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peutz - jeghers syndrome ( pjs ) is an autosomal dominantly inherited rare syndrome characterized by mucocutaneous pigmentations , with intestinal and extraintestinal hamartomatous polyps . we report a case of a 37 year old man who admitted to our hospital with complaint of occasionally painless rectal bleeding since...
peutz jeghers syndrome is a rare condition characterized by mucocutaneous pigmentation , polyposis and an increased cancer risk at a number of gastrointestinal and extra intestinal organs . we present a patient with a history of gastrointestinal bleeding with no mucocutaneous pigmentation . upper and lower gastroi...
gastrointestinal ( gi ) problems in critically ill patients are common and associated with impaired outcome [ 14 ] . the hypothesis of the gut as a motor of multiple organ failure ( mof ) has repeatedly been proposed in the past [ 5 , 6 ] . despite this , the pathophysiological role of gi dysfunction in the clinical co...
purposethe study aimed to develop a gastrointestinal ( gi ) dysfunction score predicting 28-day mortality for adult patients needing mechanical ventilation ( mv).methods377 adult patients from 40 icus with expected duration of mv for at least 6 h were prospectively studied . predefined gi symptoms , intra - abdomina...
copd is the third leading cause of death worldwide1 and the second leading cause of disability - adjusted life - years lost.2 according to the global initiative for chronic obstructive lung disease ( gold ) , copd is defined by a nonfully reversible airway obstruction expressed as a ratio of the postbronchodilator forc...
backgroundin addition to their respiratory symptoms , patients with copd experience multiple , co - occurring symptoms.objectivesthe aims of this study were to identify subgroups of copd patients based on their distinct experiences with 14 symptoms and to determine how these subgroups differed in demographic and clinic...
inhalation injury is a common occupational hazard and may be because of smoke or chemical substances ( fumes ) . chemical inhalation is sometimes cause of severe respiratory distress and may even lead to acute respiratory distress syndrome ( ards ) . phosgene ( carbonyl chloride ; chemical formula cocl2 ) has been ...
irritant gas exposure may lead to significant respiratory distress as is seen in the present case of 25 year old male worker who suffered accidental phosgene inhalation . he remained asymptomatic for six hours but later landed up in acute respiratory distress syndrome in the hospital and required ventilatory support ...
about 1 in 5,000 male births in the united states results in hemophilia which is an x - linked bleeding disorder . in the 19th century , hemophilia was a rare disease in adulthood , with a median life expectancy of 11 years . life expectancy increased when clotting factors were developed in the 1960s , with many pa...
background . the etiology of the high prevalence of hypertension among patients with hemophilia ( pwh ) remains unknown . methods . we compared 469 pwh in the united states with males from the national health and nutrition examination survey ( nhanes ) to determine whether differences in cardiovascular risk factors...
we report aunique case of successfully performed intraluminal brachytherapy for low volume urethral mucosal recurrence of transitional cell carcinoma urinary bladder , initially treated by transurethral resection of bladder tumor followed by radical cystectomy . a 40 year old man attended the oncologic out - patient ...
we report a unique case of successfully performed intraluminal brachytherapy for low volume urethral mucosal recurrence of transitional cell carcinoma urinary bladder , initially treated by transurethral resection of bladder tumor , followed by radical cystectomy . since the patient was unwilling to undergo any other o...
aquaporin ( aqp ) is a water - transporting protein that has a variety of physiological functions in the skin [ 1 , 2 , 3 ] . among aqps it has been reported that the expression of aqp-5 is involved in the sweating of mice , rats , and horses . while aqp-5 was reported to be aberrant in the sweat glands in aquageni...
aquaporin-5 ( aqp-5 ) is a water - transporting protein expressed in mammal sweat glands . it has been reported that the expression of aqp-5 is involved in sweating of mice , rats , and horses . however , the physiological function of human aqp-5 is still uncertain . in this report , we examined the expression pa...
this phase ii trial was a prospective randomized double - blind placebo - controlled parallel - group study conducted between april 2007 and may 2008 at 118 sites in the u.s . ( n = 106 ) , mexico ( n = 9 ) , chile ( n = 2 ) , and the dominican republic ( n = 1 ) ( online appendix 1 , available at http://care.diabete...
objectiveto evaluate the efficacy , safety , and tolerability of incremental doses of albiglutide , a long - acting glucagon - like peptide-1 receptor agonist , administered with three dosing schedules in patients with type 2 diabetes inadequately controlled with diet and exercise or metformin monotherapy.research desi...
multiple sclerosis ( ms ) is a chronic and disabling neurologic disease that is common among adults worldwide and in the united states . the relapsing - remitting clinical disease course , accounting for nearly 85% of cases , involves episodes of focal inflammation in the central nervous system ( cns ) that often r...
objectives . to examine the association between fall history and physical activity using an objective measure of physical activity ( i.e. , accelerometry ) in persons with multiple sclerosis . design . a community - based sample of 75 ambulatory persons with multiple sclerosis volunteered for the investigation . part...
alternative splicing ( as ) is a fundamental cellular process involved in eukaryotic gene expression ( 13 ) . to decipher the molecular mechanisms responsible for as , several computational studies have been presented over the last years , producing a considerable quantity of dedicated analyses and databases represen...
in the process of establishing more and more complete annotations of eukaryotic genomes , a constantly growing number of alternative splicing ( as ) events has been reported over the last decade . consequently , the increasing transcript coverage also revealed the real complexity of some variations in the exon intr...
computed tomography ( ct ) of the lungs is an invaluable adjunct in the diagnostic work - up of lung disease . the normal lung has a characteristic pattern of x - ray attenuation , with each region 's attenuation ( in hounsfield units ) being determined by the average of the relative content of air ( most negative ) ...
computed tomography ( ct ) chest is widely used as an adjunct to clinical examination and pulmonary function tests in the evaluation of unexplained dyspnoea . in such patients , heterogeneous lung attenuation is a common finding on ct . heterogeneous lungs can be caused by varying regional aeration , varying region...
magnetic resonance imaging ( mri ) is a powerful diagnostic tool used in both clinical and research settings due to its capacity to render images with high spatial and temporal resolution . unlike other imaging modalities , mr does not require the use of ionizing radiation or suffer from limited depth penet...
multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal resolution . in particular , mr and optical imaging are an attractive combination that can be used to determine both molecular and anatomical information ...
the online version of this article ( doi:10.1007/s11306 - 011 - 0343-y ) contains supplementary material , which is available to authorized users . type 1 diabetes follows the autoimmune destruction of pancreatic beta - cells at a young age . acute symptoms can be controlled by insulin injections , but the diabetes...
