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one hundred fifteen eyes from 90 patients with exudative amd were imaged and enrolled at the bascom palmer eye institute in a prospective oct imaging study from october 2015 to april 2016 .
the institutional review board of the university of miami miller school of medicine approved the study , and an informed consent... | purposeto compare the lesion sizes of choroidal neovascularization ( cnv ) imaged with spectral - domain ( sd ) and swept - source ( ss ) optical coherence tomography angiography ( octa ) and measured using an automated detection algorithm.methodspatients diagnosed with cnv were imaged by sd - octa and ss - octa system... |
a 57-year - old caucasian male was admitted with suspected acute coronary syndrome , primarily because of pronounced st segment elevations in the precordial ekg leads ( figure 1 ) . the day before admission he experienced two episodes of chest pain while walking .
the pain was dull , at a maximum intensity 5/10 on th... | a 57-year - old male was admitted with suspected acute coronary syndrome .
he reported experiencing moderate chest pain when walking during the day prior to admission , but had very prominent st segment elevations in the precordial electrocardiography ( ekg ) leads .
a physical examination revealed remarkable sever... |
inositol phosphates are important intracellular
messengers that
play a vital role in many cellular functions including cell growth ,
migration , differentiation , apoptosis , and endocytosis . to facilitate biochemical investigations , it is vital that efficient
routes to these naturally occurring inositol phos... | acid
hydrolysis of myo - inositol 1,3,5-orthoesters ,
apart from orthoformates , exclusively affords the corresponding 2-o - acyl myo - inositol products via a 1,2-bridged
five - membered ring dioxolanylium ion intermediate observed by nmr
spectroscopy .
these c-2-substituted inositol derivatives provide valu... |
contamination of foods by mycotoxins is an important food safety concern for grains and other agricultural products .
food contaminated with mycotoxins , particularly with aflatoxins , can cause sometimes fatal acute illness , and are associated with increased cancer risk ( 1 ) .
every year a significant percentage... | background and objectivesfood contamination by aflatoxins is an important food safety concern for agricultural products . in order to identify and develop novel antifungal agents , several plant extracts and isolated compounds have been evaluated for their bioactivities .
anti - infectious activity of piper betle use... |
targeted therapy has been proven to be one of the most successful treatment modalities in many cancers .
however , some endocrine disorders have been associated with treatment with targeted agents , including hypothyroidism ( sunitinib and pazopanib ) , hypoglycemia ( sunitinib ) , and hyperglycemia ( everolimus ) . ... | targeted therapy has been proven to be one of the most effective cancer treatments .
however , some endocrine disorders can occur during treatment with targeted agents .
we report the case of a patient who exhibited a wax and wane pattern of hypoglycemia that was attributed to sorafenib therapy . a 32-year - old wo... |
inflammatory bowel disease ( ibd ) , which includes ulcerative colitis ( uc ) and crohn 's disease ( cd ) is a chronic disease described by the improper immune response which causes inflammatory lesions in the gastrointestinal tract .
however , environmental , immune , and genetic factors have all been involved in it... | background : treating inflammatory bowel disease ( ibd ) with antidepressants might be of utility to improve patient 's condition .
the aim of this study was to assess the efficacy of duloxetine on depression , anxiety , severity of symptoms , and quality of life ( qol ) in ibd patients.materials and methods : in a r... |
a total of 422 patients were recruited between 1998 and 2010 ; 168 were recruited at the london centre of pediatric endocrinology , based at great ormond street hospital for children and university college london ( ucl ) hospitals in london ; the remainder were referred from national ( n = 157 ) and international ( n =... | context : loss - of - function mutations in prok2 and prokr2 have been implicated in kallmann syndrome ( ks ) , characterized by hypogonadotropic hypogonadism and anosmia .
recent data suggest overlapping phenotypes / genotypes between ks and congenital hypopituitarism ( ch ) , including septo - optic dysplasia ( sod... |
an explosive fatal epizootic in poultry , prairie chickens , turkeys , ducks , and geese occurred over much of the populated united states between november 15 and december 15 , 1872 .
the epizootic progressed in temporalgeographic association with a wellreported panzootic of equine influenza , which had begun in or a... | please cite this paper as : morens and taubenberger ( 2010 ) an avian outbreak associated with panzootic equine influenza in 1872 : an early example of highly pathogenic avian influenza ? influenza and other respiratory viruses 4(6 ) , 373377 .
background an explosive fatal epizootic in poultry , prairie chickens ,... |
the dutch population - based dcis cohort consists of 10468 female patients diagnosed with dcis as their first neoplasia before the age of 75 years between 1989 and 2004 .
the ncr has a coverage of at least 96% of invasive malignant neoplasms and selected noninvasive cancers , including dcis , occurring in the netherl... | backgroundrecent concerns about potential overdiagnosis and overtreatment of ductal carcinoma in situ of the breast ( dcis ) render evaluation of late effects of treatment , such as cardiovascular disease ( cvd ) , of great importance .
we studied cardiovascular morbidity and mortality in a large population - based c... |
traditional laboratory - based cancer research involves expensive trial and error experimental strategies applied to humans , animals , and their harvested tissues . in silico experimentation , the coupling of current computing technologies with mathematical or theoretical characterizations of cancer cell biology , p... | in silico experimental modeling of cancer involves combining findings from biological literature with computer - based models of biological systems in order to conduct investigations of hypotheses entirely in the computer laboratory . in this paper , we discuss the use of in silico modeling as a precursor to traditiona... |
soluble amyloid oligomers
are now thought to be the main toxic
species that cause neurodegeneration in alzheimer s and other
amyloid diseases .
small assemblies made up of dimers , trimers , and tetramers of the
-amyloid peptide ( a ) , as well as larger assemblies such
as dodecamers , have been shown to di... | this
contribution reports solution - phase structural studies of
oligomers of a family of peptides derived from the -amyloid
peptide ( a ) .
we had previously reported the x - ray crystallographic
structures of the oligomers and oligomer assemblies formed in the
solid state by a macrocyclic -sheet peptide c... |
small - incision lenticule extraction ( smile ) was carried out using the visumax femtosecond laser ( carl zeiss meditec ag , jena , germany ) , a femtosecond laser - based corneal refractive surgical procedure for myopia and myopic astigmatic correction.1,2 during the smile technique , after application of the topical... | purposeto evaluate refractive outcomes of two management approaches after suction loss during the small - incision lenticule extraction ( smile ) technique.patients and methodsthis retrospective and comparative study was conducted at the el - gowhara private eye center .
it included 26 consecutive eyes of patients wh... |
styloid process is derived from the greek word stylos means a pillar , which is normally a cylindrical structure arising from the temporal bone anterior to stylomastoid foramen .
