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gastric cancer is the second most frequent cause of cancer - related death worldwide and the prognosis remains gloomy because of its high recurrence and metastasis .
immunocytes have long been recognized as a factor promoting antitumor immunity , but recent study shows that it also participates in the formation of tu... | newly identified nuocytes or group 2 innate lymphoid cells ( ilc2s ) play an important role in th2 cell mediated immunity such as protective immune responses to helminth parasites , allergic asthma , and chronic rhinosinusitis .
however , the contributions of ilc2s in the occurrence and development of cancer remain u... |
acute subdural hematomas ( asdh ) are observed in one third of patients with severe traumatic brain injury.22 ) asdh forms between the dura and arachnoid membranes usually due to tearing of bridging veins or arterial rupture .
two most frequent surgical modalities are craniotomy ( co ) and decompressive craniectomy (... | objectivecraniotomy ( co ) and decompressive craniectomy ( dc ) are two main surgical options for acute subdural hematomas ( asdh ) .
however , optimal selection of surgical modality is unclear and decision may vary with surgeon 's experience . to clarify this point , we analyzed preoperative findings and surgical ou... |
dourine is caused by trypanosoma equiperdum of the subgenus trypanozoon . unlike other trypanosomes , dourine is transmitted through coitus with an infected horse rather than insect vectors ( brun et al . , 1998 ) .
thus , dourine has been found to be distributed worldwide , beyond the tsetse belt in sub - saharan a... | dourine is caused by trypanosoma equiperdum via coitus with an infected horse .
although dourine is distributed in equidae worldwide and is listed as an internationally important animal disease by the world organization for animal health ( oie ) , no effective treatment strategies have been established . in addition ... |
mutations in the nuclear gene encoding the catalytic subunit of mtdna polymerase gamma ( polg1 ) are associated with mitochondrial diseases .
polg1 mutations have been implicated in progressive external ophthalmoplegia , sensory ataxic neuropathy , parkinsonism , premature menopause , alpers ' syndrome [ 5 , 6 ] , an... | mutations in the gene encoding of the catalytic subunit of mtdna polymerase gamma ( polg1 ) can cause typical alpers ' syndrome .
recently , a new polg1 mutation phenotype was described , the so - called juvenile - onset alpers ' syndrome .
this polg1 mutation phenotype is characterized by refractory epilepsy with ... |
spondylar and nasal changes , with striations of the metaphyses ( sponastrime ) dysplasia ( sd ) is an acronym first used by fanconi et al to describe the primary features of a new autosomal recessive syndrome of skeletal dysplasia .
the most striking features of this rare genetic disorder are as follows : a moderate... | abstractspondylar and nasal changes , with striations of the metaphyses ( sponastrime ) dysplasia ( sd ) is a dwarfing autosomal recessive syndrome , characterized by a variety of clinical and radiographic features , which form the basis for diagnosis . we describe the presentation of an arnold chiari malformation in a... |
melanoma ( from greek melas : dark ) is a tumor originated from malignant transformation of melanocytes ( i.e. , melanin pigment - producing cells ) that can be found in the skin , bowel , and eye . according to the estimations provided by the american cancer society ( acs ) in 2010 ,
68.130 new cases of melanom... | nowadays , oncogene - directed therapy and immunotherapy represent the two most promising avenues for patients with metastatic melanoma .
the recent oncogene - directed therapeutic , vemurafenib , usually produces high level of tumor shrinkage and survival benefits in many patients with b - rafv600e mutant melanomas ... |
in their doubly deprotonated
form , bis(arylcarboxamido)pyridines 1 have been used
as ligands to support nickel and copper complexes that exhibit novel
properties . a unique anionic copper(ii)superoxide complex
supported by 1 ( r = ipr ) acts as a nucleophile , in contrast to other such species supported
by n... | the synthesis of a series of asymmetric
mixed 2,6-disubstituted ( arylcarboxamido)(arylimino)pyridine
ligands and their coordination chemistry toward a series of divalent
first - row transition metals ( cu , co , and zn ) have been explored .
complexes
featuring both anionic n , n,n-carboxamido and neutral o ... |
department of health and human services office on minority health estimated that , in 2012 , african americans , including those of more than one race , comprised 15.2% of the total u.s . population .
the african american community bears a disproportionally high burden of major nutrition - related chronic diseases [ ... | purpose .
the i am woman ( iaw ) program is a community - based , culturally responsive , and gender - specific nutrition , obesity , and diabetes educational prevention program designed for african american women ( aaw ) .
chronic nutrition - related health conditions such as excess body weight , diabetes mellitus... |
after the november 2014 report of h5n2 hpai outbreaks among poultry in british columbia , the us departments of agriculture and interior , together with state agency personnel , increased surveillance of poultry flocks , hunter - harvested wild birds , and wild bird die - offs along the us canada border .
a wild bir... | novel eurasian lineage avian influenza a(h5n8 ) virus has spread rapidly and globally since january 2014 . in december 2014 , h5n8 and reassortant h5n2 viruses
were detected in wild birds in washington , usa , and subsequently in backyard birds .
when they infect commercial poultry , these highly pathogenic viruses... |
the use of emerging technologies such as smartphones and tablets offers researchers and coaches opportunities to undertake physical performance assessments in the field , rather than the sports science laboratory .
current smartphone technology includes advanced computing capacity , inertial sensors , a global positi... | recent innovations in smartphone technology have led to the development of a number of applications for the valid and reliable measurement of physical performance .
smartphone applications offer a number of advantages over laboratory based testing including cost , portability , and absence of postprocessing .
howev... |
tumours were initiated by intratracheal infection of mice with a lentiviral vector expressing cre - recombinase10 .
cell lines were created by enzymatic and mechanical dissociation of individual lung tumours and metastases harvested from mice 8 - 14 months after tumour initiation .
rna was extracted using trizol , ... | despite the high prevalence and poor outcome of patients with metastatic lung cancer , the mechanisms of tumour progression and metastasis remain largely uncharacterized .
we modelled human lung adenocarcinoma , which frequently harbours activating point mutations in kras1 and inactivation of the p53-pathway2 , using... |
coronary artery disease ( cad ) is the leading cause of death in this world . in the united states alone , 785000 people have a new coronary event each year with an estimated direct and indirect cost of $ 110 billion.1)2 ) regrettably , the initial diagnosis of cad often occurs only after an event yields significant di... | coronary artery disease ( cad ) remains the leading cause of death and morbidity worldwide . to date , diagnostic evaluation of patients with suspected cad has relied upon the use of physiologic non - invasive testing by stress electrocardiography , echocardiography , myocardial perfusion imaging ( mpi ) and magnetic r... |
science is a powerful collective social endeavor that systematizes knowledge by providing testable explanations , making predictions , and solving or controlling problems for the betterment of our world . because of its impact , the implications of scientific progress are huge for the future of mankind and our planet .... | abstractin a recent opinion paper , b.k .
shanta claims science leaves no room for the subjective aspect of consciousness , and in doing so , attacks both origin of life and evolutionary research .
he claims vdanta , one of the 6 orthodox schools of hindu philosophy , offers an explanation : the origin of everythi... |
microsatellite loci were isolated from the recently published c. calcarata genome ( rehan et al . 2016 ) using the microsatellite identification tool ( misa ; thiel et al .