diabetic kidney disease , diagnosed by urinary albumin excretion rate ( aer ) , is a critical symptom of chronic vascular injury in diabetes , and is associated with dyslipidemia and increased mortality . we investigated serum lipids in 326 subjects with type 1 diabetes : 56% of patients had normal aer , 17% had micr...
the hoorn study is a population - based cohort study of glucose metabolism of 2,484 dutch caucasian men and women , aged 5075 years at study initiation in 1989 . the study design and population have been described in detail elsewhere ( 16 ) . for the current study , we included participants with ngt ( n = 1,791 ) ,...
objectiveto test the validity of the framingham , systematic coronary risk evaluation ( score ) , and uk prospective diabetes study ( ukpds ) risk function in the prediction of risk of coronary heart disease ( chd ) in populations with normal glucose tolerance ( ngt ) , intermediate hyperglycemia , and type 2 diabetes....
a health sector perspective was adopted for the economic evaluation , comprising direct health care costs to government , private insurers , and patients . an incremental cost - effectiveness analysis was undertaken , wherein the net costs and net efficacy of surgical therapy as compared with conventional therapy wer...
objectiveto determine the within - trial cost - efficacy of surgical therapy relative to conventional therapy for achieving remission of recently diagnosed type 2 diabetes in class i and ii obese patients.research design and methodsefficacy results were derived from a 2-year randomized controlled trial . a health sec...
integrins are a large family of heterodimeric cell - surface receptors comprising one and one chain . to bind to ligands , integrins must first undergo a conformation change in a process known as activation . in leukocytes , these conformational changes can be initiated by signaling downstream of other agonists such ...
cell motility requires the temporal and spatial coordination of the actin cytoskeleton with cell - matrix adhesions . since their discovery more than 20 years ago , integrins have been at the center of cell - matrix adhesion research . integrin - mediated adhesions link the actin network to the extracellular matrix a...
puberty starts when the level of sex hormones in the body rises and is marked by the development of secondary sexual characteristics , accelerated growth , behavioral changes , and eventual attainment of reproductive capacity . the onset of puberty is different in various ethnic groups . besides the numerous intrinsi...
objectivethis investigation aims to evaluate the validity of a persian tanner stages self - assessment questionnaire.methodsin this cross sectional study , 190 male students aged 8 - 16 years selected from three layers of different regions of tehran ( north , central and south ) were enrolled . a persian questionnair...
partners who had advocated for the program were then in the position to identify guidelines and definitions to formalize the application process and operationalize the new policy . tools that were used during advocacy efforts , such as maps and broad definitions of need , were useful to explain the scope and severity...
supplemental digital content is available in the text.this article describes a process to implement an eligibility analysis for healthy food financing programs and shares lessons learned from administering the pennsylvania , new york , and new orleans healthy food financing programs over the course of the past 9 years ...
genetically encoded fluorescent proteins ( fps ) and biosensors make it possible to optically record cell signaling , migration , and death in living organisms , see , e.g. , refs ( 24 ) . today , the most significant constraint to imaging deep inside whole organisms is the strong scattering and absorption ...
genetically encoded fluorescent proteins ( fps ) , and biosensors based on them , provide new insights into how living cells and tissues function . ultimately , the goal of the bioimaging community is to use these probes deep in tissues and even in entire organisms , and this will require two - photon laser...
polycystic ovary syndrome ( pcos ) is considered to be the most common endocrine disorder in the women of reproductive age , with onset manifesting as early as puberty . pcos prevalence is estimated to be about 68% , although with the implementation of the rotterdam criteria , the prevalence increased up to 1525% , w...
objective . to compare the effectiveness of myo - inositol ( mi ) and oral contraceptive pills ( ocps ) in monotherapy and mi in combination with ocps in the treatment of teenagers affected by polycystic ovary syndrome ( pcos ) . methods . 61 adolescent girls aged 1319 years , with pcos , were involved in the prospec...
the need for technologies that allow highly parallel quantitation of specific proteins in a rapid , low - cost and low - sample - volume format has become increasingly apparent with the growing recognition of the importance of global approaches to molecular characterization of physiology , development , and disease . ...
background : we have developed and tested a method for printing protein microarrays and using these microarrays in a comparative fluorescence assay to measure the abundance of many specific proteins in complex solutions . a robotic device was used to print hundreds of specific antibody or antigen solutions in an array ...
macrocyclic ligands , particularly aza - substituted crown and thiocrown ethers , are commonly utilized in the design of cation - selective fluorescent probes responding with either a spectral shift or enhancement in fluorescence emission . if an n - aryl azacrown moiety serves as the electron - donor in fluo...
ternary complex formation with solvent molecules and other adventitious ligands may compromise the performance of metal - ion - selective fluorescent probes . as ca(ii ) can accommodate more than 6 donors in the first coordination sphere , commonly used crown ether ligands are prone to ternary complex formati...
coronary artery disease ( cad ) is one of the leading causes of death in the world . familial aggregation of cad indicates the contribution of genetic factors which might be involved in disease development . genome - wide association studies have identified approximately 34 distinct loci in correlation with cad . ...
subject & aim . endothelial nitric oxide synthase ( enos ) is one of the most important candidate genes in cad . a functional polymorphism within enos gene is a 27 bp vntr on its intron 4 which has been shown to be associated with various diseases . in this study we investigated enos vntr polymorphism in addition ...
when performing minimally invasive laparoscopic and thoracoscopic surgery , using an extracorporeal knotting technique can facilitate suturing . in minimally invasive surgery , the most common technique for suturing ( for example in nissen rossetti fundoplication , a blood vessel , a cystic duct , or at the base of t...
this paper describes the scissor - knot - pusher , an instrument that greatly facilitates the execution of knot tying during laparoscopic operations . the instrument acts in essence as an extension of the surgeon 's hand and , given its rigid structure , allows the surgeon full control of the process of knot tying ...
osteoporosis is a disease characterized by decreased bone density and loss of bone microstructure which can lead to an increased risk of fracture ( 1 ) . bone mass in females is significantly less than that of the males of the same age and race ( 3 ) . in both sexes , the peak bone mass is achieved by the age of 30...
background : several studies reported the efficacy of osteoporosis prevention interventions in improvement of people s preventive behaviors . however , there are reports that the interventions were not successful in altering osteoporosis health beliefs and preventive behaviors.objectives:the current study aimed to asse...
