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. they may occur as solitary or multiple lesions . in case of multiple lesions numerous small papules and/or large dome - shaped nodules
are present on the scalp like a turban , hence the name turban tumor . scattered nodules are present occasionally on the face and in rare instances on the extremities .
we report ... | dermal cylindroma is a benign neoplasm of the eccrine sweat glands , which presents in the head and neck area in majority of cases . in its most florid presentation ,
the entire scalp can be involved , leading to the descriptive label turban tumor .
they most commonly occur on the head and neck as solitary or multi... |
on may 8 , 2014 , the united states court of appeals for the federal circuit issued an opinion , in re roslin institute , rejecting patent claims to mammals cloned from somatic cells .
the patent at issue covered animals such as the famous cloned sheep , dolly , which had been produced without sexual reproduction fro... | the opinion of the united states court of appeals for the federal circuit , in re roslin institute , rejecting patent claims to mammals cloned from somatic cells , was rendered about a month before the united states supreme court 's decision in alice corp .
v. cls bank international .
the alice opinion explicitly s... |
. the rarity of these lesions does not decrease their importance , as they are a disabling but treatable cause of compressive myelopathy .
most described cases of spinal edh are spontaneous , which may develop from bleeding from arteriovenous malformations , coagulation disorders , thrombolysis , or a coronary event ... | traumatic spinal epidural hematoma ( tseh ) is of rare clinical occurrence .
we report a case of a young man with posttraumatic long - segment spinal epidural hematoma .
evacuation of the hematoma led to complete neurologic recovery in our patient .
our case highlights the importance of early diagnosis and prompt... |
in recent decades ,
the number of drugs brought to market has been
declining , and new low - cost methods for drug discovery are needed . while virtual screening is able to reduce the
total number of ligands that need to be synthesized and screened experimentally , it requires prior knowledge of the target site
... | incorporation of receptor flexibility
into computational drug discovery
through the relaxed complex scheme is well suited for screening against
a single binding site . in the absence of a known pocket or
if there
are multiple potential binding sites , it may be necessary to do docking
against the entire sur... |
it has been estimated that 24% of end - stage renal disease ( esrd ) patient deaths may be attributed to a hemodialysis - related complication .
a survey carried out in 2006 that elicited opinions from patients and health care providers about safety concerns in the hemodialysis unit reported that 50% of the patients ... | backgroundpatients with end - stage renal disease are at high risk for medical errors given their comorbidities , polypharmacy and coordination of care with other hospital departments .
we previously developed a hemodialysis safety checklist ( hemo pause ) to be jointly completed by nurses and patients .
our object... |
a total of 118 histologically confirmed cervicovaginal swab specimens in which hpv infection status was examined by hc2 , between january 2015 and march 2015 at konkuk university medical center , were collected .
cytological diagnosis was obtained in 109 patients using liquid - based cervical cytology ( sure - path ,... | background : human papillomavirus ( hpv ) infection can be detected by using several molecular methods , including hybrid - capture ii ( hc2 ) assay and variable hpv dna chip tests , although each method has different sensitivities and specificities.methods:we performed hpv 9 g dna chip ( 9 g ) and panarray hpv genotyp... |
the goldn participants were predominantly of european ancestry and recruited from two genetically homogeneous centers ( minneapolis , mn , and salt lake city , ut ) . in this study , only 820 participants ( 406 men and 414 women ) of european ancestry were included in our analyses .
the primary aim of goldn was to ex... | objectiveinsulin receptor substrate 1 ( irs1 ) is central to insulin signaling pathways .
this study aimed to examine the association of irs1 variants with insulin resistance ( ir ) and related phenotypes , as well as potential modification by diet.research design and methodstwo irs1 variants ( rs7578326 and rs294364... |
several publications show importance of malaria control and elimination programs for economic progress . in iran over the years , in association with who ( roll back malaria ) and undp programs , considerable amount of effort has been expended by health authorities to control and prevent malaria through various measure... | background . south
eastern parts of iran remain endemic for malaria infection
. there is some concern that malaria infection may spread into bushehr , which is located in the south western part bordering the persian gulf and at the periphery of the declared endemic region hormozgan province due to frequency of visi... |
conventional root canal treatment of necrotic pulp in immature teeth is challenging clinically due to incomplete root development .
several methods have been used to manage the open apex of immature teeth , including apexification with calcium hydroxide ( ca[oh]2 ) or mineral trioxide aggregate ( mta ) .
although t... | an immature maxillary first premolar in an 8-year - old female was treated using a regenerative approach .
the root canal was gently irrigated with 5.25% sodium hypochlorite without instrumentation under aseptic conditions and then medicated with calcium hydroxide ( ca[oh]2 ) for 3 weeks .
the ca(oh)2 was removed ,... |
tooth agenesis is defined as congenital absence of one or a few permanent teeth without any systemic disorders and the prevalence varies from 2.6% to 11.3% ( excluding third molars ) .
peg - shaped is defined as a developmental alteration in dental shape , which incisal mesio - distal width of the tooth crown is narr... | the present report aimed to study an uncommon case of a pair of twins that presented a discordant dental phenotype .
family investigation , clinical , radiographic examination and molecular analysis were performed in both girls .
molecular analysis confirmed the monozygosity by deoxyribonucleic acid chip technology... |
vitamin d is one of the major hormones regulating blood levels of calcium and mineral homeostasis of the bone .
the production of the active hormone , calcitriol or 1,25dihydroxyvitamin d3 ( 1,25(oh)2d ) , results from sequential hydroxylation by members of the cytochrome p450 enzymes 1 .
1,25(oh)2d exerts its biol... | key clinical messagevitamin ddependent rickets type 1 vddr1 is a recessive inherited disorder with impaired activation of vitamin d , caused by mutations in cyp27b1 .
we present longtime followup of a case with a novel mutation including highresolution peripheral quantitative computed tomography of the bone .
adequ... |
advent of faster and miniature computers had cascading effect leading to exponential growth in technology and modern medicine that led to better health care in all age groups and across gender .
significant improvements in maternal and child care indices were noted in india especially in last decade though india miss... | objective . we explored reasons for discharged against medical advice ( dama ) of neonates from a neonatal intensive care unit ( nicu ) through in - depth interviews of the parents / guardians .
methods . of 456 babies admitted to nicu during april 2014 to march 2015 , 116 babies were dama .
parents of randomly sel... |
cardiovascular diseases , the major cause of deaths in western societies and throughout the world , are mainly due to atherosclerosis , a chronic inflammatory disease affecting mainly medium and large arteries ( who , fact sheets of 2016 ) .
local blood flow perturbations or injuries lead to an increased permeability... | macrophages and oxidized ldls play a key role in atherogenesis but their heterogeneity has been neglected up to now .
macrophages are prone to polarization and subsets of polarized macrophages have been described in atheromas .
ldls can be oxidized not only chemically by copper ( ox - ldls ) but also enzymatically ... |
among female students of three medical universities of tehran , iran ( including university of social welfare and rehabilitation sciences ; tehran university of medical sciences ; and islamic azad university , tehran medical branch ) , 600 students were recruited . of the participants , 46 ( 7.6% )
did not agree to p... | objective :
the aim of this study was to provide norms of eating disorder examination questionnaire ( ede - q ) and clinical impairment assessment ( cia ) for undergraduate women in iran .
materials and methods :
undergraduate women ( n = 516 ) completed the ede - q , cia , and the binge eating scale ( bes ) .
