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the inheritance of various traits or diseases from parent to offspring occurs primarily through dna .
when comparing two random human individuals , their dna is approximately 99.9 % identical .
the remaining 0.1 % of dna is responsible for their differences ( variations ) . the dna of an individual can change or ... | genetics plays an important role in the pathophysiology of cardiovascular diseases , and is increasingly being integrated into clinical practice . since 2008 , both capacity and cost - efficiency of mutation screening of dna have been increased magnificently due to the technological advancement obtained by next - gener... |
zinc oxide ( zno ) is a ii vi semiconductor material with a wide bandgap of about ( 3.37 ev ) together with a high exciton binding energy of ( 60 mev ) both at room temperature rendering zno to receive global attention especially in connection with the emerging nanotechnology paces toward functionality .
zno nanostr... | stable intrinsic white light
emitting diodes were fabricated from c - axially oriented zno nanorods ( nrs ) grown at 50c via the chemical bath deposition on top of a multi - layered poly(9,9-dioctylfluorene - co
n-(4-butylpheneylamine)diphenylamine)/poly(9,9dioctyl - fluorene ) deposited on pedot : pss on highly fl... |
arginine vasopressin ( avp ) is increasingly used in the management of refractory vasodilatory shock .
indeed , it was recently incorporated into the recommendations ( grade iib ) proposed by the american heart association for treatment of refractory septic shock and the guidelines of the surviving sepsis campaign ... | use of arginine vasopressin in the management of refractory vasodilatory shock has been associated with development of ischaemic skin lesions . because of the increasing popularity of arginine vasopressin , it is important to evaluate its effects on microcirculatory blood flow .
such studies are crucial if we are to ... |
acute liver failure ( alf ) , characterized by massive necrosis , is a syndrome defined by the onset of coagulopathy and hepatic encephalopathy and has a mortality rate ranging from 50% to 70% [ 16 ] .
the prognosis of this disease has not significantly improved , despite the introduction of supporting treatments suc... | this study aimed to investigate the role of 5-lipoxygenase ( 5-lo ) in acute liver failure ( alf ) and changes in macrophage activation by blocking it .
alf was induced in rats by administration of d - galactosamine ( d - galn)/lipopolysaccharide ( lps ) .
rats were injected intraperitoneally with aa-861 ( a specif... |
organic micropollutants such as pesticides
will only cause detrimental effects to organisms if they are taken
up by the organism and can reach a target site where they can do harm .
the processes of uptake , biotransformation , and elimination , also
termed bioaccumulation or toxicokinetics , modify the concent... | bioaccumulation and biotransformation are key toxicokinetic
processes
that modify toxicity of chemicals and sensitivity of organisms .
bioaccumulation
kinetics vary greatly among organisms and chemicals ; thus , we investigated
the influence of biotransformation kinetics on bioaccumulation in
a model aquati... |
as a service to our authors and readers , this journal provides supporting information supplied by the authors .
such materials are peer reviewed and may be reorganized for online delivery , but are not copyedited or typeset .
technical support issues arising from supporting information ( other than missing file... | abstractdirect sersbased quantification of inorganic metal species has been a problem , because they have a small raman crosssection or even no vibrational mode . here , we report a new strategy for sersbased quantification of such metal species , as exemplified by inorganic mercury ( hgii ) in waters .
stepbystep de... |
mouse behaviors vary across the light / dark cycle ( kopp , 2001 ; refinetti , 2006 ) . in mammals ,
ambient light is the best known factor that regulates circadian timing , primarily through neurons in the suprachiasmatic nuclei ( scn ) of the anterior hypothalamus ( menaker et al . , 1997 ; redlin and mrosovsky , 2... | mice are a nocturnal species , whose social behaviors occur primarily during the dark phase of the circadian cycle . however , laboratory rodents are frequently tested during their light phase , for practical reasons .
we investigated the question of whether light phase testing presents a methodological pitfall for i... |
photochemical
reactions induced by irradiation with ultraviolet
( uv ) light are utilized in a large variety of applications such as
surface cleaning , antiviral and bactericidal surface disinfection , air and water purification , photochemical surface modification , wettability alteration , material deposition ,... | we evaluated the sensitivity and
time resolution of a technique
for photochemical reaction monitoring based on the interferometric
detection of the deformation of liquid films .
the reaction products
change the local surface tension and induce marangoni flow in the
liquid film . as a model system , we consi... |
the brain is particularly susceptible to oxidative stress due to its high rate of oxygen consumption , its high proportion of polyunsaturated fatty acids and its low levels of antioxidant defense enzymes .
consequently , the brain is a first - class target in situations in which free radicals are implicated such as a... | aims .
3,5,4-trihydroxy - trans - stilbene , a natural polyphenolic compound present in wine and grapes and better known as resveratrol , has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism .
today , the mechanism by which ethanol exerts its toxici... |
atherosclerosis is an inflammatory disease which may be the outcome of responses to microbial antigens [ 1 , 2 ] .
several conserved components of the bacterial cell wall have been shown to bind to receptors on the cell surface of monocyte and macrophages which may induce production of proinflammatory cytokines .
... | plasma inflammatory markers have been shown to be predictors for cardiovascular risk , however , there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients ( cad pts ) positive for c. pneumoniae iga and high sensitive c - reactive protein ( hscrp ) which may... |
a total of 780 nondiabetic caucasian subjects , consecutively recruited in the university of rome and the university of catanzaro areas , participated in this cross - sectional study for assessment of cardiometabolic risk factors according to a previously described protocol ( 17,18 ) .
the inclusion criteria were age... | objectivewe evaluated whether cardiometabolic risk profiles differ for subjects identified as having prediabetes by a1c , fasting glucose ( fpg ) , or 2-h postchallenge glucose ( 2-pg ) criteria.research design and methodsatherosclerosis risk factors , oral glucose tolerance test , and ultrasound measurement of carotid... |
the reported prevalence of gestational diabetes mellitus ( gdm ) varies widely between 1 and 14% of all pregnancies ( 1 ) .
this wide variation may be explained in part by ethnic differences , and also by a lack of consensus in screening for gdm ( 3 , 4 ) .
universal screening for gdm , for example , is practiced b... | backgroundthe risk of gestational diabetes mellitus ( gdm ) in accordance to body mass index ( bmi ) is often based on studies where the calculation of bmi is frequently self - reported and is usually unreliable .
we evaluated the risk of an abnormal oral glucose tolerance test ( ogtt ) in a population where bmi was ... |
interventionalists have recently experienced success in closing these defects using devices designed to close atrial septal defects or a patent ductus .