we present the case of a 64-year - old patient who presented to his primary care physician with fatigue , worsening shortness of breath , abdominal discomfort and a rapidly growing abdominal girth , although he had lost 5 kg of weight within 3 months . he had a history of untreated hypertension , compensated renal in...
backgroundwe present the case of a 64-year - old patient who presented to his primary care physician with fatigue , worsening shortness of breath , abdominal discomfort and a rapidly growing abdominal girth , although he had lost 5 kg of weight within 3 months . he had a history of untreated hypertension , compensate...
according to some recent reports , neoadjuvant chemoradiation therapy ( ncrt ) followed by curative surgery has become the therapy of choice in locally advanced rectal cancer . ncrt was introduced to improve local disease control , and several large randomized trials have demonstrated a significant benefit from this ...
purposerestaging after neoadjuvant treatment is done for planning the surgical approach and , increasingly , to determine whether additional therapy or resection can be avoided for selected patients.materials and methodslocal restaging after neoadjuvant chemoradiation therapy ( ncrt ) was performed in 270 patients with...
sebaceous hyperplasia ( sh ) is a common , benign condition of sebaceous glands in adults of middle age . it presents as yellow papules most commonly over face with occasional involvement of chest or genitalia . typical facial papules appear in middle age , are larger than lesions on areola or mouth and display a c...
sebaceous hyperplasia ( sh ) , a common , benign condition of sebaceous gland , presents most commonly over face . lesions are usually described as asymptomatic , soft , discrete , and yellow with a surface that ranges from smooth to slightly verrucous . the pathogenesis is not fully understood . it does not requ...
an estimated 35 million people live with human immunodeficiency virus ( hiv ) globally with more than two - thirds ( 70% ) of these people residing in sub - saharan africa . as the most populous country in africa , nigeria accounts for about 10% of the world 's total aids population and has 3.2 million people living ...
background : one of the reported obstacles to the achievement of universal access to human immunodeficiency virus ( hiv ) prevention , treatment , care , and support programs includes stigma and discrimination from health workers , particularly nurses . since nursing students would become future practising nurses and...
there is great interest in understanding the composition of the tissue microenvironment and its consequence for immune responses . one of the most important microenvironmental factors is the oxygenation status of tissues , since oxygen affects a plethora of cellular processes including innate and adaptive cellular im...
tryptophan is an essential amino acid for hosts and pathogens . the liver enzyme tryptophan 2,3-dioxygenase ( tdo ) provokes , by its ability to degrade tryptophan to n - formylkynurenine , the precursor of the immune - relevant kynurenines , direct and indirect antimicrobial and immunoregulatory states . up to now ...
the hypereosinophilic syndrome ( he s ) is a group of disorders characterized by overproduction of eosinophils that cause involvement in multiple organs including heart . definition of he s includes persistent eosinophilia ( > 1500/mm ) in the absence of other apparent causes of eosinophilia such as parasitic or alle...
cardiac involvement is a major cause of morbidity and mortality in hypereosinophilic syndrome ( he s ) . it is classified into 3 stages by the degree of eosinophils - mediated heart injury ; acute necrotic stage , thrombotic stage , and fibrotic stage . nonetheless , definitive evidence that each patient passes seque...
keratins are obligate heteropolymers composed of type i ( acidic , k9 through k20 ) and type ii ( neutral - basic , k1 through k8 ) subunits , which form filaments intermediate in size between actin microfilaments and microtubules . skin abnormalities associated with mutations of specific epidermal keratins have prov...
tumor necrosis factor ( tnf ) is a cytokine produced by macrophages and t lymphocytes that acts through two distinct receptors , tnfr1 ( 60 kd , cd120a ) and tnfr2 ( 80 kd , cd120b ) , to affect cellular proliferation , differentiation , survival , and cell death . in addition to its proinflammatory actions in mucosa...
type 2 diabetes ( t2d ) is characterized by chronic hyperglycemia that develops when pancreatic -cell insulin secretion fails to compensate for the deterioration in insulin sensitivity ( 1 ) . physical activity aimed at improving cardiorespiratory fitness is prescribed as part of standard - of - care treatment for t2...
objectivecardiorespiratory fitness ( vo2max ) is associated with glycemic control , yet the relationship between vo2max and the underlying determinants of glycemic control is less clear . our aim was to determine whether vo2max is associated with insulin sensitivity , insulin secretion , and the disposition index , a m...
. they can almost develop in any part of the body , while head , neck and extremities are the most common sites . schwannomas can show secondary degenerative changes including cyst formation , hyalinization , hemorrhage , and calcification , whereas the ossified retroperitoneal schwannoma was only reported in a malig...
abstractbackground : schwannomas are mesenchymal tumors arising from the neural sheaths of peripheral nerves . they can almost develop in any part of the body , while head , neck and extremities are the most common sites . occurrence in the retroperitoneum is rare . schwannomas can show secondary degenerative cha...
in chronic glaucomatous diseases , severity is often characterized by clinically visible optic disc cupping . however , in primary acute angle closure ( aac ) , glaucomatous optic neuropathy may develop without any obvious cupping . although visual field is still the gold standard investigation for glaucoma , its use...
abstractthe purpose of this article is to investigate the long - term retinal nerve fiber layer ( rnfl ) status and determinants of rnfl thinning after an episode of unilateral primary acute angle closure ( aac).this cross - sectional study analyzed the medical records of consecutive patients with a single episode of u...
to examine whether lineage - based rules contribute to functional circuit organization in the optic tectum , we developed a method for labeling a single neuronal clone per animal , which enabled us to definitively identify sister tectal neurons . individual tectal progenitor cells in the proliferative zone of stage...
summaryunderstanding how neurons acquire specific response properties is a major goal in neuroscience . recent studies in mouse neocortex have shown that sister neurons derived from the same cortical progenitor cell have a greater probability of forming synaptic connections with one another [ 1 , 2 ] and are biase...
emergence and spread of multidrug - resistant ( mdr ) acinetobacter baumannii in nosocomial settings has become a serious concern in clinical practice . the organism commonly targets critically ill patients in intensive care units ( icu ) and burn wards ( 1 ) . the infections caused by this organism include bactere...
background : emergence of multidrug - resistant acinetobacter baumannii has resulted in the treatment failure of related infections and an increase in patient mortality . the presence of class d -lactamases ( oxacillinases ) in this organism is an important mechanism underlying resistance to beta - lactam antibiotics...
the success rate of single - bundle anterior cruciate ligament ( acl ) reconstruction , which is regard as a common orthopedic procedure , is 83% to 95%13 ) . in particular , the conventional single - bundle acl reconstruction using an 11- or 1-oclock femoral tunnel has been considered effective in restoring anteropo...
