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stem cells derived from adult human tissues are of great scientific interest to provide potential individual cell - based therapy without ethical and immunological problems associated with human embryonic stem cells . testicular tissue retrieved in the assisted reproduction programme might be an important source of s...
we describe the potential stemness of a small amount of frozen - thawed testicular tissue without sperm obtained by biopsy from six patients undergoing assisted reproductive treatment . the patients were diagnosed with sertoli cell - only syndrome alone or combined with maturation arrest . trying to provide the natur...
chagas disease , or american trypanosomiasis , is caused by the protozoan parasite trypanosoma cruzi . chagas disease is primarily a vector disease endemic in 21 latin american countries , where it has a strong economic impact because it primarily affects economically active people . approximately 10 million people...
chagas disease , or american trypanosomiasis , which is caused by the protozoan parasite trypanosoma cruzi , is primarily a vector disease endemic in 21 latin american countries , including mexico . although many vector control programs have been implemented , t. cruzi has not been eradicated . the development of a...
ghrelin is a 28-amino acid motilin - related peptide hormone mainly secreted by the x / a - like enteroendocrine cells of the oxyntic ( parietal ) mucosa of the gastric fundus . it is the endogenous ligand for the growth - hormone secretagogue receptor ( ghs - r ) 1a , recently discovered by two independent research ...
this review evaluated published data regarding the effects of ghrelin on gi motility using the pubmed database for english articles from 1999 to september 2009 . our strategy was to combine all available information from previous literature , in order to provide a complete structured review on the prokinetic properti...
over the past decade the incidence of hepatocellular carcinoma ( hcc ) has doubled . in the asia - pacific region , 500 000 new cases occurred every year , with an estimated 360 000 deaths in far east countries only . china alone had more than 60% of the total hcc cases , most of which were due to chronic hepatitis...
backgroundalthough some recent reports have shown that the expression level of mir-193a varied in different cancers , its role in hepatocellular carcinoma ( hcc ) remains unidentified . the aim of the current study was to validate the relationship between mir-193a-3p and clinicopathological characteristics in hcc pat...
mice were handled according to guidelines established by the northwestern university animal care and use committee , the national institutes of health and the society for neuroscience . midbrain slices were visualized using infrared - differential interference contrast ( ir - dic ) video microscopy system ( for patch...
parkinson 's disease ( pd ) is a pervasive , aging - related neurodegenerative disease whose cardinal motor symptoms reflect the loss of a small group of neurons dopaminergic neurons in the substantia nigra pars compacta ( snc)1 . mitochondrial oxidant stress is widely viewed as responsible for this loss2 , but why t...
management of patient with prolactinoma during pregnancy is a big challenge to the obstetrician as prolactin levels elevation in pregnancy is a normal phenomenon and there are possibilities that one can misdiagnose this problem . although the drug cabergoline has almost completely replaced bromocriptine in nonpregnan...
management of prolactinoma in pregnancy is a big challenge for the treating obstetrician as prolactin levels are normally raised in pregnancy and this creates a possibility of missing the diagnosis of prolactinoma . women with micro adenomas and intrasellar macro adenomas do not require serial magnetic resonance imag...
the discovery of mirror neurons that fire when an animal performs a goal - directed action or sees others perform the action gave rise to both monkey and human studies on the neural correlates of imitation ( rizzolatti and craighero , 2004 ; iacoboni and dapretto , 2006 ) . while the circuitry for motor imitation is de...
the mirror system hypothesis and investigations of birdsong are reviewed in relation to the significance for the development of human symbolic and language capacity , in terms of three fundamental forms of cognitive reference : iconic , indexical , and symbolic . mirror systems are initially iconic but can progress t...
obesity is characterized by an excessive accumulation of fat in the adipose tissue ( 1 , 2 ) . a product of the obese ( ob ) gene , called leptin , is released primarily from adipocytes and plays a key role in regulating body weight ( 3 ) . in most obese subjects , leptin fails to perform its physiological function...
contextunder normal physiological conditions , leptin regulates body weight by creating a balance between food intake and energy expenditure . however , in obesity , serum leptin levels increase and become defective to retain energy balance.evidence acquisitionelevated serum leptin levels are regarded as an establish...
the health risk assessment of environmental selenium , concerning both abnormally low and high intakes , and the related regulatory guidelines are generally based on old evidence , since they have generally been unable to take into consideration the most recent epidemiologic and biochemical evidence , and particularly...
new data have been accumulated in the scientific literature in recent years which allow a more adequate risk assessment of selenium with reference to human health . this new evidence comes from environmental studies , carried out in populations characterized by abnormally high or low selenium intakes , and from high ...
the occurrence of end - stage renal disease ( esrd ) and dialysis access placement in the united states continues to increase . due to the superior long - term patency , lower complications , and decreased mortality rates , arteriovenous fistulas ( avfs ) are the access of choice and represent 41.3% of the total hemodi...
the rate of arteriovenous fistula ( avf ) placement continues to rise and avf failure is a major complication . the main cause of avf failure is stenosis leading to thrombosis . although the detection of early stenosis with preemptive correction prior to thrombosis seems to be a plausible option to prevent access f...
essential thrombocythemia ( et ) is one of the bcr - abl negative myeloproliferative neoplasms . diagnosis is made when 1 ) platelet count is higher than 450 10/ ; 2 ) patients have the jak2 v617f mutation or another clonal mutation such as in the gene encoding the thrombopoietin receptor ( mpl ) ; 3 ) bone marrow r...
thrombosis risk in essential thrombocythemia ( et ) patients can be assessed using different prognostic systems . conventional risk factors include age more than 60 years and history of previous thrombosis . in addition , other factors such as jak2 v617f mutations , cardiovascular risk factors , leukocytosis more t...
traumatic brain injury ( tbi ) is a global public health issue with few treatment options available ( chauhan , 2014 ) . with approximately 10 million people affected by tbi annually , it is a major cause of death and disability worldwide , and the world health organization projects that it will surpass the mortality...
traumatic brain injury ( tbi ) is a major health problem worldwide . following primary mechanical insults , a cascade of secondary injuries often leads to further neural tissue loss . thus far there is no cure to rescue the damaged neural tissue . current therapeutic strategies primarily target the secondary injuri...
internally , mutations and shifting genetic backgrounds change the genetic context in which genes are expressed . externally , changing environmental conditions alter the global context within which molecular systems operate and to which they must respond . understanding how biological systems evolve robust function ...
organisms face a constantly shifting landscape of environmental conditions and internal physiological states . how gene regulation and cellular functions are maintained across genetic and environmental variation is therefore a fundamental question in biology . here , we analyze the saccharomyces cerevisiae genetic ...