the apex of the styloid process is clinically important as it is located between internal and external carotid arteries .
the tip of th... | objective : the study was performed to investigate the prevalence , morphology and calcification pattern of elongated styloid process in saudi population of aseer ( southern ) region and its relation to gender and sub - age groups.materials and methods : this study was analyzed digital panoramic radiographs of 1,162 ad... |
the epidemiology of nasopharyngeal carcinoma ( npc ) is characterized by its unique geographic distribution .
decades of epidemiological studies have shown that npc has unique prevalence features , including regional , racial and familial aggregation . according to the global registry of cancer incidence
, npc rank... | nasopharyngeal carcinoma ( npc ) has remarkable epidemiological features , including regional , racial , and familial aggregations .
the aim of this review is to describe the epidemiological characteristics of npc and to propose possible causes for the high incidence patterns in southern china .
since the etiology ... |
arrhythmic disorders are responsible for 2,000 - 3,000 deaths out of 55,000 - 60,000 cardiovascular disorder related death per year during last decade in korea
. one of the arrhythmic disorders , long qt syndrome ( lqts ) , is an inherited disorder characterized by the prolongation of the qt interval in the electroca... | long qt syndrome ( lqts ) is characterized by the prolongation of the qt interval in ecg and manifests predisposition to life threatening arrhythmia which often leads to sudden cardiac death .
we encountered a 3-generation family with 5 affected family members in which lqts was inherited in autosomal dominant manner ... |
the health care sector includes a diverse range of health care facilities , which have a size assortment from large general and specialist hospitals to small municipal dispensaries and d - type centers .
all these facilities are an integral part of our society with an endeavor to reduce health problems and to elimina... | background : dental operatories pose a threat due to the high chances of infection transmission both to the clinician and the patients .
hence , management of dental waste becomes utmost importance not only for the health benefit of the dentist himself , but also people who can come into contact with these wastes dir... |
the dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue , gray , or white colors .
a female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior .
her past medical history was significant ... | backgroundhypomelanotic or amelanotic melanomas are challenging to identify , especially at mucosal sites .
the dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue , gray , or white colors.casea female in her seventies noted a new lesion on th... |
the number of dialysis patients with end - stage renal failure increases by more than 4% per year in sweden , with a current prevalence of 900 dialysis patients per million inhabitants .
these patients are always concerned about the function of their vascular access because their quality of life depends on it .
pta... | purpose . our objective was to evaluate the outcome of percutaneous transluminal angioplasty ( pta ) and particularly repta in a failing arteriovenous fistula ( av - fistula ) .
are multiple redilations worthwhile ?
patients and methods .
all 159 stenoses of av fistulas that were treated with pta , with or withou... |
globally , stroke is the third major cause of mortality and a major health issue in low- and middle - income countries like india .
eighty percent of stroke survivors experience motor impairments ( hemiparesis ) typically affecting movement of the face , arm , trunk , and leg of one side of the body often persistent ... | background : eclectic treatment method is a flexible approach that uses techniques drawn from various schools of thought involving several treatment methods and allows the therapist to adapt to each client 's individual needs .
wider application for eclectic approach is however limited in stroke rehabilitation.aim:th... |
as the primary fuel for abiding sports , carbohydrate intake before , during , and after exercise , has a positive effect on endurance performance [ 16 ] .
apart from being an energy substrate , the sight , smell , and taste of food may act as positive reinforcements . by generating promises for food intake , the... | background .
oropharyngeal receptors signal presence of carbohydrate to the brain .
mouth rinses with a carbohydrate solution facilitate corticomotor output and improve time - trial performance in well - trained subjects in a fasted state .
we tested for this effect in nonathletic subjects in fasted and nonfasted... |
scorpion envenomation ( se ) is a public health problem especially in tropical and subtropical countries .
the majority of cases are admitted with pain localised to the site of the sting , and then follow a benign clinical course ( dittrich et al . , 2002 ) . however , severe envenoming may present cardiac and respir... | the aim of this study was to assess the correlation between platelet indices and scorpion envenomations ( se ) .
medical records of 76 children who were hospitalised for scorpion stings in the paediatric intensive care unit ( picu ) between february 2013 and november 2013 , and 55 healthy children who were similar to... |
anterior cervical discectomy and fusion ( acdf ) is a common surgical procedure used in the treatment of many cervical spine disorders ; herniated discs , spondylosis , fractures , and neoplastic lesions15 ) . since initially reported in 1955 by robinson and smith19 )
, acdf has become an accepted procedure for decom... | objectivethe purpose of this study is to verify the usefulness of autograft versus allograft in the radiographic and clinical outcome in early period after the surgery.methodswe performed a retrospective review of 38 patients who had undergone one- or two - level anterior cervical discectomy and fusion ( acdf ) with ri... |
this study was performed at the olympic village polyclinic during the 2002 winter olympiad in salt lake city , utah , usa , during february and march 2002 .
athletes and nonathletes with upper / lower respiratory symptoms ( with or without febrile / systemic illness ) were screened for influenza by various modalities... | prospective surveillance for influenza was performed during the 2002 salt lake city winter olympics .
oseltamivir was administered to patients with influenzalike illness and confirmed influenza , while their close contacts were given oseltamivir prophylactically .
influenza a / b was diagnosed in 36 of 188 patients... |
mitochondria play a fundamental role in cells , serving as the powerhouses that produce atp through the process of oxidative phosphorylation .
in addition to supplying cellular energy , mitochondria are involved in the response to several cellular stresses , such as cell death signaling and antiviral immunity [ 13 ... | to maintain cellular homeostasis , cells are equipped with precise systems that trigger the appropriate stress responses .
mitochondria not only provide cellular energy but also integrate stress response signaling pathways , including those regulating cell death .
several lines of evidence suggest that the mitochon... |
endometrial cancer ( ec ) is the most common gynecologic malignancy , frequently presenting in early stages . for women with localized disease at diagnosis ,
5-year survival rates exceed 90% ( siegel et al . , 2014 ) . for those with distant disease at diagnosis ,
while early disease is often cured by primary surge... | the objective of this study is to evaluate the association between tumor grade and response to chemotherapy in patients with endometrioid endometrial adenocarcinoma.patients with advanced or recurrent endometrioid endometrial adenocarcinoma of known tumor grade who received at least 3 cycles of chemotherapy were retros... |
acinetobacter baumannii is an omnipresent nonfermentative gram negative microorganism that frequently colonizes in the skin and upper respiratory tract of hospitalized patients . in two recent decades
multiple antibiotic - resistant strains of this microorganism have been implicated in nosocomial infections occurring... | background : the purpose of this study was to screen of parc gene mutations in clinical isolates of acinetobacter baumannii from intensive care units ( icus ) of alzahra hospital , isfahan , iran.materials and methods : seventy isolates of a. baumannii between march 2011 and june 2012 were studied .