... |
it is important to understand the species richness , size , and life history of ectoparasite populations to understand the biology of the host species because of the potential for ectoparasites to impact host fitness .
most ectoparasites of bats show strong coevolutionary ties to their hosts because they never or onl... | prevalence of bat ectoparasites on sympatric myotis lucifugus and m. septentrionalis was quantitatively characterized in nova scotia and new brunswick by making systematic collections at swarming sites .
six species of ectoparasite were recorded , including myodopsylla insignis , spinturnix americanus , cimex adjunct... |
in the course of time , pathologists , anthropologists and radiologists pointed out this situation1,2 ) .
more frequently this condition affects females over 60 years of age with no special reference to race or geographical area1 - 4 ) .
remodelling of the compensatory spongy bone ( diploe ) , due to erosion on the... | thinning of parietal bone bilaterally is extremely rare but well known phenomenon .
approximate prevalence is 0.4 - 0.5% according to radiological scans , case reports and anthropologic researches .
even though biparietal osteodystrophy occurs mostly in over 60-year - old women , it shows no special association wit... |
thyroid hormones are instrumental in regulating the health and appearance of skin and when the thyroid gland becomes underactive or overactive , a variety of skin problems may result .
cutaneous manifestations of hypothyroidism are protean in nature and affect all age groups . these dermatologic manifestations may oc... | background : thyroid disorders are known to involve all the organ systems of the body , the skin being no exception .
the association of thyroid disorders with cutaneous manifestations is complex .
both hypothyroidism and hyperthyroidism are known to cause these changes.aims:the present study was designed to ascert... |
it is a rare entity that has been reported to result most commonly after trauma or spontaneously without underlying cause in healthy adult.1 ) pneumopericardium resulting after pericardiocentesis is even rarer and has been attributed either to a direct pleuro - pericardial communication or to an air leakage to the peri... | pneumopericardium is defined by the presence of air in the pericardial cavity .
it is a rare entity occurring most commonly after trauma .
pneumopericardium resulting after pericardiocentesis is even rarer .
we report a case of 46-year - old man , with end - stage renal disease on chronic hemodialysis and who dev... |
traumatic femur fractures ( ffs ) continue to be a major cause of morbidity and mortality worldwide .
regardless of the patient age and injury severity , a previous study showed that in comparison to delayed stabilization , an early definitive stabilization of ff is found to have fewer complications .
currently the... | background : femur fracture ( ff ) is a common injury , and intramedullary nailing ( imn ) is the standard surgical fixation .
however , the time of intervention remains controversial .
we aimed to describe the reamed imn ( rimn ) timing and hospital outcomes in trauma patients presenting with ff.materials and meth... |
spider bite is endemic in parts of north america , mexico , tropical belt of africa and europe and can cause serious systemic manifestations .
loxosceles spiders belong to the family loxoscelidae / sicariidae . of the 13 species of loxosceles
loxosceles reclusa , or the brown recluse spider , is the spider most com... | spiders of the loxosceles species can cause dermonecrosis and acute kidney injury ( aki ) .
hemolysis , rhabdomyolysis and direct toxin - mediated renal damage have been postulated .
there are very few reports of loxoscelism from india .
we report a case of aki , hemolysis and a gravitational pattern of ulcerat... |
neonatal monosodium l - glutamate ( msg ) administration induces morphological , behavioral , and neuroendocrine abnormalities such as growth disturbances , self - mutilation , hyperadiposity , and hypogonadism [ 14 ] .
it has been assessed that catecholaminergic and peptidergic neuronal loss takes place in the retin... | rats neonatally treated with monosodium l - glutamate ( msg ) are deeply dysfunctional in adulthood .
we explored the effect of an oral low dose of metformin treatment in male msg rats on adipoinsular axis and visceral adipose tissue ( vat ) dysfunctions , in both basal ( nonfasting ) and endotoxemia conditions .
m... |
their complications are nutritional , psychiatric , and physical health disturbances ( 1 , 2 ) . eating disorders vary from nonclinical eating disorders , as feeling of being too fat or dieting , to severe clinical forms , as anorexia nervosa and bulimia nervosa ( 2 , 3 ) .
eating disorders are more common at the age... | background : abnormal eating behavior , unhealthy weight control methods , and eating disordered symptoms have risen among college students.objectives:the aim of this study was to examine disordered eating attitudes and their relationship with anthropometric and body composition indices in physical education students i... |
viral hepatitis b is a serious health problem throughout the world , being a leading cause of acute and chronic liver disease including cirrhosis and primary liver cancer , which ranks as the 3rd cause of cancer deaths worldwide .
globally , over 350 million people are chronic carriers of hepatitis b virus ( hbv ) , ... | summarythis article reviews topics covered and discussed at the meeting : " vaccini e vaccinazioni .
migliorare l'oggi e preparare il domani " , held in genoa , italy , on 12 september 2014 .
data presented at the meeting , clearly showed that : 1 ) hepatitis b vaccination can confer long - term protection and ther... |
arising from hydro - geological interactions within riverine systems , elements and metals coexist in relative proportions to each other and these ratios are dependent on geochemical processes such as weathering , atmospheric deposition , rainfall and flow - rates .
overall , this process occurs from a dynamic equili... | the application of an acid digestion and subsequent solid - phase extraction ( spe ) procedure were implemented as preliminary treatments prior to quantifying the levels of potentially endocrine disrupting metals ( edms ) in a variety of solid and liquid matrices .
these included ( solid ) river sediment , leachate s... |
we are reporting the first - to our knowledge - case of duodenal plexiform fibromyxoma causing obscure upper gastrointestinal bleeding .
plexiform fibromyxoma triggered recurrent upper gastrointestinal bleeding episodes in a 63-year - old man who remained undiagnosed , despite multiple hospitalizations , extensive di... | abstractrationale : we are reporting the first - to our knowledge - case of duodenal plexiform fibromyxoma causing obscure upper gastrointestinal bleeding.patient concerns : plexiform fibromyxoma triggered recurrent upper gastrointestinal bleeding episodes in a 63-year - old man who remained undiagnosed , despite multi... |
tobacco smoking is known to be an important contributor to a wide variety of chronic diseases including chronic obstructive pulmonary disease , lung cancer , cardiovascular disease , and cancers of various organs .