several complications of this procedure , including embolization of the devices to the descending aorta , are well documented .
we report a case of embolisation of... | formation of an aneurysm in the sinus of valsalva of the aortic root is usually due to an area of congenital weakness in its wall .
this aneurysm may progressively dilate and rupture into any of the cardiac chambers or into the pericardial cavity . though this is conventionally treated by surgery
, interventional t... |
the population in korea is rapidly aging ; the proportion of people aged 65 yr and older increased from 7.2% in 2000 to 11% in 2010 ( 1 ) .
according to an official prediction based on the population dynamics of fertility and mortality , 14.5% of koreans will be over the age of 65 in 2018 , increasing to 20.8% by 202... | with the rapid aging of the population , korea introduced public long - term care insurance for older people in 2008 . the long - term care insurance was designed as a separate scheme from the national health insurance , with eligibility qualifications and the certification process based on functional disability , bene... |
most dorsal dislocation of the carpal scaphoid has been reported with axial dissociation of carpus or without other carpal injury.1234 complete dorsal dislocation of the carpal scaphoid associated with dorsal perilunate dislocation without axial dissociation of carpus is unique carpal injury which have not been reporte... | complete dorsal dislocation of the carpal scaphoid combined with dorsal perilunate dislocation is an extremely rare carpal injury .
we describe the case of a 23-year - old man who presented with a complete dorsal dislocation of the carpal scaphoid , combined with a perilunate dislocation .
surgical treatment was pe... |
acute kidney injury ( aki ) is a common condition among critically ill patients in the intensive care unit ( icu ) .
acute kidney injury results in rapid loss of kidney function and worsens the patient 's prognosis .
when severe , aki may necessitate the provision of renal replacement therapy ( rrt ) ; rrt can be a... | backgroundthe obective of this study was to perform a cost - effectiveness analysis comparing intermittent with continuous renal replacement therapy ( irrt versus crrt ) as initial therapy for acute kidney injury ( aki ) in the intensive care unit ( icu).methodsassuming some patients would potentially be eligible for e... |
a supernumerary tooth is a development anomaly of number characterized by the presence of tooth in addition to the normal series .
its prevalence rates of reported in the literature vary between 0.1% and 3.6% in the permanent dentition depending on the respective population .
supernumerary teeth can occur as single... | supernumerary teeth are extra teeth or toothlike structures which may have either erupted or unerupted in addition to the 20 deciduous teeth and the 32 permanent teeth .
mesiodens is one of these located in the midline between the two central incisors .
their presence may give rise to a variety of clinical problems... |
asthma affects up to 12% of adults and 25% of children in australia and there is a significant undiagnosed cohort .
although we have a range of medications that are effective in their own right , there is a need to further improve the management of this disease .
this involves better clinical programs and an improv... | little is known about innate immunity and components of inflammasomes in airway epithelium .
this study evaluated immunohistological evidence for nlrp3 inflammasomes in normal and inflamed murine ( balb / c ) airway epithelium in a model of ovalbumin ( ova ) induced allergic airway inflammation .
the airway epithel... |
the percentage of overweight and obese children and adolescents has increased and it is globally recognized as a serious health problem .
overweight and obese adolescents are at risk of getting chronic illnesses , and their mental health and self - esteem are affected as well . during adolescence ,
the frequency ... | background . the aim was to evaluate the effects of a 12-week , facebook - delivered lifestyle counselling intervention , with or without physical activity self - monitoring , on physical activity and body mass index ( bmi ) in overweight and obese 1316-year - old adolescents . methods . three - arm randomized controll... |
benign paroxysmal positional vertigo ( bppv ) is the most common vertiginous disorder in the community .
the cardinal symptom is sudden vertigo induced by a change in head position : turning over in bed , lying down in bed ( or at the dentist or hairdresser ) , looking up , stooping , or any sudden change in head pos... | bppv is the most common cause of vertigo .
it most often occurs spontaneously in the 50 to 70 year age group . in younger individuals
it is the commonest cause of vertigo following head injury .
there is a wide spectrum of severity from inconsistent positional vertigo to continuous vertigo provoked by any head mo... |
his best - corrected visual acuity ( bcva ) was 20/125 od and 20/20 os .
fundus examination od revealed prepapillary vascular loops with superotemporal macular branch vein occlusion ( appearing as the sheathed vessel ) and cystoid macular edema ( cme ) od [ fig . 1 ] .
the occlusion of branch retinal arteries was n... | a middle - aged diabetic and hypertensive man presented with diminished vision in the left eye .
fundus examination revealed prepapillary arterial loops , but with features of venous rather than arterial occlusion .
fluorescein angiography and optical coherence tomography confirmed the presence of a branch retinal ... |
management of multiple sclerosis ( ms ) and decision - making surrounding pregnancy are complex subjects which includes the risk of relapse during pregnancy and post - partum , the use of disease modifying therapies ( dmts ) before / during pregnancy and breastfeeding , and the impact of breastfeeding on the course o... | pregnancy in multiple sclerosis ( ms ) is considered safe for both the woman and the child . nevertheless , pregnancy issues in ms are complex both from a patient 's and a provider 's perspective . in an anonymous survey , 28 healthcare providers in the united states reported on the management of multiple sclerosis ( m... |
the aging process is typically characterized by a loss of muscular strength , reduction in joint mobility , reduction in cardiovascular capacity , and a decline in cognitive capacity.1 these physiological changes become more pronounced in postmenopausal women due to the development of osteoporosis and sarcopenia.24 the... | backgroundhealth - related fitness has been reported to be associated with improved quality of life ( qol ) in the elderly .
health - related fitness is comprised of several dimensions that could be enhanced by specific training regimens .
it has remained unclear how various dimensions of health - related fitness i... |
patients presenting to the emergency department ( ed ) with undifferentiated chest pain or other symptoms suggestive of acute coronary syndromes ( acs ) account for 10% of all ed visits and present a diagnostic challenge .
acs , an umbrella term used to denote the spectrum of myocardial ischemia , includes unstable a... | backgroundclinical symptoms are part of the risk stratification approaches used in the emergency department ( ed ) to evaluate patients with suspected acute coronary syndromes ( acs ) .
the objective of this study was to determine the sensitivity , specificity , and predictive value of 13 symptoms for a discharge dia... |
chrysanthemi flos ( cf ) , the flowers of chrysanthemum indicum or c. morifolium , is rich in volatile oils , flavonoids and so on .
macrophages are main players in the immune function as antigen - presenting cells in initiating adaptive immune responses and in the innate immune response .
many studies have demonst... | objectives : much evidence exists that herbs have effective immunomodulatory activities .