2003 ) interfaced with an executable version of primer 3 ( koressaar and remm 2007 ; untergasser et al .
misa was used to trim genomic reads to... | the small carpenter bee , ceratina calcarata ( robertson ) , is a widespread native pollinator across eastern north america .
the behavioral ecology and nesting biology of c. calcarata has been relatively well - studied and the species is emerging as a model organism for both native pollinator and social evolution re... |
physical and occupational therapies are clinical sciences playing an important role in the
practice of rehabilitation medicine and services .
they are also evidence - based academic
methods used in clinical environments , and clinical studies and techniques addressing
disabilities through practical activities .... | [ purpose ] this study examined the effects of clinical training focusing on level-3 osce
( analytical and therapeutic skills ) items , and compared the achievement levels of physical
( pt ) and occupational ( ot ) therapist students . [ subjects ] a total of 282 ( 165 pt and 117
ot ) students enrolled at our uni... |
the traditional route of infection is by ingesting raw or improperly cooked pork from infected domestic swine .
eight species and three genotypic variants have been identified in various animal hosts ( 1 ) , and trichinella spiralis is the most common cause of human trichinellosis ( 2 ) .
there have been reports of... | the clinical diagnosis of trichinellosis can be difficult due to lack of pathognomonic signs or symptoms .
in korea , since the first report of human infection by trichinella spiralis in 1997 following the consumption of raw badger meat , there have been occasional trichinellosis outbreaks .
we describe an outbreak... |
restoration of accommodation in pseudophakic patients is a major goal of modern cataract surgery . so far a variety of devices and surgical techniques have been introduced to solve the problem of presbyopia correction and to provide satisfactory distance and near vision without spectacles after cataract surgery .
an ... | purpose . to evaluate the predictability of lens shift induced by pilocarpine ( lspilo ) on the outcomes of accommodating intraocular lens ( acc - iol ) implantation .
methods .
twenty - four eyes of 24 senile cataract patients who underwent phacoemulsification and acc - iol implantation were enrolled .
lspilo wa... |
brain metastases are the most common intracranial tumors in adults , accounting for over half of all lesions ( 1,2 ) . whole - brain radiation therapy ( wbrt )
has been a cornerstone in the management for brain metastases for decades ( 36 ) .
modern surgical techniques that minimize surgical morbidity and mortality... | brain metastases are the most common intracranial tumors in adults , accounting for over half of all lesions .
whole - brain radiation therapy ( wbrt ) has been a cornerstone in the management of brain metastases for decades .
recently , stereotactic radiosurgery ( srs ) has been considered as a definitive or posto... |
overweight and obesity is a major public health problem worldwide . for example , the world health organization reported that the global prevalence of overweight and obesity in adults , defined as a body mass index ( bmi ) 25 kg / m , is approximately 2 billion , and by the year 2015 , will increase to approximately 3... | this study used the aggregate data meta - analytic approach to determine the combined effects of aerobic exercise and diet on lipids and lipoproteins in overweight and obese adults .
twelve studies representing 859 men and women ( 443 intervention , 416 control ) were included . using random - effects models , statis... |
gangliosides are well recognized mediators of certain essential signaling pathways in the nervous system and other organs , and a growing number of proteins involved in such pathways are seen to function in association with one or another ganglioside .
considerable insight into ganglioside - protein interactions has ... | parkinson s disease ( pd ) is the second most prevalent late - onset neurodegenerative disorder that affects nearly 1% of the global population aged 65 and older .
whereas palliative treatments are in use , the goal of blocking progression of motor and cognitive disability remains unfulfilled .
a better understandi... |
type 2 diabetes mellitus ( t2 dm ) results from an interaction of environmental and genetic factors . despite the initial enthusiasm from the identification of risk loci for t2 dm [ 1 , 2 ] , the clinical utility of these genetic markers for t2 dm risk prediction and reduction has remained limited .
it is becoming in... | the aim of this study is to quantify global dna methylation and investigate the relationship with diabetes status and polymorphisms in mthfr c677 t and nos3 g894 t genes in mixed ancestry subjects from south africa .
global dna methylation was measured , and mthfr rs1801133 and nos3 rs1799983 polymorphisms were genot... |
staphylococcus aureus is a major human pathogen that causes skin and soft - tissue infections , life - threatening infections such as pneumonia and sepsis , and toxinoses including toxic shock syndrome .
methicillin - susceptible s. aureus ( mssa ) has evolved as methicillin - resistant s. aureus ( mrsa ) through t... | the pathogenesis of community - associated methicillin - resistant staphylococcus aureus ( ca - mrsa ) pneumonia in influenza - infected elderly individuals has not yet been elucidated in detail . in the present study , a 92-year - old man infected with influenza developed ca - mrsa pneumonia .
his ca - mrsa was an e... |
the pentylenetetrazole ( ptz)- kindling model is a suitable model to show post abnormality of seizure and can be used to find useful treatments for cognitive impairment in human epilepsy ( 2 ) .
memory impairment has been reported in patients with temporal lobe epilepsy ( tle ) ( 3 ) .
several studies showed that c... | backgroundin humans , convulsive diseases such as temporal lobe epilepsy are usually accompanied by learning and memory impairments . in recent years , the role of gap junction channels as an important target of antiepileptic drugs has been studied and discussed .
quinine , as a gap junction blocker of connexin 36 , ... |
air pollution is known to have detrimental effects on health as demonstrated in numerous studies [ 1 , 2 ] .
a number of health impact assessments ( hia ) have been made to quantify the impact from various components of air pollution and in a number of different geographical settings [ 36 ] .
most focused on the ef... | objective . to explore how three different assumptions on demographics affect the health impact of danish emitted air pollution in denmark from 2005 to 2030 , with health impact modeled from 2005 to 2050
. methods . modeled air pollution from danish sources was used as exposure in a newly developed health impact asse... |
a 45-year - old male complaining of chronic cough and sputum was referred to our hospital in october , 2010 .
chest computed tomography ( ct ) scan demonstrated a left lower lobe mass of the lung ( fig .
percutaneous transthoracic needle biopsy was performed on the left lower lobe mass of the lung .