purposethe purpose of this study was to evaluate the mid - term outcomes of anatomic anterior cruciate ligament ( acl ) reconstruction using two anteromedial ( am ) portals by comparing with short - term follow - up results.materials and methodsfifty patients who were treated by acl reconstruction using a two am portal...
lissencephaly is a rare disorder of neuronal migration , characterized by the absence of cerebral convolutions and a poorly formed sylvian fissure giving the appearance of a smooth brain as occurring normally at 34 months of fetal life . it is a genetically heterogeneous condition with autosomal dominant , autosomal ...
x - linked lissencephaly with ambiguous genitalia is a rare and recently described syndrome . we report a neonate presenting with the classical features of the syndrome which includes lissencephaly , agenesis of the corpus callosum , intractable epilepsy of neonatal onset , acquired microcephaly , and male genotype w...
alzheimer 's disease ( ad ) is the leading cause of dementia in people over 65 , and it affects more than 20 million people worldwide . no cure has yet been found , and current pharmacological therapy only temporarily ameliorates the symptoms . recent research has focused on preventive strategies derived from a hea...
the 3xtg - ad mouse develops a progressive alzheimer 's disease- ( ad- ) like brain pathology that causes cognitive- and neuropsychiatric - like symptoms of dementia . since its neuroimmunoendocrine axis is likewise impaired , this mouse is also useful for modelling complex age - related neurodegeneration . this st...
ultrasonography revealed a well - defined echogenic mass containing multiple anechoic areas in the inferior pole of the right kidney ( fig . selective renal angiography showed avascularity of the mass and displacement of the interlobar and segmental arteries . the mass was spongy - like and consisted of multiple bl...
renal hemangioma is an uncommon benign tumor which usually causes painless or painful gross hematuria . its preoperative diagnosis is extremely difficult or even impossible.we experienced three cases of renal hemangioma , located mainly at the pelvocalyceal junction or in the inner medulla . us demonstrated variabl...
osteoporosis is a systemic disorder characterized by low bone mass and microarchitectural deterioration of bone tissue , which predisposed old people to bone fragility and fracture risk , is known as the second widespread public health problem after cardiovascular diseases ( 1 ) . this pathology is more often related...
the purpose of the present study was to examine the effect of 3-years of moderate multi - component exercise training on bone mineral density and bone mineral content in a female subject with osteoporosis . a 57-year - old postmenopausal woman , a known case of osteoporosis following an accident , participated in thi...
hpvg was first described in infants with necrotizing enterocolitis ( nec ) by wolfe and evans in 1955 , and was then reported in increasing frequency in adults as well . hpvg has been most commonly associated with an acute gastrointestinal catastrophe , such as mesenteric ischemia , with up to 80% of cases resulting ...
portal venous gas or hepatic portal venous gas ( hpvg ) found on imaging portends grave outcomes for patients suffering from ischemic bowel disease or mesenteric ischemia . hpvg is more rarely seen with severe but treatable abdominal infection as well as multiple benign conditions , and therefore must be aggressively...
invasive trichosporonosis is a life - threatening fungal infection mostly reported in patients with hematologic malignancies and sometimes in patients with peritoneal dialysis or solid tumors . despite its rarity , trichosporon spp . has been reported as the second most common yeast after candida in patients with hem...
we report a case of a 51-year old man with a severe aplastic anemia who developed an invasive trichosporonosis to trichosporon faecale with fungemia and skin lesions during severe neutropenia . the treatment was successful before neutrophil recovery with a combination of voriconazole and liposomal amphotericin b.
nonunion following surgical stabilization of humeral shaft fractures , although infrequent , remains a challenge as limited surgical options are available . the difficulties in re - fixation are due to osteolysis produced by the loose implant components and disuse osteopenia of the entire bone segment . we share ou...
introduction : nonunion following surgical stabilization of humeral shaft fractures , although infrequent , remains a challenge as limited surgical options are available . the difficulties in re - fixation are due to osteolysis produced by the loose implant components and disuse osteopenia of the entire bone segment ...
accumulating evidence suggests that oxidative stress plays an important role in the pathogenesis of human chronic disease , such as cancer and cardiovascular disease . emerging from in vitro studies therefore , the intake of antioxidant vitamins has been hypothesized to improve human survival and longevity . there...
backgroundfew studies have evaluated dietary antioxidant vitamins intake in relation to risk of mortality in asia.methodswe examined the associations between total carotene , vitamin c , and vitamin e from diet and risk of mortality from all causes , cancer , and cardiovascular disease in 134,358 participants ( 59,739 ...
depression is a mental disorder that is characterized by persistent feelings of sadness and loss of interest . it affects how you feel , think , and behave and it can lead to disturbances of daily habits ( e.g. , work ) . the complexity of depression is demonstrated by the existence of a variety of factors involved...
depression can be both normal and abnormal , and the balance of its expression determines the behavioral outcome / diagnosis . it is a complex pathophysiology based on a heterogeneous syndrome whose etiology is diverse as well . within the context of a central nervous system , the nervous system blueprint can be foun...
within the cell , molecules are synthesized , trafficked , and degraded at high turnover rates . in addition , high molecular densities lead to crowding effects that hinder protein diffusion and create a need for actively driven transport mechanisms . because trafficking of materials and signals within cells is activel...
photoactivatable fluorescent proteins offer the possibility to optically tag and track the location of molecules in their bright state with high spatial and temporal resolution . several reports of patterned photoactivation have emerged since the development of a photoactivatable variant of the green fluorescent prot...
the cornea is a transparent , avascular tissue that measures 1112 mm horizontally and 1011 mm vertically.1 the cornea along with sclera forms the outermost coat of the eyeball , it is a complex structure which , as well as having a protective role , is responsible for about three quarters of the optical power of the ey...
backgroundcentral corneal thickness ( cct ) is an important indicator of corneal status . its measurement provides valid information about corneal physiological condition and possible changes associated with diseases , traumas , and hypoxia . it is an integral part for interpretation of intraocular pressure and gla...
formin family proteins nucleate actin polymerization and remain bound to the barbed ends of actin filaments , enabling filament growth in the barbed direction at the same time ( for review see higgs , 2005 ) . the latter phenomenon , which is referred to as processive or leaky capping , has been directly visualized...
the fh2 domains of formin family proteins act as processive cappers of actin filaments . previously suggested stair - stepping mechanisms of processive capping imply that a formin cap rotates persistently in one direction with respect to the filament . this challenges the formin - mediated mechanism of intracellula...