diabetes mellitus is a syndrome of disordered metabolism with inappropriate hyperglycemia due to either an absolute or relative deficiency of insulin secretion or a reduction in the biologic effectiveness of insulin ( or both ) and is associated with disturbances in the metabolism of carbohydrates , protein , and lipid...
background : to study cytological alterations in the exfoliated buccal cells of diabetic patients . to analyze the cytomorphometric findings in the smears of uncontrolled and controlled diabetic patients and compare it with that of normal healthy controls . to establish a correlation between cytomorphometric changes an...
sharp objects such as a toothpick sometimes fail to pass and may cause a perforation . the possible complications reported in the literature include obstruction , perforation , haemorrhage , fistula formation and sepsis . toothpick injury to the gut is a rare condition for which a low intellectual quotient and extr...
we present the case of a 23-year - old man who consulted in the emergency department 6 days after ingesting a wooden toothpick with features of a localized peritonitis in the left upper quadrant of the abdomen . surgical exploration revealed a perforation of the splenic flexure of the colon by the toothpick during it...
the problems get compounded when there is the presence of infection around the hip implants.1 deep infection after a hip fracture operation impairs functional outcome and increases mortality by 10.4%.2 eradication of infection becomes necessary for any definitive procedure to be performed on the hip . the patients ar...
background : failed infected internal fixation produces significant pain and functional disability . in infected internal fixation of hip fractures with partial or complete head destruction , total hip arthroplasty ( tha ) can be technically challenging ; however , it restores hip biomechanics . the present study is ...
previous randomized clinical trials have established the efficacy of reducing intraocular pressure ( iop ) in patients with glaucoma,15 confirming that iop management plays a central role in preventing further progression of glaucomatous optic neuropathy.68 although the goldmann applanation tonometer ( gat ) ( haag str...
backgroundto compare intraocular pressure ( iop ) readings using the icare rebound tonometer ( rbt ) versus the goldmann applanation tonometer ( gat ) in late elderly ( aged 75 years or older ) subjects with or without glaucoma , and to evaluate the influence of central corneal thickness ( cct ) on iop readings.methods...
congenital cholesteatomas of the temporal bone are epidermoid cysts of embryologic origin that result in progressive desquamation and trapping of squamous epithelium behind an intact tympanic membrane.1 they are benign , slowly progressive lesions that can be found in various areas of the temporal bone.1 we report a ca...
introduction congenital cholesteatomas of the temporal bone are epidermoid cysts of embryologic origin that result in progressive desquamation and trapping of squamous epithelium behind an intact tympanic membrane . they are benign , slowly progressive lesions that can be found in various areas of the temporal bone ...
a timely and effective restoration of blood flow , i.e. reperfusion , is essential for ischemic limb recovery , but reperfusion can also aggravate the initial ischemia - induced injury , which is known as ischemia / reperfusion ( ir ) injury ( 1 ) . ir injury not only exacerbates the damage of the local ischemic tiss...
objective(s):neutrophils play an important role in ischemia / reperfusion ( ir ) induced skeletal muscle injury . microtubules are required for neutrophil activation in response to various stimuli . this study aimed to investigate the effects of colchicine , a microtubule - disrupting agent , on skeletal muscle ir ...
in april 2006 , a 76-year - old man was admitted to the emergency department of pontchaillou university hospital , rennes , france , with acute onset of fever , lumbar pain , and dyspnea . ( 90.6% neutrophils ) , c - reactive protein 216 mg / l ( normal value < 5 mg / l ) , and arterial oxygen partial pressure 67 mm ...
coxsackievirus a-16 ( cva-16 ) is the agent of hand , foot , and mouth disease in children . we report a case of fatal pneumonitis in an adult due to a cva-16 strain with a low ( 78.6% ) rate of sequence homology with the reference strain . a modified , more virulent , strain of cva-16 could be emerging .
periodontitis , a periodontal disease , results from interaction between the immune system and oral bacteria that may promote oxidative stress and initiate an inflammatory cascade inducing the destruction of the oral structure . the immunomicrobial pathogenesis of periodontitis involves chronic inflammation , which a...
abstractperiodontitis is a systemic and chronic inflammatory disease associated with multiple physical conditions . distress and depression are other problems affecting the progression of periodontitis . however , the causal relationship between depression and periodontitis has not been adequately investigated . ...
various types of cages are currently widely used for the treatment of degenerative cervical disc disease . however , controversy remains regarding a high incidence of complications , such as cage subsidence , kyphotic deformity , and pseudarthrosis [ 13 ] . anterior cervical discectomy and fusion ( acdf ) with plat...
a total of 25 consecutive patients suffering from degenerative cervical disc disease who underwent three - level anterior cervical discectomy and fusion ( acdf ) including polyetheretherketone ( peek ) cages packed with allograft were followed up for at least two years . the fusion rate reached 72% ( 18/25 ) , and as...
occupational exposure to hair dyes has been associated with an increased risk of bladder cancer [ 1 , 2 ] . the international agency for research on cancer ( iarc ) concludes that hairdressers and barbers are probably at greater risk of bladder cancer because of their exposure to hair dyes . this has raised conce...
backgroundseveral studies have suggested an increased risk of bladder cancer among hairdressers , who are occupationally exposed to hair dyes . there has also been concern about a possible increased risk of bladder cancer among users of hair dyes . however , the association between personal hair dye use and bladder c...
the first - generation fluoroquinolones ( e.g. , ciprofloxacin , ofloxacin , norfloxacin ) are primarily active against gram - negative and some gram - positive organisms . the second - generation fluoroquinolone , levofloxacin , is the l - isomer of ofloxacin and demonstrates somewhat improved gram - positive activi...
previous experience with antimicrobial resistance has emphasized the importance of appropriate stewardship of these pharmacotherapeutic agents . the introduction of fluoroquinolones provided potent new drugs directed primarily against gram - negative pathogens , while the newer members of this class demonstrate more ...
the first outbreak we investigated occurred in a facility that provided housing and harm - reduction services to a predominantly hiv - positive , homeless , and drug - using population ( site a ) . the first tb case - patient identified was a 53-year - old hiv - positive man residing there , in whom pulmonary tb was ...
contacts of persons infected with multidrug - resistant tuberculosis ( mdr tb ) have few prophylaxis options . of 50 contacts of hiv- and mdr tb positive persons who were treated with moxifloxacin , 30 completed treatment and 3 discontinued treatment because of gastrointestinal symptoms . moxifloxacin was general...