tobacco smoking also negatively affects several other respiratory diseases , including pneumonia and pu... | backgroundtobacco smoking is known to be an important contributor to a wide variety of chronic diseases , especially in older adults .
information on health policy and practice , as well as evaluation of smoking cessation programs targeting older people , is almost nonexistent.purposeto compare the real - world imple... |
the goals of health and social care interventions in the field of ischaemic heart disease are placing increasing emphasis on patients ' quality of life as well as quantity of life and an improvement in health - related quality of life ( hrqol ) is often a stated goal of many cardiac rehabilitation programmes and second... | backgrounda previous review suggested that the macnew quality of life questionnaire was the most appropriate disease - specific measure of health - related quality of life among people with ischaemic heart disease .
however , there is ambiguity about the allocation of items to the three factors underlying the macnew ... |
environmental and occupational
sources continue to make lead exposure a health hazard , despite the
restrictions to use lead in gasoline and paints over the past few
decades .
the largest current industrial use of lead is in production
of lead - acid batteries for automobiles .
lead persists
in drinking w... | a spectroscopic
investigation of the complexes formed between the pb(ii ) ion and d - penicillamine ( h2pen ) , a chelating agent used in
the treatment of lead poisoning , was carried out on two sets of alkaline
aqueous solutions with cpb(ii )
10 and 100 mm , varying the h2pen / pb(ii ) molar ratio ( 2.0 ,
3... |
two strong correlates of aging are mitochondrial dysfunction ( sastre et al . , 2003 ; sedensky and morgan , 2006 ; figueiredo et al . , 2008 ; wei et al . , 2009 ) and accumulation of altered proteins ( hipkiss , 2006a ; soskic et al . , 2007 ; lindner and demarez , 2009 ) .
it is possible that both these apparent e... | it is suggested that nad+ availability strongly affects cellular aging and organism lifespan : low nad+ availability increases intracellular levels of glycolytic triose phosphates ( glyceraldehyde-3-phosphate and dihydroxyacetone - phosphate ) which , if not further metabolized , decompose spontaneously into methylglyo... |
convulsions and loss of consciousness in patients can be caused by arrhythmias , conduction disorders or epilepsy .
when syncope is misinterpreted as epilepsy , this may not only lead to the unnecessary use of anticonvulsant drugs but , more importantly , life - threatening arrhythmias can be missed which may lea... | convulsions and loss of consciousness can be caused by , among other things , arrhythmias , conduction disorders or epilepsy . in clinical practice
it can be difficult to distinguish between these causes of syncope , even for well - trained specialists .
patients with cardiac syncope have a substantial risk of subs... |
visceral leishmaniasis ( vl ) or kala - azar is caused by various species of leishmania donovani complex , and children are particularly most affected by this infection in endemic areas .
vl is distributed in 98 countries and 3 territories and approximately 200,000 to 400,000 cases of new types of human vl occur arou... | visceral leishmaniasis ( vl ) or kala - azar mainly affects children in endemic areas .
this study was conducted to determine the seroprevalence of vl using direct agglutination test ( dat ) in children living in rural districts of alborz province located 30 km from tehran capital city of iran . multi - stage cluster... |
there are three phases in the natural history of chronic hbv infection ( 1 ) .
the first is the immune - tolerant phase ( itp ) defined by hepatitis b e antigen ( hbeag)-positive , normal hepatic enzyme levels and high serum hbv dna concentrations .
the second is the immune - clearance phase ( icp ) defined by hbea... | the precore ( g1896a ) and core promoter ( a1762 t , g1764a ) mutations of the hepatitis b virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults . we analyzed these mutations in chronically hbv - infected children .
serum was collected from 3... |
lung cancer is the third - most commonly diagnosed cancer and the leading cause of cancer - related deaths in the united states .
over 220,000 new cases of lung cancer are expected to be diagnosed in 2015 while more than 158,000 people are expected to die from lung cancer that same year .
worldwide , lung cancer is... | lung cancer is the third most commonly diagnosed cancer and the leading cause of cancer - related death in the united states . unlike non - squamous nsclc , squamous nsclc rarely harbor epidermal growth factor receptor ( egfr ) and anaplastic lymphoma kinase ( alk ) mutations for which there are directed therapies , an... |
functional annotation of putative proteins is a fundamental and essential practice in the postgenomics era ; it allows us to analyze genomic and genetic features , such as physiological activity and metabolism , as well as to discover medically and industrially relevant enzymes .
since large numbers of putative prote... | owing to the generation of vast amounts of sequencing data by using cost - effective , high - throughput sequencing technologies with improved computational approaches , many putative proteins have been discovered after assembly and structural annotation .
putative proteins are typically annotated using a functional ... |
virtual reality technique can be combined with targeted exergames development with the aim to promote motor rehabilitation .
recently , a number of researchers have pointed to the potential of virtual reality applications in health care [ 6 , 20 , 28 , 36 , 48 , 50 ] and hence sparked the introduction of this technol... | virtual rehabilitation approaches for promoting motor recovery has attracted considerable attention in recent years .
it appears to be a useful tool to provide beneficial and motivational rehabilitation conditions . following a stroke ,
hemiparesis is one of the most disabling impairments and , therefore , many aff... |
crohn 's disease ( cd ) and ulcerative colitis ( uc ) are the two most common forms of inflammatory bowel diseases ( ibd ) , characterized by chronic and recurrent inflammation of the gastrointestinal tract
. the etiology and pathogenesis of uc and cd are multifactorial and include genetic , environmental , and immun... | reactive oxygen species- ( ros- ) mediated injury has been implicated in several inflammatory disorders , including inflammatory bowel disease ( ibd ) .
nadph oxidases ( noxs ) are the major source of endogenous ros . here , we investigated the role of noxs derived - ros in a mouse model of colitis induced by the pro... |
diabetes is an ever - growing chronic metabolism defect all over the world ( seghrouchni et al .
lifelong and requiring constant follow up and treatment , diabetes mellitus ( dm ) decreases the patient s quality of life considerably because of its acute and chronic complications ; it is a chronic , metabolic disease ... | this study was conducted with the purpose of researching the effect of lycopene application on lipoprotein , paraoxonase ( pon ) and cytokines that are projected to be used in the diagnosis and treatment of diabetes by making experimental diabetes . at the end of a 1-month trial period , under ether anesthesia with jel... |
delinquency is positively associated with sexual abuse and family conflict ( widom , 1989 ) , and negatively associated with parental warmth and support ( hoeve et al . , 2008 ) . while some evidence shows that specific genotypes , in interaction with childhood adversity , confer vulnerability for delinquency , several... | background : previous evidence of gene - by - environment interactions associated with emotional and behavioral disorders is contradictory .