susceptibility te... |
surgical site infection ( ssi ) is a commonly reported source of postsurgical morbidity . in breast surgery ,
three separate reviews of the national surgical quality improvement program ( nsqip ) database demonstrated ssi rates of 1.4%3.2% [ 13 ] . despite the relatively low ssi rates in registry data , other studies... | background .
antibiotic prophylaxis for surgical site infections ( ssis ) for breast surgery is widespread , but the benefit in clean surgical cases is not well defined
. methods . a retrospective analysis of 855 patients undergoing elective , nonreconstructive breast operations was performed , with 401 patients re... |
the hallmark characteristic of keratoconus ( kc ) is the development of localized , cone - shaped ectasia accompanied by corneal thinning in the area of the cone .
this leads to irregular astigmatism and steeper corneal curvature over the area of the cone .
the early detection of these changes is usually based on p... | purpose . to evaluate accuracy of various keratoconus ( kc ) screening indices , in relation to topographic keratoconus ( tkc ) grading . setting .
al watany eye hospital , cairo , egypt .
methods .
data of 103 normal ( group 1 ) and 73 kc eyes ( group 2 ) , imaged by pentacam ( branded as allegro oculyzer ) , we... |
desmoid tumors ( dts ) , also known as aggressive fibromatoses , are characterized as rare , slow - growing tumors .
although strictly benign , they are locally invasive with a high rate of recurrence even after seemingly total resection.1 dts typically develop sporadically , often in the abdomen , hip / buttocks are... | study design case report .
objective the objective of the article is to illustrate a case of desmoid tumor ( dt ) formation after posterior instrumentation of the thoracic spine .
methods a 57-year - old woman presented with lower extremity clumsiness , balance , and ambulation difficulty resulting from spinal c... |
alzheimer s disease ( ad ) is the
most common form of dementia
and the sixth - leading cause of death in the u. s. , affecting 5
million people in the u. s. , with a care cost of $200 billion
in 2012 .
analysis of familial early onset ad
patients identified the association of three disease genes , including... | the
accumulation of pathologic protein fragments is common in neurodegenerative
disorders .
we have recently identified in alzheimer s disease
( ad ) the aggregation of the u1 - 70k splicing factor and abnormal rna
processing . here , we present that u1 - 70k can be cleaved into an n - terminal
truncation (... |
this neurological disease is
associated with physical , cognitive , perceptual , and sensory dysfunctions2 .
therefore , the evaluation system should test cognitive impairment ,
which is an invisible risk factor for unsafe driving4 .
the on - road test is considered the gold - standard of testing driving func... | [ purpose ] this study examined the cut - off point of the trail making test in predicting
the risk of unsafe driving in stroke patients . [ subjects and methods ] a total of 81 stroke
patients with a driver s license participated in this study .
the driveable cognitive
assessment tool , trail making test - a ,... |
the spread of cancer to secondary sites ( metastasis ) is the main cause of morbidity for patients with solid tumors .
understanding of the molecular and cellular mechanisms that underpin tumor metastasis is therefore an important goal in cancer biology . over a century
ago , stephen paget proposed a seed and soil... | metastasis the spread of cancer cells to distant organs , is the main cause of death for cancer patients .
metastasis is often mediated by lymphatic vessels that invade the primary tumor , and an early sign of metastasis is the presence of cancer cells in the regional lymph node ( the first lymph node colonized by me... |
familial hypercholesterolaemia ( fh ) is an autosomal co - dominant monogenic disorder of lipoprotein metabolism .
it is characterised by severely elevated levels of low - density lipoprotein cholesterol ( ldl - c ) from birth onwards , clinically leading to premature atherosclerosis and cardiovascular disease ( cvd ... | backgroundin the netherlands , a screening programme was set up in 1994 in order to identify all patients with familial hypercholesterolaemia ( fh ) .
after 15 years of screening , we evaluated the geographical distribution , possible founder effects and clinical phenotype of the 12 most prevalent fh gene mutations.... |
the tradescantia genetic system developed by the late dr .
arnold h. sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection .
early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x - rays and that the number of cells sho... | |
pulmonary sclerosing hemangioma ( psh ) is a relatively rare benign tumor , which was first described by liebow and hubbell in 1956 .
most patients are asymptomatic , with less than one - third experiencing hemoptysis , coughs , or chest pain .
most cases of psh appear on computed tomography ( ct ) scans of the che... | pulmonary sclerosing hemangioma ( psh ) , or the alternative name of sclerosing pneumocytoma , is a rare benign neoplasm .
psh is often asymptomatic and presents as a solitary or multiple pulmonary nodules on radiologic imaging studies .
few articles have been reported to describe the fluorodeoxyglucose positron ... |
colon cancer frequency has continued to increase in japan in recent years , becoming the third highest cause of cancer death in males and number one in females in 2014 .
every year , there are over 40,000 deaths due to colon cancer , and reducing mortality rates has become a major goal.1,2 excision of colon polyps us... | purposeto investigate which colonoscopy ( cs ) cases should be presided over by endoscopists in training , using factors including obesity and metabolic syndrome.patients and methodsitems investigated were sex , age , body mass index ( bmi ) , waist circumference , hypertension , diabetes , hyperlipidemia , history of ... |
retail meats were obtained from 2 randomly selected census divisions per week from various retailers across canada as part of the active retail surveillance component of the canadian integrated program for antimicrobial resistance surveillance ( cipars ) ( 5 ) .
we tested random packages of ground beef as well as vea... | we previously reported clostridium difficile in 20% of retail meat in canada , which raised concerns about potential foodborne transmissibility . here , we studied the genetic diversity of c. difficile in retail meats , using a broad canadian sampling infrastructure and 3 culture methods .
we found 6.1% prevalence an... |
briefly , kidney cortices from mice were dissected , sliced , minced and digested in 0.25% trypsin solution ( life technologies brl , grand island , ny ) in a shaking incubator at 37 c for 1 h. trypsin was neutralized with growth medium ( dmem and 10% fbs containing 100 u / ml penicillin and 0.1 mg / ml streptom... | to assess the effect of farnesoid x receptor ( fxr ) , a bile acid nuclear receptor , on renal proximal tubular cells , primary cultured mouse kidney proximal tubular cells were treated with gw4064 ( a fxr agonist ) or dmso ( as controls ) overnight .