age - related macular degeneration ( amd ) is the most common cause of severe vision loss in patients over the age of 60 . there are two major forms of amd , a non - neovascular or atrophic and a neovascular form . the neovascular form ( nvamd ) is characterized by the formation of subretinal choroidal neovasculari...
neovascular age - related macular degeneration ( nvamd ) is characterized by choroidal blood vessels growing into the subretinal space , leading to retinal pigment epithelial ( rpe ) cell degeneration and vision loss . vessel growth results from an imbalance of pro - angiogenic ( e.g. , vascular endothelial growth fa...
the differences between definitions of health can be understood as caused by differences in ontological assumptions about the nature of reality and by the view of the nature of human beings ( tengland , 2007 ) . the biomedical view of reality and of health is built on the positivistic ideal of science , which prior...
health , well - being , quality of life , and lifestyle are central concepts within health science , although generally accepted definitions are still lacking . lifestyle can either be seen as an independent variable and the cause of unhealthy behaviour or as a dependent variable , which is affected by conditions in ...
dengue ranks as the most important mosquito borne viral disease in the world endemic in over 100 countries in the world affecting 40% of the world population . according to who estimates , 50100 million cases of dengue infections with 500000 cases of dengue hemorrhagic fever ( dhf ) and 22,000 deaths occur annually i...
background : the aim of this study was to assess community knowledge and behavioral impact of the social mobilization and communication strategy applied in a dengue high - risk area in sri lanka.methods:a group of adults visiting selected primary care facilities in colombo district were interviewed to collect socio - d...
avian influenza viruses ( aivs ) are member of the family orthomyxoviridae , genus influenzavirus a . influenza a viruses are classified according to the antigenic properties of their hemagglutinin ( ha ) and neuraminidase ( na ) surface glycoproteins . till date , 16 ha subtypes and 9 na subtypes have been recognize...
h6 subtype influenza viruses are commonly isolated from wild aquatic birds . however , limited information is available regarding h6 influenza virus isolated from chickens . we compared the viral genome segment between a / chicken / hong kong / w312/97 ( h6n1 ) , which was able to grow in chicken trachea , and a / duck...
tanzania is located on the eastern coast of africa and consists of the tanzanian mainland and the island of zanzibar . countries neighboring tanzania include , counterclockwise from the north , kenya , uganda , rwanda , burundi , the democratic republic of congo ( drc ) , zambia , malawi , and mozambique . in kenya a...
peste des petits ruminants virus ( pprv ) causes the acute , highly contagious disease peste des petits ruminants ( ppr ) that affects small domestic and wild ruminants . ppr is of importance in the small livestock - keeping industry in tanzania , especially in rural areas as it is an important source of livelihood ....
sebaceous hyperplasia ( sh ) is a benign proliferation of the sebaceous glands , which in most cases is idiopathic and affects elderly patients . sh results from intrinsic , genetically determined ( chronological ) aging and extrinsic environmental photoaging . moreover , this affection can arise in the setting of ...
many cutaneous complications have been described in patients treated with cyclosporin . alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent . however , the occurrence of sebaceous hyperplasia is exceptional . these lesions seem to be specific to cyclosporin rather than secondary...
the basque department of health released in 2010 the strategy for tackling the challenge of chronicity in the basque country . one of its five priority policies is contributing to the continuity of care for chronic patients . a key strategic project is the development of new integration initiatives and pilots pro...
contextthe basque department of health released in 2010 the strategy for tackling the challenge of chronicity in the basque country . one of its five priority policies is contributing to the continuity of care for chronic patients . a key strategic project is the development of new integration initiatives and pil...
chronic obstructive pulmonary disease ( copd ) is one of the most frequent causes of mortality in the world . copd is usually associated with a number of secondary impairments such as cardiac , metabolic , peripheral muscle , and psychosocial dysfunction . a major problem among these co - morbidities is skeletal musc...
background and objectivesskeletal muscle dysfunction is a major problem among the co - morbidities associated with chronic obstructive pulmonary disease ( copd ) . however , muscle weakness and increased fatigability are not the only limitations of skeletal muscle function . motor respiratory coordination ( mrc ) ma...
trigeminal neuralgia ( tn ) , a neuropathic disorder of one or both of the trigeminal nerves , occurs most often in people over age 50 , and affects women more often than men . tn can be either primary trigeminal neuralgia or secondary trigeminal neuralgia , which is associated with some other diseases , with symptom...
trigeminal neuralgia ( tn ) , a neuropathic disorder of one or both of the trigeminal nerves , occurs most often in people over age 50 . extreme , sporadic , sudden burning or shock - like face pain in common activities greatly lowers quality of life . the precise cause of primary tn remains unknown , but it may be...
the patient is a 54-year - old male who was referred to our clinic due to a large abdominal mass . he complained of early satiety , anorexia , weakness and weight loss during the 6 months before admission . nine years ago , he had noticed the presence of a 4- to 5-cm right renal mass . he was advised to have surg...
the clinical diagnosis of renal cell carcinoma ( rcc ) is radiographic . effective imaging of the kidneys can be achieved by ultrasound , ct or mri [ chawla et al . : j urol 2006;175:425431 ] . solid lesions detected by ultrasound and those showing enhancement on cross - sectional imaging are considered malignant...
in recent years , advances in the training of military and aviation personnel have been successfully applied to the training of health care providers in efforts to enhance patient safety . these include simulation to teach judgment and technical skills and a systems perspective in the analysis of errors and near miss...
many surgeons continue to actively pursue surgical approaches that are less invasive for their patients . this pursuit requires the surgeon to adapt to new instruments , techniques , technologies , knowledge bases , visual perspectives , and motor skills , among other changes . the premise of this paper is that sur...
hormonal changes at the moment of parturition may constitute an important regulatory mechanism for myometrial contraction . in some species ( e.g. , sheep ) , sudden changes in circulating cortisol , oestrogen , and progesterone appear to be important factors for the onset of labour , whereas in humans , these signs ...
objective . to assess the concentration of progesterone ( prs ) and oestrogen ( ors ) receptors of myometrium of full - term pregnant women in the myometrium of lower segment of the uterus in relationship with presence or absence of labour . methods . this was a cross - sectional prospective study with 21 pregnant ...
bacterial strains and media - s. sonnei strains , named ss9 and ss12 , were isolated from children with acute diarrhoea who presented for treatment at children 's hospital joo paulo ii / hospital foundation of the state of minas gerais , belo horizonte , brazil . the isolates were selected as producer and ind...
