dramatically during the last 2 decades . since
the first pediatric ureteroscopic procedure in 1988 , ureterorenoscopy ( urs ) has become a more attractive option for treating children due to significant improvements in the miniaturization and durability ... | backgroundwe aimed to assess the effectiveness of semi - rigid ureteroscopy and holmium laser lithotripsy in the treatment of impacted ureteral stones in children.material/methodswe evaluated a total of 32 children under the age of 18 years treated with ureteroscopic holmium laser lithotripsy for impacted ureteral ston... |
for decades , endodontically treated teeth with significant coronal tissue loss were restored with cast metal post and core . despite the high retention rate and thin layer of cement , metal posts have been associated with irreparable root fractures .
this is primarily due to the modulus of elasticity of metal being ... | purpose : evaluate the bond strength of different translucent fiber posts in the cervical , middle , and apical root thirds cemented with self - adhesive resin cement.materials and methods : sixty single - rooted teeth were randomly divided into five groups according to the fiber post used : reforpost ( opaque [ contro... |
risks to human health arise from the environment in diverse ways and from many sources .
although there are many social forces to be considered when efforts are made to protect human health , it would seem that public health resources should be devoted to reducing risks arising from the environment in at least rough ... | |
low - molecular - weight heparins ( lmwhs ) have become the predominant choice as first line agents for both the prophylaxis of and treatment for deep venous thrombosis ( dvt ) .
these agents are popular for inpatient and home administration because of the decreased need for laboratory monitoring , resulting in lower... | introductionbleeding related to low - molecular - weight heparins ( lmwhs ) is typically described as an excess of minor bleeding ; however , several reports of spontaneous major bleeding have been noted.presentation of casea 58-year - old female presented to the hospital with bilateral spontaneous lower extremity hema... |
recent reports have highlighted white adipose tissue ( wat ) as one of the primary contributors to the chronic low - grade inflammation commonly observed in obesity and related complications ( e.g. , type 2 diabetes , metabolic syndrome ) .
as wat expands , it has been hypothesized that microhypoxia results in adipoc... | we aimed to determine the effects of 6 wks of exercise on inflammatory markers in mice concomitantly fed either high - fat ( hf ) or normal chow ( nc ) diets in young mice .
c57bl/6 mice were randomized into ( n = 10/group ) an nc / sedentary ( nc / sed ) , nc / exercise ( nc / ex ) , hf / sed , and hf / ex groups . ... |
at the first of july 2006 , the rohs directive of the european union ( directive on the restriction of the use of certain hazardous substances in electrical and electronic equipment 2002/95/ec ) has come into force . due to this directive
the use of lead is prohibited in electronic products , however , with a num... | the partial and integral enthalpy of mixing of molten ternary co sb
sn alloys was determined performing high temperature drop calorimetry in a large compositional range at 1273 k. measurements have been done along five sections , xsb / xsn 1:1 , xsb / xsn 1:3 , xsb / xsn 3:1 , xco / xsn 1:4 , and xco / ... |
the approach we adopted in our first experiments was to create a cavity in the cerebral cortex which could serve as a culturing chamber where the exposed vessel - rich surface of the underlying choroidal fissue could serve as a source of rapid vascularization .
small pieces of tissue dissected from the fetal brain ... | the efforts to develop a dopamine cell replacement therapy for parkinson s disease have spanned over more than three decades . based on almost 10 years of transplantation studies in animal models ,
the first patients receiving grafts of fetal - derived dopamine neuroblasts were operated in lund in 1987 . over the fol... |
a 60-year - old woman is presented who required resection of both pulmonary and adrenal metastases from cervical adenocarcinoma .
the patient was diagnosed with stage ia adenocarcinoma of the cervix which was treated surgically .
five years later she was diagnosed with recurrent , metastatic cervical adenocarcinoma... | we present a 60-year old woman with recurrent cervical adenocarcinoma who presented with metastasis to both lungs and to her right adrenal gland .
a thoracotomy was performed for resection of her pulmonary metastasis and then the right adrenal gland was excised through a trans - diaphragmatic approach . the adrenal g... |
mexican population is estimated to be over 120 million of which 78% lives in urban areas [ 1 , 2 ] .
this implies a significant burden to provide medical care where gdp is nearly $ 1,300 billion usd and average income per capita is fairly below $ 10 thousand usd . yet
nearly a fourth of its citizens is deprived of ... | objective .
assessment of the frequency of complications observed with various forceps and operative vaginal delivery ( ovd ) techniques performed at the abc medical center ( mexico city ) to evaluate their safety , bearing in mind the importance of decreasing our country 's high cesarean section incidence .
method... |
a 38-year - old woman planned to undergo open heart surgery to surgically correct a known severe mr .
she had a history of undergoing percutaneous balloon valvuloplasty due to rheumatic mitral stenosis ( ms ) during a previous pregnancy 10 years before . at the preoperative evaluation employing 2d tte ,
a tearing o... | a precise pre - procedural evaluation of mitral valve ( mv ) pathology is essential for planning the surgical strategy for severe mitral regurgitation ( mr ) and preparing for the intraoperative procedure . in the present case ,
a 38-year - old woman was scheduled to undergo mv replacement due to severe mr .