chrysanthemi flos ( cf ) is effective in clearing heat , reducing inflammation , dropping blood pressure and treating headache and is used as a pharmaceutical raw material for an immune enhancer .
the purpose of this study was... |
we have previously shown that c. elegans rab-11.1 , a homolog of human
rab11a , dynamically changes its localization and performs essential functions during the
oocyte - to - embryo transition . to
investigate the molecular mechanism by which rab-11.1 is activated , we searched for
rab-11.1 binding proteins usi... | abstractthe small gtpase rab proteins are key regulators of membrane trafficking .
rab11 is one of
the best - characterized molecules among the rab family proteins and it plays multiple roles
in endocytic recycling , exocytosis , and cytokinesis .
however , it remains unclear how rab11
is activated at a preci... |
asthma disproportionately burdens low - income african - american and hispanic children residing in inner cities such as the bronx , new york .
the bronx , which is predominately hispanic , is the new york city ( nyc ) borough with the highest overall rates of asthma hospitalizations , deaths , and prevalence among c... | parents often overreport adherence to asthma treatment regimens making accurate assessment of medication adherence in clinical practice difficult .
this study was conducted to compare two adherence assessment methods clinicians may choose from when assessing patient inhaled corticosteroid ( ics ) adherence : parental... |
stable and transient
phenoxyl radical species are important in
chemical processes spanning a large range of applications .
examples
include tyrosine / tyrosyl radical mediated enzymatic electron transfers
and hydrogen atom transfers , food preservation
( such as butylated hydroxytoluene or bht ) , and funda... | the
preparation and full characterization of the 4-(nitrophenyl)phenoxyl
radical , 2,6-di - tbutyl-4-(4-nitrophenyl )
phenoxyl radical ( tbu2nparo ) is described .
this is a rare example of an isolable
and crystallographically characterized phenoxyl radical and is the
only example in which the parent phenol... |
salmonellosis is a common foodborne disease caused by salmonella spp . and is of global significance .
it is a significant pathogen of food producing animals and remains a primary source of salmonellosis 1 .
salmonella spp . has been frequently reported in environmental samples since they find their way to the envi... | salmonella enterica subsp .
enterica serovar weltevereden is the most frequent serovar isolated from asia . here , we report a draft genome sequence of multidrug resistant salmonella weltevreden 9 isolated from seafood .
whole - genome of this isolate and annotation will help enhance the understanding of this patho... |
the classically described presentation is of insulin - dependent diabetes , followed by optic atrophy , central diabetes insipidus , and sensory neural deafness .
a 15-year - old boy with insulin - dependent diabetes was presented for evaluation of depressive symptoms associated with suicidal tendency .
neuropsychi... | background : wolfram syndrome is a rare hereditary or sporadic neurodegenerative disorder also known as didmoad .
the classically described presentation is of insulin - dependent diabetes , followed by optic atrophy , central diabetes insipidus , and sensory neural deafness .
also included are less well - described... |
glaucoma drainage implants ( gdi ) are a useful modality in the management of intractable glaucoma cases
. late exposure of the implant tube through the overlying conjunctiva is a known complication of the surgical procedure .
untreated tube exposure seems to be a risk factor for endophthalmitis.1 gedde et al . rec... | tube exposure is a known complication of ahmed glaucoma valve ( agv ) implantation .
repair of the exposed tube is not easy .
a 42-year - old monocular aphakic
male had undergone retinal detachment repair with placement of an episcleral - encircling band followed by implantation of agv .
he presented to the cli... |
the muenke syndrome ( ms ) is an autosomal dominant craniosynostosis syndrome associated with a mutation in the fibroblast growth factor receptor 3 ( fgfr3 ) gene located on chromosome 4p .
the mutation , involving the fgfr3 gene , consists of a heterozygous nucleotide transversion , c.749c > g , encoding the amino a... | the muenke syndrome ( ms ) is characterized by unicoronal or bicoronal craniosynostosis , midfacial hypoplasia , ocular hypertelorism , and a variety of minor abnormalities associated with a mutation in the fibroblast growth factor receptor 3 ( fgfr3 ) gene .
the birth prevalence is approximately one in 10,000 live b... |
tularemia has been a notifiable disease under the communicable diseases act in sweden since 1968 .
physicians who diagnose a case , either clinically or by microbiologic means , report to the county medical officer and the swedish institute for infectious disease control ( smi ) .
cases were defined as tularemia in... | a widespread outbreak of tularemia in sweden in 2000 was investigated in a case - control study in which 270 reported cases of tularemia were compared with 438 controls .
the outbreak affected parts of sweden where tularemia had hitherto been rare , and these emergent areas were compared with the disease - endemic ... |
the major components of chromatin are dna and histone proteins , although many other chromosomal proteins have prominent roles , too .
the functions of chromatin are to package dna into a smaller volume to fit in the cell , to strengthen the dna to allow mitosis and meiosis , and to serve as a mechanism to control ex... | chromatin remodeling and gene expression are regulated by histone deacetylases ( hdacs ) that condense the chromatin structure by deacetylating histones .
hdacs comprise a group of enzymes that are responsible for the regulation of both cellular and viral genes at the transcriptional level . in mammals ,
a total of... |
in this work , e. coli wm2949 ( 23 ) with plasmid pjat8-arae ( 24 ) was used except when stated otherwise . in this strain ,
the chromosomal arafgh and arae genes were deleted and arae expression is controlled by a constitutive promoter on the pjat8 plasmid , thereby allowing homogeneous expression from the pbad pro... | abstractprogrammed cell death ( pcd ) is an important hallmark of multicellular organisms .
cells self - destruct through a regulated series of events for the benefit of the organism as a whole .
the existence of pcd in bacteria has long been controversial due to the widely held belief that only multicellular organ... |
prepare a substrate for fruit fly eggs to be parasitized by preparing agar ( alternatively , gelcarin gp812 , fmc biopolymer , ewing nj ; a more cost effective option ) filled dishes , 10 cm in length per side and 1.5 cm depth .
fill dishes to the rim with liquid agar ( approximately 70ml ) , and allow them to cool a... | fopius arisanus ( sonan ) is an important parasitoid of tephritid fruit flies for at least two reasons .
first , it is the one of only three opiine parasitoids known to infect the host during the egg stage1 .
second , it has a wide range of potential fruit fly hosts . perhaps due to its life history
, f. arisanus... |
according to traditional chinese medicine ( tcm ) theory , certain points on the body are linked together in a network of channels called
tcm theory asserts that a smooth and adequate flow of qi defines health and suggests that the various characteristics of qi are determined by a complex set of interactions between ... | both hypnosis and acupuncture have gained credibility over the years in their effectiveness for treating various health conditions . currently , each of these treatments is administered in distinct settings and separate times .