bacteriocins are antibacterial , proteinaceous substances that mediate microbial dynamics . bacteriocin production is a highly disseminated property among all major lineages of bacteria , including shigella . in this paper , we addressed the purification and characterisation of a bacteriocin produced by a s...
cardiovascular prevention and rehabilitation improves functional and clinical status , health - related quality of life , and prognosis in patients with coronary heart disease ( chd ) recovering from acute events and invasive interventions.1 for more than a decade , cardiac rehabilitation ( cr ) has been recommended fo...
aim of databasethe danish cardiac rehabilitation database ( dhrd ) aims to improve the quality of cardiac rehabilitation ( cr ) to the benefit of patients with coronary heart disease ( chd).study populationhospitalized patients with chd with stenosis on coronary angiography treated with percutaneous coronary interventi...
from april to september 2004 , using cluster random sampling method , 3600 subjects were enrolled based on postal code divisions of 17 districts in shiraz , southern iran . each subject was invited to refer to mottahari clinic of gastroenterohepatology research center affiliated to shiraz university of medical scienc...
background : the symptoms of irritable bowel syndrome ( ibs ) are common in the general population . the aim of this population - based study was to determine the prevalence of ibs and describe the associated factors including demographic , life style and health - seeking behaviors in shiraz city , southern iran.meth...
poly ( methyl methacrylate ) resins have dominated the denture base market for over 50 years . it is known that denture bases may act as a reservoir of microorganisms and contribute to oral diseases , such as denture stomatitis , a chronic inflammatory response in the oral mucosa , in complete denture wearers ....
polymethyl methacrylate ( pmma ) resins have commonly been used as a denture base material . however , denture bases may act as a reservoir for microorganisms and contribute to oral diseases in denture wearers . it is hypothesized that the 2-tertbutylaminoethyl methacrylate ( tbaema ) incorporated to acrylic re...
mitochondria contain their own genome and , as is the case for any other genome , must maintain tight control over the expression of their encoded gene products . mitochondrial genes typically encode either components of the respiratory chain for atp synthesis or the mitochondrial translation machinery . regulating t...
pentatricopeptide repeat ( ppr ) proteins are rna binding proteins with functions in organelle rna metabolism . they are found in all eukaryotes but have been most extensively studied in plants . we report on the identification of 12 ppr - encoding genes in the genome of the protist dictyostelium discoideum , with ...
smoking is an important risk factor for oral diseases such as oral cancer , periodontal disease , cleft lip , cleft palate , alveolar bone loss , and black hairy tongue.1 - 3 the evidence showing that the use of tobacco is the major risk factor for oral cancer and potentially malignant lesions of the mouth is obvious.4...
tobacco smoking is one of the most important risk factors for the development of oral mucosal lesions such as leukoplakia and hairy tongue . controversy exists in the literature , however , about the prevalence of oral lesions in smokers . the aim of this study was to evaluate oral lesions in male smokers compared ...
fibromyalgia syndrome ( fms ) , which is characterized by widespread pain and fatigue , is a disease that affects the connective tissues and locomotor system1,2,3 . patients with fms also suffer from weakness , fatigue , lack of energy , sleep disturbances , waking up tired in the morning ( non - restorative slee...
[ purpose ] there are various treatment modalities for fibromyalgia syndrome ( fms ) , which is characterized by widespread pain and fatigue . the aim of this study was to investigate the effects of aquatic , aerobic and isometric strength - stretching exercises on the physical and psychological parameters of pat...
this study is approved by institutional review board of hanyang university guri hispital ( no . 2012 - 003 ) on human subjects research and ethics committees . for this retrospective cohort study , we initially enrolled 339 patients who underwent less than two - level posterior instrumented fusions for lumbar spina...
backgroundthe aim of this study is to evaluate the effect of depression , anxiety , and optimism on postoperative satisfaction and clinical outcomes in patients who underwent less than two - level posterior instrumented fusions for lumbar spinal stenosis and degenerative spondylolisthesis.methodspreoperative psychologi...
" medical studies prepare [ students ] well for the examinations , but poorly for the job as a doctor " concluded a poll of the centre for the development of higher education ( zentrums fr hochschulentwicklung ) among approximately 300 medical students in germany [ http://www.che.de/downloads/medizinstudium20_auswert...
primary care is in a unique position to teach the broad spectrum of differential diagnoses . we developed and piloted a new elective seminar differential diagnosis in primary care. with the help of simulation patients , training models , interactive small group work , and short lectures we addressed common complaint...
stainless steel crowns have long been used as durable restorations for the reconstruction of primary teeth that have undergone pulpotomy or pulpectomy and those with developmental defects or extensive , multi - surface carious lesions . these crowns can maintain the health of the surrounding tissues and prevent devel...
objectives : it is not clear what type of pre - crimped crown is more successful in achieving greater marginal adaptation following re - crimping . this study aimed to assess the changes in the circumference of 3 m espe and mib pre - crimped stainless steel crowns ( sscs ) for the primary maxillary and mandibular fir...
type 2 diabetes mellitus ( t2 dm ) and depression are major public health issues . worldwide , more than 365 million people are estimated to have t2 dm , and almost 300 million people have major depression . both these disorders are projected to be among the five leading causes of disease burden by 2030 . depress...
background : depression is common among diabetes , and is associated with poor outcomes . however , the data on this important relationship are limited from india.objective:the aim was to estimate the prevalence of depression in patients with diabetes and to determine the association of depression with age , sex , and ...
achromobacter xylosoxidans ( ax ) is a non - fermentative aerobic gram - negative bacillus . the emergency brain computer tomography ( ct ) scan did not reveal any anomaly . in his medical history , there was an auditory injury due to a cranial trauma incurred in a skiing accident 60 years earlier . cytobiochemical...
summarybackgroundachromobacter xylosoxidans ( ax ) is a non - fermentative aerobic gram - negative bacillus . it is an opportunistic pathogen and the causative agent of various infections . we report an original case of late posttraumatic meningitis due to ax denitrificans.case reportan 83-year - old man was hospit...
neisseria gonorrhoeae ( ngo ) or gonococcus , a gram - negative diplococcus , is the etiological agent of the sexually transmitted bacterial infection ( sti ) gonorrhoea . gonorrhea is the second most frequent sti worldwide , where the total number of new cases of gonorrhea in adults was estimated to be 106.1 million...
neisseria gonorrhoeae ( ngo ) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses . recent findings have reported that ngo reduces the il-1 secretion of infected human monocyte - derived macrophages ( mdm ) . here , we investigate the role of adenosine triphosphate ( ...