histological ... | metastases of malignant tumors to the oral region from distant sites are uncommon .
a 45-year - old man with painless gingival swelling was diagnosed with adenocarcinoma of the lung . on cytology ,
clusters of tumor cells on mucous background revealed enlarged nuclei , indistinct cell borders , and irregular nuclea... |
a 50-year - old man was referred to us due to decreased visual acuity in both eyes . the patient had spondylolisthesis and had undergone a lumbar laminectomy three months prior to these symptoms .
after the operation , he had been bed - ridden in the supine position . the day before the visit
, the patient had sat ... | a 50-year - old man had undergone lumbar vertebral surgery and was confined to bed in the supine position for three months .
when he sat up from the prolonged supine position , he showed clinical signs of orthostatic hypotension and reported decreased vision in both eyes .
he also had underlying anemia .
ophthalm... |
breast cancer represents the second cause of cancer mortality in women , after lung cancer .
mammography is the gold standard imaging modality for the detection and characterization of breast tumours .
other imaging techniques used in conjunction with mammography and physical examination are mainly ultrasonography ... | the purpose of this prospective study is to determine the diagnostic accuracy of near - infrared breast optical absorption imaging in patients with breast imaging reporting and data system ( birads ) 45 non - palpable lesions scheduled for biopsy , using pathology after core or excisional biopsy as a reference .
the ... |
intraradicular posts are commonly used to restore endodontically treated teeth when their remaining coronal structure can not provide adequate support and retention for the restorative material . cast post and
however , demands for simpler procedures and esthetic restorations led to the development of prefabricated p... | purpose : to evaluate the fracture strength of endodontically treated teeth with reduced coronal structure reinforced with glass - fiber posts and cast posts and core ( nickel chromium alloy ) with different thickness.materials and methods : forty maxillary central incisors were sectioned at 1 mm of the cementoenamel ... |
the ige - mediated allergic reactions to food are caused , generally , by ingestion .
however , they can be rarely induced by exposure to airborne food particles through the handling or the cooking .
vicia faba is a vegetable which belongs to legumes or fabaceae family , fabales order .
the name legume or po... | the ige - mediated allergic reactions to food are caused , generally , by ingestion .
however , they can be rarely induced by exposure to airborne food particles through the handling or the cooking .
vicia faba is a vegetable which belongs to legumes or fabaceae family , fabales order .
allergic reactions after i... |
ventilator - associated pneumonia ( vap ) is one of the most common nosocomial infections among intensive care unit patients , which prolongs ventilation and hospitalization , resulting in significant morbidity , mortality and medical costs.13 researchers have developed strategies to prevent vap , including controlling... | purpose : ventilator - associated pneumonia ( vap ) is a nosocomial infection resulting in significant morbidity and mortality .
pseudomonas aeruginosa ( p. aeruginosa ) and staphylococcus aureus ( s. aureus ) are pathogens associated with vap .
silver ( ag ) coating of endotracheal tubes ( etts ) reduces bacterial... |
tacrolimus , a calcineurin inhibitor , remains the centerpiece of the maintenance treatment scheme in renal transplant recipients .
both its narrow therapeutic index and its highly pharmacokinetic variance may lead to overtreatment and toxicity or insufficient treatment and transplant rejection , conditions that are ... | background : the aim of our study was to determine the impact of cyp3a5 * 1 and cyp3a5 * 3 on the kinetics of tacrolimus in renal transplant recipients.material and methods : forty kidney recipients were selected to participate .
maintenance scheme consisted of tacrolimus , a purine inhibitor and a steroid .
cyp3a5... |
mass deaths occurred at a large rearing facility for north american bullfrogs ( rana catesbeiana ) , 46 km from montevideo , uruguay .
the farm is a commercially managed operation , with trained employees under permanent , technical supervision .
mortality rates during the days before the outbreak were approximatel... | chytridiomycosis is an emerging disease responsible for global decline and extinction of amphibians .
we report the causative agent , batrachochytrium dendrobatidis , in north american bullfrogs ( rana catesbeiana ) farmed for the international restaurant trade .
our findings suggest that international trade may pl... |
asthma is common and increasing in prevalence , with an estimated 300 million sufferers worldwide .
severe asthma represents 5%10% of asthma sufferers and is of particular importance as in this group there is greater morbidity and mortality and an increased burden upon health care resources .
likewise , obe... | background .
asthma and obesity are common ; however the impact of obesity upon asthma remains uncertain .
objectives . to assess relationships between obesity and fat mass with airway inflammation , lung function , and disease control in patients with refractory asthma . methods .
151 refractory asthma patients ... |
schizophrenia is a chronic disease characterized by diverse and varied picture of the clinical course .
it is undoubtedly the most serious and most debilitating mental illness , which is one of the first ten causes of disability among the young and the elderly .
the risk over a lifetime reaches 1% regardless of geo... | schizophrenia is the most severe and most debilitating mental illness , which is one of the first ten causes of disability in youth and elderly people . regarding many consequences that schizophrenia brings for individual and social functioning of ill people , their assessment of the quality of their lives seems to be ... |
restoration of independent and functional ambulation is a major rehabilitation goal for patients with hemiparesis .
although the majority of these patients achieve some degree of independent gait , many do not reach a walking level that enables them to perform activities of daily living.1,2 the inability to resume co... | backgroundfunctional electrical stimulation ( fes ) is becoming an accepted treatment method for enhancing gait performance in patients who present with gait difficulties resulting from hemiparesis .
the purpose of this study was to test whether individuals with hemiparesis who have varied gait speeds , which place t... |
sarcomas are diagnosed as 0.8% of invasive malignancies per annum and cause 2% of cancer deaths .
the cells of origin are varying , so the diagnosis of stt is difficult at times .
fine needle aspiration cytology ( fnac ) has been employed as a useful technique for the initial diagnosis of stt as well for the identi... | background : fine needle aspiration cytology ( fnac ) has been employed as a useful technique for the initial diagnosis of soft tissue tumors ( stt ) as well for the identification of recurrent and metastatic cases.aim:we conducted this study on soft tissue tumors to find the efficacy of fnac and to finalize the histol... |
a 30-year - old caucasian man presented to the pulmonary function laboratory for a pulmonary function test ( pft ) and methacholine challenge test .
measured height and weight on the day of testing indicated a body mass index of 28.1 kg / m .
baseline pft data are summarized in table 1 , the flow - volume loop and ... | methacholine challenge tests only determine airway hyper - responsiveness to a nonspecific agent , and can be associated with relatively low sensitivity and specificity ; therefore , they should not be used in isolation to diagnose asthma . accordingly , alternative adjunctive measures of pulmonary function have been r... |
the main chemical component of human urinary kallidinogenase ( uk ) is tissue kininogenase 1 ( hkl ) . in plasma ,
hk1 catalyzes kininogen hydrolysis into kallidin , which can combine with g protein - coupled receptors ( b1 and b2 receptors ) in endothelial cells .