that is , even if patients receive both treatments as part of a multidimensional therapeut... |
obstructive sleep apnea syndrome ( osas ) is characterized by episodes of obstruction ( partial or total ) of the upper airway during sleep secondary to a collapse of the structures of the upper airway during inspiration .
osas manifests itself as a reduction ( hypopnea ) or complete cessation ( apnea ) of airflow de... | introduction there are several studies on the pathophysiology and prevalence of obstructive sleep apnea syndrome ( osas ) , however , few studies address the epidemiological profile of these patients .
objective the aim of this study is to analyze the epidemiological profile of patients diagnosed with osas referred... |
temporary crown and fixed partial dentures are subjected to heavy and consistent loading by the mastication , and failure of the restoration frequently occurs .
one of the common failure modes of the restorations which may lead to severe economic loss and patient discomfort is fracture.1 the materials used for tempor... | purposethe purpose of this study was to investigate the diametral tensile strength of polymer - based temporary crown and fixed partial denture ( fpd ) materials , and the change of the diametral tensile strength with time.material and methodsone monomethacrylate - based temporary crown and fpd material ( trim ) and th... |
it has been proven that interferon -1a can reduce relapse rate , disease activity [ measured by magnetic resonance imaging ( mri ) scanning ] , and prevent disease progression [ 1 , 2 , 3 ] .
common side effects of interferon -1a include flu - like symptoms , headache , depression , insomnia , inflammation or cutaneo... | interferon -1a is a widely used immunomodulation treatment for multiple sclerosis .
liver function impairment is a common side effect and usually develops in the first 6 months after interferon use . here
, we describe 2 multiple sclerosis patients who developed delayed liver function impairment 5 years after recei... |
the rotator cuff disease is known as one of the most common causes of chronic shoulder pain in adults , and its treatment is considered important because of the increased geriatric population and the advances made in medical diagnosis and treatment since the rotator cuff tear repair was first reported by codman in 1911... | background : the goal of this study was to evaluate the outcome of the open repair of rotator cuff tears via the deltopectoral approach in patients unable to afford arthroscopic repair costs.methods:we evaluated 80 consecutive patients who were treated for full - thickness rotator cuff tears by open repair through the ... |
cannabis sativa l. has been widely utilized by humans for thousands of years for the relief of a wide range of physiological ailments . in the united states , there are currently 18 different states and the district of columbia that legally allow for the medical use of cannabis , and most recently the states of colorad... | the present study was conducted in order to quantify to what extent cannabis consumers may be exposed to pesticide and other chemical residues through inhaled mainstream cannabis smoke .
three different smoking devices were evaluated in order to provide a generalized data set representative of pesticide exposures pos... |
phylogeny is an ecologically meaningful way to classify plants and animals , as closely related taxa frequently have similar ecological characteristics , functional traits and effects on ecosystem processes . for bacteria ,
however , phylogeny has been argued to be an unreliable indicator of an organism 's ecology ow... | |
liver dysfunction in a patient with triple - negative ( estrogen , progesterone receptor - negative and her-2 neu negative ) breast cancer due to liver metastases represents a potentially serious situation , especially when the patient is anthracycline resistant .
breast cancer in the setting of liver of liver metast... | liver dysfunction in a patient with anthracycline - resistant breast cancer and liver metastases with poor performance status ( ps ) represents a serious situation .
taxanes are the drugs of choice , but once the transaminase enzyme levels are raised more than 10-times the upper limit of normal ( > 10 uln ) , paclita... |
the present generation usually recognizes irregular teeth or obvious jaw deformities and seeks treatment from an orthodontist , for improving teeth alignment , function , and facial esthetics . among these , once growth is ceased some patients neither growth modification nor the camouflage would be a possible solution ... | background : the aim was to evaluate the long - term hard and soft tissue changes following mandibular advancement and setback surgeries.materials and methods : a total of 16 subjects each were selected who underwent bilateral sagittal split osteotomy mandibular advancement and mandibular setback groups .
pre - surgi... |
the anterior approach to the cervical spine has been extensively used since its description in the late 1950s and is widely regarded as being safe and versatile with low rates of adverse events reported .
albeit very rare , esophageal perforation is a potentially fatal complication of anterior cervical spine surgery ... | study design : multicenter retrospective case series and review of the literature.objective:to determine the rate of esophageal perforations following anterior cervical spine surgery.methods:as part of an aospine series on rare complications , a retrospective cohort study was conducted among 21 high - volume surgical c... |
in order to isolate neuraminidase inhibitors , the fruiting bodies of p. igniarius were extracted using methanol for 2 days at room temperature .
the methanolic extract was concentrated under reduced pressure , and the resultant residue was partitioned twice with ethyl acetate .
the ethyl acetate - soluble layer wa... | during our ongoing investigation of neuraminidase inhibitors from medicinal fungi , we found that the fruiting bodies of phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant h3n2 influenza viruses .
two active compounds were isolated from the methanolic extract of p. ig... |
the current classification of periodontal diseases includes accidental , iatrogenic , and factitious traumatic lesions .
traumatic lesions , whether chemical , physical , or thermal induced , are seen very common in the oral cavity . although the prevalence of traumatic lesion on the gingiva is not known , it has bee... | injuries to oral soft tissue can be accidental , iatrogenic , and factitious trauma .
chemical , thermal , and physical agents are the main causative agents for oral soft - tissue burns .
the present case describes the chemical burn of oral mucosa caused by tetracycline hydrochloride and its management .
diagnosi... |
patients with heart failure symptoms due to severe left ventricular ( lv ) dysfunction and coronary heart disease face a poor prognosis with limited functional improvement and medical treatment only leading to limited survival .
some of the causes of heart failure are myocardial infarction and other forms of ischemic... | patients with heart failure symptoms due to ischemic cardiomyopathy face a poor prognosis without adequate treatment . in these patients with viable ischemic myocardium ,
revascularization surgery is not a new but an established treatment concept .
the cass study , published in 1983 , was already able to document ... |
cystic disease of the spleen is relatively rare , with an incidence of 0.07%.1 the splenic cysts categorized either as primary ( true cysts ) or as secondary ( pseudocysts ) .
the latter is mostly caused by abdominal trauma and has no epithelial lining in the cystic lumen .
additinoally , primary splenic cysts are ... | cystic disease of the spleen is a relatively rare disease .
it is classified either as a true primary cyst or as a secondary pseudocyst .
most splenic cysts are pseudocysts , which have non - epithelial lining , and are caused by previous abdominal blunt trauma .