she ha... |
phosphorus is necessary for several , various biological roles in the signal transduction of cells and energy exchange of human body . about 80%90% of phosphorus
mineral balance is regulated by a complex interaction between gastrointestinal absorption , renal excretion and translocation between parts of the human bod... | purposehigh serum inorganic phosphorus level is related with atherosclerosis and an elevated risk of cardiovascular disease . at the same time , the association of phosphorus with erectile dysfunction ( ed ) is not well reported .
we studied the effect of serum phosphorus on ed and the relationship with other clinica... |
cancer is the third leading cause of death worldwide , and lung cancer is the second most commonly occurring non - cutaneous cancer with the highest mortality rate among all cancers .
there are 1.38 million new cases of lung cancer every year , along with 1.23 million deaths due to lung cancer.1 based on the histolog... | lung cancer is the second most commonly occurring non - cutaneous cancer in the united states with the highest mortality rate among both men and women . in this study
, we utilized three lung cancer microarray datasets generated by previous researchers to identify differentially expressed genes , altered signaling pa... |
restoration of missing , decayed or mutilated dentition has been one of the foremost responsibilities of dentists the world over .
materials selected for the restoration of teeth should fulfill the basic criteria of strength , biocompatibility and esthetics . in the past , metals were employed widely due to their uns... | statement of problem : surface of porcelain restoration is a matter of clinical concern because of its abrasive action on the opposing enamel.purpose:this study comparatively evaluated wear of enamel when opposed by three different surface finishes of ceramic.materials and methods : a total of 60 metal - ceramic discs ... |
we screened stool specimens for sav by using rt - pcr and described the genetic diversity of virus - positive specimens .
a total of 95 stool specimens were collected from children < 18 years of age treated for gastrointestinal illness at the sydney children 's hospital .
these specimens were negative for common fo... | sapovirus was detected in 7 of 95 stool specimens from children with gastroenteritis of unknown etiology in sydney , australia , from august 2001 to august 2002 and from february 2004 to august 2004 , by using reverse transcription polymerase chain reaction .
sequence analysis of the n - terminal capsid region showe... |
psoriasis , a common and enigmatic recurrent cutaneous disease , has
for long been considered a hyperproliferation with extremely increased rate of epidermal turnover , and an activated
mononuclear infiltrate in the underlyingdermis .
recent progress in the understanding of
psoriasis has attributed its pathogen... | recent progress in the understanding of psoriasis
has shown that the regulation of local and systemic cytokines
plays an important role in its pathogenesis .
the most
often used psoriasis score is the psoriasis area and severity
index ( pasi ) .
a simple laboratory test from a blood sample would
be an att... |
esophageal varices are the major complication of portal hypertension . it is detected in about 50% of cirrhosis patients , and approximately 515% of cirrhosis patients show newly formed varices or worsening of varices each year [ 15 ] .
it is a hemodynamic abnormality characterized by sudden bleeding episode ; about ... | esophageal varices are the major complication of portal hypertension . it is detected in about 50% of cirrhosis patients , and approximately 515% of cirrhosis patients show newly formed varices or worsening of varices each year .
the major therapeutic strategy of esophageal varices consists of primary prevention , tr... |
hand disability limits a patient 's activities of daily life , leading to reductions in self - sufficiency and deterioration of quality of life . this condition can be caused by injuries , surgery and diseases .
recovering hand function requires pharmacological treatment together with a rehabilitation protocol includ... | current clinical practice suggests that recovering the hand functionality lost or reduced by injuries , interventions and chronic diseases requires , beyond pharmacological treatments , a kinesiotherapic intervention .
this form of rehabilitation consists of physical exercises adapted to the specific pathology .
it... |
the main structures that are known to process pain are the primary and secondary somatosensory , insula , anterior cingulated , and prefrontal cortices , as well as the thalamus ( 1 ) .
additional structures that play a smaller role are the basal ganglia , cerebellum , amygdala , hippocampus , and areas within the pa... | the mechanism of chronic pain is very complicated .
memory , pain , and opioid dependence appear to share common mechanism , including synaptic plasticity , and anatomical structures .
a 48-yr - old woman with severe pain caused by bone metastasis of breast cancer received epidural block .
after local anesthetics... |
it is a rather dynamic process of wound healing in response to a variety of persistent liver injury caused by factors such as ethanol intake , chronic hepatitis b virus ( hbv ) and hepatitis c virus ( hcv ) infection , drugs , toxins , cholestasis , and metabolic disorders .
liver fibrogenesis is a common widespread ... | introductioninterleukin ( il)-22 , originally referred to as il - tif for il-10-related t cell - derived inducible factor , is a member of the il-10-like cytokine family . il-22
is highly expressed by th17 cells and is tightly linked to chronic inflammation , including inflammatory bowel disease and local intestinal ... |
multidimensional
infrared spectroscopy probes nuclear motions in
condensed phase and biomolecular systems through the dynamics associated
with vibrational couplings .
maximal interpretation of multidimensional vibrational
spectra in terms of molecular structure and dynamical fluctuations
relies on simulatin... | the optimized mean - trajectory ( omt )
approximation is a semiclassical
method for computing vibrational response functions from action - quantized
classical trajectories connected by discrete transitions representing
radiation matter interactions . here
we apply this method to
an anharmonic chromophore c... |
fluticasone propionatemicroparticles were prepared by the spray - drying method using chitosan , mannitol along with l - leucine .