staphylococcus aureus and its resistant form , methicillin - resistant s. aureus ( mrsa ) , rank top among the clinically most relevant nosocomial pathogens , leading to increased morbidity , mortality , length of hospital stay and costs [ 14 ] . colonized healthcare workers ( hcws ) are capable of developing clinica...
summaryhealthcare workers ( hcws ) may be a reservoir for staphylococcus aureus transmission to patients . we examined whether hcw status is associated with s. aureus nasal carriage and population structure ( spa types ) in 1302 women ( 334 hcws ) and 977 men ( 71 hcws ) aged 3069 years participating in the populatio...
adult onset asthma with periorbital granuloma ( aapox ) syndrome was first described in 1993 by jakobiec et al and is considered to be a periorbital disease with a specific granulomatous inflammation . palpebral biopsy shows multinucleated histiocytes with a foamy cytoplasm , referred to as touton giant cells . in ...
abstractadult onset asthma and periocular xanthogranuloma ( aapox ) is a rare non - langerhans histiocytosis characterized histopathologically by a periocular infiltration of foamy histiocytes and touton giant cells . benign hyperplasia with plasma cell infiltration is classically described in eyelids or lymph nodes ...
breast cancer imaging has improved over the last decade with higher and more uniform quality standards for mammography as well as through the increasing use of sonography and magnetic resonance imaging as the adjunct tools . mammography is still the only screening tool to detect breast cancer for asymptomatic women ....
flat panel detector - based cone beam breast ct ( cbbct ) can provide 3d image of the scanned breast with 3d isotropic spatial resolution , overcoming the disadvantage of the structure superimposition associated with x - ray projection mammography . it is very difficult for mammography to detect a small carcinoma ( a...
anopheles gambiae is the main vector of the human malaria parasite , plasmodium falciparum , in africa . the number of cases of malaria , and their severity , have increased , leading to an increase in the social and economic burden of this disease . the development of drug resistance in parasites and insecticide resis...
backgroundanopheles gambiae is the main vector of plasmodium falciparum in africa . the mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted . despite the central role of the mosquito midgut in the host / parasite interaction , little is known about its protein c...
continuity of care is the process by which patients experience linked care from one health care setting to another . it has been defined as having three components : ( 1 ) physician continuity , ( 2 ) information continuity , and ( 3 ) management continuity . 1 previous studies have consistently demonstrated defici...
backgrounddeficits in the transfer of information between inpatient and outpatient physicians are common and pose a patient safety risk . this is particularly the case for vulnerable populations such as patients with end - stage renal disease requiring dialysis . these patients have unique and complex health care n...
breast cancer is the most common cancer in women worldwide , affecting approximately 240,000 cases in north america . lung , bone , and brain are common sites of metastasis in patients with breast cancer . mediastinal lymph node ( ln ) metastases , however , occur in only 2% of patients with breast cancer during su...
purposea newly isolated mediastinal lymph node ( ln ) or a small pulmonary nodule , which appears during breast cancer surveillance , may pose a diagnostic dilemma with regard to malignancy . we conducted this study to determine which clinical factors were useful for the differentiation of malignant lesions from beni...
we denote by [ a , b ] = ab ba the simple commutator of the elements a , b r and by [ a , b]k = [ [ a , b]k1 , b ] , for k > 1 , the kth commutator of a , b. throught this paper we will use the following notation : u will be the ( two - sided ) utumi quotient ring of a ring r ( sometimes , as in , u is called the sy...
let r be a prime ring of characteristic different from 2 , with extended centroid c , u its two - sided utumi quotient ring , f a nonzero generalized derivation of r , f(x1 , , xn ) a noncentral multilinear polynomial over c in n noncommuting variables , and a , b r such that a[f(f(r1 , , rn ) ) , f(r1 , , rn)]b =...
hypothyroidism can affect all the organ systems of the body and can have varied manifestations . it can lead to hyperprolactinemia mainly because of pituitary thyrotroph hyperplasia . in hashimoto 's thyroiditis , the incidence of hyperprolactinemia has been reported to be 11.1% in subclinical and 42.4% in overt hy...
pituitary thyrotroph hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism . premenopausal females with this disorder can present with features of hypothyroidism , menstrual disturbances , galactorrhea , and visual field defects because of enlarged pituitary . here ...
nanotechnology has been used in various fields of science and technology , including physics , electronics , medicine , and chemistry , among other areas of interest to the scientific community . interest in nanotechnology is growing and continues to change the way we perceive and execute things , has a pronounced ef...
advances in nanotechnology are producing an accelerated proliferation of new nanomaterial composites that are likely to become an important source of engineered health - related products . nanoparticles with antifungal effects are of great interest in the formulation of microbicidal materials . fungi are found as i...
oral hygiene can vary in children within the same age group and depends on many factors , one of the most important of which are the hygiene habits of adults and the steps they take to pass on these habits to those in their care . being aware of the need to take care of oral health is reflected in the frequency with ...
backround : the study is focused on increased risk of dental plaque accumulation among the children undergoing orthodontic treatment in consideration of individual hygiene and dietary habits.materials and methods : the study was conducted among 91 children aged 7 - 14 including 47 girls and 44 boys . the main objecti...
granulomas in the gallbladder wall are exceedingly rare . a case of granulomatous cholecystitis in the context of tuberculosis we report a case of gallbladder epithelioid and giant cell granulomas occurring in the course of treated thoraco - abdominal sarcoidosis and revealed by lithiasic cholecystitis . the patien...
gallbladder granulomas are exceedingly rare , reported in association with tuberculosis or sarcoidosis . here we report a case of gallbladder granulomatous cholecystitis occurring in the context of sarcoidosis . a 70-years old man presented with abdominal pain , nausea and vomiting . the medical history revealed sa...
it has excellent tissue penetration in the skin and soft tissue infections and is a well - tolerated drug . cutaneous adverse drug reactions ( adrs ) are seen in about 12% of treated patients . urticaria angioedema , maculopapular exanthem , and photosensitivity are the most frequently documented cutaneous adverse ...
cutaneous adverse drug reactions ( adrs ) are seen in about 12% cases . fixed drug reaction ( fdr ) is responsible for about 10% of all adrs . it is a delayed type of hypersensitivity reaction that occurs as lesions recurs at the same skin site due to repeated intake of an offending drug . the most common drugs c...
spinal cord injury ( sci ) is one of the most serious injuries of the central nervous system , resulting in severe disabilities that affect independent functional activities in the individual s personal and social life1 , 2 . most individuals with sci generally rely on assistive technology ( at ) as the primary...