conversely , primary splenic cysts have epithelial... |
strokes of the left middle cerebral artery ( lmca ) territory often lead to impairments in language function that are collectively referred to as aphasias .
language recovery after lmca stroke is highly variable , and many patients remain chronically aphasic despite optimal rehabilitative approaches [ 2 , 3 ] .
aph... | the effects of noninvasive neurostimulation on brain structure and function in chronic poststroke aphasia are poorly understood .
we investigated the effects of intermittent theta burst stimulation ( itbs ) applied to residual language - responsive cortex in chronic patients using functional and anatomical mri data a... |
in a case of acidosis induced by the administration of a mineral acid , such as hcl or nh4cl , acidemia itself increases serum k concentration .
it is well known that hyperkalemia is caused by the release of intracellular k into extracellular fluid .
in contrast , in animal experiments involving the administration ... | when acidemia occurs associated with mineral acids , there is a predictable increase in the serum k+ concentration . in uncomplicated cases of acidosis associated with nonmineral organic acids ,
the serum k+ concentration usually remains within the normal range .
the mechanism of this different effect of mineral an... |
the potential for osteochondral defects to self - repair is limited in part due to the hypocellular and avascular nature of articular cartilage .
osteochondral defects that fail to heal spontaneously may ultimately result in further joint destruction and osteoarthritis .
numerous surgical treatment modalities have ... | purposethe purpose of this study was to assess the effect(s ) of platelet - rich plasma ( prp ) on osteochondral donor site healing in a rabbit model.methodsosteochondral donor sites 3 mm in diameter and 5 mm in depth were created bilaterally on the femoral condyles of 12 new zealand white rabbits .
knees were random... |
during the fifth week of gestation , ectodermal thickening is differentiated to form milk - line or mammary ridges on the ventral side , which are extended bilaterally from the axilla to the groin . normally , these ridges persist in the pectoral region allowing for the development of breast tissue and regress in non -... | ectopic breast is defined as the presence of breast tissue outside the pectoral region . in this article
, we are reporting an extremely rare case of pulmonary aberrant breast tissue . a 79-years - old caucasian woman with the history of hypertension , diabetes mellitus and ischemic heart disease , presented to the e... |
this disorder is highly prevalent around the world , with an estimated 1015% of us adults suffering from tinnitus .
tinnitus is the number - one service related disability , with over 744,000 total veterans receiving disability compensation at a cost to american taxpayers over $ 2.26 billion in 2014 .
the underlyin... | tinnitus is the phantom perception of sound in the absence of an acoustic stimulus . to date , the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain .
the aim of the present study was to measure changes in oxy - hemoglobi... |
high - quality images are crucial to accurately diagnose a patient or determine treatment . in addition to requiring the best images possible
many imaging systems use x - rays to provide a view of what is beneath a patient 's skin .
x - ray radiation levels must be kept at a minimum to protect both patients and sta... | in this paper , we consider nonlinear partial differential equations ( pdes ) of diffusion / advection type underlying most problems in image analysis . as case study , we address the segmentation of medical structures . we perform a comparative study of numerical algorithms arising from using the semi - implicit and t... |
thalassemia major is a congenital defect of globulin chain synthesis , ineffective erythropoiesis and intense anemia .
the chronic anemia leads to growth retardation , bone marrow expansion , extramedullary hematopoiesis , splenomegaly , greater intestinal iron absorption , hypercoagulability and higher propensity to... | background : cardiac complications are the primary cause of death in patients with b thalassemia major .
qtc interval is an indicator of variability of ventricular repolarization and is supposed to be prominent in high risk patients .
the aim of this investigation was to evaluate the relationship between qtc interv... |
though well known , ruptured sinus of valsalva ( rsov ) aneurysms are rare comprising 0.3 - 3.56 % of all congenital heart diseases.1 they are thin walled outpouchings of the sinus of valsalva and may be tubular or saccular in shape .
the right sinus of valsalva is most commonly involved and usually ruptures into rig... | we report a rare case of sinus of valsalva aneurysm of left aortic sinus , which was bulging into left atrium ( la ) distorting mitral valve and rupture into the left ventricle with severe aortic regurgitation in a 25 years old male patient . due to the rupture
, both aortic and mitral valves were irreparable and req... |
the survey used a random sample of 508 surgery residents from 7 ( dandong , dalian , yingkou , chaoyang , tieling , fushun , and shenyang ) of the 14 cities that constitute the liaoning province , covering the geographic diversity of the east , south , west , and north areas of liaoning province .
the cross - section... | abstractthe objective of this study was to assess the competency of surgery residents from the patient perspective in the current healthcare environment in china .
the authors performed an assessment of 508 surgery residents in liaoning province .
seven patients were as a group to complete the self - administered q... |
adenoid cystic carcinoma ( acc ) of the breast is a rare condition , and cases in male patients are even less common .
we describe a case of acc of the breast with axillary lymph node metastasis , disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year - old man .
male breast acc is an extr... | introductionadenoid cystic carcinoma ( acc ) of the breast is a rare condition , and cases in male patients are even less common.casewe describe a case of acc of the breast with axillary lymph node metastasis , disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year - old man.conclusionmale bre... |
a 15-year - old iranian girl was admitted to tehran pediatrics medical center , tehran ( iran ) in june 2006 . on admission
also , she had submandibular soft - tissue asymmetry , night sweats , and proptosis ( figure 1 ) and round shape painless patches on the arm and leg extensor surfaces ( figure 2 ) . a 15-year - ... | rosai - dorfman disease ( rdd ) is a rare lymphoproliferative disorder with nodal and extranodal involvements .
here we report a case of rdd in a 15-year - old female who presented with epigastric pain , fatigue , raynaud phenomenon in fingers , submandibular lymphadenopathy , proptosis , hepatosplenomegaly , and rou... |
in 1987 , francine shapiro , a former english teacher , reportedly walked in a park , and noticed that unpleasant thoughts seemed to fade when she moved her eyes quickly back and forth ( luber , 2009 ; rosen , 1995 ) .
two years later , she launched a new treatment for post - traumatic stress disorder ( ptsd ) , whic... | there is increasing attention for embedding research in mental healthcare .
this involves a linkage between scientific research and routine practice , where research is fed by questions from practice and scientific insights are implemented better and faster in clinical practice .
this paper illustrates bridging the... |
malaria is among the leading causes of childhood mortality in guinea - bissau , comprising 18% of mortality of children less than five years of age as of 2010 (
who , 2010 ) .
however , the human malaria incidence rate in guinea bissau varies considerably from year to year with a general decrease in recent years to... | presence of
plasmodium
falciparum circumsporozoite protein ( csp ) was detected by enzyme linked immunosorbent assay ( elisa ) in a sample of
anopheles
gambiae s.s .