we report here the case of a woman admitted for progressive renal failure with a history of hypertension , osteoporosis and recent therapy for breast cancer , presenting with significant hypercalcaemia , hyperphosphataemia and bicytopaenia . a 70-year - old woman with a history of hypertension and osteoporosis presen...
sarcoidosis can affect all organs and may mimic a variety of other diseases . in the absence of typical pulmonary features , extrapulmonary manifestations may be difficult to diagnose . we describe here the very uncommon case of a patient with mild pulmonal involvement but distinct renal , bone marrow and lymph node ...
the online version of this article ( doi:10.1007/s00251 - 012 - 0640 - 2 ) contains supplementary material , which is available to authorized users . ( docx 27 kb ) peptide spot array sequences of the three rhesus macaque kir3d proteins . this article is distributed under the terms of the creative commons attribut...
killer immunoglobulin - like receptors ( kirs ) represent a highly polymorphic and diverse gene family in rhesus macaques . analyses of the respective gene products have been hampered until now due to non - availability of specific monoclonal antibodies and failure of cross - reactivity of anti - human kir antibodies...
war is a man made nightmare which affects people directly and indirectly.the war results in prolonged problems that are silent and invisible ( 1 ) . the 1980 - 1988 iraq - iran war left about 188,000 martyrs and 378,540 disabled veterans and war prisoners , however after two decades the causalities have continued . ...
backgroundthe main aim of this study was to assess the prevalence of depression and general anxiety of the prisoners of war ( pow ) children . the study was also designed to compare the prevalence of depression and general anxiety amongst the pow 's children and normal adults , 20 years after the iraq - iran war.meth...
macrophage activation syndrome ( mas ) is a clinical entity characterized by serious liver diseases , hematologic abnormalities , coagulopathy resembling disseminated intravascular coagulation , and neurologic involvement . mas is known to be a severe and potentially life - threatening complication of rheumatic disor...
macrophage activation syndrome ( mas ) is a rare and potentially fatal complication of rheumatic disorders in children . we describe a 13-month - old boy in whom mas developed as a complication of systemic juvenile rheumatoid arthritis ( s - jra ) . he suffered from fever and generalized rash followed by multiple j...
carica candamarcensis ( caricaceae ) is a plant native to western south america , popularly known as mountain papaya . after injury , the leaves and outer layers of the endocarp release a large amount of latex that is rich in carbohydrates , vitamins , minerals , and proteins [ 1 , 2 ] . previously , laticifer prot...
the immunomodulatory properties of a mixture of cysteine peptidases ( p1g10 ) obtained from the fruit lattice of carica candamarcensis were investigated . p1g10 was obtained from fresh latex samples by chromatography in a sephadex column and initially administered to swiss mice ( n = 5 ; 1 or 10 mg / kg ) via i.p . ...
a family crisis is an interruption in the routine of a family that leads to disorganization of the family homeostasis . when a crisis occurs in a family , the family resources and coping strategies to manage stress may not be effective . resources are those features and supports that are accessible for use by the f...
objective . the aim of this study was to investigate the psychometric properties of the family inventory of resources for management ( firm ) in a sample of family caregivers of cancer patients . methods . in this methodological study , construct validity of the firm was evaluated by known groups and convergent v...
in egypt , mycotoxins are a concern for public health . the major sources of mycotoxins in egypt are spices , agricultural crops , meat and milk products . a survey was performed to detect afs in fresh and processed meat products in cairo . beef burgers , sausage and luncheon meat had the highest mould count ...
abstractmycotoxins are fungal secondary metabolites that contaminate various feedstuffs and agricultural crops . the contamination of food by mycotoxins can occur before production , during storage , processing , transportation or marketing of the food products . high temperature , moisture content and water ac...
immunotherapy with checkpoint inhibitors has proven to yield remarkable responses in a variety of malignancies . it has been shown that in colorectal cancer ( crc ) , tumours with mismatch - repair - deficiency are especially susceptible to blockade with antibodies targeting pd-1 or pdl-1 . to the best of our knowl...
here , we report the history of a 42-year - old female patient with sporadic mismatch - repair - deficient metastatic colorectal cancer and abdominal bulky disease , who received pembrolizumab ( 200 mg every 3 weeks ) after the failure of third - line treatment . restaging 3 months after initiation of treatment reve...
lipopolysaccharide ( lps ) , a component of the outer membrane of gram - negative bacterium h. pylori colonizing the gastric mucosa , is recognized as a potent endotoxin responsible for eliciting mucosal inflammatory responses that characterize gastritis and duodenal ulcers [ 1 , 2 ] . indeed , the gastric mucosal re...
ghrelin , a peptide hormone produced mainly in the stomach , has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity . here , we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells ...
isolated spontaneous dissection of the superior mesenteric artery ( sma ) without aortic involvement is a rare event . diagnosis may have been difficult in the past , but recent advances in imaging modality and knowledge of mesenteric arteries disease have rendered diagnosis easier.1 that is perhaps why this disease ...
isolated dissection of the superior mesenteric artery is a rare occurrence with a hitherto unknown exact etiology . patients may present with abdominal symptoms or hemodynamic instability.we herein present a case of spontaneous isolated superior mesenteric artery dissection in a 48-year - old man , who was admitted w...
juvenile xanthogranuloma ( jxg ) is a proliferative histiocytic disorder of childhood and regarded as a non - langerhans cell histiocytosis7 ) . jxg is not a true neoplasm but rather a reactive proliferation of histiocytes and the etiology and pathogenesis are still unknown . the clinical features have been describ...
we present the rare case of solitary xanthogranuloma in the upper cervical column mimicking a brown - sequard syndrome . a 29-year - old man complained with right hemiparesis and left hypoesthesia after a car accident . computed tomography and magnetic resonance images revealed a lobulated homogenously well - enhanci...
some oncogenes such as erbb2 and egfr are over - expressed in only a subset of patients . cancer outlier profile analysis is one of computational approaches to identify outliers in gene expression data . a database with a large sample size would be a great advantage when searching for genes over - expressed in only...
background : some oncogenes such as erbb2 and egfr are over - expressed in only a subset of patients . cancer outlier profile analysis is one of computational approaches to identify outliers in gene expression data . a database with a large sample size would be a great advantage when searching for genes over - expr...
prostate - specific antigen ( psa ) , a single - chain 33 kda glycoprotein serine protease , is produced by the human prostate epithelium only . it is the most widely used tumor marker for the diagnosis of prostate cancer , which is common in aging men . more than 80 percent of prostate cancers are found in men mor...