differences in findings may result from variation in valence and dose of the environmental factor , and/or failure to take account of gene - by - gene interactions .
the prese... |
in a prospective double - blind randomized controlled trial , we tried to find out whether coblation technique decreases the postoperative morbidity compared to traditional dissection tonsillectomy .
operation time , intraoperative blood loss , postoperative pain , number of days needed to return to work and normal d... | background : coblation tonsillectomy is a new surgical technique and demands further research to be proven as a suitable and standard method of tonsillectomy .
this study compares coblation and traditional tonsillectomy techniques in view of their advantages and complications.methods:in a prospective double - blind r... |
keratoconus is a bilateral and chronic progressive disease . due to different definitions and diagnostic criteria
histological findings include stromal thinning , iron deposition in the epithelial basement membrane , and breaks in bowman 's layer .
the etiology and pathogenesis of keratoconus is still unknown but m... | aim .
the aim of this study was to determine the intra- and interobserver variability of two scheimpflug based camera systems , pentacam and sirius .
in addition , the comparability of the measurements was tested in healthy subjects , subjects with regular astigmatism , and keratoconus patients .
methods .
intr... |
recently , robotic systems have been introduced to various surgical fields , including urologic surgery . in 2001 ,
binder and kramer performed the first robot - assisted laparoscopic prostatectomy ( ralp ) . in 2005 , the first domestic ralp was performed with the da vinci robot system .
in general , robotic surge... | purposeto investigate the learning curve for robot - assisted laparoscopic radical prostatectomy ( ralp ) for pathologic t2 disease , we examined differences in perioperative outcomes according to time period.materials and methodsbetween july 2005 and june 2008 , a total of 307 consecutive patients underwent ralp for p... |
in asthmatics , the aim of treatment is to achieve and maintain the best possible control of the disease , defined as absence of symptoms , no exacerbations , and no limitation of activities , together with the best attainable lung function .
several studies in recent years have shown that optimal control of asthma c... | the mainstay of management in asthma is inhalation therapy at the target site , with direct delivery of the aerosolized drug into the airways to treat inflammation and relieve obstruction .
abundant evidence is available to support the concept that inflammatory and functional changes at the level of the most peripher... |
cyclophosphamide is an alkylating agent used to treat a variety of malignancies and autoimmune disorders .
the combination of cyclophosphamide with doxorobucin ( ac ) or docetaxel ( tc ) is widely used to treat breast cancer in both adjuvant and metastatic settings .
cyclophosphamide is a prodrug and needs to be me... | abstractbackgroundcyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies .
symptomatic hyponatremia can be a rare but life - threatening complication in patients treated with cyclophosphamide.case presentationswe report 2 patients who presented with severe acute hyponatr... |
it has been estimated that viruses cause up to 90% of lower respiratory infection ( lri ) hospitalizations in children less than 5 years of age and up to 40% of hospitalizations in children age 518 years . among the most common causes of viral respiratory infection in children and adults
are respiratory syncytial vir... | viruses are frequent causes of respiratory infection , and viral respiratory infections are significant causes of hospitalization , morbidity , and sometimes mortality in a variety of patient populations .
lung inflammation induced by infection with common respiratory pathogens such as influenza and respiratory syncy... |
the global burden of disease ( gbd ) is a an essential tool in the global battle to improve health .
this project provides a systematic approach to calculating comprehensive , consistent , and comparable measures of health loss due to diseases , injuries , and their associated risk factors .
the latest gbd study , ... | the global burden of disease ( gbd ) study has been instrumental in guiding global health policy development since the early 1990s . the gbd 2010 project provided rich information about the key causes of mortality , disability - adjusted life years , and their associated risk factors in japan and provided a unique oppo... |
chronic alcohol consumption is the most prevalent etiologic factor of hepatic fibrogenesis and cirrhosis ( 1 ) .
ethanol is metabolized primarily by the alcohol dehydrogenase and the cytochrome p450 systems ( 2 ) .
acetaldehyde generated by these oxidative pathways is accumulated due to slow kinetics of its oxidizi... | ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 ( tgf-1 ) expression in animal studies .
tgf-1 is related with the hepatic stellate cell ( the key element of hepatic fibrogenesis ) and the radial glia ( the key element of neuronal migration ) .
blood samples were collected from 41 ... |
an 81-year - old woman with history of melanoma presented to the emergency department with a chief complaint of dyspnea and fatigue .
initial laboratory work - up revealed anemia , with hemoglobin of 7.6 gm / dl and hematocrit of 23.8% .
liver function tests revealed alkaline phosphatase 819 unit / l , ast 131 unit... | an 81-year - old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy .
primary cutaneous malignant melanoma with gastric metastases is a rare occurrence , and it is often not detected until autopsy because of its non - spe... |
nondiabetic hcv - infected subjects between age 18 and 60 with detectable hepatitis c viral load ( hcv rna ) were recruited from san francisco general hospital ( sfgh ) at the university of california san francisco ( ucsf ) and other ucsf - affiliated clinics .
the american diabetes association criterion of fasting g... | objectiveinsulin resistance , as measured by surrogate markers , is associated with lower response to hepatitis c virus ( hcv ) therapy and may improve with hcv eradication .
we prospectively evaluated the impact of directly measured insulin resistance and abnormal glucose metabolism on achieving sustained virologic ... |
fecal incontinence ( fi ) following corrective surgeries of anorectal malformations ( arms ) represents a devastating problem which often prevents the child from becoming socially acceptable , which in turn provokes serious psychological problems .
various treatment strategies have been tried , however , majority of ... | background : anorectal malformation ( arm ) is one of the most common pediatric surgical problems dealt in day - to - day practice .
although the outcome of surgery has improved a great deal over the last three decades fecal incontinence ( fi ) is still a common long - term morbidity that affects the quality of life ... |
although many nanocarriers have been
developed to encapsulate paclitaxel
( ptx ) , the drug loading and circulation time in vivo always are not ideal because of its rigid brickdust
molecular structure .
people usually concentrate their attention on
the spherical nanocarriers , here paclitaxel nanoparticles ... | |
electron attachment to co2 embedded
in superfluid he
droplets ( co2@he ) is studied in a crossed beams experiment
with mass spectrometric detection of the anions . over the past few
years
electron attachment and/or electron ionization for a variety
of molecules embedded in he droplets , including h2o , chcl... | electron attachment to co2 embedded in superfluid he
droplets leads to ionic complexes of the form ( co2)n and ( co2)no and , at much lower intensities ,
he containing ions of the form hem(co2)no. at low
energies ( < 5 ev ) , predominantly the non - decomposed complexes ( co2)n are formed
via two resonance cont... |
the iranian traditional medicine is one of the branches of complementary medicine and it is based on using the dosage forms of plants .