,
a. melas and
a. pharoensis collected in guinea - bissau during october and november 2009 .
the percentage of
p. falciparum infected sa... |
ampk , or 5'-adenosine monophosphate - activated protein kinase , is an evolutionarily conserved serine / threonine kinase that plays a crucial role in regulating energy homeostasis . in higher order eukaryotes , it is expressed in multiple systems and serves as an integrator of cellular and organismal energy balance a... | 5'-adenosine monophosphate - activated protein kinase ( ampk ) is an evolutionarily conserved cellular and organismal energy integrator that responds to numerous stimuli with the overall intention to facilitate energy conservation and enhance energy balance while also affecting cellular survival and behaviors .
ampk ... |
one of the best examples of how autocrine pdgf signaling contributes to malignancy is from studies of malignant gliomas .
co - expression of pdgf -receptor ( pdgfr ) and pdgf ligands are common in glioblastoma multiforme ( gbm ) , and frequently associated with p53 loss . enforced expression of pdgfr and pdgf - a con... | platelet - derived growth factors ( pdgfs ) and their receptors were identified and purified decades ago .
pdgfs are important during normal development and in human cancers . in particular , autocrine pdgf signaling has been implicated in various types of malignancies such as gliomas and leukemia . in contrast , par... |
anorectal malignancies are commonly adenocarcinoma or squamous cell carcinoma , with melanoma having a relative incidence of 0.54% of all malignancies in this region [ 1 , 2 ] .
this site is the third most common primary location for melanoma after skin and retina and yet only 0.41.6% of all primary melanomas arise h... | abstractanorectal melanoma is a rare disorder .
there have only been a few cases reported and there is no consensus of treatment .
we report a case of 50-year - old caucasian man presenting intermittent prolapse of an anorectal mass during 6 months with occasional bleeding .
biopsies came up with the diagnosis of... |
the participant of this study is a male subject ( 37 years old , 1.70 m , 67.40 kg and manual preference for right hand ) with complete sensory - motor thoracic traumatic spinal cord injury ( t9 ) , ais a ( american spinal injury association impairment scale ) and with 3 years post - sci .
he is a manual wheelchair u... | transfer is a key ability and allows greater interact with the environment and social participation .
conversely , paraplegics have great risk of pain and injury in the upper limbs due to joint overloads during activities of daily living , like transfer
. the main goal of this study is to verify if the use of funct... |
periodontitis is a multifactorial disease with microbial dental plaque as the initiator of periodontal disease.1 however , the manifestation and progression of periodontitis is influenced by a wide variety of determinants and factors including subject characteristics , social and behavioral factors , systemic factors ,... | objectivesthe aim of this study was to investigate the effect of cigarette smoking on clinical parameters and signs anemia of chronic disease in chronic periodontitis patients.methodsthe study base consisted of 88 patients with chronic periodontitis including 45 volunteer current smokers with age range of 3069 ( 45.58.... |
even though laryngotracheal strictures that are due to inhalation injuries frequently occur , the current treatment options for this medical condition are limited .
the management of laryngotracheal strictures that are caused by damage to the tracheal tissue from heat and intubation remains challenging .
the acute ... | the combined effects of inhaled irritant gases and heat in burn patients can result in the development of laryngotracheal strictures .
several factors could adversely affect the development of tracheal stenosis and cause the growth of granulation tissue . yet
the current treatment options for this condition are lim... |
age estimation is of great importance for the identification of victims of accidents and crimes . in case of living individual such as refugees and adopted children who have no acceptable identification documents , confirmation of chronological age
postmortem age estimation involves analyzing the remains of bones and... | context : age estimation using radiographs by kvaal and coauthors has shown to be reliable method , possible variation in ethnicity restricts its use in sample indian population.aims:thus this study was aimed at evaluating the accuracy of age estimation formula of kvaal and coauthors developed for norwegian population.... |
a model for the sequential generation of distinct cell types in the vertebrate cns . neural stem cells ( nscs ) from the rat embryonic brain give rise to progenitors that are restricted to neuronal or glial fates . in vitro treatment of glial - derived precursors ( grps ) with members of the bone morphogenetic protein ... | simultaneous suppression of glial scarring and a general enhancement of axonal outgrowth has now been accomplished in an adult rat model of spinal cord transection .
transplantation of a novel astrocyte cell type derived from glial - restricted precursors in vitro raise the eventual possibility of cellular therapy fo... |
considerable clinical evidence suggests that renin - angiotensin system ( ras ) inhibitors ( e.g. , ramipril and benazepril ) are beneficial as first - line agents for the treatment of hypertension in patients with chronic kidney disease ( ckd ) 1 - 4 .
however , by themselves , ras inhibitors are unable to maintain ... | objective : this study evaluated the non - inferiority of renoprotection afforded by benidipine versus hydrochlorothiazide in hypertensive patients with chronic kidney disease ( ckd).methods : in this prospective , multicenter , open - labeled , randomized trial , the antialbuminuric effects of benidipine and hydrochlo... |
a 53-year - old man presented with a 10-year history of a nodule that had recently started growing and producing an itching sensation on the right occiput .
a neck computed tomography scan suggested a benign soft tissue mass in the subcutaneous layer , so a local excision was performed .
the tumor measured 2.61.71.... | squamoid eccrine ductal carcinoma ( sedc ) is an exceedingly rare tumor that shows both squamous and adnexal ductal differentiation .
we report a case of this unusual tumor occurring on the occiput of a 53-year - old man .
a histopathological examination revealed a nodular lesion infiltrating the dermis and subcuta... |
the first land plant rooting structures comprised systems of tip - growing filamentous cells ( rhizoids ) . comparing the genetic mechanism that controls the development of filamentous rooting cells ( rhizoids and root hairs ) among different groups of land plants allows us to reconstruct the mechanism that controlled ... | summaryto discover mechanisms that controlled the growth of the rooting system in the earliest land plants , we identified genes that control the development of rhizoids in the liverwort marchantia polymorpha .