purposeprostate cancer is rarely diagnosed in men younger than 40 years of age . at present , the available data show a low rate of cancer detection from prostate - specific antigen ( psa ) screening of this group of young men . we analyzed the outcome of prostate biopsy results in patients of this age group with a h...
an 80-year - old , right - handed man , without personal or familial neuropsychiatric history was brought by his family to our clinic for his hallucinations . the patient had a one - year history of visual hallucinations , including different types of children such as colorfully dressed boys who caress his arms , sma...
the charles bonnet syndrome ( cbs ) is typically characterized by visual hallucinations in elderly people without cognitive defects . this article presents the case of an 80-year - old male patient with a one - year history of visual hallucinations , secondary to glaucoma , in both eyes . neither a dopamine agonist n...
it has been a working assumption of chronobiologists that the harms of shift - worker dysrhythmia would be most effectively mitigated if , instead of altering activity rhythms volitionally or pharmacologically , the phase of the circadian pacemaker and its outputs could be reset to correspond with the desired schedule ...
circadian disruption in shift - work is common and has deleterious effects on health and performance . current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker , which unfortunately in humans , shifts slowly and often incompletely . temporal reorganization of rhythmic wavefor...
multicentric reticulohistiocytosis ( mrh ) is a rare histiocytic proliferative disease in which joints , skin , mucous membranes and internal organs are affected . . twenty five percent of the patients have an associated internal malignancy at various sites . mrh has few other names in the literature as lipoid derm...
a 58-year - old lady presented with polyarthritis followed by multiple shiny erythematous dome - shaped papulonodules mainly over the face , around joints and coral bead sign on fingers without any mucosal involvement . characteristic histopathology with well - defined dermal infiltrate consisting of multinucleated g...
dorsalis pedis artery ( dpa ) aneurysms , though uncommon , are well recognized clinical presentation and it was first described by cuff in 1907 ( 1 ) . then after , many case reports have described this rare aneurysm and proposed different management modalities . this article presents a case of true dpa saccular ane...
aneurysms of the foot arteries are rare . a case of a true dorsalis pedis artery saccular aneurysm in a 60 years old man in which there was no history of trauma is presented . the arterial duplex , intraoperative features , operative procedure and literature review are presented and discussed .
in the final third of the 20th century , chemists began to explore the role of electron tunneling in reactions between molecular species . the semiclassical theory of electron - transfer ( et ) ( eq 1 ) reactions formulated by , inter alia , marcus and levich and dogonadze provided a theoretical underpinning fo...
electrons have so little mass that in less than a second they can tunnel through potential energy barriers that are several electron - volts high and several nanometers wide . electron tunneling is a critical functional element in a broad spectrum of applications , ranging from semiconductor diodes to the p...
in this paper we report yields , identities , and mutagenicities of products from heating a polycyclic aromatic hydrocarbon ( pah)-contaminated , superfund - related synthetic soil matrix without exogenous oxygen . we heated batch samples of soil pretreated with 5.08 wt% ( by weight ) pyrene in a tubular furnace unde...
classically dental caries is defined as a multifactorial disease whose development requires a susceptible host , cariogenic bacteria , and a contribution from the diet ; even if nowadays a new paradigm of dental caries has been postulated . this latter asserts that the caries process is the ubiquitous , natural metab...
the exact mechanisms and enzymes involved in caries progression are largely unclear . apoptosis plays a key role in dentin remodelling related to damage repair ; however , it is unclear whether apoptosis in decayed teeth is activated through the extrinsic or the intrinsic pathway . this ex vivo immunohistochemical ...
first branchial cleft cysts ( fbccs ) are extremely rare causes of parotid swellings and comprise less than 1% of all branchial anomalies . this was a case report of a 22-year - old female with an unremarkable medical and family history who presented to us with a painless swelling in the left parotid region of 2 year...
branchial cleft anomalies are caused by incomplete regression of the cervical sinus of his during the 6th and 7th weeks of embryologic development . although congenital in origin , first branchial cleft cysts ( fbccs ) can present later in life . fbccs are rare causes of parotid swellings , accounting for < 1% of...
tuberculosis ( tb ) is a chronic infectious disease in wildlife caused by bacteria of the mycobacterium tuberculosis complex ( mtc ) . several members of the mtc can be distinguished , mycobacterium caprae being one of them . m. caprae , the aetiological agent found in our study , can infect a wide range of domesti...
a survey of 143 hunter - harvested red deer for tuberculosis was conducted in an alpine area in western austria over two subsequent years . there , single tuberculosis cases caused by mycobacterium caprae had been detected in cattle and red deer over the preceding decade . the area under investigation covered approxi...
spinal cord injury patients , who manage their bladder using a condom catheter , are at risk of developing urine retention when they consume large volumes of alcoholic drinks within a short period of time . he went out socializing during which he consumed large volumes of alcohol but did not take any recreational dru...
backgroundspinal cord injury patients , who manage their bladder using a condom catheter , are at risk of developing urine retention when they consume large volumes of alcoholic drinks within a short period of time.case presentationa male tetraplegic patient had been managing satisfactorily penile sheath drainage for 8...
the mathematical theory of darwinian dynamics provides tools for understanding and predicting responses to somatic selection , including clonal adaptation , diversification and extinction ( vincent and brown 2005 ) . this framework has been used to develop explanatory models of cancer initiation , promotion and progr...
there is increasing evidence that darwin 's theory of evolution by natural selection provides insights into the etiology and treatment of cancer . on a microscopic scale , neoplastic cells meet the conditions for evolution by darwinian selection : cell reproduction with heritable variability that affects cell surviva...
with the increasing use of straight wire or pre - adjusted appliances in orthodontics , practitioners are switching their focus from wire bending to bracket positioning . in fixed - appliance treatment , one of the most important requirements is correct bracket positioning.1 bonding orthodontic brackets with visible ...
objectives : the aim of this study was to compare the shear bond strength ( sbs ) of two different light sources under different thermal cycle frequencies.methods:ninety human premolar teeth were divided into six groups , in which three groups consisted of halogen groups group i was cured with halogen without thermoc...
the arch of the human foot is intrinsically unstable and to make the bipedal gait more effective and efficient , certain evolutionary musculoskeletal adjustments are in progress that are reflected in many of the muscles and bones of the foot . phylogenetically , the human fibularis tertius ( ft ) muscle is relatively...
fibularis tertius ( ft ) is often considered as part of extensor digitorum longus ( edl ) muscle . the muscle is absent in hominoid apes and with the acquisition of the bipedal gait ; the muscle emerged as a recent addition in the human foot . from its various modes of insertions , it is evident that the muscles of t...