one of the most common forms of pharmaceutical plants is aragh . due to ease - of - use ,
, it is attempted to study the usage forms and effects of aragh according to the valid tra... | background : the iranian traditional medicine is one of the branches of complementary medicine and it is based on using the dosage forms of plants .
one of the most common forms of pharmaceutical plants is aragh . due to ease - of - use ,
distillate is a more acceptable form among the public . in this article
, i... |
immunoglobulin g ( igg)4-related disease ( igg4-rd ) is a relatively recently described systemic , fibro - inflammatory disorder that affects multiple organ systems , including commonly the orbits.1 reports have identified igg4-rd as an etiology of previously described cases of orbital inflammatory disease or pseudotum... | purposeto investigate the relationship between immunoglobulin g ( igg)4-related disease ( igg4-rd ) and thyroid eye disease ( ted ) with respect to igg levels.patients and methodsa retrospective review of total igg , igg subclass , and thyroid stimulating immunoglobulin ( tsi ) levels in 24 patients with ted.resultsfiv... |
the filarial parasite loa loa causes a chronic infection in humans that has two very characteristic clinical features : calabar swellings ( localized angioedema found predominantly on the extremities ) and subconjuctival migration of the adult parasites ( " eyeworm " ) ( 1 ) .
since two initial reports of suspected l... | loa loa is unique among the human filariae in that adult worms are occasionally visible during subconjuntival migration . a 29-yr - old african female student , living in korea for the past 5 yr without ever visiting her home country , presented with acute eyelid swelling and a sensation of motion on the left eyeball .... |
anterior cruciate ligament ( acl ) dysfunction leads to the progression of osteoarthritis and adjacent tissue damage caused by knee instability1 ) .
the goal of acl reconstruction is to restore the normal stability and kinetics of the knee joint .
factors that can influence the outcomes of an acl reconstruction inc... | purposeto compare the clinical results of single - bundle anterior cruciate ligament ( acl ) reconstruction using the conventional transtibial technique and the anatomical outside - in technique for femoral tunneling.materials and methodsfrom 2007 to 2011 , 89 patients who received acl reconstruction were followed for ... |
the characterization of molecular determinants of cancer has advanced tremendously in the past decades , mainly due to advancements in high - throughput technologies .
mass spectrometry ( ms)-based proteomics has undergone enormous improvements in the past few years because of more accurate instrumentation and bett... | summaryour understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity . here
, using epithelial ovarian cancer ( eoc ) as a model system , we analyzed a minute amount of patient - derived epithelial cells from either healthy or cancerous tissues by single - shot mass - s... |
germ cell cancer occurs relatively infrequently , but it is one of the most common malignancies in men aged 1535 years .
extragonadal germ cell tumours , which account for only 26% of all germ cell cancer , tend to arise from the midline of the body , namely the pineal gland , mediastinum , retroperitoneum , lung par... | primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy .
we describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for hodgkin lymphoma ( hl ) .
a 25-year - old man with classic hl , nodular sclerosis subtype , underwent treatment with splenectomy fol... |
in taiwan , the practice of using chinese medicine in combination with western medicine to treat cancer patients is on the rise . in this study , we treated head and neck as well as lung cancer patients undergoing radiotherapy or chemotherapy with sha shen mai men dong tang ( smd-2 ; sh shn mi dng tng ) , a mixture of... | sha shen mai men dong tang ( smd-2 ; sh shn mi dng tng ) is a chinese medicinal herb ( cmh ; zhng co yo ) used to treat symptoms associated with cancer therapy .
the objective of this study was to assess the effect of smd-2 on the levels of urinary copper ( cu ) , zinc ( zn ) , and selenium ( se ) in lung cancer pa... |
biofilms are exploited in a wide range of biotechnologies , including wastewater treatment , biofuel production and the generation of electricity in microbial fuel cells [ 16 , 21 ] .
conversely , however , they generate billions of dollars in losses each year through machinery damage , loss of processing and manufac... | aggregation of bacteria plays a key role in the formation of many biofilms .
the critical first step is cell cell approach , and yet the ability of bacteria to control the likelihood of aggregation during this primary phase is unknown . here
, we use optical tweezers to measure the force between isolated bacillus ... |
the durable trial ( assessing the durability of basal vs. lispro mix 75/25 insulin efficacy ) was a global study with the primary objective of comparing the efficacy , safety , and durability of two starter insulin regimens in patients with type 2 diabetes ( 14 ) .
the durable trial was conducted in accordance with t... | objectiverecent studies have reported hemoglobin a1c ( hba1c ) differences across ethnic groups that could limit its use in clinical practice .
the authors of the a1c - derived average glucose study have advocated to report hba1c in estimated average glucose ( ag ) equivalents .
the aim of this study was to assess ... |
diabetes mellitus ( dm ) is a chronic disease characterized by high blood glucose levels caused by either insufficient insulin production by the pancreas or improper response of the body cells to insulin . approximately 366 million people were diagnosed with dm worldwide in 2011 and this is expected to increase to 552 ... | diabetes mellitus ( dm ) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century .
it is caused by defects in insulin secretion or insulin action or both , leading to hyperglycemia .
of the various types of dm , type 2 occurs most frequently .
multiple genes and thei... |
giant cell myocarditis ( gcm ) is a rare and often fatal disorder that used to be a postmortem diagnosis until the last quarter of the 20th century . with the advent of endomyocardial biopsy
it generally affects healthy and young individuals with mean age of 42 years ( 1560 yrs ) with no propensity for gender or eth... | giant cell myocarditis is an aggressive form of this condition that is typically progressive and unresponsive to usual medical treatment . here , we describe a 34-year - old patient presenting with incessant ventricular arrhythmias with hemodynamic compromise who required prolonged support in intensive care with an int... |
antisense oligonucleotides ( aso ) bind to their cognate mrna in cells and modulate rna function . however , unmodified oligonucleotides are highly unstable in biological media and require stabilization , either with chemical modifications or by formulation with cationic lipid based delivery vehicles , for use in anima... | we report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides ( asos ) modified with -l - locked nucleic acid ( lna ) and related modifications targeting phosphatase and tensin homologue ( pten ) messenger rna in mice .