336,000 t - dna transformed lines were screened for mutants with defects in rhizoid growth , and a de novo... |
bacteremia or fungemia is associated with high mortality and can be diagnosed early with blood culture .
these are usually patients who are seriously ill with sepsis or children and adults with cardiovascular infections and paucibacillary disease .
appropriate antibiotic treatment is based on isolation , identifica... | aims : comparison of conventional blood culture with bactec 9050 for rate and time to detection of microorganisms.settings and design : a prospective study was carried out in a multispecialty tertiary care teaching hospital.subjects and methods : a total of 835 paired specimens ( 797 blood and 38 nonblood specimens ) w... |
osteosarcoma constitutes a small percentage of rare malignant non - epithelial neoplasms of the thyroid , and has been reported in only several dozen cases .
one of the conclusive tests is immunohistochemical staining , which excludes epithelial differentiation of the tumour .
we present a case of a female patient ... | a rare localization of primary osteosarcoma is presented .
a woman aged 76 years was operated on for rapid growth of thyroid right lobe tumour .
histopathology showed anaplastic cancer with numerous foci of osseous metaplasia , negative with thyroglobulin , calcitonin , synaptophysin and chromogranin .
a high pro... |
we enrolled 181 type 2 diabetic subjects using the following inclusion criteria : 1 ) ages > 35 and < 75 years , 2 ) serum creatinine levels less than 1.4 mg / dl and albumin excretion rate less than 300 mg / day , 3 ) hepatic enzymes levels less than three times upper normal , and 4 ) alcohol consumption less than 20 ... | objective adipocyte fatty acid binding protein ( a - fabp ) is a major cytoplasmic protein in adipocytes and macrophages and is closely associated with metabolic syndrome , type 2 diabetes , and atherosclerosis . here , we investigated whether a - fabp was associated with nonalcoholic fatty liver disease ( nafld ) in... |
gait refers to moving the body to targeted points using the legs as a complex and
integrated activity with low energy consumption involving alternative and harmonious
movements with normal tension of the antigravity muscles1 . during gait ,
the smaller the step length difference ( sld ) , stance
phase differenc... | [ purpose ] the purpose of this study was to examine the effects of pelvic adjustment
using gonstead techniques on posture in female university students . [ subjects ] in this
study ,
30 female university students were selected and divided into a pelvic adjustment
group of 15 subjects as an experimental group a... |
lupus nephritis ( ln ) is characterized by immune complex deposition and inflammation in glomeruli and the tubulointerstitium , but its precise pathogenesis is not very much clear until now .
many studies have indicated that systemic loss of b - cell tolerance results in the local deposition of immune complexes [ 1 ,... | aims . to assess the concentrations of serum cxcl13 and intrarenal ectopic lymphoid tissue ( elt ) profiles and their correlation in the patients with lupus nephritis ( ln ) .
methods .
serum cxcl13 levels were measured using enzyme - linked immunosorbent assays ( elisa ) .
the expression of cd3 , cd20 , and cd21... |
the prevalence of obesity in the united states has reached epidemic proportions and continues to rise .
numerous harmful sequelae of obesity including increased cardiometabolic risk and overall mortality have been demonstrated .
variations in body fat distribution , independent of generalized adiposity , may be ass... | backgroundupper body subcutaneous neck fat ( ubsf ) is a unique fat depot anatomically separate from visceral abdominal fat that appears to be associated with cardiometabolic risk above and beyond generalized adiposity .
we sought to develop a protocol to quantify ubsf using multidetector computed tomography measurem... |
transmembrane transport proteins often function in conjunction with auxiliary proteins that facilitate their vectorial activities [ 1 , 2 ] .
these proteins are the membrane fusion proteins ( mfps ; transporter classification number ( tc # ) 8.a.1 in the transporter classification database ( tcdb ; http://www.tcdb.or... | transport systems frequently include auxiliary proteins that perform subfunctions within the transporter protein complex .
two such proteins found in gram - negative bacteria are the membrane fusion proteins ( mfps ) and the outer membrane auxiliary ( oma ) proteins .
we here demonstrate that omas present in -prote... |
periodontitis is an immune - associated inflammatory disease of the periodontium characterized by progressive destruction of the supporting tissues of teeth .
it can destroy the surrounding connective tissue and adjacent alveolar bone and eventually causes tooth loss [ 2 , 3 ] .
the immune and inflammatory response... | periodontitis , a chronic infection by periodontopathic bacteria , induces uncontrolled inflammation , which leads to periodontal tissue destruction .
2,3,5,4-tetrahydroxystilbene-2-o - beta - glucoside ( thsg ) , a polyphenol extracted from polygoni multiflori , reportedly has anti - inflammatory properties . in thi... |
hyponatremia and an increased production of urine are frequently observed after calvarial remodeling in patients with craniosynostosis .
hypoosmotic conditions result due to sodium loss in the body when these symptoms are not corrected appropriately , leading to dysfunctional cerebral blood flow , circulation problem... | hyponatremia and increased urine output after calvarial remodeling have been noted in pediatric patients with craniosynostosis .
if not treated properly , patients develop hypoosmotic conditions that can lead to cerebral edema , increased intracranial pressure , and collapsed circulation .
postoperative hyponatremi... |
genetic nature of allergy and complex mechanisms governing the development of atopic phenotype already in fetal life have since long been recognized .
the process of hypersensitization begins synchronously with the initiation of fetal production of immunoglobulin e in the 11th gestational week .
the ige level in um... | the present study was conducted to learn whether the perinatal and environmental factors could influence the total and antigen - specific ige levels in umbilical cord blood .
retrospective data were obtained from 173 mother - infant pairs .
total and specific ( for children 's food , wheat / grass and house dust mi... |
hepatitis c virus ( hcv ) , a worldwide blood borne infection with a global importance , is a significant cause of hepatic diseases , cirrhosis and hepatocellular carcinoma , after hepatitis b which its screening was introduced in blood banking laboratory methods ( 1 - 5 ) .
chronic infection with hcv is a major caus... | background : hepatitis c virus ( hcv ) , a public health problem , is an enveloped , single - stranded rna virus and a member of the hepacivirus genus of the flaviviridae family .
liver cancer , cirrhosis , and end - stage liver are the outcomes of chronic infection with hcv .
hcv isolates show significant heteroge... |
all of the subjects who were consecutively observed in the outpatient unit of the pediatric department of pozzuoli hospital in the period between 2004 and 2010 were included in the study .
the majority of the children were referred by their general practitioners for allergy problems , overweight , and obesity , as de... | objectiveto evaluate whether the high triglyceride - to - hdl cholesterol ( tg - to - hdl - c ) ratio is associated with cardiometabolic risk ( cmr ) factors and preclinical signs of organ damage in an outpatient population of white children and adolescents.research design and methodsthe study population included 884 s... |
nineteen healthy men ( mean sem age 23.2 0.6 years and bmi 23.5 0.3 kg / m ) who were free of medication participated in the experiments .
they gave written informed consent to the study , which conformed to the declaration of helsinki and was approved by the local ethics committee .