the particle sizes of the microparticles were increased with the increase in the chitosan concentration . as low
inlet temperatures of air - drying and feed flow rate are important para... | the objective of this study was to examine extensively the influences of formulation and process variables on the microparticles .
the microparticles were generated by the spray - drying technique using polymer chitosan , mannitol along with l - leucine .
the effects of various experimental parameters such as polym... |
mucocele is a common salivary gland disorder which is defined as a mucus filling cyst that usually appears in the oral cavity , paranasal sinuses , or lacrimal sac .
the term mucocele is derived from a latin word , mucus and cocele meaning cavity .
clinically , mucoceles are of two types ( a ) extravasation and ( b... | a mucocele is a common salivary gland disorder that most commonly affects young adults .
a 35-year - old female patient reported to the department of oral and maxillofacial surgery , with the chief complaint of swelling on the left side of floor of mouth .
the aim of this case report is to present the management of... |
the rise in the prevalence of obesity over the past decade has become an increasingly relevant issue because this medical condition is an important risk factor for type 2 diabetes mellitus ( t2 dm ) and cardiovascular disease ( cvd ) , which may lead to a higher incidence of all - cause mortality .
approximately 30% ... | metabolically healthy obesity ( mho ) is a new concept in which an individual may exhibit an obese phenotype in the absence of any metabolic abnormalities .
there are a number of definitions of mho that utilize a variety of components .
the findings of clinical and basic studies indicate that subjects with mho do n... |
drilling into mechanisms governing the control of hemoglobin synthesis led to the discovery in the 1980s of a new class of transcription factors containing a highly conserved cys4 dual zinc finger dna - binding module .
these proteins were deemed gata factors based on the nucleotide composition of their cognate dna -... | numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies .
the master regulator of hematopoietic stem / progenitor cells gata-2 was cloned almost 20 years ago , and elegant genetic analyses demonstrated its essential function to promot... |
we can model circulation systems in order to find the parameters of pressure , flow and blood volume . among the variables that are involved in the value of these parameters
, we can point to the dimensions and elasticity of vessels , fluid density at standard conditions and viscosity of vessel . for better analysis ... | background : with increasing age , some changes appeared in specifications of vessels which including dimensions and elasticity in theirs .
the changes in parameters such as resistance , inertance and compliance vessels appear and eventually changes in the environmental pulse releases are in circulation .
these cha... |
hypertension is considered the leading risk factor for cardiovascular disease ( cvd ) , with myocardial infarction and stroke accounting for most cases.1 because of its high prevalence , hypertension is responsible for the majority of the cases of cvd.2 however , data from longitudinal cohort studies are subject to con... | backgroundhypertension alone is a poor predictor of the individual risk of cardiovascular disease .
hereditary factors of which hypertension is merely a marker may explain why some hypertensive individuals appear more susceptible to cardiovascular disease , and why some ethnicities have more often seemingly hypertens... |
this article is a descriptive analytic research carried out as a case - control study during years 2007 and 2008 in isfahan university of medical sciences , school of medicine .
the study included 100 children and adolescents from 5 to 18 years old with type 1 diabetes mellitus referred to the isfahan diabetes resear... | background : diabetes mellitus is one of the most important epidemics of our era . complications of this disease are diverse and include retinopathy , nephropathy and neuropathy .
this study has been designed to evaluate hearing loss patterns in young children suffering from iddm and define risk factors for this comp... |
a 12-year - old boy known to have idiopathic he s presented to our ed with a complaint of cough , shortness of breath ( sob ) , and severe chest tightness for the previous 1 h. he had been diagnosed with refractory he s 4 years back , with a course complicated by multiple organ involvement .
previous medications inc... | chest pain is usually a benign presentation in children who present to emergency departments ( ed ) or primary care centers . unlike adults ,
where chest pain is commonly due to cardiac causes , in children the cause is more likely secondary to non - cardiac causes . here
we present a case of a child known to have ... |
studies have shown that in the 20 century , 80% of scientific productions were related to science and technology ( 2 ) .
scientific works requires information , and also the essential part of information is derived from previous works ( 3 ) .
the world of education , technology , and research is also faced with inc... | background : this study defines necessary data elements required for the research information system in the domain of health , and its level of accountability to national health research indicators from the experts perspective is being explored.methods:this qualitative study was conducted based on comparative approach ... |
williams syndrome ( omim # 194050 ) is a rare , well - documented , multisystem genetic condition affecting approximately 1/7,500 individuals .
there are no marked regional differences in the prevalence of this disease.1 ) the syndrome is caused by the hemizygous deletion of approximately 28 genes , including eln on ... | williams syndrome ( omim # 194050 ) is a rare , well - recognized , multisystemic genetic condition affecting approximately 1/7,500 individuals .
there are no marked regional differences in the incidence of williams syndrome .
the syndrome is caused by a hemizygous deletion of approximately 28 genes , including eln... |
in a genome - wide association study of breast cancer conducted among chinese women , we identified a new susceptibility locus for breast cancer , the single nucleotide polymorphism ( snp ) rs2046210 .
snp rs2046210 is located on chromosome 6q25.1 , 29 kb upstream of the first untranslated exon and 180 kb upstream of... | a recent genome - wide association study identified a new susceptibility locus for breast cancer , rs2046210 , which is a single nucleotide polymorphism ( snp ) located upstream of the estrogen receptor ( esr1 ) gene on chromosome 6q25.1 . given that endometrial cancer shares many risk factors with breast cancer and b... |
the term proteomics describes the study and characterization of complete set of proteins present in a cell , organ , or organism at a given time . in general ,
proteomic approaches can be used ( a ) for proteome profiling , ( b ) for comparative expression analysis of two or more protein samples , ( c ) for the local... | proteomics is the large - scale study of the structure and function of proteins in complex biological sample .