[ purpose ] the study purpose was to investigate the test - retest reliability of the quebec user evaluation of satisfaction with assistive technology 2.0-korean version ( quest - k ) for individuals with traumatic spinal cord injury . [ subjects and methods ] seventy participants with spinal cord injury were e...
being at risk of undernutrition or being undernourished is a frequent problem among older patients,13 but to a less extent among older home - dwelling people.46 however , older home - dwelling people receiving home health care have been found to be at high risk for developing undernutrition.7 therefore , to use a nutri...
backgroundnutritional screening instruments need to be evaluated in terms of reliability and validity and being able to demonstrate sensitivity and specificity for use in clinical practice and research . the aims of this study were to test the reliability and validity of the norwegian version of the nutritional form ...
maternal thyroid function changes during pregnancy as a result of physiological alterations in some factors such as thyrotrophic effect of human chorionic gonadotropin ( hcg ) , increased iodine clearance in the kidneys , and increased thyroid hormone - binding globulin ( tbg ) concentration . thyroid dysfunction , i...
backgroundthe study aimed to investigate the clinical value of velocity vector imaging ( vvi ) in assessing heart function in fetuses of pregnant women with thyroid dysfunction . the inter - observer and intra - observer variability was assessed for all vvi parameters observed.material/methodsthe participants were en...
the antifolate combination sulfadoxine /pyrimethamine ( sp ) is currently the first line treatment for uncomplicated falciparum malaria in several african countries . pyrimethamine ( pm ) and sulfadoxine ( sd ) are inhibitors of dihydrofolate reductase ( dhfr ) and dihydropteroate synthase ( dhps ) respectively . t...
the selection of point mutation at codon 164 ( from isoleucine to leucine ) of the dihydrofolate reductase ( dhfr ) enzyme in plasmodium falciparum is associated with high sulfadoxine /pyrimethamine ( sp ) resistance . using the yeast expression system that allows the detection of dhfr allele present at low level , t...
a segmental testicular infarction ( sti ) is a rare cause of acute scrotum . the etiologic mechanism is largely considered idiopathic , but cases have been associated with hypercoagulability disorders , vasculitis , torsion , trauma , infection , and iatrogenic vascular injury ( 1 , 2 ) . a sti usually presents with ...
segmental testicular infarction ( sti ) is a rare cause of acute scrotum . the spectrum of findings on gray - scale and color doppler ultrasonography differ depending on the time between the onset of testicular pain and the ultrasonography examination . we are not aware of the usefulness of shear - wave elastograph...
the diabetes autoimmunity study in the young ( daisy ) has followed two cohorts of young children at increased risk of diabetes ( n = 2,542 ) , including relatives and general population children screened for susceptibility hla - dr / dq genotypes . autoantibodies to gad , ia-2 , and insulin ( iaa ) were measured in ...
objectivewe evaluated predictors of progression to diabetes in children with high - risk hla genotypes and persistent islet autoantibodies.research design and methodsthe diabetes autoimmunity study in the young ( daisy ) followed 2,542 children with autoantibodies measured to gad , ia-2 , and insulin.resultspersistent ...
allotransplantation is currently viewed as the preferred solution for the treatment of end - stage organ failure . however , only a small percentage of those patients who could benefit from this therapy receive it due to a shortage of donor organs . this shortage of donors has stimulated interest in the possible use ...
micropigs are the most likely source animals for xenotransplantation . however , an appropriate method for evaluating the lung of micropigs had not been established . therefore , this study was performed to evaluate the feasibility of 64-channel multi - detector row computed tomography ( mdct ) to measure the diamete...
birds reproduce within electromagnetic fields ( emfs ) from transmission lines . melatonin influences physiologic and behavioral processes that are critical to survival , and melatonin has been equivocally suppressed by emfs in mammalian species . we examined whether emfs affect photophasic plasma melatonin in repr...
the prerequisites for good adhesion of the composite resin to the tooth structure , is that the adherent surfaces be clean and compatible , which is often difficult to attain and maintain . as the tooth surface is altered by rotary and manual instrumentation during cavity preparation , the smear layer is generated . ...
aims : the objective of thisstudy is to evaluate and compare 4% titanium tetrafluoride with 2% sodium fluoride , and the bond strength of composite resin with dentin and their effects on the smear layer.materials and methods : fifty freshly extracted non - carious molar and premolar teeth were selected . the occlusal...
the 2009 pandemic influenza a virus ( h1n1 ; hereafter , h1n1 2009 ) was reported for the first time in mexico in april 2009 and subsequently spread globally . the virulence of the h1n1 2009 virus was not higher than that of seasonal influenza viruses , but the h1n1 2009 virus had higher transmissibility . for this...
clinical and laboratory data from western countries suggest that pregnant women are at an increased risk for severe illness and complications associated with 2009 pandemic influenza a ( h1n1 ) . however , previous data among korean women suggested a less severe outcome . in this study performed at a single referral cen...
tongue diagnosis is one of the important contents of four diagnoses in traditional chinese medicine ( tcm ) . the four diagnoses means observation , listening , interrogation , and pulse - taking . traditional tongue diagnoses depend on observations of tongue features such as color , shape , moisture , and text...
tongue image with coating is of important clinical diagnostic meaning , but traditional tongue image extraction method is not competent for extraction of tongue image with thick coating . in this paper , a novel method is suggested , which applies multiobjective greedy rules and makes fusion of color and space inform...
bipolar affective disorder ( bpad ) is a major psychiatric problem with multifactorial etiology affecting approximately 1% of population and with all other bipolar spectrum disorders the prevalence will be as high as 5% . bipolar disorder is the sixth leading cause of medical disability world - wide among people 15 -...
aim : the aim of our study was to investigate whether the tandem repeat polymorphism in d18s452 microsatellite marker at locus 18p11.2 is a risk factor of bipolar affective disorder ( bpad ) in kashmiri population.materials and methods : the repeat polymorphism in d18s452 was evaluated by polymerase chain reaction ( pc...
this work has been supported by fundaci la marat de tv3 with grant # 20131210 and instituto de salud carlos iii - feder with grant # pi13/00448
abstractmutations in kras and braf genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance . we have identified phosphorylated p45-ikk as an essential mediator of braf - induced tumorigenesis . importantly , endosomal acidification inhibitors preclude phosphorylatio...
chromium , though a micronutrient naturally present , can lead to life threatening complications when ingested in high levels . it is a rare poison and is associated with life threatening complications involving various organ systems . r , a 21-year - old gentleman from south india , who worked in a cellphone shop ...
a 21-year - old gentleman , a worker in a mobile phone shop , was admitted with rhabdomyolysis , renal failure , and pulmonary edema requiring mechanical ventilation and hemodialysis . after extensive workup and ruling out other causes , heavy metal poisoning was considered . investigations during the course of the...