analysis of gene expression in the proximal tubular cells by whole... |
in cellular compartments ,
the presence of high concentrations of
bystander macromolecules ( or crowders ) may significantly affect protein
folding and binding free energies .
earlier modeling of crowding
effects focused on hard - core repulsion between the test protein and
the crowders .
recent experimen... | recently ,
we ( qin , s. ; zhou , h. x. j. chem .
theory comput.2013 , 9 , 46334643 ) developed
the fft - based method for modeling atomistic proteins
crowder interactions , henceforth fmap . given its potential
wide use for calculating effects of crowding on protein folding and
binding free energies , here... |
fungal infections have become an important cause of morbidity and mortality in recent years , especially in immunocompromised patients .
they usually occur as laboratory contaminants of sterile solutions and clinical specimens . in immunocompromised individuals ,
five species in the genus paecilomyces which cause i... | paecilomyces is a colonizing fungal species which usually causes keratitis , endocarditis , sinusitis , nephritis , fungemia , cutaneous , and subcutaneous infections in immunocompromised host .
very rarely , it causes similar infection in immunocompetent host without any risk factors .
we report a case of maxillar... |
lichen sclerosus et atrophicus ( lsa ) is a rare chronic inflammatory dermatosis with anogenital and extragenital involvement .
extragenital lichen sclerosus is most common on the neck , shoulders , and upper portion of the trunk .
it is generally asymptomatic or is occasionally pruritic and presents as flat , whit... | lichen sclerosus et atrophicus ( lsa ) is a chronic inflammatory dermatosis of unknown etiology .
extragenital involvement is uncommon and commonly affects the neck , shoulders , and upper portion of the trunk .
it is predominant in women with a male - to - female ratio of 1:6 and occurs at any age .
linear patte... |
low vision is a term generally used for long - lasting vision loss uncorrectable by medications , surgery or glasses .
low vision assistive device technology has progressed over the years to provide a variety of visual aids .
low vision assistive devices such as telescopic and microscopic lenses , hand and stand ma... | purpose : to investigate the effect of tinted filters on visual acuity ( va ) , contrast sensitivity and patient satisfaction in diabetic retinopathy associated with low vision.methods:in a prospective study , 51 patients with diabetic retinopathy and low vision were assessed .
we chose a simple random sampling metho... |
a 91-year - old female patient with a chief complaint of a mild febrile sensation and general weakness that lasted for two days was admitted to the emergency room at another hospital .
the patient had hypertension controlled by the beta blocker bevantolol , and dementia controlled by donepezil and risperidone .
she... | as an emergency encountered in orthopedic practice requiring prompt diagnosis and aggressive treatment , necrotizing fasciitis around the hip must be discriminated from fournier gangrene .
the current case report describes a patient who suffered from bilateral type i necrotizing fasciitis around the hips , which was ... |
systemic lupus erythematous ( sle ) is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue - binding auto antibodies and immune complexes .
primary adrenal insufficiency ( addison 's disease ) is most commonly caused by autoimmune processes either as isolated autoimmune adrenal... | coexistence of addison 's disease and systemic lupus erythematosus ( sle ) is a rare occurrence with only few reported cases in the literature .
we describe a 29-year - old woman who presented to us with clinical features of acute addisonian crisis and sle .
laboratory investigations were confirmatory of addison 's... |
pulmonary hypertension ( ph ) is a hemodynamic and pathophysiological condition defined as an increase of mean pulmonary pressure more than or equal to 25 mmhg at rest ( 1 , 2 ) . ph in children is mostly often related to the occurrence of heart disease and lung diseases ( secondary ) , while it rarely occurs as a prim... | pulmonary hypertension is a pathophysiological state hemodynamically defined as the increase of the mean pulmonary arterial pressure above 25 , or 30 mmhg at rest , measured by catheterization of the right heart .
laboratory findings usually reveals polycythemia , the ecg right ventricle hypertrophy , and x - ray cha... |
to report the clinical and diagnostic findings of a patient with acanthamoeba keratitis resistant to both polyhexamethylene biguanide ( phmb)-hexamidine and chlorhexidine - hexamidine treatment .
slit - lamp biomicroscopy , corneal cell scraping and histopathology were performed on a 39-year - old woman presenting wi... | aimsto report the clinical and diagnostic findings of a patient with acanthamoeba keratitis resistant to both polyhexamethylene biguanide ( phmb)-hexamidine and chlorhexidine - hexamidine treatment.methodsslit-lamp biomicroscopy , corneal cell scraping and histopathology were performed on a 39-year - old woman presenti... |
miller fisher syndrome ( mfs ) is characterized by the acute onset of external ophthalmoplegia , ataxia of cerebellar type , and the loss of tendon reflexes .
it is considered a variant of guillain - barr syndrome ( gbs ) , because some patients who present with mfs progress to gbs . in contrast , patients who show d... | we report a 72-year - old woman with overlapping miller fisher syndrome ( mfs ) , guillain - barr syndrome ( gbs ) and bickerstaff 's brainstem encephalitis ( bbe ) .
she developed diplopia and unsteady gait a week after an upper respiratory infection on day 1 .
she had weakness of both upper limbs on day 3 and bec... |
coronary - pulmonary artery fistulas are rare and usually arise from the left anterior descending or the right coronary artery .
they are mostly asymptomatic , but the clinical presentation could include dyspnea , angina , endocarditis , arrhythmias , heart failure , myocardial ischemia , or myocardial infarction.1 )... | we report the case of a man who presented with acute anterior myocardial infarction and in whom the coronary angiogram showed tight stenosis of the left anterior descending coronary artery and the right coronary artery associated with substantial coronary - pulmonary fistulas involving all three major coronary arteries... |
during the past few years , partially stabilized zirconia has been integrated into restorative dentistry.1 yttrium - oxide partially stabilized zirconia ( y - tzp ) has mechanical properties that are attractive for restorative dentistry ; namely , its chemical and dimensional stability , high mechanical strength , and ... | purposethe aim of this study was to measure the changes on the marginal and internal adaptation of zirconia based anterior fixed partial dentures after the porcelain firing process.materials and methodsa total of 34 anterior fixed partial dentures using lava cad / cam system ( 3 m espe , germany ) were applied .
two ... |
there is no debate that asa reduces mortality in secondary prevention of cardiovascular disease ( cvd ) , but an important question is why some patients do not benefit from asa therapy .
it was suggested that diabetic patients not treated with aspirin therapy display increased platelet reactivity , and that aspirin t... | aspirin has lower antiplatelet activity in diabetic patients .