such an approach has the potential value to understand the complex nature of the organism .
current proteomic tools allow large - scale , high - throughput analyses for the detection , identification , and... |
one of the major concerned questions in solid organ transplantation is how to establish long - term allograft survival that is free from immunosuppressive strategies . the most promising answer to
decades of years have witnessed the attempts to achieve this goal from cotransplantation with hematopoietic stem cell to ... | myeloid derived suppressor cells ( mdscs ) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions .
recent studies have uncovered the crosstalk between mdscs and immune cells ( i.e. , natural killer cells ... |
a 56-year - old male patient presented to our emergency department with chief complains of inability to void urine for 24 hours and vague abdominal pain .
he was diagnosed as a case of acute urinary retention and was referred to the surgical team for further management .
the surgical junior resident briefly examine... | emergency percutaneous trocar suprapubic cystostomy is a common surgical procedure for acute urinary retention . although uncommon it can be associated with a few complications .
the most dangerous complication is iatrogenic bowel injury .
literature shows reported cases of small and large bowel injuries .
we rep... |
celiac disease ( cd ) is an immune - mediated inflammation of the small intestine caused by sensitivity to dietary gluten in genetically sensitive individuals .
the disorder is common , occurring in 0.5 to 1 percent of the general population in most countries ( 1 ) .
overall , the global distribution of the disease... | background : celiac disease is an immune - mediated inflammation of the small intestine caused by sensitivity to dietary gluten in genetically sensitive individuals.objectives:in this study , we aimed to evaluate the predictive value of tissue transglutaminase ( ttg ) antibodies for the diagnosis of celiac disease in a... |
hydroxyapatite ( ha ; ca10(po4)6(oh)2 ) is a type of calcium phosphate that has extensive application in the healing of bones and teeth , due to its biocompatibility and similar composition to that of natural bone.15 one of the most common methods for the synthesis of hydroxyapatite and fluorapatite is the sol - gel me... | in this study , calcium phosphate nanoparticles with two phases , fluorapatite ( fa ; ca10(po4)6f2 ) and hydroxyapatite ( ha ; ca10(po4)6(oh)2 ) , were prepared using the solgel method .
ethyl phosphate , hydrated calcium nitrate , and ammonium fluoride were used , respectively , as p , ca , and f precursors with a c... |
the current study was performed as part of the maastricht aging study ( maas ) , a longitudinal study of determinants of cognitive aging ( 12 ) . a total of 10,396 people were sampled from the registration network family practices ( rnh ) , a patient register of collaborating general practitioners in the province of li... | objectiveto examine the effects of baseline and incident diabetes on change in cognitive function over 12 years.research design and methodsa sample of 1,290 individuals aged 40 years at baseline , participating in the maastricht aging study , were cognitively tested at baseline , after 6 years , and after 12 years .
... |
there is a societal trend towards increased awareness and emphasis on beauty and facial aesthetics .
accordingly , the facial profile is one of the most important factors to consider in orthodontic or orthognathic surgical patients.1 many studies have assessed anterior - posterior relationships of the maxilla and man... | objectivethe aims of this study were to investigate a simple method for assessing anterior - posterior jaw relationships via cone - beam computed tomography ( cbct ) images taken in the natural head position ( nhp ) relative to the nasion true vertical plane ( ntvp ) , and measure normative data in korean adults with n... |
the genus cymbopogon belongs to one of the most important essential oil yielding families of the poaceae and comprises nearly 140 species that are widely distributed in semitemperate to tropical regions of asia , africa , and america .
stapf is native from the southwest asia and now it grows spontaneously around the ... | cymbopogon citratus ( dc . )
stapf commonly known as lemon grass is used extensively as green tea and even as herbal tea ingredient across the world .
plants have the ability to uptake metals as nutrient from the soil and its environment which are so essential for their physiological and biochemical growth .
conc... |
the study subjects were pregnant women recruited from 2 medical institutions of obstetrics in osaka , japan . all subjects provided written informed consent after the nature and possible consequences of the study had been explained .
the study protocol was approved by the ethics committee at the osaka city university... | background .
pregnant women are a high - risk group for influenza - associated complications and hospitalizations.methods . to examine the immunogenicity of a monovalent 2009 influenza a ( h1n1 ) vaccine among pregnant women , a prospective cohort study was performed at 2 medical institutes of obstetrics in japan . ... |
the present classification of phacomatosis pigmentovascularis includes four distinct types , namely , phacomatosis cesioflammea , phacomatosis cesiomarmorata , phacomatosis spilorosea , and phacamatosis melanorosea .
an additional group comprises various unclassifiable forms of extensive capillary nevi coexisting wit... | a 2-month - old boy was presented with widespread lateralized blue macules ( nevus cesius ) , an extensive nevus flammeus , and large patches of cutis marmorata telangiectatica congenita .
moreover , he had macrocephaly , a coarse facial appearance with depressed nasal bridge , retinal abnormalities , septal defects ... |
influenza frequently results in the development of acute respiratory infection in children younger than 2 years , with a higher admission rate than that caused by respiratory syncytial virus infection1 ) . during an influenza epidemic ,
influenza - related morbidity increases significantly in children younger than 1 ... | influenza causes acute respiratory infections and various complications .
children in the high - risk group have higher complication and hospitalization rates than high - risk elderly individuals .
influenza prevention in children is important , as they can be a source infection spread in their communities .
infl... |
an increasing number of patients are visiting hospitals owing to abnormal posture and
idiopathic spinal deformities .
such conditions are especially serious for adolescents , who
are undergoing dramatic musculoskeletal growth .
this problem appears closely related to
lifestyle issues such as learning environm... | [ purpose ] this study compared the effects of swiss ball exercise and resistance exercise
on the respiratory function and trunk control ability of patients with scoliosis .