-l - lna represents the -anomer of enantio - l... |
pleomorphic adenoma is the most frequently occurring benign epithelial tumor of the salivary gland 1 .
the neoplasm is histopathologically characterized by being diverse , consisting of polygonal epithelial cells forming ductal structures surrounded by myoepithelial cells .
typically , a transition from epithelial ... | there are well known that wnt signaling was some roles of cell differentiation at the development tissues , especially the oral and maxillofacial regions of some developmental stages .
therefore , to determine wnt signaling in the pleomorphic adenoma tissues , we examined .
the expression of wnt1 and -catenin as we... |
periodontal diseases are chronic inflammatory conditions characterized by loss of connective tissue , alveolar bone resorption and formation of periodontal pockets as a result of the complex interaction between pathogenic bacteria and the host 's immune response .
periodontitis starts with inflammatory lesions of the... | aim : the aim of this study is to compare the antiplaque efficacy of green tea catechin mouthwash with chlorhexidine gluconate mouthwash.materials and methods : a single blinded cross - over study was conducted among 30 participants in the age group of 18 - 25 years .
the mouthwash samples for the study were previous... |
the replacement of pt
and pt alloys with non - precious - metal - based catalysts for oxygen reduction
reaction ( orr ) is considered the holy grail for electrocatalysis - related
efforts .
most early studies were primarily
focused on pyrolysis of macrocycles containing an existing metal
later , however , i... | detailed
understanding of the nature of the active centers in non - precious - metal - based
electrocatalyst , and their role in oxygen reduction reaction ( orr )
mechanistic pathways will have a profound effect on successful commercialization
of emission - free energy devices such as fuel cells .
recently , ... |
double balloon enteroscopy ( dbe ) consists of an enteroscope and an overtube with a balloon located at either distal end . with a success rate up to 89% and a low complication rate ranging from 0.8% to 4% , common therapeutic applications of dbe include biopsy and tattooing of small bowel lesions , hemostasis , polype... | double balloon enteroscopy ( dbe ) is a revolutionary procedure in which the entire small bowel can be visualized endoscopically .
dbe has the advantage of both diagnostic and therapeutic capabilities in the setting of small bowel neoplasms and vascular malformations .
we present a unique case of a 76-year - old fe... |
the diagnosis can be elusive , since there is no pathognomonic sign or symptom for pe .
clinicians often take solace in clinical decision rules in patients without any clear risk factors .
we present a case report on a patient with abdominal pain who was ultimately diagnosed with a large pe .
the diagnostic consi... | abdominal pain is an uncommon presenting symptom for pulmonary embolism ( pe ) .
a delay in the diagnosis when a patient presents with atypical symptoms can postpone proper treatment and can be catastrophic .
we report the case of a 48-year - old male who presented to the emergency department with worsening right u... |
our laboratories have been investigating the consequences of chemotherapeutic agents on cell surface expression of immunologically important molecules , including major histocompatibility complex ( mhc ) encoded molecules ( both mhc class i and ii ) , b7.1 ( cd80 ) , b7.2 ( cd86 ) , fas ( cd95 ) , and fas ligand ( cd95... | a widely held view is that oncolytic agents induce death of tumor cells directly . in this report
we review and discuss the apoptosis - inducing effects of chemotherapeutics , the effects of chemotherapeutics on metabolic function , and the consequent effects of metabolic function on immune recognition .
finally , ... |
the pectoralis major myocutaneous ( pmmc ) flap is a standard reconstructive technique in patients with cancers in the neck and face and is able to cover major anatomical defects arising from of such radical cancer surgery . in general , transferred flap tissue
the recurrence of the originally resected tumor or the d... | for head and neck as well as for oromaxillofacial surgery , the use of the pectoralis major myocutaneous ( pmmc ) flap is a standard reconstructive technique after radical surgery for cancers in this region .
we report to our knowledge for the first development of breast cancer in the pmmc flap in a 79 year old patie... |
liver biopsy with subsequent histological scoring is the best measure of fibrosis ; and , in patients with chronic hepatitis c ( chc ) , it provides important information relevant to treatment decisions.16 fibrosis assessment can also determine whether the presence of significant fibrosis / cirrhosis warrants additiona... | background : evaluation of advanced fibrosis in patients with hepatitis c virus ( hcv ) infection is used to facilitate decisions on treatment strategy and to initiate additional screening measures .
unfortunately , most studies have predominately caucasian ( cau ) patients and may not be as relevant for african amer... |
a surprising finding in human transcriptome analysis is that protein - coding sequences only account for a small portion of the genome transcripts ( 1 ) .
the majority of the human genome transcripts are non - coding rnas , in particular , long - non - coding rnas ( lncrnas ) ( 2 ) .
normally , lncrnas tend to be l... | in this article , we describe a long - non - coding rna ( lncrna ) and disease association database ( lncrnadisease ) , which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease . in recent years
, a large number of lncrnas have been identified and increasing evidence shows that lncrnas play critical role... |
clear cell odontogenic carcinoma is a rare odontogenic tumor arising from anterior region of mandible and has predilection for females .
it is a potentially aggressive tumor which is capable of frequent recurrences and locoregional and distant metastases . here ,
we present a case of ccoc in a 64-year - old male pa... | clear cell odontogenic carcinoma ( ccoc ) is a rare , potentially aggressive odontogenic epithelial tumor with tendency for recurrence .
it was first described as a clinicopathological entity in 1985 and to date only 73 cases has been reported in english literature . a case of ccoc in 64-year - old male patient in ma... |
it is also called benign mixed tumor of skin as it contains both epithelial and mesenchymal components .
the most common presentation is a small , slow - growing , subcutaneous nodular mass in the head - neck region . until now , only few cases of cytological diagnosis of chondroid syringoma have been reported . here... | chondroid syringoma is a rare benign adnexal tumor of sweat glands with microscopic resemblance to the salivary gland pleomorphic adenoma .
cytology is rarely utilized for preoperative assessment of these slow - growing , small , nodular lesions .
definitive cytological diagnosis is also quite difficult , and major... |
human reaction time ( hrt ) is the amount of time elapsed between the application of a stimulus and a person 's response to it .
hrt is an important indicator of our information processing speed and the appropriate motor response .
quick physical reaction to an external stimulus , or short hrt , can also be conside... | the design and implementation of a wearable system to estimate the human reaction time ( hrt ) to visual stimulus based on two identical wireless motion sensors are described .
each sensor incorporates a motion sensor ( gyroscope ) , a processor and a transceiver operating at the industrial , scientific and medical f... |
in 1977 caspar5 ) and yasargil20 ) introduced an interlaminar approach with partial resection of bony structures and the ligamentum flavum followed by the removal of the intervertebral disc materials6 ) .
since then , various techniques have been developed for the treatment of lumbar disc herniation ( ldh ) , but mos... | objectivethis retrospective study aimed to compare clinical outcomes in terms of pain relief and recurrence rate between fragmentectomies and conventional microdiscectomies in patients with lumbar disc herniation ( ldh).methodsbetween january 2008 and may 2011 , a total of 175 patients met the inclusion criteria of thi... |
kern singh receives royalties from thieme medical publishers , lippincott publishing , stryker , and zimmer ; consults for globus and depuy ; and is on an advisory board for vital 5 and avaz surgical .
sheeraz qureshi is a consultant to medtronic and stryker ; on a scientific advisory board for zimmer and orthofix ; ... | morgan lorio , md , facs , chair , isass task force on coding & reimbursementin 2011 , cpt code 22551 was revised to combine or bundle cpt codes 63075 and 22554 when both procedures were performed at the same site / same surgical session .
the add on code + 22552 is used to report each additional interspace .