the role of private funding in long - term care programmes ( ltc ) is increasing worldwide . as stated by the world health organisation ( who ) although this is well accepted in the public sector , the policy aspects of private funding have been largely overlooked in the european countries , particularly in those wit...
introductionthe role of private funding in long - term care programmes ( ltc ) is increasing worldwide . as stated by the world health organisation ( who ) , funding is a major tool for policy and planning . although this is well accepted in the public sector , the policy aspects of private funding have been largel...
magnetic resonance imaging ( mri ) is one of today 's fastest growing imaging modalities , spurred in part by rapid advances in technology and important new applications in patient care . medical doctors can obtain highly refined images of the body 's interior without surgery , with the use of mri . by using strong m...
background : magnetic resonance imaging ( mri ) is one of today 's fastest growing imaging modalities , spurred in part by rapid advances in technology and important new applications in patient care . it was introduced in western jamaica in march 2005 at a non - hospital - based facility called north coast imaging mr...
this function is achieved and finely regulated by a number of cellular and molecular processes , including tubular reabsorption of water and sodium through renal water channels ( aquaporins ) and sodium transporters under the tight control of hormones and nerves along with intracellular signaling pathways . vasopress...
vasopressin , angiotensin ii ( angii ) , and aldosterone are essential hormones in the regulation of body fluid homeostatsis . we examined the effects of angii or aldosterone on the regulation of body water balance . we demonstrated that 1 ) short - term treatment with angii in the primary cultured inner medullary ...
encephalopsin , also called opn3 or panopsin ( halford et al . 2001 ) , belongs to one encephalopsin / tmt - opsin subfamily of the seven subfamilies of the opsins . opsins are known to mediate phototransduction in both visual and non - visual systems by being transmembrane proteins acting as g - protein - coupled re...
encephalopsin belongs to the family of extraretinal opsins having a putative role in cns tissue photosensitivity . encephalopsin mrna has earlier been localized in rodent brains , but expression and localization of the protein has not yet been reported . in this study , we aimed to define encephalopsin protein abunda...
intentional weight loss among overweight and obese adults ( body mass index 25 kg / m ) is associated with numerous health benefits . reviews of the literature suggest that diet - plus - physical activity weight loss interventions produce greater weight losses than diet - only interventions [ 1 , 2 ] . however , ...
intentional weight loss among overweight and obese adults ( body mass index 25 kg / m2 ) is associated with numerous health benefits , but weight loss maintenance ( wlm ) following participation in weight management programming has proven to be elusive . many individuals attempting to lose weight join formal progra...
janet g. travell first described myofascial pain syndrome ( mps ) in 1942 . the terminology used for mps was established in 1983 , and mps was accepted as a clinical diagnosis1 . myofascial pain syndrome is characterized by multiple trigger points in taut bands and facial constrictions . in clinical practice , ...
[ purpose ] the purpose of this study was to determine the short- and mid - term effects of kinesio taping on the trapezius muscle in individuals with myofascial pain syndrome . [ subjects and methods ] thirty - seven patients with active upper trapezius myofascial trigger points were randomly divided to 2 groups...
osteoprotegerin ( opg ) was first identified in 1997 simultaneously by two different research groups . ( 1997 ) were involved in a foetal rat intestine complementary deoxyribonucleic acid- ( cdna- ) sequencing project when they discovered a new possible member of the tumour necrosis factor ( tnf ) receptor superfam...
osteoprotegerin ( opg ) , a glycoprotein traditionally implicated in bone remodelling , has been recently related to cardiovascular disease ( cvd ) . human studies show a positive relationship between circulating opg , vascular damage , and cvd , and as such opg has emerged as a potential biomarker for cvd . this r...
a 41-year - old woman presented with intermittent pharyngeal obstruction and repeated vomiting after meals . concerning her previous history , she had undergone the resection of a fibroma in the right side of her neck 7 years earlier , and complained of a voice change over the past 3 months . the family history was not...
hemangiomas that arise in cervical esophagus are extremely rare , representing 3.3% of all benign esophageal tumors . although endoscopic mucosal resection ( emr ) and potassium titanyl phosphate / yttrium aluminum garnet ( ktp / yag ) laser therapy have been used with success for small tumors , the safety and effica...
adolescence is the transitional period between childhood and adulthood that is accompanied by refinement of cognitive functions thought to underlie the acquisition of mature behavior ( casey et al . , 2000 ; many of these executive functions , such as problem solving , working memory , abstract thinking , and increas...
the cannabinoid receptor 1 ( cb1r ) is the g - protein coupled receptor responsible for the majority of the endocannabinoid signaling in the human brain . it is widely distributed in the limbic system , basal ganglia , and cerebellum , which are areas responsible for cognition , memory , and motor control . because...
smoking is one of the most serious public health issues in the world . despite a recent downward trend respiratory morbidities are significantly higher in children who had a smoking parent than in those who had not ( 1 ) . in 1999 , premature death due to smoking was estimated at 57.7% in males and 11.4% in females i...
this study reports the stages of change in smoking cessation in a representative sample of korean adult smokers . the study subjects , all adult smokers ( n=2,422 ) , were recruited from the second korea national health and nutrition examination survey conducted in 2001 . the stages of change were categorized using...
although surgical resection remains the mainstay of gastric cancer treatment , it is associated with a high risk of complications reaching up to 46% , despite recent advancements in surgical technique and perioperative care . moreover , due to poor general status of patients with gastric neoplasms ( up to 40% of them...
backgroundsurgery remains the mainstay of gastric cancer treatment . it is , however , associated with a relatively high risk of perioperative complications . the use of laparoscopy and the enhanced recovery after surgery ( eras ) protocol allows clinicians to limit surgically induced trauma , thus improving recove...
materials azide - free antibodies ( abs)2 to 1 ( jb1a lm534 ) , 1 ( fb12 ) , 2 ( p1e6 ) , 4 ( p1h4 ) , 5 ( p1d6 ) , v ( p3g8 ) , and 6 ( nki - goh3 ) ; mab to 21 integrin ( mab1998 ) , ab against the 1 integrin cytoplasmic domain ( ab1934 ) , and mab to human chromogranin ( mab5268 ) ( chemicon ) , 2...
the human colorectal epithelium is maintained by multipotent stem cells that give rise to absorptive , mucous , and endocrine lineages . recent evidence suggests that human colorectal cancers are likewise maintained by a minority population of so - called cancer stem cells . we have previously established ...