[ subjects ] forty scoliosis patients were randomly divided into the swiss ball exercise
group ( n= 20 ) and resistance exercise group ( n =... |
nowadays it is considered a valuable tool in the knowledge acquisition process for residents , fellows , and young surgeons .
different strategies are available to teach specific topics for surgeons such as courses , cadaver laboratories , and online presentations . however , the learning process is complex , and som... | study designpilot test , observational study.objectiveto evaluate objectively the knowledge transfer provided by theoretical and practical activities during aospine courses for spine surgeons.methodsduring two aospine principles courses , 62 participants underwent precourse assessment , which consisted of questions abo... |
diabetes is a common chronic condition which requires several complex self - care chores(1 ) .
it has been reported that the incidence of type 2 diabetes mellitus ( t2 dm ) is increasing in both industrialized and developing countries due to behavioral causes and changes in the life style ( 2 ) .
it has been expect... | background : self - care is an essential element in treating a person with diabetes ; and managing
diabetes is of prime importance . the aim of this study was to investigate the predictors of adherence
to self - care behavior among women with type 2 diabetes .
methods : this cross - sectional study was conducted ... |
apurinic / apyrimidinic endonuclease 1/redox factor-1 ( ape1/ref-1 ) , also known as apex1 , is the mammalian ortholog of escherichia coli xth ( exonuclease iii ) .
oxidative dna lesions , including apurinic / apyrimidinic ( ap ) sites , have been reported as occuring at an estimated rate of 1.510 residues / cell / d... | apurinic / apyrimidinic endonuclease 1/redox factor-1 ( ape1/ref-1 ) is a multifunctional protein that plays a central role in the cellular response to dna damage and redox regulation against oxidative stress .
ape1/ref-1 functions in the dna base excision repair pathway , the redox regulation of several transcriptio... |
in recent years expectations have been raised that stem cell replacement therapy could be used as a therapeutic approach to compensate for lost or damaged neuronal cells and to restore functionality in brain areas affected by chronic neurodegenerative diseases , such as alzheimer disease ( ad ) .
the accumulation of ... | stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in alzheimer 's disease ( ad ) .
this study investigated whether drugs with different mechanisms of action could enhance neurogenesis and improve cognition in mice receiving human neural... |
expert reviewing of
microscopic data is a well - known procedure in medical practice , within the
framework of cooperative studies with therapeutic , epidemiological , or
scientific purposes . in the current state of things , this notion , however ,
mostly remains a theoretical one owing to persisting ... | due to their high levels of achievement and efficiency , image digitalization and teletransmission tools are more and more frequently used .
applied to cellular haematology , these tools often contribute to diagnosis confrontation , sometimes within the framework of therapeutic trials .
we present one of the first ... |
the advent of the flexible endoscope and its world - wide use in clinical practice has had a major impact on the management of gastric cancer.(1 ) histopathologic diagnosis remains the foundation of clinical decision making in the treatment of gastric neoplasia .
however , based on subjective morphologic criteria , c... | although the biological potential of gastric epithelial dysplasia ( ged ) as a precursor of gastric cancer has never been in doubt , the classification of these lesions has been controversial and fraught with marked variations in approach to diagnosis across the world .
the complexity of cyto - architectural features... |
bladder cancer is one of the most frequent malignancies around the world ( 1 ) . in the united states ,
the estimated number of new cases for 2014 is 69,000 while the estimated number of deaths is approximately 15,000 ( 2 ) .
evidence suggests that the activation of the telomerase enzyme is a pivotal step in the de... | objective(s):genome - wide association studies have identified a number of genetic variants of telomerase reverse transcriptase ( tert ) , cleft lip and palate transmembrane1-like ( clptm1l ) associated with the risk of bladder cancer .
rs401681 polymorphism in tert - clptm1l was of special interest for bladder cance... |
the skin , a major site of defense against pathogenic agents , is exposed to a large number of environmental chemicals , some of which induce allergic reactions ( sensitizers ) .