only the b2 receptor of kinin is found in normal t... | backgroundin this study we investigated the effect of urinary kallidinogenase ( uk ) on transforming growth factor beta 1 ( tgf-1 ) expression in brain tissue .
we also explored the neuroprotective mechanism of uk against ischemic injury by measuring serum high - sensitivity c - reactive protein ( hs - crp ) level ch... |
ebola and marburg are single - stranded rna viruses in the family filoviridae associated with viral hemorrhagic fever outbreaks , mainly in africa . although outbreaks are relatively rare , localized , and small , these diseases garner fear and media attention due to high fatality rates up to 90% and concern over their... | breaking the human - to - human transmission cycle remains the cornerstone of infection control during filoviral ( ebola and marburg ) hemorrhagic fever outbreaks .
this requires effective identification and isolation of cases , timely contact tracing and monitoring , proper usage of barrier personal protection gear ... |
postbariatric surgery poly - neuropathies ( bsp ) are infrequent events . however , with the number of gastric bypasses performed each year increasing , the incidence of bsp is expected to increase as well .
we present the case report of a patient who developed a poly - neuropathy after a laparoscopic roux - en - y g... | background : postbariatric surgery poly - neuropathies ( bsp ) are infrequent events .
however , with the number of gastric bypasses performed each year increasing , the incidence of bsp is expected to increase as well .
the long - term sequelae of bsp worsen with delays in diagnoses . therefore ,
early evaluatio... |
oral malodor is caused mainly by the metabolism of sulfur amino acids by anaerobic bacteria inhabiting the oral cavity .
the main compounds responsible for oral malodor are volatile sulfur compounds ( vscs ) , such as hydrogen sulfide ( h2s ) , methyl mercaptan ( ch3sh ) , and dimethyl sulfide ; these compounds are p... | volatile sulfur compounds ( vscs ) produced by oral anaerobes are the major compounds responsible for oral malodor .
enterococcus faecium wb2000 is recognized as an antiplaque probiotic bacterium . in this study ,
the effect of e. faecium wb2000 on vsc production by porphyromonas gingivalis was evaluated , and the ... |
cutis laxa ( cl ) is a rare connective tissue disorder caused by defects in the elastic fiber network that can affect multiple tissues , predominantly the skin .
redundant skin is often most noticeable on the neck , hands , and groin , but can also be seen on the face , creating a premature aging appearance .
we re... | we describe a case of generalized cutis laxa ( cl ) in a 7-year - old female child . at 2 months of age
, she was found to have a hoarse voice , and at 3 years , she was much smaller than her peers .
her aging face and short stature caught our attention , and the treatment of the patient was accepted by our hospita... |
t - cell large granular lymphocyte ( t - lgl ) leukemia is a disease characterized by clonal proliferation of cytotoxic t cells ( cd8 cells ) .
the etiology of t - cell lgl leukemia has not been entirely elucidated ; however , chronic antigenic stimulation with exogenous antigens such as human t - cell lymphotrophic ... | t - cell large granular lymphocyte ( t - lgl ) leukemia represents a clonal proliferation of cytotoxic t - cells which etiology has not been entirely elucidated .
however , cd4 + , cd4 , cd8 , cd4 + , cd8 + cases have been described .
the disease is usually characterized by cytopenias and a modest lymphocytosis .
... |
peripheral ossifying fibroma ( pof ) is a focal , reactive , sessile or pedunculated , and nonneoplastic smooth surfaced soft tissue tumor that frequently originates in gingiva or interdental papilla of anterior maxilla and may appear ulcerated or erythematous or exhibit no color difference from the adjacent gingiva . ... | peripheral ossifying fibroma ( pof ) is a local gingival reactive lesion , thought to be originating from the superficial periodontal ligament .
it is found most often in the anterior maxilla with predilection for females and high recurrence rate .
clinically , the lesion is observed in gingiva or interdental papil... |
a one - month - old male baby , who had been born at 38 weeks of gestation with a birth weight of 3,700 gm , underwent conventional biventricular repair for congenitally corrected transposition of great arteries , ventricular septal defect ( vsd ) , atrial septal defect ( asd ) , and patent ductus arteriosus ( pda ) . ... | a seventeen - month - old male baby , who had received conventional biventricular repair for congenitally corrected transposition of the great arteries , underwent excision of supratricuspid ring .
although tricuspid valve annulus was marginally small on direct inspection in the operating theater , circumferential ex... |
teratomas are composed of various cell types , which represent more than one germ layer .
sacrococcygeal teratoma is the most common solid neoplasm in neonates , with an estimated prevalence of 1 in 35,000 - 40,000 births .
they can be diagnosed prenatally by fetal ultrasound ; 50 - 70% of cases are found during th... | although the sacrococcygeal area is the most common site for a teratoma in infants , it is a rare site for a teratoma in older patients .
most of the teratomas found in this area in adults are single mass , but in a few cases , multiple masses have been reported .
the author reports on the case of an 18-year - old ... |
osteochondral damage is a frequent consequence of traumatic and degenerative alterations of joints and bones .
as articular cartilage is an avascular tissue in which differentiated cells are embedded in an organic matrix , it has a very limited potential for spontaneous healing [ 2 , 3 ] .
different tissue engineer... | bone and cartilage regeneration can be improved by designing a functionalized biomaterial that includes bioactive drugs in a biocompatible and biodegradable scaffold . based on our previous studies
, we designed a vanadium - loaded collagen scaffold for osteochondral tissue engineering .
collagen - vanadium loaded ... |
hydralazine ( 1-hydrazinophthalazine , 4 , scheme 1 ) is an antihypertensive
agent that was introduced
into the clinic in the early 1950s , and this drug
remains in use , primarily for the treatment of gestational hypertension . in addition , 4 induces demethylation of cellular dna , a property that has given the... | hydralazine
( 4 ) is an antihypertensive agent that
displays both mutagenic and epigenetic properties . here
, gel electrophoretic ,
mass spectroscopic , and chemical kinetics methods were used to provide
evidence that medicinally relevant concentrations of 4 rapidly form covalent adducts with abasic sites in... |
in vitro selection by display methods has been an effective tool in the field of protein engineering and especially has been used to engineer recombinant antibodies for various biological applications .
phage display has been widely used in the industry due to its feasibility to select fab fragments .
the fab fragm... | in vitro selection by display methods has been an effective tool for engineering recombinant antibodies .