2014 ... |
approximately 30 to 48% of adults complain of insomnia symptoms and 10% have symptoms significant enough to meet the diagnostic criteria of insomnia syndrome .
insomnia is characterized by an inability either to fall asleep and/or to maintain sleep throughout the night and/or a waking time earlier than desired .
... | cortical hyperarousal is higher in insomnia sufferers ( ins ) than in good sleepers ( gs ) and could be related to an alteration in sleep protection mechanisms , like reduced density or altered characteristics in sleep spindles .
the deficient sleep protection mechanisms might in turn enhance underestimation of sleep... |
cancer is the second leading cause of death in the usa.1 it is estimated that 1,658,370 new cases of cancer will be diagnosed in the usa and 589,430 individuals will die from cancer in 2015.2 the number of people living beyond a cancer diagnosis will reach 19 million in 2024.3 to determine the risk factors of cancer de... | a multicenter , web - based thyroid cancer and tumor collaborative registry ( tccr , http://tccr.unmc.edu ) allows for the collection and management of various data on thyroid cancer ( tc ) and thyroid nodule ( tn ) patients .
the tccr is coupled with openspecimen , an open - source biobank management system , to ann... |
a total of 144 excisional skin - biopsy specimens were obtained from patients with clinically suspect lesions at therapeutic centers of excellence for buruli ulcer disease in three highly disease - endemic districts in ghana .
specimens were fixed in formalin and transported to the infectious disease pathology activi... | because of the emergence of buruli ulcer disease , the world health organization launched a global buruli ulcer initiative in 1998
. this indolent skin infection is caused by mycobacterium ulcerans . during a study of risk factors for the disease in ghana
, adequate excisional skin - biopsy specimens were obtained ... |
malignant phyllodes tumor ( pt ) is a rare fibro epithelial neoplasm of the breast , which is poor prognosis due to high risk of recurrence and distant metastasis .
we report a case of malignant pt . it had recurred locally five times , and the sixth relapse was occurred 54 months after first diagnosis , presenting a... | abstractbackground : malignant phyllodes tumor ( pt ) is a rare fibro epithelial neoplasm of the breast , which is poor prognosis due to high risk of recurrence and distant metastasis.methods:we report a case of malignant pt . it had recurred locally five times , and the sixth relapse was occurred 54 months after first... |
survival of individuals infected with hiv1 has been dramatically improved since the introduction of highly active antiretroviral therapy ( haart ) , but this increased survival has been associated with the development of chronic disorders .
one example is the early development of emphysema in hiv1 smokers , with a gr... | rationale .
matrix metalloproteinase-9 ( mmp-9 ) expression is upregulated in alveolar macrophages ( am ) of hiv1 + smokers who develop emphysema . knowing that lung epithelial lining fluid ( elf ) of hiv1 + smokers contains increased levels of inflammatory cytokines compared to hiv1 smokers
, we hypothesized that ... |
gestational diabetes mellitus ( gdm ) is defined as any glucose intolerance that occurred or is diagnosed for the first time during pregnancy .
the incidence of gdm has doubled over the last 68 years and is paralleling the obesity epidemic .
gdm carries long - term implications for the subsequent development of typ... | background : a recent study reported a positive association between elevated serum levels of angiopoietin - like protein 2 ( angptl2 ) and the development of type 2 diabetes in a general population .
however , the relationship of serum angptl2 levels with the risk of developing gestational diabetes mellitus ( gdm ) h... |
synovial sarcomas are uncommon tumors that occur predominantly in the extremities , where they tend to arise in the vicinity of large joints , especially the knee region .
primary synovial sarcoma arising in the lung is very rare compared to metastatic sarcoma and sarcomatoid carcinoma , accounting for less than 0.5%... | synovial sarcoma is highly malignant tumor of soft tissues , occurring chiefly in the extremities and limb girdle with a propensity for local recurrence and sometimes metastases to the lungs .
primary synovial sarcoma arising in the lungs is rare and brain metastasis as presentation is further uncommon .
we report ... |
neurofibromatosis type 1 ( nf1 ) is an autosomal dominant disease caused by mutations in the tumor suppressor gene nf1 , which results in increased cellular proliferation and leads to tumor formation .
there are a number of ocular manifestations associated with nf1 , including iris lisch nodules , optic nerve gliomas... | we report the case of a 29-year - old female patient who presented with an acute onset of anisocoria , blurred vision , nausea and severe left - sided headache .
there was no history of trauma , drug abuse , or instillation of topical mydriatic compounds .
the ocular history was negative for similar events . on pre... |
endodontic retreatment has to be done completely after ineffective root canal treatment in order to facilitate the proper chemomechanical preparation of the root canal system and to preserve tooth integrity .
endodontic instruments are used with light or medium pressure in apical way during retreatment that necrotic ... | objective : the goal of present study was to determine the effect of different nickel
titanium file systems on the amount of apically extruded debris during endodontic retreatment : d - race retreatment systems , edgefile xr retreatment rotary files , and reciproc r40.materials and methods : thirty - six single - roo... |
dry eye syndrome is a disorder of the ocular surface that is characterized by loss of natural function of the corneal and conjunctival epithelial barrier . moreover ,
cytomorphological studies have revealed microchanges in the epithelium comprising changes in size of surface cells and number of goblet cells as well a... | summarybackgrounda large number of artificial tears is widely used to treat dry eye symptoms . to test the efficacy of these drugs independent of individual parameters in vitro models are required . as described previously , we employed a reproducible in vitro cell culture system to evaluate the desiccation protection ... |
alzheimer s disease ( ad ) is a neurodegenerative disorder which is one of the main causes of dementia worldwide .