each subject participated in... | objectiveanimal studies indicate a prominent role of brain insulin signaling in the regulation of peripheral energy metabolism .
we determined the effect of intranasal insulin , which directly targets the brain , on glucose metabolism and energy expenditure in humans.research design and methodsin a double - blind , p... |
people with intellectual disabilities comprise an estimated five million persons in the eu 27 member states .
evidence suggests that people in this group show negative disparities in health status and in access to optimal health care .
they are more likely to incur secondary health conditions and thus report increa... | introductionpeople with intellectual disabilities comprise an estimated five million persons in the eu 27 member states .
evidence suggests that people in this group show negative disparities in health status and in access to optimal health care .
they are more likely to incur secondary health conditions and thus r... |
a seizure is a transient disturbance of the cerebral function secondary to abnormal paroxysms in the brain , which results in a sudden excessive disorderly discharge of the cerebral neurons .
the discharge results in an almost instantaneous disturbance of sensation , loss of consciousness or psychic function , convul... | religious and sociocultural beliefs influence the nature of treatment and care received by people with epilepsy .
many communities in africa and other developing nations believe that epilepsy results from evil spirits , and thus , treatment should be through the use of herbaceous plants from traditional doctors and r... |
malignant liver tumors are considered to be one of the major public health problems in the world because of late diagnosis and failure of treatments .
there are mainly three kinds of malignant liver tumors in adults : hepatocellular carcinoma ( hcc ) , cholangiocarcinoma ( cca ) , and metastatic liver tumors .
appr... | backgrounddifferentiation of malignant from benign liver tumors remains a challenging problem . in recent years ,
mass spectrometry ( ms ) technique has emerged as a promising strategy to diagnose a wide range of malignant tumors .
the purpose of this study was to establish classification models to distinguish beni... |
economic evaluations are increasingly used to inform decisions regarding the allocation of scarce health care resources .
they generally take the form of cost - utility analysis , in which incremental costs per gained qaly ( quality - adjusted life year ) are evaluated against some threshold to ascertain the interven... | economic evaluations are increasingly used to inform decisions regarding the allocation of scarce health care resources . to systematically incorporate societal preferences into these evaluations ,
quality - adjusted life year gains could be weighted according to some equity principle , the most suitable of which is ... |
since , this gamma radiation is potentially harmful to the body , it is essential that minimum ( as low as reasonably achievable [ alara ] ) radiopharmaceutical dose be administered .
another important requirement for a diagnostic radioisotope imaging is that the patient remains static during data acquisition .
how... | purpose : acquisition of higher counts improves visual perception of positron emission tomography - computed tomography ( pet - ct ) image .
larger radiopharmaceutical doses ( implies more radiation dose ) are administered to acquire this count in a short time period .
however , diagnostic information does not incr... |
the kidney is an organ for metabolism and elimination of ths and a target of some of the iodothyronines actions .
thyroid dysfunction may effect on glomerular and tubular functions and electrolyte and water ( h2o ) homeostasis .
it may cause a reduction in glomerular filtration , hyponatremia , and h2o excretion al... | aims : the aim of this study focused on serum malondialdehyde ( mda ) levels and erythrocyte superoxide dismutase ( sod ) and catalase ( cat ) activities in hemodialysis patients and compared with control groups.materials and methods : forty - five hemodialyzed patients and 45 control groups recruited in this study .
... |
in contrast to the common finding of mucin production in non - endocrine epithelial tumors or mucinous metaplasia , in endocrine tumors it is an unexpected rare finding.1 mucin is rarely encountered in the primary thyroid neoplasm and only occasionally has mucin production been reported in medullary carcinoma or poorly... | we report two cases of follicular adenoma of the thyroid with extensive extracellular mucin deposition .
fine needle aspiration in case 1 showed singly discohesive polygonal cells in a granular mucinous background .
they contained abundant eosinophilic cytoplasm , nuclear irregularities , and frequent nuclear inclu... |
cleft palate is a frequent congenital defect , with an incidence of 1 per 700 to 1,000 live births .
the patients experience several problems in speech , feeding , dentition , maxillofacial growth , health status of the middle ear , and social relationships .
the paramount issues aimed at in the treatment of the cl... | background : current methods of closure of the cleft palate result in the formation of scars and impairment of growth .
distraction osteogenesis ( do ) might be an effective means to repair or at least reduce the size of wide clefts .
this study investigates the biomechanical aspects of this process.materials and m... |
world health organization estimated that 17.5 million of people die from cardiovascular diseases ( cvd ) each year constituting 31% of all deaths worldwide . among the cvd deaths ,
the evolution of treatment modalities and the intense public health preventive efforts has reduced the influence of smoking , untreated h... | objective . this study aimed to determine whether gender and ethnic differences had an effect on cardiovascular risk factors in overweight and obese rural adults in sarawak . design and setting .
this was a cross - sectional study conducted in rural communities in kuching and samarahan division , malaysia .
data wa... |
recently , there has been a shift in focus from individuals deficits to exploration of their strengths .
a study of the history of nursing shows that human strengths have been addressed in some nursing theories .
however , these theories are based on a deficit model rather than on improving the strengths and well -... | background : identifying and using the strengths of patients , in practice , is a new territory .
today , the need to educate nurses and psychiatric patients about positive psychology in practice and the importance of understanding and focusing on strengths is clear .
however , little is known about the strengths t... |
electron
paramagnetic resonance ( epr ) spectroscopy , when combined
with detailed computer modeling , is a powerful and valuable tool for
oligomeric protein complex structure determination and can be used
to probe structural details for these protein assemblies in the many
situations where x - ray crystallog... | we report here specialized functions
incorporated recently in the
rigid - body docking software toolkit tagdock to utilize electron paramagnetic
resonance derived ( epr - derived ) interresidue distance measurements
and spin - label accessibility data .
the tagdock package extensions
include a custom methan... |
one of the goals of the program is to support research projects that include one of the following objectives : identify health risks including those affecting vulnerable peoples , analyse the risks to health , and/or conduct a health risk assessment , and examine exposure and/or modelling data collection .
proposals ... | objectiveshealth canada 's program for climate change and health adaptation in northern first nation and inuit communities is unique among canadian federal programs in that it enables community - based participatory research by northern communities.study designthe program was designed to build capacity by funding commu... |
the online version of this article ( doi:10.1007/s00228 - 014 - 1660 - 7 ) contains supplementary material , which is available to authorized users .
given limited sample sizes , short duration , and lack of generalizability of preapproval clinical trials , a drug s safety profile at the time of regulatory approval i... | purposewell - designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation .
this study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis ( uc ) treated with mmx multi matri... |
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