mrna display based on a cell - free translation system has the advantages of larger library sizes and quicker selection procedures compared with cell - based display methods such as phage display .
however , mr... |
discoid meniscus is a well - documented knee pathology , and there are many cases of medial or lateral discoid meniscus reported in the literature .
however , ipsilateral concurrent medial and lateral discoid meniscus is very rare , and only a few cases have been reported .
a 27-year - old japanese man complained o... | introduction : discoid meniscus is a well - documented knee pathology , and there are many cases of medial or lateral discoid meniscus reported in the literature .
however , ipsilateral concurrent medial and lateral discoid meniscus is very rare , and only a few cases have been reported . herein , we report a case of... |
still rings true , both in general life and specifically in relation to risk of ocular injury from pens , pencils , or swords . penetrating eye injury
is estimated to have a population incidence of about 1 in 29,000.1 the incidence of eye injury from writing instruments such as pens or pencils is uncertain .
four p... | purposeto consider the potential for ocular injury from writing implements by presenting four such cases , and to consider the incidence of such eye injuries from analysis of a national trauma database.methodsthe home and leisure accident surveillance system was searched for records of eye injuries from writing instrum... |
these are tumours of epidermal origin that can invade and metastasise and which may ultimately prove fatal .
these are tumours , probably of mesenchymal origin that , like carcinomas , are also locally invasive and have the ability to metastasise and again , are also found in humans [ 14 ] . in cats and dogs ,
a va... | the etiology of feline injection - site sarcomas remains obscure .
sarcomas and other tumors are known to be associated with viral infections in humans and other animals , including cats .
however , the available evidence suggests that this is not the case with feline injection - site sarcomas .
these tumors have... |
using electronic databases ( psycinfo , psycarticles , medline ) and article searches ( the latter based on reviews of reference lists ) , all published literature was searched using the terms autism , autistic disorder , high - functioning autism , autistic spectrum disorder , asperger s , asperger s disorder , asperg... | abstractintroductionfor the past two decades , researchers have been using various approaches to investigate the relationship , if any , between autism spectrum disorder ( asd ) and violence .
the need to clarify that relationship was reinforced by the tragic mass shooting at sandy hook elementary school in newtown ,... |
situs solitus represents the normal position of heart and viscera relative to midline , and situs inversus indicates mirror - image location of the viscera relative to situs solitus.1 ) situs ambiguous ( sa ) is defined as an abnormality which can be considered to be present when the thoracic and abdominal organs are n... | situs ambiguous is rare congenital anomaly in adults . in 2 adult patients who admitted for different cardiac problems ,
situs ambiguous with polysplenia was detected .
a 42-year - old male admitted for radio frequent catheter ablation of atrial fibrillation , and he had left - sided inferior vena cava ( ivc ) , he... |
catecholamine syndrome is a frequent factor leading to hypertension , including adrenal medullary hyperplasia ( amh ) and pheochromocytoma .
however , amh is much rarer than pheochromocytoma , which is characterized by paroxysmal hypertension clinically and adrenal medullary cell mass hyperplasia pathologically .
p... | objective . to dissect the characteristics of adrenal medullary hyperplasia ( amh ) and share our experience of diagnosis and treatment of amh
. methods . from 1999 to 2013 , 12 cases of amh have been pathologically diagnosed after operation in our hospital . the clinical characteristics , process of diagnosis , trea... |
copd is characterized by persistent airflow limitation.1,2 inhaled 2-agonists and antimuscarinics have become central to the management of patients with copd , as they improve lung function.2 improvements in exercise tolerance and quality of life , and reductions in copd symptoms including exacerbations have also been ... | categorization of patients with copd as reversible or nonreversible to a bronchodilator may change over time .
this post hoc analysis aimed to determine if an individual s reversibility , when treated as a continuous variable , could predict his / her future response to two short - acting bronchodilators : albuterol ... |
large format sections ( synonym macrosections ) ( ls ) comprise an entire histological section of the organ under study .
ls allow the histological study of a large part of the organ of interest , that include not only the lesions but also the surrounding tissues possibly inclusive of the entire margins at least alon... | large format sections ( ls ) first have been introduced in breast pathology more than a century ago . since then , they constituted for longtime a research tool to better understand breast microanatomy and the relationship between radiological images and pathological features .
similarly ls have been used to study ne... |
a number of bioactive compounds of current interest are discovered by phenotypic screening , most of which are functional in nature through analyzing the compound - induced effects in cells , tissues , and model organisms .
these assays , however , can hardly provide immediate target information for tested compounds ... | molecular target identification is of central importance to drug discovery . here
, we developed a computational approach , named bioactivity profile similarity search ( bass ) , for associating targets to small molecules by using the known target annotations of related compounds from public databases . to evaluate b... |
respiration can be controlled by voluntary and involuntary functions of the nervous system ( 11 ) .
the medulla contains inspiratory and expiratory centers in the ventral respiratory group that coordinate the breathing cycle ( 11 ) . during quiet , or spontaneous breathing ( sb ) , inspiratory and
expiratory neuron... | controlled or paced breathing is often used as a stress reduction technique but the impact on blood pressure ( bp ) and sympathetic outflow have not been consistently reported .
the purpose of this study was to determine whether a controlled breathing ( 12 breaths / min , cb ) rate would be similar to an individual s... |
the studied dairy cafo milks 2,000 + and has close to a total of 4,000 animals , separated into two different locations .
the dairy has expanded , with the herd size doubling several times during the last decade .
a substantial number of new animals were introduced into the herd during the 10% herd expansion throug... | antimicrobial resistance is threatening humans and animals worldwide .
biosecurity and 1-year usage of antibiotics on a dairy concentrated animal feeding operation ( cafo ) in ny state , usa , were mapped : how much antibiotics were used , for what purpose , and whether any decrease could be warranted .
approximate... |
arterial stiffness is a common change associated with aging.28 ) vascular stiffening develops from a complex interplay between stable and dynamic changes involving structural and cellular elements of the vessel wall .
these alterations of arterial stiffening are closely related to a multitude of potentially interacti... | objectivearterial stiffness is a common change associated with aging and can be evaluated by measuring pulse wave velocity ( pwv ) between sites in the arterial tree , with the stiffer artery having the higher pwv .
arterial stiffness is associated with the risk of stroke in the general population and of fatal stroke... |
many definitions have been used to describe anchorage by various authors in orthodontic literature but to summarize the basic meaning of anchorage it may be described as the resistance of an object to an external force acting on it which may be utilized for tooth movement . more often than not the teeth themselves are ... | objective : implants are being used in orthodontics as a reliable mode of anchorage . among other factors , the cortical bone thickness plays a major role in determining the stability of these implants . the objective of this study was to study the relationship of various arch forms and the cortical bone thickness and ... |
annually , over 4 million patients within the 27 european union member states acquire a nosocomial infection , of whom approximately 37 000 will die as a result .