our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease . using urine thromboxane ( pg / mg creatinine ) and verifynow ( aspirin resistance measures - aru ) ,... |
southeast asia is one of the hot spots of the diabetes pandemic and bears more than its fair burden of the disease .
belonging to the western pacific region of the international diabetes federation , the zone reports a diabetes prevalence of 9.3% and a large number of deaths , most of which occur in individuals below... | southeast asia faces a diabetes epidemic , which has created significant challenges for health care .
the unique asian diabetes phenotype , coupled with peculiar lifestyle , diet , and healthcare - seeking behavior , makes it imperative to develop clinical pathways and guidelines which address local needs and require... |
rheumatoid arthritis ( ra ) is a common chronic inflammatory disease associated with progressive joint destruction , pain , fatigue and disability .
current treatments target the inflammatory response using disease - modifying anti - rheumatic drugs ( dmards ) and biological agents , in combination or as monotherapy ... | tocilizumab ( tcz ) and tumour necrosis factor inhibitors ( tnfi ) are recommended for the treatment of rheumatoid arthritis ( ra ) in patients with inadequate response ( ir ) to prior disease - modifying antirheumatic drugs ( dmards ) .
this retrospective analysis assessed the efficacy of tcz and tnfi , alone or in ... |
lung cancer is one of the most common cancers and cause of cancer - related deaths worldwide 1 , 2 because of its extremely poor prognosis .
approximately 82.6 ( male ) and 30.1 ( female ) per 100,000 people die each year due to lung cancer in japan 3 .
lung cancer treatment regimens are determined by the histologi... | background : lymphatic vessel endothelial hyaluronan receptor-1 ( lyve-1 ) is a hyaluronic acid receptor that is selectively expressed in the endothelia of lymphatic capillaries .
the density of lymphatic vessels expressing lyve-1 on immunohistochemistry negatively correlates with prognosis of patients with non - sma... |
the first patient was a 41-year - old woman from rankin inlet , nunavut , canada , who noticed floaters ( objects in the field of vision that originate in the vitreous ) in her right eye in august 2006 .
her visual acuity was 20/400 ; funduscopic examination showed an intraocular larva ( figure 1 ) .
a pars plana v... | human myiasis caused by bot flies of nonhuman animals is rare but may be increasing . the treatment of choice is laser photocoagulation or vitrectomy with larva removal and intraocular steroids .
ophthalmomyiasis caused by hypoderma spp . should be recognized as a potentially reversible cause of vision loss . |
members of the family bromeliaceae can be epiphytic , terrestrial or saxicolous . the taxon is essentially neotropical , with more than 3,100 described species distributed in 58 genera . in brazil , where 40 % of these species are found ,
the highest diversity is in the atlantic forest (
givnish et al . 2011 ) .
... | background : bromeliads can be epiphytic , terrestrial or saxicolous and use strategies to allow water to be retained in their leaf axils , where various arthropods can be found .
these include mosquitoes , whose larvae are the most abundant and commonly found organisms in the leaf axils .
the objective of this stu... |
we
report the experimental realization of an optical metamaterial
composed of a hexagonal array of coaxial plasmonic metal / insulator / metal
waveguides that shows strong polarization - independent optical mode
index dispersion in the ultraviolet / blue .
the metamaterial is composed
of silicon coaxes with... | |
hepatitis c virus ( hcv ) infection is a major cause of chronic liver disease worldwide , and about 3% of the global population is estimated to have chronic hcv infection .
chronic hcv infection can progress to liver cirrhosis in about 15 - 56% over periods of 20 - 25 years .
annual incidence of hepatic decompensat... | chronic hepatitis c virus ( hcv ) infection is a major cause of liver cirrhosis and hepatocellular carcinoma .
combination therapy of pegylated interferon - alpha ( peg - ifn- ) and ribavirin ( rbv ) is a current standard treatment for chronic hcv infection in korea , which has considerable adverse effects .
acute ... |
in recent years , there has been much interest focused on the influence of nanotopography on cells because this surface feature is in the range of their sensing apparatus .
a variety of nanotopographies have now been shown to provide cues that affect gene expression and influence cell destiny and activity.1 this rema... | mesoporous surfaces generated by oxidative nanopatterning have the capacity to selectively regulate cell behavior , but their impact on microorganisms has not yet been explored . the main objective of this study was to test the effects of such surfaces on the adherence of two common bacteria and one yeast strain that a... |
data for this retrospective cohort study were obtained from the research patient database registry ( rpdr ) and point - of - care glucose meter download data for patients admitted to the brigham and women s hospital between 1 april 2008 and 30 november 2010 . the rpdr is a data warehouse that serves as a central clinic... | objectivehypoglycemia is associated with increased mortality in hospitalized patients .
we investigated the relationship between spontaneous hypoglycemia versus insulin - associated hypoglycemia and mortality in hospitalized patients.research design and methodsdata for this retrospective cohort study were obtained fr... |
the open angle glaucomas are chronic and progressive optic neuropathies , which have in common characteristic morphological changes at the optic nerve head and retinal nerve fiber layer in the absence of other ocular disease or congenital anomalies .
progressive retinal ganglion cell death and visual field loss are a... | backgroundthe purpose of this study was to investigate plasma homocysteine levels and polymorphisms in genes encoding enzymes in the metabolic pathway of homocysteine in association with primary open - angle glaucoma ( poag ) and pseudoexfoliation glaucoma ( pxfg).methodsa total of 156 glaucoma patients ( 76 with poag ... |
the 3-end single - stranded overhang of human telomeric dna is currently considered an interesting target in new anticancer therapy strategies . this is due to its ability to form , in the presence of stabilizing agents , such as monovalent cations , non - canonical g - quadruplex folds ( scheme 1a ) , which in their t... | the first crystal structure of human telomeric dna in complex with the natural alkaloid berberine , produced by different plant families and used in folk medicine for millennia , was solved by x - ray diffraction method .
the g - quadruplex unit features all - parallel strands .
the overall folding assumed by dna i... |
the genetics of coronary artery disease in alaska natives ( gocadan ) study population includes eskimos residing in the norton sound region of alaska . of this population , 1,214 family members , aged 18 years , were recruited ( october 2000april 2004 ) ( 7 ) .