the four chemicals ( purity 98% ) , and tcdd , 98% ( cambridge isotopes laboratories inc . , andover , ma , usa ) were dissolved in dimethyl sulfoxide ( dmso ) ( bdh laboratory supplies , pool , uk ) . louis , mo , usa ) was dissolved in 96% ethanol ( extra pure ; merck , darmstadt germany ) . luciferin and fluore...
backgroundan array of environmental compounds is known to possess endocrine disruption ( ed ) potentials . bisphenol a ( bpa ) and bisphenol a dimethacrylate ( bpa - dm ) are monomers used to a high extent in the plastic industry and as dental sealants . alkylphenols such as 4-n - nonylphenol ( nnp ) and 4-n - octy...
they are usually small , quite round and noncompressive3 ) . magnetic resonance imaging ( mri ) cranial mri showed a left - sided choroidal fissure cyst measuring 45 mm ( fig . the cyst was hemorrhagic and showed fluid - fluid level on t2-weighted and susceptibility weighted images . she was followed conservative...
choroidal fissure cysts are often incidentally discovered . they are usually asymptomatic . the authors report a case of growing and hemorrhagic choroidal fissure cyst which was treated surgically . a 22-year - old female presented with headache . cranial mri showed a left - sided choroidal fissure cyst . follo...
emphysematous pyelonephritis , a less frequently noticed acute clinical condition , is invariably associated with uncontrolled diabetes or immune suppression . infective renal mass with gas lucencies is the hall mark with associated pyrexial and septic state . asymptomatic incidental detection of the condition duri...
the authors report an interesting coincidental unearthing by 18f - fluorodeoxyglucose positron emission tomography / computed tomography ( 18f - fdg pet / ct ) of a potentially serious medical condition of emphysematous pyelonephritis in a case of nasopharyngeal carcinoma . the management by conservative ureteric ste...
karen lawson , md , abihm , an assistant professor of university of minnesota 's family medicine and community health , is director of integrative health coaching at the center for spirituality & healing ( www.csh.umn.edu ) . she is a physician , board - certified in both family medicine and integrative and holistic ...
in september 2014 , global advances in health and medicine editor michele mittelman , rn , mph , interviewed four of the leaders in health and wellness coaching about trends in coaching and the progress of the national consortium for credentialing of health & wellness coaches . following are the transcripts of those in...
asthma is a common chronic illness that results in significant burden for patients , families , and the health care system as well as significant preventable asthma morbidity and mortality ( yawn 2003 ; savage - brown et al 2005 ; kelley et al 2005 ; canino et al 2006 ; yawn et al 2007 ) . among primary care practices ...
objective : primary care asthma management is often not compatible with national evidence - based guidelines . the objective of this study was to assess the feasibility and impact of the asthma apgar tools to enhance implementation of asthma guideline - compatible management in primary care practices.subjects:twenty-...
male androgenetic alopecia ( aga ) , also called male pattern baldness , is a frequent disorder characterized by progressive hair and follicular miniaturization in a very similar pattern among affected men that is classified according to the hamilton norwood scale . genetic predisposition , androgens , and aging are...
context : androgenetic alopecia ( aga ) is a frequent disorder characterized by progressive hair miniaturization in a very similar pattern among all affected men . the pathogenesis is related to androgen - inducible overexpression of transforming growth factor -1 from balding dermal papilla cells , which is involved ...
anesthetic management of patients with severe malformations of the skeletal system can be very challenging due to altered anatomy and physiology.1 here , we report a case of ultrasound - guided epidural block in combination with low - dose ketamine during cesarean section on a patient with severe malformations of the s...
anesthetic management of patients with preexisting diseases is challenging and individualized approaches need to be determined based on patients complications . we report here a case of ultrasound - guided epidural anesthesia in combination with low - dose ketamine during cesarean delivery on a parturient with severe...
until 2006 , only 100 cases had been reported in the world literature of akc , the nevoid and the rarest of the five varieties of angiokeratomas . it is confirmed histopathologically by hyperkeratosis , papillomatosis , and acanthosis with its vascular proliferation restricted to the papillary dermis , the latter dif...
a 20-year - old male presented with multiple eruptions on his right leg since birth ; these bled and were painful on trivial trauma . examination revealed dark brown , hyperkeratotic , indurated , verrucous linear plaques with irregular borders . histopathological evidence of hyperkeratosis , acanthosis , and exten...
cerebral amyloid angiopathy ( caa ) is the deposition of amyloid proteins in the cerebrovasculature . caa is a well - known and relatively common etiology for intracerebral hemorrhage ( ich ) , with a predilection for the meningocortical vasculature . in the elderly while caa is a relatively frequent cause of ich ,...
cerebral amyloid angiopathy ( caa ) is the deposition of amyloid proteins in the cerebrovasculature , which can lead to intracerebral hemorrhage . intracerebral hemorrhage in caa often presents with microhemorrhages and , less frequently , with more devastating macrohemorrhages . we present a case of caa - related ...
type 1 diabetes mellitus ( iddm ) results from autoimmune destruction of insulin producing beta cells and is characterized by the presence of insulitis and beta cell auto antibodies . it is associated with other autoimmune endocrine disorders and auto antibodies leading to the development of autoimmune polyglandular ...
aims and objectives : to estimate serum vitamin b12 levels in type 1 diabetes and to evaluate the influence of duration of diabetes , diabetic control , and age on b 12 levels.importance of study : vitamin b12 deficiency is known to be associated with autoimmune disorders . however , currently there is very limited and...
merkel cell carcinoma ( mcc ) is an uncommon cutaneous malignancy with an estimated 1,500 cases diagnosed annually in the us . it is most commonly seen in men in their 70s and on sun - exposed skin . moreover , when it is found in immunosuppressed patients , the clinical course can be more fulminant . the cell of o...
merkel cell carcinoma ( mcc ) typically presents as an isolated cutaneous lesion with a measurable risk of regional lymph node involvement . uncommonly , synchronous or metachronous lesions have been described to be attributed to a field effect . this case report describes a patient presenting with metachronous les...
epit helial ovarian cancer ( eoc ) remains the gynecological cancer with the highest mortality because over two - thirds of patients have advanced disease upon diagnosis . only 10% of cases are due to an inherited predisposition , while the majority are attributable to alterations in brca1 and brca2 , which present t...
purposethe purpose of this study was to investigate the clinical features of epithelial ovarian cancer ( eoc ) patients according to brca1/2 mutation status ( mutation , variant of uncertain significance [ vus ] , or wild type).materials and methodswe analyzed 116 patients whose brca1/2 genetic test results were availa...