surgical site infections ( ssis ) are the third most common form of healthcare - associated infection ( hai ) , behind urinary tract ( 27% ) and lower res... | summaryover 4 million patients suffer nosocomial infections annually in the european union .
this study aimed to estimate the healthcare burden associated with healthcare - associated infections ( hais ) following surgery in france , and explore the potential impact of infection control strategies and interventions o... |
by definition , ntg differs from poag only in that the iop is consistently less than 21 mmhg .
it has been postulated that poag and ntg represent a continuum of open angle glaucomas on opposite ends of a spectrum , with iop being the primary causative risk factor in the former and iop - independent risk factors being... | glaucoma is a progressive optic neuropathy that causes characteristic changes of the optic nerve and visual field in relation to intraocular pressure ( iop ) .
it is now known that glaucoma can occur at statistically normal iops and prevalence studies have shown that normal tension glaucoma ( ntg ) is more common tha... |
significant advances in surgical technique and perioperative management have dramatically improved the survival of patients with advanced gastric cancer ; nevertheless , peritoneal metastasis is still the most common cause of tumor progression , and the prognosis of those patients with peritoneal recurrence remains ext... | peritoneal metastasis , which often arises in patients with advanced gastric cancer , is well known as a miserable and ill - fated disease .
once peritoneal metastasis is formed , it is extremely difficult to defeat .
we advocated eipl ( extensive intraoperative peritoneal lavage ) as a useful and practical adjuvan... |
increasing incidence of tuberculosis ( tb ) as well as the escalating trend of resistance to anti - tb drugs has attracted much attention during the past decades and has turned out the need for early microbiological confirmation of tb and drug sensitivity testing more than ever . on the other hand ,
approximately 50%... | background : there are number of patients who are unable to expectorate sputum specimens . in this study , we used gastric lavage ( gl ) test for diagnosis of tuberculosis ( tb ) in patients who were unable to produce sputum.materials and methods : patients who were unable to produce sputum specimens were included in t... |
rectal cancer is common and poses much burden worldwide [ 1 , 2 ] . advances in treatment over the past three decades have led to substantially improved local control and survival [ 37 ] .
furthermore , the increasing use of sphincter - preserving resection with a low colorectal or coloanal anastomosis has resulted i... | with enhanced surgical techniques and neoadjuvant therapy in rectal cancer , survivorship issues are at the forefront of clinical practice and research .
more and more patients are living with altered bowel habits following rectal cancer surgery .
sound assessment of anorectal function after rectal cancer surgery i... |
vitamin d is involved in a number of processes that are essential for healthy body functions .
it helps to improve muscle strength and immune function and reduces many of the inflammatory processes within our bodies .
vitamin d is also known to promote the absorption of calcium from the gastrointestinal tract and t... | backgroundthe season of diagnosis of several forms of cancer has been observed to impact survival , supporting the hypothesis that vitamin d3 has a protective role in cancer survival .
all previous studies demonstrating this seasonality were performed in european populations residing at latitudes upwards of 50n .
t... |
prostate cancer ( pc ) is a common malignancy of male urinary system and its incidence varies significantly between ethnic groups and regions worldwide .
the statistics from american association for cancer research showed there were 241,740 new cases of pc and 28,170 patients died of pc in 2012 . among male tumors , ... | abstractthe relationship of oestrogen receptor with benign prostatic hyperplasia ( bph ) and prostate cancer ( pc ) is not clear at present .
this study aimed to investigate the molecular mechanism underlying the occurrence and development of bph and prostate.two hundred forty - four pc cases , 260 bph patients , and... |
tuberculosis ( tb ) is the 7th leading cause of death and disability worldwide and has reached epidemic proportions in both developed and undeveloped nations .
tuberculomas account for 10 to 30% of intracranial ( ic ) masses in tb - endemic areas .
the clinical and neuroimaging features of tuberculoma are variable ... | intracranial brain parenchymal tuberculomas may form paradoxically , days to months after starting antituberculous drug therapy .
they may develop in and around optic chiasm and optic nerves after antituberculous treatment as a quite rare occurrence in tuberculous meningitis ( tbm ) this may lead to severe visual los... |
chronic disease is considered as one of the major problems and issues of health and social care system in current societies .
patients in the last stage of life are patients who are not expected to live more than 6 months based on current medical knowledge . nowadays , paying attention to these patients and their fam... | introduction : in view of the recent surge in chronic disease rates and elderly population in the developing countries , there is an urgent felt need for palliative and hospice care services .
the present study investigates the views and attitudes of patients and their families , physicians , nurses , healthcare admi... |
a micro - array experiment is conducted to study expression profiles of genes in a specimen under different experimental conditions , or over several different time periods .
it serves many purposes that include ( 1 ) developing a predictive computational model which can be used to predict biomarkers and targets for ... | microarray technology provides an opportunity to view transcriptions at genomic level under different conditions controlled by an experiment . from an array experiment using a human cancer cell line that is engineered to differ in expression of tumor antigen , integrin 64 ,
few hundreds of differentially expressed ge... |
treatment - resistant depression ( trd ) is a relatively common condition presenting with substantial challenges to both the clinician and researcher .
in fact , despite a progressively higher number of available antidepressant therapies , trd occurs frequently in clinical practice , and is associated with profound p... | treatment - resistant depression ( trd ) represents a source of ongoing clinical and nosological controversy and confusion .
while no univocal consensus on its definition and specific correlation with major mood disorders has been reached to date , a progressively greater number of evidences tend to suggest a revisio... |
the course of an untreated acute type a aortic dissection has the potential to rapidly progress into a catastrophic state .
the known factors that contribute to increasing the mortality rate include the development of pericardial tamponade from aortic rupture , acute myocardial ischemia or infarction due to involveme... | backgroundtotal arch replacement ( tar ) is being more widely performed due to recent advances in operative techniques and cerebral protective strategies . in this study
, the authors reviewed the relationship between tar and early- and mid - term changes of the false lumen after tar in acute type a aortic dissection... |
bacterial strains , plasmids , and growth conditions the
bacterial strains and plasmids used in this study are listed in
table 1 .
the s.
enterica serovar typhimurium strains were derived from the wild - type
( wt)4 strain
atcc14028s ( 36 ) .
p22-mediated
transductions were performed as described... | salmonella enterica serovar typhimurium has at least nine
multidrug efflux pumps . among these pumps , acrab is effective in generating
drug resistance and has wide substrate specificity . here
we report that
indole , bile , and an escherichia coli conditioned medium induced the
acrab pump in salmonella t... |
we performed a retrospective study of individuals with domestically acquired c. jejuni infection in order to assess factors associated with related hospitalisations in sweden between november 2011 and october 2012 .