. sitting blood pressure was measured , and the mean of ... | objective to explore relationships between c - reactive protein ( crp ) , subclinical infection , insulin resistance , and metabolic syndrome.research design and methods data from 1,174 eskimos , aged 18 years , from the genetics of coronary artery disease in alaska natives ( gocadan ) study were analyzed ; 40 partic... |
pancreatic cancer is the most lethal of the common human malignancies and the fourth and fifth leading cause of cancer - related death in the united states and japan , respectively [ 1 , 2 ] .
since the majority of cases of are diagnosed at the advanced or metastatic stages of disease , less than 20% of patients are ... | while the gastric involvement of pancreatic cancer is occasionally observed as the result of direct invasion , hematogenous gastric metastasis is rare . a 72-year - old japanese male presented with general fatigue , pollakiuria , and thirst . computed tomography revealed a 4.6-cm solid mass in the pancreatic tail and a... |
dementia describes a global constellation of symptoms : memory , cognition , and communication problems .
it commonly affects older people ( most often age 60 and up ) , but it is not a normal part of aging .
dementia occurs when brain cells , or neurons , are damaged and no longer network properly .
the most co... | editor s note : purpose in life ( pil ) is a research area that focuses on the interactions between mind and body and the powerful ways in which emotional , mental , social , and spiritual factors can directly affect health .
it links the belief that your life has meaning and purpose to a robust and persistently impr... |
vascular malformations ( vm ) are a general term used to describe a group of lesions formed by an anomaly of the capillary , venous , lymphatic , and arterial system
. these are structural anomalies of blood vessels without endothelial proliferation which presents at birth , commonly manifest in childhood or adolesce... | vascular malformations are one of the most common lesions of the oral cavity
. the lesion may be a congenital malformation observed in neonates or arteriovenous malformation observed in adults .
various surgical and medical managements are possible for vascular lesions which include surgical excision , laser therap... |
environmental and industrial lead exposures continue to pose major public health problems in children and in adults .
acute exposure to high concentrations of lead can result in proximal tubular damage with characteristic histologic features and manifested by glycosuria and aminoaciduria .
chronic occupational expo... | |
type 2 diabetes is one of the most prevalent chronic diseases and it is the fourth major cause of mortality worldwide ( 1 ) . the world health organization ( who ) estimates that the number of people with diabetes in range of 45 - 64 years old will be more than 140 million in developing countries and more than 30 milli... | background : type 2 diabetes is the fourth major public health problem worldwide .
royal jelly ( rj ) insulin - like activity and blood glucose modulating properties have been reported in animal and healthy volunteers.objectives:this study aimed to investigate the effect of a single dose of fresh rj as a complementar... |
a total of 100 dentate dental students of which 50 males and 50 females aged between 20 and 25 years were randomly selected as representative of the young adult group .
the selected students had no restorations in the anterior teeth and had not received orthodontic treatment .
the clinical research study was conduc... | aims : to determine various tooth form , arch form , and palatal form with gender identification between males and females of the saudi population.materials and methods : irreversible hydrocolloid impressions were made of the maxillary teeth of 100 dentate male and female subjects to obtain study casts .
a standardiz... |
the incidence of canine impaction varies across populations and has been reported to a range between 2% and 3% in the maxilla .
traditionally , orthodontists relied on clinical examination and radiographs to locate impacted teeth and decide on a treatment plan . with the availability of three - dimensional ( 3d ) ima... | aim : the aims of this study are to determine the level of agreement of orthodontists in the management of impacted maxillary canines and test this agreement against a novel three - dimensional ( 3d ) classification system ( kpg index).materials and methods : a total of 55 clinicians evaluated 18 impacted maxillary can... |
diagnosis related groups ( drgs ) are one of the most striking prospective payment systems around the world in recent years ( 12 ) . as a classification system that groups patients according to ( a ) principal diagnosis , ( b ) type of treatment , ( c ) age , ( d ) surgery , and ( e ) discharge status ( 3 ) , prospecti... | abstractbackgroundgiven limited health sources , how to make drgs ( diagnosis related groups ) more feasible is a big question in developing countries .
this study contributes to the debate on how to bridge the pay - for - service and drgs during the transitional period of payment reform.methodsfrom 2008 to 2012 , 20... |
data are drawn from the whitehall ii cohort study , established in 19851988 on 10,308 individuals ( 67% men ) , aged 3555 years .
individuals gave written consent to participate in the study , and the university college london ethics committee approved the study . since inception , sociodemographic , behavioral , an... | objectivephysical activity is critically important for successful aging , but its effect on adiposity markers at older ages is unclear as much of the evidence comes from self - reported data on physical activity .
we assessed the associations of questionnaire - assessed and accelerometer - assessed physical activity ... |
homologous recombination is an ubiquitous process important for dna repair , generation of genetic diversity , and the proper segregation of chromosomes during meiosis .
the reciprocal exchange of dna strands promoted by dna strand exchange proteins is a central step in homologous recombination ( 1 ) .
although dna... | dna strand exchange , the central step of homologous recombination , is considered to occur approximately independently of dna sequence content . however , certain prokaryotic and eukaryotic genomic loci display either an enhanced or reduced frequency of genetic exchange . here
we show that the homo sapiens dna stran... |
friedreich ataxia ( fa ) , first described in 1863 , is the most common of early - onset hereditary ataxias .
this rare autosomal recessive genetic disease is characterized clinically by progressive limb and gait ataxia , dysarthria , areflexia in the lower limbs , sensory loss , muscle weakness and extensor plantar ... | we present the case of a 50-year - old female patient with friedreich ataxia ( fa ) who was treated successfully with an intrathecal baclofen ( itb)-delivering pump for painful spasms . to our knowledge , this is the second reported case of fa where itb relieved painful and disabling spasms .
we suggest that itb shou... |
lithium is still considered a first - line therapy for both the acute and long - term treatment of bipolar disorder ( bd),1 due to its well - documented antimanic,2 antisuicidal,35 and prophylactic properties6,7 and the adjunctive treatment of major depression.8 although all potential mechanisms underlying lithium mood... | increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis , cellular plasticity , and resiliency , as well as with cell atrophy or loss in specific brain regions .
this has led most recent research to focus on the possible neuroprotective effects of medications , and particularly ... |
pulpotomy , or the surgical amputation of affected coronal pulp , is generally preferred among various endodontic therapies on primary teeth due to its easy application and its rate of success.1,2 individual factors such as age , stage of root formation , whether the tooth is to be functional or not , and periodontal c... | objectives : the aim of this study was to evaluate the clinical and radiographic success rates of pulpotomized primary molar teeth restored with a compomer material with using united states public health service ( usphs ) criteria.methods:in 173 primary molars of 156 child patients , aged within 49 years ( mean age : 6... |
the chief cause of cardiovascular disease is the formation of atherosclerotic plaque possibly due to the sustained elevation of blood cholesterol and subsequent inflammatory response in vascular region [ 1 , 2 ] .
statins such as pravastatin , lovastatin , and simvastatin are widely used in the clinic for the lowerin... | both statins and klotho have been shown to be beneficial in vascular diseases .