it gradually affects all fields of cognition , including short and long - term memory , executional capacity and behavior . unfortunately , despite advanced and intense research , no definitive therapy i... | aim : to present , through a thorough literature research , current and older scientific efforts to investigate the putative association between alzheimer s disease ( ad ) and glaucoma , especially primary open - angle glaucoma ( poag).methods : we included in our review article epidemiological , experimental and clini... |
these include classical ewing sarcoma of bone , extraskeletal ewing sarcoma , askin 's tumor of the thoracic wall , and peripheral primitive neuroectodermal tumor .
askin 's tumor is a peripheral primitive neuroectodermal tumor of the thoracopulmonary region involving the chest wall .
considering its rarity , we ... | askin 's tumor is a rare tumor arising from the chest wall .
it is a subset of ewing sarcoma characterized histologically by the presence of small round blue cells .
it is a highly malignant tumor with guarded prognosis , which is dependent upon the extension of tumor at the time of diagnosis .
a dual paper of as... |
it has speedily replaced cervical cancer as the most common cancer among indian women . according to figures from the national cancer registry , one in every 25 indian women is likely to suffer from breast cancer at some point of time .
fine needle aspiration ( fna ) cytology has become widely accepted as a reliable ... | introduction . according to the national cancer institute ( nci ) guidelines in 1996 ,
breast lesions are categorized as c1 to c5 on fine needle aspiration ( fna ) cytology .
very few studies are available in the english literature analyzing histopathology outcome of c3 ( atypical , probably benign ) and c4 ( suspi... |
cardiovascular events are still the leading cause of death worldwide and remain one of the main causes of death in modern society .
multiple factors such as thrombolysis or coronary bypass surgery can cause myocardial ischemia - reperfusion ( mi / r ) damage .
the most dangerous effector phase of mi / r can be obse... | backgroundmyocardial ischemia and reperfusion lead to impairment of electrolyte balance and , eventually , lethal arrhythmias .
the aim of this study was to investigate the effects of pharmacological inhibition of angiotensin - ii ( ang - ii ) production on heart tissue with ischemia - reperfusion damage , arrhythmia... |
hla peptide tetrameric complexes were synthesized as previously described ( 17 ) . in brief ,
purified hla heavy chain and 2 microglobulin were synthesized using a prokaryotic expression system ( pet ; novagen , milwaukee , wi ) . the heavy chain was modified by deletion of the transmembrane / cytosolic tail an... | vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes . using tetrameric complexes of human histocompatibility leukocyte antigen ( hla ) class i to identify antigen - specific t cells ex vivo , we observed high frequencies of circulating melana - specific , a*0201-restricted cytotoxic t l... |
a database of refunded prescriptions created by the national health fund in 2008 in poland provided an opportunity to monitor and analyze mortality rates in users of typical and atypical antipsychotics.the lowest mortality was documented in patients treated exclusively with atypical antipsychotics compared with users o... | backgroundthe role of antipsychotics in influencing mortality of patients with mental disorders is still unexplained.objectivethe aim of this study was to determine mortality rates of patients treated with atypical and typical antipsychotics and to compare these data with the mortality rates for the general population.... |
acetabular bone loss is one of the main problems in revision total hip arthroplasty.1 treatment of type i and ii dantonio et al .
deficiency1 with impacted cancellous morselized bone has been shown to provide good results.2 however , the treatment of severe type iii and iv defects is more challenging .
a valuable o... | backgroundthis is a cohort trial ( 19972005 ) of 49 patients submitted to an acetabular component revision of a total hip arthroplasty , using impacted human and bovine freeze - dried cancellous bone grafts ( h&fdbg ) and a reinforcement device.objectiveto compare clinical / radiographic graft incorporation capability ... |
the biochemical function of a protein with known 3d structure can be elucidated by searching for proteins with similar folding patterns and known functions .
however , similar folding alone is not a guarantee of similar biochemical function and conversely , the same biochemical function can be performed by differentl... | a web server , probis , freely available at http://probis.cmm.ki.si , is presented .
this provides access to the program probis ( protein binding sites ) , which detects protein binding sites based on local structural alignments .
detailed instructions and user guidelines for use of probis are available at the serv... |
leishmaniasis is a vector - borne disease caused by an intracellular protozoan parasite species belonging to the genus leishmania ( l. ) .
the disease can present in 3 main forms , comprising visceral leishmaniasis ( vl , often known as kala - azar ) , cutaneous leishmaniasis ( cl ) , and mucocutaneous leishmaniasis ... | background : cutaneous and visceral leishmaniases are present in fars province in the south of iran .
the current study aimed to evaluate the inter- and intragenic diversities of leishmania species isolated from patients with leishmaniasis in fars province , using pcr - based analyses and dna sequencing of the n - ac... |
in the recent years gd - enhanced mri has been the accepted way to go for contrast - enhanced ( ce ) imaging in patients with renal insufficiency to avoid the use of iodinated contrast media ( cm)as for ct . for the same patients group ,
ce - mra replaced diagnostic dsa mainly due to its favourable renal profile and ... | to date there are potential chronology - based but not conclusive reasons to believe that at least some of the gadolinium complexes play a causative role in the pathophysiology of nephrogenic systemic fibrosis ( nsf ) or nephrogenic fibrosing dermopathy ( nfd ) .
still , the exact pathogenesis and the risk for patien... |
using a knotless net , collect individual fish from their holding tank . minimize capture time , avoid collecting multiple fish and do not hold fish for more than a few seconds in the net as these factors can increase stress .
place fish either in a transfer tank with anesthesia or directly to the swim tunnel respiro... | swimming performance tests of fish have been integral to studies of muscle energetics , swimming mechanics , gas exchange , cardiac physiology , disease , pollution , hypoxia and temperature .
this paper describes a flexible protocol to assess fish swimming performance using equipment in which water velocity can be c... |
integrated nano biosystems are expected to offer applications in multiple technologies , such as biodetection and sensing [ 1 , 2 ] , biomedical diagnostics , single molecule dynamics , and photovoltaics . in this work ,
the fundamental properties of such multifunctional hybrid nano biosystems involving core - shell ... | an energy transfer relationship between core - shell cdse / zns quantum dots ( qds ) and the optical protein bacteriorhodopsin ( br ) is shown , demonstrating a distance - dependent energy transfer with 88.2% and 51.1% of the qd energy being transferred to the br monomer at separation distances of 3.5 nm and 8.5 nm ,... |
it is a multifactorial disease that can be effectively treated using lifestyle interventions and/or pharmacotherapy .
recent trends indicate that , despite improved detection and treatments , rates of hypertension are not decreasing in canada . to reverse this trend
, we need to improve our understanding of hyperte... | background . studies assessing the association between psychological factors and hypertension have been equivocal , which may reflect limitations in the assessment of psychological factors . purpose . to assess the relationship between mood and anxiety disorders , measured using a psychiatric interview , and 1-year inc... |
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