a total of 8,585 notifications of cases with laboratory - confirmed campylobacter infection were recei... | backgroundcampylobacter jejuni is among the most frequent causes of bacterial gastroenteritis in europe .
over 8,000 c. jejuni multilocus sequence typing sequence types ( sts ) have been described ; st-21 and st-45 have been identified as the most frequent types in all human studies so far .
in contrast to other st... |
hypoderaeum conoideum is the member of family echinostomatidae that occurs in the posterior part of small intestine of the ducks , geese , swans , wild aquatic birds and human ( 13 ) .
miracidia of h. conoideum develops almost in three weeks in the egg in environment and release in water .
cercaria enters either sa... | background : human echinostomiasis is an intestinal disease caused by the members of family echinostomatidae parasites . the aim of present research was to identify echinostomatidae cercariae emitted by lymnaea palustris snails from mazandaran province in the north of iran based on the morphological and morphometrical ... |
use of dental implants is a widespread treatment modality to restore missing teeth and edentulous cases;[13 ] however , a successful implant treatment depends on the lack of inflammation in peri - implant tissues.[46 ] being exposed to the oral cavity , implant 's surface gets colonized by micro - organisms .
a recen... | background : when an implant is exposed to oral cavity , its surface gets colonized by micro - organisms . the aim of this study is to comparatively assess the microbiological parameters in sulci around the teeth and the crowns supported by dental implants.materials and methods : in this prospective , cross - sectional... |
the past 15 years have
witnessed the development of phosphine ligands used for palladium - catalyzed
cross - couplings with aryl chlorides . among
them
, sterically bulky and electron - rich alkylphosphine ligands have
proved particularly successful and have been widely applied in synthesis .
simple triaryl... | although
the past 15 years have witnessed the development of sterically bulky
and electron - rich alkylphosphine ligands for palladium - catalyzed cross - couplings
with aryl chlorides , examples of palladium catalysts based on either triarylphosphine or bidentate phosphine ligands for efficient room temperature ... |
the first task of public health scholars was to clarify the definition of health system . in the 1990s , the notion of the district health system was seen as pivotal for health sector reform and the modernization of the state , which started in the 1980s .
this decentralization strategy consisted of a transfer of r... | understanding health systems have now become the priority focus of researchers and policy makers , who have progressively moved away from a project - centred perspectives .
the new tendency is to facilitate a convergence between health system developers and disease - specific programme managers in terms of both think... |
penile length in children has rarely been studied , especially in korea . in 1987 , a study of penile length and testicular size was conducted in 1,071 korean children .
penile length was measured by assessing the stretched penile length ( spl ) from the tip of the glans to the base of the penis at its attachment to ... | purposestudies of penile length in children have been rarely conducted . in korea ,
great improvements in height and weight have been observed because of economic development over the past 25 years .
we investigated the current status of penile length in korean children and compared the results with those of a prev... |
retained surgical sponge , also called gossypiboma or textiloma , or instrument is a serious iatrogenic complication that may occur after almost any surgical and even nonsurgical procedures including abdominal , urological , gynecological and obstetrical , endoscopic procedure , and orthopedic surgeries .
a surgical ... | retained surgical sponge ( gossypiboma ) following an inguinal herniorrhaphy is a rare condition and may cause medicolegal problems .
differential diagnosis for the lesion should be made meticulously .
we report a case of a 45-year - old man who had a herniorrhaphy about 8 years previously .
he presented one epis... |
significant corneal astigmatism at the time of cataract surgery is relatively common ; in a large sample of older patients , corneal astigmatism was > 1.0 d in one - third of all eyes.1 if postoperative ( po ) refractive astigmatism is of approximately the same magnitude , uncorrected vision will be compromised.2,3 thi... | purposethe aim of this study was to assess the effectiveness of the verion - lensx guided arcuate incision technique to reduce refractive astigmatism in a pseudophakic population.patients and methodsa prospective single - arm study was conducted in which one or both eyes of subjects required reduction of 1.02.0 d of re... |
ductal carcinoma in situ ( dcis ) is a proliferation of malignant cells inside galactophoric ducts without basal membrane invasion .
its incidence has dramatically increased in the recent years due to the widespread use of mammographic screening .
accounting for approximately 20 to 30% of the breast cancer cases , ... | ductal carcinoma in situ of the breast is associated with low mortality rates , but local relapse is a matter of concern in this disease .
risk factors for local relapse include young age , close or positive margins , and tumor necrosis .
whole breast irradiation following breast - conserving surgery for ductal car... |
gold compounds in the oxidation states
of + 1 and + 3 continue to
be of interest in medicinal chemistry because their efficacies toward
certain diseases can be fine - tuned .
for instance ,
a number of gold(iii ) dithiocarbamates have been reported as anticancer
agents by fregona and co - workers .
this
... | the
reactions of potassium salts of the dithiocarbamates l { where l = pyrazolyldithiocarbamate ( l1 ) , 3,5-dimethylpyrazolyldithiocarbamate ( l2 ) , or indazolyldithiocarbamate
( l3 ) } with the gold precursors
[ aucl(pph3 ) ] , [ au2cl2(dppe ) ] ,
[ au2cl2(dppp ) ] , or [ au2cl2(dpph ) ] lead to the new gold... |
malaria constitutes a major health problem with about 300 - 500 million clinical cases and more than one million deaths annually .
every 40 s , a child dies of malaria resulting in more than 2000 deaths per day among children worldwide .
it causes anemia in pregnancy which increases the risk of maternal deaths with... | background : malaria constitutes a major health problem , with children and pregnant women being the most vulnerable to its morbidity and mortality.aim:to determine the demographic factors associated with the use of insecticide - treated nets among children and pregnant women in nigeria.materials and methods : the stud... |
the extended - spectrum -lactamases ( esbls ) are a group of enzymes that have the ability to hydrolyze and cause resistance to the oxyimino - cephalosporins ( cefotaxime , ceftazidime , ceftriaxone , cefuroxime , and cefepime ) and monobactams ( aztreonam ) , but not the cephamycins ( cefoxitin and cefotetan ) or carb... | since 2000 , escherichia coli producing ctx - m enzymes ( especially ctx - m-15 ) have emerged worldwide as important causes of community - onset urinary tract and blood stream infections due to extended - spectrum -lactamase ( esbl ) producing bacteria .