interleukin- ( il- ) 6 is evidenced as an indicator reflecting the stability of atherosclerotic plaque and involved in the pathogenesis of artery atherosclerosis .
however , the relationship between statin , klotho , and il-6 under an i... |
poisoning from medications can happen for a variety of reasons , including intentional overdose , inadvertently taking an extra dose , dispensing or measuring errors , and exposure through breast milk .
iron poisoning is more commonly seen in children than in adults.1 iron poisoning is primarily a clinical diagnosis ... | acute iron intoxication ( fei ) in humans has not been adequately studied .
the manifestation of fei , defined as a serum iron concentration > 300 g / dl ( 55 mol / l ) within 12 hours of ingestion , include various symptoms appearing in progressive stages .
systemic toxicity is expected with an intake of 60 mg / k... |
stroke is a neurologic disturbance caused by damage to the cerebral blood vessels and one
of the most common diseases in the adults1 .
many stroke patients have a number of serious disorders such as
hemiplegia , motor disturbance , sensory disability , language impairment , communication
disorders , emotional d... | [ purpose ] this study is to analyze bioimpedance parameters and occupational assessment
for severe stroke patients with upper extremity hemiplegia . [ subjects and methods ]
experimental subjects were 20 hemiplegic stroke patients receiving rehabilitation therapy
between november to october , 2015 .
prediction... |
in recent years , technological advances and innovative technical refinements of laparoscopic instruments have encouraged surgeons to explore the application of laparoscopic methods for benign and malignant disorders of the stomach .
nonhealing gastric ulcers have been conventionally treated by open wedge resection ,... | laparoscopy , both diagnostic and therapeutic , has been used in the management of gastric pathology because of all the benefits of a minimally invasive procedure , such as faster recovery , shorter hospital stay , fewer wound complications , and other benefits .
we report a case involving the resection of a gastric ... |
thanks
to dynamic stability , a subject displaces and controls the center of gravity ( cog ) within
the base of support in dynamic functional conditions , performing complex combined movements
such as striding forward ( forward - lunge , fl ) , going up and down a step ( step - up - over , suo ) ,
and standing ... | [ purpose ] to examine the intrasession and intersession reliability and the absolute
reliability of three functional dynamic tests forward - lunge , step - up - over and sit - to - stand
tests using computerized dynamic posturography .
[ subjects and methods ] an intra - test and
test - retest , repeated mea... |
uhl 's anomaly is characterized by the partial or complete absence of the myocardium of the right ventricle .
a review in 1993 found 84 reported cases in the literature , since the beginning of 20 century .
an unguarded tricuspid valve is a rare congenital anomaly described in only a few antemortem case reports . h... | uhl 's anomaly is characterized by absence of the myocardial layer of the right ventricle , with opposition of the endocardium and epicardium .
it is rarely associated with other congenital malformation . here , we reported the rare association of uhl 's anomaly with absent tricuspid valve in an infant . |
the introduction and expansion of pediatric antiretroviral treatment ( art ) have increased the lifespan of children with perinatal acquired hiv ( pah ) .
as more children with pah are reaching adolescence , issues surrounding the disclosure of their hiv - positive status have become an important part of pediatric hi... | to promote the appropriate implementation of procedures for health disclosure to children , it is important to understand the reasons why caregivers delay the disclosure of healthcare information to children
. this paper explored the views of caregivers on what makes disclosure to children with perinatal acquired hiv... |
the genus chryseobacterium ( family flavobacteriaceae , phylum bacteroidetes ) is a group of gram - negative , nonfermenting , catalase - positive , oxidase - positive and indole - positive aerobic bacilli .
chryseobacterium strains have been isolated from a variety of environments , including composted diseased fi... | we decipher the resistome of chryseobacterium indologenes mars15 , an emerging multidrug - resistant clinical strain , using the whole genome sequencing strategy .
the bacterium was isolated from the sputum of a hospitalized patient with cystic fibrosis in the timone hospital in marseille , france .
genome sequenci... |
although , the mechanical instrumentation is an essential step in the success of root canal therapy , the generation of the smear layer is an inevitable consequence of instrumentation regardless of the type of instruments and techniques used .
mccomb and smith were first to describe the smear layer on the surface of ... | objective : the purpose of this study was to quantify the amount of calcium ions removed from the root canal by etidronic acid ( hebp ) , biopure mtad , and smearclear using atomic absorption spectrophotometer.materials and methods : fifty ( n = 50 ) freshly extracted human mandibular premolar teeth were collected and ... |
early childhood caries ( ecc ) is a complex disease which involves maxillary primary incisors within a month after eruption and spreads rapidly to involve the other primary teeth , causing serious socio - behavioural and dental problem in infants and toddlers.- despite the major advances in the field of caries preventi... | early childhood caries ( ecc ) is a devastating form of dental decay having a multi - factorial origin .
this study was undertaken to determine the prevalence of ecc in bangalore city , south india , and also to study its associated risk factors .
random sample of 1500 children , aged between 8 - 48 months , was se... |
epilepsy is a common disease with a cumulative lifetime risk of at least 3%.1 the majority of patients with epilepsy have partial seizures , accounting for about two - thirds of cases in epidemiologic studies in developed countries.2 the burden of disease is also quite high , involving significant morbidity and mortali... | epilepsy is a common disease with significant morbidity and mortality .
approximately one - third of patients with epilepsy are refractory to available seizure medications , emphasizing the need to develop better drugs with novel mechanisms of action .
ezogabine , also known as retigabine , is a new potential adjun... |
specimen collection : ccl specimens were collected from 26 stifle joints of
21 dogs with ruptured ccl ( cclr group ) . ruptured ccl was diagnosed on physical examination
by demonstrating stifle joint instability and confirmed at the time of surgery .
normal ccl
specimens were collected from 12 young beagles ( 9... | degenerative cranial cruciate ligament ( ccl ) rupture is characterized histologically by
degenerating extracellular matrix ( ecm ) and chondroid metaplasia . here
, we describe the
progression of chondroid metaplasia and the changes in the expression of ecm components in
canine ccl rupture ( cclr ) .
ccls fr... |
arterial dissection occurring at the vertebrobasilar system often presents as subarachnoid hemorrhage ( sah ) , while dissecting aneurysm at the anterior circulation tends to manifest infarction1,2,6,7 ) . although the exact prevalence has not been reported , spontaneous dissection at the anterior cerebral artery ( aca... | simultaneous subarachnoid hemorrhage and infarction is a quite rare presentation in a patient with a spontaneous dissecting aneurysm of the anterior cerebral artery .