, great efforts have been made to identify and quantitatively assess skin sensitizers , in view of the risk of unexpected exposure to ident... | backgroundskin sensitizers induce allergic reactions through the induction of reactive oxygen species .
allyl nitrile from cruciferous vegetables has been reported to induce antioxidants and phase ii detoxification enzymes in various tissues .
we assessed the effects of repeated exposure to allyl nitrile on sensiti... |
melanocortin-4 receptor ( mc4r ) is the cognate receptor for -melanocyte stimulating hormone ( -msh ) , a cleavage product of proopiomelanocortin ( pomc ) which is expressed in hypothalamic arcuate nuclei ( arc ) neurons ( 1 ) .
mc4r activation by agonists such as -msh inhibits feeding and causes weight loss ( 2 ) . ... | objective : melanocortin-4 receptor ( mc4r ) and agouti - related peptide ( agrp ) are involved in energy homeostasis in the rat .
the aim of the present study was to evaluate the expression of mc4r and agrp mrnas in arcuate nucleus ( arc ) during long term malnutrition of female ovariectomized rats.materials and met... |
since combination therapy with steroids and cyclophosphamide was first introduced , the prognosis for patients with anti -- neutrophil cytoplasmic antibody ( anca)-associated vasculitis has improved significantly [ 1 , 2 ] . however , the effectiveness of this therapy has proved to be limited , and adverse reactions to... | a 77-year - old man developed severe renal insufficiency due to proteinase 3 anti - neutrophil cytoplasmic antibody ( pr3-anca)-associated vasculitis , and was started on hemodialysis ( hd ) .
because his renal insufficiency appeared to be irreversible , he was maintained on oral prednisolone ( psl ) at 5 mg / day .... |
a prerecorded message instructed callers to contact their state or local health department if they had not done so .
calls that could be answered with frequently asked questions documents or guidelines published in the morbidity and mortality weekly report ( mmwr ) were handled directly by public health advisors , ... | after public notification of confirmed cases of bioterrorism - related anthrax , the centers for disease control and prevention s emergency operations center responded to 11,063 bioterrorism - related telephone calls from october 8 to november 11 , 2001 .
most calls were inquiries from the public about anthrax vaccin... |
triad has been described in detail elsewhere ( 2 ) . in 20002001 and 20022003 , surveys were administered by computer - assisted telephone interview or in writing by mail .
we included participants who had survey and medical record data at both baseline and follow - up ( n = 5,478 ) .
characteristics of the study p... | objectiveto determine whether competing demands for time affect diabetes self - care behaviors , processes of care , and intermediate outcomes.research design and methodswe used survey and medical record data from 5,478 participants in translating research into action for diabetes ( triad ) and hierarchical regression ... |
despite recent advances in treatment of non - small - cell lung cancer ( nsclc ) , almost all patients with metastatic or unresectable cases of nsclc inevitably experience disease progression .
in addition , as supportive care of patients with advanced cancer is developing , an increasing number of patients with adva... | purposethere is no regimen that is strongly recommended for more than second - line treatment .
we investigated the efficacy and safety of platinum / vinorelbine as more than second - line treatment.materials and methodswe selected patients with advanced non - small cell lung cancer ( nsclc ) who received treatment w... |
individuals with cancer commonly experience anorexia , weight loss , and wasting of muscle and adipose tissue [ 1 , 2 ] . these symptoms are also accompanied by a number of metabolic abnormalities , including alterations in carbohydrate , protein , and lipid metabolism , and insulin resistance [ 3 , 4 ] .
this syndro... | backgroundcancer cachexia is a complex syndrome associated with multiple metabolic abnormalities .
insulin resistance is present in many cancer patients and may be one mechanism through which muscle wasting occurs.methods and resultsthe present review examines evidence in support of a role for insulin resistance in t... |
presbycusis , or age related hearing loss , exerts a substantial socioeconomic impact , affecting over 25% of those 50 years old and over .
this loss manifests as progressive high - to - low frequency loss . clinically , there is difficulty in speech localization and sound discrimination .
the cause of presbycusis ... | introduction .
previous work has shown a strong association between alterations in cochlear vasculature , aging , and the development of presbycusis
. the important role of vascular endothelial growth factor ( vegf ) and its receptors flt-1 and flk-1 in angiogenesis suggests a potential role for involvement in this... |
however , recent studies showed that the adipose tissue is a highly active endocrine organ , which synthesizes and secretes a large number of proteins , such as leptin , resistin , adiponectin , angiotensinogen , and many others .
some of these proteins induce insulin resistance , others play a role in glucose and li... | leptin , like estrogen , is one of the endo / paracrine factors , which are synthesized in and secreted from mature adipocytes .
the roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear . in this study
, we showed that combination of prolactin , leptin and estrogen elevat... |
the discovery by cheresh and coworkers that antagonists specific for v3 or v5 selectively block angiogenesis induced by bfgf and vegf , respectively , provided some of the first support for a role of v integrins in angiogenesis and led them to postulate the existence of two separate angiogenic pathways ( friedlander et... | a vital step in growth factor
driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix .
the molecular mechanisms that partner growth factors and integrins are being elucidated , revealing an intricate interaction of surface receptors and their signaling pathways . |
although some reports describing the incidence of atrial fibrillation ( af ) after closure of interatrial septal communications ( iasc ) have been published , most of them have used a few well - established devices [ 13 ]
. some limitations of these studies have been acknowledged , the larger study choosing to omit a... | backgroundtranscatheter closure of interatrial septal communications ( iasc ) is being increasingly performed , while less is known about predictors and incidence of new onset atrial fibrillation ( af ) after device closure .
hitherto , most studies have only analyzed some parameters potentially influencing the occur... |
although pterygium excision with conjunctival autograft is a widely performed surgical procedure , surgically induced necrotizing scleritis ( sins ) following such surgery is extremely rare .