erigeron multiradiatus ( lindl . ) benth is an important traditional tibetan medicine herbs used for thousands of years to treat various diseases , such as hypopepsia , enteronitis diarrhea , hepatitis , adenolymphitis rheumatism , and hemiparalysis . our previous researches on phytochemistry showed that e. multiradi...
scutellarein-7-o--d - glucuronide ( sg ) and apigenin-7-o--d - glucuronide ( ag ) are two major bioactive constituents with known pharmacological effects in erigeron multiradiatus . in this study , a simple method for preparative separation of the two flavone glucuronides was established with macroporous resins . t...
dna knotting is common in living cells and is easily observed in such systems like bacterial plasmids ( 1 ) , replication bubbles of bacterial chromosomes ( 2 ) or tightly packed dna in phage capsids ( 3 ) . dna topoisomerases enable passages of dna segments through each other and hence can knot and unknot circular d...
the action of various dna topoisomerases frequently results in characteristic changes in dna topology . important information for understanding mechanistic details of action of these topoisomerases can be provided by investigating the knot types resulting from topoisomerase action on circular dna forming a particular...
changes in modern pig reproduction have led to increased numbers of pigs born throughout a sow 's lifetime . there has been no monitoring of how the sows ' skeleton has reacted to these changes in irish conditions . furthermore , there is no information on how these changes in productivity have affected bone integr...
the objective of this study was to examine the differences in sow metacarpal properties through various parities and to compare the incidence of locomotory problems between stalled and loose - housed sows . metacarpals ( n = 110 ) of sows from six farms were collected at slaughter and stored at -20c . bones from on...
infantile hepatic hemangioendothelioma ( ihh ) is a vascular tumor of the liver composed of anastomosing vascular channels lined by plump endothelial cells . it is the most common vascular tumor of the liver in infancy and the third most common hepatic tumor in children . approximately 85% of affected patients pres...
abstractinfantile hepatic hemangioendothelioma ( ihh ) is the most common vascular tumor of the liver in infancy . adult with ihh is extremely rare . we presented a diffuse ihh in an adult patient with computed tomography ( ct ) and magnetic resonance image ( mri ) findings.a 39-year - old man was admitted to our h...
ocular dipping ( od ) , or inverse ocular bobbing , consists of slow , spontaneous downward eye movements with rapid return to the primary position . it has been mainly reported following hypoxic - ischemic encephalopathy , but has also been described in association with other types of diffuse or multifocal encephalo...
backgroundocular dipping ( od ) , or inverse ocular bobbing , consists of slow , spontaneous downward eye movements with rapid return to the primary position . it has been mainly reported following hypoxic - ischemic encephalopathy , but has also been described in association with other types of diffuse or multifocal...
kidney stones are a common disease worldwide and lead to a major comorbidity in industrialized countries . risk factors for kidney stones include age , gender , ethnicity , nutritional factors and genetic properties . previous studies have shown that hormonal factors play a role in the development of nephrolithiasi...
introductionprevious studies have shown that hormonal factors such as levels of insulin , cortisol , testosterone , and insulin resistance are related with increased nephrolithiasis ( nl ) . however , no previous study has evaluated the relationship between insulin , insulin resistance , thyroid hormones , cortisol ,...
several studies indicate that 1531% of the patients who undergo pkp may develop postoperative astigmatism greater than 5 diopters ( d ) [ 24 ] . graft refractive surgery ( grs ) consisting of relaxing incisions at steep meridians with or without counter - quadrant compression sutures can significantly reduce post - p...
purpose . to report outcomes of graft refractive surgery ( grs ) along with clear - cornea phacoemulsification and intraocular lens ( iol ) implantation in penetrating keratoplasty ( pkp ) eyes . methods . fourteen eyes of 13 patients who had received pkp underwent simultaneous grs ( relaxing incisions with or withou...
in many regions of the world , women have little or no authority or independence and are not in a position to demand safe sexual practices such as the use of barrier contraceptives . there is a great need , therefore , to identify methodologies that can be used discretely by women to prevent hiv transmission . an e...
abstracta lactobacillus - dominant vaginal microbiota has been shown to decrease heterosexual hiv transmission . nunn et al . now report that a vaginal microbiota dominated by lactobacillus crispatus is associated with a relative inability of hiv pseudoviral particles to transverse cervicovaginal mucus ( cvm ) in vit...
however , it increases in degrees to s h type iii in adolescents . in brief , relationships have been observed between age and the type of epiphyseal plate injury , with this type of injury changing with age . although there is report of cases that have distal phalanx fractures localized to the metaphyseal region ...
highlightswe encountered a patient with bony mallet finger without epiphyseal plate injurythe mechanism of this rare injury is discussed in this report.this injury may have occurred for two reasons . first , axial forces at the tip of the finger were small.second , intra - articular shearing forces from the head of t...
during the mammalian life cycle , two major epigenetic reprogramming events restore the developmental potential toward the totipotent and pluripotent states : in pgcs following their specification at embryonic days ( e ) 7.25e12.5 and during preimplantation development at e0.5e3.5 , respectively ( surani et al . , 200...
summaryprimordial germ cells ( pgcs ) and preimplantation embryos undergo epigenetic reprogramming , which includes comprehensive dna demethylation . we found that prmt5 , an arginine methyltransferase , translocates from the cytoplasm to the nucleus during this process . here we show that conditional loss of prmt5...
cutaneous melanoma ( cm ) is a severe type of skin malignancy and is responsible for the majority of skin cancer death . the incidence of this tumor is increasing worldwide especially in the fair - skinned populations . cm incidence has been steadily increasing since the mid 1960s and is predicted to continue incre...
abstractthe incidence of cutaneous melanoma is increasing worldwide , especially for thin melanoma ( breslow 1 mm ) . thin cutaneous melanoma has a favorable prognosis but there are few data about the prognosis of patients with ultra - thin cutaneous melanoma ( breslow 0.5 mm ) . our aim was to investigate the d...
ibandronic acid 1-hydroxy-3-[methyl(pentyl)amino]propane-1,1-diyl}bis(phosphonic acid ) is a nitrogen - containing bisphosphonate ( atc m05ba06 ; cas 114084 - 78 - 5 ) acting as an inhibitor of osteoclast - mediated bone resorption . ibandronic acid is effective for the treatment and prevention of osteoporosis in pos...
aimsthis bioequivalence study aimed to compare rate and extent of absorption of a generic medicinal product of ibandronic acid 150-mg film - coated tablet versus bonviva.methodsthis was a single - centre , open - label , randomized , three - way , three - sequence , reference - replicated , crossover bioequivalence stu...