identifying relevant radiographic features and serial angiographic surveillance as well as mode of clinical manifestation , either hemorrhage or infarc... |
since the groundbreaking study by favaloro was published in 1968 , the use of the great saphenous vein for coronary artery bypass grafting ( cabg ) has become a standard in the surgical treatment of ischemic heart disease . in poland , the first surgery involving direct cardiac revascularization was conducted by jan mo... | a case of a 66-year - old patient 13 years after coronary artery bypass grafting ( cabg ) admitted to hospital with typical ischemic chest pain and symptoms of superior vena cava syndrome ( svcs ) is described .
non - invasive diagnostics confirmed acute coronary syndrome : non - st - elevated myocardial infarction (... |
lead extraction is associated with serious complications in 1 - 2% of cases . in a recent multicenter prospective study of 1,449 consecutive patients undergoing laser lead extraction ,
procedure - related major adverse events were seen in 20 patients ( 1.4% ) including 4 deaths ( 0.28% ) .
most complications from l... | percutaneous implantable device extraction has increased in recent years and is associated with small but significant risk .
arteriovenous fistula formation is an uncommon complication of this procedure .
we report two cases where lead extraction was complicated by an arteriovenous fistula between the left internal... |
science is a notorious example of what economists call increasing returns to scalegroups of productive people feed off each other to create something that is more than the sum of its parts .
the reverse is also true : isolated individuals will have a hard time generating momentum and are less productive .
so how c... | figure 1biopolis , singapore 's futuristic research hub.how does a country one - fourth the size of rhode island with little history in biomedical science become one of the world 's biomedical research giants ?
the answer : with a pile of money and a large dose of chutzpah .
since 2000 , singapore has dumped more t... |
with the popularity of video - assisted thoracic surgery , the requirement for one - lung ventilation ( olv ) has been increasing .
olv is used to provide a good surgical field and protect normal lungs from hemorrhage or abscess caused by affected lung .
however , olv can induce ventilation - perfusion mismatch and... | inhalation anesthetic isoflurane inhibits hypoxia pulmonary vasoconstriction ( hpv ) , while dexmedetomidine ( dex ) could reduce the dose of isoflurane inhalation and potentiate hpv , but the mechanism is unclear .
inhibition of reactive oxygen species ( ros ) production can favor hpv during one - lung ventilation (... |
travoprost is a prostaglandin ( pg ) f2 analogue which is known to lower intraocular pressure ( iop ) .
travoprost preserved with antiseptic benzalkonium chloride ( bac ) ( travatan 0.004% , alcon laboratories , inc . , fort worth , tx , usa ) or sofzia preservative system ( travatan z 0.004% , alcon laboratories , i... | backgroundthis study aimed to evaluate the effect of travoprost with sofzia preservative system for lowering the intraocular pressure ( iop ) of japanese normal tension glaucoma ( ntg ) patients.methodsin this prospective , multicenter , open - label study , japanese ntg patients with baseline iops < 20 mmhg were enrol... |
the traditional approach toward treatment of low back pain ( lbp ) fails many lbp
patients1 .
the movement - impairment
system based on kinesiopathology is an evidence - based method that defines the cause and
provides solutions to lbp .
lbp is categorized into five syndromes : lumbar - flexion ,
lumbar - e... | [ purpose ] we explored the effect of thoracic movement - mediated training ( tmmt ) on back
pain and trunk range of motion ( rom ) in a lower back pain ( lbp ) patient with lumbar
flexion rotation syndrome . [ subject ] a 55-year - old male lbp patient with lumbar flexion
rotation syndrome .
[ methods ] the su... |
mudi - chood is a peculiar dermatosis affecting the nape of the neck and upper back of young women in kerala state , south india , and was first described by sugathan and nair .
it was presumed to be due to a nonspecific follicular reaction to the wet oily hair in a hot and humid environment due to the friction betwe... | mudi - chood is a strange dermatosis affecting the nape of the neck and upper back of young women in kerala state of south india .
it was first described by us in 1972 . here
we report one more such case recently seen by us . |
loco - regional recurrence and/or disease progression is the main pattern of failure as well the most common cause of death in head & neck ( h&n ) cancer [ 1 , 2 , 3 ] .
the incidence of recurrence after radical treatment may be as high as 30 - 50% [ 4 , 5 ] .
however , h&n cancers can be cured even if a close coop... | purposeaim of the cobra ( consortium for brachytherapy data analysis ) project is to create a multicenter group ( consortium ) and a web - based system for standardized data collection.material and methodsgec - estro ( groupe europen de curiethrapie
european society for radiotherapy & oncology ) head and neck ( h&n )... |
osteogenesis imperfecta ( oi ) , also known as the brittle bone disease , is a heritable connective tissue disorder , characterized by bone fragility due to low bone mass , with an increased propensity to fractures and bone deformity .
it is a rare disorder with an incidence of up to 1/30,000 and a prevalence of 6 ... | osteogenesis imperfecta ( oi ) is a rare inherited disorder with a broad spectrum of clinical and genetic variability .
the genetic diversity involves , in the majority of the cases , mutations in one of the genes that encodes the type 1 collagen protein ( col1 a1 and col1 a2 ) , but it is not a requirement for the d... |
dna double - strand break ( dsb ) is a type of dna damage in which two complementary strands of the double helix of dna are damaged simultaneously , in locations close to each other .
dsb is the most dangerous type of dna damage , because it is believed that a single unrepaired dsb is sufficient for the induction of ... | double - strand breaks ( dsbs ) are the most deleterious dna lesions , which , if left unrepaired , may have severe consequences for cell survival , as they lead to chromosome aberrations , genomic instability , or cell death .
various physical , chemical , and biological factors are involved in dsb induction .
c... |
the subchronic inhalation toxicology of ethylene glycol monoethyl ether ( egee ) was evaluated in rats and rabbits using a 13-week exposure regimen .
groups of 20 rabbits ( 10 m , 10 f ) and 30 rats ( 15 m , 15 f ) were exposed to a vapor of 25 ppm , 100 ppm , or 400 ppm , 6 hr / day , 5 days / week .
the control g... | |
the online version of this article ( doi:10.1007/s13555 - 015 - 0083 - 4 ) contains supplementary material , which is available to authorized users .
pruritus is a prominent symptom of many skin diseases and is also frequently present in hematological malignancies such as hodgkin disease and occasionally in chronic l... | introductionpruritus without visible dermatoses may be the first manifestation of hematological malignancies such as hodgkin disease , chronic lymphocytic leukemia and mycosis fungoides ( mf ) and may precede the definitive diagnosis by weeks to years.case reportwe present a case of
invisible mf associated with chron... |
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