on postoperative day 17 , the conjunctival graft was avascular , with epithelial defect . although topical steroid and antibac... | backgroundalthough pterygium excision with conjunctival autograft is a widely performed surgical procedure , surgically induced necrotizing scleritis ( sins ) following such surgery is extremely rare.methodsa 68-year - old man underwent nasal pterygium excision with conjunctival autograft uneventfully . on postoperativ... |
cat and dog fleas are the most common parasites responsible for flea bite in humans .
cat flea bite results in extreme pruritis which may be prolonged if not identified early .
it requires appropriate medical management and eradication of fleas from the environment to achieve treatment success .
cat flea infestat... | cat flea bite in humans results in extremely pruritic skin lesions .
it has been reported to occur among those living in domiciliary accommodation . however , nosocomial infestation with cat flea has not been reported .
we hereby report a case of nosocomial infestation of cat flea in a hospital facility .
identif... |
schizophrenia , with a prevalence of about 1% among the general population , is one of the major mental health problems around the world .
the disease develops during childhood and adolescence . in the course of this disorder , the patient experiences recurrent relapses and long - term hospitalization , which lead to... | background : family psycho - education is one of the most effective interventions for preventing relapse in patients with schizophrenia .
we evaluated the efficacy of a needs - assessment based educational program in comparison with a current program ( textbook based ) in the treatment of schizophrenia.materials and... |
balance is indispensable to an individual s ability to safely and independently perform
activities of daily living such as moving or walking1 . in stroke patients , trunk muscle weakness and
the loss of
proprioception on the affected side can interfere with balance , stability , and functional
ability2 , 3 and ... | [ purpose ] this study performed a systematic literature review of the ability of lumbar
stabilization exercises ( lse ) to improve the balance ability of stroke patients . [ subjects
and methods ] a systematic review was conducted of four databases .
the papers retrieved
were evaluated based on the following i... |
alopecia areata ( aa ) is an autoimmune disorder cause of inflammation - inducednon - scarring type of hair loss , which consists of 1% patients referred to the dermatology clinic.1 aa due to the complications affects the patients quality of life and reduces their self - esteem.2 the life - time risk of aa is about 2.1... | background and objectives : alopecia areata ( aa ) is a common , non - scarring type of hair loss , affecting approximately 2.1% of the population , many modality of treatment recommended like steroid injection , topical immunotherapy and several systemic therapies .
the aim of this study was to compare intralesional... |
retinal prostheses are under investigation by several groups [ 1 , 2 ] , and some
preclinical and clinical trials have been reported [ 36 ] .
preclinical experiments
are intended to estimate the stimulation parameters and to evaluate the
efficacy and the safety of the devices and the clinical trials are aimed a... | this article reports on a retinal stimulation system for long - term use in animal electrical stimulation experiments .
the presented system consisted of an implantable stimulator which provided continuous electrical stimulation , and an external component which provided preset stimulation patterns and power to the i... |
in the last decades , deaths from stroke have declined . despite the decline in mortality
, the annual number of cases of stroke is expected to increase within the next few decades , mainly due to a 30 % growth in the elderly population .
stroke is a heterogeneous disorder consisting of three major pathological ty... | our aim was to prospectively ascertain the incidence of first - ever stroke and ischaemic stroke subtypes , mortality , functional outcome and recurrence in northern italy .
we identified all possible cases of stroke ( 1st january 2004 and 31st december 2008 ) .
multiple overlapping sources were used .
standard d... |
the prevalence and incidence of hypertension , arguably the most important modifiable risk factor for cardiac and cerebrovascular diseases , are going to increase dramatically worldwide over the next decade .
prevention and treatment of high blood pressure ( bp ) already represent a public health challenge in many ar... | the knowledge of each patient 's global risk profile is a prerequisite for effective therapeutic strategies in primary hypertension .
detecting the presence of subclinical organ damage at the cardiac , vascular , and renal levels is key for stratifying cardiovascular risk and may also be helpful in choosing antihyper... |
osteoblastoma ( ob ) is a benign tumor of bone characterized by osteoid and bone formation with the presence of numerous osteoblasts .
this tumor was first described by jaffe and mayer in 1932 . the current term benign osteoblastoma was proposed by jaffe and lichtenstein in two separate reports in 1956 .
, osteobla... | benign osteoblastoma ( ob ) is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region .
vertebral column , sacrum , long bones , and calvarium are more frequent sites of this tumor .
clinically , patients present with pain and swelling .
histologically , contain a well vasculariz... |
smoking causes a variety of disabilities in man . it kills more than five million people a year
an average of one person every 6 seconds and is responsible for one in ten adult deaths .
more than 80% of the one billion smokers worldwide live in low- and middle - income countries , where the burden of tobacco - rel... | background : genotoxic carcinogens in cigarette smoke interact with dna , causing cytotoxicity .
cytogenetic damage therefore seems to be an excellent biomarker for determining the effect of exposure to chromosome - damaging agents in cigarette smoke.purpose:to study the utility of measurement of frequency of satelli... |
worldwide reports have revealed that occurrence of such disorders are very low in populations where consanguinity is discouraged ( 1 ) .
however , in pakistan , high rate of consanguinity have resulted in comparative increase in probability of the disease occurrence .
wholly hair loss is generally considered to be ... | objective(s ) : genetic analysis of two consanguineous pakistani families with localized autosomal
recessive hypotrichosis was performed with the goal to establish genotype - phenotype correlation.materials and methods : genomic dna extraction had been done from peripheral blood samples .