studies suggest that the sudden worldwide increase of ctx - m-... |
http://www.ncbi.nlm.nih.gov/bioproject/prjna293564 genome information of haloarcula rubripromontorii.organismhaloarcula rubripromontorii , strain sl3sourcecabo rojo , puerto ricogenome size , mb3.97gc content , % 61.97trna48rrna6protein coding sequences3797 solar salterns are hypersaline environments of great historica... | the genus haloarcula belongs to the family halobacteriaceae which currently has 10 valid species . here
we report the draft genome sequence of strain sl3 , a new species within this genus , isolated from the solar salterns of cabo rojo , puerto rico .
genome assembly performed using ngen assembler resulted in 18 co... |
dermathopathic lymphadenitis is a well - described histopathological entity characterized by expansion of subcortical zone by dendritic histocytoid cells .
dermatopathic lymphadenitis represents a benign form of reactive lymph node hyperplasia . the relationship between lymph node hyperplasia and cutaneous disease
... | dermatopathic lymphadenitis is a rare entity described in patients with human immunodeficiency virus infection . here
we present a case of dermatopathic lymphadenitis in a 50-year - old female who was hiv positive and did not have any obvious skin lesions .
fine needle aspiration cytology of the lymphnode showed a ... |
existence of electrical signals in plant cells has been discovered and studied since 1873 [ 13 ] .
the bioelectrochemical or electrophysiological signal is an essentially physical signal in plants as it is the most rapid method of long distance communication when compared with chemical signals such as hormones [ 4 , ... | photosynthesis process in plants generates numerous sources of bioenergy .
however , only a small fraction is readily exploited for electrical energy .
the impact of environmental factors is one of the significant physiological influences on the electrical potential of the plants .
hence , we developed a data acq... |
atopic diseases have a wide range of manifestations across the globe , imposing heavy social and economic burden due to their chronicity and effects on various functions of the body .
allergies during college years impact the quality of life by interfering with the daily activities , poor attendance to college , slee... | aim .
urbanization and globalization in the middle east have resulted in drastic environmental changes and increased allergens present in the environment .
this study aimed to assess the prevalence of allergies among undergraduate students from a university .
material and methods .
this cross - sectional survey... |
the study was conducted in the ate - vitarte district ( population 365,473 ) , which is located 12 km from the center of lima .
it is a marginal urban area that receives immigrants who come to lima with high rates of tb .
the study was reviewed and approved by the ethics committee of the east lima health directorat... | the association between public transportation for commuting and pulmonary tuberculosis ( tb ) was analyzed in workers in lima , peru .
traveling in minibuses was a risk factor for pulmonary tb .
preventive measures need to be taken by health services to prevent spread of this disease . |
multiple chronic medical conditions are increasingly being recognized as a cause of substantial morbidity ( disability ) and mortality [ 13 ] and have been associated with decreased sense of wellbeing and health - related quality of life ( hrqol ) .
yu et al showed that 72% of va patients have at least 1 chronic medi... | backgroundthere is paucity of data concerning the self - perceptions of health status and health - related quality of life ( hrqol ) of veterans with multiple chronic medical conditions.material/methodsveterans who attended an out - patient power wheelchair clinic at a tertiary va medical center were assessed .
healt... |
the study of left ventricular filling dynamics has only recently received the same attention historically associated with systolic dynamics .
doppler tissue imaging ( dti ) is fundamental in this assessment as it allows for the determination of systolic and diastolic velocities in the myocardium .
a number of studi... | backgroundthe aim of the study was to determine the relationship between the rate of peak early mitral inflow velocity and the peak early diastolic mitral annular tissue velocities in normal controls and to compare them with subjects with diastolic dysfunction.methodsthe relationship between early passive diastolic tra... |
chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth , progressive attachment loss , and bone loss and is characterized by periodontal pocket formation and/or recession of the gingiva .
elevated proportions of some subgingival microbial species have been ... | background : the aim of the present study was to evaluate and compare the clinical and microbiological effectiveness of periochip as an adjunct to scaling and root planing ( srp ) with srp alone in patients with chronic periodontitis.materials and methods : this randomized , split mouth , 3-month clinical and microbiol... |
this cross - sectional observational study initially involved 148 consecutive adult ckd patients ( aged 18 years ) who received a single deceased kidney transplant or a simultaneous pancreas - kidney transplant ( n = 4 ) between august 2007 and april 2009 at a regional transplant center ( hospital universitario de cana... | objectivediabetes may accelerate atheromatosis in uremic patients . our aim was to assess the influence of type 1 diabetes on the atheromatosis - related inflammation in patients with chronic kidney disease ( ckd).research design and methodswe analyzed the expression of proinflammatory cytokines and adhesion molecules ... |
db / db and wild - type control mice ( 24 weeks old ) were randomly assigned to four groups : wild type , wild type + berberine ( sigma - aldrich , st .
louis , mo ) , db / db , and db / db + berberine .
the studies were approved by the baylor college of medicine institutional animal care and use committee .
berb... | objectivedefects in insulin / igf-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation .
since an herbal compound , berberine , lowers blood levels of glucose and lipids , we proposed that it would improve insulin / igf-1 signaling , blocking muscle protein los... |
proteolytic enzymes are recognized by their catalytic type , that is , aspartic , cysteine , metallo , serine , threonine , and others as yet unclassified .
almost all metalloproteases contain one or two zinc ions , and several enzymes contain one or two cobalt or manganese ions .
the hexxh motif forming an -helix ... | almost all naturally occurring metalloproteases are monozinc enzymes
. the zinc in any number of zinc metalloproteases has been substituted by some other divalent cation . almost all co(ii)- or mn(ii)-substituted enzymes maintain the catalytic activity of their zinc counterparts . however , in the case of cu(ii ) sub... |
minimally invasive surgery , especially laparoscopic surgical techniques , are increasingly being used in both human and veterinary surgery because of their reported advantages ( less surgical trauma , less postoperative pain , rapid return to normal activity , shorter hospitalization times ) when compared with open pr... | this study was conducted to evaluate the feasibility and therapeutic safety of laparoendoscopic single - site ovariectomy ( less - ove ) and 3-portal laparoscopic ovariectomy ( lap - ove ) in dogs .
ten female mixed breed dogs were included in the study .
dogs were divided into group 1 ( less - ove ; n = 5 ) and gr... |
the tissue doppler imaging ( tdi ) derived pattern of the left ventricular ( lv ) longitudinal motion is characterized by a distinct velocity pattern during the time interval between the end of the systolic velocity wave and the onset of the early diastolic velocity wave .
negative and positive velocity waves are com... | backgrounda distinct velocity pattern represented by a " notch " is observed during the time interval between the end of the systolic and the onset of the early diastolic velocity wave on longitudinal myocardial velocity curve .
the origin of the post - systolic velocity notch ( psn ) has not been resolved.methodsthe... |
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