the use of whole body vibration ( wbv ) has become an increasingly popular method of training for enhancing performance in sport . significant improvements in performance have been demonstrated across a wide spectrum of sporting activities with the use of wbv training . the most common improvements are seen in expl...
whole body vibration ( wbv ) is characterized by a vibratory stimulus emitted throughout the body through the use of a vibrating platform on which the subject stands . studies have shown over 30% increases in maximal explosive strength such as maximal speed biceps curl as well as increases in maximum dynamic force su...
the planar cell polarity ( pcp ) pathway maintains cell polarity in the plane of epithelial tissues in drosophila melanogaster embryos through the complex interplay of several core molecular components , including frizzled , dishevelled , strabismus ( stbm ) , and prickle ( tree et al . , 2002 ) . the same proteins...
the planar cell polarity ( pcp ) pathway organizes the cytoskeleton and polarizes cells within embryonic tissue . we investigate the relationship between pcp signaling and cell fate determination during asymmetric division of neural progenitors ( nps ) in mouse embryos . the cortex of lp / lp ( loop - tail ) mice d...
dyadic , traditional senior to junior mentorship , relationships have been shown to have both career and psychosocial functions and usually proceed through several stages before often concluding . peer or collaborative mentorship relationships , a partnership with members of the same approximate age and/or career sta...
introduction . mentoring relationships have been shown to support academicians in areas of research , work / life balance , and promotion . methods . general pediatric division chiefs accessed an electronic survey asking about mentorship relationships , their ability to create a mentorship program , and resources...
eradication of hiv-1 from active and latent reservoirs and achieving a functional cure , defined as long - term undetectable viraemia for an as - yet - undefined period ( probably several years ) in the absence of art , is currently a high priority area for the aids research community and the national institutes of he...
abstractcsf hiv escape is a recently recognised phenomenon that suggests that despite suppressive treatment , hiv rna may be detected in the cns compartment in some individuals . in rare cases this is associated with clinical neurological disease , while in most cases , neurological consequences are not apparent . ...
test materials : diflubenzuron an acylurea compound ( n-[(4-chlorophenyl ) amino ] carbonyl]-2 , 6-difluorobenzamide ) acts as a chitin synthesis inhibitor and is also known as dimilin. three formulations of dimilin , 25 per cent wp , 2 per cent gr and 2 per cent dt were supplied by whopes / who , geneva , switzerland ...
background & objectives : insect growth regulators ( igrs ) offer alternatives to conventional chemical larvicides that pose problem of resistance and environmental safety . however , only a limited number of igrs have been approved for use in mosquito control . in the present study , two new formulations of the igr ...
cancer of cowper 's gland is a rare cancer with fewer than 10 recorded cases [ 1 , 2 , 3 , 4 , 5 , 6 ] . the literature is composed of case reports , primarily predating the modern era of chemotherapy . the reported cases of cowper 's gland carcinoma have all been adenoid cystic carcinoma ( adcc ) , and treatment e...
cancer of cowper 's gland is a very rare cancer . this case represents the 9th case in the medical literature . as such , there are no phase ii or phase iii trials to guide treatment . in this article , we report the successful treatment of a patient over a 7-year period guided solely by molecular profiling . through...
the elbow s susceptibility for stiffness has been described before and multiple factors have been implicated [ 1 , 2 ] . when conservative measures fail , a surgical approach might be indicated . the functional rom has been described by morrey as minimum extension of 30 and flexion up to 130. in particular cases even...
purposethe aim of this study was to evaluate the results of elbow arthrolysis according to the surgical approach , durability after arthrolysis and the severity of contracture.methodsthe study includes a cohort of 100 consecutive patients treated in our institution between 1986 and 2008 . the indication for surgery w...
achieving optimal femoral component rotational alignment in total knee arthroplasty ( tka ) is crucial in establishing a balanced knee reconstruction and ensuring adequate patello - femoral tracking.110 unbalanced knees can lead to instability , patellofemoral problems , persistent pain , stiffness , and generally poor...
background : optimal femoral component rotational alignment in total knee arthroplasty ( tka ) is crucial to establish a balanced knee reconstruction . unbalanced knees can lead to instability , patellofemoral problems , persistent pain , stiffness , and generally poorer outcomes including early failure . intraoper...
the interplay between the gut , the normal microbiota and gut pathogens has received particular attention in recent years ( for review see refs . 1 - 3 ) , however , many aspects still need to be investigated . for instance , it is of interest to identify bacterial genes , which are specifically expressed in the gut ...
bacteria survive under various conditions by sensing stimuli triggering specific adaptive physiological responses , which are often based on membrane - integrated sensors connected to a cytoplasmic regulator . recent studies reveal that mucus glycans may act as signal molecules for two - component systems involved in...
diabetes mellitus ( dm ) is one of the most challenging and burdensome chronic diseases of the 21st century.dm currently affects about 285 million adults worldwide and it is expected to rise to over 400 million adults by 2030.diabetes mellitus type 2 is responsible for over 90% of all cases of diabetes . most...
introduction : several adjustment scales are available for diabetes , but , unfortunately most of them focused on the limited dimensions of diabetes and are not specific for type 2 diabetes . the aim of this study was to develop a multidimensional scale for diabetes type 2 adjustment assessment and to test prel...
the organization and remodeling of the actin cytoskeleton are controlled by the rho family of small gtpases , which includes rho , rac , and cdc42 . these proteins have been implicated in the formation of stress fibers , lamellipodia , and filopodia , respectively ( reviewed in hall 1998 ) . although much of our kn...
clone a colon carcinoma cells develop fan - shaped lamellae and exhibit random migration when plated on laminin , processes that depend on the ligation of the 64 integrin . here , we report that expression of a dominant negative rhoa ( n19rhoa ) in clone a cells inhibited 64-dependent membrane ruffling , lamellae for...
psoriasis is a chronic immune - mediated skin disease with a prevalence varying among ethnic groups from 0.91% to 8.5% . psoriatic arthritis ( psa ) is a chronic inflammatory disease affecting about 6 - 10% of patients with cutaneous psoriasis . however , the prevalence of psa is significantly higher ( 20 - 40% ) i...
psoriatic arthritis ( psa ) is a chronic inflammatory disease affecting about 6 - 10% of patients with cutaneous psoriasis . according to current knowledge , activated t - cells seem to play a pivotal role in the pathogenesis of both psoriasis and psa . abatacept is a novel biologic agent selectively designed to in...