extracted dna was then sub... |
a number of causes for these mutations have been described , including intrinsic mutation processes such as damage from endogenous reactive oxygen species or incomplete fidelity of the dna replication machinery and extrinsic factors such as environmental and lifestyle exposures .
for example , uv light and tobacco ex... | summarymutation is a fundamental process in tumorigenesis .
however , the degree to which the rate of somatic mutation varies across the human genome and the mechanistic basis underlying this variation remain to be fully elucidated . here
, we performed a cross - cancer comparison of 402 whole genomes comprising a ... |
in recent years , aesthetics has become increasingly important : everyone wants to be beautiful , according to modern society 's concept of beauty .
since a beautiful smile can make the difference , dental and oral implantology are no exception : patients have high aesthetic expectations of implant - prosthetic treat... | purpose . to evaluate the soft tissue stability around single implants inserted to replace maxillary lateral incisors , using an innovative 3d method
. methods . we have used reverse - engineering software for the superimposition of 3d surface models of the dentogingival structures , obtained from intraoral scans of ... |
one of the main steps of the root canal treatment is to provide the suitable conditions for periapical tissues to heal up by biomechanical instrumentation of the root canal system . during the instrumentation , necrotic debris , residual pulp tissue , microorganisms , dentin chips , or irrigation solutions
this situa... | background / aim : to compare apically extruded debris using protaper universal ( ptu ) , protaper next ( ptn ) , waveone ( wo ) , twisted file ( tf ) , m - two ( mt ) , and revo - s ( rs ) after determining the working length ( wl ) with root zx.materials and methods : seventy - two teeth were selected . the wl determ... |
primary data collection , whereby researchers collect information on subjects for purposes of analysis within a study , remains a core and necessary requirement for many clinical research studies , even with the expanded secondary use of electronic health information for research .
the costs of collecting and managin... | next - generation tablets ( ipads and android tablets ) may potentially improve the collection and management of clinical research data .
the widespread adoption of tablets , coupled with decreased software and hardware costs , has led to increased consideration of tablets for primary research data collection .
whe... |
pseudomonas aeruginosa is an oxidase positive , glucose non - fermenting gram negative bacillus that normally inhabits soil and aquatic environments .
its large genome , adaptive regulatory systems , metabolic versatility and high intrinsic antibiotic resistance , facilitates its survival in a diverse range of habita... | respiratory infections caused by pseudomonas aeruginosa are a major clinical problem globally , particularly for patients with chronic pulmonary disorders , such as those with cystic fibrosis ( cf ) , non - cf bronchiectasis ( ncfb ) and severe chronic obstructive pulmonary disease ( copd ) .
in addition , critically... |
prostate cancer is the most common malignancy in the united state . in 2009 , 192,280 men were estimated to have been diagnosed with prostate cancer , and 27,360 of these patients died in the united states .
the prostate - specific antigen ( psa ) is used for the detection of prostate cancer in daily practice , but i... | serum prostate - specific antigen ( psa ) levels ranging from 4 to 10 ng / ml is considered a diagnostic gray zone for detecting prostate cancer because biopsies reveal no evidence of cancer in 75% of these subjects .
our goal was to discover a new highly specific biomarker for prostate cancer by analyzing plasma pr... |
modification of otherwise soluble proteins with hydrophobic moieties , such as myristoyl or isoprenyl groups , is essential for their targeting to cell membranes .
in contrast , thioester linkage of palmitate , a c16 saturated fatty acid , to cysteine residues ( s - palmitoylation ) is a reversible modification catal... | s - palmitoylation is a posttranslational modification that regulates membrane protein interactions .
however , palmitate is more than just a hydrophobic membrane anchor , as many different types of protein are palmitoylated , including transmembrane proteins .
indeed , there is now compelling evidence that palmit... |
thyroid eye disease ( ted ) is an autoimmune inflammatory disorder involving the orbital tissues .
it is the most common extrathyroidal manifestation of graves disease but may also be associated with hashimoto s thyroiditis.13 although its pathogenesis is not completely understood , autoimmune activation of pre - adi... | purposeto examine the relationships between sex and symmetry in the context of disease activity , severity , and thyroid status in thyroid eye disease.methodsretrospective chart review of 31 men and 31 women with untreated thyroid eye disease .
subjective complaints , smoking status , thyroid status , and objective f... |
the application of wireless telemedicine in monitoring patients is seen as a useful and potentially powerful tool to help patients seek medical treatment [ 1 , 2 ] . in remote monitoring systems of asthmatic patients ,
cough signals ( as well as other body vital signs ) are collected by sensors attached to the patien... | this paper aims to study the performance of support vector machine ( svm ) classification in detecting asthma attacks in a wireless remote monitoring scenario .
the effect of wireless channels on decision making of the svm classifier is studied in order to determine the channel conditions under which transmission is ... |
in this issue of critical care , dale rublee and colleagues look beyond 28-day all - cause mortality , assessing the effects of antithrombin iii on quality of life in sepsis survivors .
although many of us would like to think that the battle has been won when a patient leaves the intensive care unit ( icu ) after sev... | a growing body of evidence indicates that survivors of intensive care have an impaired quality of life .
it is not entirely clear from the available literature whether this impairment is a complication of critical illness or a complication of therapy .
there is little evidence to guide physicians to treatments in t... |
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